Genetic engineering, also called genetic modification, is the direct manipulation of an organism's genome using biotechnology. It is therefore a set of technologies used to change the genetic makeup of cells, including the transfer of genes within and across species boundaries to produce improved or novel organisms. New DNA may be inserted in the host genome by first isolating and copying the genetic material of interest using molecular cloning methods to generate a DNA sequence, or by synthesizing the DNA, and then inserting this construct into the host organism. Genes may be removed, or "knocked out", using a nuclease. Gene targeting is a different technique that uses homologous recombination to change an endogenous gene, and can be used to delete a gene, remove exons, add a gene, or introduce point mutations.
An organism that is generated through genetic engineering is considered to be a genetically modified organism (GMO). The first GMOs were bacteria generated in 1973 and GM mice in 1974. Insulin-producing bacteria were commercialized in 1982 and genetically modified food has been sold since 1994. Glofish, the first GMO designed as a pet, was first sold in the United States December in 2003.
Genetic engineering techniques have been applied in numerous fields including research, agriculture, industrial biotechnology, and medicine. Enzymes used in laundry detergent and medicines such as insulin and human growth hormone are now manufactured in GM cells, experimental GM cell lines and GM animals such as mice or zebrafish are being used for research purposes, and genetically modified crops have been commercialized.
Process of inserting new genetic information into existing cells in order to modify a specific organism for the purpose of changing its characteristics.
Note: Adapted from ref.
Genetic engineering alters the genetic make-up of an organism using techniques that remove heritable material or that introduce DNA prepared outside the organism either directly into the host or into a cell that is then fused or hybridized with the host. This involves using recombinant nucleic acid (DNA or RNA) techniques to form new combinations of heritable genetic material followed by the incorporation of that material either indirectly through a vector system or directly through micro-injection, macro-injection and micro-encapsulation techniques.
Genetic engineering does not normally include traditional animal and plant breeding, in vitro fertilisation, induction of polyploidy, mutagenesis and cell fusion techniques that do not use recombinant nucleic acids or a genetically modified organism in the process. However the European Commission has also defined genetic engineering broadly as including selective breeding and other means of artificial selection.Cloning and stem cell research, although not considered genetic engineering, are closely related and genetic engineering can be used within them.Synthetic biology is an emerging discipline that takes genetic engineering a step further by introducing artificially synthesized material from raw materials into an organism.
If genetic material from another species is added to the host, the resulting organism is called transgenic. If genetic material from the same species or a species that can naturally breed with the host is used the resulting organism is called cisgenic. Genetic engineering can also be used to remove genetic material from the target organism, creating a gene knockout organism. In Europe genetic modification is synonymous with genetic engineering while within the United States of America it can also refer to conventional breeding methods. The Canadian regulatory system is based on whether a product has novel features regardless of method of origin. In other words, a product is regulated as genetically modified if it carries some trait not previously found in the species whether it was generated using traditional breeding methods (e.g., selective breeding, cell fusion, mutation breeding) or genetic engineering. Within the scientific community, the term genetic engineering is not commonly used; more specific terms such as transgenic are preferred.
Plants, animals or micro organisms that have changed through genetic engineering are termed genetically modified organisms or GMOs. Bacteria were the first organisms to be genetically modified. Plasmid DNA containing new genes can be inserted into the bacterial cell and the bacteria will then express those genes. These genes can code for medicines or enzymes that process food and other substrates. Plants have been modified for insect protection, herbicide resistance, virus resistance, enhanced nutrition, tolerance to environmental pressures and the production of edible vaccines. Most commercialised GMO's are insect resistant and/or herbicide tolerant crop plants. Genetically modified animals have been used for research, model animals and the production of agricultural or pharmaceutical products. They include animals with genes knocked out, increased susceptibility to disease, hormones for extra growth and the ability to express proteins in their milk.
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- Engineering Illusions Part I: Religion and Technology III - Medium - April 9th, 2021
- Genetic Engineering in Humans - Curing Diseases and ... - March 9th, 2020
- Human Genetic Engineering - AllAboutPopularIssues.org - March 9th, 2020
- Human Genetic Engineering Probe Ministries - March 9th, 2020
- Human Genetic Engineering Facts - August 14th, 2017
- The ethics of creating GMO humans | The Spokesman-Review - The Spokesman-Review - August 6th, 2017
- Human Genetic Engineering Cons - July 26th, 2017
- China unveils technology to create SUPER-HUMANS via hyper-muscular test-tube dogs - Express.co.uk - July 19th, 2017
- The Scopes Monkey Trial and global warming: Same playbook, different football - Baptist News Global - July 14th, 2017
- Science and Scientists on the Vineyard: Genes at play with CRISPR - Martha's Vineyard Times - June 17th, 2017
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- 'Knights of Sidonia' is the Pinnacle of Gritty Mecha Anime - Inverse - June 12th, 2017
- Technosplit: The bifurcation of humanity - Salon - June 5th, 2017
- Breakthrough Regenerative Therapeutics Company Establishes Scientific Advisory Board - PR Newswire (press release) - May 4th, 2017
- Ethical Implications of Human Genetic Engineering | SAGE - April 19th, 2017
- Human Genetic Engineering on the Doorstep - hgalert.org - April 15th, 2017
- The Threat of Human Genetic Engineering - hgalert.org - April 12th, 2017
- Gene Editing Could Make You Smarter - Futurism - Futurism - March 1st, 2017
- Immoral Uses of Biotechnology Even With Good Intentions Are Evil - National Catholic Register - February 7th, 2017
- Human-pig hybrids might be unsettling. But they could save lives. - Washington Post - February 6th, 2017
- 5 Key Pros and Cons of Human Genetic Engineering | NLCATP.org - November 21st, 2016
- Gene therapy - Wikipedia - October 25th, 2016
- Human Genetic Engineering: A Guide for Activists, Skeptics ... - September 20th, 2016
- Human Genetic Engineering - The Future of Human Evolution - March 25th, 2016
- Human Genetic Engineering : History - December 22nd, 2015
- 00.03.07: Human Cloning, Genetic Engineering and Privacy - October 16th, 2015
- Online Debate: Human genetic engineering is a good thing ... - October 16th, 2015
- Bioethics Of Human Genetic Engineering - Documentary Video ... - September 30th, 2015
- Pros and Cons of Genetic Engineering in Humans - Part 1 - August 29th, 2015
- Genetic Engineering - humans, body, used, process, plants ... - August 27th, 2015
- Genetic Engineering In Humans - August 27th, 2015
- Human Nature on Collision Course with Genetic Engineering ... - August 27th, 2015
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- Human Genetics Alert - Human Genetic Engineering resources - August 19th, 2015
- Benefits of Human Genetic Engineering - Popular Issues - August 4th, 2015
- Human Genetics - July 31st, 2015
- Human Genetic Engineering Pros And Cons - July 31st, 2015
- Gene therapy - Wikipedia, the free encyclopedia - July 28th, 2015
- Human Genetic Engineering - Popular Issues - July 28th, 2015
- Human Genetics Alert - The Threat of Human Genetic Engineering - July 28th, 2015
- Human Genetic Engineering - Popular Issues ... - February 16th, 2015
- Human Genetic Engineering - Buzzle - February 12th, 2015
- Pros and Cons of Genetic Engineering in Humans - February 12th, 2015
- Human Genetic Engineering History - February 12th, 2015
- Benefits of Human Genetic Engineering - Popular Issues ... - February 12th, 2015