Graduate Entry Medical School Official Launch with Minister for Finance Michael Noonan – Video


Graduate Entry Medical School Official Launch with Minister for Finance Michael Noonan
Minister for Finance, Michael Noonan TD, officially launched the award-winning Graduate Entry Medical School at the University of Limerick, 23 June 2014. The...

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Graduate Entry Medical School Official Launch with Minister for Finance Michael Noonan - Video

‘Begin Again’ | Anatomy of a Scene w/ Director John Carney | The New York Times – Video


#39;Begin Again #39; | Anatomy of a Scene w/ Director John Carney | The New York Times
John Carney narrates a musical sequence from his film "Begin Again." Produced by: Mekado Murphy Subscribe to the Times Video newsletter for free and get a ha...

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UCLA Awarded $7 Million to Unravel Mystery Genetic Diseases

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Newswise The David Geffen School of Medicine at UCLA is one of six institutions nationwide chosen by the National Institutes of Health to join their effort in tackling the most difficult-to-solve medical cases and develop ways to diagnose rare genetic disorders. Part of a $120 million initiative called the Undiagnosed Diseases Network, the four-year $7.2 million UCLA grant will enable comprehensive bedside to bench clinical research to support physicians efforts to give long-sought answers to patients who have been living with mystery diseases.

Undiagnosed diseases take a huge toll on patients, their families and the health care system, said Dr. Katrina Dipple, a co-principal investigator of the grant with Drs. Stanley Nelson, Christina Palmer and Eric Vilain. This funding will accelerate and expand our clinical genomics program, enabling us to quickly give patients a firm diagnosis and clarify the best way to treat them.

Despite extensive clinical testing by skilled physicians, some diseases remain unrecognized because they are extremely rare, underreported or atypical forms of more common diseases. An interdisciplinary team of geneticists at each of the network sites will examine and study patients with prolonged undiagnosed diseases.

A vast number of children and adults suffer from severe, often fatal undiagnosed disorders, explained Vilain. This program will enable us to discover new genes causing ultra-rare medical conditions and to identify environmental factors that lead to disease or interact with genes to cause disease.

Patients will undergo an intensive week-long clinical assessment that includes a clinical evaluation, consultations with specialists and medical tests, including genome sequencing to identify genetic mutations. The team will also evaluate the impact of genetic counseling and genomic test results on patients and families to develop best practices for conveying this information.

The Undiagnosed Diseases Network capitalizes upon the strengths of UCLAs genetic medicine program, particularly its Clinical Genomics Center, which utilizes powerful sequencing technology to diagnose rare genetic disorders. Using a simple blood sample from a patient and both parents, the test simultaneously searches 37 million base pairs in 20,000 genes to pinpoint the single DNA change responsible for causing a patients disease. To date, a specific genetic explanation has been identified in a quarter of the cases evaluated with this test, as well as a number of novel disease-causing genes.

UCLA is the only facility in the western U.S. and one of only three nationwide that has a laboratory that can perform genomic sequence directly usable for patient care. The UCLA Medical Genetics Clinic cares for more than 750 new patients per year, and offers comprehensive pre- and post-test genetic counseling.

All patient studies will take place on the university campus at the Clinical Translational Research Center of the Clinical and Translational Science Institute. Network investigators will share genomic and clinical data gleaned from patients with their research colleagues nationwide to enhance understanding of rare and unknown diseases.

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UCLA Awarded $7 Million to Unravel Mystery Genetic Diseases

Scientists engineer nanoparticles to prevent bone cancer, strengthen bones

PUBLIC RELEASE DATE:

30-Jun-2014

Contact: Marjorie Montemayor-Quellenberg mmontemayor-quellenberg@partners.org 617-534-6383 Brigham and Women's Hospital

Boston, MA A research collaboration between Brigham and Women's Hospital (BWH) and Dana-Farber Cancer Institute (DFCI) has utilized nanomedicine technologies to develop a drug-delivery system that can precisely target and attack cancer cells in the bone, as well as increase bone strength and volume to prevent bone cancer progression.

The study is published the week of June 30, 2014 in Proceedings of the National Academy of Sciences.

"Bone is a favorable microenvironment for the growth of cancer cells that migrate from tumors in distant organs of the body, such as breast, prostate and blood, during disease progression," said Archana Swami, PhD, BWH Laboratory of Nanomedicine and Biomaterials, co-lead study author. "We engineered and tested a bone-targeted nanoparticle system to selectively target the bone microenvironment and release a therapeutic drug in a spatiotemporally controlled manner, leading to bone microenvironment remodeling and prevention of disease progression."

"There are limited treatment options for bone cancers," added Michaela Reagan, PhD, DFCI Center for Hematologic Oncology, co-lead study author. "Our engineered targeted therapies manipulate the tumor cells in the bone and the surrounding microenvironment to effectively prevent cancer from spreading in bone with minimal off-target effects."

