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Category Archives: Cf

Protein promotes the respiratory complications of Cystic Fibrosis – Drug Target Review

Posted: July 15, 2020 at 9:48 pm

Researchers reveal the Vav3 protein is responsible for the formation of bacterial docking stations in the airway cells which promote the recurrent lung infections seen in Cystic Fibrosis patients.

Cystic fibrosis (CF) is one of the most common genetic disorders in Switzerland, it does not have a cure and requires life-long management throughout patients shortened lifespans. This reduced life expectancy is particularly attributed to recurrent, life-threatening respiratory infections, so researchers set out to establish why CF patients are so prone to these lung infections.

The team Scientists from the University of Geneva (UNIGE), Switzerland, discovered in their study that a protein called Vav3 promotes these infections by creating what they named a bacterial docking station on surface of the airways. The scientists also demonstrated that inhibiting Vav3 could prevent these recurrent infections and suggest this could be transferred into therapeutic prospects to limit respiratory complications in patients with CF.

CF, thought to affect more than 700,000 people worldwide, is caused by a mutation in a gene for a protein involved in the secretion of mucus. The result is an abnormally thick (hyperviscous) mucus that can cause severe respiratory and digestive problems, such as airway obstructions.

Aside from its role in airway obstruction, accumulations of the hyperviscous mucus also appear to play a role in promoting persistent lung infections, primarily caused by the bacteria Pseudomonas aeruginosa. These bacteria are known for being highly resistant to antibiotics, so understanding how it anchors to the cells of the airways is highly desirable.

Marc Chanson, Professor at the Department of Cell Physiology and Metabolism of the Faculty of Medicine of the UNIGE, explained: While it is known that mucus viscosity plays a role in trapping bacteria, the reason why they anchor so easily to airways was unknown. Anchoring of Pseudomonas aeruginosa to airways cells is the starting point for these often fatal infections. Understanding this process could help preventing their occurrence.

The protein Vav3 (in green) creates bacterial docking stations on the surface (in red) of respiratory cells (nuclei in blue) that facilitate airways infection in patients with cystic fibrosis [Credit: UNIGE, laboratoire Chanson].

In their paper, the researchers compared airway cells from people with healthy cells and those affected by CF. The whole project began when we found that the protein Vav3, which had not been shown to be involved in this disease until now, was over-expressed in sick cells, commented Mehdi Badaoui, researcher in Professor Chansons team and first author of this work.

After numerous in vitro analyses, the team discovered that in the CF cells Vav3 interacts with two other proteins, fibronectin and integrin b1, creating a complex on the cell surface that acts as a bacterial docking station, promoting Pseudomonas aeruginosa infections. This is the first time that a mechanism creating a favourable microenvironment for a bacterium before it even arrives has been observed, said Chanson. This might explain the high number of chronic lung infections in people with cystic fibrosis.

The team experimented further, inhibiting Vav3 expression in CF cells enabled them to prevent the expression of the two other proteins that make up the docking station. And, indeed, the absence of this structure limits the adhesion of Pseudomonas aeruginosa, added Badaoui.

Although the exact link between Vav3 and the genetic defect that causes CF has yet to be determined, the researchers concluded that their discovery is a promising therapeutic target for limiting respiratory complications.

The paper was published inCell Reports.

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Cystic Fibrosis: The grandfather and grandson who must remain 2m apart – BBC News

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Social distancing has become the new normal during the pandemic.

Millions across the UK have also had to "shield" due to their high risk of needing hospital treatment if they catch coronavirus.

An end to some restrictions is in sight - shielding is due to be paused at the end of July in Northern Ireland while social distancing has been reduced to 1m (3ft) with restrictions.

But Dr Ian Banks and his three-year-old grandson Lorcn Maguire, both from County Down, will not benefit from these changes.

They have always lived 2m apart.

Dr Banks has not held Lorcn since his grandson was diagnosed with cystic fibrosis (CF) - a genetic condition that can cause fatal lung damage.

