Nanobiotix 2014 Review, 2015 Anticipated Milestones and Financial Calendar Nanobiotix Moved up to a New Level: Major …

PARIS--(BUSINESS WIRE)--Regulatory News:

NANOBIOTIX (Paris:NANO) (Euronext: NANO ISIN: FR0011341205), a late clinical-stage nanomedicine company pioneering novel approaches for the local treatment of cancer, provides its activities and achievements during 2014 and an overview of anticipated 2015 events including the financial calendar. The Company made major clinical and financial progress, including broadening of indications and strategic plans across Europe, Asia and the US.

Highlights

Laurent Levy, CEO of Nanobiotix said: 2014 has been a pivotal year for the Company, with significant progress in clinical development, where we jumped from an early clinical stage to late clinical stage. This has impacted our visibility and exposure from a financial and industrial point of view allowing us to accomplish two capital raises this year. We are now in a position to create value through the expansion of the indications and geographical area of development for the lead product, NBTXR3. As a result, 2015 is expected to be a year of further significant progress with intermediary clinical results, US corporate developments and launch of new indications; all building on the successes of 2014 and preparing for the final steps of CE marking by the end 2016 required before commercial launch.

Overview

Expansion of clinical development programme

The company is developing three different products that can be administered either by direct injection into the tumor (NBTXR3), intravenous injection (NBTX-IV) or topical application to fill tumor cavities just after tumor surgery (NBTX-TOPO).

NBTXR3 is the first product of the NanoXray portfolio to reach clinical development. The product comprises nanoparticles which can be injected directly into tumor. With the application of radiotherapy, these nanoparticles absorb X-rays which significantly enhances the radiation dose within the cancer cells without increasing the dose to the surrounding healthy tissues. Currently, NBTXR3 is classified as a medical device in Europe and a drug in the United States (US).

Soft tissue sarcoma (STS): green light to start registration trial

In June 2014 during ASCO, the Company presented positive Phase I clinical study results for NBTXR3, demonstrating feasibility and safety of intratumoral injection of the product followed by radiotherapy in patients with locally advanced STS. In addition to the feasibility and safety data presented, promising signs of efficacy have been demonstrated.

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Nanobiotix 2014 Review, 2015 Anticipated Milestones and Financial Calendar Nanobiotix Moved up to a New Level: Major ...

Movers & Shakers: WD-40 shares slip as results fall below Street view

SAN FRANCISCO (MarketWatch) Shares of WD-40 Co. slipped in the extended session Wednesday on an earnings miss.

WD-40 WDFC, -3.33% shares fell 5.2% to $81 on light volume after the companys fiscal first-quarter results fell short of Wall Street expectations.

Shares of NephroGenex Inc. NRX, +5.21% rose 19% to $10.99 on moderate volume after the clinical-stage drug company said late-stage studies on its diabetic nephropathy treatment Pyridorin would be able to support a marketing application in Europe. The company also disclosed that RHO Capital had taken an 11.9% stake in the company.

Bind Therapeutics Inc. BIND, +58.83% shares jumped 26% to $6.50 on moderate volume. The nanomedicine platform company said it expects one of its collaboration partners will file a drug application with the FDA by mid-2015 using their Accurin drug delivery particles.

Mistras Group Inc. MG, +12.53% shares rose 13% to $20.63 on light volume after the company reported fiscal second-quarter earnings of 33 cents a share on revenue of $206.9 million. Analysts had estimated 26 cents a share on revenue of $186.2 million.

Alexion Pharmaceuticals Inc. ALXN, -2.21% shares fell 4.8% to $179 in late trading after the company said a phase 2 clinical trial of eculizumab -- a drug to help prevent rejection of kidney transplants -- failed to meet its primary composite endpoint.

Insulet Corp. PODD, -8.16% shares fell 7.9% to $41 on moderate volume after the insulin pump company said it expects fourth-quarter revenue of $71 million to $73 million, down from a previous estimate of $76 million to $81 million, because of a delay in product shipments. Analysts had expected $79.6 million.

Zumiez Inc. ZUMZ, -0.65% shares rose 2.7% to $41.35 on light volume after the specialty retailer raised its guidance for the fourth quarter.

