Monthly Archives: January 2021

Gaucher Disease Treatment Market Shows Expected Trend to Guide from 2020-2026 with Growth Analysis | Genzyme Corporation, Pfizer, Inc., Shire Human…

Posted: January 13, 2021 at 4:37 pm

This Global Gaucher Disease Treatment Market report has been formulated by considering an ever-increasing demand and the value of market research for the success of different business sectors. This market report comprises many work areas of the Healthcare industry. It is not only professional but also is comprehensive which focuses on primary and secondary drivers, market share, competitor analysis, leading segments and geographical analysis.

The size of the global Gaucher Disease Treatment Market is expected to grow in the forecast period from 2020 to 2027, with a CAGR of XX. x% over the forecast period from 2020 to 2027 and is expected to reach XXX. X million by 2027, starting at XXX. X million in 2019.

Gaucher disease is an autosomal recessive inherited metabolism disorder where a type of fat (lipid) called glucocerebroside is unable to degrade. Body synthesis enzyme called glucocerebrosidase, which breakdowns and reprocesses glucocerebroside. Gaucher disease is caused by mutations of a single gene called GBA, which leads to very low levels of glucocerebrosidase enzyme leading to low degradation of glucocerebroside. There are three types of Gaucher disease namely: type 1, type 2, and type 3. Type 1 is the most common type of Gaucher disease while Type 2 and 3 are not as common as type 1.

Global Gaucher Disease Treatment Market competition by Top Key Players: Genzyme Corporation, Pfizer, Inc., Shire Human Genetics Therapies, Inc., and Actelion Pharmaceuticals Ltd. (acquired by Johnson & Johnson in June 2017). There are various drugs in pipeline of companies such as Lixte Biotechnology Holdings Inc, JCR Pharmaceuticals Co Ltd, Pharming Group NV and Orphazyme ApS, for Gaucher disease treatment.

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Segmentation:

The report has been separated into separate categories, such as product type, application, end-user, and region. Each segment is evaluated based on the CAGR, share and growth potential. In the regional analysis, the report highlights the prospective region, which should generate opportunities in the global Gaucher Disease Treatment market in the years to come. This segmented analysis will surely prove to be a useful tool for readers, stakeholders and market participants to get a full picture of the Gaucher Disease Treatment global market and its growth potential in the years to come.

Analysis Of The Competitive Landscape:

The competitive landscape is an essential aspect that all key players must know. The report highlights the competitive scenario of the Gaucher Disease Treatment global market for competing nationally and globally. Market experts also presented an overview of all major players in the global Gaucher Disease Treatment market, taking into account key aspects such as the areas of operation, production and the product portfolio. In addition, the companies in the report are studied based on key factors such as company size, market share, market growth, revenues, production volume and profits.

Market Scope

The Global Gaucher Disease Treatment Market Analysis to 2027 is a specialized and in-depth study of theHealthcare industry with a special focus on the global market trend analysis. The report aims to provide an overview of the Gaucher Disease Treatment market with detailed market segmentation by component, product, application, and geography. The global Gaucher Disease Treatment market is expected to witness high growth during the forecast period. The report provides key statistics on the market status of the leading Gaucher Disease Treatment market players and offers key trends and opportunities in the market.

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Promising Regions & Countries Mentioned In The Gaucher Disease Treatment Market Report:

Table of Content (TOC):

Chapter 1 Introduction and Overview

Chapter 2 Industry Cost Structure and Economic Impact

Chapter 3 Rising Trends and New Technologies with Major key players

Chapter 4 Global Gaucher Disease Treatment Market Analysis, Trends, Growth Factor

Chapter 5 Gaucher Disease Treatment Market Application and Business with Potential Analysis

Chapter 6 Global Gaucher Disease Treatment Market Segment, Type, Application

Chapter 7 Global Gaucher Disease Treatment Market Analysis (by Application, Type, End-User)

Chapter 8 Major Key Vendors Analysis of Gaucher Disease Treatment Market

Chapter 9 Development Trend of Analysis

Chapter 10 Conclusion

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Also, Research Report Examines:

Competitive companies and manufacturers in the global marketBy Product Type, Applications & Growth FactorsIndustry Status and Outlook for Major Applications / End Users / Usage Area

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Gaucher Disease Treatment Market Shows Expected Trend to Guide from 2020-2026 with Growth Analysis | Genzyme Corporation, Pfizer, Inc., Shire Human...

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Best from science journals: Why are platypus so weird? – The Hindu

Posted: at 4:37 pm

Here are some of the most interesting research papers to have appeared in top science journals last week.

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Published in Nature

Australias duck-billed platypus are the perfect example of weird - they lay eggs, nurse their young ones, are toothless with webbed feet, and most interestingly, have 10 sex chromosomes.

