Sprott, R. L. Biomarkers of aging and disease: introduction and definitions. Exp. Gerontol. 45, 24 (2010).
CAS PubMed Google Scholar
Bell, C. G. et al. DNA methylation aging clocks: challenges and recommendations. Genome Biol. 20, 249 (2019).
PubMed PubMed Central Google Scholar
Horvath, S. & Raj, K. DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nat. Rev. Genet. 19, 371384 (2018).
CAS PubMed Google Scholar
Schultz, M. B. et al. Age and life expectancy clocks based on machine learning analysis of mouse frailty. Nat. Commun. 11, 4618 (2020).
CAS PubMed PubMed Central Google Scholar
Bobrov, E. et al. PhotoAgeClock: deep learning algorithms for development of non-invasive visual biomarkers of aging. Aging 10, 32493259 (2018).
PubMed PubMed Central Google Scholar
Lehallier, B. et al. Undulating changes in human plasma proteome profiles across the lifespan. Nat. Med. 25, 18431850 (2019).
CAS PubMed PubMed Central Google Scholar
Fleischer, J. G. et al. Predicting age from the transcriptome of human dermal fibroblasts. Genome Biol. 19, 221 (2018).
CAS PubMed PubMed Central Google Scholar
Horvath, S. DNA methylation age of human tissues and cell types. Genome Biol. 14, R115 (2013).
PubMed PubMed Central Google Scholar
Hannum, G. et al. Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol. Cell 49, 359367 (2013).
CAS PubMed Google Scholar
Levine, M. E. et al. An epigenetic biomarker of aging for lifespan and healthspan. Aging 10, 573591 (2018).
PubMed PubMed Central Google Scholar
Petkovich, D. A. et al. Using DNA methylation profiling to evaluate biological age and longevity interventions. Cell Metab. 25, 954960 (2017).
CAS PubMed PubMed Central Google Scholar
Meer, M. V., Podolskiy, D. I., Tyshkovskiy, A. & Gladyshev, V. N. A whole lifespan mouse multi-tissue DNA methylation clock. eLife 7, e40675 (2018).
PubMed PubMed Central Google Scholar
Thompson, M. J. et al. A multi-tissue full lifespan epigenetic clock for mice. Aging 10, 28322854 (2018).
CAS PubMed PubMed Central Google Scholar
Levine, M. et al. A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin. eLife 9, e59201 (2020).
CAS PubMed PubMed Central Google Scholar
Robeck, T. R. et al. Multi-species and multi-tissue methylation clocks for age estimation in toothed whales and dolphins. Commun. Biol. 4, 642 (2021).
CAS PubMed PubMed Central Google Scholar
Wilkinson, G. S. et al. DNA methylation predicts age and provides insight into exceptional longevity of bats. Nat. Commun. 12, 1615 (2021).
CAS PubMed PubMed Central Google Scholar
Wang, T. et al. Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and rapamycin treatment. Genome Biol. 18, 57 (2017).
PubMed PubMed Central Google Scholar
Horvath, S. et al. Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies. Aging 10, 17581775 (2018).
CAS PubMed PubMed Central Google Scholar
Lu, Y. et al. Reprogramming to recover youthful epigenetic information and restore vision. Nature 588, 124129 (2020).
CAS PubMed PubMed Central Google Scholar
Kerepesi, C., Zhang, B., Lee, S.-G., Trapp, A. & Gladyshev, V. N. Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging. Sci. Adv. 7, eabg6082 (2021).
CAS PubMed PubMed Central Google Scholar
Lu, A. T. et al. DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging 11, 303327 (2019).
CAS PubMed PubMed Central Google Scholar
Pidsley, R. et al. Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling. Genome Biol. 17, 208 (2016).
PubMed PubMed Central Google Scholar
Meissner, A. et al. Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis. Nucleic Acids Res. 33, 58685877 (2005).
CAS PubMed PubMed Central Google Scholar
Han, Y. et al. Epigenetic age-predictor for mice based on three CpG sites. eLife 7, e37462 (2018).
PubMed PubMed Central Google Scholar
Han, Y. et al. New targeted approaches for epigenetic age predictions. BMC Biol. 18, 71 (2020).
CAS PubMed PubMed Central Google Scholar
Han, Y. et al. Targeted methods for epigenetic age predictions in mice. Sci. Rep. 10, 22439 (2020).
