Category Archives: Tms

Indias credit card spending is back with a bang. It has risen consecutively for four months now. And, helped by the festive season, it crossed the Rs 80,000-crore mark in September. What is driving the overall surge? Is that indicative of a quick recovery for the larger economy? What are the lessons we can draw from this trend? Reliance Jios smartphone JioPhone Next was expected to be a disruptor that would help the company wrest control of a majority of the remaining 300 million 2G users in India. However, the phones price is a little higher than was expected, leaving analysts a tad sceptical about the smartphones potential.

Can JioPhone Next live up to its hype? A spectacular Samvat 2077 saw the Sensex playing down all the anxieties surrounding the pandemic and surging past the 62,000 mark for the first time. The Nifty also surpassed the 18,000 mark. As the year draws to a close, we take a look at how the markets fared this Samvat, which sectors sparkled on bourses, and what may be the road ahead for markets? Ethical hacking is quite a popular term now. Ethical hackers abound in real life and in fiction. But, what exactly is ethical hacking? How is it different from the other hacking we are hear about generally? Listen to these and more in todays Business Standard Morning Show podcast.

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TMS, Ep 35: Credit card spend, JioPhone Next, markets and ethical hacking - Business Standard

(CPT is a registered trademark of the American Medical Association (AMA))

Changes include: 1) the addition of a Category I CPT code 989X6 to report Remote Therapeutic Monitoring device supply to monitor CBT; 2) revisions to the RTM-TMS guidelines to clarify reporting of CBT; and 3) the deletion of Category III CPT codes 0X47T (permanent code 0702T to report therapeutic monitoring of a standardized online digital CBT program) and 0X81T (permanent code 0703T to report the associated management services).

These revisions, which will go into effect as of January 1, 2023, will allow for the reporting of CBT monitoring services as part of RTM/RTM-TMS on a monthly basis. Meanwhile, Category I RTM/RTM-TMS CPT codes that describe services related to remote monitoring of therapy adherence and therapy response, will be available starting on January 1, 2022.

In some instances, providers may elect to use remote monitoring to help manage patients receiving remote therapy through digital medical tools like Pears FDA-authorized PDTs including reSET, reSET-O, and Somryst that deliver treatment of substance use disorder, opioid use disorder, and chronic insomnia, respectively, including the healthcare providers ability to remotely monitor therapeutic progress.

BOSTON, November 04, 2021--(BUSINESS WIRE)--Pear Therapeutics, Inc. is pleased to share that the American Medical Association (AMA) Current Procedural Terminology (CPT) Editorial Panel has announced revisions to existing CPT codes clarifying the coding of remote therapeutic monitoring for cognitive behavioral therapy (CBT) services. These changes include: 1) the addition of CPT code 989X6 to report Remote Therapeutic Monitoring device supply to monitor CBT; 2) revisions to the Remote Therapeutic Monitoring (RTM) and Remote Therapeutic Monitoring Treatment Management Services (RTM-TMS) guidelines to clarify reporting of CBT; and 3) the deletion of Category III CPT codes 0X47T (permanent code 0702T to report therapeutic monitoring of a standardized online digital cognitive behavioral therapy program) and 0X81T (permanent code 0703T to report the associated management services).

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These changes have an effective date of January 2023 CPTs Summary of Panel Actions for September-October 2021 may be found here: https://www.ama-assn.org/system/files/september-october-2021-summary-of-panel-actions.pdf.

Meanwhile, Category 1 RTM and RTM-TMS CPT codes, which were first announced in 2020, will be available starting on January 1, 2022, to describe physician and other qualified healthcare professional work including monitoring therapy adherence and response. These codes may be applicable to the work of HCPs monitoring therapy adherence and therapy response with respect to Pears commercially available PDTs, reSET, reSET-O and Somryst for the treatment of substance use disorder, opioid use disorder, and chronic insomnia, respectively, including the healthcare providers ability to remotely monitor progress.

Appropriate billing and coding for healthcare services are the providers responsibility and should always be based on the patients clinical condition, services provided, and payer guidelines. A comprehensive review of all recent changes related to remote therapeutic monitoring is recommended.

"AMAs clarifications and addition to codes describing services related to clinician monitoring of FDA-authorized medical devices delivering Cognitive Behavioral Therapy (CBT) are another significant milestone in providing coding for healthcare providers across the United States," said Corey McCann, M.D., Ph.D., President and Chief Executive Officer of Pear Therapeutics. "Ultimately, RTM Category 1 codes will provide additional CPT coding options for healthcare providers when using digital health technologies."

On October 29, 2021, AMA released the CPT Editorial Summary of Panel Actions (https://www.ama-assn.org/system/files/september-october-2021-summary-of-panel-actions.pdf), which reflects the discussion at the most recent CPT Editorial Panel meeting in September 2021. CPT coding serves as a uniform nomenclature used for medical services to improve harmonization of reporting, increase the accuracy of medical services and procedures, and to improve efficiency across healthcare. CPT terminology is the most widely accepted medical language for public and private health insurance programs. The CPT Editorial Panel is tasked with maintaining an open process that convenes meetings to solicit input from stakeholders across healthcare.

