Monthly Archives: May 2020

A guide to Japanese cyberpunk cinema with three of its visionary directors – Dazed

Posted: May 14, 2020 at 6:10 pm

The provocative 80s movement, studded with the neon-slick works of Sogo Ishii, Shinya Tsukamoto, and Shozin Fukui, paved the way for a new filmic wave in Japan

In the mid-80s, the Japanese film industry was at an all-time low. Several of the major studios had gone bankrupt, and the ones that remained had either focused their attentions to softcore pornography or suspended production entirely in favour of distributing Hollywood imports. Even the most well-established directors struggled to secure funding. And independent cinema just wasnt economically viable.

The Japanese cyberpunk movement was a product of this filmographic impotence, and a total rejection of the traditions of Japanese cinema that had preceded it. The period dramas of Yasujiro Ozu, the samurai epics of Akira Kurosawa, and even the documentary-style yakuza dramas of Kinji Fukasaku had no place in a 1980s Japan that was experiencing a world-renowned technological revolution. Instead, a new generation of filmmakers with a critical view of the hyper-modern world were picking up video cameras as a means to attack the countrys shifting identity, creating wild dystopias that foreshadowed the economic crash that would hit Japan in the 90s.

Throughout the 80s, this provocative school of filmmaking was helmed by three renegade directors: Sogo Ishii andShinya Tsukamoto, film students at Tokyos Nihon University, and Shozin Fukui, a one-time crew member for each. But the short-lived cyberpunk movement was effectively over in Japan as soon as it emerged from the underground. When Tsukamotos avant-garde explosionTetsuo: Iron Manunexpectedly scooped the Best Film Award at Romes FantaFestival in 1989, it single-handedly revived international interest in Japanese filmmaking. The films success prompted serious investment in the countrys V-Cinema indie filmmaking system, laying the path for a new wave of filmmakers to thrive in the 90s.

This Maymarks 40 years since the release of Sogo IshiisCrazy Thunder Road the film that started the entire movement, and therefore the revival of Japanese cinema as a whole. On its ruby anniversary, Dazed traces the history of Japanese cyberpunk through its three most important directors.

Sogo Ishiis upbringing in Hakata, Kyushu, a mecca for Japans burgeoning punk scene in the 70s, would shape his attitude towards filmmaking when he was a student in Tokyo. He often attended lectures solely to appropriate school equipment, and this delinquent attitude would be the crux of his success after his 1980 graduation project Crazy Thunder Road was unexpectedly bought by Toei Film Studio for release in theatres.

Crazy Thunder Road, the genesis of the Japanese cyberpunk movement, set early precedents for what would become essential tropes of the genre. A raw and chaotic biker movie set between desolate urban wreckage and the neon streets of Tokyo, its roaring engines, and vicious gang warfare was the Japanese embodiment of rollercoaster thrillers like Mad Max and The Warriors. Cast almost entirely by the spiky-haired, leather-strewn band members from his punk circle, Ishiis movie offered an ominous vision of a society in turmoil through hordes of armed thugs and erratic night-time brawls.

The visual and thematic similarities to Akira, the 1988 biker-punk sci-fi that would be considered the apotheosis of cyberpunk anime, are uncanny. And while the goblin-masked, metal-clawed acolytes of Crazy Thunder Road only hint to the themes of bodily metamorphosis that would follow, the films in-your-face camerawork and brash rockabilly soundtrack established a riotous template for cyberpunk to build on.

Ishii would expand his own blueprint two years later with Burst City, a chaotic action-punk-musical hybrid that catapults the bleak world of Crazy Thunder Road into a dark and cold dystopian future. From the opening shot, wherein a vehicle-mounted camera loudly tears through a cityscape at Mach speed, the film sets off like a rocket. It remains explosive right up until the climax a showdown between warring cops, gangsters and guitar-shredding punks amidst the smoke and rubble of a long-since decimated society.

Disorientating mosh pit footage spliced from concerts performed by films cast (peroxide-haired Tokyo punk bands The Stalin, The Roosters, and The Rockers) do plenty to interrupt the standard narrative format. And even the dilapidated, scrapheap world these characters live in feels palpable, not least due to the fact that the majority of the cast lived on set for the entire shoot. But perhaps the most important practice put to use in Burst City, would be Ishiis abundant use of undercranking.

A technique whereby film is initially shot at a lower speed and later manipulated in playback to create a hyper-kinetic visual effect, undercranking would serve as one of the stylistic cornerstones of cyberpunks expressionism. Alongside jagged jump cuts and jerky handheld camera, these methods would be adopted by one Shinya Tsukamoto, a freshman while Ishii was in his senior year at Nihon University who had already begun crafting his own subversive shorts.

The Phantom of Regular Size, the 18-minute, 8mm film that kicked off Tsukamotos career in 1986, was effectively a dummy run for what would be the defining film of Ishiis movement three years later. While the plot of Phantom is moot, the entire cast plus several of the shorts most vivid scenes would all re-appear in Tetsuo: Iron Man in 1989. Among the most notable is a sequence wherein a bespectacled salaryman is terrorised by a malformed woman in the Tokyo subway. The climactic image of a man with a roaring power drill bursting from his nether regions, meanwhile, would end up being one of the most defining images of the entire cyberpunk movement.

The Phantom of Regular Size also offered a first look at Tsukamotos vital evolution of Ishiis undercranking into what would become his signature shot. His hybrid stop-motion technique would create the appearance of a subject traversing an environment at impossible speed; an unnatural and jarring movement of characters and objects across a given scenography. In Tetsuo it is used to make seas of metallic cables and wires writhe like snakes, and to make the movements of the films tortured subject, a man who is gradually, excruciatingly transformed into metal, all the more unnerving.

Commonly referred to as the Japanese Eraserhead for its grainy 16mm black-and-chrome industrial setting and surreal, nightmarish atmosphere, Tetsuo: Iron Man takes the intense expressionism of its predecessors to their limit. It offers a world corrupted entirely by junkyard scrap, with the enduring sounds of television static and Chu Ishikawas relentless, chiming soundtrack mirroring the films singular theme explicitly. Your future is metal! offers the antagonist in one of the films few pieces of dialogue a statement that underpins the anarchic vision of the cyberpunk movement in totality.

