Physiology 7/1/2014
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Physiology 7/1/2014 - Video
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Physiology 19/11/2014 – Video
Science prodigy Jessie MacAlpine, 18, takes on malaria with mustard oil
Bug enthusiasts who caught the January 2011 edition of the Journal of Insect Physiology may have noticed something odd on page 35, just under the lead scientists name:
Huron Park Secondary School, Woodstock, Ontario, Canada.
Jessie MacAlpine was only a Grade 9 student when she published her first research paper, The effects of CO2 and chronic cold exposure on fecundity of female Drosophila melanogaster.
Today, the 18-year-old is in her first year at the University of Toronto and has moved on to even loftier pursuits. Using a molecular compound she stumbled upon in high school, MacAlpine is developing a potential new drug for malaria, a parasitic disease that infects about 219 million people every year and is growing resistant to available drugs.
If all goes according to plan, MacAlpines drug will be cheap, effective and accessible to people in the developing world. It will also be made from mustard oil.
Globally, were always in desperate need of another anti-malarial product, said Ian Crandall, a U of T professor who has been working with MacAlpine at the Sandra A. Rotman Laboratories, where he is a principal investigator.
The interesting thing about what Jessie has been doing is (that) growing mustard oil is not something that requires a huge facility to do. If its kind of a natural product that can be used to treat malaria, then its something thats worth looking into.
The daughter of an accountant and stay-at-home mom, MacAlpine knew she wanted to be a scientist as early as Grade 2, when she signed one of her homework assignments Dr. Jessie MacAlpine. By the time she graduated high school, she had already won a top prize at an international science fair, launched a research collaboration with U of T scientists and made two interesting discoveries in her basement lab both of which she is now in the process of patenting.
One of her patents is for a bioherbicide, which MacAlpine developed using molecular compounds found in garlic mustard plants and Tim Hortons coffee grounds.
The other is a mustard-oil compound, allyl isothiocyanate the stuff that gives mustard and wasabi its pungent kick which she hopes to develop into a treatment.
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Science prodigy Jessie MacAlpine, 18, takes on malaria with mustard oil
Why we should consider obesity a disease
Welcome to Health Advisor, where contributors share their knowledge in fields ranging from fitness to psychology, pediatrics to aging. Follow us @Globe_Health.
Is Obesity a disease?
Last year, the American Medical Association officially acknowledged obesity as a disease. Not everyone agrees. There is no doubt that excess weight can cause a wide range of health problems, including heart disease and cancer not unlike smoking. But, while we may consider smoking an addiction, we would hardly consider it a disease. So why should obesity qualify?
There are at least three reasons why obesity is different.
The first is related to the complexity of energy balance. While simplistic notions of balancing calories in and calories out work well in physics, with obesity we are dealing with physiology (which I like to describe as biology messing with physics). Our bodies do a remarkable job of sensing changes in caloric intake or expenditure and show a wide variation in how they respond to such changes.
Overfeeding studies at the Mayo Clinic showed an almost four-fold difference in the amount of weight gained by healthy volunteers who were all fed an extra 1000 calories per day for eight weeks. Similarly, numerous studies have shown that individuals following exactly the same diet or exercise program will vary widely in their weight-loss response.
No amount of binge eating will turn Jack Sprat into a sumo wrestler. Meantime, his wife may well find herself stuck with her own excess weight, no matter how hard she tries to lose it.
Which brings me to the second point: Once established, obesity becomes a chronic problem. This has to do with the fact that our bodies will always defend the highest weight that we have achieved. We refer to this as the set-point. No matter how you got to 200 pounds, once there, it becomes the weight that your physiology will defend (and it will do so most effectively).
We not only have increasingly better insight into exactly how this set-point readjusts to ever-increasing body weight (through a process of inflammation and micro-scarring in the hypothalamus, the brain centre that regulates energy balance) but we also understand many of the hormonal and metabolic changes that occur as our bodies effectively defend their increasing fat mass.
Rather than viewing fat tissue as a simple storage depot for excess calories, we now look at body fat as a complex organ that interacts closely with other organs to maximize and sustain fat stores (perhaps in preparation for the next famine, even if it never comes).
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Why we should consider obesity a disease
Are enough women included in medical device studies, as required by the FDA?