He last touched him when his daughter, Jen Banks, visited his home to tell him about the diagnosis following a heel-prick test given to all newborn babies in the UK.

In a cruel twist of fate, the former A&E doctor has a long-term lung infection that could be deadly to his grandson.

"Ever since then, I have never come closer to him than 2m or 3m, and always downwind and never in the same room," he said.

Dr Banks said he had a good medical understanding of the need to stay 2m apart, not only with Lorcn, but also with his parents, due to the risk of cross-infection.

But he said it was heartbreaking to do so.

"Even with all that medical training, your relationship with your own child is very different," he said.

"We have been in social isolation for three years when it comes to our family.

"I can't even hug my own daughter, I haven't touched Jen since Lorcn was born.

"It's a huge strain on your relationship, particularly when you are used to touching people as humans are."

Despite the challenges, Dr Banks said Lorcn looks healthy, is a "wonderful little fella" and a credit to his parents.

"Even the tiniest things we take for granted can be lethal when it comes to CF, so you are constantly worrying over whether you are going to give this child an infection," he said.

"You never get used to it, when the virus crisis declines we will still be where we are."

Jen said the need to be apart from family was "one of the worst things" about her child's diagnosis.

She said it went against instinct not to hug her dad out of fear that it could hurt her son and that it "never felt normal" despite the passage of time.

"From the start of them being together, they have always been 2m apart," she said.

It has meant many difficult decisions around whether Jen's father or her son attend birthdays, weddings and funerals, while extended family Christmases are virtually impossible, she added.

"Family is the most important thing in most people's lives so not to be as close to them as you want to be, not to be able to share a meal in the same house, not to be able to come and visit with you, it's not ok," she said.

Jen said she vividly recalled the last touch between her father and son.

"I put Lorcn into his arms before I told him [the diagnosis] because I wanted him to feel him - love is so tactile," she said.

"I said: 'We've some bad news. Lorcn has been diagnosed with CF'.

"My dad handed him straight back into my arms. He knew immediately he could be a risk to Lorcn.

"He has never held him again, very rarely been within 6ft, never held his hand, lifted him on his shoulders, any normal things a grandfather would do with his grandson."

Dr Banks said it was an "absolutely heartbreaking" moment that had repercussions throughout their family.

Jen said there were "dark days" during which they campaigned with the CF community for access to the best treatments.

"Since he was born we have been fighting - fighting for access to the right drugs, fighting infections we can't clear, it's been awful," she said.

The situation improved when Lorcn was prescribed the life-extending drug Orkambi after it was made available in Northern Ireland at the end of 2019.

Lorcn has thrived on Orkambi but campaigning continued for Kaftrio, another groundbreaking drug that tackles the underlying causes of the disease by helping the lungs work effectively.

Health Minister Robin Swann said last week that a deal had been struck with the makers of Kaftrio, which will also become available on the NHS.

The Cystic Fibrosis Trust has described the drug as life saving and Mr Swann said the importance of the deal to affected families "cannot be emphasised enough".

Jen said the news was a "complete dream".

Although there are no clinical guidelines as yet, she hopes Lorcn will start Kaftrio when he is six - subject to the age limit being reduced from 12 - finally enjoying a more normal relationship with her father due to a reduced risk of cross-infection.

"Obviously we still need to social distance until then, but there is light at the end of the tunnel," she said.

She said she was "incredibly grateful to the NHS" and Lorcn's CF team who were "the best in the world" and added that campaigning for those who would not benefit from Kaftrio will continue.

Dr Banks described Kaftrio as a "game-changer" that should enable Lorcn's body to work normally.

"It is very hard, even with a medical background, to maintain what we are doing," he said.

"At the age of 70 I think I am allowed to be optimistic, I think the future for these children is so much brighter.

"I am looking forward to his sixth birthday because that is when he is going to start [on Kaftrio] hopefully, and that will be the first time since he was born I will be able to give him a hug."