CAS PubMed PubMed Central Google Scholar
Wang, T. et al. Quantitative translation of dog-to-human aging by conserved remodeling of the DNA methylome. Cell Syst. 11, 176185 (2020).
PubMed PubMed Central Google Scholar
Wendt, J., Rosenbaum, H., Richmond, T. A., Jeddeloh, J. A. & Burgess, D. L. Targeted bisulfite sequencing using the SeqCap Epi enrichment system. Methods Mol. Biol. 1708, 383405 (2018).
CAS PubMed Google Scholar
Mulqueen, R. M. et al. Highly scalable generation of DNA methylation profiles in single cells. Nat. Biotechnol. 36, 428431 (2018).
CAS PubMed PubMed Central Google Scholar
Rohland, N. & Reich, D. Cost-effective, high-throughput DNA sequencing libraries for multiplexed target capture. Genome Res. 22, 939946 (2012).
CAS PubMed PubMed Central Google Scholar
Wang, M. & Lemos, B. Ribosomal DNA harbors an evolutionarily conserved clock of biological aging. Genome Res. 29, 325333 (2019).
CAS PubMed PubMed Central Google Scholar
Zullo, J. M. et al. Regulation of lifespan by neural excitation and REST. Nature 574, 359364 (2019).
CAS PubMed PubMed Central Google Scholar
Whitehead, J. C. et al. A clinical frailty index in aging mice: comparisons with frailty index data in humans. J Gerontol. A 69, 621632 (2014).
Google Scholar
Watada, E. et al. Age-dependent ribosomal DNA variations in mice. Mol. Cell. Biol. 40, e00368-20 (2020).
CAS PubMed PubMed Central Google Scholar
Rodriguez-Algarra, F. et al. Genetic variation at mouse and human ribosomal DNA influences associated epigenetic states. Genome Biol. 23, 54 (2022).
CAS PubMed PubMed Central Google Scholar
Seligman, B. J., Berry, S. D., Lipsitz, L. A., Travison, T. G. & Kiel, D. P. Epigenetic age acceleration and change in frailty in MOBILIZE Boston. J. Gerontol. A 77, 17601765 (2022).
CAS Google Scholar
Zhou, W. et al. DNA methylation dynamics and dysregulation delineated by high-throughput profiling in the mouse. Cell Genom. 2, 100144 (2022).
CAS PubMed PubMed Central Google Scholar
Lee, M. B., Hill, C. M., Bitto, A. & Kaeberlein, M. Antiaging diets: separating fact from fiction. Science 374, eabe7365 (2021).
CAS PubMed PubMed Central Google Scholar
Baur, J. A. et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444, 337342 (2006).
CAS PubMed PubMed Central Google Scholar
Ocampo, A. et al. In vivo amelioration of age-associated hallmarks by partial reprogramming. Cell 167, 17191733 (2016).
CAS PubMed PubMed Central Google Scholar
Gill, D. et al. Multi-omic rejuvenation of human cells by maturation phase transient reprogramming. eLife 11, e71624 (2022).
CAS PubMed PubMed Central Google Scholar
Matsuyama, M., WuWong, D. J., Horvath, S. & Matsuyama, S. Epigenetic clock analysis of human fibroblasts in vitro: effects of hypoxia, donor age, and expression of hTERT and SV40 largeT. Aging 11, 30123022 (2019).
CAS PubMed PubMed Central Google Scholar
Matsuyama, M. et al. Analysis of epigenetic aging in vivo and in vitro: factors controlling the speed and direction. Exp. Biol. Med. 245, 15431551 (2020).
CAS Google Scholar
Liu, Z. et al. Underlying features of epigenetic aging clocks in vivo and in vitro. Aging Cell 19, e13229 (2020).
CAS PubMed PubMed Central Google Scholar
Gu, H. et al. Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling. Nat. Protoc. 6, 468481 (2011).
CAS PubMed Google Scholar
Lehallier, B., Shokhirev, M. N., Wyss-Coray, T. & Johnson, A. A. Data mining of human plasma proteins generates a multitude of highly predictive aging clocks that reflect different aspects of aging. Aging Cell 19, e13256 (2020).
CAS PubMed PubMed Central Google Scholar
Bruinsma, S. et al. Bead-linked transposomes enable a normalization-free workflow for NGS library preparation. BMC Genomics 19, 722 (2018).