The scientists developed stealth nanoparticles made of a combination of clinically validated biodegradable polymers and alendronate, a clinically validated therapeutic agent, which belongs to the bisphosphonate class of drugs. Bisphosphonates bind to calcium. The largest store of calcium in the human body is in bones, so bisphosphonates accumulate in high concentration in bones.

By decorating the surface of the nanoparticles with alendronate, the nanoparticles could home to bone tissue to deliver drugs that are encapsulated within the nanoparticles and kill tumor cells, as well as stimulate healthy bone tissue growth. Furthermore, bisphosphonates are commonly utilized during the treatment course of cancers with bone metastasis, and thus alendronate plays a dual role in the context of these targeted nanoparticles.

The scientists tested their drug-toting nanoparticles in mice with multiple myeloma, a type of bone cancer. The mice were first pre-treated with nanoparticles loaded with the anti-cancer drug, bortezomib, before being injected with myeloma cells. The treatment resulted in slower myeloma growth and prolonged survival. Moreover, the researchers also observed that bortezomib, as a pre-treatment regimen, changed the make-up of bone, enhancing its strength and volume.

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Opinion: The Soul of Man under Secularism

(Kumar Ketkar is a senior journalist, political commentator, globe trotter and author. He has covered all Indian elections since 1971 and significant international events. He is a frequent participant on TV debates.)

The title of this piece, paraphrased from Oscar Wilde's 'The Soul of Man Under Socialism' would contradict the very essence of the idea of 'Secularism'. The secularists are not supposed to believe in the existence of 'soul'. It is presumed that they have scientific temper and do not believe in any prevailing religion. They may have been born to some religion - Hindu, Muslim, Christian, Sikh etc, but they profess to be secularists. The secularists are either atheists or at least agnostics.

But the Indian version, or rather the Congress version of secularism is essentially respect (or appease) all religious communities. That is why it was translated by a section of Indian intellectuals as "Sarva-Dharma-Samabhava". It tried to emphasize co-existence and tolerance of all faiths, rather than scientific temper or agnosticism / atheism. Under this system, all religions are allowed to not only practice publicly but also propagate their religious beliefs. The pragmatic and politically convenient definition of "secular" is just being "anti-communal".

The otherwise sober Congress leader A K Anthony has stirred a hornet's nest by openly saying that Congress secularism has come to mean appeasement of the minorities. So the definition of secularism was not merely anti-communalism but being overtly pro-minorities. It hardly needs to be stressed that the term minorities is often used as synonymous for Muslims. Anthony himself is a Christian and therefore a member of the minority community. But despite being a Congressman, he too used the term appeasement to mean Muslims. It was the unkindest cut of all.

Actually, a similar critical comment was made by late Vithalrao Gadgil, the then spokesperson of the Congress, in 1998-1999, when the BJP-led NDA came to power, but it did not generate as much controversy. The debate has now reopened because Anthony is a head of the committee set up to investigate the causes of the disastrous defeat of the Congress. Also, the defeat in 1998-99 was not as catastrophic as now. It is natural therefore that the BJP and the conservative Hindu pundits have quickly taken up Anthony's statement and pounced on the rather vague idea of secularism as practiced by the Congress.

Oscar Wilde had observed, in the context of the idea of socialism that, "Admirable but misdirected intentions, they very seriously and very sentimentally set themselves to the task of remedying the evils, but their remedies do not cure the disease, they merely prolong it. Indeed their remedies are part of the disease". This observation aptly describes the fate of political secularism in the country today.

For the past 30 years or more, this form of secularism is under siege. Broadly, the organizations or parties believing in the idea of 'Hindutva' or 'Hindu Rashtra' were considered "communal" and hence all other parties, from the Congress to Communists, from Samajwadi Party to the BSP, were regarded as secular. Muslims are not a monolithic community, as most of the Sangh Parivar believes. In fact, the Shia Muslims are supposed to be with the BJP, even in Gujarat. The Bohra Muslims are openly backing Narendra Modi.

Psephologists say their research shows that the so-called Muslim Vote Bank is a media-created myth. The Uttar Pradesh election proves that even the Muslims voted the BJP in a significantly large number. However, there is a strong "secular" view that majoritarianism has prevailed and there was massive Hindu vote consolidation. It is also true that there is tremendous apprehension about this election and there is a lot of fear, frustration and a feeling of getting reduced to secondary citizenship.

For the first time the number of Muslim members of Parliament has been reduced to a single digit. The BJP does not have a single Muslim MP. The only Muslim minister, Najma Heptulla is a non-elected member of the party, and she has complicated the issue of "minority community" by saying that only the Parsis can be considered a minority. Even the Parsis were not impressed by Najma's statement.