Belonging to an ancient group of mammals called monotremes, platypus have always confused scientists. Now, by mapping the complete genome of the mammal, researchers have answered a few questions about the species. The team explains that they are a mixture of mammals, birds and reptiles and have preserved many of their ancestors original features which help in adapting to the environment they live in.

Published in Nature Plants

One particular type of rice plant grown in Zhejiang,China was found to be resistant to the plant pathogen Burkholderia plantarii. But how and why? Researchers who studied the seed of the plant found that a bacteria called Sphingomonas meloni that lived inside the seed helped the plant gain this resistance. The bacteria produce an acid called anthranilic acid which inhibits the pathogen thus saving the crop.

Published in Nature Methods

Minion device. Credit: https://nanoporetech.com/

Weighing just 450gm and measuring 14cm, Oxford Nanopore Technologies MinION device has helped sequence DNA on the go. Now, using special molecular tags, a team from the University of British Columbia has reduced the error rate to less than 0.005%. A beautiful thing about this method is that it is applicable to any gene of interest that can be amplified...it can be very useful in any field where the combination of high-accuracy and long-range genomic information is valuable, such as cancer research, human genetics and microbiome science," writes Ryan Ziels, one of the authors of the study, in a release.

Published in Nature Climate Change

By the late 21st century, the population facing extreme droughts could more than double - from 3% ( from 1976 to 2005) to 8% by 2099. The team notes that this could heighten human migration and conflict. The paper, based on 27 global climate-hydrological model simulations spanning 125 years, also stresses the urgent need for water resources management.

Published in Cell Host & Microbe

Phytoplankton bloom in the Arabian Gulf, Credit: Jeff Schmaltz, MODIS Rapid Response Team, NASA/GSFC.

Researchers have now found that viruses play an important role in microalgae evolution by whole-genome sequencing 107 different species of microalgae from different ecosystems. They compared the genomes of salt-water (marine) and fresh-water microalgae and found that the marine species contained more viral-origin genes. Sequences from Chlorovirus, Coccolithovirus, Pandoravirus, Marseillevirus, Tupanvirus, and other viruses were found integrated into the genomes of algal from marine environments, notes the paper.

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Best from science journals: Why are platypus so weird? - The Hindu

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Developmental Biologist Kathryn Anderson Dies at 68 – The Scientist

Posted: at 4:37 pm

Kathryn Anderson, a developmental biologist at the Memorial Sloan Kettering Cancer Center known for her work detailing the genetics of early embryogenesis, died November 30 at age 68.

Throughout her scientific career, Anderson used rigorous genetic screening assays to identify mutations suspected of disrupting cell division and differentiation in model systems. Having identified a gene of interest, she would then turn to a technique known as forward genetics, creating model organisms such as fruit flies and mice with a particular phenotype to better understand its molecular underpinnings. Using these tools, Anderson made important contributions to scientists understanding of several genetic pathwaysmost notably the Toll and Hedgehog pathwaysrequired for proper development of these animals.

Kathryn was fearless and very open-minded, Tatiana Omelchenko, a senior research scientist in Andersons lab who uses confocal microscopy to do live imaging of mouse embryos, tells The Scientist. Every lab has its own environment and its own mood, and when you stepped into Kathryns lab, you immediately felt very focused.

Born in La Jolla, California, in 1952, Anderson became interested in science at a young age, stemming back to an article in LIFEthat included a detailed image of a human fetus, according to an interview released shortly after her death. She attended the University of California, Berkeley, where she earned her undergraduate degree in biochemistry before heading to a graduate program in neurodevelopment at Stanford University in 1973.

Anderson left that program after only two years, earning a masters degree in neuroscience, and spent the next several years looking for her scientific niche. She enrolled briefly in medical school at the University of California, San Diego, an experience that led her to realize her love of basic research. The clinical work wasnt my cup of tea, Anderson shared in a 2005 biography. The lab was where I felt most at home.

Ultimately, Anderson landed at the University of California, Los Angeles, studying the developmental genetics of Drosophilaunder the guidance of biologist Judith Lengyel. For her PhD work, Anderson showed that in the first two hours after fertilization, the development of Drosophilaembryos remains under maternal control, with maternal RNA and proteins directing cell division and differentiation within the egg.

Looking to further her study of fruit flies, Anderson next traveled to the Max Planck Institute for Developmental Biology in Germany as a postdoc to work with Drosophilageneticist Christiane Nsslein-Volhard. In 1995, Nsslein-Volhard would share a Nobel Prize for her work using mass screenings to identify mutations that disrupt embryonic development, and Anderson would continue studying a handful of the genes identified in these early screens throughout her career.

