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Category Archives: DNA

DNA from discarded cigarette leads to arrest in 3-year-old case – Butler Eagle

Posted: May 14, 2020 at 5:22 pm

A discarded cigarette butt came back to burn a suspected thief.

More than three years after the alleged crime, Brandon S. Ward-Smith, 31, of Butler is facing criminal charges.

State police last month charged Ward-Smith, a felon, with breaking into four vehicles in Summit Township on Feb. 5 and 6, 2017.

During their initial investigation, police said, they took reports of four thefts from vehicles at two homes each on Kemar Drive and Saxonburg Road. The four homes are less than one mile apart and just a minute's travel time by vehicle.

The proximity of the homes and because all of the thefts occurred within one day of each other led police to suspect the same person was involved.

The loot taken from the vehicles included jewelry, a gift card, a folding knife and currency valued collectively at a little more than $400.

Investigators at one home, police said, found a fresh cigarette in the driveway next to the vehicle that had been ransacked. The potential evidence was collected and later sent to the state police crime lab in Westmoreland County.

On March 16, 2018, police got good news: there was a hit on the DNA taken from the cigarette.

Specifically, investigators said, the Combined DNA Index System known as CODIS, an FBI database of criminal suspects' biometric data, had matched the DNA to a known offender Ward-Smith.

Convicted felons are required to submit DNA for the database.

Ward-Smith has a relatively lengthy criminal history, according to court records, that includes felony convictions for conspiracy to possess with intent to deliver a controlled substance in 2015 and retail theft in 2017.

But when police got word of the hit, the defendant's whereabouts were unknown. That changed, however, when he got picked up and placed in the Butler County Prison for a probation violation in June 2018.

Police subsequently interviewed him at the prison. He denied he had anything to do with the thefts from the vehicles. He also claimed he was unfamiliar with Kemar Drive where the cigarette butt, allegedly with his DNA on it, was found.

This is an excerpt of an article appearing in Thursday's Butler Eagle. To read the full story, pick up today's newspaper or subscribe online.

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DNA from discarded cigarette leads to arrest in 3-year-old case - Butler Eagle

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Countering the Negative Effects of a Common Antidepressant – Tufts Now

Posted: at 5:22 pm

Selective serotonin reuptake inhibitors, or SSRIs, are popular drugs that treat depression by increasing the amount of a neurotransmitter called serotonin in the brain. But when a common SSRI known as sertraline is taken by women during pregnancy, there is a small risk that it can have adverse side effects on childrens development.

Now a Tufts team, including three undergraduates, have found that the birth defects might result from sertraline directly damaging a cells genetic information, or DNAand that one potential way to counter this effect is with antioxidants such as vitamin C. Their results were published recently in Scientific Reports.

To study the issue, Michael Levin, A92, Vannevar Bush Professor of Biology, and Mitch McVey, a professor of molecular biology who specializes in fruit fly genetics and DNA repair, worked with undergraduates Catherine Donlon, A16, Arpita Jajoo, A19, and Sarah Shnayder, A20.

Donlon spearheaded the project in McVeys lab as part of her senior honors thesis. To see if sertraline affected baby flies like it does children, Donlon raised thousands of fruit flies in the lab, feeding the mothers sertraline-laced sugar water.

When Donlon didnt see a clear effect on the baby flies, she instead tried feeding sertralinewhich is better known under its brand name Zoloftto the developing fruit fly larvae. Although fruit fly larvae do not develop inside their mothers, they somewhat resemble human embryos in that their organs and bodies continue to develop over time.

Based on whats known about some of the developmental effects seen in children of mothers who take sertraline for mental disorders, Donlon hypothesized that sertraline-eating larvae would develop more slowly than other larvae.

But in fact almost half of the larvae that consumed sertraline died before reaching the final stage in their development. McVey was struck by Donlons results. What surprised me the most is that people have looked at the effects of sertraline in human cell culture and in mice in the past, and they havent seen any real toxicity, he said. Sertraline didnt seem to have much effect on the mice, which is one reason that this drug has been on the market for so long, and its been so successful.

At the same time, serotonin has been shown to be a key player in embryonic patterning in other model systems; this is why other SSRIs are known to cause birth defects in vertebrates, Levin said. Cells were using this neurotransmitter molecule to communicate about how to make an embryo long before neurons evolved.