These were the stocks making notable moves during the regular session Wednesday:

Keurig Green Mountain Inc. GMCR, +2.30% signed a deal with Dr Pepper Snapple Group Inc. DPS, +1.67% to sell capsules that make its sodas in Keurigs planned cold-drink machine.

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Movers & Shakers: WD-40 shares slip as results fall below Street view

Brangelina: Secret Pope plans

Published January 07, 2015

May 8, 2014. Brad Pitt and Angelina Jolie arrive for a special Maleficent Costume Display at Kensington Palace in London.(Reuters)

The King and Queen of Hollywood are set to meet another titled leader the Pope, reports Us Weekly. The couple will reportedly visit the Vatican early this month for a VIP meet-and-greet with Pope Francis.

Pitt grew up Baptist but told the Hollywood Reporter in 2012, I dont have a great relationship with religion. I oscillate between agnosticism and atheism.

But a friend tells the magazine that the glamorous couple admire the Pope and like his message of tolerance and non-judgement. In 2013 talking about homosexuality the Pope famously said, If someone is gay and he searches for the Lord and has goodwill, who am I to judge?

According to the source the couples head of security has gone to Rome to iron out the details of the visit.

Meanwhile Jolie is recovering from a bout of chicken pox that kept her from promoting her movie, Unbroken. Pitt was last seen at the Palm Springs International Film Festival.

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Brangelina: Secret Pope plans

Angelina Jolie and Brad Pitt to visit Pope Francis?

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FRIENDS IN HIGH PLACES: Angelina Jolie and Brad Pitt have arranged to meet with Pope Francis at the Vatican.

First the Queen and now the Pope ... it seems that Brangelina are headed for the Vatican.

According to a report in US Weekly,Angelina Jolie and Brad Pitt have a scheduled "VIP meet-and-greet at the Vatican with Pope Francis" in early January.

Despite Pitt rejecting his Baptist upbringing, a source told the magazine the couple "like the Pope's message" and "admire" him.

In an interview with The Hollywood Reporter in 2012, Pitt, 51, said, "I grew up very religious, and I don't have a great relationship with religion."

"I oscillate between agnosticism and atheism," he said.

The actor also said he wouldn't get married until gay marriage is legalised for everyone.

"We made this declaration some time ago that we weren't going to do it untileveryone can. But I don't think we'll be able to hold out. It means so much to my kids, and they ask a lot. And it means something to me, too, to make that kind of commitment," he said.

Perhaps Pope Francis' stance on gay marriage has led Pitt to have a change of heart.

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Angelina Jolie and Brad Pitt to visit Pope Francis?

Brad Pitt, Angelina Jolie to Meet Pope Francis at the Vatican: Get the Details!

Hollywood meets the Holy See! Tinseltown royalty Brad Pitt and Angelina Jolie are taking a very special trip to Rome this month, not to eat pasta and tour the Colosseum, but to meet the Pope, an insider reveals exclusively in the new issue of Us Weekly.

PHOTOS: Brangelina's love story

The A-listers will fly to Italy in early January "for a VIP meet-and-greet at the Vatican with Pope Francis," the source says of the stars, who consider themselves nonreligious.

Pitt, 51, grew up Baptist but later distanced himself from his faith, telling The Hollywood Reporter in 2012, "I don't have a great relationship with religion. I oscillate between agnosticism and atheism."

PHOTOS: All of Angelina's Us Weekly covers

That said, a friend tells Us that both the actor and his wife "admire the Pope" and "like the Pope's message." (Pope Francis is thought to be more tolerant than his predecessors; speaking about homosexuality in 2013, he famously said, "If someone is gay and he searches for the Lord and has goodwill, who am I to judge?")

PHOTOS: Brad's sexy movie looks

The jet-setting stars have been busy in recent days with individual projects Pitt was at the Palm Springs International Film Festival on Jan. 3, while Jolie was spotted in Las Vegas but arrangements for their visit are under way.

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Brad Pitt, Angelina Jolie to Meet Pope Francis at the Vatican: Get the Details!

Angelina Jolie arrives in Italy to meet Pope Francis

Angelina Jolie has flown to Italy to meet Pope Francis.

