Monthly Archives: January 2021

The Global Complementary and Alternative Medicine Market research report thoroughly explains each and every aspect related to the Global Complementary and Alternative Medicine Market, which facilitates the reports reader to study and evaluate the upcoming market trend and execute the analytical data to promote the business. The growth trend forecasted on account of thorough examination offers in-depth information regarding the global Complementary and Alternative Medicine Market.

Complementary and Alternative Medicine Market Insight:

Complementary and alternative medicine market is expected to gain market growth in the forecast period of 2020 to 2027. Data Bridge Market Research analyses the market is growing with the healthy CAGR in the above-mentioned research forecast period. Rising prevalence cancer and other serious diseases worldwide and emerging markets are the factors responsible for the growth of this market.

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Leading Complementary and Alternative Medicine Manufacturers/Companies Operating at Both Regional and Global Levels:

Nordic Naturals, Natures Bounty, Unity Woods Yoga Center, Columbia Nutritional, First Natural Brands Ltd., Ayush Ayurveda, Sheng Chang Pharmaceutical Company, Pure Encapsulations, LLC. Quantum-Touch, and Herb Pharm, LLC among others.

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Competitive Analysis:

Complementary and Alternative Medicine market report highlights key players included in the market in order to render a comprehensive view of the competing players existing in the market. The participants are profiled based on factors such as product types manufactured, industry scenario, share distribution in the market, and strategies of competitors.

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This study analyzes the growth of Complementary and Alternative Medicine based on the present, past and futuristic data and will render complete information about the Complementary and Alternative Medicine industry to the market-leading industry players that will guide the direction of the Complementary and Alternative Medicine market through the forecast period. All of these players are analyzed in detail so as to get details concerning their recent announcements and partnerships, product/services, and investment strategies, among others.

Industrial Analysis:

The Complementary and Alternative Medicine market report is extensively categorized into different product types and applications. The study has a separate section for explaining the cost of raw material and the revenue returns that are gained by the players of the market.

The report includes accurately drawn facts and figures, along with graphical representations of vital market data. The research report sheds light on the emerging market segments and significant factors influencing the growth of the industry to help investors capitalize on the existing growth opportunities.

Sales Forecast:

The report contains historical revenue and volume that backing information about the market capacity, and it helps to evaluate conjecture numbers for key areas in the Complementary and Alternative Medicine market. Additionally, it includes a share of each segment of the Complementary and Alternative Medicine market, giving methodical information about types and applications of the market.

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In the end, the Complementary and Alternative Medicine market is analyzed for revenue, sales, price, and gross margin. These points are examined for companies, types, applications, and regions.

To summarize, the global Complementary and Alternative Medicine market report studies the contemporary market to forecast the growth prospects, challenges, opportunities, risks, threats, and the trends observed in the market that can either propel or curtail the growth rate of the industry. The market factors impacting the global sector also include provincial trade policies, international trade disputes, entry barriers, and other regulatory restrictions.

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Complementary and Alternative Medicine Market To Register Phenomenal Growth and Competitive Outlook 2027 - KSU | The Sentinel Newspaper

Sitting on the top tier of a cruise ship in Egypt, Professor Steffanie Strathdee and her husband were enjoying their meal and looking forward to sightseeing on their final day. It had been a dream holiday for Steffanies husband, Tom, to explore Egypt and the pair of researchers had finally made it over in 2015. A few hours after their idyllic dinner, however, Tom suddenly fell terribly ill.

Professor Steffanie Strathdee, an infectious disease epidemiologist, supposed it was from the seafood theyd eaten and didnt think much of it until the next day. Nothing worse than food poisoning ruining your final day on holiday, right? Well, as he became more dehydrated and other symptoms started to crop up, Steffanie began to worry that something worse had disrupted their bliss.

Im not a medical doctor, but I do have a rusty old degree in microbiology. And I was literally calculating incubation periods in my head for different organisms that he could have acquired. When he started complaining of back pain, I realised this isnt food poisoning if hes got back pain. So I called a friend of ours who happened to be the head of infectious diseases in the department we work, says Steffanie.

This friend was Professor Chip Schooley at the University of California, San Diego. He played an essential role in unravelling this mystery illness. From the symptoms described, he urged Steffanie to take Tom to a hospital as soon as possible. Unfortunately, the area of Egypt they were staying in didnt have any hospitals, only a clinic.

[The clinic] was staffed with wonderful Egyptian doctors and they did their best with what limited resources they had, Steffanie says. They did diagnose pancreatitis, an inflammation of the pancreas but they said there would likely be some serious complications that are going to be above what the clinic can handle.

Tom being treated in the clinic in Egypt Steffanie Strathdee

So, Steffanie, her husband and his inflamed pancreas travelled over 3,000km from Egypt to reach a hospital in Germany. Once in the hospital, shewas shocked to learn that her husband had a gallstone obstructing his bile duct that had led to a stomach abscess the size of a small football.