McVey and Levins team then sought to determine how sertraline killed the larvae. Was it that the larvae died because of sertralines effects on serotonin levels, or because of some innate toxicity of the drug?

Jajoo repeated Donlons experiment, but also included some fruit fly larvae that lack the protein responsible for transporting serotonin back into cells. Without this protein, serotonin levels should be higher than normal outside of cells.

If those flies developed slowly, then serotonin might be to blame for the deaths. But if sertraline-eating larvae develop even slower than these flies, then the drug itself might be directly damaging cells DNAwhich is exactly what Jajoo found.

To confirm that the drug directly damages the flies DNA, Jajoo bathed developing wing tissues in sertraline and used a staining technique that visualizes the number of double-stranded breaks in the DNA. Wing tissues bathed in sertraline showed three times the normal number of double-stranded DNA breaks, suggesting that sertraline might cause birth defects by directly damaging the genetic code of developing embryos.

Donlon, now a medical student at New York Medical College, put the use of the drug by expectant mothers in perspective. I think its great to understand the mechanism of how things like sertraline work, but its also really important to understand the reason why medications are prescribed in the first place, she said.

Jajoo, also a medical student now, echoed Donlons view. You have to think about two patients, she said. You have to think about both the developing fetus and the mother, and if the mother needs this SSRI for her wellbeing, then instead of saying, OK, this is damaging, take it away, it would be awesome if it was, OK, this is damaging, we know how, lets fix it.

The team approached their next experiment with this mindset. Levin had a hunch that the damage to the DNA might be caused by reactive oxygen species, an unstable molecule containing oxygen that readily reacts with other molecules and that can be dangerous to cells if not balanced within the body.

There was this great breakthrough moment, said Jajoo, where I was sitting in a meeting with both Mitch [McVey] and Mike [Levin] and Mike said, Well, if its oxidative, can we just throw an antioxidant at it? And we all kind of laughed and then we were like, Wait, can we?

They could and did. The team fed fruit fly larvae both sertraline and vitamin C, a powerful antioxidant, and saw that almost all of the larvae survived. Additionally, they found significantly fewer double-stranded DNA breaks. This supported the idea that the sertraline-induced DNA damage results from reactive oxygen species.

But they didnt definitively show that, McVey said. It would be nice to know how sertraline is interacting with DNAif it isand causing damage. Or is it an indirect effect?

McVey and Levin hope to pursue these questions in the future; according to McVey, theyre just waiting for the right student to work on the project.

Gina Mantica, a graduate student in biology, can be reached at gina.mantica@tufts.edu.

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Canada: DNA discovery lends weight to First Nations ancestral story – The Guardian

Posted: at 5:22 pm

When a woman named Shanawdithit died from tuberculosis in Newfoundland nearly 200 years ago, it was widely believed that her death marked a tragic end to her peoples existence.

For centuries, the Beothuk had thrived along the rocky shores of the island, taking on a near-mythical status as descendants of the first people encountered by Norse explorers in what is now Canada. But their population was devastated by decades of starvation and diseases, and when she died in 1829, Shanawdithit was believed to be the last of her line.

New research from Memorial University, however, has found Beothuk DNA probably still exists in people alive today a discovery that would rewrite the history of the Newfoundlands early inhabitants, even as it confirms the accuracy of local First Nations oral tradition.

Weve got good evidence that we have genetic continuity from the Beothic into modern persons, said biologist Dr Steve Carr.

But while the finding would trigger a rethink for historians, the notion is not surprising to local Indigenous groups.

Mikmaq oral history has long asserted a shared ancestry with the original inhabitants of Newfoundland, and local First Nations have worked closely with Carr to help lend genetic evidence to their own traditions.

There were always connections or friendly relations going back more than 200 years ago and when you mingle that way, periodically, things would happen, said Chief Misel Joe of the Miawpukek Mikamawey Mawiomi, a Mikmaq First Nation in Newfoundland.

Historians believe the Beothuk are descended from a group that braved the ocean to cross from Labrador to Newfoundland thousands of years ago and whose distinct culture emerged around 1500 CE. At one point, as many as 2,000 Beothuk lived in communities scattered around Newfoundland.

For generations, they largely resisted and avoided relations with European settlers; the few interactions between the two were defined by violent encounters.

Early European settlements on the coast cut off Beothuk access to critical salmon and seals forcing them to move further inland where they sustained themselves on caribou before finally succumbing to starvation and disease.

But Carrs research suggests it was only a cultural extinction; their genetic legacy lives on.

