Othropedic Surgeon Dr. Propper Speaks about Stem Cell Therapy - PRP - BMAC
Orthopedic Surgeon Dr. Propper Speaks about the Difference of Stem Cell Injection Therapy PRP - BMAC.

By: Dennis Spoonhour, DC

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Othropedic Surgeon Dr. Propper Speaks about Stem Cell Therapy - PRP - BMAC - Video

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Johns Hopkins researchers have discovered an unexpected phenomenon in the organs that produce sperm in fruit flies: When a certain kind of stem cell is killed off experimentally, another group of non-stem cells can come out of retirement to replace them.

The discovery sheds light on the tiny "environments" that stem cells occupy in animal bodies and may help explain how stem cells in tumors replenish themselves, the researchers report in the May 8 issue of the journal Cell Reports. Damage of the kind duplicated in the laboratory occurs naturally after exposure to radiation and perhaps also after ingestion of toxic chemicals such as those used in chemotherapy.

The research group, led by Erika Matunis, Ph.D., a professor of cell biology at the Johns Hopkins University School of Medicine, has been using the fruit fly as a model living system in which to study stem cells in their natural state. Most stem cell research is done on cells grown in the laboratory, but in real life, stem cells reside in tissues, where they are sequestered in tiny spaces known as niches. Adult stem cells keep dividing throughout life to make various kinds of cells, like new blood cells and germ cells.

Matunis's group studies such niches in fruit fly testes, the sperm-producing organs shaped like a coiled tube whose end houses a niche. In the niche are three kinds of cells: germ line stem cells, which divide to produce sperm; somatic cyst stem cells, which make a kind of cell that helps the sperm-producing cells out; and hub cells, which make signals that keep the other two kinds of cells going.

The hub cells are not stem cells; they have settled on their final form, incapable of dividing further or changing their functionor so everyone thought.

However, in a bid to figure out what happens when the somatic cyst stem cells are killed off, Matunis suggested that graduate student Phylis Hti figure out how to best do away with them, thinking the task would be straightforward.

Instead, she says, "it took a lot of heroic, patient combinations" of different genes working together to kill the somatic cyst cells, Matunis says.

"When we finally figured out a way to kill all of the somatic stem cells, we thought that the rest of the tissue would probably just empty out," she says. In 35 percent of testes, that's just what happened. But in the rest, the somatic stem cells grew back.

This was a surprise, Matunis says, and left a puzzle: Where were the new somatic stem cells coming from?

Read this article:
Surprise: Lost stem cells naturally replaced by non-stem cells, fly research suggests

St. Petersburg, FL (PRWEB) April 17, 2014

One of the most respected plastic surgeons in America is encouraging the FDA to move forward on approval of stem-cell based therapies inspired in part by Matthew McConaughey's recent Oscar win for the film Dallas Buyers Club. In the film, McConaughey portrayed Ron Woodroof, who fought the Food and Drug Administration over his use and distribution of unapproved but effective HIV/AIDS medications. In a letter to FDA comissioner Margaret A. Hamburg dated April 14th, Dr. Christian Drehsen of St. Petersburg claims that the story echoes current FDA treatment of stem cell therapies, of which almost none are approved for use in the United States.

Drehsen cites his extensive past experience working with stem cells, and calls on the FDA to provide more rapid approval for the procedures, which he says are safe and effective.

In the period 2009-2010, before the current regulatory embargo, Drehsen performed over 20 reconstructive and cosmetic stem-cell procedures using technology from the pioneering stem cell therapy research firm Cytori. In his letter, Drehsen writes that the results of his procedures were excellent, and hes frustrated with the limitations now in place.

Japan has approved these procedures. Much of Europe has approved them. Theyre changing peoples lives every day but not in the United States, the letter reads in part.

Stem cell therapies have myriad potential uses. Drehsen says that in his own practice at the Clinique of Plastic Surgery, their promise includes greatly improved outcomes for burn victims, patients with extensive sun exposure damage, and post-operative breast reconstruction procedures. Those therapies have been pioneered with good results in Europe and Australia, respectively.

Other treatments currently proven or under trial include treatments for traumatic hamstring injury (http://ir.cytori.com/investor-relations/News/news-details/2014/Cytori-to-Initiate-US-Clinical-Trial-of-Adipose-Derived-Regenerative-Cells-in-Hamstring-Injuries/default.aspx) and chronic heart failure (http://www.cytori.com/Innovations/ClinicalTrials/CardiovascularDisease.aspx).

Though much American resistance to stem cell research has been rooted in ethical concerns about the use of embryonic stem cells, the Cytori procedure uses Adipose-Derived Regenerative Cells, or ADRCs stem cells derived from the patients own body fat and altered for re-injection using a proprietary process. Dr. Drehsen was one of a handful of doctors in the United States to use this technology for plastic surgery before the FDA blocked its usage. This makes him one of the most experienced surgeons in the U.S. in non-embryonic stem-cell enhanced facelift procedures. Drehsens website (http://cliniqueps.com) features many examples of his past successful stem-cell procedure outcomes.

The FDA serves the vital function of ensuring patient safety. But these procedures have been proven safe," Drehsen concludes. "It should be no surprise that using a patients own tissue presents fewer risks than many alternatives. Its sad that these options have continued to be blocked by bureaucracy.

Drehsen says that much of the equipment used in his stem cell procedures now sits in storage, unused.

Continue reading here:
St. Petersburg Surgeon Dr. Christian Drehsen Lobbies FDA to Speed Approval of Non-Embryonic Stem Cell Therapy