Category Archives: Food Supplements

Selenium Yeast Market to Exceed US$ 375.9 Mn by 2032 as Adoption of Organic Selenium Yeast as a Health Supplement Grows | Future Market Insights, Inc….

Posted: August 15, 2022 at 6:44 pm

NEWARK, Del, Aug. 11, 2022 (GLOBE NEWSWIRE) -- The global selenium yeast market is set to witness growth at a CAGR of 3.7% and top a valuation of US$ 375.9 Mn by 2032, as per Future Market Insights (FMI). Selenium as an important trace element is required to maintain good health and a balanced nutrient profile.

Selenium yeast is an essential compound product containing selenoproteins which is required by several other important anti-oxidants to convert hormones from inactive to active form. As an optimal selenium level is very important in order to maintain a healthy and proper body function, intake of selenium-based diet and supplements should be accurate, which can be provided by selenium yeast perfectly.

Selenium yeast in any form is utilized by selenoprotein synthesis of the body and it works best when organically sourced. This is easily metabolized as a cellular storage form of selenium, known as hydrogen selenide.

Selenomethionine absorption works best, as organic selenium yeast uses same active transport mechanism like methionine, which is an essential amino acid. This can only be dietary selenium which is more efficient than inorganic forms of selenium in terms of selenomethionine absorption. Some selenium yeast supplements include vitamin E as well to further facilitate selenium absorption and increase its antioxidant effects.

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Key Takeaways from Market Study

Organic selenium yeast supplements are essential due to several facilities it provides to human health including higher anti-oxidant activities and other nutrients absorption, which is driving the growth in food, pharmaceuticals, and animal feed industries over the forecast period, says a Future Market Insights analyst.

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Competitive Landscape

Key selenium yeast brands are focusing on sustainable and organic product developments, while extending the product portfolio with extensive research procedures and several modifications to capture more market share in global arena and to further boost the industry growth.

Explore More Valuable Insights

Future Market Insights, in its new report, offers an impartial analysis of the global selenium yeast market, presenting historical data (2017-2021) and estimation statistics for the forecast period of 2022-2032.

The study offers compelling insights based on nature (organic and conventional), grade (food grade and feed grade), and application (food & beverages, nutraceuticals & dietary supplements, animal feed, and others), across seven major regions of the world.

About Food & Beverage Division at Future Market Insights

The Food & Beverage team at Future Market Insights provides all the necessary insights and consulting analysis to fulfill the unique business intelligence needs of clients worldwide. With a catalog of more than 500 reports pertaining to the latest statistics and analysis from the food & beverage industry, the team is happy to help with every business intelligence research and consulting requirement.

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Table of Content

1. Executive Summary

1.1. Global Market Outlook

1.2. Demand-side Trends

1.3. Supply-side Trends

1.4. Technology Roadmap Analysis

1.5. Analysis and Recommendations

2. Market Overview

2.1. Market Coverage / Taxonomy

2.2. Market Definition / Scope / Limitations

3. Market Background

3.1. Market Dynamics

3.1.1. Drivers

3.1.2. Restraints

3.1.3. Opportunity

3.1.4. Trends

3.2. Scenario Forecast

3.2.1. Demand in Optimistic Scenario

3.2.2. Demand in Likely Scenario

3.2.3. Demand in Conservative Scenario

3.3. Product launches & Recent Developments

3.4. Macro-Economic Factors

3.5. Value Chain Analysis

Animal Feed Additives Market is Estimated to Progress at a CAGR of 5.2% during the Forecast Period, notes TMR Study – GlobeNewswire

Posted: at 6:44 pm

Wilmington, Delaware, United States, Aug. 09, 2022 (GLOBE NEWSWIRE) -- Transparency Market Research Inc. - The revenue of animal feed additives market is likely to surpass US$ 66.23 Bn by 2031. The global market is expected to rise at a CAGR of 5.2% during the forecast period, from 2021 to 2031. Amino acids are crucial for many biological functions, such asmetabolism,food consumption, digestion, and also reproduction Methionine, one of the several forms of amino acids, is mostly employed in the poultry business, whereas lysine is utilized in the pork business. Extensive use of amino acids is likely to emerge as largest opportunity for animal feed additives market in the near future.

Large producers of animal feed additives are vying for certifications from reputable organizations that are in charge of protecting the welfare of animals and upholding high standards for food quality. The standards andquality of company's products could be raised, and their acceptance rate in various local markets could rise, by acquiring these certifications. This factor is a recent developments in the animal feed additives market.

Producers of animal feed additives from a variety of sources are increasingly shunning globalization trends in favour of a localized strategy that entails procuring raw ingredients from certain regions and countries. Many producers of feed additives are also building local distribution networks, which aids in insulating their companies from external influences and risky trade regulations.

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Key Findings of Market Report

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Global Animal Feed Additives Market: Growth Drivers

Global Animal Feed Additives Market: Key Players

Some of the key market players are

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Global Animal Feed Additives Market: Segmentation

Type

Source

Form

Livestock

By Regions

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About Transparency Market Research

Transparency Market Research, a global market research company registered at Wilmington, Delaware, United States, provides custom research and consulting services. The firm scrutinizes factors shaping the dynamics of demand in various markets. The insights and perspectives on the markets evaluate opportunities in various segments. The opportunities in the segments based on source, application, demographics, sales channel, and end-use are analysed, which will determine growth in the markets over the next decade.

Our exclusive blend of quantitative forecasting and trends analysis provides forward-looking insights for thousands of decision-makers, made possible by experienced teams of Analysts, Researchers, and Consultants. The proprietary data sources and various tools & techniques we use always reflect the latest trends and information. With a broad research and analysis capability, Transparency Market Research employs rigorous primary and secondary research techniques in all of its business reports.

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Animal Feed Additives Market is Estimated to Progress at a CAGR of 5.2% during the Forecast Period, notes TMR Study - GlobeNewswire

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A Systematic Review of Nutritional Interventions on Key Cytokine Pathways in Rheumatoid Arthritis and Its Implications for Comorbid Depression: Is a…

Posted: at 6:44 pm

The inflammatory profile of rheumatoid arthritis (RA)

RA is a chronic disease characterized by the autoimmune destruction of joints and synovial tissues, which results in pain, deformity, and reduced quality of life in patients with RA[1].Because of the chronic painpatients with RA endure, the mainstay of treatment aims to reduce inflammation to both suppress symptoms and prevent further joint damage whenever possible [1]. RA is associated with both local and systemic inflammatory processes via the aberrant regulation of inflammatory pathways and imbalances in several mediators of inflammation which are looked at in detail in this study [2]. These systemic inflammatory processes link RA with other inflammatory comorbidities such as cardiovascular disease, malignancy, lung disease, osteoporosis, and neuropsychiatric diseases including depression [3-4]. Due to the expense and side effect profiles of drug regimens for pharmaceutical disease management, [1], and the increasing number of publications addressing the role of nutrition in RA treatment [1,5-6], and the correlation of RA with depression, [3,7-10], the primary objective of this review was to identify and summarize which specific dietary patterns and nutritional interventions go beyond symptom management to improve the response to known inflammatory cytokines and other inflammatory markers in the RA disease process.