PUBLIC RELEASE DATE:
23-Jan-2014
Contact: Vicki Cohn vcohn@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News
New Rochelle, NY, January 23, 2013-The U.S. Food and Drug Administration (FDA) mandates adequate enrollment of women in post-approval studies (PAS) of medical devices to ensure that any sex differences in device safety and effectiveness are not overlooked. A group of authors from the FDA report the results of a study evaluating the participation of women and analysis of sex differences in PAS in Journal of Women's Health, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The article is available free on the Journal of Women's Health website.
Women may respond differently to medical devices due to factors such as genetics, body size, hormones, or other intrinsic sex-specific or extrinsic societal or environmental factors. They may face greater or lesser risk of adverse events or derive more or less benefit. "Based on these findings, FDA implemented new procedures to ensure participation by sex is evaluated in PAS reviews," state the authors in their article "Enrollment and Monitoring of Women in Post-Approval Studies for Medical Devices Mandated by the Food and Drug Administration."
"It is critically important that we have adequate participation of women in clinical trials, and that we analyze sex differences in study outcomes and adverse events," says Editor-in-Chief Susan G. Kornstein, MD, Executive Director of the Virginia Commonwealth University Institute for Women's Health, Richmond, VA, and President of the Academy of Women's Health.
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About the Journal
Journal of Women's Health, published monthly, is a core multidisciplinary journal dedicated to the diseases and conditions that hold greater risk for or are more prevalent among women, as well as diseases that present differently in women. The Journal covers the latest advances and clinical applications of new diagnostic procedures and therapeutic protocols for the prevention and management of women's healthcare issues. Complete tables of content and a sample issue may be viewed on the Journal of Women's Health website. Journal of Women's Health is the Official Journal of the Academy of Women's Health and the Society for Women's Health Research.
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Are enough women included in medical device studies, as required by the FDA?
Synbiota Expands Into Antarctica, Attracts Investors
Montral (PRWEB) January 23, 2014
Today, with the addition of members in Antarctica, Synbiota Inc. connects synthetic biology researchers across all 7 continents, just 3 months after the company's launch. Also announced today is $300,000 in available funding for Synbiota members and their biological solutions.
"Genetic engineering is our best bet to save the world," says Bill Liao, Founder of CoderDojo, a global network of hackerspaces and partner at SOSVentures. "That's why we're offering Synbiota's global network of researchers and biohackers $300,000 in available funding to accelerate the development of sustainable biological solutions via the SynBio axlr8r program." Learn more, and sign up at synbiota.com/axlr8r.
Synbiota is satisfying a global need for advanced virtual lab technology with its free web-based software. Previously limited to large corporations such as Monsanto, genetic engineering is touted by experts as one of humanity's best tools to combat global challenges in climate, access to food, fuel, materials, and the development of effective, low-cost medicine.
"Biotech is advancing much faster than computer technology, and Synbiota is at the heart of this revolution" says Rob Carlson, principal at Biodesic, and synthetic biology advisor to corporations and governments around the world. "Bringing together a global cadre of independent researchers, and pairing them with real funding opportunities is just the sort of thing that ignites revolutions. This is an incredible opportunity for the iGEM, DIYBio, and entrepreneurial communities to fund their work."
About Synbiota:
Synbiota Inc. was founded in April 2013 with the mission to streamline life science R&D and to make it universally accessible. Synbiota was a Fellow of Mozilla Labs WebFWD, winner of Hacking Healths Most Transformative Technology award, recipient of grants from FedDev and the Eastern Ontario Development Program, and creator of the S PRIZE global biotech contest. Synbiota Inc. has offices at the Digital Media Zone at Ryerson University (DMZ) in Toronto, and Maison Notman in Montral.
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Synbiota Expands Into Antarctica, Attracts Investors
Looking for a ‘superhabitable’ world? Try Alpha Centauri B, says Astrobiology Journal
PUBLIC RELEASE DATE:
23-Jan-2014
Contact: Vicki Cohn vcohn@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News
New Rochelle, January 23, 2014The search for extraterrestrial life extends far beyond Earth's solar system, looking for planets or moons outside the "stellar habitable zone" that may have environments even more favorable to supporting life than here on Earth. These superhabitable worlds have unique characteristics and are ideal targets for extrasolar exploration, as described in a provocative Hypothesis Article in Astrobiology, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Astrobiology website.