AMA announced their CPT Editorial Panel accepted the addition of code 989X6 to report remote therapeutic monitoring device supply to monitor cognitive behavioral therapy; the revision of the Remote Therapeutic Monitoring Services guidelines and the Remote Therapeutic Monitoring Treatment Management Services guidelines (CPT code family 98975, 98976, 98977, 98980, and 98981) to clarify reporting of cognitive behavioral therapy; and the deletion of codes 0X47T, 0X81T (now permanent codes 0702T and 0703T).

PDTs are a new therapeutic class that use software to treat serious disease. Like traditional medicines, PDTs are developed in a Good Manufacturing Practices (GMP) compliant environment, tested in randomized controlled trials to demonstrate safety and effectiveness, evaluated for authorization by regulators like FDA, and used under the supervision of a prescribing clinician. Pears PDTs are designed to collect real world data for use by prescribing clinicians and for population health management by payers and health systems.

About Pear Therapeutics

Pear Therapeutics is the leader in prescription digital therapeutics, or PDTs. Pear aims to redefine medicine by discovering, developing, and delivering clinically validated software-based therapeutics to provide better outcomes for patients, smarter engagement and tracking tools for clinicians, and cost-effective solutions for payers. Pear has a portfolio of products and product candidates across therapeutic areas, including the first three PDTs with disease treatment claims from FDA. Pears lead product, reSET, for the treatment of substance use disorder, was the first PDT to receive marketing authorization from FDA to treat disease. Pears second product, reSET-O, for the treatment of opioid use disorder, was the first PDT to receive Breakthrough Designation. Pears third product, Somryst, for the treatment of chronic insomnia, was the first PDT submitted through FDAs traditional 510(k) pathway while simultaneously reviewed through FDAs Software Precertification Pilot Program. For more information, visit Pear at http://www.peartherapeutics.com.

reSET Important Safety Information

Indications for Use:

reSET is intended to provide cognitive behavioral therapy, as an adjunct to a contingency management system, for patients 18 years of age and older, who are currently enrolled in outpatient treatment under the supervision of a clinician. reSET is indicated as a 12-week (90 day) prescription-only treatment for patients with substance use disorder (SUD), who are not currently on opioid replacement therapy, who do not abuse alcohol solely, or who do not abuse opioids as their primary substance of abuse.

It is intended to:

increase abstinence from a patients substances of abuse during treatment, and

increase retention in the outpatient treatment program.

Important Safety Information for Clinicians:

Warnings: reSET is intended for patients whose primary language is English with a reading level of 7th grade or above, and who have access to an Android/iOS tablet or smartphone. reSET is intended only for patients who own a smartphone and are familiar with use of smartphone apps (applications).

Clinicians should not use reSET to communicate with their patients about emergency medical issues. Patients should be clearly instructed not to use reSET to communicate to their clinician any urgent or emergent information. In case of an emergency, patients should dial 911 or go to the nearest emergency room.

reSET is not intended to be used as a stand-alone therapy for substance use disorder (SUD). reSET does not replace care by a licensed medical practitioner and is not intended to reduce the amount of face-to-face clinician time. reSET does not represent a substitution for a patients medication. Patients should continue to take their medications as directed by their healthcare provider.

Patients with substance use disorder experience mental health disease and co-morbid medical problems at higher rates than the general population. Patients with substance use disorder also have higher baseline rates of suicidal ideation, and suicide attempts, and suicide completion. Clinicians should engage in their normal care practices to monitor patients for medical problems and mental health disorders, including risk for harming others and/or themselves.

The long-term benefit of treatment with reSET on abstinence has not been evaluated in studies lasting beyond 12 weeks (90 days) in the SUD population. The ability of reSET to prevent potential relapse after treatment discontinuation has not been studied.

The effectiveness of reSET has not been demonstrated in patients currently reporting opioids as their primary substance of abuse.

This Press Release does not include all the information needed to use reSET safely and effectively. Please see the Clinician Brief Summary for reSET for more information.

reSET-O Important Safety Information

Indications for Use:

reSET-O prescription digital therapeutic is a 12-week (84 day) software application intended to increase retention of patients with opioid use disorder (OUD) in outpatient treatment by providing cognitive behavioral therapy, as an adjunct to outpatient treatment that includes transmucosal buprenorphine and contingency management, for patients 18 years or older who are currently under the supervision of a clinician. reSET-O is indicated as a prescription-only digital therapeutic.

Important Safety Information for Clinicians:

Warnings: reSET-O is intended for patients whose primary language is English with a reading level of 7th grade or above, and who have access to an Android/iOS tablet or smartphone. reSET-O is intended only for patients who own a smartphone and are familiar with use of smartphone apps (applications).