Cytokines are chemical messengers in the body that are secreted by the immune system and can influence communication between cells [11]. Cytokines including tumor necrosis factor-alpha (TNF-), interleukin (IL)-1B, IL-6, IL-17, and IL-18, as well as inflammatory markers like C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) that have been used in diagnosing and tracking the progression of RA [11-12]. In many immune reactions and disease processes, TNF-, IL-6, and IL-1B increase inflammation and leukocyte recruitment, while counter-regulatory cytokines IL-4 and IL-10 decrease inflammation [11]. Dysregulation and imbalance of these systems is the mechanism behind the autoimmune dysfunction seen in RA [11]. Activated macrophages in the joint tissues of RA patients secrete various pro-inflammatory cytokines [11,13]. TNF- activates fibroblasts and IL-1B causes fibroblast proliferation [13]. This chain of reactions subsequently activates transcription factor nuclear factor-kB (NF-kB), which is one of the main inflammatory pathways seen in RA [13]. In this pathway, the receptor activator of nuclear factor kappa-B ligand (RANKL), which via increased osteoclast activity is involved in bone regeneration and remodeling, is both triggered by and produces high levels of IL-1, TNF-, and IL-6 [13]. Increased NK-kB expression also results in increased levels of metalloproteinases (MMPs), specifically MMP-2 and MMP-9, which are the enzymes responsible for breaking down cartilage in the synovial fluid of RA patients [11]. Additionally, IL-18 is found in relatively higher concentrations in the synovial tissues of RA patients, which, also via activation of NF-B, induces interferon-gamma (IFN-) production from T-cells and natural killer cells in synovial tissues [14]. Finally, studies have shown that IL-17 expression and serum concentrations of IL-6 correlate with RA clinical disease activity [15-16]. IL-17, in addition to provoking the production of pro-inflammatory cytokines IL-6 among others; also encourages Th17 immune cell differentiation, a pro-inflammatory immune pathway, which in patients with RA increases RANKL expression and subsequent osteoclastic activity [17]. In summary, the cytokine processes responsible for disease progression and inflammation in RA involve complex feedback mechanisms principally among interleukins IL-1B, IL-6, IL-17, IL-18, and TNF-, which is why this review has sought out dietary patterns and nutritional interventions that have attempted to measure impact upon these pathways.

The impact of various dietary patterns and nutritional interventions on the disease activity in RA has been investigated by several recent systematic reviews [1,5-6]. The findings from these previous publications support the link between various dietary components, inflammatory markers, and disease activity in RA [1,5-6]. For example, elimination diets, which focus on the removal of common inflammatory foods such as dairy, wheat, and refined sugars, have been shown to lower serum CRP, ESR, IL-1B, and TNF- a, while subsequent food challenges showed increasein these inflammatory markersand subsequent worsening of RA symptoms [1,5]. Other studies have shown that supplementation with high doses of polyunsaturated fatty acids (PUFAs) reduces ESR, CRP, and IL-1B levels while improving Disease Activity Score-28 (DAS-28) scores and quality of life measures in patients with RA [5,6]. Other established findings further supporting the role of dietary intervention in the management of disease in patients with RA include evidence for lowered disease activity with interventions including the Mediterranean diet, flavonoid-containing spices (ginger powder, cinnamon powder, saffron), antioxidants (quercetin and ubiquinone), and probiotics [1,6]. While previous reviews have established the important role diet plays in the management of RA, they have not focused on specific cytokine pathways, nor have they addressed inflammatory comorbid conditions like depression.

While depression is commonly found in patients who suffer from chronic illnesses, it is especially prevalent in the RA population, up to 42% [8,10]. Compared to healthy matched controls, patients with RA are more than twice as likely to develop depression[3,9]. This has important consequences for patient quality of life, as studies have shown that patients with RA and comorbid depression are more likely to be unemployed (30% versus patients with RA without depression symptoms) and that patients with RA and depression generally display higher DAS and levels of functional disability, with disability correlating to the severity of depression [8,18]. Additionally, Timonen et al. (2003) found reports of suicidal ideations in 14% of female patients with RA and 3% of male patients with RA in a prospective 13-year cohort study [19]. In patients with RA, 52.6% of suicides are by females versus 18.2% in victims who had neither RA nor osteoarthritis (OA), and the median age of completion was 61.7 years old versus 41.3 years old in victims with neither RA nor OA [19]. The pathology of depression is associated with systemic inflammation, which is a known outcome of RA and may explain this strong association [10]. Cytokines IL-6, IL-1, and TNF-, known mediators involved in the progression of RA, are strongly associated with stress-related disorders including depression and anxiety [7,10]. The presence of these cytokines is also correlated with the severity and duration of depression, marking a possible signal to the potential use of cytokines in diagnosing and following the progression of depression not only in patients with RA but also in others [10]. This is where the present review of literature postulates the potential for nutrition and dietary-based interventions playing a role in improving cytokine profiles in patients with RA not only in the hopes of improving traditional disease progression markers focused solely on the musculoskeletal system but also of improving other cytokine-mediated comorbidities, especially depression.

While various dietary patterns and nutritional interventions, as well as supplement studies, have been carried out to propose alternative treatments that might augment traditional pharmaceutical therapy for individuals with RA [5-6,20], given the importance of inflammatory cytokines on the disease progression in RA, on disabling comorbidities like depression, and on their use as biomarkers for disease activity, a new look at nutrition and diet studies was warranted with cytokines and other inflammatory markers specifically in mind. Focusing on a broader cytokine profile than those included in the commonly used DAS-28 for RA (CRP and ESR) allows for a better understanding of how nutritional interventions or dietary patterns directly influence the chronic inflammatory processes of RA. It also allows for more questions to be asked regarding the effect of such interventions on comorbid inflammatory conditions in patients with RA, which share many of the same inflammatory pathways and markers. In summary, identifying nutritional interventions and dietary patterns that improve the inflammatory cytokine profile, and therefore disease progression and inflammatory comorbidities of RA will help further focus research on treatments that may provide a better overall improvement in quality of life for RA patients by focusing on root cause inflammatory processes that affect not only joint description but also depression-rated disability.