In his study, Carr used DNA samples from Shanawdithits aunt and uncle Demasduit and Nonosbawsut whose skulls were sent to the University of Edinburgh in the 1850s. After a long campaign by Chief Joes community, the remains were repatriated to Newfoundland from National Museums Scotland in March.

After running samples through a genetics database, Carr was able to find his smoking gun a man in Tennessee who was genetically similar to Nonosbawsut, but had no known Indigenous ancestry.

With only a small amount of data to work with, Carr hopes more samples will further demonstrate a connection.

Its easy to obtain the DNA sequence from somebody and you can count the number of similarities. Thats a very easy thing to do. But to reconstruct the patterns of a relationship is a very challenging problem, said Carr, adding that further research into the known movement and connections between the Beothuk and Mimaq was still required.

The findings also illustrate the way in which genetic uniqueness in this case the distinct sequence of Beothuk mitochondrial genomes can persist intact for generations. While humans share an immense amount of DNA that traces back millennia, said Carr, the intent of his research lay in teasing out the subtle and distinguishing differences between known groups.

For years, academia has ignored the oral histories of Indigenous peoples, said Chief Joe.

Academics are hard people to convince. They often have this mindset that this the way it was no matter what information we give them to the contrary, he said.

He described a frustrating experience in a land claims court, where the adjudicator suggested the Mikmaq first arrived in Newfoundland in the 1700s.

But we have an oral history of British sailors meeting our people and asking for directions. We drew them a map on birch bark. If this is the first time we had ever been on the land, how could we draw a map? said Joe.

Its convenient for government, for everyone, to ignore people who had no written history

The community is excited to keep working with Carr on further testing, said Joe, to further strengthen the evidence of shared ancestry.

This is a big thing for us, he said. But it all comes from something we already knew.

This article was amended on 11 May 2020. An earlier version incorrectly said that the skulls of Demasduit and Nonosbawsut were taken to the Royal Museum in Scotland in 1828.

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Canada: DNA discovery lends weight to First Nations ancestral story - The Guardian

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‘Rick and Morty’s Anthology Episodes Share the Most DNA with ‘Community’ – Decider

Posted: at 5:22 pm

At times its hard to believe that two of the most beloved cult comedies in modern television came from the same mind. Rick and Morty, with its bristling introspection and depressive streaks, often feels far removed from the loving silliness of Community. But theres one moment in every season of Adult Swims animated mega-hit that unites Dan Harmons two creations. Rick and Mortys anthology episodes channel Communitys love of meta mockery and human connection better than any other part of this series.

Even after the premiere of shows such as Westworld, Mr. Robot, and yes, Rick and Morty, no show was quite as meta as Community. As early as Season 2 the NBC comedy was packed with in-jokes, like pulling a Britta or the many, barely noticeable adventures Abed (Danny Pudi) had in the background of many episodes. But what Community always excelled at during even its most ridiculous moments was finding new ways to mock itself.

The savage edge of that mockery appears most clearly in Season 3. In the 2010s it was rare for a network sitcom to be so full of inside jokes and callbacks that it was nearly impossible for casual viewers to watch. But thats exactly what Community became. The full ridiculousness of Documentary Filmmaking: Redux doesnt come across if you didnt see Season 2s intimate and deceptive Intermediate Documentary Filmmaking. Both Urban Matrimony and the Sandwich Arts and Digital Estate Planning fall flat without sitting through literal hours of Shirleys (Yvette Nicole Brown) passive aggression and Pierces (Chevy Chase) bumbling form of offensiveness. Similarly no other show could have ever pulled off something as bizarre, thought-provoking, and imaginative as Remedial Chaos Theory without establishing seasons of character development.

So many episodes in the later seasons of Community happily tore apart what this show was, challenging its sitcom premises, questioning the study groups status as this shows heroes, and painfully digging into its characters to find something more interesting than the average half-hour. Those sorts of explorations have always been an area where Rick and Morty has excelled. But its in each seasons anthology episode that the series really takes a meta step back and examines what it is, not as a piece of pop culture mocking other pieces of pop culture but as a show in and of itself. That more than anything else is pure Community.

