Genetic engineering may undercut human diseases, but also could help restore extinct species, researcher says

Oct 17, 2014 by Alvin Powell In his talk, Adapting Species to a Changing World: The Potential of Genome Editing, Professor George Church spoke about his efforts to engineer a mammoth from its closest living relative, the African elephant, while also discussing the primary goal of such technology: improving human health. Credit: Ann Wang

Mammoth DNA in recovered cells frozen for thousands of years is likely too fragmented to clone an animal, according to Harvard geneticist George Church. So he's working instead to engineer one genetically from a close relative, the Asian elephant.

Genetic studies have shown that the Asian elephant is more closely related to the extinct mammoth than to its closest living relative, the African elephant. That provides scientists with the basic stock to build a mammoth, said Church, the Robert Winthrop Professor of Genetics at Harvard Medical School.

"The Asian elephant and the mammoth are really close, closer than the African elephant," Church said during a lecture yesterday. "We're assuming that the Asian elephant is basically right, a mutant [mammoth] that has a problem living at minus 50 C."

Church acknowledged there are important differences between the two animals and said current efforts are aimed at one key contrast: cold tolerance. Increasing that in Asian elephants would mean changing several traits, such as adding a double fur coat and a thick layer of fat to keep out the cold, and reducing ear size to cut heat loss. Church said researchers are testing possible changes in lab cultures and are still several years from trying them out in an elephant.

Church's mammoth work is part of a kaleidoscope of research efforts fueled by genetic engineering, he said. While health and medical goals are driving down the price of genome analysis and fostering the development of new technology, some of the most far-reaching applicationslike resurrecting the mammoth and other extinct creatureslie outside human health.

Another potential non-medical use involves using genetic engineering to manage existing species, such as building malaria resistance into mosquitoes to minimize the human suffering the disease causes, or "de-evolving" the herbicide resistance weeds develop over time to restore a herbicide's effectiveness.

Church spoke at the Harvard Museum of Natural History, one of the Harvard Museums of Science & Culture (HMSC). His presentation, "Adapting Species to a Changing World: The Potential of Genome Editing," was before a crowd of several hundred in a packed Geological Lecture Hall. He was introduced by HMSC Executive Director Jane Pickering.

Though much of Church's talk focused on "de-extinction" and the genetic engineering of species, he also discussed the primary goal of such technology: improving human health. With the cost of decoding the genome having dropped from $3 billion to $999, cheap, widespread genetic analysis may help people understand their risk for genetically influenced ailments. Rapid, portable analysis could be used in the environment to detect potential infectious agents, and in the doctor's office to guide more effective care.

Church acknowledged that many medical conditions have a complex genetic background and are influenced by several genessometimes even several hundred genesbut said there can be a relative handful that outstrip others in importance and so provide therapeutic targets. For example, height has been shown to be influenced by 700 genes, but just a couple, affecting growth hormone production and use, are known to have a sizeable effect on getting taller.

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Genetic engineering may undercut human diseases, but also could help restore extinct species, researcher says

Jerrold Meinwald wins National Medal of Science

University Photography file photo

Jerrold Meinwald, the Goldwin Smith Professor of Chemistry Emeritus, has received the National Medal of Science in chemistry.

Jerrold Meinwald, the Goldwin Smith Professor of Chemistry Emeritus, has received the National Medal of Science, the nations highest honor for achievement in science and engineering. Meinwald received the medal in chemistry; other awards were bestowed in behavioral and social sciences, biology, engineering, mathematics and physical sciences, the White House announced Oct. 3.

Over his long career, Meinwald, who joined Cornells faculty in 1952 as an instructor in chemistry, has made fundamental discoveries of how chemicals act as repellants and attractants between organisms. He and the late Thomas Eisner, a longtime friend and colleague who won the National Medal of Science in 1994, are credited with establishing the field of chemical ecology the science that deals with the many ways animals, plants and microorganisms chemically interact.

Its a very nice thing, Meinwald said of the award. Its maybe a representation of a growing interest in the field of chemical ecology.

Meinwalds research has involved the isolation and identification of biologically active compounds from insect and other arthropod sources; pheromone systems of some amphibian and mammal species; and identification of messenger molecules involved in such systems and the understanding of underlying signal transduction pathways.

Meinwald has helped decipher the intricate chemical strategies that insects use for a variety of activities: mating, location of food, protection of offspring and defense against attackers. Throughout his decades-long scientific partnership with Eisner, Eisner, a biologist, conducted most of the biological experiments, while Meinwald and his research group of undergraduates, graduate students and postdocs provided the essential chemical expertise.