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Calithera Biosciences Initiates Phase 1b Trial of Arginase Inhibitor CB-280 for the Treatment of Cystic Fibrosis – GlobeNewswire

Posted: at 9:48 pm

SOUTH SAN FRANCISCO, July 13, 2020 (GLOBE NEWSWIRE) -- Calithera Biosciences, Inc. (Nasdaq: CALA), a clinical stage biotechnology company focused on discovering and developing novel small molecule drugs for the treatment of cancer and other life-threatening diseases, today announced that it has dosed the first patients in its Phase 1b clinical trial of the arginase inhibitor CB-280 in adult patients with cystic fibrosis (CF) and chronic airway infection. The study will evaluate the safety and optimal dose range of CB-280 when added onto existing therapies for CF patients, including CFTR modulators.

We remain committed to advancing our arginase inhibitor clinical development program to fully explore the potential of this new class of therapeutics in a variety of conditions, said Susan Molineaux, PhD, president and chief executive officer of Calithera. Based on preclinical data and the unique pathology of this disease, we believe that CB-280s mechanism of action represents an opportunity to further improve upon the current standard-of-care for CF patients, for whom there remains great unmet need despite recent therapeutic advancements.

Research in CF patients has demonstrated that increased arginase activity correlates directly with worsened lung function, and reduced expiratory nitric oxide (NO) levels. Pre-clinical studies conducted by Calithera and collaborators have shown that arginase inhibition increases systemic arginine levels, decreases airway bacterial colonies, and improves lung function in CF mouse models of infection. Inhibiting arginase may reduce infection and improve lung function in people with CF. Chronic poly-microbial infection remains a major area of unmet need in CF.

The Phase 1b randomized, double blind, placebo-controlled, dose escalation trial will evaluate multiple ascending doses of CB-280 compared to placebo in 32 adult CF patients to determine a safe dose range for CB-280, dosed orally twice daily for 14 days. The study follows the completion of a Phase 1 trial that evaluated the safety, tolerability and pharmacokinetic profile of CB-280 in healthy volunteers, which was conducted under a United States Food and Drug Administration Investigational New Drug (IND) application.

In October 2017, Calithera entered into a global collaboration agreement with Incyte, focused on research, development and commercialization of a first-in-class arginase inhibitor in hematology and oncology. As part of this agreement, Calithera retained the rights to develop additional arginase inhibitors in specific non-oncology indications, including CF. The molecule being evaluated in these clinical trials, CB-280, is wholly owned by Calithera.

About Calithera

Calithera Biosciences is a clinical-stage biopharmaceutical company pioneering the discovery and development of targeted therapies that disrupt cellular metabolic pathways to preferentially block tumor cells and enhance immune-cell activity. Driven by a commitment to rigorous science and a passion for improving the lives of people impacted by cancer and other life-threatening diseases, Calithera is advancing a pipeline of first-in-clinic, oral therapeutics to meaningfully expand treatment options available to patients. Calithera is headquartered in South San Francisco, California. For more information about Calithera, please visit http://www.calithera.com.

Forward Looking Statements

Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as "may," "will," "expect," "anticipate," "estimate," "intend," "poised" and similar expressions (as well as other words or expressions referencing future events, conditions, or circumstances) are intended to identify forward-looking statements. These statements include those related to the safety, tolerability and efficacy of the arginase inhibitor CB-280 in adult patients with cystic fibrosis, the overall advancement of CB-280 in the Phase 1b clinical trial , the unmet need in the treatment of patients despite recent therapeutic advancements, Calitheras global collaboration with Incyte, and Calitheras plans to continue development of CB-280. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. The product candidates that Calithera develops may not progress through clinical development or receive required regulatory approvals within expected timelines or at all. In addition, clinical trials may not confirm any safety, potency or other product characteristics described or assumed in this press release. Such product candidates may not be beneficial to patients or successfully commercialized. The failure to meet expectations with respect to any of the foregoing matters may have a negative effect on Calithera's stock price. Additional information concerning these and other risk factors affecting Calithera's business can be found in Calithera's most recent Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission, and other periodic filings with the Securities and Exchange Commission at http://www.sec.gov. These forward-looking statements are not guarantees of future performance and speak only as of the date hereof, and, except as required by law, Calithera disclaims any obligation to update these forward-looking statements to reflect future events or circumstances.