Yet in between all of these funny moments and meta musings there was something else in these episodes reminiscent of Community: connection. Community was always true to its name. It was a show about lost people finding a family in each other, and as a result each episode typically ended on a loving, uplifting note. Though its never so loving, Rick and Mortys anthology episodes have often revealed a deeper understanding of Rick Sanchez and the Smith family than other installments. There was Mortys vulnerable plea for Summer to stay in Rixty Minutes; their fear then budding realization about Jerrys uselessness in Interdimensional Cable 2: Tempting Fate; Mortys growing understanding of his grandpa in Mortys Mind Blowers; and Ricks drunken rant that terrifies Morty in Never Ricking Morty. So much of the growth in this show is introspective and incomplete. But on the outskirts of these clip episodes this family typically connects in ways weve never seen them before. The result is often murky, dark, and unsettling but that base human connection is still happening.

Years before Rick and Morty were ever laughing at Interdimensional Cable, Community had a clip show of its own. Season 2s Paradigms of Human Memory saw the study group reflecting on a series of past adventures, none of which ever happened on screen. The entire half-hour is constructed to be a biting takedown of lazy anthology episodes that typically appear in TV comedies. But watching it now theres something more between the episodes hinting at future spinoffs like Regional Holiday Music and cutting together shipping videos deliberately mocking fans. The seeds of Rick and Mortys decidedly more acidic brand of comedy can be seen.

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Where to stream Community

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'Rick and Morty's Anthology Episodes Share the Most DNA with 'Community' - Decider

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DNA/Gene Microarray Market to Reach US$ 7,693.0 Million globally by end of 2027, Owing to Significant Developments in Personalized Medicines – CMI -…

Posted: at 5:21 pm

SEATTLE, May 13, 2020 (GLOBE NEWSWIRE) -- Traditional solid-phase array and alternative bead array are some of the types of DNA microarray. Major applications of DNA/Gene microarray include, genomics, gene expression, Single Nucleotide Polymorphism (SNP) analysis, and proteomics.

The global DNA/gene microarray market is estimated to account for US$ 3,018.3 Mn in terms of value in 2020 and is expected to reach US$ 7,693.0 Mn by the end of 2027.

Global DNA/Gene Microarray Market: Drivers

Significant developments in personalized medicines is expected to fuel growth of the global DNA/gene microarray market over the forecast period. For instance, in April 2020, Indivumed GmbH, an oncology company, launched the Oncology Alliance for Individualized Medicine, an international collaborative alliance to advance personalized medicine in cancer through IndivuType, the companys multi-omics database.

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Global DNA/Gene Microarray Market: Opportunities

Increasing investment in DNA sequencing is expected to offer lucrative growth opportunities for players in the market. For instance, in January 2020, Element Biosciences, a biotechnology startup, raised US$ 80 million to develop DNA sequencing platform.

Global DNA/Gene Microarray Market: Restraints

Presence of alternative technologies is expected to hamper growth of the global DNA/gene microarray market. Protein chip and lab-on-chip, glycomic arrays, tissue arrays, and cell arrays are some of the alternatives to DNA/gene microarray.

Key Takeaways:

The global DNA/gene microarray market was valued at US$ 2,640.7 Mn in 2019 and is forecast to reach a value of US$ 7,693.0 Mn by 2027 at a CAGR of 12.4% between 2020 and 2027. The market is expected to witness significant growth owing to increasing technological advancement in microarray technology, and increasing demand for genetic testing.

Gene expression and SNP analysis segment held dominant position in the global DNA/gene microarray market in 2019, accounting for 25.6% share in terms of value, followed by oncology and drug development, respectively. Increasing drug development, and demand for personalized medicine is expected to support growth of the segment over the forecast period.

North America held dominant position in the global DNA/gene microarray market in 2019, accounting for 34.1% share in terms of value, followed by Europe and Asia Pacific, respectively. North America has presence of leading manufacturers, and wide number of research institutes which make use of these products. These factors are expected to support growth of the market over the forecast period.

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Market Trends

The market is witnessing launch of new genetic tests. For instance, in July 2019, MyHeritage, an online genealogy platform with web, mobile, and software products and services, launched new Health+Ancestry test, a health-related genetic test.

The market is also witnessing increasing adoption of nanoarrays, owing to their various advantages in terms of sensitivity, specificity, speed, portability, throughput, and cost. Nanoarrays find application in drug discovery and disease diagnosis.

Global DNA/Gene Microarray Market: Competitive Landscape

Major players operating in the global DNA/gene microarray market include, Affymetrix, Inc., Illumina, Inc., Agilent Technologies Inc., Roche NimbleGen Inc., Sequenom, Inc., Biometrix Technology Inc., LC Sciences, Life Technologies Corp., Lifegen Technologies LLC, Microarrays Inc.