Draining the abscess revealed a putrid fluid. There was something growing in there, the doctor said, and it had been for some time.

Staring down a flask of this murky stomach fluid, Steffanie wasnt too alarmed by the doctors news. She knew that generally these things can be resolved by examining the material that had been growing in the abscess and prescribing the relevant antibiotics. A fairly straightforward problem to tackle. Hell be right as rain in a couple of days, she thought.

Read more about medicine and antibiotics:

Unfortunately, this wasnt the case for Tom. A few days passed and rather than arriving with good news, the doctor returned in head to toe protective medical clothing. Standing aside from Toms bed with a gown, mask and a set of gloves he announced to Steffanie, Ive got some very bad news. This is the worst bacteria on the planet.

What makes a bacteria good or bad in a case like this is how treatable it is. Can we throw penicillin at it and solve everything? Or does it need more tailored antibiotic treatment? If the bacteria causing your illness adapts to dodge the antibiotics trying to clear your body, then it is very bad indeed.

Antibiotic resistant bacteria which persist despite antibiotic treatments can be fatal. This bacteria, Acinetobacter baumannii,may not be familiar to most, but Steffanie recognized it from her undergraduate microbiology degree in the 1980s.

I realised that we used to plate this organism on our petri dishes back then and all we needed was a lab coat and gloves, she says. And he said this is the worst bacteria on the planet. Like, how can this be? Im an infectious disease epidemiologist. This is catching me really off guard.

Tom and Steffanie Steffanie Strathdee

Native to soil and water bodies across the world, Acinetobacter baumanniiwas considered to be sensitive to most antibiotics in the 1970s and 80s. However, today it shows wide-ranging resistance to several antibiotics and is regarded as a superbug. This bacteriacolonises the body, specifically targeting moist tissue and causing necrosis (tissue cell death) before entering the blood stream.

Steffanie investigated and learned how the bacteria rapidly develops resistance through genetic mutations, eschewing treatment. Its something of a bacterial kleptomaniac. Its really good at stealing antibiotic resistant genes from other bacteria, says Steffanie. Though concerned, she knew the doctors would try the options available to defeat the superbug and improve Toms condition.

The doctors in Germany tried a range of antibiotic treatments for Tom. While the Acinetobacter baumanniifestered and developed, these treatments effectively wiped out his immune system and allowed the superbug to spread.

Steffanie says that while in Germany, the superbug was resistant to 15 of the antibiotics they tried and was only partially sensitive to three. However, all of these three had severe side effects and is used as a last resort antibiotic. They decided it was time to move Tom home to San Diego, taking care to follow infection control procedure to prevent his condition from declining.

By the time they arrived back in San Diego, Toms superbug had become resistant to these last three antibiotics. At this point, Steffanie relied on her colleagues and the doctors for the best course of treatment. He was at risk of septic shock, a potentially fatal condition in which your blood pressure plummets to a dangerously low level. So, the doctors in San Diego tried to siphon the infected fluid from his abscess as Tom was too weak for surgery. Yet, the day before they were supposed to leave hospital, the superbug spread further.

He had five different drains as well as a feeding tube, he looked like a pincushion. One of those internal drains slipped and it poured all that infected fluid into his abdomen, into his bloodstream, recalls Steffanie.

Tom being treated in San Diego hospital Steffanie Strathdee

This spillage resulted in what doctors had been dreading. Tom went into septic shock.

Your body is kind of over reacting to an invader that hits the bloodstream. And right away, the heart rate increases, the blood pressure drops, the person flushes, develops a fever and starts panting and usually they start to shake. This shaking is called rigors and its so intense that, in Toms case, the bed frame hit the wall. And this is all within like the span of two minutes, so I was pretty stunned, says Steffanie.

He was rushed to intensive care where doctors put him on a ventilator. Steffanie had thought she would be taking her husband home the following day, but instead Tom ended up in a medically induced coma. After reaching his bloodstream, the superbug fully colonised Toms body.

At this point, with no antibiotics left, Steffanie began to investigate further, researching the superbug and alternative treatment possibilities. Reflecting on this now she says, it hadnt really sunk in that I might never be able to hear my husband speak again. We may never be able to communicate.

There was nothing else the doctors could do and little by little he was wasting away. After some time, he was not in a medically induced coma. He was in a coma that he wasnt really waking up from. Some days his eyebrows would kind of wiggle or his fingers would try to reach out, she says.

With Toms lungs failing, medications keeping his heart pumping and doctors suggesting he needed kidney dialysis, Steffanie knew it was close to the end. Sitting by his bedside, she asked if he wants her to keep fighting for him.

I know that youre fighting really hard and youre tired. And if you want to let go, Ill understand. But I want to grow old with you. And if you want to live, please squeeze my hand and Ill try to figure out something to do to stop this thing. And I waited and he squeezed my hand, she shares.

