Author Archives: ev1

Fifa 14 UT | Best Trading Methods – So Many Deals Hunter Chemistry Style Trading – Video

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Fifa 14 UT | Best Trading Methods - So Many Deals Hunter Chemistry Style Trading
The best trading methods on fifa ultimate team, how to make coins! Subscribe for daily videos. Facebook: https://www.facebook.com/iHazCarrot Twitter: https://twitter.com/iHazCarrot Twitch...

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Fifa 14 UT | Best Trading Methods - So Many Deals Hunter Chemistry Style Trading - Video

2014 UW – Madison, Masters in Biotechnology Graduation – CONGRATS! – Video

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2014 UW - Madison, Masters in Biotechnology Graduation - CONGRATS!
2014 UW - Madison, Masters in Biotechnology Graduation Dr. David Piper gives four main points of advice for 2014 Masters of Biotechnology Grads. Kurt Zimmerman congratulates each grad at the...

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2014 UW - Madison, Masters in Biotechnology Graduation - CONGRATS! - Video

PromaxBDA Local Awards Finalists – Target 12 Anatomy of an Investigation – Video

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PromaxBDA Local Awards Finalists - Target 12 Anatomy of an Investigation
2014 PromaxBDA Local Awards Finalist for Best General Branding/Image: News Station Image Target 12 Anatomy of an Investigation, WPRI Interested in attending Station Summit 2014? PromaxBDA...

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PromaxBDA Local Awards Finalists - Target 12 Anatomy of an Investigation - Video

Quantity, not quality: Risk of sudden cardiac death tied to protein overproduction

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PUBLIC RELEASE DATE:

27-May-2014

Contact: Shawna Williams shawna@jhmi.edu 410-955-8236 Johns Hopkins Medicine

A genetic variant linked to sudden cardiac death leads to protein overproduction in heart cells, Johns Hopkins scientists report. Unlike many known disease-linked variants, this one lies not in a gene but in so-called noncoding DNA, a growing focus of disease research. The discovery, reported in the June 5 issue of The American Journal of Human Genetics, also adds to scientific understanding of the causes of sudden cardiac death and of possible ways to prevent it, the researchers say.

"Traditionally, geneticists have studied gene variants that cause disease by producing an abnormal protein," says Aravinda Chakravarti, Ph.D., a professor of medicine, pediatrics, molecular biology and genetics, and biostatistics in the McKusick-Nathans Institute of Genetic Medicine at the Johns Hopkins University School of Medicine. "We think there will turn out to be many DNA variants that, like this one, cause disease by making too much or too little of a normal protein."

Chakravarti's interest in sudden cardiac death emerged a decade ago, when it claimed several of his colleagues within a few months. An expert in complex common diseases, he and his team knew that sudden cardiac death can be caused by many conditions. They focused on one: abnormalities in what is known as cardiac repolarization the time it takes for the heart to gear up to beat again.

The team compared the genetic sequences of tens of thousands of people with their electrocardiogram (ECG) results, identifying several regions on the genome with genetic variations associated with lengthened QT interval, a measure of cardiac repolarization, in the ECG. "The problem is that most of these variants lie outside of genes, in the noncoding DNA that controls how genes are used," Chakravarti says, "so it's hard to tell what genes they're affecting."

Despite the challenge, Chakravarti and his colleagues were able to home in on one suspect region of the genome housing a gene called NOS1AP. "There were many variants grouped in this area," says Ashish Kapoor, Ph.D., a postdoctoral researcher in Chakravarti's laboratory, "so we catalogued all 200 that we found." The team then went through a process of elimination using genetically engineered, lab-grown cells and zebra fish to identify a variant in the noncoding DNA that affected how much protein was made by the nearby NOS1AP gene.

Next, they cultured rat heart cells and engineered them to overproduce NOS1AP. When the concentration of the protein rose in a particular type of heart cell called a cardiomyocyte, the cells' electrical properties changed in a way that is similar to the pattern seen in long QT syndrome.

Kapoor notes that 67 percent of the general population carries the NOS1AP-overproducing genetic variant. "We have observed that NOS1AP genetic variants are associated with sudden cardiac death whether or not they affect a particular person's QT interval, raising the risk by about 40 percent," he says. Chakravarti notes that the results also add to scientific understanding of how the heart and QT interval work knowledge with far-reaching implications. For example, many drugs developed for noncardiac conditions have turned out to temporarily lengthen QT interval, a side effect that only turns up after much time and money are spent on drug development. By better understanding regulation of the QT interval, researchers would be better able to predict what types of drugs could affect it.

