Microscopic swimming robots that could navigate through the body to perform medical tasks such as delivery of targeted cancer therapies or surgeries are currently in development. In a study published March 24 in Science Robotics, scientists made magnetically controlled microrobots based on neutrophils, a type of white blood cell. In mice, these so-called neutrobots penetrated the blood-brain barrier (BBB) to deliver drugs to brain cancer cells.
This is a very cool idea, says Liangfang Zhang, a nanoengineer and bioengineer at the University of California, San Diego, who was not involved with the study. I would say this paper is still an early proof-of-concept study, but I think that the overall concept is novel. Its interesting because its new thinking about how to send cargo to the brain.
A major hurdle in treating neurological diseases is getting drugs past the BBB, a highly selective boundary that denies most substances admission to the brain. But certain white blood cells are granted special access to deal with infections and inflammation, making them good trojan horses for getting drugs past this blockade. In previous studies, researchers have loaded brain cancer drugs into neutrophils and macrophages, which have a natural ability to scout out cancer because they swim toward higher concentrations of inflammatory chemicals released by diseased tissue.
But prior iterations of drug-ferrying immune cells have failed to completely treat mouse brain tumors, likely due in part to slow migration to the disease site. To improve speed and control, researchers have endowed microrobots based on sperm, bacteria, or red blood cells with magnetic material to externally guide them with magnetic fields, says Zhiguang Wu, a bioengineer at the Harbin Institute of Technology in China and a coauthor of the new study.
To treat glioma, a type of brain cancer, in mice, Wu and his colleagues designed neutrophil-based microrobotsneutrobotsthat could be controlled with a magnetic field. First, the team made nanoparticles from a gel embedded with magnetic iron oxide beads and the widely used cancer drug paclitaxel. Next, the nanoparticles were enrobed in E. colibacterial membrane. Disguised as harmful bacteria, the nanoparticles were engulfed by mouse neutrophils in vitro much more readily than bare nanoparticles. The bacterial cloak also prevented the premature leakage of drugs and made the particles less toxic to the neutrophils, the researchers found.
A transmission electron microscopy image of a single neutrobot. The yellow arrow indicates a cluster of nanoparticles containing iron oxide and paclitaxel, each enclosed by an E. coli membrane. The scale bar is 2 m.
The team tested the neutrobots navigation and drug-delivery capabilities in vitro. Under the control of a rotating magnetic field, the neutrobots reached a speed of 16.4 m per second, about 50 times faster than the speed of natural neutrophils. By monitoring the neutrobots via a microscope, the researchers could direct them to move in complex orientations on an artificial substrate.
To evaluate the neutrobots inflammation-seeking ability, the researchers placed them in a gel with a concentration gradient of an inflammatory factor. The neutrobots migrated toward higher concentrations of the chemical at a speed on par with natural neutrophils. And in a model BBB, neutrobots penetrated mouse cells grown on a membrane to access glioma cells and released their drug payload upon exposure to inflammation signals.
Finally, the researchers tested whether the bots could treat brain cancer in mice. First, they injected glioma cells into mouse brains. After 10 days, they performed surgery on some of the mice to remove a portion of the tumor in order to boost neutrophil-attracting inflammatory signals. The researchers injected neutrobots into the tails of all of the mice, and in a subset of mice, they used a rotating magnetic field to direct the neutrobots toward the brain. Using magnetic resonance imaging (MRI), the team found that more neutrobots accumulated around gliomas in mice treated with both surgery and the magnetic field compared with mice that werent exposed to the magnetic field, didnt undergo surgery, or received neither. The doubly treated mice also survived longerevidence that the two interventions complemented one another. Transmission electron microscopy confirmed that neutrobots penetrated the BBB and entered glioma tissue.
All of the neutrobot-treated mice survived longer compared with animals treated with an injection of just saline or paclitaxel, indicating that neutrobots could still deliver drugs across the BBB in response to a weak inflammatory signal or a strong inflammatory signal without magnetic propulsion.
According to Zhang, the individual components of the studythe use of immune cells as drug carriers, magnetically controlled nanoparticles, and bacterial membranes as cloaksare not new. But what they did is integrate these common individual components together and assembled them into a new system, he says. They [developed] a very unique functionalitythat is, the long-range control of neutrophils.
Mariana Medina-Snchez, a bioengineer at the Leibniz Institute for Solid State and Materials Research Dresden in Germany who did not contribute to the research, says the study is valuable because it demonstrates effective treatment of tumors in vivo, a goal of many researchers in the field. [The study] is complete, its systematic, and there is strong evidence that what theyve developed is functioning, she says.
If you know the amount of the drug that you load per microrobot, you can control the drug dose by swarming these microrobots in a controlled way.