Global DNA/Gene Microarray Market: Key Developments

Major players in the market are focused on launching new products to expand their product portfolio. For instance, in February 2020, Twist Bioscience Corporation launched the Twist Targeted Methylation Sequencing Solution to study methylation pattern changes in a wide range of research fields including cancer

Major players in the market are also focused on adopting M&A strategies to expand their product portfolio. For instance, in December 2019, Oncology Pharma, Inc. signed a Letter of Intent to acquire at least a 50% stake in Diagnomics, Inc., a private CLIA certified & CAP accredited private molecular Genomics lab and provider of DNA microarrays, Next Generation Sequencing, and real-time PCR solutions

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Segmentation

Related Topics:

CELL & TISSUE CULTURE SUPPLIES MARKET

Cell and tissue culture supplies are used in biotechnology, cell therapy, and regenerative medicine field. Successful plant cell/tissue culture requires high quality and dependable culture media. Various instruments that are used for cell and tissue culturing are plates, flasks, culture bags, pipetting instruments, incubators, cryostorage equipment, biosafety cabinets, and others. Increasing application of cell and tissue culture is expected to boost growth of the global cell and tissue culture supplies market over the forecast period.

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DNA/Gene Microarray Market to Reach US$ 7,693.0 Million globally by end of 2027, Owing to Significant Developments in Personalized Medicines - CMI -...

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Genealogy And DNA Testing With Libby Copeland On Wednesday’s Access Utah – Utah Public Radio

Posted: at 5:21 pm

Wednesday's Access Utah episode.

You swab your cheek or spit into a vial, then send it away to a lab somewhere. Weeks later you get a report that might tell you where your ancestors came from or if you carry certain genetic risks. Or the report could reveal a long-buried family secret and upend your entire sense of identity.

In The Lost Family: How DNA Testing is Upending Who We Are, journalist Libby Copeland investigates what happens when we embark on a vast social experiment with little understanding of the ramifications. Copeland explores the culture of genealogy buffs, the science of DNA, and the business of companies like Ancestry and 23andMe, all while tracing the story of one woman, her unusual results, and a relentless methodical drive for answers that becomes a thoroughly modern genetic detective story.

Libby Copeland is an award-winning journalist and author who writes from New York about culture, science, and human behavior. As a freelance journalist, she writes for such media outlets as The Atlantic, Slate, New York, Smithsonian, The New York Times, The New Republic, Esquire.com, The Wall Street Journal, Fast Company, and Glamour.

A graduate of the University of Pennsylvania, she was a 2010 media fellow at Stanford Universitys Hoover Institution. Her article for Esquire.com, Kates Still Here, won Hearst Magazines 2017 Editorial Excellence Award for reported feature or profile. She previously won first prize in the feature specialty category from the Society for Features Journalism (then called AASFE). She lives in Westchester, NY, with her husband and two children.

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Genealogy And DNA Testing With Libby Copeland On Wednesday's Access Utah - Utah Public Radio

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DNA and RNA Sample Preparation Kits Market Growth by Top Companies, Trends by Types and Application, Forecast to 2026 – Cole of Duty

Posted: at 5:21 pm

Thermo Fisher Scientific

Moreover, the DNA and RNA Sample Preparation Kits report offers a detailed analysis of the competitive landscape in terms of regions and the major service providers are also highlighted along with attributes of the market overview, business strategies, financials, developments pertaining as well as the product portfolio of the DNA and RNA Sample Preparation Kits market. Likewise, this report comprises significant data about market segmentation on the basis of type, application, and regional landscape. The DNA and RNA Sample Preparation Kits market report also provides a brief analysis of the market opportunities and challenges faced by the leading service provides. This report is specially designed to know accurate market insights and market status.

By Regions:

* North America (The US, Canada, and Mexico)

* Europe (Germany, France, the UK, and Rest of the World)

* Asia Pacific (China, Japan, India, and Rest of Asia Pacific)

* Latin America (Brazil and Rest of Latin America.)

