Welsh wins 2022 Shaw Prize in Life Sciences and Medicine | Carver College of Medicine – The University of Iowa

Building on these key discoveries, a team of scientists at Vertex, led byNegulescu, initiated research in 1998 into compounds that modulate the function of the CFTR protein. The research led to the development in 2012 of the first compound that corrects the underlying protein defect responsible for disease symptoms. The drug restored cells ability to transport chloride and ushered in a new era of CF treatment, sparking the development of combination-drug therapies.

The combined contributions of Welsh andNegulescu represent the complete biomedical arc from basic discovery to application to the saving of lives, said theShaw Prize in Life Science and Medicine selection committee in announcing the shared award.

Welsh was quick to share the credit for this work.

I am honored to receive this award, which would not have been possible without so many other people who contributed:terrific mentors, talented and creative students and trainees, my tireless and innovative assistants, my cherished colleagues, he says. The support and environment of the University of Iowa made this possible. The Cystic Fibrosis Foundation, National Institutes of Health, Howard Hughes Medical Institute, Carver Trust, and Pappajohn Biomedical Institute provided crucial support along the way. I am deeply grateful.

TheShaw Prizeconsists of three annual awards: the Prize in Astronomy, the Prize in Life Science and Medicine, and the Prize in Mathematical Sciences.The award is managed and administered by The Shaw Prize Foundation, based in Hong Kong.

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Welsh wins 2022 Shaw Prize in Life Sciences and Medicine | Carver College of Medicine - The University of Iowa