In "Superhabitable Worlds" Ren Heller, McMaster University (Hamilton, Ontario, Canada) and John Armstrong, Weber State University (Ogden, UT), propose how tidal heating can create conditions in which life could emerge on an icy or terrestrial planet or moon once thought to be uninhabitable.
"A great place for hydrothermal microorganisms and a volcanic eruption in the weather forecast every morning and evening," says Norman Sleep, Senior Editor for Astrobiology and Professor in the School of Earth Sciences at Stanford University, "a tidally heated planet would be unpleasant though spectacular to visit."
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About the Journal
Astrobiology, led by Editor-in-Chief Sherry L. Cady, Chief Scientist at the Pacific Northwest National Laboratory, and a prominent international editorial board comprised of esteemed scientists in the field, is the authoritative resource for the most up-to-date information and perspectives on exciting new research findings and discoveries emanating from interplanetary exploration and terrestrial field and laboratory research programs. The Journal is published monthly online with Open Access options and in print, and is the Official Journal of the Astrobiology Society. Complete tables of content and a sample issue may be viewed on the Astrobiology website.
About the Publisher
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Looking for a 'superhabitable' world? Try Alpha Centauri B, says Astrobiology Journal
Alex Laskey intro_ How behavioral science can lower your energy bill – Video
Alex Laskey intro_ How behavioral science can lower your energy bill
By: Remko Cremers
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Alex Laskey intro_ How behavioral science can lower your energy bill - Video
Bioquark Inc. Appoints Dr. Joel I. Osorio MD, Specialist in Functional Anti-Aging Regenerative and Stem Cell Medicine …
Philadelphia, PA (PRWEB) January 23, 2014
Bioquark, Inc., (http://www.bioquark.com) a company focused on the development of combinatorial biologics for regeneration and disease reversion in human organs and tissues, today announces the appointment of Dr. Joel I. Osorio MD, as VP of International Clinical Development.
We are honored to have someone with Dr. Osorios experience join us as we execute on a globalized clinical strategy, said Ira S. Pastor, CEO, Bioquark Inc. His broad clinical experience in functional anti-aging regenerative and stem cell based medicine make him a very valuable addition to the Bioquark team.
Dr. Osorio brings over 9 years of experience in medical practice, both in the private practice and public medical settings. Currently the medical director of the medical spa Bamboo Rejuvenecimiento Facial y Coporal (http://www.bamboobelleza.com), Dr. Osorio has served in capacities in both private and public practice, as a hospital staff physician, and as emergency health services coordinator for a variety of private and public institutions throughout Mexico. He earned MD degrees at both Westhill University and the National Autonomous University of Mexico as a medical surgeon, has diplomas in aesthetic medicine from the Autonomous University of Guadalajara, is an Advance Fellow by the American Board of Anti-Aging and Regenerative Medicine (http://www.a4m.com/joel-osorio-bamboo-rejuvenecimiento-facial-y-corporal-naucalpan-estado-de-mxico.html), is a visiting scholar at University of North Carolina at Chapel Hill in dermatology, a fellow in stem cell medicine by the American Academy of Anti-Aging Medicine and University of South Florida, and currently is completing additional masters work in metabolic and nutrition sciences at University of South Florida. Dr. Osorio is also a member of the round table of ReGeNeRaTe Laboratories Mexico Committee (a DNAge-Lab Company), and has been actively working in the applied stem cell field since 2007. In 2011, Dr. Osorio became a member of the International Cellular Medicine Society, is a PRP certified practitioner in aesthetic and regenerative fields, and from 2009 to 2012 managed the blood bank at Ruben Lenero public hospital. Dr. Osorio frequently appears on Mexican national television programs and interviews regularly as a speaker on the topic of anti-aging (http://www.youtube.com/watch?v=Z4SvkBTS-P0) as well as contributes in various magazines and periodicals on anti-aging related subjects.
I am very excited about the candidates being developed at Bioquark and their very novel approach to human regeneration and disease reversion, as well as the broader biological programs focused on anti-aging," said Dr. Osorio. "I'm pleased to be joining the team and am looking forward to playing a more active role in this truly transformational platform."