Though elated, she was now presented with a seemingly insurmountable challenge: I realised Im not a medical doctor, what am I going to do? I am a scientist and I know how to research, Steffanie says.

So, I went home and I hit the internet and the National Library of Medicine has a free search engine that is like Google Scholar on steroids. Its open to the public, so even your grandmother can plunk in keywords like the name of a superbug and alternative treatments and up pops scientific literature thats been vetted and is based on real evidence, Steffanie says.

As an epidemiologist focusing on the HIV epidemic, the superbug crisis crept out from the shadows the more she researched. Buried in the literature she found her solution: phage therapy.

Read more about antibiotic resistance:

Though still regarded as an experimental treatment in the Western world, phage therapy was first used to treat bacterial infections in 1919. It involves deploying bacteriophages (bacteria-eating organisms) which can target and hijack bacteria cells to reproduce and kill the host cells.

With the rise of penicillin following WWII and subsequent geopolitical influences, phage therapy has been under-researched in the West. As a result, Steffanie had to convince her family that this experimental treatment was the right thing to do to.

After this she still faced series of obstacles. First, she had to find experts in the field willing to help her husband, and then they had to identify and purify the bacteriophages for treatment. To treat Tom, doctors would first need FDA approval. Schooley, who had first recommended taking Tom to a hospital, offered to help get FDA permission for bacteriophage treatment on a compassionate basis.

I was very excited again, but I was daunted by this seemingly impossible task because the more I learnt about phages, the stranger the whole idea got. Essentially, phage are the oldest and most populous organism on the planet. Theres 10 million trillion trillion and they have to match to the bacteria that you want to kill, says Steffanie.

Phages use specific receptors to attack the superbug, so she couldnt just use the most common phage for Tom. Steffanie now had to tackle the problem of finding the specific strain of bacteriophage that could save her husband.

Determined to find a solution, Steffanie emailed the few researchers she could find working on Acinetobacter baumanniiand the associated phages. Attaching a picture of Tom in his hospital bed, she reached out to the scientists in the field for help. Within 24 hours, she says she heard back from Professor Rylan Youngat A&M Texas University who reached out to others internationally. Young also refocussed his lab on looking for these phages from waste and sewage sources.

Isolating four relevant bacteriophages from sewage waste, the Texas lab then let it grow and tested it on a sample of the bacteria. After successful testing in a petri dish, the team had to purify their bacteriophages for human use.

SEM Image of Toms superbug, Acinetobacter baumannii, and the phages used to target and destroy it NBACC

In just a few weeks, Steffanie had a set of phages from Texas ready for use. The US Navy also provided a different set of active phages against Acinetobacter baumannii.

With permission for treatment on an emergency basis thanks to Professor Schooley, Steffanie had overcome an almost impossible task. Hours of research, discussion with doctors, contacting experts, and collaboration with labs alongside a hand-squeeze of hope had led Steffanie to a potential cure for Tom.

Usually phage therapy involves topical treatment, spreading the bacteriophages on the skin. But, with Toms dire condition, Schooley had scrutinised the research and, after speaking to experts, he recommended intravenously administering the phages. At the time, IV phage therapy had never been attempted in the US and they had to guess the dosage for Tom.

When we injected the phages into Toms bloodstream, nobody really knew if this was going to cure him or kill him. We did know that if we didnt do something, that he was going to die anyway. I was told that they expected him to die within a couple of hours, says Steffanie.

And yet, you know, three days after we started injecting the phage into his bloodstream, he lifted his head off the pillow, opened his eyes and kissed his daughters hand. It was just fantastic.

Steffanie says Tom has made an incredible recovery, and cleared the infection in three months. He can take long walks every day. He even takes out the garbage every time I ask, she says.

Learning microbiology in 1986, Steffanie could have never envisioned her lectures on bacteriophages would play such a role in her personal battle years later. Her work to save Toms life helped renew interest and research into phage therapy in the West which has treated others since.

Professor Steffanie now also directs a centre in San Diego focused on developing phage therapy for medicine. Research into phages and other therapeutic interventions will be key to overcoming the antibiotic resistance crisis.

Together, the pair published a book in 2019 about their experience and the potential of phage therapy,The Perfect Predator. Not quite the dream ending to their vacation in Egypt, but certainly a holiday story to trump all others.

Listen to Steffanie tell the story on theScience Focus Podcast:

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Meet the scientist who defeated 'the world's worst bacteria' to save her husbands life - BBC Focus Magazine

This morning, the Lewiston Tribunes Opinion page welcomes three additions to its lineup of columnists.

As noted last month, Rick Rogers of Clarkston and Jeff Sayre of Lewiston have completed their four-year assignments. Once again, the Tribune thanks Rogers and Sayre for their many contributions.