PubMed PubMed Central Google Scholar
Mulqueen, R. M. et al. High-content single-cell combinatorial indexing. Nat. Biotechnol. 39, 15741580 (2021).
CAS PubMed PubMed Central Google Scholar
Nguyen Ba, A. N. et al. Barcoded bulk QTL mapping reveals highly polygenic and epistatic architecture of complex traits in yeast. eLife 11, e73983 (2022).
PubMed PubMed Central Google Scholar
Krueger, F. & Andrews, S. R. Bismark: a flexible aligner and methylation caller for bisulfite-seq applications. Bioinformatics 27, 15711572 (2011).
CAS PubMed PubMed Central Google Scholar
The rest is here:
TIME-seq reduces time and cost of DNA methylation measurement for epigenetic clock construction - Nature.com
- DNA identifies last known remains of victims of notorious Green River Killer, cops say - Miami Herald - January 23rd, 2024 [January 23rd, 2024]
- UNE to study why rare lobsters have strange-colored shells - Spectrum News - January 23rd, 2024 [January 23rd, 2024]
- DNA evidence identifies last known victim of Green River Killer almost 40 years later - NBC Right Now - January 23rd, 2024 [January 23rd, 2024]
- New bill would give California parents more control over whether state can store their kid's DNA - CBS News - January 23rd, 2024 [January 23rd, 2024]
- Lucas County Sheriff's Office doing advanced testing on DNA found at site of 2011 Clarke and Straub murders - WTOL - January 23rd, 2024 [January 23rd, 2024]
- Last known remains connected to the Green River Killer identified through DNA | WTGS - Fox28 Savannah - January 23rd, 2024 [January 23rd, 2024]
- 5 Best Ancestry DNA Tests 2024 To Help You Learn More About Your Health - GLAMOUR UK - January 23rd, 2024 [January 23rd, 2024]
- 11 Investigates: Lucas County Sheriff's Office doing advanced testing on DNA found at site of 2011 Clarke and Straub murders - WTOL - January 23rd, 2024 [January 23rd, 2024]
- Researchers improve blood tests' ability to detect and monitor cancer - MIT News - January 23rd, 2024 [January 23rd, 2024]
- DNA test approved for Duxbury's Lindsay Clancy, who is accused of killing her 3 children - The Patriot Ledger - January 23rd, 2024 [January 23rd, 2024]
- 1,650th victim of 9/11 identified through advanced DNA testing - FOX 17 West Michigan News - January 23rd, 2024 [January 23rd, 2024]
- We Think Cavco Industries (NASDAQ:CVCO) Might Have The DNA Of A Multi-Bagger - Yahoo Finance - January 23rd, 2024 [January 23rd, 2024]
- DNA From the Ocean's 'Twilight Zone' Could Lead to New Lifesaving Drugs, Scientists Say - Smithsonian Magazine - January 23rd, 2024 [January 23rd, 2024]
- Last known remains connected to the Green River Killer identified through DNA - KOMO News - January 23rd, 2024 [January 23rd, 2024]
- 9/11 victim identified as John Ballantine Niven of Oyster Bay with help of DNA technology - WABC-TV - January 23rd, 2024 [January 23rd, 2024]
- Scott Peterson has every right to DNA test: Attorney from case - NewsNation Now - January 23rd, 2024 [January 23rd, 2024]
- DNA from stone age chewing gum sheds light on diet and disease in Scandinavia's ancient hunter-gatherers - The Conversation - January 23rd, 2024 [January 23rd, 2024]
- Barbara Lee responds to Nikki Haley: Racism is in the DNA of this country - The Hill - January 23rd, 2024 [January 23rd, 2024]
- DB Cooper 'will finally be identified' after 53 years due to huge DNA breakthrough - LADbible - January 23rd, 2024 [January 23rd, 2024]
- Dog Owners Who Abandon Poops To Be Found Using DNA Tests in Italy - Newsweek - January 23rd, 2024 [January 23rd, 2024]
- Scientists gather bobcat DNA from paw prints - KJZZ - January 16th, 2024 [January 16th, 2024]
- Discovering Fusions Requires More Than DNA Testing in GI Cancers - OncLive - January 16th, 2024 [January 16th, 2024]
- Largest-ever ocean DNA study uncovers mysteries of marine life - Earth.com - January 16th, 2024 [January 16th, 2024]