The 'Maleficent' actress was spotted with her daughters Shiloh, eight, and Zahara, nine, at Ciampino International Airport in Rome today (07.01.15) amid speculation she and husband Brad Pitt are set to have "a VIP meet-and-greet at the Vatican with Pope Francis" this week.

The duo's head of security is said to have arrived in the city to begin preparations for their arrival a few days ago.

A source close to the couple, who consider themselves non-religious, told Us Weekly magazine that the 39-year-old beauty and the 51-year-old actor both "admire the Pope" and "like the Pope's message."

Pope Francis has been praised for being more tolerant than his predecessors. When asked about views on homosexuality last year, he said: "If someone is gay and he searches for the Lord and has goodwill, who am I to judge?"

'Fury' star Brad was raised a Baptist, but previously admitted he didn't "have a great relationship with religion."

He said: "I oscillate between agnosticism and atheism."

But Angelina recently revealed she is very spiritual.

She said: "I don't know if there's a name for that - religion or faith - just that there's something greater than all of us, and it's uniting and beautiful."

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Angelina Jolie arrives in Italy to meet Pope Francis

Are Angelina Jolie and Brad Pitt about to meet Pope Francis in Rome?

(CREDIT: REUTERS/PATRICK RIVIERE)

Angelina Jolie (L-R), cast member Miyavi, his wife Melody Ishihara and Brad Pitt attend the world premiere of Jolie's film ''Unbroken'' at the State Theatre in Sydney November 17, 2014.

Hollywood actress and producer Angelina Jolie arrived in Rome on Wednesday with daughters Zahara, 9, and Shiloh, 8, amid speculation that she will meet the Pope this week.

Sources say Jolie and husband Brad Pitt will meet Pope Francis in a "VIP meet-and-greet at the Vatican" while they are in town.

The paparazzi were on hand as the trio arrived at the Ciampino airport with their bodyguards this afternoon, and entered an awaiting black SUV. According to UsWeekly, Jolie's head of security flew out earlier to conduct a security check prior to the family's arrival.

It is unclear if Pitt is already in Rome or will arrive at a later date.

The 51-year-old leading man was raised in the Southern Baptist faith, but does not consider himself a Christian.

"I grew up very religious, and I don't have a great relationship with religion," he told TheHollywood Reporterin a 2012 interview. "I oscillate between agnosticism and atheism."

Jolie, 39, rarely discusses her faith in interviews, but appeared to lean towards atheism in 2000 when asked if there is a God.

"For some people," she told A.V. Club. "I hope so, for them. For the people who believe in it, I hope so. There doesn't need to be a God for me. There's something in people that's spiritual, that's godlike.

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Are Angelina Jolie and Brad Pitt about to meet Pope Francis in Rome?

Requirements of implementing next generation science standards

WASHINGTON -- A new report released today by the National Research Council offers guidance to district and school leaders and teachers on necessary steps for putting the Next Generation Science Standards (NGSS) into practice over the next decade and beyond. The committee that wrote the report drew on A Framework for K-12 Science Education: Practices, Crosscutting Concepts, and Core Ideas, a 2011 Research Council report that served as the foundation for the Next Generation Science Standards. These standards are informed by research findings that emphasize that science and engineering involve both knowing and doing; that developing rich, conceptual understanding is more productive for future learning than simply memorizing discrete facts; and learning experiences should be designed with coherent progressions over multiple years.

"The NGSS present a vision of science and engineering learning that brings these subjects alive for all students, emphasizing the satisfaction of pursuing compelling questions and the joy of discovery and invention," said Helen Quinn, committee chair and professor emerita of particle physics and astrophysics at the Stanford Linear Accelerator Center at Stanford University. "While 13 states and the District of Columbia have already adopted the NGSS, achieving this vision in all science classrooms will be a major undertaking and will require changes to many aspects of science education."

The committee's recommendations cover the major elements of the education system that should be considered when implementing the NGSS, including:

Along with an understanding of the vision described in the framework, the committee identified the following seven principles by which implementation of the NGSS should be guided:

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The study was sponsored by the National Science Foundation, College Board, and Burroughs-Wellcome Fund. The National Academy of Sciences, National Academy of Engineering, Institute of Medicine, and National Research Council make up the National Academies. They are private, independent nonprofit institutions that provide science, technology, and health policy advice under a congressional charter granted in 1863. The National Research Council is the principal operating arm of the National Academy of Sciences and the National Academy of Engineering. For more information, visit http://www.national-academies.org. A committee roster follows.

