PUBLIC RELEASE DATE:

11-Nov-2014

Contact: Yivsam Azgad news@weizmann.ac.il 972-893-43856 Weizmann Institute of Science @WeizmannScience

New Weizmann Institute research may bring the idea of sleep learning one step closer to reality. The research, which appeared today in The Journal of Neuroscience, suggests that certain kinds of conditioning applied during sleep could induce us to change our behavior. The researchers exposed smokers to pairs of smells - cigarettes together with that of rotten eggs or fish - as the subjects slept, and then asked them to record how many cigarettes they smoked in the following week. The study revealed a significant reduction in smoking following conditioning during sleep.

Dr. Anat Arzi in the group of Prof. Noam Sobel of the Weizmann Institute's Neurobiology Department had previously shown that associative conditioning - Pavlovian-type learning in which the brain is trained to subconsciously associate one stimulus with another - could occur during sleep if odors were used as the unconditioned stimulus. Though the volunteers did not remember the odors they had smelled in the night, their sniffing gave them away: The next morning they reacted unconsciously to tones that had been paired with bad smells by taking short, shallow breaths. The use of smell, explains Arzi, is central: As opposed to other types of sensory stimulus, even very bad odors do not wake us.

The current study was performed on 66 volunteers who wanted to quit smoking, but were not being treated for the problem. Cigarette smoking was chosen for the study because it is behavior that can be simply quantified and the target stimulus was another smell. After filling out questionnaires about their smoking habit, those in the sleep group spent a night in the department's special sleep lab, in which their sleep patterns were closely monitored. At certain stages of sleep, they were exposed to paired smells - cigarettes and a foul odor - one right after the other, repeatedly throughout the night. Although they did not remember smelling the odors the next morning, the subjects reported smoking less over the course of the next week. In contrast, subjects who were exposed to the paired smells when awake did not smoke less afterward, nor did sleepers who were exposed to cigarette smells and the two aversive smells unpaired, at random times.

The scientists noted that the group with the best results - an average of 30% fewer cigarettes - was comprised of those who had been exposed to the smells during stage 2, non-REM sleep. This supported the group's earlier findings which suggested that we mostly forget what happens in our dreams, but conditioning that makes its way into our subconscious during the "memory-consolidation" stage may stick.

Sobel and Arzi suggest that olfactory conditioning may be a promising direction for addiction research because the brain's reward center, which is involved in such addictive behavior as smoking, is closely interconnected with the regions that process smell. Some of these regions not only remain active when we sleep, the information they absorb may even be enhanced in slumber.

Arzi: "We have not yet invented a way to quit smoking as you sleep. That will require a different kind of study, altogether. What we have shown is that conditioning can take place during sleep, and this conditioning can lead to real behavioral changes. Our sense of smell may be an entryway to our sleeping brain that may, in the future, help us to change addictive or harmful behavior."

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Behavioral changes seen after sleep learning

FLEMINGSBURG | A Fleming County teacher has been named middle school science teacher of the year by the Kentucky Science Teacher Association.

Simons Middle School Science teacher Cindy Combs said she found out she had received the award in October, but only received it earlier this month.

"I was very excited," she said. "I'm very honored to have received this award."

The award is presented to one science teacher each year who shows a commitment to students and to current science standards.

'Enthusiastic, dependable, hard-working and helpful' have been used to describe Mrs. Combs as a teacher, commanding the respect of her administrators and peers," said a spokesperson from KSTA.

According to Combs, she had been nominated in previous years, but had not received the award.

"This year, I resubmitted by application and I won," she said.

Combs said she is from Laurel County, but moved to Morehead in order to attend Morehead State University, where she received her bachelor's degree and master's degree in education and behavioral science. She is National Board certified and a Project Lead the Way instructor.

She had not originally planned to teach science to older students, Combs said.

"I started as an elementary teacher," she said. "I began working my way up and realized I enjoyed teaching middle school students. But, what hasn't changed is my love for science. It has always been my passion."

See more here:
Combs named KSTA science teacher of the year