- 1st-ever ancient case of Turner syndrome, with just 1 X chromosome instead of 2, found in ancient DNA - Livescience.com - January 16th, 2024 [January 16th, 2024]
- Minnesota Mother Calls on NYS to Allow DNA Testing Finger Lakes Daily News - Finger Lakes Daily News - January 16th, 2024 [January 16th, 2024]
- DNA Didn't Match Marcellus Williams. Missouri May Fast-Track Execution Anyway. - The Intercept - January 16th, 2024 [January 16th, 2024]
- Ancient DNA From Eurasian Herders Sheds Light on the Origins of Multiple Sclerosis - Smithsonian Magazine - January 16th, 2024 [January 16th, 2024]
- DNA's hotel toh kuyabeh mirrors bird flight undulations in tulum - Designboom - January 16th, 2024 [January 16th, 2024]
- Research into ancient DNA sheds new light on cause of Multiple Sclerosis and other neurodegenerative diseases - University of Oxford - January 16th, 2024 [January 16th, 2024]
- Ancient DNA reveals reason for high MS and Alzheimer's rates in Europe - University of Cambridge news - January 16th, 2024 [January 16th, 2024]
- Gilgo Serial Killer Suspect Rex Heuermann Tied to Slaying by DNA From Daughter's Can of Coffee: Prosecutors - The Messenger - January 16th, 2024 [January 16th, 2024]
- DNA evidence leads to arrest of Denton sexual assault suspect - The Cross Timbers Gazette - January 16th, 2024 [January 16th, 2024]
- Ancient DNA reveals reason for high multiple sclerosis and Alzheimer's rates in Europe - EurekAlert - January 16th, 2024 [January 16th, 2024]
- New technique identifies earliest cases of genetic disorders from ancient DNA - University of Oxford - January 16th, 2024 [January 16th, 2024]
- Ancient DNA could be hiding all kinds of health secrets - Deccan Herald - January 16th, 2024 [January 16th, 2024]
- Ancient DNA reveals reason for high MS and Alzheimer's rates in Europe - ScienceBlog.com - January 16th, 2024 [January 16th, 2024]
- Supreme Court seeks government's view on DNA profiling of unidentified bodies - IndiaTimes - January 16th, 2024 [January 16th, 2024]
- Prosecution Ordered to Release Portion of DNA Evidence to Kohberger's Defense Team - bigcountrynewsconnection.com - January 16th, 2024 [January 16th, 2024]
- Judge orders more DNA disclosure in University of Idaho murder case - KXLY Spokane - January 16th, 2024 [January 16th, 2024]
- Cas9-induced targeted integration of large DNA payloads in primary human T cells via homology-mediated end-joining ... - Nature.com - December 14th, 2023 [December 14th, 2023]
- The DNA glycosylase NEIL2 is protective during SARS-CoV-2 infection - Nature.com - December 14th, 2023 [December 14th, 2023]
- How an immune response is driven by one letter difference in DNA - Medical Xpress - December 14th, 2023 [December 14th, 2023]
- Tracy Morgan Discovered He Was Related to Nas After DNA Test - PEOPLE - December 14th, 2023 [December 14th, 2023]
- Scientists testify about DNA in third week of Aguirre trial - The Spokesman Review - December 14th, 2023 [December 14th, 2023]
- DNA metabarcoding focusing on the plankton community: an effective approach to reconstruct the paleo-environment ... - Nature.com - December 14th, 2023 [December 14th, 2023]
- Advancement in DNA Technology and Tenacity of Cold Case Detective Identifies Victim in 37-year-old Homicide - hellowoodlands.com - December 14th, 2023 [December 14th, 2023]
- Integrating DNA methylation and gene expression data in a single gene network using the iNETgrate package ... - Nature.com - December 14th, 2023 [December 14th, 2023]
- Forensic scientist testifies about evidence contamination at state lab in 1986, says knowledge of DNA has since ... - The Spokesman Review - December 14th, 2023 [December 14th, 2023]
- Tracy Morgan Discovers He Is Related To Nas Through DNA Test - BET - December 14th, 2023 [December 14th, 2023]
- DNA discovery opens door to tailored medicine for Indigenous Australians | Australian National University - ANU - December 14th, 2023 [December 14th, 2023]
