Combining antibodies, iron nanoparticles and magnets steers stem cells to injured organs

Study published in Nature Communications details targeted nanomedicine therapy to regenerate heart muscle injured by heart attack

LOS ANGELES Researchers at the Cedars-Sinai Heart Institute infused antibody-studded iron nanoparticles into the bloodstream to treat heart attack damage. The combined nanoparticle enabled precise localization of the body's own stem cells to the injured heart muscle.

The study, which focused on laboratory rats, was published today in the online peer reviewed journal Nature Communications. The study addresses a central challenge in stem cell therapeutics: how to achieve targeted interactions between stem cells and injured cells.

Although stem cells can be a potent weapon in the fight against certain diseases, simply infusing a patient with stem cells is no guarantee the stem cells will be able to travel to the injured area and work collaboratively with the cells already there.

"Infusing stem cells into arteries in order to regenerate injured heart muscle can be inefficient," said Eduardo Marbn, MD, PhD, director of the Cedars-Sinai Heart Institute, who led the research team. "Because the heart is continuously pumping, the stem cells can be pushed out of the heart chamber before they even get a chance to begin to heal the injury."

In an attempt to target healing stem cells to the site of the injury, researchers coated iron nanoparticles with two kinds of antibodies, proteins that recognize and bind specifically to stem cells and to injured cells in the body. After the nanoparticles were infused into the bloodstream, they successfully tracked to the injured area and initiated healing.

"The result is a kind of molecular matchmaking," Marbn said. "Through magnetic resonance imaging, we were able to see the iron-tagged cells traveling to the site of injury where the healing could begin. Furthermore, targeting was enhanced even further by placing a magnet above the injured heart."

The Cedars-Sinai Heart Institute has been at the forefront of developing investigational stem cell treatments for heart attack patients. In 2009, Marbn and his team completed the world's first procedure in which a patient's own heart tissue was used to grow specialized heart stem cells. The specialized cells were then injected back into the patient's heart in an effort to repair and regrow healthy muscle in a heart that had been injured by a heart attack. Results, published in The Lancet in 2012, showed that one year after receiving the stem cell treatment, heart attack patients demonstrated a significant reduction in the size of the scar left on the heart muscle.

Earlier this year, Heart Institute researchers began a new study, called ALLSTAR, in which heart attack patients are being infused with allogeneic stem cells, which are derived from donor-quality hearts.

The process to grow cardiac-derived stem cells was developed by Dr. Marbn when he was on the faculty of Johns Hopkins University. Johns Hopkins has filed for a patent on that intellectual property and has licensed it to Capricor, a company in which Cedars-Sinai and Dr. Marbn have a financial interest. Capricor is providing funds for the ALLSTAR clinical trial at Cedars-Sinai. Recently, the Heart Institute opened the nation's first Regenerative Medicine Clinic, designed to match heart and vascular disease patients with appropriate stem cell clinical trials being conducted at Cedars-Sinai and other institutions.

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Combining antibodies, iron nanoparticles and magnets steers stem cells to injured organs

If I Stay (Chlo Grace Moretz, Jamie Blackley) | Anatomy of a Movie – Video


If I Stay (Chlo Grace Moretz, Jamie Blackley) | Anatomy of a Movie
Subscribe to Anatomy of a Movie #39;s YouTube Channel @ http://youtube.com/anatomyofamovie In this AOM show, hosts Marisa Serafini, Sara Stretton, and Demetri Panos discuss If I Stay which is...

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IBM’s ‘Ninja Particles’ could stop the rise of superbugs

IBM Research's Jim Hedrick has a great job. His work on polymers -- those repeating chains of macromolecules that make up most things in our world, like the computer or phone you're reading this on -- has led to the creation of substances with Marvel Comics-worthy descriptors. There's the self-healing, Wolverine-like substance that arose from a recycled water bottle and something called "ninja particles" that'll advance the reality of nanomedicine. Both discoveries will inevitably make their way into consumer products in the near future, but it's his team's progress on nanomedicine that Hedrick discussed during my visit to IBM Research's sprawling Almaden lab in San Jose, California.

The inspiration for IBM's foray into nanomedicine is twofold: our growing resistance to antibiotics and the incidence of medical-implant rejection by the human body. With this in mind, Hedrick and his team, leveraging IBM's background in semiconductor research, developed synthetic polymers that mimic the immune system. Using a simple charge, these resultant polymers are capable of hunting down and clinging to specific microbes throughout the body. And, once attached, cause those microbes to rupture as if they'd been hit by an explosive shuriken (or ninja star) -- hence, the name.