About Bioquark, Inc. Bioquark Inc. (http://www.bioquark.com) is focused on the development of biologic based products that have the ability to alter the regulatory state of human tissues and organs, with the goal of curing a wide range of diseases, as well as effecting complex regeneration. Bioquark is developing biological pharmaceutical candidates, as well as products for the global consumer health and wellness market segments.
Nanomedicine and human upper limit – Video
Nanomedicine and human upper limit
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Nanomedicine and human upper limit - Video
Board of Ed. approves 7 new Chicago charter schools
BY BECKY SCHLIKERMAN Staff Reporter January 22, 2014 10:40AM
The Chicago Public Schools Board Meeting on Wednesday, January 22, 2014. | Chandler West/For Sun-Times Media
storyidforme: 60951976 tmspicid: 22087422 fileheaderid: 10465819
Updated: January 22, 2014 9:27PM
The Chicago Board of Education Wednesday approved proposals for seven new charter schools to open over the next two years, sparking some outcry from those wondering how the district could close dozens of neighborhood schools then open new charters.
This is a complex situation, Board of Education President David Vitale said. When we are making these decisions, it does affect neighborhoods. It does affect schools we understand that.
Our goal is for quality schools. Theres been an agnosticism towards the form of the schools, but there is a strong belief that charters do provide quality just like contract schools and just as importantly ... as our regular schools.
But Chicago Teachers Union President Karen Lewis called the boards approval of new charters hypocritical.
Freedom to choose is at the bedrock of our society, she said, but choice should be based on fact and data. What is being presented is a false choice. Knowledge is the basis for real choice. What parents and the public are being presented with is a pre-determined path that leads to the undermining of our neighborhood schools and the privatization of public education.
The proposals approved outright are:
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Board of Ed. approves 7 new Chicago charter schools
Physiology 9/1/2013 – Video
New Chair Appointed to Malignant Hyperthermia Advisory Council
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Newswise Robert T. Dirksen, PhD, Department of Pharmacology and Physiology at University of Rochester Medical Center has been newly appointed to Chair the Professional Advisory Council (PAC) of the Malignant Hyperthermia Association of the United States (MHAUS).
I am pleased to announce that Dr. Robert Dirksen, Professor in the Department of Pharmacology and Physiology at University of Rochester, has been appointed as Chair to the Professional Advisory Council (PAC) of the Malignant Hyperthermia Association of the United States (MHAUS), says MHAUS President Henry Rosenberg, MD.
Dr. Dirksen is an outstanding scientist who has focused much of his scientific efforts on understanding the underlying defects in skeletal muscle in patients with Malignant Hyperthermia, Myotonic Dystrophy and Central Core Disease among others. His particular focus has been on understanding the control Calcium movements in muscle and the relation of Calcium movements to abnormal muscle function. His work has been funded by the National Institutes of Health and the Muscular Dystrophy Association among others. He has published over 80 articles in leading scientific journals in addition to many abstracts, book chapters, and invited lectures.
As Chair of the Professional Advisory Council, Bob will work closely with the President, Executive Director, and Board of MHAUS to assess strengths/opportunities for the PAC; assign specific topics or documents requested for review to the PAC; synthesize PAC comments; keep the Board of Directors updated on research which has the potential to enhance MHAUS mission; advise on parameters for PAC membership and terms of service on the PAC; and be a member of the organizing committee for future scientific conferences.
About the Professional Advisory Council of MHAUS The Professional Advisory Council (PAC) of the Malignant Hyperthermia Association of the United States (MHAUS) are healthcare professionals from throughout the world who are expert in Malignant Hyperthermia and together approve and generate all content published by MHAUS.
What is Malignant Hyperthermia Malignant Hyperthermia (MH) is inherited genetic disorder found in an estimated 1 out of 2,000 people and triggered by certain anesthetics and/or the drug succinylcholine and most often experienced in individuals undergoing routine surgery but in rare cases MH can happen without anesthesia. The disorder is due to abnormally increased levels of cell calcium in the skeletal muscle. Symptoms include body temperature of up to 107 degrees, muscle rigidity, system-wide organ failure, and possible death.
