Dr. Steven Knope debates Andrew Weil on the merits of Integrative Medicine Part I – Video


Dr. Steven Knope debates Andrew Weil on the merits of Integrative Medicine Part I
Dr. Steven Knope debates Andrew Weil on integrative medicine theories, techniques, and the use of LSD for medical treatment. http://clikhere.co/y45mO2sh.

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Dr. Steven Knope debates Andrew Weil on the merits of Integrative Medicine Part I - Video

DGAP-News: MagForce AG: Successful final closing of a growth financing round for MagForce USA, Inc. under the lead of …

DGAP-News: MagForce AG / Key word(s): Private Equity MagForce AG: Successful final closing of a growth financing round for MagForce USA, Inc. under the lead of Mithril Capital Management

08.08.2014 / 14:00

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MagForce AG: Successful final closing of a growth financing round for MagForce USA, Inc. under the lead of Mithril Capital Management

Berlin, Germany, August 8th, 2014 - MagForce AG (Frankfurt, Entry Standard, XETRA: MF6, ISIN: DE000A0HGQF5), a leading medical device company in the field of nanomedicine focused on oncology, today announced that its subsidiary MagForce USA, Inc. has successfully closed its growth financing round. Mithril Capital Management, a growth-stage technology fund founded by Ajay Royan and Peter Thiel, led a group of strategic investors including the management in financing MagForce USA's growth round with proceeds of USD 15 million, with an option to increase the size of the round to USD 30 million. MagForce AG owns 77% of MagForce USA as of this closing. The strategic investors presently hold 23% of MagForce USA and may increase their ownership in future by exercising the warrants held by them. After all warrants are exercised, MagForce AG will continue to retain a majority ownership position in MagForce USA.

MagForce USA, Inc., has been granted a license by MagForce AG for the development and commercialization of NanoTherm(TM) Therapy for the treatment of brain and prostate cancers and will be responsible for developing the North American market (US, Mexico and Canada) for MagForce's technology and products. Under the prostate cancer license, MagForce USA will also receive royalties for the sale of NanoTherm(TM) particles for the treatment of prostate cancer outside North America.

Ben J. Lipps, Chairman and CEO of MagForce AG and also of MagForce USA, Inc., commented: "I am very optimistic about the US market, which has the largest potential especially for prostate cancer treatment. MagForce USA aims at developing its technology to offer a new focal treatment for Intermediate Stage Prostate Cancer with precise ablation of the cancer lesion while sparing normal tissue. In Mithril, we have found the right collaborator to support our expansion plans. Ajay Royan and Peter Thiel have proven themselves numerous times to be valuable partners in helping companies unlock long-term growth."

Ajay Royan, co-founder and managing general partner of Mithril, said: "Conventional treatments for prostate cancer have significant side effects and other limitations, while patients with glioblastoma currently have few good options at all. That's why MagForce's innovative approach to solid tumors is very promising and potientially important."

About MagForce AG and MagForce USA, Inc. MagForce AG, listed in the entry standard of the Frankfurt Stock Exchange (MF6, ISIN: DE000A0HGQF5), together with its subsidiary MagForce USA, Inc. is a leading medical device company in the field of nanomedicine focused on oncology. The Group's proprietary NanoTherm(TM) therapy enables the targeted treatment of solid tumors through the intratumoral generation of heat via activation of superparamagnetic nanoparticles. NanoTherm(TM), NanoPlan(R), and NanoActivator(R) are components of the therapy and have received EU-wide regulatory approval as medical devices for the treatment of brain tumors. MagForce, NanoTherm, NanoPlan, and NanoActivator are trademarks of MagForce AG in selected countries. For more information, please visit: http://www.magforce.com. Please learn more: video (You Tube)

About Mithril Capital Management Mithril is a global investment firm that provides capital to leading growth companies by partnering with teams who use technology to build transformative and durable businesses, often in industries long overdue for change. Each of these businesses is unique, but all face common challenges to unlocking long-term growth. Mithril helps navigate these critical inflection points by investing in size and with conviction. For more information, please visit: http://www.mithril.com

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DGAP-News: MagForce AG: Successful final closing of a growth financing round for MagForce USA, Inc. under the lead of ...