Filling in for them the next few years will be:

l Richard J. Eggleston of Clarkston. The 80-year-old retired ophthalmologists background includes growing up in Omaha, Neb., and Wichita, Kan. He graduated from the University of Dayton in Dayton, Ohio, attended medical school at Kansas University Medical Center, and served with the U.S. Army, including a frequently dangerous tour as a flight surgeon in Europe from 1968 through 1970. The 1974 Worlds Fair introduced him and his wife, Betty, to Spokane, where they lived until the mid-1980s, when they transferred to Clarkston.

l Bob Hassoldt of Kendrick. The 63-year-old came to Idaho in the mid-1970s to attend the University of Idaho, where he graduated in 1979 with a degree in forest resource management. His work with private landowners has taken him everywhere from rural New York state to southeast Alaska. Hassoldt served on the Latah County Planning and Zoning Commission as well as the Lewiston Tribunes Community Advisory Board. Hes also dabbled in politics, having waged campaigns for the Idaho Legislature and the Latah County commission.

To some degree, both are known commodities to Tribune readers through their frequent contributions to the letters page.

From Eggleston, you can expect such themes as the importance of fathers, the planned usurpation of liberties with COVID-19 as the excuse, the mathematical impossibility of macro evolution ... (and) the corruption in the hierarchy of my Catholic church.

For sure, some few readers will opine that I am uneducated, sexist, racist, homophobic, etc., he writes. Preemptively, I would inform them that I am board certified in two medical specialties ophthalmology and alternative medicine. I understand the scientific method, biology, heredity, mutations and the very brief whiff of life time during which our fate for eternity is determined.

Hassoldt intends to challenge the politicians, environmentalists, courts and academia that think they know more than the people, college-educated or not, that deal in this environment on a daily basis. Hell also scrutinize tax support for Planned Parenthood and what he considers the over-hyping of climate change while promoting more trade school and technical education.

Ill be civil but firm in my opinions and will back them up with hard facts, he writes. My desire is to get people to think and if I pop some liberal bubbles along the way, so much the better.

Eggleston and Hassoldt will join the Tribunes local columnists, former state Rep. Cindy Agidius of Moscow, and retired journeyman carpenter Marvin F. Dugger of Lewiston.

On another front, expect a bit of a shake up among the syndicated writers who appear on this page.

When political columnist David Broder died almost a decade ago, his syndicate at the Washington Post replaced him with submissions from Eugene Robinson and Dana Milbank. Both are exceptional writers with a keen sense of the national scene, but they contributed toward a left-of-center drift.

It didnt help when Donald Trumps presidency transformed conventionally conservative writers such as Kathleen Parker and George Will into never-Trumpers. Even Trump ally Marc Thiessen turned sharply critical with this months insurrection at the U.S. Capitol.

In the interest of ideological equilibrium, the Tribune will begin publishing Dennis Pragers column.

Prager has been a part of talk radio in Los Angeles for almost four decades. Since 1999, his program has been nationally syndicated Monday through Friday. As his listeners know, hes a foe of Obamacare and same-sex marriage and a staunch ally of Trump.

If you need a sample of his perspective, consider this: ... Since my graduate studies at the Russian Institute of Columbia Universitys School of International Affairs (as it was then known), I have always believed that only in a dictatorship could a society be brainwashed. I was wrong. I now understand that mass brainwashing can take place in a nominally free society. The incessant left-wing drumbeat of the New York Times, the Washington Post, the Los Angeles Times and almost every other major newspaper, plus the Atlantic, the New Yorker, CNN, ABC, CBS, NBC, PBS, NPR, all of Hollywood and almost every school from kindergarten through graduate school, has brainwashed at least half of America every bit as effectively as the German, Soviet and Chinese communist press did (and in the latter case, still does).

If nothing else, your mornings wont be tame. Pragers column begins appearing in the Tribune next week. M.T.

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Editorial: Shaking up the Tribune's columnist roster | Opinion - Lewiston Morning Tribune

SUPHANBURI Thailands government is treating for free thousands of patients suffering cancer and other illnesses with an until recently illegal brew of marijuana boiled in coconut oil, a concoction created by Daycha Siripatra who says a mind-reading Buddhist monk helped tweak its recipe.

Daycha also teaches the public how to make cannabis oil themselves, which is as easy as cooking soup on a kitchen stove.

An agricultural expert, Daycha is now government-licensed to make, prescribe, and distribute his now popular Daycha Oil to the public for common or serious ills. It wasnt easy to get licensed. In 2019, Thailand legalized medical cannabis, but not recreational or unlicensed use.

Almost two years ago, Daycha was nearly imprisoned. Police, military and anti-narcotic officials raided his makeshift laboratory in April 2019, seized about 200 marijuana plants and extracts, and threatened to jail him.

Supporters, patients, local media, medical experts and others voiced outrage. To avoid caging an altruist who appeared to help more than 8,000 cancer patients, a compromise was arranged.

The Office of Narcotics Control Board returned his marijuana plants and extracts. The Health Ministry quickly awarded him rare licenses to continue his work.