SOURCE:Calithera Biosciences, Inc.

CONTACTS:

Investor RelationsJennifer McNealeyCalitherair@Calithera.com650-870-1071

MediaMichele ParisiSam Brown, Inc.micheleparisi@sambrown.com925-864-5028

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LETTER: Mother of local CF Warrior Madi Vanstone requesting help from the community in fight for access to orphan drugs – BradfordToday

Posted: at 9:48 pm

A letter from local resident Beth Vanstone, the mother of Cystic Fibrosispatient and warrior, Madi Vanstone:

When Madi was diagnosed with Cystic Fibrosis at eightmonths old it felt like our world had just crumbled around us.

Gone were out thoughts of raising our two little girls and looking forward to what ever lay ahead of them. Careers, families travel, growing old and living happy were shadowed by keeping Madi alive . Cystic Fibrosis stole those dreams from us and replaced them with countless hospital admissions, physio multiple times a day, bags full of medications and a very scary and tumultuous future.

As parents will do, we took the challenge put to us and did everything we could to provide Madi with the best life we could. We made fabulous memories and packed in lots of fun each day when she was well enough. While we focused on raising our girls we also jumped into fundraising for CF and research hoping against hope that one day there would be a cure and a future for our little girl.

Well after 11 years, as Madi's health was declining rapidly, we were given hope in the form of two little blue pills. Kalydeco the first gene modulator was here and it was going to save our daughter. Well, it wasn't quite as easy as that, there was our very public two year battle for drug funding, but that's another story. Fast forward sevenyears and Madi's life and our lives have been transformed. Two pills a day have taken Madi who was slowly drowning daily in her Cystic Fibrosis, to a healthy and happy young woman who is looking forward to a beautiful and bright future. These two little blue pills taken twice a day correct the defect in the gene that causes Cystic Fibrosis. Tested today while on her medication she tests NEGATIVE for the disease.

Kalydeco was the first of a new generation of gene modulators and sadly only effective in a very small percentage of patients. The fourth generation and by far the best of the modulators is here, Trikafta is saving lives around the world every day. Patients at the end stage of their disease are coming out of their hospital beds and living again, going back to work, looking forward to exciting futures they thought they would never see! Sadly Canada has made some very deadly changes to regulations that pharmaceutical companies must comply with. These changes are literally killing patients and they prevent lifesaving drugs from being submitted to Canada.

CF families are begging for Canadians to stand with them as they respond to these changes, so they will not have to watch their children die as the drug that will save them sits outside our borders. We have made a VERY simple form for you to complete and stand with us to let government know Canadians deserve better. I urge you to please take the two minutes to complete and urge your friends and family to complete as well. We are hoping to get 4,400 submissions, one for each CF patient in Canada. Letters for Lives will save lives.

Please consider writing a letter to thePatented Medicine Price Review Board, using the following template here.

Thank you,

Beth Vanstone, Beeton

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Home on the Range: CF Ranch Along the Red River – D Magazine

Posted: at 9:48 pm

When the current owners of CF Ranch were looking to buy land to raise cattle, a powerful underground irrigation system sealed the deal on a northeast Texas ranch with great bones but in need of work. During the past three years, Parker Flannery has used a heavy rotational grazing technique he picked up ranching for nearly a decade in Australia to transform an estimated 1,600 to 1,700 grazing acres into lush terrain thats not only beneficial to cows but also sustainability.

Icon Global just listed his property for a cool $6.495 million.