Mariana Medina-Snchez, Leibniz Institute for Solid State and Materials Research Dresden
But before microrobots can be used to treat cancer in people, there are still a number of challenges that need to be overcome. One of these is improving the percentage of microrobots that make it to the tumor. They had an accumulation of these neutrophil-based microrobots of about eleven percent in the disease site [in vivo]. So what happens with the others? says Medina-Snchez. Microrobots could accumulate in other organs or regions of the body, and the long-term side effects are unknown, she says. But this happens for every type of microrobot, not just for this particular work. This is a challenge for everyone to [overcome].
Once the microrobots arrive at the disease site, another hurdle is making sure they deliver enough of the drug. You need to increase the overall drug payload inside, and you also need to control premature drug release, says Zhang. It takes time for the neutrophil to get to the destination. You dont want to them to dump all the payload before they get to the destination.
Because a single microrobot cant carry enough medication to treat a disease, researchers are also trying to understand how they move as swarmssimilar to the collective movements of groups of ants, fish, or birds. If you know the amount of the drug that you load per microrobot, you can control the drug dose by swarming these microrobots in a controlled way, says Medina-Snchez. So this is one of the challenges: how to transport multiple [microrobots] in a controlled manner and deliver them to a target location. Wu and his colleagues found that neutrobots formed chains of four in vitro, and these swarms swam about five times faster than individual bots did. But according to Medina-Snchez, other microrobot researchers are aiming for swarms of hundreds, thousands, or even millions. It depends on the target and location, she says. You may need just a few or millions of them.
Its not clear how the neutrobots swarmed in mice because current imaging techniques arent good enough to track individual or small chains of microrobots in real time at high enough resolution in vivoanother challenge for precise navigation of these tiny drug couriers in humans.
H. Zhang et al., Dual-responsive biohybrid neutrobots for active target delivery,Sci Robot,doi:10.1126/scirobotics.aaz9519, 2021.
Read the original:
Microscopic Robots Deliver Drugs to the Brain - The Scientist
- Brief: NVIDIA's venture arm invests in autonomous weeding startup Carbon Robotics - AgFunderNews - May 11th, 2024 [May 11th, 2024]
- 7 Robotics Stocks to Bet On for Reliable AI-Powered Returns - InvestorPlace - May 11th, 2024 [May 11th, 2024]
- NSF and USDA join forces to boost innovation in agricultural robotics - Future Farming - May 11th, 2024 [May 11th, 2024]
- Meet The Swiss Start-Up Taking On The Tech Giants In Robotics And AI - Forbes - May 11th, 2024 [May 11th, 2024]
- LimX Dynamics' W1 robot can stand, walk and roll on its hind 'legs' - Interesting Engineering - May 11th, 2024 [May 11th, 2024]
- Lear Corporation's acquisition showcases the industry's use of robotics and AI for efficiency and innovation - CBT Automotive News - May 11th, 2024 [May 11th, 2024]
- OMRON and NEURA Robotics Partner to Unveil New Cognitive Robot at Automate 2024 - Automation.com - May 11th, 2024 [May 11th, 2024]
- Community briefs: Ravenswood robotics at world championship, Bike to the Library Day - The Almanac Online - May 11th, 2024 [May 11th, 2024]
- JCHS Robotics shimes at VEX World Competition | Community News - The Tomahawk - May 11th, 2024 [May 11th, 2024]
- Carbon Robotics to Help Revolutionize Farming with AI, Using Investment from NVentures - Business Wire - May 11th, 2024 [May 11th, 2024]
- Nvidia's DrEureka outperforms humans in training robotics systems - VentureBeat - May 11th, 2024 [May 11th, 2024]
- Humanoid Robots: The Next-Generation Robotic Workforce - Tech Briefs - May 11th, 2024 [May 11th, 2024]
- PHOTOS Motiva helping fund Port Arthur ISD robotics and engineering - Port Arthur News - The Port Arthur News - May 11th, 2024 [May 11th, 2024]
- Kiwanis Club of Miami helps fund McMillan MS robotics team trip - Miami's Community Newspapers - May 11th, 2024 [May 11th, 2024]