Of course, anyone who's seen Innerspace knows there's a certain danger to injecting foreign objects into your body. But Hedrick says we have nothing to worry about. The ninja particles won't pass into other parts of the body. They're also proven to have a low toxicity and, best of all, won't engender a new wave of resistant pathogens (read: superbugs). So when will see the practical fruits of IBM's research? Well, Hedrick tells us the company's already in talks with various partners to apply this nanotech to our modern world in anything from medicine to the deodorant we use daily to the detergents we use to wash our clothes and kitchenware. And that future's not too far off, either -- Hedrick believes we could begin to see these ninja particle-infused products hit retail within a decade's time.

Watch Hedrick explain how IBM's research into ninja particles can help revolutionize the health care industry.

Stay tuned for part three of our inside look at IBM's Almaden research facility.

[Image credit: Laguna Design/Getty]

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IBM's 'Ninja Particles' could stop the rise of superbugs

Profiles International Chief Science Officer to Present Keynote at International Talent Assessment and Development …

Waco, TX. (PRWEB) September 11, 2014

Talent management solutions provider, Profiles International, announced that Dr. Scott Hamilton, chief science officer at Profiles International, will address hundreds of global business leaders as he hosts certification training, and offers a keynote presentation to attendees at the 2nd International Talent Assessment and Development Conference.

The 2nd International Talent Assessment and Development Conference (ITADC2014) will take place at the Pullman Saigon Center in Ho Chi Minh City, Vietnam, on September 11 and 12.

The event is hosted by Profiles International South East Asia, and managed by National Director Rick Yvanovich. Dr. Scott Hamilton and Deiric McCann, executive vice president of the International Division at Profiles International, will both be featured as keynote speakers.

The ITADC is an annual conference with the goal and mission of helping organization leaders optimize their HR function, boost sales performance, and improve leadership skills. Leaders from around the world will attend and share their knowledge on issues faced by executive leaders, HR specialists, and sales managers. The second annual event of its kind, the conference features three days of presentations and networking.

A highlight of the event will be certification training that outlines all elements of the science behind employment assessments, while attendees will learn from how to utilize assessments for maximum impact in their own organization from Dr. Hamilton himself.

Attendees will also be treated to a personal session titled, "A Psychologist Looks at Leadership Styles in Business."

Learn more by visiting http://www.profilesinternational.com, or http://itadc2014.profiles-sea.com/.

ABOUT PROFILES INTERNATIONAL Profiles International is the best source for talent management solutions, with over 20 years' experience and more than 40,000 clients in over 120 countries. Profiles knows how people work and what motivates them. Their data-driven talent management solutions--built on complex behavioral science, yet simple to administer and read--help organizations find the right people, shape them into a winning team, and lead them to their full potential. http://www.profilesinternational.com

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ONCOblot blood test for cancer goes international

PUBLIC RELEASE DATE:

11-Sep-2014

Contact: Rebecca Davis info@oncoblotlabs.com ONCOblot Labs

West Lafayette, IN September 11, 2014 The ONCOblot Test, a highly sensitive blood test for cancer, has now expanded into international territories; bringing much needed support for early cancer detection to areas beyond The United States.

ONCOblot believes that these two new alliances with the WA Health Clinic and RCLIN SA will not only increase the awareness of choice and availability of cancer screenings, but offer more hope through a more definitive cancer diagnosis.

The WA Health Care is based out of China with laboratories in Shanghai and Beijing. Their innovative clinic treats patients through bringing medical doctors, professors and scientists in the fields of anti-aging medicine, functional medicine and regenerative medicine together. Through this, WA Health Care provides true focus on the patient as a whole, not just their symptoms. By looking at patients as humans, and not merely the sum of their symptoms, WA Health Care is perfectly aligned with ONCOblot's mission.

RCLIN SA is based out of Switzerland and has clinics in Geneva, Moscow, Kiev and Warsaw. RCLIN's mission is to help patients extend their life and maintain their health. They do this through finding and removing the causes of aging and disease, and by offering patients personalized solutions based on the latest scientific achievements. Their personalized approach is what created such an ideal connection for the ONCOblot Test.

With the combined influence and partnership of both health care facilities, ONCOblot is poised to deftly navigate previously unexplored territories and bring cancer screening awareness to more and more people each day.

