Lloyd Mayer, MD, Renowned Researcher and Leader of the Crohn’s & Colitis Foundation of America Passes Away

NEW YORK, NY--(Marketwired - September 06, 2013) - It is with great sadness that the Crohn's & Colitis Foundation of America (CCFA) announces the passing of immediate past Chairman of their National Scientific Advisory Committee (NSAC) Lloyd Mayer, MD. Dr. Mayer was also Professor and Co-Director of the Immunology Institute, the Dorothy and DavidMerksamer Professor of Medicine, and Professor of Microbiology at the Mount Sinai Medical Center.

"Lloyd was a visionary leader and a brilliant researcher who was involved with CCFA for almost 30 years," said Richard Geswell, President & CEO of the Crohn's & Colitis Foundation of America. "He was fundamental in helping us set our research agenda. His passion, leadership, scientific expertise, and commitment to improving the lives of patients, will be his legacy here at CCFA."

Dr.Mayer's research focused on mucosal immunoregulation, inflammatorybowel disease and cytokine regulation of human B-cell differentiation with special attention on the role of intestinal epithelial cells(IEC) in regulatory T-cell responses in the gut. He and his team were the first to show that the epithelial lining cells of the intestine are active regulators of mucosal immune responses that are distinct from those that regulate systemic immunity. These findings had a profound significance in the development of highly effective anti-inflammatory drugs for IBD.

Dr. Mayer had been a part of CCFA's research programs since the mid 1980s and he held several key leadership positions including Chair of the Research Training Awards Committee, Chair of the Grants Review Committee, a member of the Research Initiative Committee and most recently Chair of the National Scientific Advisory Committee. As Chair, Dr. Mayer revived CCFA's Clinical Research Alliance, was a force in the Microbiome initiative and laid the foundation for the CCFA Partners in Research Program (ccfapartners.org) which is a groundbreaking, online research database.

"Lloyd always said that he grew up scientifically with CCFA and he was particularly committed to sharing his expertise by training the next generation of young IBD investigators," said Marjorie Merrick, Vice President of Research & Scientific Programs. "He was a dedicated and awe-inspiring teacher, mentor and colleague to IBD researchers worldwide and a staunch friend to all he knew. He will be sorely missed."

Dr. Mayer graduated from the Icahn School of Medicine at Mount Sinai in 1976 and received the Mosby Award for Clinical Excellence at that time. From 1980 through 1984, Dr. Mayer held joint appointments at Rockefeller University and Mount Sinai.

He pursued his immunology interests in the laboratory of the late Dr. Henry Kunkel. In 1985, he became Associate Professor of Medicine and Microbiology at Mount Sinai. In 1986, he became the Director of the Division of Clinical Immunology. Shortlyafter achieving full Professorships in Medicine and Microbiology in1990, Dr. Mayer became Vice Chair of Medicine at the Mount Sinai Medical Center.He also received the Jeffrey Modell Foundation Lifetime Achievement Award.In1994, Dr. Mayer was named the David and Dorothy Merksamer Chair ofMedicine and in 1997 became Professor of Immunobiology and Chair of the Immunobiology Center at the Mount Sinai Medical Center.In 2007, he became Professor and Co-Director of the ImmunologyInstitute. He was also the Director of the Division of Gastroenterology(2003-2010).

Dr. Mayer received many awards for a life time of outstanding work including the Saul Horowitz Award and the Irma T.Hirschl Trust Career Development Award, the Jeffrey Modell Foundation Lifetime Achievement Award, the Jaffe Food Allergy Institute Award for Scientific Excellence, and the Crohn's & Colitis Foundation of America (CCFA) Scientific Achievement Award in Basic IBD Research. He spoke and published widely, and his research was consistently funded by the National Institutes of Health. He also leaves behind multiple generations of physicians who trained with and were mentored by him.

The Crohn's & Colitis Foundation of America staff and volunteers extend our deepest sympathy to the Mayer family. He is survived by his wife Dr. Jill Fishbane-Mayer and three children, Sara, Marisa and Josh.