Shot over a painstaking 18 months marred by crew walkouts, Tsukamotos crowning achievement is abrasive, disorientating, and violently sexual. But the merit of its inventiveness was enough to prompt not only a cathartic festival win in Rome, but also a distribution deal in the USA, and later Europe. Tetsuo was truly the zenith of the movement, a sensory overload that introduced the world to a renegade style of low-budget filmmaking in Japan. But it was also the death knell for live-action cyberpunk; a filmmaking kamikaze that left its successors in its mercurial wake.

Shozin Fukui had offered some of the most hyperactive examples of the cyberpunk oeuvre in the years that preceded Tetsuo. The three-minute black-and-grey attack-on-a-stranger Scourge of Blood features some of the most exhilarating examples of editing in a canon of intensely cut films, while Gerorisuto, a grainy snapshot of a possessed woman on a train would demonstrate Fukuis passion for guerilla filmmaking. Caterpillar, a 1988 short film made while Fukui was working as an assistant director on Tetsuo, would recycle the same sets used in Tsukamotos film. It was his final exercise in perfecting cyberpunks stop-motion, shakycam manifesto before moving into full-length cinema.

But by the time Fukui got round to directing his own feature-length cyberpunk film, Tetsuo had already served the double-edged strike that simultaneously legitimised and upended the movement. It is for this reason that Fukuis 1991 film 942 Pinocchio (also known as Screams of Blasphemy), while of great enough quality to be screened at Rotterdam Film Festival and to receive a US video release, remains criminally under-seen in the West.

A loose, twisted translation of the classic Disney story, 924 Pinocchio finds a lobotomised sex slave cyborg abandoned in a hallucinogenic neo-Tokyo with no concept of his identity. Adopted by a similarly ostracised woman named Himiko, he learns to speak, and even to love, before a strange power is awakened with him that leads him to a bloody showdown with both his adopted mother-lover and his creator.

Set in a vividly-coloured 2064, the future setting of 964 Pinocchio is a departure from the cold, desolate worlds of Fukuis contemporaries. Blue skies, bustling streets, and an ethereal electronic soundtrack offer an almost utopian spirit to this tangible sci-fi world. But the tragic Pinocchio is destined never to fit in, as illustrated in the films most distinguished sequence: in a fit of despair, the cyborg runs screaming through the streets of Tokyo, the camera neurotically cutting and jerking as thousands of horrified real-life onlookers look on.

Through its developed narrative and revised aesthetic, 964 Pinocchio offered a natural progression for the cyberpunk genre, without disposing of the hurricane filmmaking style that made it so intoxicating. But it would take Fukui five years to deliver his next film, a perverse and unpalatable number would ultimately represent a nail in the coffin for the original cyberpunk movement.

Set entirely in a crude, industrial laboratory called The Unit (a clear reference to Japans notorious Unit 731, an experimental research unit responsible for some of WW2s most heinous war crimes), Rubbers Lover is a nightmarish exercise in sadism, torture, and BDSM that concludes the cyberpunk movement in a disturbing fashion. While as stylistically emphatic as its prestigious precursors, it pushes the boundaries of taste far beyond what had previously been attempted, foreshadowing the rise of extreme Asian cinema and splatter horror films like Ringu and Audition at the turn of the century.

Filmed in black-and-white from all manner of disorientating angles, Rubbers Lover deserves credit for delivering some of the most creative and striking images of Fukuis catalogue. One scene, wherein a patient is secured to a hospital bed by wired metal headgear, foreshadows the designs used in The Matrix by several years. The spinning eyeballs that flicker on a wall of computer monitors in the background, meanwhile, feel like they are plucked straight from A Clockwork Orange. But despite such artistic flair, the film virtually borders on avant-garde snuff. Scenes of prolonged and violent sexual assault, shot in intrusive and unforgiving close-up, push the boundaries of taste and make for particularly uncomfortable viewing.

A closing scene featuring reels of celluloid video film falling from the ceiling appears to signpost the demise of live-action cyberpunk in 1996. With director Takeshi Kitano winning the prestigious Golden Lion award at Venice the following year for poignant crime drama Hana-bi it was all but confirmed that a different kind of Japanese cinema was now in vogue.

By the turn of the century, cyberpunk had been relegated to the memory of Japans thriving indie filmmaking community, now headed by the likes of Hideo Nakata, Takashi Miike, and Takeshi Kitano. After Rubbers Lover, Shozin Fukui wouldnt return to filmmaking in any capacity for another ten years. Tsukamoto, the cyberpunk director, basically abandoned the movement after the release of Tetsuo and its diminished 1991 sequel-remake (2009 threequel Tetsuo: The Bullet Man, being the only exception). Ishii, though, would return to the genre for one final hoo-rah in 2001 with Electric Dragon 80.000V, a 55-minute pet project that served as a love-letter to the movement he had spawned two decades prior.

A black and white comic-book style caper about a pair of electrically-charged super-heroes in a near-future metropolis, Electric Dragon 80.000V is a blitz of super-charged filmmaking flair that lifts as many cyberpunk tropes as it can handle in its pristine runtime. Many scenes and characters feel satisfyingly familiar. Punk protagonist Dragon-Eye Morrison dwells in a metal-strewn warehouse, discharging the electricity that flows through him by plugging into his electric guitar and noisily letting loose in front of hundreds of bemused onlookers in the streets of Tokyo. Steel-masked antagonist Thunderbolt Buddha, meanwhile, looks as if hes been plucked directly from the thuggish ranks of one of Ishiis earliest projects. With a general lack of plot or dialogue, relentless staccato editing, and an armful of light-speed tracking shots, its a cyberpunk classic one generation removed.