Jeffrey Smith’s ‘challenge’ to Neil deGrasse Tyson EVISCERATED (part 1) – Video


Jeffrey Smith #39;s #39;challenge #39; to Neil deGrasse Tyson EVISCERATED (part 1)
On August 5th, Jeffrey Smith, the creator of the #39;Institute for Responsible Technology #39; issued a challenge to Neil deGrasse Tyson. In it, he displays a TITANIC lack of knowledge on the topic...

By: Jeff Holiday

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Jeffrey Smith's 'challenge' to Neil deGrasse Tyson EVISCERATED (part 1) - Video

Researchers to track effects of revolutionary new medicines

PUBLIC RELEASE DATE:

4-Aug-2014

Contact: Jamie Brown jamie.brown@liverpool.ac.uk 44-151-794-2248 University of Liverpool

The University of Liverpool has been awarded 2 million to become a leading centre in the UK for tracking the fate in the body of materials used in breakthrough medicines.

Researchers will be using radioactive labelling to find out where key materials used in nanomedicines go once the medicines have entered the body.

Nanomedicines are a relatively new class of therapy which can deliver small quantities of a drug in a targeted way to the affected part of the body. Unlike traditional therapies, nanomedicines are formulated to use lower quantities, with the potential for cost savings, fewer side-effects and more rapid treatment of disease.

Part of nanomedicine formulations involve the use of polymers or other materials which help the drug reach its target, but until now there has been little research into where the carrier materials accumulate, despite them often making up over half of the mass of the medicine.

The Liverpool Radiomaterials Chemistry Laboratory at the University will 'tag' parts of the medicines by making some of them harmlessly radioactive and then monitor how they move around the body once drugs are administered. The process of making the polymers radioactive won't alter their chemical composition, so the nanomedicines can be studied pre-clinically without changing how they work.

Chemist, Professor Steve Rannard, said: "Nanomedicines have been used widely in cancer treatment where side-effects are often weighed against the short time span of treatment and the urgency of the condition.

"However they are now being increasingly studied for chronic conditions where treatment can go on for decades. This raises questions about where materials go and how they leave the body during long-term exposure."

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Genetically modified crops: Ignoring genetic engineering at our own peril

Some British newspapers have been reporting the imminent harvest of a variety of nutrition-enriched genetically modified (GM) crop in the UK. It is a crop called camelina, also called false flax, a plant that usually grows in the Mediterranean. An institute called Rothamsted Research has tweaked the plant's genes and produced a variety that is full of omega-3 fatty acids, normally found only in oily fish.

Consumption of omega-3 fatty acids is supposed to be beneficial in a number of ways, and so this crop would provide the first real chance for vegetarians to get the vital nutrient through their normal diet. This would be great news for many people, but what is equally important is the fact that GM crops are set to finally break the resistance in Europe.

Despite considerable opposition from various pressure groups, GM crops are slowly advancing in Europe, with regulators relenting in several countries. Two months ago, almost all the environment ministers in Europe - only two countries resisted - decided to let individual countries follow their own course: whether to allow or not allow the cultivation of GM crops.

This will let the pro-GM countries go ahead with their plans, which will probably force the rest to consider GM crop trials and commercial launches. For some time now, Europe is cited as a model - often wrongly - to those around the world to resist commercial cultivation and even research in GM crops.

If Europe cultivates GM crops on a large scale, resistance will slowly reduce in China and African countries, and later in India as well. All these countries have so far seen some resistance against GM crops. China, despite funding GM crop research, has been reluctant to commercialise these widely.

Africa has been uneven in its acceptance, with countries like South Africa being adopters and other countries like Tanzania and Kenya holding out. India commercialised Bt cotton more than a decade ago, but progress of GM crops in the country has been slow since then.