There is mounting evidence that some patients will also develop MH with exercise and/or on exposure to hot environments. Without proper and prompt treatment with dantrolene sodium, mortality is extremely high.
About the Malignant Hyperthermia Association of the United States (MHAUS) MHAUS was founded families who lost their children to MH or could not find information about MH. In 1981 they found each other - and a doctor performing MH testing and agreed to make current information about MH available to all who need it!
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New Chair Appointed to Malignant Hyperthermia Advisory Council
Montgomery Blair produces 3 Intel finalists
Montgomery Blair High School in Silver Spring is boasting three finalists in the Intel Science Talent Search, the countrys oldest and most prestigious research contest for high school seniors.
The three Montgomery Blair students tapped by the Intel Foundation as finalists in this years competition are:
Shaun Datta, whose research project is Saturated Nuclear Matter in the Large Nc and Heavy Quark Limits of Quantum Chromodynamics
Neil Davey, with Early Cancer Diagnosis and Treatment through the Detection of Circulating Tumor Cells using Drop-based Microfluidics
Jessica Shi, with The Speeds of Families of Intersection Graphs
In addition, Benjamin Freed, a student at Governor Thomas Johnson High School in Frederick, also has been named a finalist. His project is Identification of Novel Regulatory Mechanisms of the K-Ras Oncoprotein.
There were no finalists from Virginia.
The Intel Science Talent Search, a program of Society for Science & the Public (SSP), chose 40 finalists from about 1,800 entrants across the country. They were judged on the originality of their research projects as well as their achievement inside and outside the classroom, according to contest organizers.
The finalists created projects that touched a variety of scientific disciplines, including behavioral science, biochemistry, bioengineering, chemistry, computer science, earth science, engineering, environmental science, materials science, mathematics, medicine, microbiology, physics and space science.
The 40 finalists will gather in Washington March 6 to 12 to compete for $630,000 in awards. They will undergo a judging process, meet prominent scientists and national leaders and show their work to the public at the National Geographic Society.
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Montgomery Blair produces 3 Intel finalists
Patient Uses Whitaker Wellness Supplements to Maintain Active and Healthy Lifestyle #WhitakerWorks – Video
Patient Uses Whitaker Wellness Supplements to Maintain Active and Healthy Lifestyle #WhitakerWorks
CALL (855) 869-3554 TO LEARN MORE ABOUT OUR PROGRAMS AT WHITAKER WELLNESS INSTITUTE http://www.WhitakerWellnessInstitute.com Conventional physicians are unreasonabl...
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Patient Uses Whitaker Wellness Supplements to Maintain Active and Healthy Lifestyle #WhitakerWorks - Video
Nanomedicine Market – Video
Nanomedicine Market
This kind of record consists of current market rates pertaining to nanomedicine current market for that predict period of time 2013 : 2019. The market dimens...
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Nanomedicine Market - Video
Pluristem Gains Most in 17 Months on Stem-Cell Study
Pluristem Therapeutics Inc. (PSTI), the Israeli developer of stem-cell therapies, rose the most in more than 17 months after an experimental treatment showed promise in a study of 20 patients with muscle injuries.
The stock surged 22 percent to 16.18 shekels ($4.63) at 11:04 a.m. in Tel Aviv. Earlier it gained as much as 27 percent, the biggest increase since Aug. 6, 2012. The shares fell 15 percent yesterday ahead of the study results.
The early-stage clinical trial assessing Pluristems placental-expanded, or PLX-PAD, cells in people who had a buttock muscle injured during hip-replacement surgery found the treatment was safe, the company said in a statement today. Patients getting the injection also fared better in a muscle-contraction exercise six months later.
These are remarkable results that signal advances in the cell-therapy industry, Jason Kolbert, an analyst with Maxim Group LLC in New York, said at a press conference organized by Pluristem in Tel Aviv.
The study results suggest the stem-cell therapy could help treat a broader range of muscle and tendon injuries, according to the Haifa-based company. We intend to move forward with implementing our strategy towards using PLX cells in orthopedic indications and muscle trauma, Chief Executive Officer Zami Aberman said in the statement.
The results come after the U.S. Food and Drug Administration in June placed one of Pluristems most advanced studies on hold after a patient suffered an allergic reaction. The hold was lifted in September.