- The Interplay Between Robotics and Artificial Intelligence in Manufacturing | RoboticsTomorrow - Robotics Tomorrow - May 11th, 2024 [May 11th, 2024]
- Doosan Robotics releases its longest reach cobots with PRIME SERIES - Robot Report - May 11th, 2024 [May 11th, 2024]
- KION North America and Fox Robotics Announce Non-Exclusive Strategic Partnership - Automation.com - May 11th, 2024 [May 11th, 2024]
- Ag tech startup Carbon Robotics lands Nvidia investment - The Business Journals - May 11th, 2024 [May 11th, 2024]
- Mars Robotics offers chance to drive Mars rover on Saturday - Butler Eagle - May 11th, 2024 [May 11th, 2024]
- Comparative analysis of robot-assisted language learning systems and human tutors in English conversation lessons - EurekAlert - May 11th, 2024 [May 11th, 2024]
- Valencia College to more than double students training in semiconductors, robotics and optics - The Business Journals - May 11th, 2024 [May 11th, 2024]
- DeepMind is experimenting with a nearly indestructible robot hand - New Scientist - May 11th, 2024 [May 11th, 2024]
- Five Things to Consider Before Adopting Robotics for Warehouse Automation - Automation.com - May 11th, 2024 [May 11th, 2024]
- Nvidia and Alphabet's Intrinsic aim to revolutionize next-gen robotics - VentureBeat - May 11th, 2024 [May 11th, 2024]
- NVIDIA and Alphabet's Intrinsic Put Next-Gen Robotics Within Grasp - Automation.com - May 11th, 2024 [May 11th, 2024]
- STEM robotics team celebrates 10 years and remembers hero who saved lives - Denver 7 Colorado News - May 11th, 2024 [May 11th, 2024]
- Zero-shot learning helps Intrinsic pave the future for robotics - FierceElectronics - May 11th, 2024 [May 11th, 2024]
- EN robotics team demonstrates real-world learning | News Sun | kpcnews.com - KPCnews.com - May 11th, 2024 [May 11th, 2024]
- Future Innovators Challenged to Design Nuclear Fission and Fusion Decommissioning Robots - Automation.com - May 11th, 2024 [May 11th, 2024]
- Meet Pepper and Bernard: The robots shaping AI research at SDSU - Daily Aztec - May 11th, 2024 [May 11th, 2024]
- Gene Haas Foundation Partner Hosts FIRST Robotics District Competitions - Kettering University - May 5th, 2024 [May 5th, 2024]
- NASA Showcases Innovations at the 2024 FIRST Robotics World Championships - NASA - May 5th, 2024 [May 5th, 2024]
- Robots are invading the San Carlos Branch Library - San Diego Community Newspaper Group - May 5th, 2024 [May 5th, 2024]
- Wyoming-Based Company Makes High-Tech Robots To Go Where Humans Don't Want To - Cowboy State Daily - May 5th, 2024 [May 5th, 2024]
- Anzu Robotics launches U.S.-based clone of DJI Mavic 3 - Robot Report - May 5th, 2024 [May 5th, 2024]
- Carnegie Mellon University's Robotics Institute begins developing drones to fight wildfires - CBS Pittsburgh - May 5th, 2024 [May 5th, 2024]
- 3 Robotics Stocks That Could Be Multibaggers in the Making: Spring Edition - MSN - May 5th, 2024 [May 5th, 2024]
- Hopkinton teams advance to Robotics World Championships - Hopkinton Independent - May 5th, 2024 [May 5th, 2024]
- "Big Cat Robotics" team from Wellsville returns from VRC World Championship - THE WELLSVILLE SUN - THE WELLSVILLE SUN - May 5th, 2024 [May 5th, 2024]
- PropStream-Sponsored Robotics Team Places in Competition - RisMedia.com - May 5th, 2024 [May 5th, 2024]
- Bellefontaine Robotics Team Travels to World Championship Peak of Ohio - peakofohio.com - May 5th, 2024 [May 5th, 2024]
- ASL Aviation Holdings Inks Deal with Reliable Robotics for 30 Aircraft Autonomy Systems - Business Wire - May 5th, 2024 [May 5th, 2024]
- Global Nano Robotics Market Projected to Surge to US$ 19.86 Billion by 2032: Healthcare Trends Catalyzing Nano ... - GlobeNewswire - May 5th, 2024 [May 5th, 2024]
- 'Afghan Dreamers' | Film about Afghan girls robotics team to be screened on May 15 - Piedmont Exedra - May 5th, 2024 [May 5th, 2024]
- 3 Robotics Stocks That Could Be Multibaggers in the Making: Spring Edition - InvestorPlace - May 5th, 2024 [May 5th, 2024]
- The Rise of the Navy Robots - Signal Magazine - May 5th, 2024 [May 5th, 2024]
- Elon Musk Keeps Talking About the Future of Robotics With Optimus, but This Phenomenal Growth Stock Has Already ... - The Motley Fool - May 5th, 2024 [May 5th, 2024]