One such gene, known as Toll, turned out to play an important role in dorsal-ventral (D-V) differentiationdictating, as Anderson said in her biography, how a fly embryo knows its back from its belly. In addition to probing the function of Toll,Anderson continued building out the wider Toll pathway after returning to the University of California, Berkeley, as an assistant professor in 1985, and later in her own lab at the Sloan Kettering Institute, which she launched in 1996 at Memorial Sloan Kettering. During this time, Anderson and her team identified roughly a dozen genes involved in cell differentiation along the D-V axis, and she used similar screening methods to better understand Tolls role in innate immunity of Drosophila. Her findings were noted by geneticists Jules Hoffmann and Bruce Beutler, whose study of Toll-like receptors in both fruit fly and mammalian immunity would later earn them a Nobel Prize.

Kathryn Anderson

Memorial Sloan Kettering Cancer Center

After her successes in fruit flies, Anderson began thinking about applying her same methods to the study of mice. She spent a year on sabbatical in the lab of Rosa Beddington at the National Institute for Medical Research in the UK, where she showed that Toll had no analogous role in the D-V differentiation of mammals. It demonstrated, she said in a 2016 interview with Development, that there are things about early mammalian development that you cant figure out by extrapolating from flies.

Back at the Sloan Kettering Institute, Anderson began once again using mass genetic screenings, this time to identify mutations of interest in mice, and then studying them in fine detail. These were lengthy experiments that often took years to yield results. I think her major contribution is discovering the functions and roles of genes through this mutagenesis screen, Omelchenko says. This is amazing because . . . the mouse embryo model is quite complex, but she did the work.

Anderson and her team screened more than 12,000 mutations, selecting roughly 40 that produce obvious phenotypic disruptions midway through gestation. Working diligently over many years, Anderson identified previously unknown pathways that have since prompted new research directions in the field of developmental biology.

Through her screening, for example, Anderson identified a previously unknown relationship between ciliamicroscopic, hairlike structures on the outside of some cellsand proper signaling of the Hedgehog pathway that dictates cell differentiation in mammalian embryos. Further research showed that components of this pathway are enriched in cilia, while mice with certain mutations in genes involved in Hedgehog signaling lacked cilia altogether in a structure called the node that directs gastrulation in vertebrate embryos. That turned out to be pretty amazing, actually: theres this whole organelle required for Hedgehog signaling in vertebrates, but not in flies, Anderson said in her Developmentinterview. Its a geneticists dream, but raises the question of why organize the genome like this: there are so many weak points in Hedgehog signalingand Hedgehog is so vital.

For her contributions to the field of developmental biology, Anderson was inducted into the National Academy of Sciences in 2002 and elected as a member of the Institute of Medicine of the National Academies in 2008. In addition, she was awarded the Thomas Hunt Morgan Medal for lifetime contributions to the science of genetics in 2012, the Federation of American Societies for Experimental Biologys Excellence in Science Award in 2014, and the Society for Developmental Biologys Edwin G. Conklin Medal for distinguished and sustained research in 2016, among other honors.

Prior to her death, Anderson had spoken about the possible extension of her research into human genetics, as disruptions in hedgehog signaling have since been linked both to birth defects and to a series of diseases referred to as ciliopathies. It was, however, a line of questioning she planned to leave to other scientists, content to continue her methodical work exploring mutations in mice.

Many scientists are very quiet people, but contemporary society requires you to be very loud [so] that people will listen to you, Omelchenko says. Kathryn is such a great example of being quiet, being a very deep thinker, and at the same time becoming a very successful and bright scientist. I think I will keep learning from her even though she has passed away.

Anderson is survived by her husband, Timothy Bestor, a geneticist at Columbia University.

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Darwinism as the Root Problem of Modernity – Discovery Institute

Posted: at 4:36 pm

Photo: G. K. Chesterton, via Wikimedia Commons.

Editors note: The following, second in a three-part series, is adapted from an essay inNational Reviewand is republished here with permission. ProfessorAeschlimanis the author ofThe Restoration of Man: C.S. Lewis and the Continuing Case Against Scientism(Discovery Institute Press). Find the full series here.

Oscar Wilde (18541900), a witty Dublin Protestant-atheist Irishman like GeorgeBernardShaw, but of a very different class, stamp, and implication, wrote that natural science, by revealing to us the absolute mechanism of all action, [frees] us from the self-imposed and trammeling burden of moral responsibility. Wildes resultant, post-Christian aesthetic immoralism shocked and mocked the earnestness of late Victorian Britain in witty prose and plays, including the satirical wit (and homosexual implication) ofThe Importance of Being Earnest(1895). Both Shaw and G. K. Chesterton had an intimation that Wildes witty persiflage actually disguised deep decadence, an argument made brilliantly several decades later by the American Jewish moralists Philip Rieff (The Impossible Culture: Wilde as a Modern Prophet, 198283, reprinted inThe Feeling Intellect, 1990) and Daniel Bell (The Cultural Contradictions of Capitalism, 1976; Beyond Modernism, Beyond Self, 1977). From Wilde came the Bloomsbury aesthetes and, we may say, nearly the whole world of the modern arts.