The ONCOblot Test is a key component to treating cancer because it gives patients and physicians the insights for successful cancer management. Never before has one test been able to detect cancer on such a microscopic level and provide so much knowledge for early intervention and on-going management. ONCOblot looks forward to spreading this knowledge to territories across the globe.

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ONCOblot blood test for cancer goes international

The Aivee effect

Dr. Aivee Teos newest clinic combines multi-faceted skin typing with essential treatments to get The Aivee Glow

August 28, 2014The Aivee Clinic officially launches at the SM Mega Fashion Hall. After five years since opening her posh clinic at the Fort, Dr. Aivee Teo elevates her passion for advanced skin care technology and anti-aging treatments with the new clinic concept, The Aivee Clinic. The beauty hub couldnt have been in a better locationstationed alongside global fashion brands. Dr. Aivee Teo, one of the countrys most sought after dermatologists, after all, has as much passion for beauty as she has for fashion. Her success in the business of skin care is widely known, and as a fashion lover, she has constantly been on best-dressed lists. Beauty and fashion truly go hand in hand.

What started out as a practice in the pursuit of beauty, one that thrived purely on word of mouth, has inevitably made Dr. Aivee as one of the major players in the industry. Getting healthy, blemish-free, and luminous skin using non-invasive or minimally invasive methods has always been her technique. And she continues to push the standards with a full integration of beauty and wellness with The Aivee Group.

AIVEE LEAGUE

What is The Aivee Glow? Its a signature look defined as a luminous, radiant, and natural beauty that transcends external perfection. With the new clinic, Dr. Aivee strengthens the four pillars of The Aivee Group: The Aivee Institute (first class center for advanced dermatology, cosmetic surgery, hair restoration, and aesthetic stem cell therapy), Stemcare Institute (premiere center for pain and regenerative medicine using fat stem cells), Aivee Skin Science (research center for developing cosmeceutical and nutriceutical products) and now, The Aivee Clinic (skin-focused approach for no-downtime treatments). The Aivee Group is one well-oiled machine, with all its parts complementing each other toward a holistic beauty goal.

GRADE A

Its no secret that the husband and wife partnership of Dr. Z and Aivee Teo, their love and commitment for each other and their field, has brought them happiness and success. From surviving a long-distance relationship, shuffling back and forth Manila and Singapore to attend to their respective clinics, and always pursuing new ways to rejuvenate skin and provide a sense of well-being. All this while keeping their children close by and rarely being separate from each other. And if youve ever had the privilege of interviewing them together, they really finish each others sentences. Whether thats about their practice or about how they commit to make everything work for their family and business.

This dynamic duo established their anti-aging institute over a decade ago, utilizing maintenance procedures, non-invasive lasers, cutting edge technology such as stem cell therapy and liquid face lifts, and cosmetic surgery. The awareness of the growing needs of their patients and their recent travels to the US and Europe brought them to a new realization. With patients requesting for dramatic makeover programs, twice-a-year rejuvenation therapies and innovative treatments with the least amount or no downtime, SmartSkin became the clear answer as the way to move forward.

The SmartSkin Typing concept is a multi-faceted system with a digital tailor-made evaluation of the skin. By assessing and categorizing skin as oily or dry, sensitive or resistant, pigmented or non-pigmented, wrinkled or tight, you come up with a very specific skin type. From this, a highly customized skin treatment can easily be made. In keeping with the holistic approach, skin experts at The Aivee Clinic can then set the appropriate treatment programprocedures, health supplements, and skin careto achieve that healthy glow.

SKIN TECH

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The Aivee effect

Usher Syndrome Family Panel – What are your plans for the future? – Video


Usher Syndrome Family Panel - What are your plans for the future?
July 19th, 2014 - Usher Syndrome Family Conference at Harvard Medical School To see the full transcript of the panel and more videos, go here: http://flightforsight.co/wordpress/2014-usher-syndro...

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What Is The Definition Of Atkins diet Medical Dictionary Free Online – Video


What Is The Definition Of Atkins diet Medical Dictionary Free Online
what is the definition of Atkins diet: A high-protein, high-fat, low-carbohydrate weight-loss diet popularized by Dr. Robert C. Atkins that allows for unrestricted amounts of meat, cheese and...

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TransHuman Hybrids : The Beast System – Immortality of Mind and Body – Video


TransHuman Hybrids : The Beast System - Immortality of Mind and Body
The End of Ends The Day of Judgement is near for our entire cosmos will soon be terminated, putting an end to our meaningless efforts, and our futile obsessi...

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TransHuman Hybrids : The Beast System - Immortality of Mind and Body - Video