Horizons reloaded ep23 Start of the genetic engineering.
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Horizons reloaded ep23 Start of the genetic engineering. - Video

Genetic engineering might eliminate malaria!
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/ 06.06.2014 02:55PM

Quantel to Color Finish 4K 60p FIFA World Cup

Pablo Rio and Genetic Engineering 2 tapped

The Quantel GE2 system, which includes two Pablo Rio 4KO color correction and finishing systems sharing storage and workflow via a GenePool, will be used for the production of fast-turnaround 4K highlights packages. These will be distributed to broadcasters and Sony Stores worldwide as well as being displayed on 4K super-screens in fan parks around Brazil. The Quantel system will also be used for the post production of the Official FIFA World Cup film in 4K Ultra HD.

Pablo Rio runs on high-performance PC hardware and exploits Nvidia Maximus multi-GPU technology to deliver interactivity and productivity. Pablo Rio is available as software-only and as a range of Quantel-backed turnkey systems. Genetic Engineering 2 provides shared storage and workflow for up to four Pablo Rio systems.

The Quantel system will work with 4K 60p XAVC media recorded on either the Sony PMW-F55 cameras being used by FIFA Film crews throughout the competition or the Sony Servers used for the 4K live production of three matches played at the Maracana Stadium in Rio de Janeiro (one in the round of 16, one quarter final and the final itself). All XAVC media will be instantly available for viewing and editing on the Pablo Rio color and finishing systems thanks to their ability to begin work immediately with soft-mounted media without transcoding or importing. The Quantel system will also record live 4K 60p via Quad 3G SDI, which can be edited while recording. The Pablo Rios will be equipped with Fraunhofer IISs integrated easyDCP toolset for production of cinema deliverables.

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Quantel to Color Finish 4K 60p FIFA World Cup

TIME Health Heart Disease

Doctors, and especially doctors who do research, dont like to use the words cure or eradicate. They know how dangerous that can be, since the human body is so unpredictable. But Dr. Kiran Musunuru is showing some uncharacteristic swagger about his latest success in lowering heart attack risk among some lucky mice.

Taking advantage of advances in genetic engineering, a team lead by Musunuru, who holds positions at Harvard Universitys Department of Stem Cell and Regenerative Biology and Brigham and Womens Hospital, have edited the genomes of mice and successfully protected them from heart disease. The results, published in the journal Circulation Research, hint at an entirely new way of avoiding the leading killer of Americans by possibly cutting heart attack risk by up to 90%. What has me excited as a cardiologist is that my goal is eradicating disease, says Musunuru. There is no bolder way I can put it. I want to eradicate the disease and this offers one potential way to do it.

MORE: Experimental Cholesterol-Lowering Drug Shows Promise

He admits that it may be 10 years or more before the technique is ready for testing in people, but these first results are enough to justify the research that could make that happen. This approach in general will be a game changer, says Dr. Deepak Srivastava, director of cardiovascular disease and stem cell biology and regenerative medicine at the Gladstone Institutes, who was not affiliated with the study.

Heres how they did it. In 2003, genetic information was gleaned from a French family that carried a genetic mutation giving them low LDL cholesterol, the kind that, when its high, can lead to heart disease. Using a new genetic engineering technique that allows scientists to splice more efficiently into specific locations on a genome, Musunuru was able to essentially bestow the genetic advantage from the French family onto his mice, slowing down production of a protein that normally keeps LDL circulating in the blood. With less of the protein around, less LDL remains in the blood; those with the PCSK9 mutation showed as much as an 88% lower risk of heart disease compared to people without the genetic change.

The genetic monkeying was accomplished with the help of a virus, which has a remarkable ability to get into cells. The virus was injected, along with the DNA-disrupting machinery, into the liver of the mice. Within days, more than half of the liver cells had been genetically edited and the mice showed 35% to 40% less cholesterol in the blood.

So far, says Musunuru, there have been no negative effects of the genetic disruption. But he says more research needs to be done to make sure that introducing the changes wont come with unforeseen consequences. When we go in there we want to make sure we are not introducing new spelling errors in the genome, says Srivastava, who is also using the technique for stem-cell based therapies to treat heart disease. Says Musunuru, I think I can confidently say that with this tool, this technology will work on live, breathing human beings, but we need to figure out the safety; thats the barrier to overcome before we can test these therapies.

MORE: Who Really Needs To Take a Statin?

Drug companies are also working on drug-based ways to interfere with PCSK9, and lower LDL levels, but those therapies are antibodies that bind to the protein that the gene makes and need to be injected, at a doctors office, regularly. The genome editing strategy would be a one-stop therapy that could permanently protect against excessively high cholesterol levels.

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A Vaccine for Heart Disease Could Mean No Pills, Lettuce or a Gym