Yet both Shaw and Chesterton were themselves noted wits (both sometimes even accused of being paradox-mongering buffoons), and in fact Shaw shared much of the iconoclasm of his countryman Wilde, becoming a self-described feminist, Nietzschean, Ibsenite, and Wagnerite. But for Chesterton one of Shaws great achievements was his deep, abiding hatred of aestheticism Shaw even insisted that the Puritan evangelist John Bunyan (The Pilgrims Progress) was a greater writer than Shakespeare, and frequently, unaccountably, made orthodox statements, such as There is a soul hidden in every dogma and Conscience is the most powerful of the instincts, and the love of God the most powerful of all passions. Along with T. S. EliotsMurder in the Cathedral(1935) and Robert BoltsA Man for All Seasons(1960), Shaws playSt. Joan(1924) is one of the wisest, wittiest, and most sympathetic dramatic depictions of Christian religious belief in the last hundred years.

Both Shaw and Chesterton believed that the root problem of modernity was Darwinism, the acceptance of which made it impossible to resist its moral corollary, social Darwinism, and therefore plutocracy, amoral capitalism, imperialism, racialism, and militarism. Shaw wrote in the preface toMan and Superman(1903): If the wicked flourish and the fittest survive, Nature must be the god of rascals.

Though Shaw was a small-p protestant religious heretic (he argued that Joan of Arc was an early Protestant, like Hus and Wycliffe), Chesterton asserted that he was a true if eccentric Puritan moralist. Shaws critique of Darwinism was profound, especially in the long preface to his mammoth playBack to Methuselah(1921): The literary critic R. C. Churchill has called this preface the wittiest summary of the Darwinian controversy ever written (see especially the sections from Three Blind Mice onward). In his own 1944 postscript to the play, Shaw, while still insisting on the need to give up the Protestant creed (and all other Jewish and Christian creeds) of his youth in the Anglo-Irish Ascendancy in Dublin, held that Darwins exclusion of mind and purpose from nature was wrong and destructive: Unless we can reclaim mind, will, and purpose as realities in some kind of non-Darwinian, creative evolution, we fall into the bottomless pit of an utterly discouraging pessimism.

Shaws predecessor Samuel Butler (18351902), and his Franco-American successor and admirer Jacques Barzun (19072012), have made similar arguments, arguments given renewed strength more recently by the American philosopher Thomas Nagel (see my Rationality vs. Darwinism,National Review, 2012). Shaws resistance to determinism, and his insistence on the irreducible reality of human consciousness and will in nature and history, elicited Chestertons profound respect and admiration. In his final, 1935 chapter on Shaw, written in the last year of Chestertons own life, he said of the older mans achievements in drama over the previous 40 years: He has improved philosophic discussions by making them more popular. But he has also improved popular amusements by making them more philosophic. He added that Shaw was one of the most genial and generous men in the world.

Yet Chestertons admiration and approval were shadowed by a sense that Shaw had great deficiencies and that his influence was ambiguous and in some cases malignant. Born 18 years earlier than Chesterton, Shaw outlived him by another 16, his life encompassing both world wars, unprecedented destruction, and the fundamental disproof of his early progressivism and cosmopolitanism. His early Fabian socialism led him to become an influential communist fellow traveler. The famously exuberant, energetic Shaw told his biographer Hesketh Pearson, a close friend of Malcolm Muggeridge, that, in the postWorld War II world, he wished when he went to bed that he would never wake again.

Like H. G. Wells, he was threatened with an utterly discouraging pessimism when his political hopes came to seem almost completely vain. Commenting on the significance of Aldous Huxleys satirical dystopiaBrave New World(1932), even before George Orwells1984, an English writer quoted by Chesterton in his 1935 chapter said, Progress is dead; andBrave New Worldis its epitaph. Beyond the world of fiction, in the world of actual human tragedy, works such as Elie WieselsNightand SolzhenitsynsGulag Archipelagomay be said to have proved the point unanswerably: Human progress may be possible, based on willed choices, but there is certainly no mystical, progressive, propulsive purpose immanent within history.

Chestertons argument about Shaw from the beginning was that he was in three ways an outsider, ways that gave him a unique perspective and insight but that also prevented his understanding what Chesterton thought of as a fundamental piety that had been characteristic of Western civilization and Western societies at their best: Shaw was a Protestant Anglo-Irishman who disdained his own country and left it permanently for London; he was emotionally, intellectually, and politically a fastidious Puritan moralist who could not, however, believe any longer in the Puritan God; and he was a Nietzschean-socialist futurist whose disgust with the human past and its traditions made him an ultimate outsider to any particular historical community or continuity.

