New York Stem Cell Foundation (NYSCF) Research Institute collaborates with Google Research to identify new cellular characteristics of disease in skin cells from Parkinsons patients.
A study published today (March 25, 2022) in Nature Communications unveils a new platform for discovering cellular signatures of disease that integrates robotic systems for studying patient cells with artificial intelligence methods for image analysis. Using their automated cell culture platform, scientists at the NYSCF Research Institute collaborated with Google Research to successfully identify new cellular hallmarks of Parkinsons disease by creating and profiling over a million images of skin cells from a cohort of 91 patients and healthy controls.
Traditional drug discovery isnt working very well, particularly for complex diseases like Parkinsons, noted NYSCF CEO Susan L. Solomon, JD. The robotic technology NYSCF has built allows us to generate vast amounts of data from large populations of patients, and discover new signatures of disease as an entirely new basis for discovering drugs that actually work.
This is an ideal demonstration of the power of artificial intelligence for disease research, added Marc Berndl, Software Engineer at Google Research. We have had a very productive collaboration with NYSCF, especially because their advanced robotic systems create reproducible data that can yield reliable insights.
The study leveraged NYSCFs vast repository of patient cells and state-of-the-art robotic system The NYSCF Global Stem Cell Array to profile images of millions of cells from 91 Parkinsons patients and healthy controls. Scientists used the Array to isolate and expand skin cells called fibroblasts from skin punch biopsy samples, label different parts of these cells with a technique called Cell Painting, and create thousands of high-content optical microscopy images. The resulting images were fed into an unbiased, artificial intelligencedriven image analysis pipeline, identifying image features specific to patient cells that could be used to distinguish them from healthy controls.
These artificial intelligence methods can determine what patient cells have in common that might not be otherwise observable, said Samuel J. Yang, Research Scientist at Google Research. Whats also important is that the algorithms are unbiased they do not rely on any prior knowledge or preconceptions about Parkinsons disease, so we can discover entirely new signatures of disease.
The need for new signatures of Parkinsons is underscored by the high failure rates of recent clinical trials for drugs discovered based on specific disease targets and pathways believed to be drivers of the disease. The discovery of these novel disease signatures using unbiased methods, especially across patient populations, has value for diagnostics and drug discovery, even revealing new distinctions between patients.
Excitingly, we were able to distinguish between images of patient cells and healthy controls, and between different subtypes of the disease, noted Bjarki Johannesson, PhD, a NYSCF Senior Investigator on the study. We could even predict fairly accurately which donor a sample of cells came from.
The Parkinsons disease signatures identified by the team can now be used as a basis for conducting drug screens on patient cells, to discover which drugs can reverse these features. The study also yields the largest known Cell Painting dataset (48TB) as a community resource, and is available to the research community (https://nyscf.org/nyscf-adpd/).
Notably, the platform is disease-agnostic, only requiring easily accessible skin cells from patients. It can also be applied to other cell types, including derivatives of induced pluripotent stem cells that NYSCF creates to model a variety of diseases. The researchers are thus hopeful that their platform can open new therapeutic avenues for many diseases where traditional drug discovery has been unsuccessful.
This is the first tool to successfully identify disease features with this much precision and sensitivity, said NYSCF Senior Vice President of Discovery and Platform Development Daniel Paull, PhD. Its power for identifying patient subgroups has important implications for precision medicine and drug development across many intractable diseases.
Reference: Integrating deep learning and unbiased automated high-content screening to identify complex disease signatures in human fibroblasts 25 March 2022, Nature Communications.DOI: 10.1038/s41467-022-28423-4
About The New York Stem Cell Foundation Research Institute
The New York Stem Cell Foundation (NYSCF) Research Institute is an independent non-profit organization accelerating cures and better treatments for patients through stem cell research. The NYSCF global community includes over 200 researchers at leading institutions worldwide, including the NYSCF Druckenmiller Fellows, the NYSCF Robertson Investigators, the NYSCF Robertson Stem Cell Prize Recipients, and NYSCF Research Institute scientists and engineers. The NYSCF Research Institute is an acknowledged world leader in stem cell research and in the development of pioneering stem cell technologies, including the NYSCF Global Stem Cell Array, which is used to create cell lines for laboratories around the globe. NYSCF focuses on translational research in an accelerator model designed to overcome barriers that slow discovery and replace silos with collaboration.