Clinicians should not use reSET-O to communicate with their patients about emergency medical issues. Patients should be clearly instructed not to use reSET-O to communicate to their clinician any urgent or emergent information. In case of an emergency, patients should dial 911 or go to the nearest emergency room.

reSET-O is not intended to be used as a stand-alone therapy for Opioid Use Disorder (OUD). reSET-O does not replace care by a licensed medical practitioner and is not intended to reduce the frequency or duration of in-person therapy. reSET-O does not represent a substitution for a patients medication. Patients should continue to take their medications as directed by their healthcare provider.

Patients with opioid use disorder experience mental health disease and co-morbid medical problems at higher rates than the general population. Patients with opioid use disorder have higher baseline rates of suicidal ideation, and suicide attempts, and suicide completion. Clinicians should undertake standard of care to monitor patients for medical problems and mental health disease, including risk for harming others and/or themselves.

The long-term benefit of reSET-O has not been evaluated in studies lasting beyond 12 weeks (84 days) in the OUD population. The ability of reSET-O to prevent potential relapse after therapy discontinuation has not been studied.

This Press Release does not include all the information needed to use reSET-O safely and effectively. Please see the Clinician Brief Summary Instructions for reSET-O for more information.

Somryst Important Safety Information

Indications for Use

Somryst is a prescription-only digital therapeutic intended to provide a neurobehavioral intervention (Cognitive Behavioral Therapy for Insomnia CBT-I) to patients 22 years of age and older with chronic insomnia. Somryst treats patients with chronic insomnia by improving a patients insomnia symptoms.

Important Safety Information:

Warnings: Somryst is not for everyone. Please use your clinical judgement to determine whether Somryst is right for your patient.

Somryst is not for emergency use. Please instruct patients to dial 911 or to go to the nearest emergency room in the event of a medical emergency,

Patients should be clearly instructed not to use Somryst to communicate severe, critical, or urgent information to their Health Care Provider.

Somryst is not meant to be used as treatment without supervision of a Health Care Provider.

Somryst is not meant to be a substitution for any treatment medication.

Somryst contains sensitive medical information. Please instruct patients to protect their information by password-protecting their smartphone and tablet, ensuring no one else may access their device.

Sleep Restriction (and Consolidation) within Somryst can cause sleepiness, especially in the early stages of using the PDT. Somryst should not be used if the patient needs to be alert or cautious to avoid serious accidents in their job or daily life. Examples include:

The usage data collected in therapy lessons by Somryst are not intended to be used as a standalone assessment of treatment progress.

This press release does not include all the information needed to use Somryst safely and effectively. Please see the full Clinician Brief Summary Instructions for Somryst for more information.

View source version on businesswire.com: https://www.businesswire.com/news/home/20211104005650/en/

Contacts

Media and Investors: Meara MurphySenior Director, Corporate Communicationsmeara.murphy@peartherapeutics.com

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Pear Therapeutics Announces Milestone Decision by the American Medical Association CPT Editorial Panel to Clarify the Coding of Remote Therapeutic...

HARRISON COUNTY, Ohio (WTRF) When veterans return home from combat, sometimes theyre left with more than memories.That can be a physical injury or a mental scar that we cant see, but wont go away.

But, what happens when a veteran feels like theres no help left?

22 veterans a day commit suicide.

Inside a small room in Harrison County, theyre taking the first steps to reduce that number.

Were trained in the military to suck it up and drive on and its a good concept in battle.

However, its not always when it comes to readjusting from combat to the comforts of home.

30 days. Thats a very short amount of time to get the rest of your life back.

The dull humming of the TMS machines inside a small room at the Harrison County Sheriffs Office is a welcome noise to area veterans.

What theyre doing is kinda pressing control alt delete in the brain and were re-booting it. Were slowing the neurons down or speeding them so that both sides of the brain are working at their optimum level.

Its called transcranial magnetic stimulation and its helping veterans with PTSD, brain injuries, and much more.

TMS works with a magnet. Those wishing to receive the treatment get an initial EEG to test how their brain waves are functioning. Then, that number is sent to a treatment center in California. The time and intensity of the treatments is adjusted based on each persons unique brain rhythm with guidance from the treatment center.

About 35 veterans have completed the program in Harrison County. It takes 30 minutes a day, five days a week for six weeks for a total of 30 treatments.

I felt a tingle go down my hands and Ive never been able to close my hands for years and years and right then I closed a complete fist without any problem.

Terry Fabry of Smithfield is a Vietnam veteran. When 7News spoke to him, he only had one more session left to finish his TMS treatment. Before it helped improve his life, Fabry had trouble sleeping and was in pain most of the time.

When I was over there I fell down a mountain and I was carrying a radio and I had my M-79, which carries 68 rounds and it was a lot of weight. When I fell down the mountain I fell probably 20, 30 feet and I rolled into a cave and screwed up my neck, my lower back and my ankle. Everything from that time hasnt been good.

Fabry said he saw results after the first session.

I am proud of what I did. I did what I thought I should do at the time and Ive just had to live with the aftermath.

