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SolarVitis | Mibelle Biochemistry
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SINGAPORE - Under the treatment, a drug contained in millions of tiny capsules is injected into the eyeball. These nanomedicine capsules slowly release their contents over six months, replacing the need for daily eyedrops.
Get the full story from The Straits Times.
Here is the statement from the Nanyang Technological University:
Scientists from Nanyang Technological University (NTU) and the Singapore Eye Research Institute (SERI) have jointly developed a new nanomedicine that will allow glaucoma patients to do away with daily eye drops.
Glaucoma is a disease which could lead to blindness. This new sustained-release drug therapy can provide months of relief to glaucoma patients with a single application, compared to just hours with today's conventional eye drops.
The new therapy has successfully gone through a pilot study with six patients conducted at the Singapore National Eye Centre and has yielded exceptional results, having shown to be both safe and effective in the treatment of glaucoma.
A leading cause of blindness in the world especially for the elderly, glaucoma is caused by high intra-ocular pressure in the eye which then leads to damage to the optic nerve. Conventionally, the first line of treatment for glaucoma patients is the daily application of eye drops which can lower the high pressure in their eyes. This treatment is usually required for the rest of the patients' lives as glaucoma is a chronic disease.
Co-lead scientist Associate Professor Tina Wong, who is the head of the Ocular Therapeutics and Drug Delivery Research Group at the Singapore Eye Research Institute, said the new nanomedicine will benefit the elderly, as they often forget to use the daily eye drops, leading to the worsening of their conditions.
"It is estimated that at least ten per cent of blindness from glaucoma is directly caused by poor patient adherence to their prescribed medications," says Dr Wong, an Adjunct Associate Professor with NTU's School of Materials Science and Engineering.
"Many patients find it difficult to adhere to their doctor's prescribed regime for many reasons, such as forgetfulness, finding it too troublesome, or they lack understanding of the disease. The results in this clinical study will open up a new treatment modality for glaucoma other than taking daily eye drops, and will greatly enhance patient compliance and improve treatment outcomes," she said. Professor Tina Wong is also a senior consultant ophthalmologist with the Glaucoma Service at Singapore National Eye Centre.
See the original post here:
New glaucoma treatment replaces the hassle of applying eyedrops daily
PUBLIC RELEASE DATE:
3-Jun-2014
Contact: Lester Kok lesterkok@ntu.edu.sg 65-679-06804 Nanyang Technological University
Scientists from Nanyang Technological University (NTU) and the Singapore Eye Research Institute (SERI) have jointly developed a new nanomedicine that will allow glaucoma patients to do away with daily eye drops.
Glaucoma is a disease which could lead to blindness. This new sustained-release drug therapy can provide months of relief to glaucoma patients with a single application, compared to just hours with today's conventional eye drops.
The new therapy has successfully gone through a pilot study with six patients conducted at the Singapore National Eye Centre and has yielded exceptional results, having shown to be both safe and effective in the treatment of glaucoma.
A leading cause of blindness in the world especially for the elderly, glaucoma is caused by high intra-ocular pressure in the eye which then leads to damage to the optic nerve. Conventionally, the first line of treatment for glaucoma patients is the daily application of eye drops which can lower the high pressure in their eyes. This treatment is usually required for the rest of the patients' lives as glaucoma is a chronic disease.
Co-lead scientist Associate Professor Tina Wong, who is the head of the Ocular Therapeutics and Drug Delivery Research Group at the Singapore Eye Research Institute, said the new nanomedicine will benefit the elderly, as they often forget to use the daily eye drops, leading to the worsening of their conditions.
"It is estimated that at least ten per cent of blindness from glaucoma is directly caused by poor patient adherence to their prescribed medications," says Dr Wong, an Adjunct Associate Professor with NTU's School of Materials Science and Engineering.
"Many patients find it difficult to adhere to their doctor's prescribed regime for many reasons, such as forgetfulness, finding it too troublesome, or they lack understanding of the disease. The results in this clinical study will open up a new treatment modality for glaucoma other than taking daily eye drops, and will greatly enhance patient compliance and improve treatment outcomes," she said.
Read this article:
New nanomedicine by NTU and SERI scientists to bring relief to glaucoma patients
Agnosticism
Preaching the Gospel of "I don #39;t know"
By: Donnacha O #39;Driscoll
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Early dogs may have helped human hunters track and kill mammoths in Ice Age Europe and Asia. The fierce dogs may have then guarded the meat from their wolf relatives.
Penn State archeologist Pat Shipman recently calculated that the age ranges of mammoths found in these ancient boneyards suggest that the animals were hunted, not just scavenged after a catastrophe killed an entire herd.Shipman suggested that the domestication of wolves, along with improvements in projectile weapons, may have allowed people to successfully hunt large numbers of mammoths. The journal Quaternary International published her results.
From approximately 40,000 to 15,000 years ago, human campsites from Siberia to central Europe contained tremendous numbers of mammoth bones, sometimes from more than 100 individual pachyderms. In many cases, humans constructed buildings using the mammothbones, tusks and hides.
Shipman noted that high numbers of wild wolf and Arctic fox bones appear along with the mammoth bones. Dogs may have helped guard the mammoth meat by alerting people when other carnivores came sniffing around. The wolves and foxes were then killed and skinned for their pelts and meat.