Electric Dragon 80.000V debuted at the International Film Festival of Rotterdam in 2001 a feat unimaginable for a film of this style when Ishii started his filmmaking career. But its palpably high production values, untainted photography, and comic-influenced animation also represent a departure from the classic cyberpunk texts of the 80s and early 90s. And as the image of Thunderbolt Buddha tracking his rival via GPS on a modern desktop computer confirms, the breakdown of technology (and therefore society) has not taken place, after all; in 2001, Ishii and cos vision of the future was already outdated.

Somehow it seems almost fitting that, despite their cultural significance, many of these rebellious films remain underground obscurities, banished to the realm of out-of-print DVD copies, midnight art screenings, and foreign VHS imports. But the sonic boom of Japanese cyberpunk can still be heard in all kinds of creative cinema. Cyberpunk laid down the gauntlet for a new kind of filmmaking in the 80s and 90s one that revolutionised Japans industry and allowed it to become what it is today.

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How Five Feet Apart a story about Cystic Fibrosis is relevant today – stopthefud

Posted: at 6:07 pm

BY: HILARY PEARSON

One thing most of us have learnt during this pandemic: germs can spread as far as six feet when someone coughs or sneezes. They can land on surfaces, such as a doorknob, or in another persons eyes, nose, or mouth. Thats why social distancing guidelines state we should be standing six feet apart to limit the spread of the Corona virus.

For people with Cystic Fibrosis (CF), social distancing has always been a way of life. Being close to others with the disease puts them at increased risk of getting and spreading dangerous germs and bacteria, a term referred to as crossinfection. Not only are these dangerous germs difficult to treat, but they can lead to worsening symptoms and faster decline in lung function for those with CF.

Thats why its important for people with CF to stay at least six feet away from others with CF and anyone with a cold, flu, or infection.

Ive listened to this audiobook, Five Feet Apart, a few times now.

Stella Grant a teen living with CF describes her experience living with chronic illness:

Counting out exact doses of multiple medications. Being extra careful to not forget one. Careful to not accidentally overdose. Careful to take them at the specified time. Missing out on social events due to a flare up of symptoms. Going to the hospital because of catching a cold. Were basically doctors by the age of twelve.

I feel this. All the work that goes into my fight with my disability. Chronic pain. Chronic fatigue. Chronic migraines. Chronic asthma. Memory loss. Aphasia. Photophobia. Phonophobia. Post concussion syndrome. Brain damage.

I cant begin to understand what CF individuals have to go through. I dont know their fight. But I can begin to connect with the things we feel. Like the isolation. The complicated relationships. The chronic everything.

Even if you dont have a chronic condition, I still recommend reading this book.

We are all fighting in this pandemic. We can all begin to relate to those who need to always keep social distancing in mind.

We can all begin to see each other.

Hilary is a Toronto-based non-fiction writer and UofT masters student. Hilary is recovering from TBI, PCS and spends much of her free time on FaceTime with Isla, her baby niece.

This post originally appeared on her Instagram, @halite_brain_beads

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Two reasons why the market is missing a trick with CF Industries Holdings Inc – Stockopedia

Posted: at 6:07 pm

Buying quality merchandise when it's on sale is a stock market strategy used by some of the greatest investors in the world - including Warren Buffett. After theturmoil we've seen in 2020, there are signsthat stocks likeCF Industries Holdings Inc(NYQ:CF) could fit that bill. But how can you tell?

TheCF share price has moved by-37.3%over the past three months and its currently trading at24.59.

In volatile conditions,many investors are keen to buy what they think are cheap stocks- but this can be a mistake. It's importantknow the difference between a genuine bargain and a value trap - and often, the quality of the stock makes all the difference.

The good news is thatCF scores well against some important financial and technical measures.It's a large-cap share with strong exposure to twovery influential drivers of investment returns: high quality and a relatively cheap valuation.

To understand where that shows up,here's a closer look:

GET MORE DATA-DRIVEN INSIGHTS INTO NYQ:CF

Good quality stocks are loved by the market because they'remore likely to be solid, dependable businesses. Profitability is important, but so is the firm'sfinancial strength. A track record of improving finances is essential.

One of the stand out quality metrics forCFis that it passes8of the9 financial tests in the Piotroski F-Score. The F-Score is a world-class accounting-based checklist for findingstocks with an improving financial health trend. A good F-Score suggests that the company has strong signs ofquality.

While quality is important, no-one wants to overpay for a stock, so an appealingvaluation is vital too. With a weaker economy, earnings forecasts are unclear right across the market.But there are some valuation measures that can help, and one of them is the Earnings Yield.

Earnings Yieldcompares a company's profit with itsmarket valuation (worked out by dividing itsoperating profit by its enterprise value). It gives you a total value of the stock (including its cash and debt), which makes it easier to comparedifferent stocks. As a percentage, the higher the Earnings Yield, the better value the share.

A rule of thumb for a reasonable Earnings Yield might be5%, and theEarnings Yield forCFis currently8.06%.

In summary, good quality and relatively cheap valuations are pointers to those stocks that aresome of themost appealing to contrarian value investors. It's among these shares that genuine mis-pricing can be found. Once the market recognises that these quality firms are on sale, those prices often rebound.

Finding good quality stocks at attractive prices is a strategy used by some of the world's most successful investors. If you want to find more shares that meet these rules, you can see a comprehensive list on Stockopedia's StockRanks page.

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See what the CF Snowbirds saw: Video shows Waterloo Region from the cockpit – CTV News

Posted: at 6:07 pm

KITCHENER -- Can you see your house from here?

The CF Snowbirds passed over Waterloo Region last week as part of Operation Inspiration, aiming to boost morale for Canadians across the country amid the COVID-19 pandemic.

After being delayed by a day because of visibility issues, the nine-plane formation passed over the region on Sunday, leaving their signature trail as they flew wing-to-wing.

If you saw the Snowbirds, there's a chance they could see you, too: video from the cockpit appears to show the jets as they made their pass over the region.

The Snowbirds are making their way across the country. By Thursday, they were passing over parts of Saskatchewan in their cross-country tour.

The team said their priority was to fly over hospitals and also residential areas.

"We prioritized the residential areas to make sure people could stay home and continue to social distance but also hopefully get a show from us," says Cpt. Joel Wilson.