Search Strategy

A computer-assisted systematic literature review was performed using PubMed for primary source research articles examining nutritional interventions in the cytokine profiles of patients with RA. The PubMed word search included rheumatoid arthritis and nutrition or diet and c-reactive protein or IL-1 or IL-6 or IL-17 or IL-18 or cytokines. Articles were filtered to include those published between 2016 and 2022 to improve efficacy of the review and capture the most recent and prominent research. The reference list of retrieved articles was also considered when found to be relevant and if those additional articles fit the search criteria but were not discovered through the initial search. The relevance of these articles was assessed through a hierarchical approach, with evaluation first of the title, then the abstract, followed by the full manuscript. For any articles not freely available, access was gained through the Nova Southeastern University library.

Selection Criteria

Studies were considered eligible if they examined specific nutritional interventions in the disease modification of RA and measured the interventions effect on one or multiple serum cytokines. Eligible study designs included randomized control trials (RCT), prospective and retrospective cohort studies, cross-sectional studies, case studies, and other studies on human patients and/or human cell lines. Exclusion criteria included meta-analyses, systematic reviews, editorials, non-human studies, and lack of access to the available text. A flow diagram was developed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 outline [21] (Figure 1).

A total of 236 articles were identified from the initial electronic database search. Seventy-sixarticles were excluded based on lack of relevance found during the title and abstract screening, and 18 duplicates were removed. Of the remaining 124 articles, 83 were excluded for no nutritional intervention mentioned, minimal focus on RA, ineligible study design (based on exclusion criteria), or lack of access to the full text. A total of 41 articles remained for inclusion in this review (Table 1). Most of the publications identified (35 of 41) analyzed dietary patterns or dietary supplements, and the remaining sixlooked at herbal or other supplements. None of the articles measured any improvements or worsening of symptoms of depression as a result of the studied intervention(s).

From the analyzed publications, four main overarching themes stand out: 1. Poor diet quality and/or poor adherence to anti-inflammatory diets in patients with RA results in increased inflammatory markers and pain scores [22-31]; 2. Dietary consumption of antioxidants, PUFAs, and fiber have preferable disease outcomes in patients with RA, whereas salt does not [32-38]; 3. Flavanoid supplementation, particularly with barbary extract, cinnamon, cranberry juice, curcumin, garlic, saffron, pomegranate extract, sesamin, and diindolylmethane (DIM) in patients with RA has shown promising results in reducing inflammatory cytokines active in the RA disease process [39-51]; and 4. Probiotic supplementation may be beneficial in ameliorating the profile of gut microbiota in patients with RA, also resulting in decreased disease activity [52-56].

Dietary Patterns

A significant number of the publications (26 of 41) identified focused on dietary evaluations or interventions. The studies looked at various factors like anthropometrics and diet quality, in addition to identifying various interventions analyzing the effect of fasting diets, other specific diets, and intake of salt, fiber, antioxidants, and PUFAson the inflammatory status of patients with RA. Generally, poor diet quality and diets considered inflammatory has been shown to worsen cytokine profiles and DAS [22,24-28]. Several studies in this review [24-28], found that diets defined as poor in quality (diets with low intake of fish, shellfish, whole grains, fruits, and vegetables and high intake of smoked meats and sweets), diets with higher dietary inflammatory index (DII) scores, diets with low adherence to the Anti-inflammatory Diet in Rheumatoid Arthritis (ADIRA) protocol, or diets with low adherence to the Mediterranean diet are associated with poorer outcomes including higher CRP and ESR levels and increased pain levels. Elimination diets excluding foods known to trigger inflammatory processes, for example, red meat, gluten, and dairy have also been explored as adjuvant treatment for RA patients, with one study showing a significant reduction in CRP levels, in addition to improved pain scores, lower levels of circulating leukocytes and neutrophils, and improved quality of life in patients with RA compared to controls [22].

In addition to dietary content, several other studies identified additional considerations in dietary patterns like timing and underlying anthropometrics. Intermittent fasting in the setting of diurnal fasting during Ramadan was explored as a potential method for remediating inflammation in RA in two studies [29-30]; both found improvements in inflammatory markers and pain scores during the month of fasting. One study that investigated the relationship between anthropometric measurements concluded that weight, BMI, and waist circumference were positively correlated with disease activity in RA [31]. Serum concentrations of CRP and ESR increased with increasing BMI, suggesting dietary interventions aimed solely at weight loss may positively impact disease activity and overall patient quality of life [31]. In regard to the aforementioned adipokines, ADMA, but not nesfatin-1, was associated with higher BMI and disease activity in RA patients [31].

Dietary Consumption of Salt, Antioxidants, and PUFAs

Specific dietary consumption studies included publications evaluating the effect of salt, antioxidants, fiber, and PUFAs consumption [23,32-38]. Recently, the relationship between sodium chloride (NaCl) intake and inflammation has been investigated as a potential modifier of autoimmune diseases such as RA and systemic lupus erythematosus (SLE) [33]. Studies in this review have found that synovial fluid NaCl concentration was associated with enhanced Th17 cell proliferation and resultant increases in disease activity [33] and that patients on a low sodium diet resulted in reduced Th17 cell concentrations and reductions in IL-9 and tumor growth factor beta (TGF-) after just three weeks [34].

Antioxidants play an important role in the balance between pro- and anti-inflammatory processes within the human body and are the subject of one publication in this review. Dietary recalls revealed that patients with RA generally had higher intakes of selenium and copper, and lower intakes of zinc, vitamin E, and magnesium than recommended guidelines [23]. Adequate vitamin C intake was associated with decreased IL-1, zinc intake was associated with decreased IL-2, and magnesium intake was associated with decreased levels of both IL-1 and IL-2, whereas deficient intake of vitamin E and copper were noted to decrease catalase expression, an enzyme largely involved with anti-inflammatory pathways [23].

Five of the articles in this sample discuss the role of PUFAs in reducing inflammation in patients with RA. PUFAs, primarily omega-3 long-chain fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are precursor molecules in the biosynthesis of anti-inflammatory prostaglandins and leukotrienes and act as inhibitors in the conversion of arachidonic acid to inflammatory prostaglandins and leukotrienes [63]. Omega-6 fatty acid alpha-linolenic acid (ALA) also exhibits similar anti-inflammatory activity [63]. Omega-3 supplementation has also been shown to reduce the synthesis of IL-1 and TNF- in monocytes and IL-6 in endothelial cells [64]. Additionally, higher omega-6:omega-3 ratios have been correlated with overproduction of proinflammatory cytokines [64]. Three of the five studies evaluated PUFA consumption via dietary recall [33,37-38]. The first study found that subjects who consumed fish, a food high in PUFA content, two or more times a week to have significantly lower combined DAS-28-CRP scores when compared to RA patients who ate fish never or <1 time/month, and that for each additional serving of fish per week, DAS-28-CRP was significantly reduced [38]. The second study found that diets low in omega-3 PUFAs and diets with greater omega-6:omega-3 ratios were directly associated with unacceptable and refractory pain, but not with inflammatory pain or systemic inflammation, suggesting that omega-3 PUFAs might help with pain control in RA [37]. The last PUFA dietary recall study demonstrated an inverse relationship with erythrocyte levels of the n-6 PUFA linoleic acid, specifically with risk of RA development [35].

