Drugs Affecting Haematopoiesis
http://www.SalmonellaPlace.com This is a tutorial/lecture on the Drugs Affecting Haematopoiesis. We cover some topics important for classes such as Biochemistry and Pharmacology. If you have any questions, don #39;t be shy!! We hope we are able to clarify this topic. Enjoy! Plus, don #39;t forget to SUBSCRIBE for more! Facebook: http://www.facebook.com/salmonellaplace Twitter: http://www.twitter.com/thesalmonella Tumblr: http://www.salmonellaplace.tumblr.comFrom:TheSalmonellaPlaceViews:0 0ratingsTime:10:37More inEducation

See more here:
Drugs Affecting Haematopoiesis - Video

A University of Canterbury (UC) researcher will spend her summer months exploring the science behind brewing to meet the needs of the booming craft beer market.

UC summer scholarship student Jennifer Crowther said her research was an opportunity to explore the science behind brewing in an effort to improve the taste and quality of beer.

The taste of beer characteristics are influenced by a range of factors including the variety of hops and the types of yeast used. Research will be conducted into the biochemistry and genetics of yeast towards manipulating the flavour profile of beers.

This is a really exciting time to be studying beer with the rapidly growing craft beer market shifting emphasis towards brewing flavoursome, distinctive beers.

Crowther will be working alongside the Christchurch company Three Boys Brewery which has been operating out of Christchurch for more than eight years and is one of the premium microbreweries in New Zealand. Three Boys is run by former UC academic plant biochemist Dr Ralph Bungard.

The craft beer market is booming in New Zealand and in many traditional beer drinking countries around the world. Our overall beer consumption has been in decline for many years. In contrast, the craft beer sector, although small in terms of volume, has been rapidly increasing, both in terms of the number of breweries and the volume of beer produced.

This increase in popularity can be attributed to the more interesting flavours and styles of beer that the craft sector offers and the desire of consumers for choice and variation. The UC research project pulls together two of my favourite subjects in biochemistry and beer making.

The huge range of beer styles worldwide is a result of the almost endless combinations of many varieties of malt, hops and yeast strains. NZ has traditionally had an innovative hop and malt producing industry which has allowed craft brewers in NZ to produce beer with very unique, NZ-style flavours.

The biological modification of these malt and hop flavours and aroma in beer is driven by yeast in the fermentation. However, in the past, brewers have been less innovative in terms of the yeast use, sticking with traditional strains that have been used over many decades and even centuries of brewing.

The UC project will look more closely at the role of yeast in the biological modification of the flavour profile in beer. We want to particularly focus on how yeasts alter the end-product flavours that are derived from malt and hops.

Read more:
Researcher to explore science behind beer brewing

By Taylor Langston Posted on November 29, 2012 | News | No comment

This time of the the year for many club members represents tacky sweater parties and Christmas socials but Luke Sorrell, senior biochemistry major from Coppell, has a greater vision for the men of Galaxy.

This Saturday, members of the social club will be teaming up with Habitat for Humanity to help build a home for a deserving Abilene family.

For me specifically, community service and service is one of my passions and what I enjoy doing, Sorrell said. But I really want to see Galaxy more involved in the community.

That desire for community involvement is shared by Galaxy President Hutton Brown, senior English major from Midland.

Our motto is In all things let us keep God first, others second and ourself last and we wanted to implement Gods purpose however we can, Brown said. As college students, we may not have money we can spend but we do have time we can spend.

The day will be broken up into two different shifts, with one group working from 9:30 a.m-12:30 p.m, then handing off their progress to a second round of workers from 12:30-4:30 p.m.

Though this is the first year in recent years that Galaxy is partnering with Habitat for Humanity, Sorrell, along with many other Moonies, has high hopes for the tradition to endure.

I approached Keith Carroll about it after he started [as Social Service Director] about doing more service projects and he really wanted to get that started and implemented too. Sorrell said.

Although Sorrell believes that any form of service is beneficial, he said that there is a something special about working with the Habitat for Humanity organization.

More here:
Extreme makeover: Galaxy edition

Newswise The U.S. Department of Energy (DOE) has awarded Arizona State University (ASU) a grant for alternative energy research that is part of a special DOE program to pursue high-risk, high-reward advances with the potential to change the way the nation generates and consumes energy.

ASUs grant, led by Dan Buttry, professor and chair of ASUs Department of Chemistry and Biochemistry in the College of Liberal Arts and Sciences, is to develop an efficient and cost-effective carbon capture technology using an innovative electrochemical technique. ASU will separate carbon dioxide from other emissions coming from power plants with the real possibility of reducing energy and cost requirements by more than half. This could be an economically enabling breakthrough in the drive to reduce carbon dioxide emissions.