Roy Stewart is a Vietnam veteran who lives in St. Clairsville.

He said hes struggled mentally for years, especially with sleep after his wife died.His stepson, also a veteran, sustained a head injury during service.

I am sleeping better. I havent quite got all the way yet, because Im starting my third treatment now, but its worth it because I feel better and my stepsons doing better.

Spend time with the group that frequently gathers at the Harrison County Sheriffs Office and theyll tell you how much TMS changed their lives.

Its not just for veterans. The treatment is FDA approved for headaches and anxiety.

There are around 50 of these TMS machines in the world, and two of them reside in Harrison County. People from 11-years-old all the way to 93-years-old have gotten the treatments.

I feel like this has made me more at ease. Its made me more comfortable.

Dirk Harkins sets up these machines five days a week.He works so hard to help others because he knows how TMS can change a life.

I found myself in a high-speed chase with local law enforcement agencies and I pulled over and tried suicide by cop at that time.

In this Digital Exclusive, hear veteran Dirk Harkins describe the difficult journey after an injury and PTSD diagnosis that lead him to TMS treatments and how they changed his life.

Harkins served in the Army in the 82nd Airborne and was injured in 2007 when a Humvee he was riding in was hit with an IED. He suffered back, neck and hip injuries, was diagnosed with a traumatic brain injury (TBI) and PTSD. Harkins returned home and was never the same.

He was stuck in a days-long depression, after years of struggles with opioids and alcohol and Harkins recalls he was at the end of his rope.

After seeking help at the V.A. and told to come back in a few days, he found himself in that encounter with police and eventually in jail. There Harkins called his friend, Ohio State Senator Frank Hoagland, who got him into TMS treatments in Texas for six months.

For 12 years I was having a headache every single day at one level or another I would wake up with a headache. Throughout the week I would probably have two to three maybe four migraines where they would put me down and Id have to rely on medication and sleep to try and get rid of these migraine headaches, but after the fourth treatment I woke up for the first time in 12 years and didnt have a headache. If that was all that happened to me I would of come back to Ohio excited, you know what I mean, but it started doing other things. Its started giving me clarity. It gave me mental focus and energy and started giving me my life back.

He now channels that energy into getting more TMS treatments to veterans in the Buckeye State.Working with Senator Hoagland and local sheriffs departments, they want to make sure its available to anyone, anywhere who needs it.

Harkins said hes already began that initial EEG on several veterans and first responders in Noble County to set up the next treatment site.

Its gonna start right here in the Ohio Valley and its going to spread out across the state.

If youre a veteran or first responder and would like to learn more about TMS and what it does, you can call Dirk Harkins at 740-491-7125.

More here:

30 days, life-changing results: The new treatment available to veterans in the Ohio Valley - WTRF

Its zanier, brainier, and insanier. Warner siblings Yakko, Wakko, and Dot have returned for the brand-new Season 2 of Steven Spielbergs rebooted cartoon comedy series, Animaniacs, now airing on Hulu. The wild and wacky animated variety show originally ran for five seasons before wrapping in 1998. Over two decades later, Warner Bros. has brought back the Emmy Award-winning series, with Family Guys Wellesley Wild serving as showrunner and executive producer along with Spielberg and Kung Fu Panda: Legends of Awesomeness Gabe Swarr.

Other executive producers include President of Warner Bros. Animation Sam Register as well as Amblin Television Co-Presidents Darryl Frank and Justin Falvey. The new seasons antics range from historical quips and bits, to riffs on Netflix and outer space excursions. Season 2s 13 episodes also feature previously rejected Animaniacs characters and, according to Swarr, are filled with even more earworm songs that viewers just won't be able to get out of their heads.

The best part about working on this show is being able to go anywhere and do anything, says the EP. We're so thankful and grateful for this opportunity. And Steven has been our guiding light.

But when first approached about rebooting the series, Swarr initially declined.

I actually said no a couple times to doing the show because I was really worried about the fans and if we would do a good job or not, he explains. Animaniacs has had such a loyal following, so I was very apprehensive.

Even though Swarr says he was part of the Ren & Stimpy camp during the shows original run, he was very familiar with the popularity of the series and didnt want to do wrong by the fans. He finally got on board after realizing that rebooting Animaniacs gave him a long-awaited opportunity that he likely wouldnt get again.

I love variety shows, says Swarr. I always wanted to do a variety show like Monty Python or The Muppet Show. But its so hard to do that in animation and I figured this was going to be my only opportunity to ever do it. I tried to pitch a variety show a bunch of times and it was always a really hard sell because there's never a built-in audience. And this is the one time where you could do it with a built-in audience. Plus, I'm kind of smart-assy too, which is the perfect attitude for Animaniacs.

Rebooting a series in 2020 thats known for its unapologetic stabs at pop-culture certainly was a hefty task, and Swarr says it took a lot of research for the team to initially get their footing. We went back and watched nearly every episode from the original series, he shares. There are definitely certain things that aren't as woke anymore, and we didn't want to lean into that at all. But we also wanted to make commentary on everything we could.