Earlier archeological discoveries, published in the Journal of Archeological Sciences, described a breed of dog, or semi-domesticated wolf, from approximately 32,000 years ago in what is now Belgium, the Ukraine and Russia. Genetic and skeletal evidence show that the dog-like creature was different from known wolves, yet its genetic signature didnt survive in modern dog populations. This could mean the mammoth-hunting dogs either died out, or interbred with other dogs and wolves until they became indistinguishable.
Relatives of modern humans, including Neanderthals, likely hunted mammoths too. Chemical signatures in their bones suggest Neanderthals ate the extinct creatures. However, no known Neanderthal campsites contain the remains of hundreds of mammoth bones.
Photo: Wikipedia Commons
A primary area of focus in the bill this year is scientific research, innovation and competitiveness. Investing in basic research is key to growth and job creation, and it is the foundation for the economic security of future generations which enables us to stay ahead of China. So said Frank Wolf (R-VA), Chairman of the House Commerce, Justice, Science Appropriations Subcommittee at the start of two days of deliberations by the House on an FY 2015 bill to fund a wide range of federal agencies, including NASA, National Institute of Standards and Technology, National Oceanic and Atmospheric Administration and the National Science Foundation.
The House passed this legislation on Friday morning by a vote of 321-87. Although scores of amendments were offered the bills provisions regarding the four science agencies were left largely unchanged.
While there was discussion about the appropriateness of some NSF grants, the partisan divisions seen at last weeks House Science Committeemarkupof their FIRST bill were much less apparent. Chaka Fattah (D-PA), Ranking Member on the Commerce, Justice Science Appropriations Subcommittee saidAs for the Democrats, I want to say a number of things. One if that we are very pleased that in this bill the science accounts have been a focus of high priority.
The subcommittee wrote the FY 2015 bill under difficult circumstances. Overall funding was about $400 million less than the current level. In the last five fiscal years the subcommittee has cut total spending by $13.3 billion or 20 percent. Thisbill, H.R. 4660, is the last that Wolf will be writing as he is retiring at the end of this Congress.
Grants made by NSFs Social, Behavioral, and Economics (SBE) Directorate were discussed as was the foundations grant making process. In introducing his bill, Wolf said,With increased funding comes increased responsibility. I respect the NSF to follow through on the commitments it has made to the committee to increase accountability and transparency in its grant decision making. No funny grants is what I am trying to say. The new director must take every necessary step to ensure that research grants are scientifically meritorious, that funding allocations reflect national priorities and that the taxpayer investments in science are being used wisely. Later in the debate, House Majority Leader Eric Cantor (R-VA) and House Science Committee Chairman Lamar Smith (R-TX) offered an amendment to reduce the bills FY 2015 funding for the SBE directorate by $15.4 million, resulting in level funding of $256.9 million. This funding would be shifted to NSF physical science and engineering grants. The amendment passed by a vote of 208-201.
The bills funding level for NOAAs Office of Oceanic and Atmospheric Research was increased by $12 million under a successful amendment offered by Rep. Jim Bridenstine (R-OK). Arguing that the increased money would accelerate R&D and the development of new technologies, Bridenstines amendment shifted the money from the Census Bureau. Both Wolf and Fattah supported the amendment and it passed the House by a vote of 340-71. In announcing his support for the amendment, Wolf described H.R. 4660s strong funding for the National Weather Service, explaining the bills appropriation was $16 million above the Obama Administrations request. The bill also provided funding above the Administrations requests for information technology officers, the Hurricane Forecast Improvement Program, and a tsunami community education awareness program.
Efforts to increase funding for NOAAs climate research programs were unsuccessful. Rep. Rush Holt (D-NJ) sponsored an amendment to shift $37.5 million, within the bills appropriation for NOAA, to maintain the current level of funding. Explained Holt:This bill would cut critical investments that are needed for ongoing climate research, and failing to provide the resources necessary to study our changing climate wont make the problem go away; it will just make it harder to predict and more difficult to understand. Denial is the result of ignorance and only deepens our ignorance. We need to support the science behind climate change. We need to develop policies that would help us mitigate and adapt to the threats of climate change. Four of Holts Democratic colleagues offered lengthy remarks supporting the amendment but it was rejected on a voice vote. Rep. Suzanne Bonamici (D-OR) offered an amendment to fully fund the administration request for NOAAs Integrated Ocean Acidification research program but she withdrew it before a vote was called.
Other science-related amendments discussed on the floor included one by Rep. Marcy Kaptur (D-OH) to move $7 million in NASA funding from space operations to space technology. It was accepted by House members. The House rejected an amendment offered by Rep. Dan Kildee (D-MI) to shift $10 million from NASAs Exploration program to an international trade enforcement program. An amendment by Rep. Paul Broun (R-GA) to reduce NSFs FY 2015 appropriation by $67 million was rejected by voice vote. Rep. Matt Salmons (R-AZ) amendment to eliminate NSF funding for research on climate change impacts on Chinese tea was accepted by voice vote. Another amendment that would have affected specific NSF research grants was ruled out of order.
Action now shifts to Senate appropriators. Today Commerce, Justice, Science Appropriations Subcommittee Chairwoman Barbara Mikulski (D-MD) and her colleagues approved their version of the FY 2015 bill. It will be considered by the full committee, which she also chairs, on Thursday.
See the article here:
House Passes FY 2015 Funding Bill for NASA, NIST, NOAA, and NSF
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