Days later, the Waterloo Warbirds held their own flyovers to salute frontline workers, this time over Waterloo Region and Guelph.

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Is there a link between coronavirus and vitamin D deficiency? This startup just raised cash to find out – GeekWire

Posted: at 6:06 pm

Solius light therapy kiosks use a narrow spectrum of ultraviolet light that can stimulate the production of critical hormones and peptides, and increase vitamin D levels. (Solius Photo)

New research shows a potential correlation between severe vitamin D deficiency and COVID-19 mortality rates. A Northwestern University study released last week found that patients from countries with high death rates had lower levels of vitamin D compared to patients in countries with fewer mortalities.

Seattle-area startup Solius, which sells light therapy kiosks that can help people increase vitamin D levels, suddenly finds itself in a unique position amid the global pandemic.

The company today announced additional investment from Human Longevity Inc. as it explores how its technology could play a role in the fight against COVID-19 by strengthening the immune system and reducing the severity of the disease.

Further studies will be needed to validate this connection and we are working to engage in clinical trials that will prove the efficacy of our device on this devastating disease, said Solius CEO Bob Wise.

Researchers from Northwestern cautioned that vitamin D levels wont prevent contraction of COVID-19, but could make a difference in how the body fights the disease. They found a correlation between vitamin D levels and cytokine storm, a condition caused by an overactive immune system.

Cytokine storm can severely damage lungs and lead to acute respiratory distress syndrome and death in patients, Ali Daneshkhah, a postdoctoral research associate at Northwestern, said in a press release. This is what seems to kill a majority of COVID-19 patients, not the destruction of the lungs by the virus itself. It is the complications from the misdirected fire from the immune system.

Another study from Anglia Ruskin University in the U.K. found an association between low average levels of vitamin D and high numbers of COVID-19 cases and mortality rates across 20 European countries.

Some experts criticized the Northwestern study which has not been peer-reviewed for not controlling major confounding factors, among other reasons, Inverse reported.

Solius published its own white-paper this week about the impact of vitamin D on COVID-19. The company cited cytokine storms and studies that show vitamin D combating respiratory infections. It also quoted former CDC director Dr. Tom Frieden, who said in March that regular physical activity and adequate vitamin D levels probably have the most scientific evidence to increase resistance to COVID-19 infection.

Solius is working with leading phototherapy and vitamin D experts to develop and execute its own trials to study how the companys kiosks could treat and/or prevent COVID-19.

Foundational research strongly suggests a link between vitamin D and COVID-19 outcomes, Wise said. We look forward to adding to this body of research and investigating the impact our technology may have on supporting human health in response to the COVID-19 pandemic.

Solius light therapy uses a narrow spectrum of ultraviolet light that can stimulate the production of critical hormones and peptides. In 2018 it started rolling out light therapy kiosksin Vancouver, B.C., that help users increase vitamin D levels.

The therapy is an alternative to vitamin D pills, a solution that Soliuspreviously told GeekWireisnt sufficient to address the problem of vitamin D deficiency.

An estimated 1 billion people worldwide have inadequate levels of vitamin D, according toHarvard University, and research shows that deficiency is a more pressing problem than once thought.

Wise said the company expects FDA approval for its kiosks next year.

We are excited to invest in SOLIUS as its mission is to provide the benefits of the sun without the harmful rays to unlock the healing powers of the human body, Wei-Wu He, executive chairman at HLI, said in a statement.

Solius has raised $18 million to date. The 7-year-old company has seven employees. Wise replaced former CEO Rick Hennessey, who relocated to Florida for family reasons.

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Skincare Tips To Help You Take Good Care Of Your Skin – Longevity LIVE

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Whats the largest organ in the human body? The heart? Perhaps the kidney? Nope, think again. The largest organ in the human body is the skin. In fact, the average adult human skin spans 21 square miles and contains 11 miles of blood vessels. To put it in perspective, thats twice the height of Mt. Everest. No wonder skincare is such a booming economy!

Besides fascinating fun facts, your skin plays a crucial role in ensuring your optimum health. It provides proper regulation of body temperature and acts as a defense mechanism against invaders such as toxins and allergens. While skin plays a significant role in protecting the body, it is also the most vulnerable organ. There are at least 3,000 documented skin disorders. It is for this reason that taking care of your skin isnt a luxury its a necessity.

A google search on good skincare will reveal an almost dizzying variety of tips and tricks. Cutting through the clutter and finding what works for you can be frustrating. Thats why well make it easy for you. Lets do a deep dive into the proven steps to proper skincare. Before that, however, lets conduct a mind surgery.

For a good number of people, healthy and glowing skin is only a daydream or a reserve of pop stars and celebrities. Others consign themselves to the notion that natures genetic lottery hasnt been too kind to them. Nothing could be further from the truth. No matter the type of skin you have, good skincare can make it look better and healthier.

Of course, you may not glow like your favorite celebrity or model, but youd certainly look better than when you started. All it takes is consistency, dedication, and patience. Dont expect to see results right off the bat. Just like any organ in the body, the skin needs time to demonstrate results. One of the most common reasons people dont give extra attention to their skin is because they think their efforts wont make a difference. Breaking this barrier is the first step to achieving good skincare. Here are other proven steps to making your skin glow.

Any dermatologist worth their salt would tell you that skincare is not a one-size-fits-all solution. What works for one skin type may not necessarily work for another. Many factors play a role in determining how the skin looks. These factors include age, skin disorders, and DNA, amongst others.

One of the key factors is the type of skin in question. Its vital you know your skin type as it would have far-reaching effects on what products and procedures you can use. Some estimates peg the number at seven or even more, but there are at least five different skin types. Lets examine what each of these skin types entails.

This type of skin lacks oil. It is usually flaky and often gets cracked. Its not what you would call an ideal skin. Its pores are typically small with visible lines and it hardly stretches out. This skin type is likely to sport some red patches.

Oily skin features a greasy and shiny appearance. Oil glands naturally produce oil on the surface of every skin. With oily skin, the glands go into overdrive secreting more than necessary. This skin type usually has large pores and is prone to breakouts, particularly acne breakouts.