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Quantity, not quality: Risk of sudden cardiac death tied to protein overproduction

What what role does MSG play in obesity and fatty liver disease?

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PUBLIC RELEASE DATE:

27-May-2014

Contact: Vicki Cohn vcohn@liebertpub.com 914-740-2156 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, May 27, 2014The commonly used food additive monosodium glutamate (MSG) has been linked to obesity and disorders associated with the metabolic syndrome including progressive liver disease. A new study that identifies MSG as a critical factor in the initiation of obesity and shows that a restrictive diet cannot counteract this effect but can slow the progression of related liver disease is published in Journal of Medicinal Food, a peer-reviewed journal from Mary Ann Liebert, Inc.. The paper is available on the Journal of Medicinal Food website.

Makoto Fujimoto and a team of international researchers from Japan, the U.S., and Italy monitored the weight gain and development of nonalcoholic fatty liver disease and its progression to nonalcoholic steatohepatitis in MSG-treated mice fed either a calorie-restricted or regular diet. They report their findings in the article "A Dietary Restriction Influences the Progression But Not the Initiation of MSG-Induced Nonalcoholic Steatohepatitis".

"Although MSG has been deemed a safe food additive, its dosage, interaction with other drugs, effects on vulnerable populations, and effects on chronic inflammatory diseases and neurological diseases are unknown," says Co-Editor-in-Chief Sampath Parthasarathy, MBA, PhD, Florida Hospital Chair in Cardiovascular Sciences, University of Central Florida, Orlando, in the Editorial "How Safe is Monosodium Glutamate? Exploring the Link to Obesity, Metabolic Disorders, and Inflammatory Disease" . The findings by Fujimoto et al. "may have far reaching implications, as childhood obesity is a major problem across the globe."

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About the Journal

Journal of Medicinal Food is an authoritative, peer-reviewed, multidisciplinary journal published monthly in print and online. Led by Editors-in-Chief Sampath Parthasarathy, MBA, PhD, and Young-Eun Lee, PhD, Wonkwang University, Jeonbuk, Korea, this scientific journal for leaders of the nutraceutical and functional foods revolution publishes original scientific research on the bioactive substances of functional and medicinal foods, nutraceuticals, herbal substances, and other natural products. The Journal explores the chemistry and biochemistry of these substances, as well as the methods for their extraction and analysis, the use of biomarkers and other methods to assay their biological roles, and the development of bioactive substances for commercial use. Tables of content and a free sample issue may be viewed on the Journal of Medicinal Food website.

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What what role does MSG play in obesity and fatty liver disease?

Obama Quizzes Kid Geniuses at White House Science Fair

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President Barack Obama quizzed students on their robots, electric cars, genetic discoveries and other projects at the White House science fair, highlighting the administrations push to boost science, technology, engineering and matheducation.

U.S. companies have lamented a shortfall of workers trained in so-called STEM fields, and the government officials want to boost enrollment in such programs.

These are the fields of the future, Mr.Obama said.This is where the good jobs are going to be.

As part of the fair, Mr. Obama announced $35 million in Department of Education grants to support training of more science, engineering and math teachers, an expansion of the AmeriCorps STEM program and a mentoring plan to link tech workers with students.

The White House said 100 students from more than 30 states came to the fair.On the same day of a major announcement about Afghanistan, a call with Ukraines president-elect and developments in policy toward Syria, the president spent more than an hour visiting with some of the students and asking them about award-winning projects.

Were so proud of you, Mr. Obama told 18-year-oldElana Simonof New York City. Ms. Simon, who survived a rare form of liver cancer, discovered a link between a common genetic mutation and the illness.

Peyton Robertson, a 12-year-old from Fort Lauderdale, Fla., developed a sandless sandbag to help protect against flooding. When dry, my bags are really lightweight, they weigh only four pounds, Mr. Robertson told the president. But then when you add water it expands and becomes heavy, it weighs 30 pounds.