Supplementation with PUFAs, Fiber, Flavanoids, and Probiotics

A study [43] concerning supplementation with PUFAs showed statistically significant reductions in DAS-28 scores and adiponectin levels compared to controls in the fish oil only group, and interestingly, better results when consuming fish oil supplements together with cranberry juice, resulting in further reductions in ESR, CRP, and IL-6 levels versus fish oil alone.Another PUFA supplement study with flaxseed showed improved DAS-28 scores but no changes in inflammatory markers[36].

Another dietary component under investigation for RA symptom relief is dietary fiber. Supplementation with high fiber bars developed to contain 30 grams of a combination of non-digestible soluble and insoluble carbohydrates of three or more monomeric units given daily over a 30-day period showed increased systemic short-chain fatty acid (SCFA) levels in RA patients, which are known to decrease inflammation by upregulating Treg cells, decreasing T cell proliferation, and decreasing IL-18 concentrations [32].

Flavonoids are a type of polyphenolic secondary metabolites found in plants [33]. They are widely known to exhibit powerful antioxidant, anti-inflammatory, and immunomodulatory properties [65]. Thirteen of the 41 articles analyzed involved supplement and food interventions known to be high in flavanoid concentrations. RCTsevaluating barbary extract, cinnamon, cranberry juice, garlic, saffron, pomegranate extract, sesamin, polyphenolic extract from olive oil, and DIMextract from cruciferous vegetables showed reductions in several inflammatory cytokines (see Table 1 for cytokines measured with p values) [39-51]. There were mixed results with curcumin with one RCT finding no significant improvements, while another did see decreased CRP, ERP, and other inflammatory markers in patients with RA [44-45]. Finally, no effect was seen in the RCT evaluating Brazilian propolis [40].

Five of the 41 articles analyzed involved interventions with probiotics. Patients with RA were observed to have different gut microbiomes from healthy controls [54-55]. These differences in intestinal bacteria have been shown to contribute to impaired insulin metabolism, further perpetuating inflammation and oxidative stress in patients with RA [55]. Additionally, the gut microbiota is closely linked to systemic inflammatory processes due to its manipulation of macrophage activity [66]. Regarding RA pathogenesis specifically, it is hypothesized that luminal bacterial translocation secondary to increased epithelial permeability and exposure to variable categories and amounts of bacterial antigens are potential links between gut dysbiosis and joint inflammation [28]. Two RCTs found that daily treatment with probiotics in patients with RA resulted in decreased serum hs-CRP levels and improved DAS-28 scores [55-56]. Another RCT evaluating a mixed probiotic showed improvements in inflammatory profiles with reductions in white blood cell count, TNF-, and IL-6 plasma levels, but no difference with placebo in IL-10 levels, adiponectin, CRP, ESR, ferritin, or DAS-28 [52]. Two in vitro interventions with probiotic supplementation showed inhibited levels of IL-6, IL-8, and TNF- [53] and inhibited Th17 cells and IL-17 related genes as well as several other proinflammatory mediators [54].

Of note, the Mediterranean diet, known for its balanced nutrient profile and various antioxidant and anti-inflammatory properties, has been commonly investigated regarding its impact on patients with RA [28]. In addition to demonstrating improvements in inflammatory markers and pain scores, one study in this review sought to evaluate the effect of the Mediterranean diet on the gut microbiota [28]. Their study reported significant decreases in Lactobacillaceae and Prevotella copri species in patients who were highly adherent to the Mediterranean diet, which indicated a healthier gut microbiota compositioncompared to the studys moderate/low adherence counterparts [28].

Other Interventions

Three of the 41 articles identified in this review were RCTs that evaluated the anti-inflammatory benefits of herbal supplements in patients with RA [57-59]. Supplementation with Nigella sativa extract, commonly used in Middle and far Eastern countries as botanical medicine, consumption of stachysschtschegleevii (SSC), a common herbal medicine consumed in the form of tea, and supplementation with Chinese herbal medicine Xinfeng all showed improvements inflammatory markers and DAS [57-59].

The final three studies evaluated do not fit into any of the prior intervention categories. They include human studies on Vitamin K1, n-acetyl cysteine (NAC), and silicon intake [60-62]. Vitamin K1 supplementation, compared to placebo, demonstrated no significant reduction in DAS-28 scores or serum IL-6 levels after adjusting for relevant confounders [62]. Supplementation with NAC, an important facilitator of phase 1 and phase 2 detoxification in the liver that has been shown to improve inflammation profiles, resulted in significantly lower levels of malondialdehyde, NO, and total thiol groups, but no statistically significant difference in serum IL-6, TNF-, ESR or CRP levels between the control and intervention groups [60]. Finally, silicon, which is a common food additive and also ingested from dietary sources like cereals and certain vegetables, is retained by connective tissues and has been correlated with higher collagen concentrations in the skin and cartilage, improved bone density, and some anti-inflammatory responses; however, hypercalcemia causes oxidative stress, and non-dietary sources of silicon (implants) have been found to increase the risk for autoimmune diseases in humans [61]. The study on silicon found that patients with RA, compared to healthy controls, had significantly higher serum concentrations of silicon, and exhibited a negative correlation between silicon levels and the number of swollen joints and serum IL-6 levels, however, these results were only found in females [66]. The study is overall inconclusive, noting that albumin levels, smoking status, and gender interfered with the results [61].

Final Considerations

None of the articles identified in this review measured any improvements or worsening of symptoms of depression as a result of the studied intervention(s). We propose that further studies on RA interventions should track outcomes in inflammatory and cytokine markers, and utilize validated scales and/or accepted measures of disease activity to evaluate any changes in comorbid inflammatory conditions, especially depression, to best provide comprehensive quality of life improvements for patients with RA.

Continued here:

A Systematic Review of Nutritional Interventions on Key Cytokine Pathways in Rheumatoid Arthritis and Its Implications for Comorbid Depression: Is a...