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Lloyd Mayer, MD, Renowned Researcher and Leader of the Crohn's & Colitis Foundation of America Passes Away

Siemens recalls microbiology testing panels: FDA

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Siemens recalls microbiology testing panels: FDA

dna impact: Javed Akhtar offers help to UP wonder kid

Help has started to pour in for wonder kid Sushma Verma who has secured admission to M.Sc. (microbiology) at Lucknow University at the age of 13. She holds the record for being the youngest to complete High School (class X) in India at the age of seven.

dna had highlighted her plight and achievements in its edition on Thursday last. Her achievements deserve even more kudos as she has done it despite extreme deprivation.

Her father Tej Bahadur is a daily wage labourer and is barely able to run the household. Lucknow University (LU) procter Prof Manoj Dixit told dna that famous lyricist Javed Akhtar had come forward to help Sushma financially. He has sent a message through people he knows in Lucknow, he said.

Interestingly, neither Sushma nor her father have heard of Javed Akhtar. Neither do they know his son Farhan Akhtar or wife Shabana Azmi.

Besides, Rafat Sarosh, who works for Microsoft at Seattle, and Abhijit Patil, a microbiology teacher who runs a charitable foundation in Kolhapur (Maharashtra), have also offered to help Sushma. In his email to the Lucknow University, Rafat has mentioned that his father, an LU product, had gone through some very tough time, and total strangers came up and helped him. He said that if Sushmas fees is taken care of, he would be willing to give her Rs5,000 per month for other expenses. He has also offered to give her a laptop.

Prof Manoj Dixit said some LU teachers had also offered to help, and the LU authorities were also considering granting her fees waiver and hostel facility. We plan to collect about Rs5 lakh which should take care of her entire M.Sc. course, he said.

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dna impact: Javed Akhtar offers help to UP wonder kid

Research identifies how mouth cells resist Candida infection

Public release date: 2-Sep-2013 [ | E-mail | Share ]

Contact: Benjamin Thompson b.thompson@sgm.ac.uk 44-758-468-9611 Society for General Microbiology

Candida albicans is a common fungus found living in, and on, many parts of the human body. Usually this species causes no harm to humans unless it can breach the body's immune defences, where can lead to serious illness or death. It is known as an opportunistic pathogen that can colonise and infect individuals with a compromised immune system. New research, presented today at the Society for General Microbiology's Autumn Conference, gives us a greater understanding of how mucosal surfaces in the body respond to C. albicans to prevent damage being done during infection.

Researchers from King's College London focused on oral epithelial cells, a mucosal layer of cells that line the mouth, providing a barrier against microbes. The group challenged oral epithelial cells grown in vitro with C. albicans, looking at gene expression six and 24 hours after infection.

The results showed that a molecular signalling pathway know as the 'PI3 Kinase pathway' is activated as soon as five minutes after the epithelial cells encounter C. albicans, before the fungus has time to become invasive. This pathway seems to be involved in priming epithelial cells to protect against future damage. Inhibiting the PI3 Kinase pathway increased the amount of damage caused by C. albicans and reduced the normal tissue healing response.

This finding makes the PI3 Kinase pathway an attractive target for new therapeutics against C. albicans. Dr David Moyes, who presented the work at the conference, hopes that by boosting the activity of the pathway it may be possible to reduce the fungus's ability to cause tissue damage.

He explains, "We are developing a complete picture of how C. albicans interacts with the epithelial cells that make up our mucosal surfaces and learning how they are able to discriminate between harmless and harmful microbes.

"Many of the symptoms of C. albicans infection, are caused by the body's incorrect or overactive response to cell damage. Developing therapies that act on the patient, not the microbe, provides an entirely novel way of treating an infection and the likelihood of resistance is much reduced."

Candida infections are the third most commonly acquired hospital blood-borne infection, resulting in 50,000 deaths annually. Over 75 per cent of fertile age women will suffer from at least one Candida infection and there are around 2 million cases of oral candidiasis each year among HIV/AIDS patients.

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Research identifies how mouth cells resist Candida infection