Today, among 16 approved medicines containing cannabis, the governments Department of Thai Traditional and Alternative Medicine (DTAM) uses Mr. Daychas formula for its DTAM Oil brand.

I gave them [the formula] for free because my patients were too many.

From us, about 20,000 patients currently receive Daycha Oil for free, he said. From the government, more than 100,000 people receive DTAM Oil for free through dozens of hospitals and clinics.

His interest began 10 years ago when he worried about contracting cancer after several relatives died from the disease even with chemotherapy.

He searched online for treatments and illegally experimented with a formula publicized by Canadian cannabis activist Rick Simpson.

Simpson suggested naphtha, a solvent, to extract oil from marijuana. To test the oil, Daycha secretly began treating two terminal cancer patients.

Unlike many other cannabis oils, Rick Simpson Oil is high in tetrahydrocannabinol (THC), which is the main psychoactive chemical in marijuana, WebMD.com reported.

The results appeared too intoxicating for Thais, though.

The two patients were drunk and could not do anything, Daycha said laughing in an interview. Our grade of marijuana is too strong, compared to Canadas. The patients refused to continue.

He sought local advice. Asians have used cannabis in traditional medicine for hundreds of years.

So I went to a Buddhist monk. You are surprised why I went to the monk? Because I used to be a monk before.

Daycha, 72, was a monk for about four months when he was 13, a tradition followed by most Thai males at sometime during their life. He believed an enlightened monk could read peoples minds.

I tested monks by asking the question in my mind. Then I said, If you know what is the question, and can answer correctly, you maybe have mind power.

Phra Lad Yom, a monk who seemed to perceive Daychas thoughts, told him cannabis oil was good for cancer patients if diluted.

He said, Dilute with cold press coconut oil. Thats very good. Mixed together. Very diluted.

So I diluted it for many percentages. The monk said, This one is good, three percent is best.

The monk suggested patients consume it before going to bed, because deep sleep is required for the medical affect. Daychas cannabis oil includes varying levels of THC and other cannabinols.

The percentage [of cannabis] is not fixed. We want three, but we can fluctuate, one to five.

We care about your sleep quality. If you take one drop and its not good, take two drops, three drops, until its good.

Unlike Simpsons recipe, diluted oil allows patients to easily adjust how many drops they should consume for deep sleep.

Rick Simpson Oil is too concentrated. If one drop is not enough, two drops are too much.

If too much, you become drunk. Its no use. If too low, its not enough, Daycha said.

Cannabis oil does not cure cancer, Parkinsons, Alzheimers, or other non-communicable diseases (NCD), Daycha said.

You must use your body to treat these kinds of NCD. Your body can do this task when you have deep sleep, longer than 90 minutes a night.

Marijuana oil can make you have very good sleep. You can test by this machine, he said, indicating a wristband Fitbit sleep tracker.

If you can have deep sleep without marijuana, its OK. Your deep sleep is the key to make your body to cure any kind of NCD.

He uses cannabis oil every night to improve his health.

Daycha heads his Khao Kwan Foundation here in Suphanburi, 62 miles (100 kilometers) northwest of Bangkok. He currently teaches the public to make their own cannabis oil during two-day workshops for about $80.

His recipe is simple:

Chop female marijuana buds and flowers into fine pieces, but not powder. Mix with coconut oil. Boil.

Not more than one hour. We must keep the temperature not over 130 degrees Celsius (266 degrees Fahrenheit), not lower than 110 degrees Celsius (230 degrees Fahrenheit). One hundred and twenty degrees (248 degrees Fahrenheit) is best.

I am training them to help themselves in health, using the cannabis or marijuana for medicine, not for recreation, because the law in Thailand does not allow for recreation.

At a recent workshop, Daychas slide show included charts comparing percentages of THC and other cannabinols in marijuana leaves, buds, flowers and kief.

One slide showed a painting of Hinduisms Lord Shiva blissfully smoking hashish in a traditional vertical chillum pipe.

At a recent public exhibition in Bangkok, Health Ministry officials distributed DTAM Oil for free to Thais who said they suffered insomnia, stress, cancer and other ailments.

Patients tended to have their quality of life improved, especially in cancer and neuropathic-pain patients, said Dr. Pakakrong Kwankao, head of Chaophraya Abhaibhubejhr Hospitals Empirical Evidence Center.

International tourists are next.

After becoming the first Southeast Asian nation to legalize medical marijuana, Thailand wants to soon treat international tourists with cannabis in health spas using traditional recipes mixing herbs with weed.

Neighboring nations are far behind with harsh anti-cannabis laws enforced across Malaysia, Singapore, Indonesia, Vietnam, Cambodia and to a lesser extent, Laos.

Officials in all those countries are comparatively timid about marijuanas medical potential compared to enthusiastic Thailand.

The cannabis-related medical products and services, now undergoing development along with other Thai herbs, could further promote the health and wellness tourism sector in Thailand, making the country one of the key global destinations for health tourism, the Government Public Relations Department announced on December 15.