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Obama Quizzes Kid Geniuses at White House Science Fair

Carpenter Graduates from Air Force Academy, Commissioned as 2nd Lieutenant

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Andrew Carpenter, a 2010 Garnet Valley High School graduate, will be graduating from the United States Air Force Academy in Colorado Springs, Colorado on May 28th with a degree in Behavioral Science. The three day festivities include graduation with the Thunderbird flyover, commissioning into the Air Force as a 2nd Lieutenant, the Superintendents Reception, a military ball and a final parade. Andrews father, retired United States Navy Commander, will be commissioning his son into the Air Force as an officer.

While at the academy, Andrew received his jump wings after completing five solo jumps and after flight training completed his solo in a plane. He served as baseball team manager and was the guidon for his squadron, carrying his squadrons colors in marches and at formal occasion. He participated in a Portugal Language Immersion Summer Program and enjoyed his junior fall semester as an exchange student to the Naval Academy in Annapolis. He has consistently maintained Deans List for academics and earned the Athletic Directors List for outstanding physical fitness. He ran his first marathon at the academy.

At graduation, Andrew has been selected to lead his squadron at their final parade as Flight Commander. After graduation, Andrew will receive a sixty day leave and will be travelling with academy friends to Europe and Hawaii. He has been selected to attend flight school and will begin training in Pueblo, Colorado and then Columbus, Mississippi. His family includes John and Susan Carpenter of Garnet Valley, Jennifer, of Austin, Texas and Eric in Richmond, Virginia.

While at the academy, Andrew received his jump wings after completing five solo jumps and after flight training completed his solo in a plane. He served as baseball team manager and was the guidon for his squadron, carrying his squadrons colors in marches and at formal occasion. He participated in a Portugal Language Immersion Summer Program and enjoyed his junior fall semester as an exchange student to the Naval Academy in Annapolis. He has consistently maintained Deans List for academics and earned the Athletic Directors List for outstanding physical fitness. He ran his first marathon at the academy.

At graduation, Andrew has been selected to lead his squadron at their final parade as Flight Commander. After graduation, Andrew will receive a sixty day leave and will be travelling with academy friends to Europe and Hawaii. He has been selected to attend flight school and will begin training in Pueblo, Colorado and then Columbus, Mississippi. His family includes John and Susan Carpenter of Garnet Valley, Jennifer, of Austin, Texas and Eric in Richmond, Virginia.

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Carpenter Graduates from Air Force Academy, Commissioned as 2nd Lieutenant

Breakthrough shows how DNA is ‘edited’ to correct genetic diseases

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PUBLIC RELEASE DATE:

26-May-2014

Contact: Philippa Walker 44-117-928-8086 University of Bristol

An international team of scientists has made a major step forward in our understanding of how enzymes 'edit' genes, paving the way for correcting genetic diseases in patients.

Researchers at the Universities of Bristol, Mnster and the Lithuanian Institute of Biotechnology have observed the process by which a class of enzymes called CRISPR pronounced 'crisper' bind and alter the structure of DNA.

The results, published in the Proceedings of the National Academy of Sciences (PNAS) today, provide a vital piece of the puzzle if these genome editing tools are ultimately going to be used to correct genetic diseases in humans.

CRISPR enzymes were first discovered in bacteria in the 1980s as an immune defence used by bacteria against invading viruses. Scientists have more recently shown that one type of CRISPR enzyme Cas9 can be used to edit the human genome - the complete set of genetic information for humans.

These enzymes have been tailored to accurately target a single combination of letters within the three billion base pairs of the DNA molecule. This is the equivalent of correcting a single misspelt word in a 23-volume encyclopaedia.

To find this needle in a haystack, CRISPR enzymes use a molecule of RNA - a nucleic acid similar in structure to DNA. The targeting process requires the CRISPR enzymes to pull apart the DNA strands and insert the RNA to form a sequence-specific structure called an 'R-loop'.

The global team tested the R-loop model using specially modified microscopes in which single DNA molecules are stretched in a magnetic field. By altering the twisting force on the DNA, the researchers could directly monitor R-loop formation events by individual CRISPR enzymes.

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Breakthrough shows how DNA is 'edited' to correct genetic diseases

Amazing Science – The Future of Assembly Lines (Manufacturing & Nanotechnology) – Video

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Amazing Science - The Future of Assembly Lines (Manufacturing Nanotechnology)
There #39;s no shortage of ideas about how to use nanotechnology, but one of the major hurdles is how to manufacture some of the new products on a large scale. W...

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Amazing Science - The Future of Assembly Lines (Manufacturing & Nanotechnology) - Video