From streaming subscriptions to Gladiator film quotes, Animaniacs touches not just on current topics, but older references for older viewers as well. Afterall, just like the original series, the bits arent just for the kids.It is walking that fine line, confirms Swarr. The original show was set up to be for family viewing. It wasnt just for kids, and it wasn't just for adults. In the beginning of the production on the reboot, we were brought in and told, Okay, here's the show, and your target audience is 10 to 25. Thats a wide range and its amazing getting to put jokes in a show that go over kids heads, but then also keep all the slapstick for the younger audience.

He adds, Were always straddling between those two features. But finding that balance not only makes the show better, but its also where the show needs to be.

Though most of the jokes are new - or jokes about doing worse versions of old jokes from the original series - the animation should feel extremely familiar. Swarr says that he and the team took great care in producing animation as close to the original as possible.

We wanted to style the new series off the best of the original, and as the original show went on, the animators got better and better at drawing the characters, Swarr reveals. Certain studios Warner Bros. had worked with in the past really stood out to us. My favorite one was the Japanese studio called TMS, Tokyo Movie Shinsha. I had a chance to interview one of the directors from that studio who worked on the original Animaniacs and got to ask every question I could. After talking with them, it was very obvious the studio had been doing their own thing and their own take on these characters - simplifying their anatomy, changing the proportions a little bit, making them more streamlined. So thats what we did, looking at how TMS interpreted the Warner Bros. models, and went from there.

Leaning into the classic hand-drawn, 2D style, Swarr says their team set up the visuals to be as exactly like the original as we could, avoiding modern tricks like After Effects blurs.

He continues, We're really trying to show off that original look and do it in the most traditional way possible.

But, like any good variety show, tradition hasnt stopped Swarr and the production team from adding in a few visual surprises in the second season.

We go to a lot more places visually in this season than in Season 1, he says, careful not to give too much away for the sake of surprise. This show is almost like a playground where I can just play visually with different mediums of animation and animation styles. We definitely took advantage of that in this season.

Animaniacs was also renewed for a third season shortly after the first season released, and Swarr says its been a blessing as far as way the show is staffed and produced. Season 3 is our first chance to really react to what the audience thought about the first season, because the first and second seasons were all done at the same time he says. Which is why we didn't want to lose our first season writers and artists. That's always what you're always up against with TV. And the DNA of the show really changes if you can't keep the same crew. You'll lose the tone. That's the hardest part. So, aside from wanting the show to continue, that was a big reason we were really excited to be picked up for more seasons so early.

Now, Swarr and the rest of the crew have their fingers crossed that the Animaniacs hijinks continue with a Season 4 pick-up. Wed really love to keep everyone on board and keep going, says Swarr. All the writers are amazing, and everyone just comes up with so many great ideas. And then hopefully, with the fourth season, we will have some ideas from audiences' reactions to Season 2.

Victoria Davis is a full-time, freelance journalist and part-time Otaku with an affinity for all things anime. She's reported on numerous stories from activist news to entertainment. Find more about her work at victoriadavisdepiction.com.

Read the rest here:

Yakko, Wakko, and Dot Return: 'Animaniacs' Season 2 Mayhem Arrives! - Animation World Network

Constrained capacity has been a major issue throughout all of 2021, and is expected to continue even after the holiday season. For shippers and freight brokers, there have been serious rate increases as well as capacity constraints. Currently, there is no end in sight and sourcing capacity will likely prove difficult through at least the first quarter of 2022 as supply and demand struggle to strike a balance during the peak season.

The recent shift to online shopping has caused an e-commerce boom which has only increased the need for drivers in the freight industry. The drastic shift in adoption from paper and spreadsheets to a clickable dashboard continues to grow. Having a way to effectively communicate and also keep yourself organized is why adopting and integrating smarter and real-time technologies such as a TMS software are continuing to grow.

Freight brokers and transportation experts continue to invest in transportation management software that has replaced bulletin boards and handshakes during COVID.

Relationships are the most important thing in a market like this, says Sean McGillicuddy, VP of Sales at Tai Software. The relational aspect of this business is not going anywhere, and brokers need to double down on having good relationships with carriers.

It is important for brokers who have not yet adopted a modern TMS solution to understand that there are so many new features that were previously unavailable within a TMS. These enhancements can now automate the repetitive processes while also allowing a direct touchpoint to every customer. The TMS software also can now directly integrate with other systems through an API which cuts out the middleman.

We are seeing really successful brokers take advantage of technology and adopting some of the digital tools like freight-matching software to make sure their team can move faster at getting a load out to their top carriers and onto load boards, McGillicuddy said. If the technology is doing a lot of work for them in the background, you free your top talent up to make more money.

Brokers should be able to utilize these cutting-edge technologies through their TMS. A high-quality TMS like the one provided by Tai should be built for scalability and offer simple integrations. This makes adding on new technologies less of a headache, cutting down frustration and training time.