Free from what Chesterton called the vile aesthetic philosophy of his also-cosmopolitan Irish countryman Wilde, a philosophy of ease, of acceptance, and luxurious illusion, Shaw read and was deeply affected by Nietzsche after having committed himself, in mind, action, and loyalty, to the Fabian-socialist cause, making lifelong friends and allies of Sidney and Beatrice Webb, whom he was instrumental in getting buried with full honors in Westminster Abbey in 1947. But reconciling Nietzsche with socialism was a lifelong conundrum, and it should be no surprise that Shaw came to admire strong men beyond the bourgeois-democratic tradition and temper such as Mussolini, Stalin, and the British fascist Sir Oswald Mosley. Stalin has delivered the goods, the celebrity Shaw wrote in 1931, the year of his state-conducted tour of Russia with his friend Lady Astor. A photo of the two of them in a chauffeured car on Red Square in Moscow is on the cover of David Cautes indispensable bookThe Fellow Travellers: A Postscript to the Enlightenment(1973), a brilliant documentation of the lamentable credulity of Western intellectuals in confronting Lenin, Stalin, and what the Webbs called the new civilization of the Soviet Union. Shaw died in his English country house in 1950 with a signed photograph of Stalin on his mantelpiece.

Chestertons brief study of 1909 and its even briefer 1935 sequel were thus profoundly apt in assessing Shaws greatness and his folly. He saw that Shaw was really no democrat, that his admirable public spirit had in it something cold, abstract, theoretical, and even Platonist in the sense of Plato as an elitist authoritarian; whereas Chesterton himself was truly a kind of democrat, actually liking the common man and assuming that human beings across time had come to certain conventions, traditions, and sentiments that usually had in them some important truth. (This idea profoundly influenced the Chestertonian William F. Buckley Jr.)

Tomorrow, Shaw, Scientism, and Darwinism.

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Vedantic Humanism For Post-Darwin Humanity Through The Eyes Of Swami Vivekananda – Swarajya

Posted: at 4:36 pm

When Swami Vivekananda uttered, Sisters and Brothers of America" at the World Parliament of Religions at Chicago in 1893, they declared Vedantic humanism to the world.

Vedantic humanism is fundamentally different from the humanist philosophies of the West in the sense that it is based on the fundamental unity of all existence which is also manifested in the oneness of humanity.

The West was then still struggling to come to terms with the idea of common unity of humanity. The discovery of humanity being but one branch in the grand tree of life as revealed by Charles Darwin, had yet again removed man, especially the white man, from the centre of the biological universe as well.

The West tried to retain its collective racial ego through Social Darwinism as the answer to biological Darwinism.

Not only the religious fundamentalists who rejected outright evolution but also the philosophers of the West, whether the conservatives or the radicals including the emerging Marxists, who embraced varying degrees of social Darwinism.

They speculated that the less evolved state of the non-European races justified colonialism which either eliminates or elevates the 'lower races' through a very slow process of 'civilising' that happens, of course, under colonisation.

Even Marx and Engels basically advocated such a process.

Here, it should be stated that Charles Darwin himself was not very comfortable with the idea of social Darwinism. After Darwin, many leading social philosophers of the West, as well as those influenced by the West embraced Social Darwinism eagerly.

Swami Vivekananda is refreshingly different. Long before intelligent design (ID) became the camouflage for creationism, Vivekananda refuted the ID argument. With Sankhya Darshana he knocked down the concept of creator:

In a scathing attack on design and creator that actually anticipates Dawkins, Vivekananda states:

Lest anyone rushes to map priest craft to Brahmins because of the colonial-evangelical negative stereotypes, Swami Vivekananda warns:

Then with Yoga and Advaita he could check Darwinism becoming Social Darwinism.

For him, the modern research will make "the evolution theory of the ancient Yogis better understood", the yogic conception of evolution provides "a better explanation. He correctly cautions that "sexual selection and survival of the fittest", which are terms used by evolutionists when taken into human realm could "furnish every oppressor with an argument to calm the qualms of conscience.

In his explanation of the Yoga aphorisms of Patanjali, he contrasts the flawed social Darwinism with the inner evolution that Patanjali brings out:

To him "there is no reason to believe that competition is necessary to progress" rather "when knowledge breaks these bars, the god becomes manifest" as becoming god is the next step for humans.

Interestingly, in the writings of Swami Vivekananda conceptually (filling in as the cause of speciation) and more explicitly in Sri Aurobindo, a kind of premonition of punctuated equilibrium sudden bursts rather than gradualism in evolution.

The Western society, post-Darwin and till Holocaust, was drunk to saturation with the idea of eugenics and social-Darwinism. Those who were labelled invalids and hereditary criminals were barred from marriages and jailed. Sometimes they were forcefully made sterile. All these practices were justified in the name of science.