Through this type of venture we are working to advance research and spur economic development in the areas of renewable energy and energy security to create solutions that address societys grand challenges, said Sethuraman Panch Panchanathan, senior vice president for ASUs Office of Knowledge Enterprise Development. This innovative project is a collaborative effort of faculty at ASU from multiple disciplines who are developing a new carbon capture technology.

DOEs Advanced Research Projects Agency-Energy (ARPA-E) program has the goal of developing clever and creative approaches to transform the global energy landscape, while advancing Americas technology leadership. ASUs grant is for $612,000 for one year.

In announcing the awards, U.S. Energy Secretary Steven Chu said, With ARPA-E and all of the Department of Energys research and development efforts, we are determined to attract the best and brightest minds at our countrys top universities, labs and businesses to help solve the energy challenges of this generation. The 66 projects selected today represent the true mission of ARPA-E: swinging for the fences and trying to hit home runs to support development of the most innovative technologies and change whats possible for Americas energy future.

Inspired by the Defense Advanced Research Projects Agency, ARPA-E was created to support high-risk, high-reward research that can provide transformative new solutions for climate change and energy security. The projects were selected through a merit-based process from thousands of concept papers and hundreds of full applications. The projects are based in 24 states, with approximately 47 percent of the projects led by universities, 29 percent by small businesses, 15 percent by large businesses, 7.5 percent by national labs, and 1.5 percent by non-profits, according to the DOE in a release announcing the awards.

ASU has been building up its portfolio in alternative energy research for several years and currently includes, among its capabilities, a center for research into electrochemistry for renewable energy applications; several advanced programs on solar energy research; one of the leading testing and certification centers for solar energy; and research into solar-generated biofuels including advanced work on algae-based biofuels.

The potential this project has in advancing a viable solution to mitigating the significant carbon dioxide emissions into the environment is exciting and we look forward to the teams progress in this area, said Gary Dirks, director of ASU LightWorks. ASU is a place where the convergence of laboratory research and real-world application creates a unique environment where imaginative energy-related projects are fostered and encouraged.

The carbon capture program was initially supported by ASU LightWorks, which brings together the intellectual expertise across the university centered on leveraging the power of the sun to create solutions in the areas of renewable energy, including generating electricity, alternative fuels, and preparing future energy leaders.

We are extremely excited about this new grant from the Department of Energy ARPA-E program. The effort is focused on a key issue in fossil fuel-based energy production - how to reduce atmospheric carbon dioxide emissions without consuming too much of the energy content of the fuel, explained lead ASU researcher Dan Buttry. We have recently developed a new approach to carbon dioxide capture that uses an electrochemical process with some design features similar to those in a fuel cell.

View post:
Arizona State University Awarded DOE Grant to Advance Carbon Capture Technology

WELWYN GARDEN CITY, England and BOSTON, November 30, 2012 /PRNewswire/ --

Heptares Therapeutics, the leading GPCR drug discovery company, is delighted to announce that its Chief Scientific Officer and founder, Fiona Marshall, has received a 2012 Women of Outstanding Achievement Award from WISE, a UK national campaign to promote female talent in science, engineering, technology and the built environment. Dr Marshall received the award in the Innovation and Entrepreneurship category in recognition of her academic and industry achievements as well as her positive contributions in attracting women to the life sciences area.

Dr Marshall received her award from Her Royal Highness, The Princess Royal at the prestigious WISE Awards held yesterday at The Institution of Technology and Engineering in London, UK.

"I'm very grateful to receive this award. I have seen Heptares grow from just two of us in a portacabin to a world-leading biotech company with more than 60 scientists, including women from around the world, working in chemistry, crystallography, biochemistry and pharmacology. It has been wonderful to work with so many talented young scientists." commented Dr Marshall. "This team is central to Heptares' leadership in the GPCR field, solving the structures of clinically important GPCRs and leveraging this structural insight to discover and design exciting new drug candidates. Heptares today has a substantial pipeline of unique agents in development for treating serious diseases such as Alzheimer's disease, schizophrenia, chronic insomnia, addiction disorders, migraine and diabetes, as well as partnerships with multiple leading pharmaceutical companies."

Malcolm Weir, Heptares' CEO, added: "Fiona is an exceptional scientist and on behalf of all of us at Heptares, we congratulate her on receiving this award in recognition of her work; it is very well deserved."

Biography

Dr Marshall received a BSc in biochemistry from Bath University and a PhD in neuroscience from Cambridge University. She has more than 20 years' experience in drug discovery with particular expertise on GPCRs, is inventor of seven patents and author of over 60 peer-reviewed scientific papers in the area of GPCRs. Her work has contributed to the development of drugs for asthma, schizophrenia, heart disease and Parkinson's disease.

Dr Marshall set up Heptares Therapeutics, one of the UK's leading biotechnology companies, with Malcolm Weir in 2006. She now leads a team of 60 scientists at Heptares, which is pioneering a structure-based drug design approach to GPCRs and building a broad pipeline of novel medicines to transform the treatment of serious diseases. Heptares has established drug R&D collaborations with Shire, Takeda, AstraZeneca and Medimmune.