* Middle East & Africa (Saudi Arabia, the UAE, , South Africa, and Rest of Middle East & Africa)

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Table of Content

1 Introduction of DNA and RNA Sample Preparation Kits Market

1.1 Overview of the Market1.2 Scope of Report1.3 Assumptions

2 Executive Summary

3 Research Methodology

3.1 Data Mining3.2 Validation3.3 Primary Interviews3.4 List of Data Sources

4 DNA and RNA Sample Preparation Kits Market Outlook

4.1 Overview4.2 Market Dynamics4.2.1 Drivers4.2.2 Restraints4.2.3 Opportunities4.3 Porters Five Force Model4.4 Value Chain Analysis

5 DNA and RNA Sample Preparation Kits Market, By Deployment Model

5.1 Overview

6 DNA and RNA Sample Preparation Kits Market, By Solution

6.1 Overview

7 DNA and RNA Sample Preparation Kits Market, By Vertical

7.1 Overview

8 DNA and RNA Sample Preparation Kits Market, By Geography

8.1 Overview8.2 North America8.2.1 U.S.8.2.2 Canada8.2.3 Mexico8.3 Europe8.3.1 Germany8.3.2 U.K.8.3.3 France8.3.4 Rest of Europe8.4 Asia Pacific8.4.1 China8.4.2 Japan8.4.3 India8.4.4 Rest of Asia Pacific8.5 Rest of the World8.5.1 Latin America8.5.2 Middle East

9 DNA and RNA Sample Preparation Kits Market Competitive Landscape

9.1 Overview9.2 Company Market Ranking9.3 Key Development Strategies

10 Company Profiles

10.1.1 Overview10.1.2 Financial Performance10.1.3 Product Outlook10.1.4 Key Developments

11 Appendix

11.1 Related Research

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DNA and RNA Sample Preparation Kits Market Growth by Top Companies, Trends by Types and Application, Forecast to 2026 - Cole of Duty

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King Dalindyebo gets backing of AbaThembu faction in royal DNA drama – News24

Posted: at 5:21 pm

15:51 14/05/2020 Malibongwe Dayimani

A faction of the AbaThembu royal family, which has previously failed to have acting king Azenathi Dalindyebo removed from the throne, has joined King Buyelekhaya Dalindyebo in a bid to force his ex-wife Buyiswa Majiki and son Azenathi to conduct a paternity test.

The statement on Thursday, issued by the chairperson of the Ngangelizwe royal family, Prince Thanduxolo Mtirara, comes after Buyelekhaya Dalindyebo wrote WhatsApp messages to Majiki and Azenathi on Tuesday, telling them he never fathered the 26-year-old and that he wanted a DNA test conducted.

Bad blood between the father and son started in 2016 when Azenathi defied his father and made moves to become acting king when Buyelekhaya was sent to prison for 12 years after being found guilty of seven counts of kidnapping, three assaults, three arson and one of defeating the ends of justice - for terrorising his subjects in the 1990s.

In December last year, Buyelekhaya was released from prison after serving four years of his jail term. He was released as part of a remission process announced by President Cyril Ramaphosa just before Christmas.

But the king was re-arrested on 13 March at the Bumbane Great Place after he stormed the palace armed with an axe.

Azenathi, his wife, Usikhumbulile, 22, and three-year-old son Onesisa were chased out at around 3am.

Buyelekhaya is due in court on 1 June after he was released on a warning.

In response, Azenathi obtained a court order and asked the government to allocate VIP protection police officers at the gates of the palace, to prevent his father from entering.

READ |Dalindyebo disowns son, demands DNA test

This week, the controversial family made headlines again after the king launched into a tirade of abuse, with strongly worded messages to Majiki and Azenathi.

Attacking the Eastern Cape High Court judge, Buyelekhaya said: "Judges like your good self belong to [sic] garbage bin of law society."

He also ordered Azenathi to vacate the palace, before saying: "You are not my biological son and I am not your biological father. If you are disputing this, let's do a DNA test."

In a message written in isiXhosa to Majiki, which News24 has seen,Buyelekhaya said: "Good morning Buyiswa I am requesting you, me and Azenathi to conduct a DNA test."

READ | AbaThembu king released on warning for assault, damage to property

Switching to English, he continued: "We need to do this as soon as possible I need you to respond within 24 hours. In view of the pending cases [protection order] kindly consider one month or more for us to get results, all at my cost".

Several efforts made by News24 to get comment from Majiki drew a blank at the time of writing on Thursday. These included phone calls and text messages.

Azenathi's spokesperson Siganeko Dalindyebo said the acting king would issue a statement responding to his father at a later stage.