Excerpt from:
- Brief: NVIDIA's venture arm invests in autonomous weeding startup Carbon Robotics - AgFunderNews - May 11th, 2024 [May 11th, 2024]
- 7 Robotics Stocks to Bet On for Reliable AI-Powered Returns - InvestorPlace - May 11th, 2024 [May 11th, 2024]
- NSF and USDA join forces to boost innovation in agricultural robotics - Future Farming - May 11th, 2024 [May 11th, 2024]
- Meet The Swiss Start-Up Taking On The Tech Giants In Robotics And AI - Forbes - May 11th, 2024 [May 11th, 2024]
- LimX Dynamics' W1 robot can stand, walk and roll on its hind 'legs' - Interesting Engineering - May 11th, 2024 [May 11th, 2024]
- Lear Corporation's acquisition showcases the industry's use of robotics and AI for efficiency and innovation - CBT Automotive News - May 11th, 2024 [May 11th, 2024]
- OMRON and NEURA Robotics Partner to Unveil New Cognitive Robot at Automate 2024 - Automation.com - May 11th, 2024 [May 11th, 2024]
- Community briefs: Ravenswood robotics at world championship, Bike to the Library Day - The Almanac Online - May 11th, 2024 [May 11th, 2024]
- JCHS Robotics shimes at VEX World Competition | Community News - The Tomahawk - May 11th, 2024 [May 11th, 2024]
- Carbon Robotics to Help Revolutionize Farming with AI, Using Investment from NVentures - Business Wire - May 11th, 2024 [May 11th, 2024]
- Nvidia's DrEureka outperforms humans in training robotics systems - VentureBeat - May 11th, 2024 [May 11th, 2024]
- Humanoid Robots: The Next-Generation Robotic Workforce - Tech Briefs - May 11th, 2024 [May 11th, 2024]
- PHOTOS Motiva helping fund Port Arthur ISD robotics and engineering - Port Arthur News - The Port Arthur News - May 11th, 2024 [May 11th, 2024]
- Kiwanis Club of Miami helps fund McMillan MS robotics team trip - Miami's Community Newspapers - May 11th, 2024 [May 11th, 2024]
- The Interplay Between Robotics and Artificial Intelligence in Manufacturing | RoboticsTomorrow - Robotics Tomorrow - May 11th, 2024 [May 11th, 2024]
- Doosan Robotics releases its longest reach cobots with PRIME SERIES - Robot Report - May 11th, 2024 [May 11th, 2024]
- KION North America and Fox Robotics Announce Non-Exclusive Strategic Partnership - Automation.com - May 11th, 2024 [May 11th, 2024]
- Ag tech startup Carbon Robotics lands Nvidia investment - The Business Journals - May 11th, 2024 [May 11th, 2024]
- Mars Robotics offers chance to drive Mars rover on Saturday - Butler Eagle - May 11th, 2024 [May 11th, 2024]
- Comparative analysis of robot-assisted language learning systems and human tutors in English conversation lessons - EurekAlert - May 11th, 2024 [May 11th, 2024]
- Valencia College to more than double students training in semiconductors, robotics and optics - The Business Journals - May 11th, 2024 [May 11th, 2024]
- DeepMind is experimenting with a nearly indestructible robot hand - New Scientist - May 11th, 2024 [May 11th, 2024]
- Five Things to Consider Before Adopting Robotics for Warehouse Automation - Automation.com - May 11th, 2024 [May 11th, 2024]
- Nvidia and Alphabet's Intrinsic aim to revolutionize next-gen robotics - VentureBeat - May 11th, 2024 [May 11th, 2024]
- NVIDIA and Alphabet's Intrinsic Put Next-Gen Robotics Within Grasp - Automation.com - May 11th, 2024 [May 11th, 2024]
- STEM robotics team celebrates 10 years and remembers hero who saved lives - Denver 7 Colorado News - May 11th, 2024 [May 11th, 2024]