From a scientific viewpoint, genetic engineering is like atomic energy; it depends on how you use it. So while it is difficult to say that all GM crops are bad, there could be situations where they would do some damage, depending on the genes that one chooses to introduce.

Most of the genes being tried now are known to be safe. It is highly unlikely that they will cause damage to our agricultural system, but it is impossible to prove it the other way.

The only option is to put them through trials, and then proceed with caution if they seem to be safe. One shouldn't judge the merit of a gene based on where it came from. We all have bacterial genes in our bodies. Not conducting field trials, as is often advocated in India and some other countries, will backfire at some point.

Sometime in the future, countries that resist GM crops will begin to see their benefits elsewhere, and then face a situation where they have to adopt when faced with an agricultural disaster. It is almost certain that humanity will find it difficult to feed everybody by mid-century without some serious technological advances.

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Genetically modified crops: Ignoring genetic engineering at our own peril

Is the gut microbiome a potential cause and therapeutic target for autoimmune diseases like multiple sclerosis?

PUBLIC RELEASE DATE:

7-Aug-2014

Contact: Kathryn Ryan kryan@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News

Numerous risk factors are believed to contribute to the development of autoimmune disorders such as multiple sclerosis, and new research is focusing on the role that bacteria in the gastrointestinal tract as well as other cell stress-related chemical signals could have in stimulating inflammation in the central nervous system and activating immunostimulatory cytokines. Two comprehensive Review articles are part of a focus on "Cytokines in Neuroinflammation and Immunity" in a special issue of Journal of Interferon & Cytokine Research (JICR), a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The articles are available free on the JICR website.

Kiel Telesford and Lloyd Kasper, Geisel School of Medicine at Dartmouth University (Lebanon, NH) and Javier Ochoa-Repraz, University of California-Santa Barbara, describe three key characteristics of the gut microbiome related to immune cell activity and cytokine production that may be relevant to susceptibility to and treatment of autoimmune disorders such as multiple sclerosis. In the article "Gut Commensalism, Cytokines, and Central Nervous System Demyelination," the authors note that our understanding of the biology of the gut microbiome and the immunoregulatory potential of bacteria and parasites in the gut is still in its infancy.

In the Review article "Interferons, Signal Transduction Pathways, and the Central Nervous System," Shreeram Nallar and Dhan Kalvakolanu, University of Maryland School of Medicine, Baltimore, explore in detail the latest research pointing to the role of cytokines, and in particular interferons, in contributing to the development of diseases affecting the central nervous system. The authors discuss the potential effects of either an excess or lack of interferons, the inflammatory effects of cytokines, and new therapeutic research strategies.

"The communications between the microbial community in the gut and the host immune system is turning out to be remarkably complex and is likely to impact on many aspects of both health and disease," says Editor-in-Chief Thomas A. Hamilton, PhD, Chairman, Department of Immunology, Cleveland Clinic Foundation, Ohio.

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About the Journal

Journal of Interferon & Cytokine Research (JICR), led by Editors-in-Chief Ganes C. Sen, PhD, Chairman, Department of Molecular Genetics, Cleveland Clinic Foundation, Ohio, and Thomas A. Hamilton, PhD, is an authoritative peer-reviewed journal published monthly online with Open Access options and in print that covers all aspects of interferons and cytokines from basic science to clinical applications. JICR, celebrating 35 years of publication in 2015, is an official journal of the International Cytokine & Interferon Society. Complete tables of content and a sample issue may be viewed on the JICR website.

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Is the gut microbiome a potential cause and therapeutic target for autoimmune diseases like multiple sclerosis?

Expert insights on in vitro alternatives for drug and chemical toxicity testing

PUBLIC RELEASE DATE:

7-Aug-2014

Contact: Kathryn Ryan kryan@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, August 7, 2014In vitro toxicity testing is rapidly being adopted in the pharmaceutical, chemical, and cosmetics industries, for example, as an alternative to animal studies to predict adverse health effects of drugs and personal care products and the health consequences of environmental exposures. An insightful Roundtable Discussion focused on how to apply these novel toxicology models to everyday hazard prediction, risk assessment, and decision making in industry is published in the preview issue of the new journal Applied In Vitro Toxicology, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The article is available free on the Applied In Vitro Toxicology website.