In his statement, Mtirara condemned the media for running stories about the royal drama, before referring to Azenathi as an "alleged son".

Mtirara said Azenathi was born out of wedlock and not once in the history of the AbaThembu kingdom has a son born out of wedlock ascended the throne.

"We similarly acknowledge that King (Buyelekhaya) ZwelibanziDalindyebo is well within his rights to request DNA or paternity testing be done, should he deem it fit, or need certainty in respect of his alleged son. There is nothing untoward with regards to that."

Mtirara said the paternity was not a new issue among the AbaThembu family.

"Before his release from prison in December 2019, King Zwelibanzi Dalindyebo had indicated to some senior members of the AbaThembu royal family that one of the reasons he was seeking parole was to resolve some issues in his personal household in order to restore stability in the Kingdom of AbaThembu."

Mtirara said: "Among those issues, were issues regarding his son's (Azenathi Dalindyebo) paternity. At the time, what was not discussed were the modalities of how such issues were to be handled or dealt with; furthermore, the extent in which the royal family was to be involved, if any."

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King Dalindyebo gets backing of AbaThembu faction in royal DNA drama - News24

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Direct to Consumer (DTC) DNA Test Kits Market Growth by Top Companies, Trends by Types and Application, Forecast to 2026 – Cole of Duty

Posted: at 5:21 pm

Helix OpCo LLC

Moreover, the Direct to Consumer (DTC) DNA Test Kits report offers a detailed analysis of the competitive landscape in terms of regions and the major service providers are also highlighted along with attributes of the market overview, business strategies, financials, developments pertaining as well as the product portfolio of the Direct to Consumer (DTC) DNA Test Kits market. Likewise, this report comprises significant data about market segmentation on the basis of type, application, and regional landscape. The Direct to Consumer (DTC) DNA Test Kits market report also provides a brief analysis of the market opportunities and challenges faced by the leading service provides. This report is specially designed to know accurate market insights and market status.

By Regions:

* North America (The US, Canada, and Mexico)

* Europe (Germany, France, the UK, and Rest of the World)

* Asia Pacific (China, Japan, India, and Rest of Asia Pacific)

* Latin America (Brazil and Rest of Latin America.)

* Middle East & Africa (Saudi Arabia, the UAE, , South Africa, and Rest of Middle East & Africa)

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Table of Content

1 Introduction of Direct to Consumer (DTC) DNA Test Kits Market

1.1 Overview of the Market1.2 Scope of Report1.3 Assumptions

2 Executive Summary

3 Research Methodology

3.1 Data Mining3.2 Validation3.3 Primary Interviews3.4 List of Data Sources

4 Direct to Consumer (DTC) DNA Test Kits Market Outlook

4.1 Overview4.2 Market Dynamics4.2.1 Drivers4.2.2 Restraints4.2.3 Opportunities4.3 Porters Five Force Model4.4 Value Chain Analysis

5 Direct to Consumer (DTC) DNA Test Kits Market, By Deployment Model

5.1 Overview

6 Direct to Consumer (DTC) DNA Test Kits Market, By Solution

6.1 Overview

7 Direct to Consumer (DTC) DNA Test Kits Market, By Vertical

7.1 Overview

8 Direct to Consumer (DTC) DNA Test Kits Market, By Geography

8.1 Overview8.2 North America8.2.1 U.S.8.2.2 Canada8.2.3 Mexico8.3 Europe8.3.1 Germany8.3.2 U.K.8.3.3 France8.3.4 Rest of Europe8.4 Asia Pacific8.4.1 China8.4.2 Japan8.4.3 India8.4.4 Rest of Asia Pacific8.5 Rest of the World8.5.1 Latin America8.5.2 Middle East

9 Direct to Consumer (DTC) DNA Test Kits Market Competitive Landscape

9.1 Overview9.2 Company Market Ranking9.3 Key Development Strategies

10 Company Profiles

10.1.1 Overview10.1.2 Financial Performance10.1.3 Product Outlook10.1.4 Key Developments

11 Appendix

11.1 Related Research

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Direct to Consumer (DTC) DNA Test Kits Market Growth by Top Companies, Trends by Types and Application, Forecast to 2026 - Cole of Duty

Posted in DNA | Comments Off on Direct to Consumer (DTC) DNA Test Kits Market Growth by Top Companies, Trends by Types and Application, Forecast to 2026 – Cole of Duty