Chemicals of unforeseen potential have been among Meinwalds findings over the years. He helped discover that birds and spiders reject fireflies because of lucibufagins, a family of steroids, which Meinwald isolated for the first time. These compounds have proved to have cardiotonic and antiviral effects, with potential therapeutic value for humans.

Meinwald began his career as a conventional organic chemist, he said, but moved on to do collaborative chemistry with Eisner. Meinwald is an active advocate for chemists who seek scientific partnerships outside of chemistry, whether in biology, physics or other fields.

My own award represents a career built in large part on collaboration, he said.

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Jerrold Meinwald wins National Medal of Science

8 Science-Backed Ways to Find Happiness

Everyone's looking for that elusive happiness, but science has got it figured out.

Are you happy? Many people struggle to answer that question. Everyones ultimate goal is to be happy, and they usually search for that elusive happiness in their own way. Some dig around for gold, believing that riches will plant a permanent smile on their faces. Others collect friendships, relishing in the constant activity of a vast social network.

Whatever your method, in the end we are all yearning for that feeling of happiness, of ultimate contentment. There are of course, many ways to attain it. Happiness is a very personal matter, but there are scientifically-proven ways to make yourself and your body feel better. Do yourself some good and try them out:

1. Create something, anything

We are becoming a society of purely consumers. From the moment we open our eyes, we turn on our phones to read (and consume) what others have produced, then we go to work, listening to music that have also been penned down by others. We watch charity videos and contribute by sharing a link on our page, not thinking to do anything else. Its an easy life. Convenient, entertaining, effortless. But there are also plenty of moments of emptiness, of feeling like you havent done anything of consequence.

The science

See, the reason we sometimes feel restless is because humans thrive on achievements. A study published in 2009 showed that mastering a skill may stress us out in the moment, but eventually gets us to a happier place.

Get happy

You dont have to create anything major, or bring peace to the universe. Start small, perhaps instead of buying herbs at the supermarket, start your own herb garden. Instead of just reading blogs, pen down some of your thoughts. Learn to paint and come up with your own masterpieces. Arrange for an outing instead of always waiting on your friends. The possibilities to create are endless!

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8 Science-Backed Ways to Find Happiness

New Frontier of Integrative Medicine – Robert J. Marshall (September 2014) – Video


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Exclusive: New figures reveal massive decline in religious affiliation

In five decades, the number of people with no religion in Britain has grown from just 3 per cent of the population to nearly half, according to a new survey. Among adults aged under 25, nearly two-thirds define themselves as "nones", or people with no religious affiliation.

The findings present an enormous challenge for the churches over how they make faith appealing to young people, in a world where many young will be appalled at how the male-dominated church leadership has made discrimination against women and homosexuals a defining feature of orthodox mission.

If the trends continue, Methodists will be extinct in a few decades and the Church of England also faces massive decline by the end of the century.

Only the Catholics are currently holding up, along with some minority faiths, in the mass move towards atheism and agnosticism in Britain.

Ben Clements of British Religion in Numbershas analysed the latest data from the first stage of the 2015 British Election Study, a survey of more than 20,000 people by a team of academics from Manchester, Oxford and Nottingham universities.

His results, posted on the British Religion in Numbers website, make for gloomy reading for most churches in the UK.

According to the results, nearly half the population, 44.7 per cent, now do not belong to any religion at all. Nearly a third identify as Church of England or Anglican and nearly one in ten as Catholic. Just 1.6 per cent identify as Muslim. Among those aged 18-24, just 14.2 per cent identify as Anglican, 8.5 per cent as Catholic and 11 per cent as other religion. Only among the over 65s are the numbers of Anglicans holding up, at 46.4 per cent.

The average age is highest for Anglicans, at 53.7 years, and lowest for those with no religion, 43.3 years, or a non-Christian faith, 42.2 years.

Clements reportsthat over the five decades from 1963, when the British Election Study began, to this summer, the major features are the resilience of Catholicism and a decline in Anglicanism and other Christian traditions. He also found a significant increase in those affiliated to minority faiths and the growth in what have become known as the "religious nones".

In 1963, Anglicans made up 64.5 per cent of those questioned, compared to 31.1 per cent this year. Other Christian denominations also declined from 23.1 per cent to 7.6 per cent, while other faiths grew from 0.6 per cent to 7.5 per cent and Catholics also grew from 8.6 per cent to 9.1 per cent.

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Exclusive: New figures reveal massive decline in religious affiliation

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A look at modern science that disproves and debunks all illuminati evolution lies. Quantum Physics, DNA, God Particle, Bible Codes all PROVE YESHUA JESUS IN HEBREW IS THE SON OF GOD.

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