Those people who have visited Gujarat feel the state and the so-called development model have not reached out to the Muslims in refugee camps. Modi often says "all are Indians " and he does not distinguish between Tamilians and Punjabis, Bengalis and Marathis. The experience of Gujarat is that it is psychologically divided. There is a huge "trust deficit" between the state government and the Muslim community. It is also easy to say that the people, mainly the Muslims, must "move on" and not keep the injury of 2002 bleeding. Gujarat has a very bloody history of communal riots and just because some intellectuals and pundits want to "move on" does not mean the Muslims will be persuaded to believe a new era of "genuine secularism" has arrived after nearly 60 years of "pseudo-secularism".

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Nancy Kress: How Science Fiction Helps Us Rehearse for the Future

Stephen Cass: Hello, Im Stephen Cass for IEEE Spectrums Techwise Conversations.

Nancy Kress is a celebrated author of science fiction and fantasy novels and short stories. First published in 1976, her work often focuses on the implications of genetic engineering and other biomedical technologies. Among other awards, she has won five Nebulas from the Science Fiction & Fantasy Writers of America.

As part of its 50th anniversary celebrations this August, Spectrum will be publishing Coming Soon Enough, an anthology of six original science fiction stories, including one by Kress titled Someone to Watch Over Me. But you dont have to wait to read it: The story is available now as part of Spectrums June special issue about the long-term future of technology.

Without giving anything away, Someone to Watch Over Me is a dark tale about the unintended consequences of advanced biomedical implant technology. To talk about the story and the broader themes that run throughout her work, Kress joins us now by phone from her home in Seattle. Nancy, welcome to the podcast.

Nancy Kress: Thank you. Im glad to be here.

Stephen Cass: So what was the inspiration for Someone to Watch Over Me?

Nancy Kress: I often write about children. The next generation of any society is, of course, what carries it forward. But in addition, we are faced right now with so many interesting possibilities, with genetic engineering and in other technologies as well, that the generation being born now is growing up far different than, say, the way I did. Texting, to me, would have seemed unimaginable. To them, its just normal ho-hum everyday kind of things. So when I was thinking about this story, I was thinking about cameraswhich, of course, are a far next generation of Google Glassthat actually fit in the eye and are not noticeable to anybody else or even possibly to the wearer, except in that they are recording. I naturally turn to the idea of a child wearing one, and I asked myself, What child? Under what circumstances? And from there the story grew. I frequently do start with a character.

Stephen Cass: So how closely do you then follow real-world technological developments? You mentioned Google Glass, which is an emerging technology

Nancy Kress: Im not trained as a scientist, which I deeply regret. When I was in high school, I didnt have chemistry because it conflicted with French 4, and now I cant do chemistry or speak French. It was a great tragedy. However, I try to keep up with the journals that are written for laymen, and when something captures my attention, Ill try to get the latest books on it. And I also collect microbiologists the way some people collect butterflies.

And I have a list of people that I can ask questions of when something captures my attention. So its kind of hit and miss whether some emergent technology comes to my attention. But if it does, and if it also succeeds in capturing that attention, then I try to find out about it in anyplace thats available to me.

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Editorial: Fanning GMO fears

Published: Wednesday, July 2, 2014 at 6:01 a.m. Last Modified: Tuesday, July 1, 2014 at 4:29 p.m.

Genetic engineering is such a polarizing topic that it is hard to have an even-handed debate of the issue.

Some opponents of genetically modified organisms, or GMOs, spread false claims about safety while ignoring the vast amount of research to the contrary.

That frustrates University of Florida researchers who have made advances in genetic engineering that might provide benefits in fighting crop diseases and reducing the need for pesticides if they could get beyond public misconceptions.

As The Sun reported this week, UF researchers have taken a gene found in bell peppers and transferred it to tomatoes. The process has made tomatoes that are resistant to a particularly troublesome crop disease and have a higher yield.

Contrary to scare stories about Frankenfoods, these methods represent a more technologically advanced way of doing the kind of crop breeding that has happen for millennia.

But Florida tomato growers worry they wouldn't be able to sell a GMO product, hampering the ability of researchers to attract investors.

"People are afraid, they don't understand why, they are just told they should be," Sam Hutton, a UF plant scientist involved in the research, told The Sun. "The anti-GMO crowd screams really loud, and there is a lot of fearmongering. It sounds bad to people who don't understand the science."

Other GMOs being developed at UF include a strawberry that can be grown without fungicides. A researcher involved in that effort told The Sun that the crop likely won't go beyond the lab without a change in public attitudes.

"You have solutions that can help the environment, help farmers and help people in the developing world, and you can't use it," said Ken Folta, professor and chairman of UF's Horticultural Sciences Department.

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Editorial: Fanning GMO fears