Normal skin straddles the line between dry and oily skin. It has little or no blots. Its sensitivity is just right, and its pores are almost invisible. It can handle most irritations without breaking out. Some people refer to normal skin as healthy skin, and it is considered the most desirable skin type.

Sensitive skin is one that typically overreacts to almost anything. You can develop this skin if you over-scrub or do not take care of your original skin type. One of the skin types that can quickly morph into a sensitive one is the dry skin. Sensitive skin is prone to skin diseases such as acne or contact dermatitis. If you have this skin type, be sure to avoid triggers that may cause irritation or inflammation. Some of these triggers include alcohol, stress, and even smoking.

As the name suggests, combination skin is a mixture of different skin types. In other words, one person can have varied skin types in different places. One part may be dry while another may be oily, particularly the T-region. It means youll need a combination of solutions to keep the skin healthy and moisturized. You can read this article to find out more about skin types and how to take care of them.

Proper skin cleansing is fundamentally about removing any material that clogs the pores of the skin. Substances like dirt, dead skin cells, and makeup can clog the surface, but a good cleansing regime helps the skin breathe. In a general sense, bathing is the way to cleanse your skin. You must bathe or shower at least once or preferably twice a day to keep your skin moist and refreshed.

The first place most people look at when they meet you is your face. So, your cleanup should start from there, and your face should always feature prominently in any cleansing routine. But how hard could it be? Doesnt it just involve splashing some water over the skin and scrubbing a bit? Well, not quite. Theres more to facial cleansing. Here are a few helpful tips to follow:

It is for good reason that medical personnel often prescribe water as the first response to many diseases. In fact, medical practitioners regard water as the best medicine. It has several benefits to the body, and listed below are some of them.

If youre a water addict, your immune system will benefit greatly. Your immune system is essentially your bodys defense against diseases and toxins. Without a healthy immune system, youre vulnerable to many diseases, and your skin will suffer for it. Earlier, we mentioned that there are at least 3000 diseases associated with the skin. A robust immune system is a surefire way to ward off all intruders.

No one needs to tell you when you stand before a glowing skin. When it isnt glowing, everyone will know. Your skin will betray you if youre not taking in enough water: it will be cracked, flaky scaly, and dry. On the other hand, the skin surface of a person who drinks enough water is likely to be soft and supple.

Studies show that taking in water has a direct bearing on weight loss. If youre overweight, your body is likely to suffer stretch and strain. Maintaining a healthy weight is key to ensuring healthy skin, and gulping down glasses of water is a natural and safe way to shed the extra pounds.

Imagine your stool without water. How about urination? How would you even sweat without water? Hard to imagine, isnt it? Thats because water is such an essential part of our bodys processes. Additionally, guzzling on water helps the skin maintain a stable temperature, a process known as homeostasis. All these benefits of drinking water ultimately have far-reaching effects on the skin. In addition to drinking water, eat foods that can help you stay hydrated.

Its no surprise that some have labeled collagen supplements as the fountain of youth. To understand the reason for that statement, youd need to appreciate what collagen is. Collagen is the bodys most abundant protein. It makes up 75% of the average adults dry skin mass.

Others refer to collagen as the scaffolding of the skin. It ensures the integrity of the bodys tissues, bones, and tendons, and it plays a vital role in promoting skin health. As the body ages, it supplies less and less collagen. By the age of 30, the bodys collagen supply begins to decrease. This situation creates a deficit that needs addressing. Thankfully, there are supplements like collagen peptides that are an excellent resource to help you gain and maintain a glowing skin.

Whether you have oily, healthy, sensitive, or dry skin, you have to keep your skin hydrated. As mentioned earlier, water helps to moisturize the skin. However, it is not the only moisturizer for your skin. Look for moisturizer products with a hyaluronic acid-base. The acid is known to have an excellent hydrating ability. You can also opt for a humidifier. Such products help keep the air and atmosphere humid, thereby keeping your skin moist.

As much as youd want to take the first steps to get good skin by yourself, a dermatologist brings so much more to the table. These skin doctors are trained over several years to know how to preserve and take care of any skin type. Look for one who is trained, appropriately licensed, and can make time for you. If youre looking for cosmetic solutions, you can go to a specialist cosmetic dermatologist. Theyd examine your skin and make treatment recommendations for you.

Even if you dont want to have skin that gets the glares and the stares, you wouldnt want any skin disorder disturbing your skin. To understand how to take care of your skin, youd need to understand the complicated nature of the skin. Know your skin type so you can use the right remedies. Clean your skin regularly through bathing and facial cleansing to keep your youthful glow. Drinking lots of water is a fool-proof strategy for gaining good skin health.

Additionally, collagen supplements have a way of shoring up your skin and keeping it youthful. However, dont forget to consult your dermatologist for expert opinion and advice. Take advantage of all of the steps listed in this article to give your skin a worthwhile treat.

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Anti-Senescence Therapy Market Share Analysis and Research Report by 2025 – ZZReport

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Research Report onAnti-Senescence Therapy Market size | Industry Segment by Applications (Cardiovascular Diseases, Neural Degenerative Diseases, Ophthalmology Disorders and Others), by Type (Gene Therapy, Immunotherapy and Others), Regional Outlook, Market Demand, Latest Trends, Anti-Senescence Therapy Industry Share & Revenue by Manufacturers, Company Profiles, Growth Forecasts 2025.Analyzes current market size and upcoming 5 years growth of this industry.

The Anti-Senescence Therapy market size report is an intrinsic study of the current status of this business vertical and encompasses a brief synopsis about its segmentation. The report is inclusive of a prediction of the market scenario over the forecast period Anti-Senescence Therapy market size with respect to valuation as sales volume. The study lends focus to the top magnates comprising the competitive landscape of Anti-Senescence Therapy market, as well as the geographical areas where the Anti-Senescence Therapy industry extends its horizons, in magnanimous detail.