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The Worldwide Food Fortifying Agents Industry is Expected to Reach $128 Billion by 2027 – PR Newswire

Posted: at 6:44 pm

DUBLIN, Aug. 15, 2022 /PRNewswire/ -- The "Food Fortifying Agents Market by Type (Minerals, Vitamins, Carbohydrates, Prebiotics, Probiotics), Application (Cereal & Cereal-based Products, Bulk Food Items), Process (Drum Drying, Dusting) and Region - Global Forecast to 2027" report has been added to ResearchAndMarkets.com's offering.

The food fortifying agents market is projected to reach USD 128.0 Billion by 2027 growing at a CAGR of 10.1% from 2022 to 2027. Increasing consumer awareness with respect to the health benefits associated with fortifying agents and growing preventive healthcare measures undertaken by the consumers is proliferating the demand for food fortifying agents market.

The vitamins segment dominates the market with 26.0% of total market share in terms of value

Vitamins, also known as vital amines, are essential in micro quantities to ensure normal metabolism and growth of the body. They are classified as micronutrients because they are normally required in small amounts; usually a few milligrams (mg) or micrograms (?g) per day. A total of 13 vitamins have been identified, namely, vitamin A & provitamin A, vitamin B (B1, B2, B3, B5, B6, B9, and B12), vitamin C, vitamin D, vitamin E, and vitamin K.

Most vitamins cannot be synthesized by the body, as a result of which, they must be obtained through external sources. An exception is vitamin D, which can be synthesized by the action of sunlight on the skin. The segment held the largest share owing to rising risks of chronic diseases and consumer awareness regarding benefits of vitamins.

Food fortifying agents have high demand in bulk food items industry

The dominance of this application can be attributed due to the increasing demand for high-quality food products and changing health trends, which in turn increases the demand for food fortifying agents. The market is driven by the growing health awareness among consumers, urging companies to offer various food fortifying agents for various applications, such as functional foods, beverages, dietary supplements, infant formula, and dairy, due to their health benefits.

Fortification of bulk food items is an appropriate vehicle for the micronutrient and is widely consumed by the general population; it is intended for intervention programs to address the deficiency in a specific target population.

Asia Pacific is projected to witness the growth of 10.8% during the forecast period

The food fortifying agents market in Asia Pacific is growing at a CAGR of 10.8% due to the increasing health-consciousness among the consumers and the multi-benefits of food fortifying agents. The Asia Pacific food fortifying agent market is competitive in nature having a large number of domestic and multinational players competing for market share.

Emphasis is given on the merger, expansion, acquisition, and partnership of the companies along with new product development as strategic approaches adopted by the leading companies to boost their brand presence among consumers.

Key Topics Covered:

1 Introduction

2 Research Methodology

3 Executive Summary

4 Premium Insights4.1 Brief Overview of the Food Fortifying Agents Market4.2 North America: Food Fortifying Agents Market, by Application and Country4.3 Food Fortifying Agents Market, by Type4.4 Food Fortifying Agents Market, by Application4.5 Food Fortifying Agents Market, by Application and Region

5 Market Overview5.1 Introduction5.1.1 Drivers5.1.1.1 Consumer Awareness About the Health Benefits of Fortifying Agents and Increasing Focus on Preventive Healthcare5.1.1.2 Increasing Demand for Fortifying Agents in Dietary Supplements5.1.1.3 Increase in Application Profiling and Existing Applications Finding New Markets5.1.1.4 Increasing Cases of Chronic Diseases5.1.2 Restraints5.1.2.1 High Cost Involved in R&D Activities5.1.3 Opportunities5.1.3.1 Growing Applications of Food Fortifying Agents5.1.3.2 Technical Assistance by Governments5.1.3.3 Growing Demand from Emerging Economies5.1.4 Challenges5.1.4.1 Price Differences in Fortified Vs. Non-Fortified Products5.1.4.2 Multi-Page Labeling on the Rise

6 Industry Trends6.1 Introduction6.2 Supply Chain Analysis6.3 Key Industry Insights6.4 Porter's Five Forces Analysis6.4.1 Threat of New Entrants6.4.2 Threat of Substitutes6.4.3 Bargaining Power of Suppliers6.4.4 Bargaining Power of Buyers6.4.5 Intensity of Competitive Rivalry6.5 Key Conferences & Events in 2022-2023

7 Regulatory Framework7.1 Overview7.2 North America7.2.1 Canada7.2.2 US7.2.3 Mexico7.3 European Union (Eu)7.4 Asia-Pacific7.4.1 Japan7.4.2 China7.4.3 India7.4.4 Australia & New Zealand7.5 Rest of the World (Row)7.5.1 Brazil7.6 Dietary Trends7.6.1 Recommended Nutrient Intakes

8 Food Fortifying Agents Market, by Type8.1 Introduction8.2 Minerals8.2.1 Increasing Application of Minerals in Food Products due to Rising Health Benefits8.3 Vitamins8.3.1 Growing Consumer Awareness of Cardiovascular Health8.4 Lipids8.4.1 Rising Consumption of Omega-3 Fatty Acids to Reduce the Risk of Chronic Heart Diseases8.5 Carbohydrates8.5.1 Growing Application of Nutrients in Food & Beverage Products8.6 Proteins & Amino Acids8.6.1 Increasing Health Benefits of Proteins & Amino Acids to Support Market Growth8.7 Prebiotics8.7.1 Growing Preference for Natural Alternatives Over Conventional Medicines8.8 Probiotics8.8.1 Growing Application of Probiotics in Dietary Supplements8.9 Other Types8.9.1 Increasing Application of Other Food Fortifying Agents to Maintain Spine Health Supports Market Growth

9 Food Fortifying Agents Market, by Application9.1 Introduction9.2 Cereals & Cereal-Based Products9.2.1 Fortified Breakfast Cereals Play a Significant Role in Ensuring Nutritional Adequacy9.3 Dairy & Dairy-Based Products9.3.1 Enhances the Nutritional Value of Dairy & Dairy-Based Products9.4 Fats & Oils9.4.1 Increasing Popularity of Fortified Edible Oil Among Consumers9.5 Bulk Food Items9.5.1 Fortification of Bulk Food Items is an Appropriate Vehicle for Micronutrients9.6 Beverages9.6.1 There is Increasing Awareness Among Consumers Regarding Gut Health and Immunity9.7 Infant Formula9.7.1 Rising Economic Growth of Consumers with a Preference for Convenience Foods9.8 Dietary Supplements9.8.1 Growing Omega-3 Supplements' Demand due to Numerous Health Benefits9.9 Other Applications9.9.1 Increasing Focus on Feed, with Increased Opportunities in Dairy and Meat Industries, Contributes to the Growth of this Segment

