Author Archives: ev1

Can we bring animals back from extinction? – THE BIG FUTURE – Video

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Can we bring animals back from extinction? - THE BIG FUTURE
Like in Jurassic Park, genetic engineering might allow us to save endangered species or even bring back extinct animals. Subscribe: http://www.youtube.com/subscription_center?add_user=theverge...

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Can we bring animals back from extinction? - THE BIG FUTURE - Video

Cafe Scientifique: Psychological Trauma and Resilience: Victim Rehabilitation & Trauma Psychiatry – Video

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Cafe Scientifique: Psychological Trauma and Resilience: Victim Rehabilitation Trauma Psychiatry
with Daryn Reicherter, MD, Clinical Associate Professor, Psychiatry Behavioral Science, Stanford University School of Medicine War crimes stemming from pol...

By: Stanford Blood Center

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Cafe Scientifique: Psychological Trauma and Resilience: Victim Rehabilitation & Trauma Psychiatry - Video

The Cutting Edge of Science, Homeopathy and Nanomedicine w/ Dana Ullman, MPH, CCH — Part I (of V) – Video

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The Cutting Edge of Science, Homeopathy and Nanomedicine w/ Dana Ullman, MPH, CCH -- Part I (of V)
A presentation at San Francisco #39;s prestigious Commonwealth Club (September 17, 2014). The body of evidence for homeopathy and nanopharmacology is so much larger than most people realize, ...

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Long-term treatment success using gene therapy to correct a lethal metabolic disorder

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PUBLIC RELEASE DATE:

9-Oct-2014

Contact: Kathryn Ryan kryan@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News @LiebertOnline

New Rochelle, NY, October 9, 2014Excessive and often lethal blood levels of bilirubin can result from mutations in a single gene that are the cause of the metabolic disease known as Crigler-Najjar syndrome type 1 (CNS1). A new gene therapy approach to correcting this metabolic error achieved significant, long-lasting reductions in bilirubin levels in a mouse model of CNS1 and is described in an Open Access article in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available on the Human Gene Therapy website at http://online.liebertpub.com/doi/full/10.1089/hum.2013.233.

In "Life-Long Correction of Hyperbilirubinemia with a Neonatal Liver-Specific AAV-Mediated Gene Transfer in a Lethal Mouse Model of CriglerNajjar Syndrome," Giulia Bortolussi and coauthors from the International Centre for Genetic Engineering and Biotechnology; Centro Studi Fegato, Fondazione Italiana Fegato; and University of Trieste (Trieste, Italy) and Charles University (Prague, Czech Republic), present details of the adeno-associated virus (AAV)-mediated gene therapy approach they used to correct the metabolic disorder that causes hyperbilirubinemia in CNS1. The researchers reported 70-80% reductions in plasma bilirubin levels early on among treated animals, with about 50% reductions maintained throughout the study. The authors compared the effectiveness of two delivery strategies: targeting the therapeutic gene directly to the liver or, preferably, to skeletal muscle. They discuss the implications of the different results they obtained with each approach.

"CNS1 is an outstanding model for in vivo gene therapy with easily measured and clinically relevant metabolic endpoints," says James M. Wilson, MD, PhD, Editor-in-Chief of Human Gene Therapy, and Director of the Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia.

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About the Journal

Human Gene Therapy, the Official Journal of the European Society of Gene and Cell Therapy, British Society for Gene and Cell Therapy, French Society of Cell and Gene Therapy, German Society of Gene Therapy, and five other gene therapy societies, is an authoritative peer-reviewed journal published monthly in print and online. Human Gene Therapy presents reports on the transfer and expression of genes in mammals, including humans. Related topics include improvements in vector development, delivery systems, and animal models, particularly in the areas of cancer, heart disease, viral disease, genetic disease, and neurological disease, as well as ethical, legal, and regulatory issues related to the gene transfer in humans. Its sister journals, Human Gene Therapy Methods, published bimonthly, focuses on the application of gene therapy to product testing and development, and Human Gene Therapy Clinical Development, published quarterly, features data relevant to the regulatory review and commercial development of cell and gene therapy products. Tables of contents and sample issues for all three publications may be viewed on the Human Gene Therapy website at http://www.liebertpub.com/hgt.

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Long-term treatment success using gene therapy to correct a lethal metabolic disorder

Q32. Are health care workers or people in other occupations at risk for HIV? – Video

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Q32. Are health care workers or people in other occupations at risk for HIV?
From the HIV Avatar Project, posted by the Department of Behavioral Science and Community Health at the University of Florida hiv-avatar-project.com http://b...

By: UF Behavioral Science and Community Health

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Q32. Are health care workers or people in other occupations at risk for HIV? - Video

NASA To Study Deep Space Behavioral Health and Performance Issues

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NASA's Human Research Program (HRP) will fund three proposals to help investigate questions about behavioral health and performance on future deep space exploration missions. Research like this may help astronauts as they venture farther into the solar system than ever before to explore an asteroid and, eventually, Mars.