UC Berkeley lab pivots from editing DNA to processing COVID-19 tests – Berkeleyside

Posted: March 31, 2020 at 6:48 am

Postdoctoral fellows Jenny Hamilton and Enrique Shao with an automated liquid-handling robot (Hamilton STARlet) that will be used to analyze swabs from patients to diagnose COVID-19. Hamilton and Shao volunteered to train to become CLIA certified so as to process patient samples. When analyzing real samples from patients, they would be wearing full personal protective equipment (PPE), including mask, face shield, gown and gloves. Photo: Max & Jules Photography/UC Berkeley

What happens when you combine a viral pandemic, an empty laboratory and a bunch of biologists whove been forced to put their regular work on pause?

In a matter of days, a UC Berkeley science building has converted to a COVID-19 test processing center, with researchers hoping to enable up to thousands more coronavirus tests per day in the East Bay.

The Innovative Genomics Institute at Berkeley Way and Oxford Street founded by Jennifer Doudna, co-developer of gene-editing technology CRISPR houses robots that will process samples from nearby medical centers and return the results in 12-24 hours instead of the usual several days, scientists say. The initiative is set to begin processing samples from UC Berkeleys Tang Center by the end of the week, but the researchers hope to expand the effort to other medical clinics in the region too.

We put in place a robotic pipeline for doing thousands of tests per day, with a pipeline for managing the data and getting it back to clinicians, said Doudna in a statement from IGI. Imagine setting that up a process that would normally take months to years in a couple of weeks. Its really extraordinary and not something Ive ever seen in my career.

The initiative is launching as reports abound of shortages and delays at every point in the coronavirus testing process across California and the United States. The city of Berkeley does not know how many people in Berkeley have been tested for the virus because, until a recent order, labs were only required to report positive results.

The IGI initiative will use a common technique called RT-PCR, which enables the detection of viral RNA in samples.

After UC Berkeley shuttered its labs and the novel coronavirus began spreading throughout the area, many scientists were hoping to apply their expertise to the local mitigation effort. About 800 faculty, graduate students and community members immediately volunteered to help out with the Berkeley effort, according to IGI.

My own research is shut down and theres not very much I can do other than stay in my home, said Ph.D. student Holly Gildea, who early in the effort put out a Bay Area-wide call for chemical substances needed to process the samples. Someone on Twitter compared this to being on a plane andsomeone asking for doctor finally Im useful.

Around 30 people mostly PhD students and postdoctoral researchers are currently being trained to oversee the process and babysit the robots, said Jenny Hamilton, postdoctoral researcher.

The volunteers were selected for their experience working with unsafe materials people who have the training to do clean practices and people who have the skillset needed, Hamilton said.

One UC Berkeley Ph.D. student who asked not to be named, however, said she was concerned that this front-line work is being done by volunteers instead of the initiative paying the skilled researchers.

Although IGI will receive samples after theyre collected at the clinic, the initiative will also supply Tang and other medical centers with the tubes and swabs they need to conduct the tests, aiming to significantly increase their testing capacity. The critical items are in short supply these days, so the Berkeley scientists have spent the past week or so seeking out products from non-traditional distributors around the world. They had to ask health care workers whether theyd be willing to use the slightly different products than theyre used to, but they were largely eager to accept any new testing materials, Hamilton said.

Everything in this process is limiting, she said. The major thing weve been doing in the past week is to secure a supply chain.

Revised guidelines from federal health authorities and Gov. Gavin Newsoms emergency declaration also permitted expedited approval for the initiative, according to the IGI statement.

The Berkeley researchers are working with UC San Francisco and the Chan Zuckerberg Biohub on the sample processing work. The initiative was also inspired by similar work being done at the University of Washington, Hamilton said.

The effort is also getting underway just asthe Berkeley Lab (not located in the IGI building) reported its first employee who tested positive for COVID-19. There is no indication that he got the virus while at work, however, and the lab stressed that cases are likely across all workplaces.

Hamilton said there will only be a few people in the IGI lab at a given time, always practicing social distancing.

Im much more concerned about someone catching SARS-CoV-2 at Berkeley Bowl than I am about anyone being exposed from one of these samples, she said.

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Here is the original post:
UC Berkeley lab pivots from editing DNA to processing COVID-19 tests - Berkeleyside

Posted in DNA | Comments Off on UC Berkeley lab pivots from editing DNA to processing COVID-19 tests – Berkeleyside

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