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Anti-Senescence Therapy market competition by top Manufacturers:

Anti-Senescence Therapy Market Outlook by Applications:

Anti-Senescence Therapy Market Statistics by Types:

An outline of the Anti-Senescence Therapy market share segmentation:

Key highlights of Anti-Senescence Therapy market analysis report:

The Anti-Senescence Therapy market report enumerates quite some details about the factors impacting the industry, influence of technological developments on the vertical, risks, as well as the threats that substitutes present to the industry players. In addition, information about the changing preferences and needs of consumers in conjunction with the impact of the shifting dynamics of the economic and political scenario on the Anti-Senescence Therapy market has also been acknowledged in the study.

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Anti-Senescence Therapy Market Share Analysis and Research Report by 2025 - ZZReport

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AgeX Therapeutics Reports First Quarter 2020 Financial Results and Provides Business Update – Business Wire

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ALAMEDA, Calif.--(BUSINESS WIRE)--AgeX Therapeutics , Inc. (AgeX: NYSE American: AGE), a biotechnology company developing therapeutics for human aging and regeneration, reported financial and operating results for the first quarter ended March 31, 2020.

The human tragedy of this pandemic has long tentacles that effect numerous businesses including AgeX, said Greg Bailey M.D., Chairman. Given the current global economic landscape, and the changes that businesses will need to make to accommodate to a post pandemic world, we feel that new business model aligns well to be able to function in this new environment. We see enormous opportunity to license and joint venture PureStem and HLA-G while implementing a definitive plan to begin preclinical trials on tissue regeneration under the leadership of Michael West and Michael May. We will update you in the future as these plans progress.

AgeX has completed a company restructuring to help set it up for success in the future. The combination of company priorities, cash position and the COVID-19 pandemic led to employee lay-offs designed to support the evolution of AgeX's current team to execute on strategic business goals going forward and to ensure cash is directed at near-term priorities to deliver maximum shareholder value. AgeX has a dual business strategy to diversify risk and maximize opportunities. It plans to continue to pursue its licensing and collaboration strategy for its two primary technology platforms, UniverCyte immunotolerance technology for the generation of universal cells, and PureStem cell derivation and manufacturing technology for the production of therapeutic cells with potential advantages, including industrial scalability and lower manufacturing costs. Since the launch of its licensing and collaboration strategy in January 2020, AgeX has delivered a research collaboration in Japan focused on developing universally transplantable cells for therapeutic use based on UniverCyte, entered into a neural stem cell therapy research collaboration for neurological disorders utilizing PureStem at a California University, and AgeX licensee ImStem Biotechnology received the first-ever clearance of a cell therapy derived from AgeXs embryonic stem cells by the FDA to enter human studies.

In addition, AgeX remains committed to pursuing in-house cell therapy product development and plans to raise money to build the optimal team to deliver on its products, AGEX-BAT1 for metabolic diseases such as type II diabetes and AGEX-VASC1 for tissue ischaemia. AgeXs budgetary and personnel adjustments will result in the deferral of in-house product development and may also lead to AgeX seeking arrangements with other companies in the cell therapy or biopharma industry for the development of its product candidates and technology, or outsourcing of some of that work to service providers until further funding can be obtained to rebuild in-house research and development staff for one or more of those programs. Development of AgeXs iTR technology may be done at AgeXs subsidiary Reverse Bioengineering, Inc. subject to successful financing of the subsidiary.

Upwards of 80% of healthcare expenditures in the United States relates to chronic degenerative disease and aging is a principle underlying cause of such conditions, said Michael D. West, Ph.D., AgeXs Chief Executive Officer. Therefore, the ability to manufacture to scale young clinical-grade cells capable of regenerating functionality in diverse tissues of the body has the potential to transform healthcare as we know it today. Perhaps even more noteworthy is the potential of reversing developmental aging in the body itself through AgeXs iTR technology. Our goal in the coming year is to advance the development of our intellectual property with the goal of bringing value to our shareholders.

Q1 Highlights

Liquidity and Capital Resources

AgeX is in need of additional capital to finance its operations. On March 30, 2020, AgeX entered into a Secured Convertible Facility Agreement (the New Loan Agreement) with Juvenescence Limited pursuant to which AgeX may borrow funds from time to time. On April 1, 2020 AgeX drew the initial $500,000, and may draw additional funds from time to time subject to Juvenescences discretion, prior to the contractual repayment date on March 30, 2023. AgeX may not draw down more than $1 million in any single draw. More information about the New Loan Agreement can be found in AgeXs Annual Report on Form 10-K and Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on March 30, 2020 and May 14, 2020, respectively.

On April 13, 2020, AgeX obtained a loan in the amount of $432,952 from Axos Bank under the Paycheck Protection Program (the PPP Loan). The PPP Loan will bear interest at a rate of 1% per annum. No payments will be due on the PPP Loan during a six month deferral period commencing on the date of the promissory note. Commencing one month after the expiration of the deferral period, and continuing on the same day of each month thereafter until the maturity date of the PPP Loan, monthly payments of principal and interest will be due, in an amount required to fully amortize the principal amount outstanding on the PPP Loan by the maturity date. The maturity date is April 13, 2022. The principal amount of the PPP Loan is subject to forgiveness under the PPP to the extent that PPP Loan proceeds are used to pay expense permitted by the PPP, including payroll, rent, and utilities (collectively, Qualifying Expenses), during the time frame permitted by the PPP. AgeX intends to use the PPP Loan amount for Qualifying Expenses. However, no assurance is provided that AgeX will obtain forgiveness of the PPP Loan in whole or in part.

Staff Reductions

During April 2020, AgeX initiated staff layoffs that affected 12 employees, primarily research and development personnel. AgeX has paid approximately $105,000 in accrued payroll and unused paid time off and other benefits and expects to recognize approximately $194,800 in restructuring charges in connection with the reduction in staffing, consisting of contractual severance and other employee termination benefits, substantially all of which are expected to be settled in cash. The staff reductions followed AgeXs strategic review of its operations, giving consideration to the status of its product development programs, human resources, capital needs and resources, and current conditions in the capital markets resulting from the COVID-19 pandemic.