10 Food Fortifying Agents Market, by Process10.1 Overview10.2 Types of Technologies and Processes Used in Food Fortification10.2.1 Powder Enrichment10.2.2 Premixes and Coatings10.2.3 Drum Drying10.2.4 Dusting10.2.5 Spray Drying Under the Microencapsulation Process

11 Food Fortifying Agents Market, by Region

12 Competitive Landscape12.1 Overview12.2 Market Share Analysis, 202112.3 Historical Revenue Analysis of Key Players12.4 Company Evaluation Matrix for Key Players12.4.1 Stars12.4.2 Pervasive Players12.4.3 Emerging Leaders12.4.4 Participants12.4.5 Food Fortifying Agents: Footprint, by Type (Key Players)12.5 Company Evaluation Matrix for Other Players12.5.1 Progressive Companies12.5.2 Starting Blocks12.5.3 Responsive Companies12.5.4 Dynamic Companies12.6 Competitive Scenario12.6.1 New Product Launches12.6.2 Deals12.6.3 Other Developments

13 Company Profiles13.1 Key Players13.1.1 Cargill13.1.2 Ingredion13.1.3 Tate & Lyle13.1.4 Dsm13.1.5 Arla Foods Amba13.1.6 Chr. Hansen Holding A/S13.1.7 Dupont13.1.8 Archer Daniels Midland Company13.1.9 Basf Se13.1.10 Nestle Sa13.1.11 Wenda Ingredients, LLC13.1.12 Royal Cosun13.1.13 Stratum Nutrition13.1.14 A&B Ingredients, Inc.

14 Adjacent and Related Markets

15 Appendix

For more information about this report visit https://www.researchandmarkets.com/r/7d71gb

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The Worldwide Food Fortifying Agents Industry is Expected to Reach $128 Billion by 2027 - PR Newswire

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The impact of Brexit on food supplements and specialized food products – Regulatory Focus