Click here to learn more about Tais all-in-one domestic TMS.

Continued here:

Maintaining valuable relationships with a TMS - FreightWaves

This article was originally published here

Adv Ther. 2021 Oct 29. doi: 10.1007/s12325-021-01964-8. Online ahead of print.

ABSTRACT

INTRODUCTION: Alzheimers disease (AD) is usually accompanied by different degrees of behavioral and psychological symptoms of dementia (BPSD). Transcranial magnetic stimulation (TMS) has been applied for the treatment of AD as a painless and noninvasive therapy. However, the efficacy of repetitive TMS (rTMS) with different frequencies in AD with BPSD remains unknown.

METHODS: A total of 32 AD patients with psychobehavioral symptoms were selected as the study subjects. Among them, 16 patients were included in the high-frequency TMS group with an average disease duration of 6.22 2.55 years. The low-frequency TMS group was gender and age matched with a disease course of 7.02 3.33-year average duration. The high-frequency TMS group received TMS treatment twice per day for 4 weeks under 80% MT stimulation intensity, 10-Hz frequency for 0.5 h each time, and the low-frequency TMS group received TMS treatment of 2-Hz frequency for 0.5 h each time. Neuropsychological status was assessed by the Behavioral Pathology in Alzheimers Disease Rating Scale (BEHAVE-AD) score. The behavioral ability was assessed by the Abilities of Daily Living (ADL) scale; cognitive function was evaluated by Mini-Mental State Examination (MMSE). The levels of amyloid 40 and 42 (A40 and A42) in plasma were detected using a double-antibody sandwich enzyme-linked immunosorbent assay. All patients underwent brain magnetic resonance imaging (MRI) before and after the experiment.

RESULTS: After 2 weeks of treatment, the BEHAVE-AD and ADL scores of the patients in the high-frequency group were significantly lower than those before the treatment, and they continued to decrease after 4 weeks of treatment. The BEHAVE-AD and ADL scores of the low-frequency TMS group were also significantly lower than before treatment. The comparison between groups at different time points showed that the BEHAVE-AD and ADL scores of the patients in the high-frequency group were significantly lower than those of the patients in the low-frequency TMS group. The MMSE of high-frequency TMS-treated patients increased from 14.22 3.55 before treatment to 14.67 2.22 at 2 weeks treatment and 17.33 3.11 at 4 weeks treatment (p < 0.01) in contrast to 14.19 3.47, 14.28 3.41, and 14.49 2.79, respectively, found in the low-frequency TMS group. At week 4, the high-frequency TMS-treated groups plasma A40 did not change compared to that before treatment. No effects on plasma A42 were observed between the high- vs. low-frequency TMS groups. The incidence of adverse reactions during treatment was comparable between groups.

CONCLUSION: These results indicate that high-frequency TMS has the advantages of fast results, good efficacy, and high safety for the treatment of psychobehavioral abnormalities in AD patients. In addition, our study suggests that high-frequency TMS intervention can further improve the cognitive function of AD patients.

PMID:34716559 | DOI:10.1007/s12325-021-01964-8

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The Efficacy of High- or Low-Frequency Transcranial Magnetic Stimulation in Alzheimer's Disease Patients with Behavioral and Psychological Symptoms of...

The industry research report Global TMS Neuronavigation Systems Market 2021 consists of an in-depth analysis of the global industry that aims to offer a comprehensive study of market insights associated with the most important components of the market. The report provides an overview of these markets on various fronts, such as market size, market share, market penetration of products and services, downstream areas in the market, large suppliers operating in the territory, analysis prices, etc. This can help readers of the global business industry to better understand the large regional and national markets for TMS Neuronavigation Systems. The reports contain an overview and review of the leading companies operating in the industry that are considered to be revenue-driving for the market.

The market report on TMS Neuronavigation Systems concludes by sharing the reports important results with readers. Here, based on a study of historical data, which examines the scenarios currently seen in different markets, including regional and national, and the trends recorded, provides a forecast for the market. This includes segment forecast, regional market forecast, market size forecast, consumption forecast.

Get FREE Sample copy of this Report with Graphs and Charts at:https://reportsglobe.com/download-sample/?rid=137883

Top Key Players Profiled in this report are:

The report is an assortment of direct information, subjective and quantitative assessment by industry specialists, contributions from industry examiners and TMS Neuronavigation Systems industry members over the worth chain. The report offers a top to bottom investigation of parent market patterns, macroeconomic measures, and control components. Besides, the report likewise overviews the subjective effect of unmistakable market factors on TMS Neuronavigation Systems market sections and geologies.

TMS Neuronavigation Systems Market Segmentation:

Based on Type

Based on Application

Global TMS Neuronavigation Systems Market: Regional Segments

The different section on regional segmentation gives the regional aspects of the worldwide TMS Neuronavigation Systems market. This chapter describes the regulatory structure that is likely to impact the complete market. It highlights the political landscape in the market and predicts its influence on the TMS Neuronavigation Systems market globally.