Thailands increasingly liberal approach to marijuana includes cashing in on the medical sector and related businesses while keeping recreational use illegal.

Fear of foreigners and multinational corporations dominating the market has forced Bangkok to speed development of cannabis research labs, university courses, extraction and production facilities, plantations, and retail and licensing requirements, plus local and international laws and agreements.

Importing marijuana is restricted. But licensed medical and research officials are allowed to buy seeds from abroad to improve and diversify yields.

Thai Sticks and other local marijuana is world-renown for their steep euphoria. But some patients want only the plants medical benefits without being mentally interrupted.

Foreign investors are also set to soon benefit. But Thais must remain majority share-holders, according to Wirot Poonsuwan, a Bangkok-based lawyer.

Foreigners will be allowed to get involved, as long as they hold shares not exceeding one-third in a company incorporated under local law, Wirot wrote in a December report about Thailands private medical cannabis production.

International travelers are the most relaxed category and are always eligible to apply for import and export licenses to bring in and take out cannabis medicine to treat their illnesses, he said.

It was unclear how rapidly permission would be granted.

The Health Ministry and related facilities have been focusing on Covid-19 instead of their earlier plans to prioritize cannabis liberalization after legalizing medical use in 2019.

As a result, thousands of Thai patients are waiting to be treated with marijuana for common and serious illnesses while there is not enough locally grown and processed medical-grade cannabis.

To meet those needs, traditional folk healers are being given licenses to grow, produce, prescribe and sell cannabis for any sickness they believe it will relieve.

Richard S Ehrlich is a Bangkok-based American foreign correspondent reporting from Asia since 1978 and author of a new nonfiction book, Rituals. Killers. Wars. & Sex. Tibet, India, Nepal, Laos, Vietnam, Afghanistan, Sri Lanka & New York. Excerpts are available at https://asia-correspondent.tumblr.com

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Strange brew medical weed cooking in Thailand - Asia Times

The combination of naltrexone and bupropion results in a response rate almost six times greater than with placebo in patients with moderate or severe methamphetamine use disorder, results of a new randomized trial suggest.

"For the first time, there's hope for patients with methamphetamine use disorder who want to change, who want to stop using methamphetamine," lead author Madhukar H. Trivedi, MD, professor of psychiatry, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, told Medscape Medical News.

Dr Madhukar H. Trivedi

The results indicate that the combination therapy is safe and effective for use in clinical practice, Trivedi said. "Doctors should look into this carefully, prescribe it and push for getting it reimbursed by payers of patients' health insurance."

The study was published online January 13 in the New England Journal of Medicine.

The stimulant methamphetamine (also known as meth, ice, blue, and crystal) causes release of dopamine, norepinephrine, and other neurotransmitters, leading to powerful euphoric effects and increased energy. This very addictive drug is mainly used recreationally. It is identified as a Schedule II medicine according to the US Controlled Substances Act.

Methamphetamine use disorder is a serious condition associated with medical and mental health issues, functional impairment, and frequent relapses, the researchers note. The disorder has been on the rise in the United States, partly due to the crackdown on prescription opioids, but unlike opioid addiction, there are no approved medications to treat it.

While numerous studies have looked at many different medications to treat meth use disorder, "unfortunately" they have not been shown to be all that efficacious, Trivedi said.

The pathology related to the "complicated context" of stimulant use and the associated behavior "are very difficult to change," he said.

Identifying effective treatments is an essential public health goal, the authors said.

Bupropion, a stimulant-like antidepressant, acts through the norepinephrine and dopamine systems and might ameliorate the dysphoria associated with methamphetamine withdrawal that drives continued use. Naltrexone, an opioid-receptor antagonist, has been shown to be effective for the treatment of opioid use disorder.

Research suggests that used alone, bupropion and naltrexone have some efficacy for meth addiction. "Individually, they have been shown to have some signals, but not a large enough effect for me to say we should invest time, energy and money on this," Trivedi said.

The results of a small, open-label pilot trial indicated that naltrexone plus bupropion might be effective for the treatment of severe methamphetamine use disorder. These findings supported the development of the current randomized, double-blind, multisite trial known as ADAPT-2.

This two-stage study used a sequential parallel comparison design aimed to enhance the likelihood of detecting efficacy of the combination treatment. For the first stage, 403 adult participants were randomized to receive extended-release injectable naltrexone (380 mg every 3 weeks, instead of the typical 4 weeks) combined with once-daily oral extended-release bupropion (450 mg per day) or the same schedule of placebo.

The average age of participants was 41 years; 68.7% were male and 71.2% were White.

Participants had moderate or severe methamphetamine abuse, but most were "very severe," and using the drug on an almost daily basis, Trivedi said. Many also had coexisting substance use disorders involving cocaine, opioids, cannabis, or alcohol, which is not uncommon in addiction, he said.