About half an hour from charming Paris, Texas, the 2,105-acre CF Ranch offers miles of pristine Red River frontage with sandy beaches. The self-sustaining ranch is ideal for both beginners and professional ranchersand with two homes, a turnkey opportunity for a city dweller looking for a family getaway within 1.5 hours of Dallas.

Amenities include three spring-fed private lakes, each which are set within descending elevations, ensuring free flow and year-round enjoyment of bass fishing. Duck, hogs, and deer roam the ranch for prime hunting. And ranch facilities include pens, laneways, fencing, barns, a roping arena, shops, and hay barns.

Conventionally, 2,000-acre ranches have four pastures. At CF Ranch, more than 800 cows rotate through 15 different Bermuda-grass pastures, which the animals love because it means better food.

Once you rotate them enough, theyre broke and easy to manage, Flannery says. By putting them in a small area, we can kind of force them to that and not just the really good stuff, but they have to eat some of the junk too. And that way over time, by eating everything, it controls the junk and the good stuff. And the good stuff naturally will take over.

Rotational grazing is designed to improve soil health, grass quality, nutrient availability, and water-holding capacity. Additionally, it has eliminated the use of herbicide on the property, says Flannery, who also breeds polo-prospect horses at the ranch.

The ranch is crowned with woodsthe primary purpose for them is for fighting erosion, but the cows benefit from it too. Many ranchers free their cows in open pastures, but the key, Flannery says, is to provide shaded areas in each field. It makes the cows feel better, which makes the production better, and its more profitable for the farm.

A highlight of the property is 10 miles of underground pipe that flows on-demand to pivots and stock water troughs throughout, complementing a series of wells and other natural creeks ponds and water throughout the ranchinsulating it from drought. In Texas, theyre really rare, Flannery says. Floods come and go in three days but droughts can last years.

The soil and the water, he adds, is what makes the land rare. You wont get that anywhere else. Its just unreal.

Theres a huge disconnect between the city and the land, and theres not really a reason for it, Flannery says. People just seem sort of intimidated about getting into agriculture, but we need fresh blood, and its gotta happen.

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Braves’ CF Acuna has even bigger role in shortened 2020 season – Sumter Item

Posted: at 9:48 pm

By CHARLES ODUM The Associated Press

ATLANTA - Ronald Acuna Jr. isn't letting the coronavirus pandemic silence his love of baseball.

The empty seats at the Atlanta Braves' newly renamed Truist Park have left Acuna with more space to yell encouragement, sing and joke during workouts. Sometimes he teases or encourages his buddy, second baseman Ozzie Albies.

Acuna's constant chatter means there will be cheering at Braves games, even without the fans.

"You can hear his voice," Albies said. "It's so clear. ... He's always singing, always loud screaming. He enjoys the game."

Acuna, only 22, is an important lead voice for the Braves in the shortened 60-game season. Outfielder Nick Markakis has opted out and first baseman Freddie Freeman has been absent following a positive test for the coronavirus, taking away two of the team's leaders.

The Braves don't know when Freeman, the four-time All-Star, will return to the team. It seems increasingly unlikely he'll be ready for the July 24 opener at the New York Mets.

Freeman set career highs with 38 home runs and 121 RBIs last season as Atlanta won its second straight NL East title before falling to St. Louis in the playoffs.

Markakis, 36, made his decision to skip the season after talking on the telephone with Freeman and realizing Freeman was struggling with symptoms, including a fever. Another veteran, right-hander Felix Hernandez, the former Cy Young winner with Seattle, also opted out.

Acuna, Albies and free-agent addition Marcell Ozuna must lead the lineup while Freeman recovers.

Acuna is regarded as one of the top outfielders in the game after he hit .280 with 41 homers and 37 stolen bases in 2019, just missing a rare 40-40 season.

"It's obviously going to be hard not to have Nick around and we don't know what Freddie's status is going to be or how much he's going to be around," Acuna said through a translator. "We just have to keep moving on."

NEW LOOK

The Braves hope Ozuna can return to his peak form of 2017 with Miami, when he hit .312 with 37 homers and 124 RBIs. Ozuna couldn't match that production the last two years with St. Louis.