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The Study Objectives are:

This report includes the estimation of market size for value (million USD) and volume (K Units). Both top-down and bottom-up approaches have been used to estimate and validate the market size of TMS Neuronavigation Systems market, to estimate the size of various other dependent submarkets in the overall market. Key players in the market have been identified through secondary research, and their market shares have been determined through primary and secondary research. All percentage shares, splits, and breakdowns have been determined using secondary sources and verified primary sources.

Some Major Points from Table of Contents:

Chapter 1. Research Methodology & Data Sources

Chapter 2. Executive Summary

Chapter 3. TMS Neuronavigation Systems Market: Industry Analysis

Chapter 4. TMS Neuronavigation Systems Market: Product Insights

Chapter 5. TMS Neuronavigation Systems Market: Application Insights

Chapter 6. TMS Neuronavigation Systems Market: Regional Insights

Chapter 7. TMS Neuronavigation Systems Market: Competitive Landscape

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TMS Neuronavigation Systems Market 2021 Detailed Analysis of top Ventures with Regional Outlook | Key Companies: Neurosoft (Russia), Soterix Medical...

Latest Features Ensure Trucking Operations Are Running Profitably

DALLAS, Oct. 26, 2021 (GLOBE NEWSWIRE) -- Axele, LLC, a Transportation Management System (TMS) company, announces new updates to its award-winning TMS that expands ELD integrations, reporting, and dispatch operations. New reporting capabilities allow companies to track total load expenses and net income to ensure trucking operations are running profitably. Other features expand digital processes to automate operations and reduce paperwork.

These new features will speed processing of documentation to improve record-keeping and driver reconciliation, ensuring profitability for small and midsized trucking businesses, said Ravi Ahuja, Founder of Axele. We add these enhancements based on feedback from users; then add them as soon as possible, so customers grow their businesses quickly with our system. Axele is continuously learning and improving more connections, more automation, more optimization all with the intent to make our users more productive and more profitable.

The list of expanded features for this latest upgrade includes:

Users can now import past loads, making it easy to reconcile loads built with a prior TMS solution or another third-party system within the Axele TMS.

Rate confirmation data extraction now supports JT Wash and Forward Air, meaning the TMS will auto-fill rates and populate new loads from these logistics providers. JT Wash specializes in produce transportation, while Forward Air is a leading provider of ground transportation and related logistics services to the North American air freight and expedited LTL market.

Fuel card import now supports the Pilot Flying J Axle Fuel Card and EFS Fuel Cards from WEX, helping reduce the time needed for accounting processes. Carriers using Axele can connect directly to their Pilot Flying J and EFS accounts without leaving the TMS.

New ELD integration support for 3MD and VisTracks. 3MD is an ELD that is multi-lingual and great for truck drivers and owner-operators. VisTracks is a white-labeled SaaS-based ELD platform recently acquired by Omnitracs/Solera.

Toll transactions can now be imported from:

E-Zpass

Bestpass

I-Pass

PrePass

The ability to directly import toll transactions means drivers will not have to handle paper tickets or input information from paper receipts, speeding reimbursement.

New reports available: Axele expands its reporting capabilities to track gross revenue, total load expenses, net income, and loaded/empty miles by the customer, tractor, or trailer. These reports can monitor whether a business is hitting its KPIs and growing its business.

New Driver Dispatch Sheet: Axele provides a PDF document that shares load details, minus revenue, with your driver within each load to serve as a quick driver reference sheet. Revenue is omitted for scenarios where the driver should not be privy to the contracted rate.

New Driver Dispatch Rate Confirmation: Located within each load, the TMS provides a PDF document that shares load details with your dispatcher, including revenue. In contrast to the Driver Dispatch Sheet, the Rate Confirmation includes revenue details for scenarios where the driver should be aware of the contracted rate.

The Axele TMS is available free or for a small fee for advanced features, including smart trip planning, operational dashboards, market intelligence, end-to-end planning, and more. Users harness the power of Axeles optimization and automation technology with the touch of a button. Axele is a one-stop-shop for customers, automating day-to-day operations and optimizing load planning to increase profits.

Story continues

About AxeleAxele offers transportation management system (TMS) cloud software for truckload carriers leveraging decades of experience and insights into optimization and automation technology. Launched by Optym in 2020, Axele is the industry's first intelligent, connected solution, built specifically for small to mid-sized truckload carriers. Axele serves for-hire truckload operators and private fleets who haul general freight, dry van, flatbed, and refrigerated loads. The Axele TMS integrates with load boards, ELDs, market rates, maps, and accounting systems, to enable an owner-operator or carrier to find better loads, increase profits, and grow their business. For more information about Axele, go to http://www.axele.com.