Patients visited the clinic twice weekly for drug screening of urine samples. To encourage treatment adherence, they were educated on the importance of taking their medication regularly and as prescribed and were asked to use a smartphone-based application to track bupropion ingestion.

"We tried to make sure we implemented aspects of the study design and conduct that would mitigate problems with adherence that previous studies had encountered," Trivedi explained.

Those in the placebo group who did not respond in the first stage underwent randomization again in the second stage, which included 225 patients. The purpose of the rerandomization was to "try to mitigate the placebo response," Trivedi said.

He explained that in a number of conditions, including depression as well as methamphetamine, cocaine, and alcohol use disorders, "the fluctuating nature of the presentation of symptoms often interferes with the signal for drug efficacy," he said.

The design also involved use in each group of a weighted combination to analyze the responses in the two stages. Overall treatment effect was defined as the between-group difference in the weighted responses.

The primary outcome was a response, defined as at least three methamphetamine-negative urine samples out of a possible four samples obtained at the end of each stage.

At the end of the first stage, 16.5% in the treatment group and 3.4% in the placebo group had a response; at the end of the second stage, these figures were 11.4% and 1.8%, respectively.

After weighting and combining the percentage of responses across the stages, the overall weighted response was 13.6% in the treatment group and 2.5% in the placebo group, for a treatment effect of 11.1 percentage points (lower boundary of the 95% confidence interval, 6.3; Wald z-test statistic, 4.53; P < .001).

The number needed to treat for one patient to have a response was nine.

The finding of a treatment response that's almost six times better than placebo is "exciting," Trivedi said. He noted that this response is better than for treatments in fields like smoking cessation or depression.

"Importantly, for those people who got better, this is amazingly life-changing," he said.

A secondary outcome was the percentage of methamphetamine-negative urine samples. The researchers found this was 20.4% and 12.3% in the naltrexone-bupropion and placebo groups, respectively, in stage one, and 19.2% and 13.4%, respectively, in stage two.

For this outcome, the weighted difference between the two groups was 6.8 percentage points.

Additional secondary outcomes all favored the treatment vs placebo groups. The weighted differences for other measures included: methamphetamine craving scores on a visual analogue scale for the previous week (-9.7); depressive symptoms assessed with the Patient Health Questionnaire-9 (-1.1); and scores on the Treatment Effectiveness Assessment, which assesses reduced substance use and improvements in lifestyle, health, and community and interpersonal interactions (4.0).

Adverse events were mostly mild or moderate. Those that occurred more frequently (P < .05) with naltrexone-bupropion than with placebo were: nausea, vomiting, constipation, dry mouth, upper abdominal pain, dizziness, tremor, feeling jittery, malaise, hyperhidrosis, and decreased appetite. Serious adverse events occurred in 3.6% of the treatment group.

Strengths of the trial included a low attrition rate and high adherence to the trial regime. A limitation was the relatively low representation of women, although the authors pointed out the male-to-female ratio (68.7% were male) was consistent with the difference in incidence of amphetamine use disorder in the United States.

Future studies may help nail down the exact mechanism that explains the success of combination treatment, Trivedi said.

Commenting on the study for Medscape Medical News, Elie G. Aoun, MD, assistant professor of clinical psychiatry, Columbia University College of Physicians and Surgeons, Division of Law, Ethics, and Psychiatry, and vice-chair, American Psychiatric Association Council on Addiction Psychiatry, said he "loved it."

"The study is important because it found something that is somewhat effective," in treating meth use disorder, Aoun said, noting that the treatments used in the trial are already available.

As a self-confessed "research nerd," Aoun said he admired the study design and algorithm used to limit bias. He also pointed out that the study protocol involved not just doling out medicines but also frequent interaction between subjects and research staff.

"We know that talking to someone and engaging with them about drug use can have a small effect" on this use, Aoun said.

He called the study "a step in the right direction," and said he hopes it opens the door for more research into alternative treatment options for meth addiction.

However, the study doesn't provide all the answers, Aoun said. "We have to understand that it's not going to be effective for the majority of people."

While the number needed to treat of nine means one person may potentially benefit, "that leaves 8 people without effective treatment," Aoun added.

And although the response to the combination treatment is "much better than not having anything," which is the current situation, it's "not great," Aoun said. This, he added, is especially true when compared with interventions used in other addictions; for example, suboxone (an oral combination of buprenorphine and naloxone) for opioid use disorder.

"One of the biggest factors that changed the opioid crisis and treatment of opioid addiction was the development of medications that work, that are extremely effective."

A major incentive to find solutions to meth use disorder is the growing number of overdose deaths in the United States that has accelerated during the COVID-19 pandemic because people are more isolated and lonely, Aoun said.

And, just as opioid users are dying from ingesting fentanyl-laced drugs, so too are meth users.

"People on the streets who are addicted to meth are buying what they think is meth, only to find out these drugs are also laced with the opioid fentanyl," Aoun said. "It's creating a new generation of people who have an opioid use disorder who weren't intending to use opioids."