In India, the colonial government enacted the 'Criminal Tribes Acts' and branded entire communities as criminals based on birth. However, Swami Vivekananda rose against this tide and declared that human evolution is based on qualitatively different process.

It was only after the Nazi Holocaust and the horrors of mass killing of mentally challenged and physically challenged populations as well as elimination of the ethnic groups labelled as 'inferior' by Nazi State machine that the Western thinkers realised the immense folly of their upholding of social Darwinism.

As against these there have been voices in isolated isles of the West which spoke against social Darwinism, and interestingly invariably these voices had a Vedantic connection.

One such example is Pyotr Kropotkin. Kropotkin emphasised that not struggle but mutual cooperation is a strong process that shapes evolution.

His book Mutual Aid a Factor in Evolution was published in 1902. In 1900, he met Swami Vivekananda at Paris. Author P Mukherjee writes: "The core of these meetings, I would like to believe (and believe) is to explore the distinctiveness of different shades of opinion, however, diverse they are or they might look to be."

Swami Vivekananda's observation, that the evolution of non-human organic life and human evolution making an organically united yet a qualitatively different process is accepted by evolutionists today.

Even die-hard neo-Darwinian like Richard Dawkins speaks of human evolution as governed by memes and extended phenotypes unlike the other organisms where genes and selection pressures alone determine evolution.

This is a collective evolution. System biologists like V I Vernadsky speak of transition from biosphere to noosphere. Sri Aurobindo took forward the vision of Swami Vivekananda and spoke of supra-mental consciousness descending on the planet.

And this vision never favoured any specific race or culture but entire humanity. Both Sri Aurobindo and Swami Vivekananda recognised that all humanity owes its evolution to all humanity. In fact, Swami Vivekananda, rejecting the Aryan race theory, sharply reacted to those who spoke high of their 'Aryan' superiority or Aryans civilising the world thus:

So, what Swami Vivekananda set in motion on September 11 at Chicago is the continuing declaration of Vedantic humanist ideal which manifests itself when humanity liberates itself from the shackles of all artificial barriers it has built around it and realises that it is part of the great cosmic divinity that permeates and animates all existence.

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Vedantic Humanism For Post-Darwin Humanity Through The Eyes Of Swami Vivekananda - Swarajya

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‘Mandalorian’ Star Gina Carano Takes Us Behind The Scenes, Explains Her Politics – The Federalist

Posted: at 4:30 pm

On this episode of The Federalist Radio Hour, former MMA fighter and The Mandalorian star Gina Carano joins host Ben Domenech to discuss her role in the Star Wars series and explain how she approaches ideological diversity and wokeness in Hollywood.

The whole reason I started speaking out is because I feel like there is a large group of people that were being silenced this year and being forced to play this game of wokeism or whatever it is, Carano explained. No matterwho you voted for, no matter who you are, I want to create a platform where everybody can have an opportunity. Everybody.

In the interview, Carano also admitted that she hasnt watched the second season of The Mandalorian.

I dont like to watch myself. I feel like I get in my head a little bit, Carano explained. Ill watch it eventually just to see how I can grow from it. The more fascination for me was seeing the other Star Wars fans enjoy it.

With a franchise, I think somebody has to be such a fan, they have to be a big fan of what they are doing, or else I dont think it works as well, Carano said.

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'Mandalorian' Star Gina Carano Takes Us Behind The Scenes, Explains Her Politics - The Federalist

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A Divisive Impeachment Will Only Make Trump A Martyr – The Federalist

Posted: at 4:30 pm

President Donald Trump is on his way to becoming the most cancelled man in America.

On Friday, Twitter pulled the plug on the presidents account in a move that was a long time coming after a horde of Trump supporters rampaged about the U.S. Capitol in protest of the Electoral College certification. The move followed Facebook and Instagram doing the same on Thursday, sparking a leftist purge of online voices dissenting from the dystopian world order of big tech oligarchs ruling from Silicon Valley.

Google, Snapchat, Spotify, Shopify, YouTube, TikTok, Pinterest, Reddit, and Twitch have each now banned or restricted an outgoing president now facing not only corporate banishment from the online public square but a second impeachment by Democrats seeking to bar the outgoing commander-in-chief from ever holding office again. The presidents exile, however, coming from top government officials and big corporate exposes not only the faade of Democrats call for unity but a deep obliviousness to the underlying issues that sparked the Capitol unrest.

Below is one of the final posts retweeted by Ashli Babbitt, the 35-year-old woman who served 14 years in the military and was shot to death while attacking the Capitol building.

People I trust in Washington DC 1) President Trump the end, the post reads.

While video of Babbitts shooting calls into question the officers use of a deadly weapon, her presence at the Capitol cant be excused. Nor could any other persons. Americans were killed in the attack, dozens others were injured. The imagery of a riotous mob overwhelming the Capitol put another scar on a fractured country.

