Folk Medicine Discovery Could Lead to Better Heart Attack Outcomes – The Roanoke Star

Posted: May 3, 2022 at 9:43 pm

University of Virginia School of Medicine scientists have identified a potential way to improve heart function after heart attacks and it could involve a drug extracted from plants commonly used in folk medicine.

The researchers, led byMatthew J. Wolf, MD, PhD, found that blocking a particular enzyme after heart attacks helped repair damage to the organ in lab mice. The research team did this by using a drug called harmine, which is found in certain plants, including Syrian rue, which has long been used for medicinal and ritual purposes.

Thats not to say that people should take harmine after heart attacksmuch more study is needed. But the researchers believe the underlying approach of blocking the enzyme offers a promising avenue for improving patient outcomes.

Our findings show that investigating the signals controlling normal heart growth can lead to new therapeutic targets to unlock cardiac regeneration, said Wolf, the co-director of UVA Healths cardiovascular genetics program. We hope our research can identify new adjuvant medications that can be added to standard care when someone has a heart attack. Our goals are to help improve heart function and reduce the chances of developing heart failure.

Undoing the Damage From Heart Attacks

The new finding emerges from efforts to prompt the body to replace damaged cells responsible for causing the heart to contract. In adults, the body rarely replaces these specialized cells, called cardiomyocytes. So scientists have been seeking ways to lift the natural brakes that prevent our bodies from manufacturing more of them.

The UVA researchers sought to do this by blocking an important enzyme, or kinase, calledDYRK1a. They took two approaches to this: In one, they shut down the gene activity responsible for producing the enzyme. In the other, they gave lab mice the drug harmine, which inhibits the function of the enzyme.

Both approaches had the desired result in mice, spurring the production of cardiomyocytes and improving the function of the hearts left ventricle. That suggests that doctors may be able to targetDYRK1a, either with harmine or by some other means, to improve patients outcomes after heart attacks. (Harmine, the researchers note, could have effects on multiple organs and, if given for too long, might cause cancer by fostering uncontrolled cell growth. So the scientists suggest additional research into alternatives to inhibit DYRK1a.)

Enhancing adult cardiomyocyte cell cycling after an injury is an attractive strategy to improve heart function after myocardial infarction. Therefore, we analyzed genes during normal heart development when cardiomyocytes stop dividing. The approach led to the hypothesis that DYRK1a kinase might serve as one potential signal controlling cardiomyocyte cycling and heart regeneration, Wolf said. We then used sophisticated transgenic mice we previously created to label cycling cardiomyocytes. We observed that harmine, an inhibitor of DYRK1a, increased myocyte cycling and improved heart function after myocardial infarctions [heart attacks].

Next, the scientists created mice to remove DYRK1a from cardiomyocytes. They found that the cells had increased expression of key genes and improved heart function after injury.

We are excited that our research will lead to new ways to enhance the treatment of cardiovascular disease,said Wolf, of UVAs Division of Cardiology and the Robert M. Berne Cardiovascular Research Center.

Findings Published

The researchers havepublished their findings in the scientific journal Circulation Research. The research team consisted ofAlexander Young, Leigh A. Bradley, Elizabeth Farrar, Helen O. Bilcheck, Svyatoslav Tkachenko, Jeffrey J. Saucerman, Stefan Bekiranov and Wolf.

The work was funded bythe National Institutes of Healths National Heart, Lung, And Blood Institute, grant R01HL158718, and bythe UVA Center of Excellence in Cardiovascular Genetics.

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Folk Medicine Discovery Could Lead to Better Heart Attack Outcomes - The Roanoke Star

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