Posted: July 31, 2022 at 8:34 pm

| 27 July 2022 | By Sam Jennings, BSc, FIFST | 3499 This article examines the impact of diverging regulations and practices for food supplements and specialized food products since the UK left the EU market in 2020.Keywords Brexit, divergence, food supplements, UK, Northern IrelandBackground and introductionOn 23 June 2016, the UK, comprising England, Northern Ireland, Scotland, and Wales, held a referendum on whether the UK should remain in the EU or leave. Based on an overall majority of 51.9% on a turnout of 72.2%,1 the UK government decided to leave the EU (Table 1). This move became known as Brexit, a term derived from Britains exit (England, Scotland, and Wales, form Great Britain).After almost 5 years of discussion and negotiation between the UK and the EU, the UK officially left the EU on 31 January 2020, with a subsequent 11-month transition period ending on 31 December 2020. The UK had to implement all EU legislation published during those transitional 11 months but had no input into its preparation.Part of the negotiations with the EU focused on resolving the issue of Northern Irelands border with the Republic of Ireland, which would remain an EU member state. Neither country wanted to create a hard border between them and risk a recurrence of the decades-long conflict in Northern Ireland, known as "the Troubles and which had ended with the Good Friday agreement in 1998.2 To prevent a recurrence of the conflict, the UK and EU signed the Northern Ireland Protocol,3 which situated a border running roughly north-south through the Irish Sea, between Northern Ireland and GB, rather than having a hard border between the two countries.At the time of writing, in terms of most laws, including those relating to food, Northern Ireland has to continue to follow EU rules, but with no say in their production, whereas GB can follow its own rules. This means that businesses in GB that want to market their goods across the whole of the UK must comply with EU rules for the products that are shipped to Northern Ireland. Similarly, businesses from countries outside of the UK and EU that want to market their goods in the UK, must check their products compliance across two sets of rules, those for GB and those for the EU.When the transition period ended the EU legislation that had applied since 31 December 2020 was kept in GB and is referred to as retained EU law. This retained EU law continues to apply in GB, but future amendments can be made to it under UK rules. Although any such amendments apply only in GB, Northern Ireland has a voice in what the amendments will be. To add to the complications, food safety and standards are devolved matters in the UK, which means that each of its 4 member nations sets its own laws in these areas. The member nations have agreed upon the UK Common Frameworks4 to limit the potential for divergence within GB. However, the frameworks are nonlegislative arrangements for co-operation between the nations, so future internal divergence cannot be completely ruled out. Any EU laws that came into effect before 31 December 2020, but which applied from 1 January 2021 or later, do not apply in GB. Similarly, any amendments to EU legislation that have been made since 1 January 2021 do not apply in GB. However, all these laws apply in Northern Ireland.The immediate impact of BrexitThe effects of Brexit were felt by food businesses based in GB from day one, 1 January 2021, when foods that were to be exported to the EU, or moved to Northern Ireland, had to demonstrate compliance with all of the EUs sanitary and phytosanitary (SPS) controls5 and the label of the food product had to include a food business address based in Northern Ireland or one of the EUs 27 member states.Although the UK had been following all the SPS rules and moving their goods to the EU with no barriers until 31 December 2020, the EU border controls implemented full physical checks on all applicable consignments from GB from 1 January 2021. In terms of food (dietary) supplements and specialized food products, every product that contained an ingredient of animal origin that is, for which an ingredient, or the starting material for the ingredient, was originally sourced from an animal was affected. This had a direct impact on products containing ingredients such as milk powders, collagen, fish oils, or glucosamine, for example. The exporters of those products had to obtain a health certificate for the products being shipped and pre-notify the consignment to the border control post, where the consignment was stopped and checked at the EU border. The same system of health certification, prenotification, and checks at the border occurred for products shipped from GB to Northern Ireland. In the early days of 2021, there were numerous problems with certification; border rejections occurred regularly, owing to documentary errors; and the supply of some goods to Northern Ireland as well as to the EU was affected.6,7GB did not implement reciprocal border controls on goods entering from the EU after the transition period ended. Various dates were given, and subsequent postponements made, for GB border controls on EU goods during the nearly 16 months following Brexit, then, on 28 April 2022, the UK government announced8 that the entire system for GB border controls for all imports (EU and non-EU) would be revised. A target operating model is to be published in the fall of 2022, setting out the intended new regime of border import controls. The end of 2023 currently targeted as the revised introduction date for the new controls. Thus, at the time of writing, more than 18 months on from the UK leaving the EU, food products continue to enter GB from the EU with no barriers at the border.Regarding the food business address, within the UK and EU, the label of a food product must carry the address of the food business or importer who takes full responsibility for placing the product on the market. It has to be a physical address to which mail can be delivered. To market a food product in GB, the address can be based in any of the four UK member nations. However, as already noted, to market a food product in Northern Ireland, the address must be based in Northern Ireland or an EU member state. The UK put in place a transition period for the business address on food labels for products in GB, which comes to an end on 30 September 2022. Until that date, food products can be marketed with just an EU address on the label, but from 1 October 2022, food labels must also include a UK business address.9 However, the requirement for a Northern Ireland or EU member state address on the label for foods entering Northern Ireland or the EU from GB applied from 1 January 2021.Global impact of Brexit The impact of Brexit is also being felt globally as international businesses realize the rules for the UK and EU are no longer the same. There is divergence across a number of laws affecting food supplements and specialized food products, including the composition and labelling of those products and differences in the import requirements.One of the areas of divergence is in novel foods. Legislation on novel foods has been in force in the UK and EU for more than 25 years and requires that food ingredients entering the market after May 1997 must have official approval before they can be sold. The novel food Regulation (EU) 2015/228310 covers all products marketed under food law and differs from those in many countries outside the UK and EU, whereas Regulation (EU) 2017/247011 established the list of novel foods. At the time of writing, there had been 32 amendments to Regulation (EU) 2017/2470 since 1 January 2021, authorizing new novel foods, extending the permitted use of previously authorized foods, or revising other aspects relating to previously authorized foods (e.g., labelling requirements, specifications, etc.). During that time, the UK has made just one revision to the retained list,12 modifying one previously authorized novel food and adding four new novel foods to the list. Novel foods that have been authorized by the EU since 1 January 2021 can be included in foods intended for the EU market or for the Northern Ireland market. They cannot be used as ingredients in foods intended for the GB market until such time as authorization occurs also for GB. Thus, when marketing food supplements or specialized food products in the UK and EU, food businesses must ensure the ingredients they select are permitted in both regions and are used and labelled appropriately for the intended markets.Another area of divergence, which currently has most impact on food supplements, but where the impact is likely to extend into specialized food products, is that relating to the restriction or prohibition of certain nonmicronutrient ingredients used for nutritional or physiological purposes and known as other substances. These substances are controlled under Article 8 of Regulation (EC) 1925/200613 on the addition of vitamins and minerals and of certain other substances to foods, known as the fortified foods regulation. Most of this regulation does not apply to food supplements, but the controls on other substances apply to all foods including food supplements. Article 8 provides a procedure by which EU member states can submit to the European Commission for any substance for which there are safety concerns, supported by accompanying data demonstrating such concerns. Before Brexit, two substances, Ephedra species and Yohimbe (Pausinystalia yohimbe), had been prohibited for use in foods under the Article 8 procedure, and those prohibitions applied in GB, Northern Ireland, and the EU. However, since 1 January 2021, the EU has implemented prohibitions on the presence of hydroxyanthracene derivatives (HAD) in aloe preparations, and restrictions on the use of monacolins from red yeast rice. These prohibitions and restrictions apply in Northern Ireland and the EU, but not in GB. A number of other substances are currently going through the Article 8 process in the EU, with restrictions anticipated later in 2022 on the use of green tea catechins in foods. Meanwhile, GB is undertaking its own risk analyses of HAD, monacolins and green tea catechins, and the outcomes of these risk analyses will be seen in due course.Remaining with active ingredients, divergence has already occurred in relation to the vitamin and mineral sources that may be used in food supplements and in those permitted for use in certain specialized food products.Within the UK and EU, there are lists of vitamins and minerals that are allowed to be incorporated in food supplements and of the approved sources for those vitamins and minerals.14,15 If a vitamin or mineral is not on the list, it cannot be included in a food supplement (e.g., vanadium). In addition, if the source of a vitamin or mineral is not on the permitted list, it cannot be used. The EU has added two new sources to its permitted list since the UKs departure (nicotinamide riboside chloride and magnesium citrate malate),16 although they are yet to be added to the GB permitted list. Thus, food supplements containing these sources can be marketed in the EU and in Northern Ireland, but not currently in GB.There are similar lists of permitted vitamins, minerals, and their sources for general foods other than food supplements,17 but, at the time of writing, divergence had not yet occurred in those lists. However, certain specialized food products (i.e., food for infants and young children, for special medical purposes, and total diet replacement for weight control) have their own list of permitted vitamins and minerals, with their permitted sources.18 Divergence has occurred in the latter list regarding the permitted foods in which calcium-L-methylfolate can be used, with the EU extending its use to include infant and follow-on formula, baby food, and processed cereal-based food.19 This extension of use applies also in Northern Ireland, but within GB, this folate source can be used only in food for special medical purposes and for total diet replacement for weight control.Foods for infants and young children are not the only specialized food products for which Brexit has had a direct impact on the composition. When considering food products that replace the total diet for weight control, Delegated Regulation (EU) 2017/1798 implements some compositional changes and is due to apply in the EU and, thus, in Northern Ireland, from 27 October 2022. It will not, however, apply in GB. That said, because the UK government was fully involved and committed to the introduction of these changes while the UK was a member of the EU, the intention is to make legislation across GB that will mirror this delegated regulation as closely as possible. At the time of writing, it was not clear whether this GB legislation would be published by 27 October 2022.Increasing divergence is being seen in other compositional areas, with perhaps the highest profile being the recent EU ban on the use of the technological food additive E 171 titanium dioxide in foods.20 The transition period for implementation of the ban ends on 7 August 2022, after which no new food products containing titanium dioxide can be placed on the market in the EU or in Northern Ireland. However, the UK scientific committees did not agree with the European Food Safety Authoritys (EFSAs) conclusions about the risk titanium dioxide poses to consumers,21 and the UK is undertaking its own risk assessment of this food additive. The outcome of this assessment is expected in the first quarter of 2023. Meanwhile, foods containing titanium dioxide can continue to be placed on the GB market. There have been other revisions made by the EU to Regulation (EC) No 1333/200822 on food additives and to Commission Regulation (EU) No 231/2012,23 which presents specifications for food additives listed in Annexes II and III to Regulation (EC) No 1333/2008. At the time of writing, no revisions had been made to the retained versions of these regulations for GB.Divergence is also being seen in regard to: authorizations of genetically modified organisms (GMOs) or substances produced from GMOs;24,25 permitted flavoring substances for use in foods;26 the chemical contaminants for which controls are laid down and the maximum permitted levels for those contaminants in foods being placed on the market;27 and in the maximum residue levels for pesticides in food.28 Since the UK left the EU, numerous revisions have been made in all these areas by the EU, which apply also to Northern Ireland, but similar extensive revisions have not been occurring in relation to GB.Another area of compositional divergence that will be seen in coming months and years is the control of enzymes used for technological purposes in foods. Such enzymes are controlled by Regulation (EC) No. 1332/2008,29 but there is currently no list of authorized food enzymes. Applications for the EU list of enzymes are in the process of undergoing risk assessment by EFSA, whereas the European Commission has published an interim EU Public Registerof all food enzymes for which a valid application has been submitted.30 This register applies also in Northern Ireland. Meanwhile, the UK authorities have yet to issue a call for applications for a GB list, thus it is expected that the EU list of authorized food enzymes will be published long before that for GB. Once the EU list is in place, only food enzymes on that list will be permitted to be used for technological purposes for foods intended for the EU and Northern Ireland markets.In addition to compositional divergence, some of which has already been addressed in this article, divergence is starting to occur in the areas of food labelling and claims, affecting food supplements and specialized food products.The units that must be used for declaring the amounts of vitamins and minerals in food supplements are laid down in law.31,15 These are very similar to those for other foods, but one point of difference has been for copper, for which the designated unit was micrograms for food supplements, but milligrams for all other foods. After Brexit, the EU revised the legislation relating to food supplements, changing the unit for declaring copper to milligrams, so it is in line with all other foods.32 The UK has undertaken a limited technical consultation on changing the unit for copper, but the proposed legislation for implementing this change has yet to be published for public consultation. Thus, food supplements containing copper that are marketed across GB, Northern Ireland, and the EU currently require dual labelling, with the quantity declared as both micrograms and milligrams.In the health claims arena, the EU authorized a health claim for carbohydrate solutions in April 2021, stating, Carbohydrate solutions contribute to the improvement of physical performance during a high-intensity and long-lasting physical exercise in trained adults.33 This claim can be used on carbohydrate solutions that comply with the relevant conditions and restrictions of use and are marketed in the EU and in Northern Ireland. However, it cannot be used on such products in GB. To be used within GB, an application for the claim would have to be submitted to the UK authorities for assessment by the UK Nutrition and Health Claims Committee.34 If the application receives a positive opinion from the committee, it will then be discussed and agreed to by the four UK nations, then published as an official statutory instrument. At the time of writing, the original submitter of this health claim has not applied for its use within GB.Both the EU and the UK are looking at various issues that could affect the labelling of food supplements and/or certain specialized food products in the future. These include topics such as front-of-pack labelling, sustainability (eco) labelling, and precautionary allergen labelling. If any eventual proposals become mandatory, as opposed to voluntary, in either region, it will become increasingly difficult to have the same label on a product that is marketed across the whole of the UK and in the Republic of Ireland, even if the areas of compositional divergence can be resolved.ConclusionThe success of Brexit is currently open ended. There are numerous complexities associated with Brexit and its impact in some areas is only just becoming known. It is clear that divergence began on day one of Brexit and is increasing rapidly.Acronymns and abbreviationsGMOs, genetically modified organisms; HAD, hydroxyanthracene derivatives; SPS, sanitary and phytosanitary.