Condemning the rioters and understanding their presence, however, are not mutually exclusive. Each are equally important.

Babbitts endorsement of the post above, along with the more than 22,000 others who liked it, is emblematic of the worldview shared by millions as institutional leaders have failed them, lied to them, and even mocked them for decades.

As my colleague, Federalist Culture Editor Emily Jashinsky, points out, while their views of mistrust might be misguided, theyre hard to blame, because the corporate media has lied to them about the big stuff time and time and time again. So have their elected officials. So have scientific institutions and leaders in academia.

Theyve watched their mayors and governors violate their own regulations for the sake of leisure or personal convenience or politics, crippling business and workers while they eat crabs. They then watched the medias nakedly unbalanced coverage of it all, wild bias from bonus-pocketing journalists purporting to be arbiters of fact and undisputed occupants of the moral high ground.

Their lives, like all of our lives, have been upended in just over a decade by products tech oligarchs promised would make us happier. Those same billionaires now join the chorus of elites who treat them as irredeemables and deplorables because they disagree with full-throated progressivism.

So when Trump stood down the street from the Capitol and blasted the election being certified in the Democrats favor as an illegitimate process, his thousands of followers believed him, ransacked the Capitol, and gave leftists ammunition to declare them deplorable.

Last weeks unrest has now been capitalized on by Democrats and their allies in big media and big tech to implement a corporate-government crackdown that was absent in the aftermath of routine riots last year from far-left militants.The onslaught has offered Democrats the political momentum to achieve the top policy item of their Trump-era agenda: the presidents impeachment, even after hes out of office.

Impeachment, however, only serves to inflame divisions by rooting out a man who was always a symptom of deep problems that promise to persist even long after his departure. Worse, Trumps post-presidential impeachment reinforces the convictions of the presidents supporters who believe Trump is the only figure they could trust. Thats what led them to riot in the first place.

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A Divisive Impeachment Will Only Make Trump A Martyr - The Federalist

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Democrat Wants To Put Josh Hawley And Ted Cruz On The No-Fly List – The Federalist

Posted: at 4:30 pm

The Democrat chair of the U.S. House Committee on Homeland Security wants Republican Sen. Ted Cruz and Josh Hawley put on the federal No Fly list due to the actions they participated in when the U.S. Capitol was ransacked by Trump supporters on Jan. 6.

When asked by SiriusXM host Joe Madison whether the no-fly sanction should be applied if Cruz and Hawley are found liable for the capitol unrest, House Homeland Security Committee Chair Rep. Bennie G. Thompson said, Theres no question about it.

Theres no exemption for being put on the no-fly list, said Thompson. Even a member of Congress that commits a crime, you know, theyre expelled from the body. There are ethics charges that can be brought against those individuals. And people are looking at all of this.

Cruz and Hawley did not participate in any violent actions. The senators have both publicly condemned any rioting that occurred on Jan. 6. Democrats are angry because Hawley and Cruz led a legal objectionto counting some Electoral College votes. For wanting to ensure the integrity of U.S.elections, Democrats are callingfor the senators to resign or beremovedfrom office.

Hawley and Cruz have been smeared by the left as violent insurrectionists and threats to our democracy. President-elect Joe Biden last FridaycalledHawley and Cruz Nazis who should be flat beaten the next time they run.

Following the capitol riot, Simon and Schuster said last Thursday that it has canceled the publication of Hawleys upcoming book The Tyranny of Big Tech.

Thompson is leading the charge to punish all the rioters who entered the capitol. First of all, these folks, in my opinion, can be classified as domestic terrorists because of the actions they participated in on Wednesday, said Thompson. Now under normal circumstances international terrorists are out on no-fly lists. These are domestic terroristssame thing. A terrorist is a terrorist, no matter who you are.

Apparently, however, it does matter who you are. The Mississippi representative never characterized the Black Lives Matter and Antifa thugs, who looted and vandalized American cities all summer including the U.S. capitol, resulting in mass chaos, destruction, insurance payouts of up to $2 billion, and the death of at least 30 people, as terrorists. Nor did he rally to have the left-wing rioters placed on the no-fly list. Actually, he publicly supportedthem.

Evita Duffy is an intern at The Federalist and a junior at the University of Chicago, where she studies American History. She loves the Midwest, lumberjack sports, writing, & her family. Follow her on Twitter at @evitaduffy_1

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Andrew Yang Can’t Imagine The Reality New Yorkers Face – The Federalist

Posted: at 4:30 pm

If Andrew Yang wants to be mayor of New York, he needs to live here.