Complicating the meth abuse picture is the relationship between the drug and sex, Aoun said. "A lot of people use it almost exclusively in the context of sex," which may interfere with the ability to have an intimate relationship with a partner without it.

The study was supported by the National Institute on Drug Abuse (NIDA) of the National Institutes of Health, and the US Department of Health and Human Services. Trivedi reports receiving consulting fees from AcademyHealth, Acadia Pharmaceuticals, Alkermes, Allergan, Alto Neuroscience, Axsome Therapeutics, Boehringer Ingelheim, Vital Signs GreenLight, Janssen, Jazz Pharmaceuticals, Lundbeck, Medscape, Merck Sharp & Dohme, MSI Methylation Sciences, Myriad Neuroscience, Navitor, Otsuka, Oxford PharmaGenesis, Perception Neuroscience Holdings, Pharmerit International, Sage Therapeutics, Signant Health, and Takeda Pharmaceuticals USA; fees for serving on a data and safety monitoring board from Applied Clinical Intelligence; fees for serving on an endpoint review committee from Engage Health Media; and grant support, paid to his institution, from Janssen Research and Development, Johnson & Johnson Health Care Systems, and the Patient-Centered Outcomes Research Institute. Aoun has disclosed no relevant financial relationships.

N Engl J Med. Published January 14, 2021. Abstract

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Naltrexone and Bupropion Promising Combo for Meth Addiction - Medscape

Alternative And Complementary Medicine Marketresearch report is the new statistical data source added byA2Z Market Research.

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Regions Covered in the Global Alternative And Complementary Medicine Market Report 2021:The Middle East and Africa(GCC Countries and Egypt)North America(the United States, Mexico, and Canada)South America(Brazil etc.)Europe(Turkey, Germany, Russia UK, Italy, France, etc.)Asia-Pacific(Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia, and Australia)

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Chapter 1 Alternative And Complementary Medicine Market Overview

Chapter 2 Global Economic Impact on Industry

Chapter 3 Global Market Competition by Manufacturers

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As promised, Foo Fighters unveiled their timely new song Waiting On A War on Thursday.

The new track is off of their forthcoming 10th studio album Medicine At Midnight.

2021 has already been a big year for Foo Fighters. Along with ringing in the New Year with their recent song No Son Of Mine, Foo Fighters just announced a limited edition collab with Vans in celebration of their 25th anniversary as a band.

However, next month, things are going to get even more exciting for Foo Fighters. On Feb. 5, they are releasing their 10th studio album Medicine At Midnightwhich includes the lead singleShame Shame and its nightmarish video.

Now, Foo Fighters are giving fans another taste of their forthcoming album with Waiting On A War. The song, which the band teased earlier this week, is an autobiographical piece from Dave Grohl.

As a child growing up in the suburbs of Washington DC, I was always afraid of war, he says. I had nightmares of missiles in the sky and soldiers in my backyard, most likely brought upon by the political tension of the early 1980s and my proximity to the Nations Capitol. My youth was spent under the dark cloud of a hopeless future.

After having a very difficult, yet timely, conversation with his daughter, Grohl went on to write Waiting On A War.

Last fall, as I was driving my daughter to school, she turned to me and asked, Daddy, is there going to be a war? My heart sank as I realized that she was now living under the same dark cloud that I had felt 40 years ago, he says. I wrote Waiting on a War that day. Everyday waiting for the sky to fall. Is there more to this than that? Is there more to this than just waiting on a war? Because I need more. We all do. This song was written for my daughter, Harper, who deserves a future, just as every child does.

Previously, GrohlrevealedthatMedicine At Midnightis a critical release in Foo Fighters decades-spanning career.

Its filled with anthemic, huge, sing-along rock songs, he said. [Its] kind of like a dance record, but not an EDM, disco, modern dance record. Its got groove. To me, its ourDavid BowiesLets Dancerecord. Thats what we wanted to make, we wanted to make this really up, fun record.

Along with Foo Fighters upcoming album,Taylor Hawkinshas been busy in the studio with a few other familiar faces. ProducerAndrew Wattrecently shared that Hawkins isamong the musicians workingonOzzy Osbournes new album.MetallicasRobert Trujilloandthe Red Chili PeppersChad Smithare also part of Ozzys studio band.

Waiting On A War arrived on Thursday, Jan. 14 which is coincidentally Dave Grohls birthday. The Nirvana drummer and Foo Fighters frontman officially turned 52 years old this year. Fellow musicians, fans and friends took to social media to help celebrate the special day.

Medicine At Midnightarrives on Feb. 5 and pre-orders are availablehere.

What are your reactions to Foo Fighters new song? Which song off of Medicine At Midnight has been your favorite so far? Let us know in the comments below.

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Foo Fighters' "Waiting On A War" l 'Medicine At Midnight' l - Alternative Press