The selected proposals are from three institutions in two states and will receive a total of about $3.2 million during a three-year period.

The three projects were selected from 11 proposals received in response to the research announcement "Human Exploration Research Opportunities - Behavioral Health and Performance." Science and technology experts from academia and government reviewed the proposals.

Two proposals will investigate neurobehavioral conditions and standardized behavioral measures relevant to exploration class missions. One proposal will evaluate the neurobehavioral effects of a dynamic lighting system on the International Space Station.

HRP research provides knowledge and technologies to reduce crew health and performance risks during space exploration.

It also develops potential countermeasures for problems experienced during space travel. Mission planners and system developers can use these potential countermeasures to monitor and mitigate the risks to crew health and performance.

While the program's research goals are to ensure astronauts living off the Earth safely complete their challenging space missions and preserve their long-term health, these same research studies can also lead to advancements in human health understanding and treatments for patients on Earth.

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NASA To Study Deep Space Behavioral Health and Performance Issues

MetroMD The HGH Clinic Announces A Better Process of Reducing Aging

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(PRWEB) October 10, 2014

MetroMD, a leading anti-aging clinic of Los Angeles, is making waves in Los Angeles with its flagship anti-aging treatments like PRP and HGH therapy. Platelet Rich Plasma or PRP Therapy and Human Growth Hormone or HGH Therapy is the two anti-aging treatment concepts introduced by MetroMD which have taken the wellness world by storm.Platelet Rich Plasma or PRP Therapy and Human Growth Hormone or HGH Therapy is the two anti-aging treatment concepts introduced by MetroMD which have taken the wellness world by storm.

Human growth hormone is a protein based peptide hormone secreted naturally in humans by the pituitary gland and is responsible for growth in children and adolescents. In adults, the growth hormones or HGH is responsible for cell reproduction, tissue regeneration and immune system functioning. It is also responsible for vitality, energy, metabolism and sexual performance in adults. After the age of 30, human HGH levels show a steady decline and after age of 40 the decline rate becomes rapid. This leads to feeling fatigued, low in energy levels, a loss in sexual libido and a weakened cardio-vascular system.

An HGH specialist at MetroMD elaborated Permanent fatigue, weight gain, loss of lean muscle mass and lowered sexual performance as well as sexual arousals are all classic symptoms of aging and it simply means the body has started its shut-down mechanism. With research it has been found that the condition is caused because of growth hormone deficiencies in body. So the cure has to be one which returns the hormone levels to the youthful levels. One way is to stimulate pituitary gland to secrete optimum HGH again and the other treatment method is to artificially inject bio-synthetic HGH in the body to remove the deficiency. This second treatment method is what the clinic provides and it is known as the Human Growth Hormone Therapy or in short, HGH Therapy.

Growth hormone therapy has proven immensely beneficial to those who have undergone the treatment. Children, who had stunted growth, gained a near normal growth and adults who have undergone HGH Therapy have shown remarkable improvement in their body composition, physical strength and sexual performance. A 50+ male undergoing HGH replacement treatment for the last five months was exuberant in its praise I felt energized from the day one. I no more feel that persisting fatigue and body pain and my libido shoots through the roof. Erectile deficiency was a thing of the past and I my abdominal fat just seems to melt away. I clearly gained lean muscle mass and my friends say I look 10 years younger now. I was skeptical earlier and thought I was trashing my money. But now I am a believer.

In aging women, human HGH replacement counters weight-gain problem which affects a lot of women in their middle age. Like men, they too experience a dip in libido levels by age 35-40 which is returned to normal levels with treatment. Facial wrinkles are replaced with a firm youthful skin. Hair quality too improves and in many cases, the treatment causes reverse of graying and hair loss. In both men and women, this therapy causes strengthening of the immune system which translates into improved life expectancy.

MetroMD has been a pioneer in human growth hormone treatment in Los Angeles and has treated hundreds of highly satisfied HGH deficiency patients so far. The clinics clientele include big names from Hollywood, American Music Industry, Sports, Authors, Socialites, Professionals, Business World and other walks of life. Medical Director of MetroMD, Dr Alex Martin has been involved in growth hormone treatment and anti-aging regenerative medicine research since 70s and in mid 90s. He launched his anti-aging clinic in Newport Beach California. He was among the first to initiate Growth hormone treatment for children who had a stunted growth due to growth hormone deficiency. Like Dr Alex Martin, MetroMDs Managing Director Devin Stone is also an expert in anti-aging treatment, stem cell research and regenerative medicine. MetroMDs key treatments include Stem Cell Therapy, PRP therapy, Laser Treatments, Smartlipo and HGH Therapy. All these treatments are associated with concepts of longevity, giving its patients a chance to live a highly active and healthy middle age and old age filled with fun and vigor of youth.

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MetroMD The HGH Clinic Announces A Better Process of Reducing Aging