Ozuna, 29, could split his time between left field and designated hitter. He's expected to hit cleanup. Ozuna's production is crucial to the team's ability to replace Josh Donaldson, who signed with Minnesota.

The other key newcomers, set-up reliever Will Smith and left-handed starter Cole Hamels, may not be ready for the start of the season. Hamels, slowed by a sore left shoulder in spring training, was unable to throw a scheduled side session last week because of triceps tendinitis.

Smith was one of four players to test positive for the coronavirus at the start of summer camp. The others were Freeman, right-hander Touki Toussaint and infielder Pete Kozma. When he returns, Smith could push Mark Melancon for the closer's role.

ROOKIES TO WATCH

If Ozuna is the designated hitter, the outfield could include Acuna, Ender Inciarte and Adam Duvall. Rookies Cristian Pache and Drew Waters could be needed for depth.

Hamels' arm issues and the decision by Hernandez to opt out creates opportunities for such rookies as right-hander Kyle Wright, who could open the season in the rotation.

CORNER COMBO

Austin Riley opened spring in a competition with Johan Camargo to replace Josh Donaldson at third base. Manager Brian Snitker said he's confident Riley, who hit 18 homers as a rookie in 2019, could make a smooth transition if needed at first base while Freeman recovers.

Duvall also can play first base. Other options include Yonder Alonso and Peter O'Brien.

DUVALL'S DETERMINATION

Duvall, who has Type 1 diabetes, is a high-risk candidate for COVID-19. He said he made the decision to play after doing research and talking with his doctors.

Duvall said he needs his teammates to take proper precautions.

"It's a collective thing. Everybody has got to buy in," he said. "It's a pretty tight-knit group here. We've all got each other's back and we're all looking out for each other."

WASHINGTON'S TOE-TAP

Players can't hug or give high-fives, so third-base coach Ron Washington devised a toe-tap with players as a new way to celebrate during the pandemic.

"I just stuck my foot out," Washington said. "Next thing I know we started doing it."

Washington, 68, is at high risk for the virus. He remained with the team even after first-base coach Eric Young Sr. opted out.

To help his health, Washington said he stopped smoking on March 13, when MLB cut off spring training due to the pandemic.

"I trust Major League Baseball and the protocols they have in and I also trust me," he said.

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Cystic fibrosis drug tested to fight inflammation in COVID-19 – University College London Hospitals

Posted: at 9:48 pm

The COVASE trial has been funded by LifeArc, a medical research charity, and will be run in partnership with UCL and the Francis Crick Institute. Up to 40patients are expected to be recruited.

During a viral infection, a group of white blood cells called neutrophils release neutrophil extracellular traps (NETs) which are extra-cellular meshes whose primary role is to trap and kill bacteria. Researchers believe the immune system in COVID-19 patients is over-active and an abundance of NETs could be causing excess inflammation (hyperinflammation) and contributing to the onset of pneumonia and severe damage to the lungs.

In the trial, select hospital patients will be given Dornase alfa twice a day for seven days and researchers will examine the drugs effect on inflammation and survival. Historic controls will be derived from an existing database of 120 subjects with COVID-19 who have been admitted to UCLH since the beginning of the outbreak.

Chief Clinical Investigator, UCLH consultant Professor Joanna Porter, said: Hyperinflammation is an overreaction of the bodys immune system, which can cause serious breathing problems and has proven to be one of the most fatal conditions in those with severe COVID-19.

Dornase alfa has an excellent safety profile and has been used for many decades to help break down mucus secretion in the lungs of patients with cystic fibrosis.

Similar mucus secretions, along with cellular debris from NETs, have been seen in patients with COVID-19, so we are hopeful this drug can have a similar positive effect reducing inflammation and enabling patients to be discharged from hospital earlier than they would have been without the treatment.