Media Contact for Axele:Becky BoydMediaFirst PR(770) 642-2080 x 214Cell (404) 421-8497Becky@MediaFirst.Net

Visit link:

Axele Updates TMS with Expanded ELD Integrations, Reports to Track Total Load Expenses, and Digital Dispatch Documentation - Yahoo Finance

The report examines all the key factors affecting the expansion of the world Treasury Management System (TMS)s market, including demand supply scenarios, price structure, gross margin, production and value chain analysis. The regional assessment of the world Treasury Management System (TMS) market release numerous untapped opportunities within the regional and domestic markets. Detailed company profiling allows users to judge company stock analysis, new product lines, NPD coverage in new markets, pricing strategies, innovation potential, and more.

Get | Download Sample Copy with TOC, Graphs & List of [emailprotected]https://www.marketresearchintellect.com/download-sample/?rid=181900

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Overview of the impact of Covid-19 on the Treasury Management System (TMS) Market:

The emergence of COVID-19 brought the world to a standstill. We understand that this health crisis has had an unprecedented impact on business across the industry. But this will also pass. Increased support from governments and companies can help fight this highly contagious disease. There are industries that are struggling and there are industries that are thriving. Overall, almost all sectors are expected to be affected by pandemics. We are committed to ensuring that your business lasts and grows during the Covid-19 epidemic. Our experience and expertise will help us prepare for the future by providing impact analysis of coronavirus outbreaks across the industry.

Treasury Management System (TMS) Market breakdown by Type:

Regional market analysis Treasury Management System (TMS) can be represented as follows:

Each regional Treasury Management System (TMS) sectors is carefully studied to understand its current and future growth scenarios. This helps players to strengthen their position. Use market research to get a better perspective and understanding of the market and target audience and ensure you stay ahead of the competition.

Visualize Treasury Management System (TMS) Market using VMI @ hhttps://www.marketresearchintellect.com/mri-intelligence/

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Market Research Intellect provides syndicated and customized research reports to clients from various industries and organizations in addition to the objective of delivering customized and in-depth research studies.We speak to looking logical research solutions, custom consulting, and in-severity data analysis lid a range of industries including Energy, Technology, Manufacturing and Construction, Chemicals and Materials, Food and Beverages. Etc Our research studies assist our clients to make higher data-driven decisions, admit push forecasts, capitalize coarsely with opportunities and optimize efficiency by bustling as their belt in crime to adopt accurate and indispensable mention without compromise.Having serviced on the pinnacle of 5000+ clients, we have provided expertly-behaved assert research facilities to more than 100 Global Fortune 500 companies such as Amazon, Dell, IBM, Shell, Exxon Mobil, General Electric, Siemens, Microsoft, Sony, and Hitachi.

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Originally posted here:

Treasury Management System (TMS) Market Growth, Sales, Future Trends, COVID-19 Impact, Size Value and Analysis By 2028 | Oracle, Finastra, Salmon...

Press release, Helsinki, 27 October 2021 at 9 AM (EEST)

Nexstim Receives an NBS System Order from a Hospital in the Middle East

Nexstim Plc (NXTMH:HEX, NXTMS:STO) ("Nexstim" or "Company") announces having received an NBS system order from a hospital in the Middle East.

Nexstims NBS system is the only FDA cleared and CE marked navigated TMS system for pre-surgical mapping of the speech and motor cortices of the brain. This specific NBS system also includes the software of an NBT system, allowing the system to also be used for therapeutic treatments.

Mikko Karvinen, CEO of Nexstim commented: Even though our presence is the strongest in the North American and European markets, operating in markets such as the Middle East is important for us. We are happy to see internationally occurring interest in our systems that enable both diagnostic and therapeutic applications. At Nexstim, we work hard to bring our technology available for as many people as possible; offering solutions to the global challenge of how to effectively diagnose and treat brain diseases and disorders.

Further information is available on the website http://www.nexstim.com, or by contacting:

Mikko Karvinen, CEO+358 50 326 4101mikko.karvinen@nexstim.com

About Nexstim Plc

Nexstim is a Finnish, globally operating medical technology company. Our mission is to enable personalized and effective therapies and diagnostics for challenging brain diseases and disorders.

Nexstim has developed a world-leading non-invasive brain stimulation technology called SmartFocus. It is a navigated transcranial magnetic stimulation (nTMS) technology with highly sophisticated 3D navigation providing accurate and personalized targeting of the TMS to the specific area of the brain.

SmartFocus technology is used in Nexstims proprietary Navigated Brain Therapy (NBT) system, which is FDA cleared for marketing and commercial distribution for the treatment of major depressive disorder (MDD) in the United States. In Europe, the NBT system is CE marked for the treatment of major depression and chronic neuropathic pain.

In addition, Nexstim is commercializing its SmartFocus based Navigated Brain Stimulation (NBS) system for diagnostic applications. The NBS system is the only FDA cleared and CE marked navigated TMS system for pre-surgical mapping of the speech and motor cortices of the brain. Nexstim shares are listed on the Nasdaq First North Growth Market Finland and Nasdaq First North Growth Market Sweden.

For more information please visit http://www.nexstim.com

View original post here:

Nexstim Receives an NBS System Order from a Hospital in the - GlobeNewswire