Dragon Quest IX Playthrough #123, The Observatory: Giving Up Immortality – Video


Dragon Quest IX Playthrough #123, The Observatory: Giving Up Immortality
This is video #123 in my playthrough of Dragon Quest IX: Sentinels of the Starry Skies. This video does not contain commentary. To view the commentary versio...

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Dragon Quest IX Playthrough #123, The Observatory: Giving Up Immortality - Video

How to Gymnastic Bridge Wheel Pose Muscle Anatomy Training Program EasyFlexibility – Video


How to Gymnastic Bridge Wheel Pose Muscle Anatomy Training Program EasyFlexibility
http://easyflexibility.com/products/back-bridge-upward-bow-wheel-pose-gymnastics-bridge Full Bridge is a strength/flexibility powerhouse. It requires flexibility in the shoulder joint, shoulder...

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How to Gymnastic Bridge Wheel Pose Muscle Anatomy Training Program EasyFlexibility - Video

‘Trojan horse’ proteins used to target hard-to-reach cancers

PUBLIC RELEASE DATE:

11-Dec-2014

Contact: Keith Coles keith.coles@brunel.ac.uk Brunel University @bruneluni

Scientists at Brunel University London have found a way of targeting hard-to-reach cancers and degenerative diseases using nanoparticles, but without causing the damaging side effects the treatment normally brings.

In a huge step forward in the use of nanomedicine, the research helped discover proteins in the blood that disguise nanoparticles so they are absorbed into cells without causing inflammation and destroying healthy cells.

Two studies, Complement activation by carbon nanotubes and its influence on the phagocytosis and cytokine response by macrophages and Complement deposition on nanoparticles can modulate immune responses by macrophage, B and T cells, found that carbon nanotubes (CNTs) triggered a chain reaction in the complement system, which is part of the innate immune system and is responsible for clearing pathogens and toxins.

The team, led by Dr Uday Kishore of the Centre for Infection, Immunity and Disease Mechanisms, found the entire complement system was activated, from C1 at the start to C5 at the end. This in turn activated the cell-killing membrane attack complex.

In principle, this should have caused an acute allergic, inflammatory reaction. However the opposite was true.

The interaction between CNTs and C1q (a starter-protein for complement) was anti-inflammatory. This suggests that either coating nanoparticles or healthy tissue with complement proteins could reduce tissue damage and help treat inflammatory diseases like Parkinson's, Huntington's, ALS and Alzheimer's.

It was not clear if the binding between complement proteins and CNTs was direct or indirect. However, changing the surfaces of CNTs affected how likely the complement system was to be activated and in what way.

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'Trojan horse' proteins used to target hard-to-reach cancers

Can a biomarker in the blood predict head fracture after traumatic brain injury?

PUBLIC RELEASE DATE:

11-Dec-2014

Contact: Kathryn Ryan kryan@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News @LiebertOnline

New Rochelle, NY, December 11, 2014--In cases of traumatic brain injury (TBI), predicting the likelihood of a cranial lesion and determining the need for head computed tomography (CT) can be aided by measuring markers of bone injury in the blood. The results of a new study comparing the usefulness of two biomarkers released into the blood following a TBI are presented in Journal of Neurotrauma, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Journal of Neurotrauma website at http://online.liebertpub.com/doi/full/10.1089/neu.2013.3245 until January 11, 2015.

The article "GFAP Out-Performs S100 in Detecting Traumatic Intracranial Lesions on Computed Tomography in Trauma Patients with Mild Traumatic Brain Injury and Those with Extracranial Lesions," describes a study of adult trauma patients with and without mild or moderate TBI. The authors, Linda Papa and colleagues from Orlando Regional Medical Center, North Florida Veteran's Health System and University of Florida (Gainesville), University of Central Florida (Orlando), Banyan Biomarkers Inc. (Alachua, FL), Virginia Commonwealth University (Richmond, VA), and Baylor College of Medicine (Houston, TX), showed that increased blood levels of glial fibrillary acidic protein (GFAP) following TBI was a good predictor of intracranial lesions, whether or not the patient had fractures elsewhere in the body. Whereas S100 levels in the blood of were significantly higher in trauma patients with fractures than without fractures, it was not as useful as GFAP in distinguishing between intracranial and extracranial lesions.

John T. Povlishock, PhD, Editor-in-Chief of Journal of Neurotrauma and Professor, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, notes that "This is an extremely important paper because of its relatively large sample size and its singular focus upon mild traumatic brain injury complicated by the presence of extracranial lesions. This study convincingly demonstrates the efficacy and brain specific nature of GFAP and its ability to detect traumatic intracranial lesions while also calling into question the overall utility of S100 in the same patient population. Importantly, the superior performance of GFAP in the mild brain injured population is an important observation consistent with other reports emerging in the field. Lastly, the observation that these GFAP elevations occur relatively early in a posttraumatic course speaks to the potential utility of using these biomarkers to screen brain injured patients who then may require more extensive and/or long term imaging studies."