This trial is based on research by Dr Venizelos Papayannopoulos at the Crick. His lab has already identified specific damage-associated molecular patterns (DAMPs) in NETs that are responsible for excess inflammation during infection. The trial aims at clearing these DAMPs using Dornase. Therefore, the Crick lab will be monitoring the effect of the treatment on the presence of these DAMPs and the impact on inflammation in patients on the trial.

Dr Papayannopoulos said: Weve spent years studying how the immune system interacts with microbes to protect against infection but also, what happens when these responses are deregulate to promote disease.

The challenge at hand is to use this information in order to tackle excess inflammation in the lungs of patients with COVID-19. We hope to reduce the amount of time people spend in hospital and the number of patients who require intensive care.

Dornase alfa has been approved since 1994 for the treatment of cystic fibrosis (CF), an inherited condition that causes mucus to build up in the lungs. The drug is delivered directly to the lungs as patients breathe in a mist created by a nebuliser. In CF patients it has been shown to reduce NETs and inflammation, reduce the risk of developing a respiratory tract infection, and improve pulmonary function.

The drug can be self-administered at home and so if shown to be effective in hospital, could also benefit people with COVID-19 who have mild disease and are self-isolating, or those who have been discharged from hospital to continue their recovery at home.

This study is being supported by a grant from the medical research charity LifeArc, as part of its activities to address the need for new therapies for Covid-19. LifeArc has made 10m available to repurpose existing medicines or those in the late stage of development as this approach offers one of the fastest routes to develop new treatments that could tackle the virus and its impact.

The Dornase alfa will be administered using the PARI eFlowRapid electronic nebuliser, kindly donated by Pari.

Support for the COVASE study design and protocol was provided by the statistical analysis specialists, Exploristics, and by drug discovery and development consultancy, Target 2 Treatment.

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Other Sports: BRAVE CF partners with WIN Sports – Gulf Digital News

Posted: at 9:48 pm

BRAVE Combat Federation, the fastest-growing mixed martial arts organisation in the world, has struck a broadcasting deal with WIN Sports, one of the leading sports networks in Colombia.

The partnership aims to expand BRAVE CF Latin America, where it is already seen as one of the giants of the sporting world.

The organisation, founded by Supreme Council for Youth and Sports first deputy chairman and Bahrain Olympic Committee president Shaikh Khalid bin Hamad Al Khalifa, has constantly invested in Latin America, with four shows in Brazil and two in Colombia. After BRAVE CF 26 beat UFC Abu Dhabi with Khabib Nurmagomedov last year in the Colombian households ratings, WIN Sports and BRAVE CF made a long-term deal official.

According to the deal, WIN Sports will broadcast BRAVE CF fights every Saturday in their prime time, proving that the Bahraini organisation has truly become the only global MMA promotion.

Among the Colombian stars expected to feature are Eduardo Mora and Dumar Roa. The latter shocked the MMA world last November by knocking out former BRAVE CF lightweight world champion Abdul Kareem Al Selwady at BRAVE CF 29 in Bahrain.

I cant wait for my people in Colombia to witness BRAVE CF events. They will fall in love with the sport. I want to represent my country at the highest level and thats what BRAVE CF provided me, said Roa.

Roas victory has been seen as the beginning of a revolution for MMA in Colombia, with BRAVE CF and its partner Latin Fighter Championship at the head of transforming the sporting scene in yet another region.

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Other Sports: BRAVE CF and Fight Globe announce content tie-up – Gulf Digital News

Posted: at 9:48 pm

Top mixed martial arts promoter BRAVE Combat Federation and Fight Globe have announced a new partnership for the international content distribution of BRAVE CFs MMA events.

The Bahrain-based MMA promotion is considered one of the fastest-growing sports promotions in the world and has hosted 34 events globally in a little over three years.

We are thrilled to represent BRAVE CF and look forward to working with their team, said Fight Globe CEO Sabine Kesseler.

BRAVE CF is one of the reasons why we are in the MMA business. It guarantees top-notch fight and superb production. It is very impressive what they have accomplished in such a short time.