- Zero-shot learning helps Intrinsic pave the future for robotics - FierceElectronics - May 11th, 2024 [May 11th, 2024]
- EN robotics team demonstrates real-world learning | News Sun | kpcnews.com - KPCnews.com - May 11th, 2024 [May 11th, 2024]
- Future Innovators Challenged to Design Nuclear Fission and Fusion Decommissioning Robots - Automation.com - May 11th, 2024 [May 11th, 2024]
- Meet Pepper and Bernard: The robots shaping AI research at SDSU - Daily Aztec - May 11th, 2024 [May 11th, 2024]
- Gene Haas Foundation Partner Hosts FIRST Robotics District Competitions - Kettering University - May 5th, 2024 [May 5th, 2024]
- NASA Showcases Innovations at the 2024 FIRST Robotics World Championships - NASA - May 5th, 2024 [May 5th, 2024]
- Robots are invading the San Carlos Branch Library - San Diego Community Newspaper Group - May 5th, 2024 [May 5th, 2024]
- Wyoming-Based Company Makes High-Tech Robots To Go Where Humans Don't Want To - Cowboy State Daily - May 5th, 2024 [May 5th, 2024]
- Anzu Robotics launches U.S.-based clone of DJI Mavic 3 - Robot Report - May 5th, 2024 [May 5th, 2024]
- Carnegie Mellon University's Robotics Institute begins developing drones to fight wildfires - CBS Pittsburgh - May 5th, 2024 [May 5th, 2024]
- 3 Robotics Stocks That Could Be Multibaggers in the Making: Spring Edition - MSN - May 5th, 2024 [May 5th, 2024]
- Hopkinton teams advance to Robotics World Championships - Hopkinton Independent - May 5th, 2024 [May 5th, 2024]
- "Big Cat Robotics" team from Wellsville returns from VRC World Championship - THE WELLSVILLE SUN - THE WELLSVILLE SUN - May 5th, 2024 [May 5th, 2024]
- PropStream-Sponsored Robotics Team Places in Competition - RisMedia.com - May 5th, 2024 [May 5th, 2024]
- Bellefontaine Robotics Team Travels to World Championship Peak of Ohio - peakofohio.com - May 5th, 2024 [May 5th, 2024]
- ASL Aviation Holdings Inks Deal with Reliable Robotics for 30 Aircraft Autonomy Systems - Business Wire - May 5th, 2024 [May 5th, 2024]
- Global Nano Robotics Market Projected to Surge to US$ 19.86 Billion by 2032: Healthcare Trends Catalyzing Nano ... - GlobeNewswire - May 5th, 2024 [May 5th, 2024]
- 'Afghan Dreamers' | Film about Afghan girls robotics team to be screened on May 15 - Piedmont Exedra - May 5th, 2024 [May 5th, 2024]
- 3 Robotics Stocks That Could Be Multibaggers in the Making: Spring Edition - InvestorPlace - May 5th, 2024 [May 5th, 2024]
- The Rise of the Navy Robots - Signal Magazine - May 5th, 2024 [May 5th, 2024]
- Elon Musk Keeps Talking About the Future of Robotics With Optimus, but This Phenomenal Growth Stock Has Already ... - The Motley Fool - May 5th, 2024 [May 5th, 2024]
- Robosen Robotics Teams Up with Hasbro to Debut the Worlds First Auto-Converting Decepticon Megatron! - aNb Media - May 5th, 2024 [May 5th, 2024]
- John P. Stevens Robotics Team Wins Excellence in Technology at Innovators Awards - TAPinto.net - May 5th, 2024 [May 5th, 2024]
- Nala Robotics and Re-Up partner to develop AI-powered robotic chef - Robotics and Automation News - May 5th, 2024 [May 5th, 2024]
- LCSD1 to Host Final Robotics Competition of the School Year Tomorrow - The Cheyenne Post - May 5th, 2024 [May 5th, 2024]
- GMV showcases its robotic inspection capabilities Robotics & Automation News - Robotics and Automation News - May 5th, 2024 [May 5th, 2024]
- Trine's armored robot finishes 4th in national combat - Trine University - May 5th, 2024 [May 5th, 2024]