In the Roundtable Discussion "Comments on How to Make the New Vision of Toxicity Testing in the 21st Century a Reality," Moderator Jim McKim, Editor-in-Chief of Applied In Vitro Toxicology and Founder and CEO, IONTOX, LLC, challenges the panelists to present a realistic view of how far the field has advanced in implementing the strategy put forth in a National Academy of Sciences report to improve toxicity testing.

Panelists Alan Goldberg, Consulting Editor of the Journal, Nicole Kleinstreuer, ILS/National Toxicology Program Interagency Center for Evaluation of Alternative Toxicological Methods (Research Triangle Park, NC), Francois Busquet, Center for Alternatives to Animal Testing (Konstanz, Germany), and Melvin Andersen, The Hamner Institutes for Health Sciences (RTP, NC) participate in an interactive discussion on the use of human cell models combined with high-throughput screening methods to test for toxicity, and the complexity of applying adverse outcome pathways (AOPs). The conversation covers topics ranging from policy issues, challenges related to data interpretation and understanding the information gained from in vitro models, the emergence of three-dimensional tissue culture models that integrate cells from multiple human organs, and the different approaches being used to assess risk from high-dose, short-term exposures compared to exposure to lower concentrations of a chemical over longer periods of time.

"Improved analytical technologies and improvements in human tissue models will allow us to change the animal safety testing paradigm," says Jim McKim.

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About the Journal

Applied In Vitro Toxicology is a new peer-reviewed journal providing the latest research on the application of alternative in vitro testing methods for predicting adverse effects in the pharmaceutical, chemical, and personal care industries. Led by Editor-in-Chief James M. McKim, PhD, DABT, IONTOX, LLC, the Journal addresses important issues facing these diverse industries, including regulatory requirements; the reduction, refinement, and replacement of animal testing; new screening methods; evaluation of new cell and tissue models; and the most appropriate methods for assessing safety and satisfying regulatory demands. The Journal is published quarterly online with Open Access options and in print. A sample issue may be viewed on the Applied In Vitro Toxicology website (http://www.liebertpub.com/aivt).

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Expert insights on in vitro alternatives for drug and chemical toxicity testing

Insights from the Behavioral Science Guy: Here's one of the most powerful ways to improve the moral character of our …

Joseph Grenny asks: If lying is the natural order of things, how can people behave unnaturally and tell the truth?

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A few years ago, my colleagues and I did an experiment to test what induces people to lie or tell the truth. Click here (registration required) to see the full experiment.

One of our subjects was 15-year-old Jake, a high school basketball star. We invited Jake to toss beanbags through holes of various sizes in a plywood target. He scored six out of a possible 15 points (not too good for a basketball phenom). As Jake approached our table to report his score, we wondered would he embrace his shame and tell the truth? Or would he lie to get the extra $1 per point we promised him?

We all lie. And if you dont believe that, youre probably lying to yourself. Studies have shown that lying is actually the natural order of things. From the time we are small, we learn there are powerful incentives to modify how we appear and to control the information we share with others.

So, given the importance of trust to healthy relationships, families and communities, how can we help people do the unnatural? How can we, in spite of all the immediate incentives to do the opposite, influence people to tell the truth?

Turns out, simply changing the way we communicate can be a powerful way to influence greater honesty.

Psychologist Bella DePaulo from UC Santa Barbara estimates that the average person tells three lies every 10 minutes. We lie about how we feel. We strategically edit our opinions to fit the group were chatting with. We select which parts of ourselves to reveal or suppress in order to create particular impressions. We overstate (or, if were trying to avoid an assignment, understate) our competence. We frequently feign powerlessness in order to exit conversations Sorry, Ive got to go! (A. Are you really sorry? And B. What is forcing you to go? Someone holding your cat hostage, perhaps?)