BRAVE CF president Mohammed Shahid added, As the only truly global MMA promotion, we are pleased to add the largest distributor of fight content worldwide to our BRAVE family. We are confident that Fight Globe will accelerate our effort of introducing fans around the world to our vision and content as the fastest growing MMA promotion in the world.

Earlier this year BRAVE CF had postponed BRAVE CF 35 to 37 due to the Covid-19 pandemic. However, Bahrain based MMA pioneer Mohammed The Hawk Shahid made the much-anticipated statement that it will resume its roster announcing several more events for this year starting with BRAVE CF 35 taking place on Monday in Romania.

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Complex Fertilizers 2020: Record Overwhelming Hike in Revenues by 2027 | CF Industries Holdings Inc. (US),Yara International ASA (Norway) – Daily…

Posted: at 9:48 pm

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Complex Fertilizers Market and Competitive Analysis:

Know your current market situation! Not just new products but existing products are given the ever-changing market dynamics. The study allows market professionals to stay tuned with the latest trends and segment performance where they can see a rapid market share drop. Identify who you really compete within the marketplace, with Market Share Analysis correlate your market position, % Market Share, and Segmented Revenue.

Some Key Players from complete research coverage: CF Industries Holdings Inc. (US),Yara International ASA (Norway),The Mosaic Company (US),EuroChem Group AG (Switzerland),Potash Corporation of Saskatchewan (Canada),PhosAgro (Russia),Agrium Inc. (Canada),Israel Chemicals Limited (Israel),Sociedad Qumica y Minera de Chile (Chile),Haifa Chemicals Ltd., (Israel),Helena Chemical Company (US),Zuari Agro Chemicals Ltd (India)(*Note: Other Players Can be Added per Request)

How Study Have Considered the Impact of COVID-19 / Economic Slowdown of 2020?

Analyst at Worldwide Market Reports has conducted a special survey and has connected with opinion leaders and industry experts from the various regions to minutely understand the impact on growth as well as local reforms to fight the situation. A special chapter in the study presents Impact Analysis of COVID-19 on Global Complex Fertilizers Market along with tables and graphs related to various countries and segments showcasing impact on growth trends.

Regions Mentioned in this Complex Fertilizers Market Report:

The Complex Fertilizers Market and its dynamics are analyzed using admissible tools and techniques. A qualitative study forms a sizeable portion of the Complex Fertilizers research efforts, and with estimated changes on the horizon, it is projected to witness significant revenue growth over the next five to eight years. It is important that major players in the target market derive key insights and make or apply the ideal strategies and investments to capitalize on emerging opportunities in the near future. The report is helpful to the companies both new and established to analyze white spaces and opportunities for growth in the Complex Fertilizers market.

Complex Fertilizers Market research report delivers a close watch on leading competitors with strategic analysis, micro and macro market trend and scenarios, pricing analysis, and a holistic overview of the market situations in the forecast period. It is a professional and a detailed report focusing on primary and secondary drivers, market share, leading segments, and geographical analysis. Further, key players, major collaborations, mergers and acquisitions along with trending innovation and business policies are reviewed in the report.

Influence of the Complex Fertilizers market report:

-Comprehensive assessment of all opportunities and risks in the market.-Complex Fertilizers market recent innovations and major events.-Detailed study of business strategies for the growth of the market-leading players.-Conclusive study about the growth plot of the Complex Fertilizers market for forthcoming years.-In-depth understanding of market-particular drivers, constraints, and major micro markets.-Favorable impression inside vital technological and market latest trends striking the market.

Definitively, this report will give you an unmistakable perspective on every single reality of the market without a need to allude to some other research report or an information source. Our report will give all of you the realities about the past, present, and eventual fate of the concerned Market.

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Read more from the original source:

Complex Fertilizers 2020: Record Overwhelming Hike in Revenues by 2027 | CF Industries Holdings Inc. (US),Yara International ASA (Norway) - Daily...

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