Contacts

Dana Korsen, Media Officer

Christina Anderson, Media Assistant Office of News and Public Information 202-334-2138 e-mail news@nas.edu

http://national-academies.org/newsroom

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George F. Will: History shows how human behavior changes along with climate

Human behavior did not cause this climate change. Instead, climate warming caused behavioral change (10 million mouths to feed became 30 million).

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WASHINGTON

We know, because they often say so, that those who think catastrophic global warming is probable and perhaps imminent are exemplary empiricists. They say those who disagree with them are "climate change deniers" disrespectful of science.

Actually, however, something about which everyone can agree is that of course the climate is changing it always is. And if climate Cassandras are as conscientious as they claim to be about weighing evidence, how do they accommodate historical evidence of enormously consequential episodes of climate change not produced by human activity? Before wagering vast wealth and curtailments of liberty on correcting the climate, two recent books should be considered.

In "The Third Horseman: Climate Change and the Great Famine of the 14th Century," William Rosen explains how Europe's "most widespread and destructive famine" was the result of "an almost incomprehensibly complicated mixture of climate, commerce, and conflict, four centuries in gestation." Early in that century, 10 percent of the population from the Atlantic to the Urals died, partly because of the effect of climate change on "the incredible amalgam of molecules that comprises a few inches of soil that produces the world's food."

In the Medieval Warm Period (MWP), from the end of the ninth century to the beginning of the 14th, the Northern Hemisphere was warmer than at any time in the last 8,000 years for reasons concerning which there is no consensus. Warming increased the amount of arable land there were vineyards in northern England leading, Rosen says, to Europe's "first sustained population increase since the fall of the Roman Empire." The need for land on which to grow cereals drove deforestation. The MWP population explosion gave rise to towns, textile manufacturing and new wealthy classes.

Then, near the end of the MWP, came the severe winters of 1309-1312, when polar bears could walk from Greenland to Iceland on pack ice. In 1315 there was rain for perhaps 155 consecutive days, washing away topsoil. Upwards of half the arable land in much of Europe was gone; cannibalism arrived as parents ate children. Corpses hanging from gallows were devoured.

Human behavior did not cause this climate change. Instead, climate warming caused behavioral change (10 million mouths to feed became 30 million). Then climate cooling caused social changes (rebelliousness and bellicosity) that amplified the consequences of climate, a pattern repeated four centuries later.

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George F. Will: History shows how human behavior changes along with climate

Brain imaging may help predict future behavior

Noninvasive brain scans, such as functional magnetic resonance imaging, have led to basic science discoveries about the human brain, but they've had only limited impacts on people's day-to-day lives. A review article published in the January 7 issue of the Cell Press journal Neuron, however, highlights a number of recent studies showing that brain imaging can help predict an individual's future learning, criminality, health-related behaviors, and response to drug or behavioral treatments. The technology may offer opportunities to personalize educational and clinical practices.

Dr. John Gabrieli of the Massachusetts Institute of Technology in Cambridge and his colleagues describe the predictive power of brain imaging across a variety of different future behaviors, including infants' later performance in reading, students' later performance in math, criminals' likelihood of becoming repeat offenders, adolescents' future drug and alcohol use, and addicts' likelihood of relapse.

"Presently, we often wait for failure, in school or in mental health, to prompt attempts to help, but by then a lot of harm has occurred," says Dr. Gabrieli. "If we can use neuroimaging to identify individuals at high risk for future failure, we may be able to help those individuals avoid such failure altogether."

The authors also point to the clear ethical and societal issues that are raised by studies attempting to predict individuals' behavior. "We will need to make sure that knowledge of future behavior is used to personalize educational and medical practices, and not be used to limit support for individuals at higher risk of failure," says Dr. Gabrieli. "For example, rather than simply identifying individuals to be more or less likely to succeed in a program of education, such information could be used to promote differentiated education for those less likely to succeed with the standard education program."

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The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.

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