- Tracy Morgan Started Crying After Learning Hes Related To Nas Through A DNA Test - TODAY - December 14th, 2023 [December 14th, 2023]
- Electric eel zaps do more than just stun they can alter the DNA of their victims, study suggests - Salon - December 14th, 2023 [December 14th, 2023]
- Blueface Says He Took a DNA Test That Proves He's Not the Father of Chrisean Rock's Son: 'Thank You Jesus' - Complex - December 14th, 2023 [December 14th, 2023]
- Altina Wildlife Park to use DNA tests to find mystery father of black-and-white ruffed lemur triplets - ABC News - December 14th, 2023 [December 14th, 2023]
- In the Shadow of Rome: Ancient DNA Recasts Balkan History - SciTechDaily - December 14th, 2023 [December 14th, 2023]
- Even microbes felt the impact of ancient climate transitions, McMaster DNA researchers find - Brighter World - December 14th, 2023 [December 14th, 2023]
- Clarence 'Red' Wilson cold case murder: DNA helps Montgomery County detective break 37-year unsolved Texas homicide - KTRK-TV - December 14th, 2023 [December 14th, 2023]
- How Construction Companies Can Make Diversity Part of Their DNA - For Construction Pros - December 14th, 2023 [December 14th, 2023]
- DNA analysis of bat droppings shows astonishingly high number of insect species - Phys.org - December 14th, 2023 [December 14th, 2023]
- Co-Lin football's blue-collar DNA on display in huge road win at Gulf ... - Dailyleader - October 13th, 2023 [October 13th, 2023]
- DNA methylation: The hidden mechanism enabling plants to adapt ... - EurekAlert - October 13th, 2023 [October 13th, 2023]
- Neanderthals carried genes acquired from ancient interactions with ... - Penn Today - October 13th, 2023 [October 13th, 2023]
- DNA meythlation clocks and their limitations - Lifespan.io News - October 13th, 2023 [October 13th, 2023]
- Neanderthal DNA may shape how sensitive you are to pain, genetic ... - Livescience.com - October 13th, 2023 [October 13th, 2023]
- OvaPrint a cell-free DNA methylation liquid biopsy for the risk ... - Cancer Discovery - October 13th, 2023 [October 13th, 2023]
- After being freed once, Ohio man languishes on death row - Ohio Capital Journal - October 13th, 2023 [October 13th, 2023]
- Maximizing ROI With Cattle DNA Testing - AG INFORMATION ... - AGInfo Ag Information Network - October 13th, 2023 [October 13th, 2023]
- Pittsburgh's Opening Night Roster Stays True to Its DNA | Pittsburgh ... - NHL.com - October 13th, 2023 [October 13th, 2023]
- Indonesia turns to DNA technology to save their sharks - Earth.com - October 13th, 2023 [October 13th, 2023]
- There are 750 unidentified human remains in Australia. Could your ... - The Conversation - October 13th, 2023 [October 13th, 2023]
- Baltimore Witness - Baltimore Witness - October 13th, 2023 [October 13th, 2023]
- DNA Chips: The Billion Gigabyte Storage Solution of Tomorrow - SciTechDaily - September 9th, 2023 [September 9th, 2023]
- DNA's 'topography' influences where cancer-causing mutations appear - Livescience.com - September 9th, 2023 [September 9th, 2023]
- Dog diversity unveiled by international DNA database - Science Daily - September 9th, 2023 [September 9th, 2023]
- DNA from UW student attack 'one in one quadrillion' match to suspect - The Capital Times - September 9th, 2023 [September 9th, 2023]
- Invitation: TAG Heuer popup to showcase its DNA and motorsports - - Deployant - September 9th, 2023 [September 9th, 2023]
- Ancient Clostridium DNA and variants of tetanus neurotoxins ... - Nature.com - September 9th, 2023 [September 9th, 2023]
- DNA methylation and the opposing NMDAR dysfunction in ... - Nature.com - September 9th, 2023 [September 9th, 2023]
- 'I don't think it's in her DNA': Man who co-authored Murdaugh book with Colleton Co. Clerk of Court discusses allegations - ABC NEWS 4 - September 9th, 2023 [September 9th, 2023]
- Using DNA to solve a family mystery: 'It brought great comfort to ... - The Irish Times - September 9th, 2023 [September 9th, 2023]