Going Concern Considerations

As required under Accounting Standards Update 2014-15, Presentation of Financial Statements-Going Concern (ASC 205-40), AgeX evaluates whether conditions and/or events raise substantial doubt about its ability to meet its future financial obligations as they become due within one year after the date its financial statements are issued. Based on AgeXs most recent projected cash flows, and considering that loans from Juvenescence in excess of an initial $500,000 advance under the New Loan Agreement will be subject to Juvenescences discretion, AgeX believes that its cash and cash equivalents, the $500,000 loan under the New Loan Agreement, the PPP Loan and reduction in staff in May 2020 would not be sufficient to satisfy its anticipated operating and other funding requirements for the twelve months following the filing of AgeXs Quarterly Report on Form 10-Q for the three months ended March 31, 2020. These factors raise substantial doubt regarding the ability of AgeX to continue as a going concern.

First Quarter 2020 Operating Results

Revenues: Total Revenues for the first quarter of 2020 were $515,000 as compared with $388,000 for the first quarter of 2019. AgeX revenue is primarily generated from subscription and advertising revenues from the GeneCards online database through its subsidiary LifeMap Sciences, Inc. Revenues in 2020 also included approximately $86,000 of allowable expenses under its research grant from the NIH as compared with $15,000 in the same period in 2019.

Operating expenses: Operating expenses reported for the three months ended March 31, 2020 were $3.7 million as compared to $3.4 million for the same period in 2019. On an as-adjusted basis, operating expenses for the three months ended March 31, 2020 were $3.2 million as compared to $2.8 million for the same period in 2019.

The reconciliation between GAAP and non-GAAP operating expenses is provided in the financial tables included with this earnings release.

Research and development expenses increased by $0.3 million to $1.6 million during the three months ended March 31, 2020 from $1.3 million during the same period in 2019. The increase was primarily attributable to an increase of $0.2 million in scientific consultants, $0.2 million in laboratory facilities and equipment related expenses and maintenance, $0.1 million in personnel related expenses allocable to research and development, and $0.1 million in depreciation and amortization of laboratory equipment and improvements. These increases were offset to some extent by a decrease of $0.3 million in shared services from Lineage Cell Therapeutics, Inc. (Lineage) with the termination of the Shared Facilities and Services Agreement on September 30, 2019.

General and administrative expenses for the three months ended March 31, 2020 remained consistent with the same period in 2019 of $2.1 million despite bearing the full lease and facilities related costs since April 2019, and an increase in head count with the employment of AgeXs own finance team since October 1, 2019. These increases were offset by a decrease in shared facilities and services fees from Lineage following the termination of the Shared Facilities and Services Agreement on September 30, 2019.

About AgeX Therapeutics

AgeX Therapeutics, Inc. (NYSE American: AGE) is focused on developing and commercializing innovative therapeutics for human aging. Its PureStem and UniverCyte manufacturing and immunotolerance technologies are designed to work together to generate highly defined, universal, allogeneic, off-the-shelf pluripotent stem cell-derived young cells of any type for application in a variety of diseases with a high unmet medical need. AgeX has two preclinical cell therapy programs: AGEX-VASC1 (vascular progenitor cells) for tissue ischemia and AGEX-BAT1 (brown fat cells) for Type II diabetes. AgeXs revolutionary longevity platform induced Tissue Regeneration (iTR) aims to unlock cellular immortality and regenerative capacity to reverse age-related changes within tissues. AGEX-iTR1547 is an iTR-based formulation in preclinical development. HyStem is AgeXs delivery technology to stably engraft PureStem cell therapies in the body. AgeXs core product pipeline is intended to extend human healthspan. AgeX is seeking opportunities to establish licensing and collaboration arrangements around its broad IP estate and proprietary technology platforms and therapy product candidates.

For more information, please visit http://www.agexinc.com or connect with the company on Twitter, LinkedIn, Facebook, and YouTube.

Forward-Looking Statements

Certain statements contained in this release are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Any statements that are not historical fact including, but not limited to statements that contain words such as will, believes, plans, anticipates, expects, estimates should also be considered forward-looking statements. Forward-looking statements involve risks and uncertainties. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the business of AgeX Therapeutics, Inc. and its subsidiaries, particularly those mentioned in the cautionary statements found in more detail in the Risk Factors section of AgeXs most recent Annual Report on Form 10-K and Quarterly Report on Form 10-Q filed with the Securities and Exchange Commissions (copies of which may be obtained at http://www.sec.gov). Subsequent events and developments may cause these forward-looking statements to change. AgeX specifically disclaims any obligation or intention to update or revise these forward-looking statements as a result of changed events or circumstances that occur after the date of this release, except as required by applicable law.

AGEX THERAPEUTICS, INC. AND SUBSIDIARIES

CONDENSED CONSOLIDATED BALANCE SHEETS

(IN THOUSANDS, EXCEPT PAR VALUE AMOUNTS)

March 31,

2020

December 31,

2019

(Unaudited)

ASSETS

CURRENT ASSETS

Cash and cash equivalents

$

468

$

2,352

Accounts and grants receivable, net

366

363

Prepaid expenses and other current assets

1,238

1,339

Total current assets

2,072

4,054

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COVID sheds light on importance of health on the farm – Western Producer

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Farmers have always been connected to several aspects of a healthy lifestyle. As food producers, were closely connected to the lifecycle of food, from field to fork.

Were also early pioneers of the concept of community, which happens to be a primary factor for self-reported happiness. But as agriculture has evolved, have we lost aspects of health in our daily lives?

A farm business is only as healthy as its operators and neglecting a healthy lifestyle can result in a vulnerable farming operation and food supply. At the forefront of most health-related topics is physical health.

Farmers often consider themselves to be in good physical condition. Many arent anymore, notes Mike Raine, managing editor of The Western Producer.

There are many reasons for this, but many of them boil down to technology, isolation and automation.

City folks often referred to us as farmer-strong because we grew up lifting bales or twisting and bending to get under or onto equipment. It was heavier work then. The farming lifestyle that the country was built on mostly doesnt exist anymore, and now farmers need to supplement with fitness, says Raine.