Our proclivity to lie begins early. Once we did an experiment in which we randomly assigned 3-year-olds to drink either a small cup of sweet, delicious orange juice or a similar cup tainted with salt. The salt was so strong that the tykes puckered involuntarily. Immediately after they drunk the juice, we asked the child to look into the camera and say, as convincingly as they could, Yum! This is great juice! You should try some. We videotaped the performances and then showed them to adults asking them to guess which tots were fibbing. Few could spot the liars. At age 3, the kids had learned the basics of lying. They knew enough to look sincerely into the camera, smile and in other ways fake emotion they didnt really feel.

Now back to the beanbag toss. In the first round of our experiment, we asked teenagers to report their own scores (which we verified using a hidden camera), and we paid them $1 for each point. Eighty percent of the subjects lied. Some of them lied by more than 200 percent. And ironically, many of these kids had just finished a Bible study class.

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Insights from the Behavioral Science Guy: Here's one of the most powerful ways to improve the moral character of our ...

New Glycan Creams, Micronutrient Creams Hold Promise for Reducing the Signs of Aging Skin

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Newswise For decades, dermatologists have been researching the genetic cause of aging skin so that the perfect antidote could be developed. When examining genes and proteins, a difference between younger and older looking skin has not been found. Now, dermatologists have a new theory the secret to aging skin may lie in the glycans, which are sugars on the surface of cells.

Board-certified dermatologist Zoe Draelos, MD, FAAD, consulting professor at Duke University School of Medicine, Durham, N.C., addresses the latest developments in anti-aging, including glycan creams and micronutrient creams.

What is the theory behind glycans and anti-aging, and how do glycan creams work? Dr. Draelos said a persons glycan levels change during their lifetime. For example, one of the bodys most common glycans is glucose, and Dr. Draelos said glucose levels fall by about 50 percent from age 30 to age 60. In addition, existing glycans may not work as well as they once did.

The theory is that glycan change and loss that occur with aging lead skin cells to not recognize or communicate with each other with the same vigor they did in their youth, said Dr. Draelos. This may be why aging skin doesnt heal as well or make collagen as readily as it once did, said Dr. Draelos.

Dr. Draelos said the goal of glycan creams is to provide sugars or transform existing sugars to allow older cells to behave like younger cells. In theory, this would allow the skin to produce more collagen and heal better after injuries, including burns and cuts. Dr. Draelos notes one added benefit of glycan creams is that they are considered safe to apply to the skin because sugars are the bodys fuel.

However, Dr. Draelos notes current research has not shown if glycan creams can impact the skin to the extent that skin cell glycans begin to act more youthful. The theory behind glycans impact on anti-aging is very much in its infancy, said Dr. Draelos. Currently there are other more proven treatments on the market, such as retinoids, but new research will provide additional targets for anti-aging strategies.

Are there broader implications of this research? Weve known for a long time that sugars are important to the body as they are used to distinguish normal cells, which should be preserved, from infected cells, cancer cells, or any cell that is not quite right and should be destroyed, said Dr. Draelos.

Dr. Draelos said glycans might hold the secret not just to aging of the skin, but to other changes that occur within the body. Every cell in the body has sugars on it, so Dr. Draelos said glycan therapies could have a role in preventing and treating cancer and infections as well as skin conditions.

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New Glycan Creams, Micronutrient Creams Hold Promise for Reducing the Signs of Aging Skin

Role of Integrative Medicine Video – Brigham and Womens Hospital – Video


Role of Integrative Medicine Video - Brigham and Womens Hospital
Donald B. Levy, MD, Medical Director, Osher Clinical Center for Integrative Medicine at Brigham and Women #39;s Hospital, defines integrative medicine: a philosophy of healing that focuses on...

By: Brighamandwomens

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Role of Integrative Medicine Video - Brigham and Womens Hospital - Video