Andrew Yang wants to be the mayor of New York City. Its an attractive job opportunity given that the current mayor, Bill de Blasio, is so awful that anyone in the city over the age of 5 would do a better job than he has. The problem, however, is that Yang is not in the city. Instead, Yang and his family have been residing in the tony Hudson Valley town of New Paltz. He explained why that is to the New York Times, and its a doozy.

We live in a two-bedroom apartment in Manhattan. And so, like, can you imagine trying to have two kids on virtual school in a two-bedroom apartment, and then trying to do work yourself? Yang asked.

Well, yes, Mr. Yang, I can imagine that. In fact, I dont have to imagine it because I am living it. Even as I write this, my son is in his room in my two-bedroom apartment doing virtual school while I work. This has been a reality for millions of New Yorkers for almost a year now. And most of us arent even millionaires. Yang cant imagine it? He cannot conjure in his mind what it is like to live under the current conditions in New York City? And he wants to be my mayor?

Beyond Yangs degree of tone-deafness, his comment also makes New Yorkers question his basic knowledge of Gotham. His two-bedroom in Manhattans Hells Kitchen neighborhood might not be spacious enough for his current needs, but if space is the issue, there is no reason to flee to New Paltz. Someone might want to tell him about the outer boroughs.

Parts of Brooklyn, Queens, and the Bronx have stand-alone homes and breezy backyards. In Staten Island, there are so many deer that the city has a Deer Impact Management Plan. It also has some of the finest pizza in all the land. The point is that if space is Yangs hang-up, New York City offers a ton of options. What New York City does not offer, however, is indoor dining or movies. For those, one must go to a place we refer to as Upstate, which is actually the entirety of the rest of New York.

In a city that produced both de Blasio and Rep. Alexandria Ocasio-Cortez, Yang might wind up being the most rational and reasonable electable candidate, notwithstanding his goofy universal basic income proposals. Former Democratic Rep. Max Rose, something of a moderate who ran ads featuring himself with Donald Trump, has declined to run, leaving the centrist lane open. But this is not a good start for Yang. Telling people you want to govern the city but cant imagine living there sounds like something someone from Jersey would say.

Yang is right though that conditions in Americas largest city right now are pretty horrible. Thats one reason why its losing residents faster than a gun shot victim loses blood and it also has near-record numbers of those. Many of the people leaving are moving to Florida, which is weird since most people in the media think the Sunshine States governor, Ron DeSantis, is the living embodiment of evil.

If Yang wants to reside in Gracie Mansion, he cant hide out in New Paltz while the city suffers. He has to be here with us. He has to be able not just to imagine but to experience the brutal effect that lockdowns are having on our communities.

Andrew Yang has a shot, but he has to step up his game. Be our neighbor, feel our pain, Mr. Yang. You cant lead New York City from New Paltz.

David Marcus is the Federalist's New York Correspondent. Follow him on Twitter, @BlueBoxDave.

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Andrew Yang Can't Imagine The Reality New Yorkers Face - The Federalist

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The Biggest Gun Forum Just Kicked Off The Internet Without Explanation – The Federalist

Posted: at 4:30 pm

AR15.com, the biggest gun forum in the world, was deplatformed on Monday by web hosting company GoDaddy.

ARFCOM IS DOWN. Weve been booted from GoDaddy and are looking for an alternative solution, the site announced Monday afternoon on Twitter.

The swift termination by internet host GoDaddy forced AR15.coms leadership to think on their feet and quickly create a temporary URL so freedom lovers and firearm enthusiasts could continue to access the information and resources on the site.

Instead of offering specifics about kicking the gun site off the internet, GoDaddy merely claimed that AR15.com violated its terms of service, which resulted in instant termination.

On Monday, January 11, 2021, I received notice from our site registrar that AR15.com had violated their terms of service and that AR15.com would be shut down immediately, President and Co-Founder of the gun site Juan Avila told The Federalist in a statement. The registrars decision to de-platform AR15.com was final and no method to appeal was offered.

It remains unclear specifically what content allegedly violated the registrars terms of service, he added.

When asked by The Federalist about the decision to remove AR15.com, GoDaddy claimed that the site both promotes and encourages violence, but did not offer any specific examples. Instead, they offered AR15.com 24 hours to relocate its business.

The decision from GoDaddy follows of series of bans and contract terminations by big tech companies such as Amazon, Google, Apple, Twitter, and Facebook targeting conservatives and supporters of President Donald Trump. In addition to using their acquired power to ban and distance themselves from the president and his supporters, many have also engaged in what some have labeled anti-competitive behavior, encouraging and pushing each other to nuke alternative sites such as Parler.

Despite the abrupt change in AR15.coms site domain and traffic, Avila said that AR15.com already found a new, First Amendment-friendly site registrar that will accommodate the forum during its transition, which may take a few days.

Jordan Davidson is a staff writer at The Federalist. She graduated from Baylor University where she majored in political science and minored in journalism.

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