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About the Journal

Journal of Neurotrauma is an authoritative peer-reviewed journal published 24 times per year in print and online that focuses on the latest advances in the clinical and laboratory investigation of traumatic brain and spinal cord injury. Emphasis is on the basic pathobiology of injury to the nervous system, and the papers and reviews evaluate preclinical and clinical trials targeted at improving the early management and long-term care and recovery of patients with traumatic brain injury. Journal of Neurotrauma is the official journal of the National Neurotrauma Society and the International Neurotrauma Society. Complete tables of content and a sample issue may be viewed on the Journal of Neurotrauma website at http://www.liebertpub.com/neu.

About the Publisher

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Can a biomarker in the blood predict head fracture after traumatic brain injury?

Q110 Can an employer require that a job applicant be tested for HIV? – Video


Q110 Can an employer require that a job applicant be tested for HIV?
From the HIV Avatar Project, posted by the Department of Behavioral Science and Community Health at the University of Florida hiv-avatar-project.com http://b...

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Behavioral Imaging, Big Data Talks To Be Featured At IS&T/SPIE Electronic Imaging

Next-generation imaging science and technology on the program for February event

Analyzing social interactions through imaging and making sense of the world's 3.5 trillion photographs are among featured topics at IS&T/SPIE Electronic Imaging 2015 in February in San Francisco. The event will draw researchers from academia, government, and industry from throughout the world for 21 conferences on topics in imaging systems, 3D display, image quality, optimization, and more.

The event will run 8-12 February at the Hilton San Francisco Union Square, sponsored by the Society for Imaging Science and Technology (IS&T) and SPIE, the international society for optics and photonics.

Electronic Imaging will showcase the latest developments in the field and provide multiple opportunities to network with leading researchers and entrepreneurs, said Symposium Chair Sheila Hamami of Northeastern University.

Choon-Woo Kim of Inha University is Symposium Co-chair, and Majid Rabbani of Eastman Kodak Co. is Short Course Chair.

In the week's first plenary talk, James Rehg (Georgia Institute of Technology) will present results from a multi-institution effort he leads that is working to develop the science and technology of behavior imaging- the capture and analysis of social and communicative behavior using multi-modal sensing. The work has applications in the study and treatment of developmental disorders such as autism.

Alexei (Alyosha) Efros (University of California, Berkeley) in the second plenary talk, with discuss the unique challegnes that make "big visual data" analysis difficult compared to other types of content. , Efros will present recent work that aims to address this challenge in the context of visual matching, image retrieval, visual data mining, and interactive visual data exploration.

A popular 3D Theatre session during the conference on Stereoscopic Displays and Applications is among the week's highlights. Content from around the world will be shown on a high-quality polarized 3D screen.

The event also offers a 16-course educational program on fundamental and current topics in digital imaging, image process and analysis, displays, and related topics; a two-day industry exhibition and employment marketplace; an interactive paper session; and a hands-on demonstration session featuring technology driving next-generation imaging hardware, software, display, and research capabilities.

Conference proceedings will be published online in the SPIE Digital Library after the event as manuscripts are approved, with CD publication following when all manuscripts are in. Presenters are also encouraged to submit work to the Journal of Electronic Imaging, co-published by SPIE and IS&T under Editor-in-Chief Gaurav Sharma of the University of Rochester.

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Behavioral Imaging, Big Data Talks To Be Featured At IS&T/SPIE Electronic Imaging

Zapped! U.S. Navy Deploys Laser Weapons

You know, I have one simple request. And that is to have sharks with frickin laser beams attached to their heads! Dr. Evil

Well, were not quite there yet, but the U.S. Navy released a video this week showing off thenot-so-secret laser weapons system its been testing for a while on ships in the Persian Gulf.

Dubbed LaWS, the technology is designed to help Navy vessels defend against asymmetrical warfare attacks by small, fast-moving threats like UAV drones or explosive-laden patrol boats.

U.S. Navy Game-Changer: Seawater Turned Into Fuel

The video, accompanied by a frankly goofy hard rock soundtrack, shows the LaWS system using directed-energy beams to essentially heat up and detonate oncoming threats. There are no visible laser bolts in the manner of the Death Star versus X-Wing fighters, say but you can see the weapon take out threats both at sea and in the air.

According to the accompanying report from the U.S. Naval Institute (USNI), the LaWS system installed on the transport ship USS Ponce successfully disabled incoming UAVs and rocket-propelled grenades and burned out the engines of approaching rigid hull inflatable boats.

Laser-Armed Humvees Could Shoot Down Drones

Theres also a quick sequence of images in the video showing a single crew member aiming the weapon with a device that looks a lot like your standard video game console controller. One of the benefits of the LaWS system, according to the Navy, is that its much simpler and less expensive than traditional explosive munitions.

Whats more, the LaWS system isnt just a test program anymore. The commander of the Ponce is now authorized to use the laser in defense of the vessel, according to the USNI report. And so it begins. The Navy hopes to deploy variations of the laser weapons across the entire fleet by 2020.

Credit: U.S. Navy

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Zapped! U.S. Navy Deploys Laser Weapons