To contact the reporter on this story: David Wainer in Tel Aviv at dwainer3@bloomberg.net
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Pluristem Gains Most in 17 Months on Stem-Cell Study
Genetic Engineering Project – Video
Genetic Engineering Project
Science Project.
By: Jackie Tiongco
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Genetic Engineering Project - Video
HealthForumOnline CE Course Author Flo Gelo, D.Min, NCPsyA Nominated for Scattergood Behavioral Health Foundation …
Philadelphia, PA (PRWEB) January 22, 2014
Flo Gelo, D.Min, NCPsyA, Associate Professor in the Department of Family, Community and Preventive Medicine and the Behavioral Science Coordinator for the Family Medicine Residency Program at Drexel University College of Medicine, as well as the Director, of the Humanities Scholars Program, has recently been nominated for a Scattergood Behavioral Health Foundation Innovation Award for distribution of her emotional and evocative short film, Emmas Haircut. This film is an intimate and bittersweet glimpse into the life of Emma Mon, a 32 year old wife and mother of two young children, who, when newly diagnosed with breast cancer, is faced with her own mortality and uncertainties about how to explain her illness to her young children. As Emma asks in the film, When a mothers most basic instinct is to protect her children, how does she go about telling them she has cancer? With the support of her husband Tom, Emma orchestrates an innovative and proactive way to safeguard the mental and emotional health of their young children and ultimately, promote coping for the family. Dr. Gelos film compassionately and thoughtfully illustrates how breast cancer impacts not only an individual, but also the whole family.
According to Kelly Harris, Director of the Cancer Support Community of Greater Philadelphia who nominated the project for this award, Emmas Haircut addresses difficult issues in a sensitive, informative way. We know first-hand how important it is to have support, information and education while going through a cancer diagnosis and subsequent treatment. This film, coupled with a discussion group, will be an invaluable resource for families in the most difficult of situations." By sharing the struggles of Emma and her family, Dr. Gelo hopes to raise awareness of the importance of emotional, as well as physical, health in caring for young mothers and families facing cancer.
Interested individuals can to http://www.scattergoodfoundation.org/innovideas/cancer-support-community-greater-philadelphia# to view Emmas Haircut and leave a comment. Comments are being accepted until February 1, 2014, to inform the judges of the award. If chosen, the Scattergood Behavioral Health Foundation Innovation Award will fund the creation and distribution of an educational and resource guide to supplement the film enhancing support for thousands of families coping with cancer.
The body of Dr. Gelos work focuses on helping those with chronic and terminal illness, particularly on cultural and religious diversity and medical decision-making at the end of life. As a former hospital and hospice chaplain, Dr. Gelo brings over twenty-five years experience working with patients receiving palliative care to her roles as pastoral psychotherapist in private practice and as Clinical Interventionist at Fox Chase Cancer Center. In her ongoing efforts to disseminate information to mental health providers, Dr. Gelo authored Integrating Spirituality into the Care of Medically Ill Patients: The Ethical Role of the Mental Health Professional a continuing education course available at HealthForumOnline, a nationally-approved provider of online CE courses for psychologists, social workers, counselors, and other allied health professionals.
HealthForumOnlines resource library incorporates continuing education courses that reflect a sensitivity to patient and caregiver demands. In addition to Dr. Gelos CE course, HealthForumOnlines extensive online CE library includes courses such as Anticipatory Mourning in Alzheimers Family Caregivers, Bereavement: A Comprehensive Guide for Health Professionals, Cancer in the Couple: Clinical and Ethical Considerations within the Dyad, Facilitating Adjustment in Families with a Chronically-Ill Child, and Self Care for Professional Alzheimers Caregivers. HealthForumOnline provides health professionals with nationally-approved online CE courses that are easily accessible and cost-effective, enabling them to assist patients and their caregivers in coping with illness.
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How to prescribe Anti-Aging medicine – Video
How to prescribe Anti-Aging medicine
How to prescribe Anti-Aging medicine Ronald Rothenberg, MD Watch the full presentation at http://www.fleetwoodonsite.com/a4m Recorded at the A4M December 201...
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How to prescribe Anti-Aging medicine - Video