Whats less obvious to many is the impact that our psychological health has overall health. And while COVID-19 has only infected a small percentage of the population, the virus that has infected nearly everyone is the virus of fear. Fear is highly contagious, and farmers arent immune.

Whether its the fear of getting sick or the fear of losing a family farming operation due to the economic downturn, this fight or flight response to danger has substantial impacts on immune response. There is strong evidence indicating that healthy individuals respond to COVID-19 more favourably than unhealthy individuals. Much of this can be traced back to the bodys psychological state, which affects the body on a biochemical level.

When we perceive stress, the body produces cortisol. Cortisol is the fight-or-flight response hormone responsible for regulating blood pressure and inflammation. During this process, the body also produces a less desirable hormone called norepinephrine, what is more commonly known as adrenaline. This hormone causes increased heart rate and blood pressure. In situations of chronic stress, the body is unable to produce cortisol and the result is unopposed norepinephrine. The link between mental and physical response to stress, whats referred to as mind-body connection, is more relevant than ever before.

Whats also less mentioned is how closely related anxiety is to asthmatic symptoms and other respiratory conditions. While mild stress can most often be managed, situations of chronic stress often results in physical ailments later on in life. Our mental state, has significant impacts on how the body responds to physical stress.

A prime example of this is the impact that the human mind can have on the outcome of major surgeries. Research has found that viewing a surgeon in a favourable light can have a positive impact on the outcome of surgery.

Certainly, fear isnt always a bad thing; doctors can also use this technique to motivate patients to make positive lifestyle changes to improve overall health.

The dominant factor responsible for increased longevity and happiness is not diet or exercise, its the feeling of being a part of a community. While farmers have always been community-based, they are also incredibly isolated in some circumstances. The possible result of this is loneliness.

Current research suggests the perception of loneliness is the greatest indicator of premature mortality, and isolation can increase this by up to 45 percent. As humans, we are hardwired to be with other humans and these social connections are one of the greatest indicators of health and happiness.

As humans, we are constantly exposed to threats in various forms. Yet somehow it seems as though we believe our health is something that will be gifted to us.

How often does an individual visit their doctor while they are actively working to stay healthy, as opposed to when a significant health-related crisis is occurring?

Arguably, COVID-19 has prompted more people to consider their own health and explore ways to improve their lifestyle. And for good reason, especially considering that many farmers take great satisfaction in having the ability to farm into their 90s.

Staying healthy is critical to our worlds food supplies and the sustainability of the family farm. Health is not merely the absence of illness, but a long-term strategy to building a more sustainable future. Healthy individuals manage profitable family farms and, as an industry, we need to support this.

Katelyn Duncan, PAg, BSA, is a Saskatchewan farmer and agrologist.

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Twenty years of power and energy engagement goes on | ESI-Africa.com – ESI Africa

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From its simple beginnings as a metering conference African Utility Week, along with its trusted official host publication ESI Africa, has spent the past two decades closely mirroring the growth of the continents energy, power and water value chains.

This article first appeared inESI AfricaIssue 2-2020.Read thefulldigimaghereorsubscribe to receive a print copy here.

As the continents water and power systems grew and became more sophisticated, the conference and exhibition expanded into one of the largest events on the continent, morphing into African Utility Week and POWERGEN Africa (AUW & PGAF).

David Ashdown, Managing Director Africa for Clarion Events, in conversation with ESI Africa chalks up AUW & PGAFs longevity to its ability to mirror the development and evolution of the market. With the expo weve done well to deliver a premium audience of professionals, representing more than 90 countries. The conference brings together a good cross section of speakers from the continent and abroad while being focused on solution-providing and knowledge-sharing, says Ashdown.

He is curious and excited to see what the future holds for AUW & PGAF as it enters its third decade. While it is too early to tell how a sudden burst of digitisation brought to the fore by the COVID-19 pandemic will affect the event industry as a whole, Ashdown thinks it isnt so much that the digital world is encroaching on live events but that the two are finding a way to blend: Clarion Events has been working across the two forms of media for the past ten years and we have seen a steady convergence. The reach we have through our digital media now culminates in live events as a meeting place.

Enforced lockdowns around the world have changed how Clarion Energys entire global workforce operates: Ultimately, we have to support the industry we serve; however, we can now provide support in the development plans of our stakeholders, to work with them to achieve real results in the power and energy sector.

It is going to be challenging, bouncing back from the pandemic crisis. Our products are well positioned and the discussions at AUW & PGAF in November will be about the resilience of the industry sector and the future outlook. How does Africa manage a crisis situation? I think the situation will accelerate the digitalisation of the sector, of the energy space in Africa and the infrastructure, smart city and IoT elements.

In terms of the traditional conference and exhibitions space, Ashdown does not foresee a move away from face-to-face engagement, as we are human; it is the way we interact.

He adds that through the events media arm, we can communicate with an industry for 365 days a year and connect industry professionals to the benefit of their business, its that element that makes us very valuable. We provide a wide range of media content through our journals platforms, which range from a webinar where individuals speak on a curated topic to a panel bringing industry experts together or a debate on a web portals news story where you can take the conversation into a whole new direction.

Webinars have a huge role to play but rather than replace a physical conference, he believes there will eventually be a blended approach a simulcast where a person who cannot travel can still participate in a virtual way to attend a live conference.

Again, Ashdown points out that one simply cannot remove the human need to connect. There are people who will take a more conservative approach in the short term and the fear and anxiety created by COVID-19 might limit peoples comfort zone. It is our responsibility as event organisers to recognise that and to bring in measures in November to create a safe space.

Is the future of event conferencing virtual, though? That is the holy grail of questions, isnt it? What is the model and what would it look like? That debate could go on for many hours and end with different conclusions. But, what you lack in a purely virtual exhibition is the human connection. A virtual handshake is not the same as President Cyril Ramaphosas elbow greeting, says Ashdown. ESI

http://www.african-utility-week.com | http://www.powergenafrica.com

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