- Robosen Robotics Teams Up with Hasbro to Debut the Worlds First Auto-Converting Decepticon Megatron! - aNb Media - May 5th, 2024 [May 5th, 2024]
- John P. Stevens Robotics Team Wins Excellence in Technology at Innovators Awards - TAPinto.net - May 5th, 2024 [May 5th, 2024]
- Nala Robotics and Re-Up partner to develop AI-powered robotic chef - Robotics and Automation News - May 5th, 2024 [May 5th, 2024]
- LCSD1 to Host Final Robotics Competition of the School Year Tomorrow - The Cheyenne Post - May 5th, 2024 [May 5th, 2024]
- GMV showcases its robotic inspection capabilities Robotics & Automation News - Robotics and Automation News - May 5th, 2024 [May 5th, 2024]
- Trine's armored robot finishes 4th in national combat - Trine University - May 5th, 2024 [May 5th, 2024]
- Female robotics founders discuss their journeys in the industry - Robot Report - May 5th, 2024 [May 5th, 2024]
- Hanwha Robotics, B-Robotics join hands on restaurant automation project - Aju Press - May 5th, 2024 [May 5th, 2024]
- Dishchii'bikoh Community School Robotics Team Heads to VEX World Championship - White Mountain Independent - May 5th, 2024 [May 5th, 2024]
- ETH unveils space-hopping robot for asteroid exploration - Robotics and Automation News - May 5th, 2024 [May 5th, 2024]
- Nickelytics and Starship release robots at UCLA and Utah universities - Robotics and Automation News - May 1st, 2024 [May 1st, 2024]
- Next-Level Robotics: Enhancing Accuracy with Advanced Multisensory Interfaces - AZoRobotics - May 1st, 2024 [May 1st, 2024]
- Death of Lake Orion teen on robotics trip determined to be suicide, Houston police say - Detroit News - May 1st, 2024 [May 1st, 2024]
- Niqo Robotics Raises $9 Million In Funding Round Led By Brida Innovation Ventures: Report - Outlook India - May 1st, 2024 [May 1st, 2024]
- Mission to 'Holy Grail of Shipwrecks' Will Employ Robotics - USNI News - May 1st, 2024 [May 1st, 2024]
- Kiwibot acquires Auto Mobility Solutions Robotics & Automation News - Robotics and Automation News - May 1st, 2024 [May 1st, 2024]
- Untethered soft actuators for soft standalone robotics - Nature.com - May 1st, 2024 [May 1st, 2024]
- Robotics in the restaurant industry are here to stay: Carlos Gazitua - Fox Business - May 1st, 2024 [May 1st, 2024]
- It's time for UK business to embrace robotics - Design Products & Applications - May 1st, 2024 [May 1st, 2024]
- Meet the `One Percenters' - The Top Ranked Robotics Group from Franklin - Franklin Observer - May 1st, 2024 [May 1st, 2024]
- Atlas, forefather of humanoid robots, gives way to next generation - Marketplace - May 1st, 2024 [May 1st, 2024]
- BlueBotics releases new version of its server fleet management software - Robotics and Automation News - May 1st, 2024 [May 1st, 2024]
- U.S. manufacturers invested heavily in robotics in 2023, finds IFR - Robot Report - May 1st, 2024 [May 1st, 2024]
- This is a unique time: ARK Invests chief futurist tackles tech innovation from AI to robotics - CNBC - May 1st, 2024 [May 1st, 2024]
- U.S. Companies Invest Heavily in Robots - IFR Preliminary Results EMSNow - EMSNow - May 1st, 2024 [May 1st, 2024]
- MiR launches new autonomous mobile forklift-type robot - Robotics and Automation News - May 1st, 2024 [May 1st, 2024]
- Rutland Area Robotics' IBOTS compete in FIRST World Championships finals for first time - Rutland Herald - May 1st, 2024 [May 1st, 2024]
- Micropsi Industries introduces new AI-vision software Robotics & Automation News - Robotics and Automation News - May 1st, 2024 [May 1st, 2024]
- Robots on a Roll: The Future of Farming Is Here Now - Growing Produce - May 1st, 2024 [May 1st, 2024]
- Grand Force, Grand Forks' only FIRST Robotics team, returns from world championship with good memories - Grand Forks Herald - May 1st, 2024 [May 1st, 2024]
- Reston Robotics Team Wins National Competition At Tech Conference - Patch - May 1st, 2024 [May 1st, 2024]
- CapSen Robotics Introduces CapSen PiC 2.0 Bin-Picking Software - Supply and Demand Chain Executive - May 1st, 2024 [May 1st, 2024]
- Gecko Robotics and Al Masaood Energy Partner to Help ADNOC Gas Revolutionize Asset Operations and ... - Business Wire - May 1st, 2024 [May 1st, 2024]