- Female robotics founders discuss their journeys in the industry - Robot Report - May 5th, 2024 [May 5th, 2024]
- Hanwha Robotics, B-Robotics join hands on restaurant automation project - Aju Press - May 5th, 2024 [May 5th, 2024]
- Dishchii'bikoh Community School Robotics Team Heads to VEX World Championship - White Mountain Independent - May 5th, 2024 [May 5th, 2024]
- ETH unveils space-hopping robot for asteroid exploration - Robotics and Automation News - May 5th, 2024 [May 5th, 2024]
- Nickelytics and Starship release robots at UCLA and Utah universities - Robotics and Automation News - May 1st, 2024 [May 1st, 2024]
- Next-Level Robotics: Enhancing Accuracy with Advanced Multisensory Interfaces - AZoRobotics - May 1st, 2024 [May 1st, 2024]
- Death of Lake Orion teen on robotics trip determined to be suicide, Houston police say - Detroit News - May 1st, 2024 [May 1st, 2024]
- Niqo Robotics Raises $9 Million In Funding Round Led By Brida Innovation Ventures: Report - Outlook India - May 1st, 2024 [May 1st, 2024]
- Mission to 'Holy Grail of Shipwrecks' Will Employ Robotics - USNI News - May 1st, 2024 [May 1st, 2024]
- Kiwibot acquires Auto Mobility Solutions Robotics & Automation News - Robotics and Automation News - May 1st, 2024 [May 1st, 2024]
- Untethered soft actuators for soft standalone robotics - Nature.com - May 1st, 2024 [May 1st, 2024]
- Robotics in the restaurant industry are here to stay: Carlos Gazitua - Fox Business - May 1st, 2024 [May 1st, 2024]
- It's time for UK business to embrace robotics - Design Products & Applications - May 1st, 2024 [May 1st, 2024]
- Meet the `One Percenters' - The Top Ranked Robotics Group from Franklin - Franklin Observer - May 1st, 2024 [May 1st, 2024]
- Atlas, forefather of humanoid robots, gives way to next generation - Marketplace - May 1st, 2024 [May 1st, 2024]
- BlueBotics releases new version of its server fleet management software - Robotics and Automation News - May 1st, 2024 [May 1st, 2024]
- U.S. manufacturers invested heavily in robotics in 2023, finds IFR - Robot Report - May 1st, 2024 [May 1st, 2024]
- This is a unique time: ARK Invests chief futurist tackles tech innovation from AI to robotics - CNBC - May 1st, 2024 [May 1st, 2024]
- U.S. Companies Invest Heavily in Robots - IFR Preliminary Results EMSNow - EMSNow - May 1st, 2024 [May 1st, 2024]
- MiR launches new autonomous mobile forklift-type robot - Robotics and Automation News - May 1st, 2024 [May 1st, 2024]
- Rutland Area Robotics' IBOTS compete in FIRST World Championships finals for first time - Rutland Herald - May 1st, 2024 [May 1st, 2024]
- Micropsi Industries introduces new AI-vision software Robotics & Automation News - Robotics and Automation News - May 1st, 2024 [May 1st, 2024]
- Robots on a Roll: The Future of Farming Is Here Now - Growing Produce - May 1st, 2024 [May 1st, 2024]
- Grand Force, Grand Forks' only FIRST Robotics team, returns from world championship with good memories - Grand Forks Herald - May 1st, 2024 [May 1st, 2024]
- Reston Robotics Team Wins National Competition At Tech Conference - Patch - May 1st, 2024 [May 1st, 2024]
- CapSen Robotics Introduces CapSen PiC 2.0 Bin-Picking Software - Supply and Demand Chain Executive - May 1st, 2024 [May 1st, 2024]
- Gecko Robotics and Al Masaood Energy Partner to Help ADNOC Gas Revolutionize Asset Operations and ... - Business Wire - May 1st, 2024 [May 1st, 2024]