Before Heptares, Dr Marshall spent 12 years at GlaxoWellcome/GlaxoSmithKline where she held a number of senior positions including Head of the Department of Molecular Pharmacology and Head of GPCR research. She was Director of Discovery Pharmacology, Europe for Millennium Pharmaceuticals and then spent several years as an independent consultant to a variety of venture capital and biotech companies. She was chair of the BBSRC biochemistry and cell biology committee for three years and is currently Chair of the CRUK Drug Discovery Committee and Vice-chair of the Wellcome Trust Seeding Drug Discovery Committee.

A short video clip can be seen by clicking here.

See the article here:
Heptares Chief Scientific Officer and Founder Fiona Marshall Receives Prestigious UK "Women of Outstanding Achievement ...

(Phys.org)A Kansas State University research team has resolved a 40-year-old debate on the role of iron acquisition in bacterial invasion of animal tissues.

The collaborative researchled by Phillip Klebba, professor and head of the department of biochemistryclarifies how microorganisms colonize animal hosts and how scientists may block them from doing so. The findings suggest new approaches against bacterial disease and new strategies for antibiotic development.

The studyin collaboration with Tyrrell Conway, director of the Microarray and Bioinformatics Core Facilities at the University of Oklahoma, and Salete M. Newton, Kansas State University research professor of biochemistryrecently appeared in PLOS ONE. It shows how iron acquisition affects the ability of bacteria to colonize animals, which is the first stage of microbial disease.

"This paper establishes that iron uptake in the host is a crucial parameter in bacterial infection of animals," said Klebba, the senior author on the publication. "The paper explains why discrepancies exist about the role of iron, and it resolves them."

Iron plays a key role in metabolism, leading bacteria and animals to battle each other to obtain it. Klebba's team found that E. coli must acquire iron from the host to establish a foothold and colonize the guta concept that was often debated by scientists.

"For years it was theorized that iron is a focal point of bacterial pathogenesis and infectious disease because animals constantly defend the iron in their bodies," Klebba said. "Animal proteins bind iron and prevent microorganisms from obtaining it. This is called nutritional immunity, and it's a strategy of the host defense system to minimize bacterial growth. But successful pathogens overcome nutritional immunity and get the iron."

Little was known about what forms of iron enteric bacteriawhich are bacteria of the intestinesuse when growing in the host, but this study shows that the native Gram-negative bacterial iron uptake systems are highly effective. Scientists questioned whether prevention of iron uptake could block bacterial pathogenesis. This article leaves no doubt about the importance of iron when E. coli colonizes animals because bacteria that were systematically deprived of iron became 10,000-fold less able to grow in host tissues, Klebba said.

"This is the first time our experiments unambiguously verified the indispensability of iron in infection, because here we created the correct combination of mutations to study the problem," Klebba said.

Enteric bacteria have so many iron transport systems that it's difficult to eliminate them all. For example, E. coli has at least eight iron acquisition systems.

"These transporters are redundant because iron is essential," Klebba said. "Bacteria are resilient. If one system is blocked, then another one takes over."

See the rest here:
Battling bacteria: Research shows iron's importance in infection, suggests new therapies

DUBLIN--(BUSINESS WIRE)--

Research and Markets (http://www.researchandmarkets.com/research/xjlld8/the_biochemistry) has announced the addition of the "The Biochemistry of the Grape Berry" book to their offering.

Grapes (Vitis spp.) are economically significant fruit species. Many scientific advances have been achieved in understanding physiological, biochemical, and molecular aspects of grape berry maturation. Some of these advances have led to the improvement of wine quality through better grape growing practices; but this avenue of research is still wide open due to the complexity of the biochemical mechanisms involved in the development and ripening of grapes and their response to environment.

The Biochemistry of the Grape Berry is a pioneer offering for readers - giving a focused and integrated coverage of the key biochemical and molecular aspects of grape berry development and ripening. Readers will benefit from a comprehensive and updated coverage on key steps, mechanisms and regulation in grapevine biochemistry and molecular biology, provided by an international team of leading scientists. It provides useful references on this research area and original data from laboratories worldwide. The comprehensive range of topics covered in this e-book is valuable to a multidisciplinary readership including plant physiologists, enologists, microbiologists, wine makers, biochemists and students. Thus The Biochemistry of the Grape Berry represents a step forward in the comprehension of grape berry biochemistry, wine quality and health benefits.

Key Topics Covered:

1. Water Relations of the Grape Berry and Aquaporins

2. Mineral Compounds in the Grape Berry

3. Source/Sink Relationships and Molecular Biology of Sugar Accumulation in Grape Berries

4. The Biochemistry of Organic Acids in the Grape

5. Phenolics in Grape Berry and Key Antioxidants

See the article here:
Research and Markets: The Biochemistry of the Grape Berry