About the authorSam Jennings, BSc, FIFST, has worked at Berry Ottaway & Associates Ltd for more than 20 years. She provides advice to industry and governments globally on scientific, technical, and regulatory aspects of food, particularly supplements, specialized foods, and their ingredients. Jennings is a Fellow of the Institute of Food Science & Technology in the UK. She is chair of the UK governments Office for Product Safety & Standards Business Expert (Food Standards & Labelling) Group, and has been advising the Council for Responsible Nutrition UK on technical and regulatory matters for more than 15 years. Jennings can be reached at spj@berryottaway.co.ukDisclaimer This article reflects the personal opinion and experience of the author. It should not be construed as an official position by any organization with which the author is affiliated.Citation Jennings S. The impact of Brexit on food supplements and specialized food products. Regulatory Focus. Published online xx July 2022.ReferencesAll references were accessed and/or verified on xx July 2022.

2022Regulatory Affairs Professionals Society.

Im an RD and These Are the Supplements You Can Feel Good About Spending Your Money On – Well+Good

Posted: at 8:34 pm

If you feel like the drugstore's vitamins and supplements section is constantly expanding, you're not imagining it. The global dietary supplements market is expected to grow about nine percent between 2021 and 2028 to be worth a whopping $128 billion. With so many options to choose from (fish oil! omega-3s! vitamin A!), it's getting harder and harder to be a discerning consumer. Are those green horse pills hocked by your friendly neighborhood influencer actually life-changing? Do you really need to supplement all of the B vitamins?

While supplement labels may lure you into buying purchasing with big promises like "stress reduction" and "better sleep," it's important to be skeptical and do some preliminary research to see if a certain ingredient actually delivers on said promises. The U.S. Food and Drug Administration (FDA) does not approve vitamins and supplements; it simply inspects manufacturing practices and steps in if a certain supplement becomes a public health concern. So some companies make dubious claims and get away with it. One recent consumer review found that 46 percent of supplements don't keep their lofty promises.

Basically, it pays to be a Skeptical Susan when you're perusing the supplement aisle of the drugstore. But to make things a bit easier, we talked to registered dietitian and supplement researcher Anne Danahy, RDN, founder of Craving Something Healthy, and Kelly LeVeque, CN, a holistic nutritionist and best-selling author, to spill on what supplements you should consider adding to your cartand how to determine whether a product is actually right for you.

Dietitians are a big fan of telling you to "eat your vitamins," and Danahy is no exception. "[Everyone] should consider whether there are gaps in their diet that can be filled with food before turning to supplements," says Danahy. "The nutrients in whole foods are present in balanced amounts and as part of a whole package with protein, carbs, healthy fats, fiber, antioxidants, etc. All of these work synergistically in your body, so always start with a well-balanced diet." Basically, most people should try upping their intake of certain foods before resorting on a pill to make up the difference.

That said, certain people might struggle to meet their needs through diet alone, whether it's due to a health condition (like Celiac disease) or their particular eating plan. Vegans, for example, have more limited sources of brain-boosting B12 since it's most commonly found in animal foods. In cases like these, supplementation can be incredibly helpful to close nutritional gaps. Pregnant people should also take a folic acid supplement and other prenatal vitamins to support their baby's development and reduce the risk of birth defects.

Maybe you've heard that5-HTP can help you calm the heck down when you'remajorlystressing or that melatonin can support a good night's sleep. While there often is some evidence to support these touted benefits, it's essential to make sure you're addressing lifestyle factors that may also contribute to these issues, says Danahy. If work keeps you busy around the clock, for instance, can you try stress-management strategies like exercise, meditation, gardening, or reading before reaching for a supplement? If the answer is "no," that's totally finebut the question is worth asking.

"Even if someone is in good health, I'd recommend assessing their risk for certain health conditions because of their lifestyle or family history," says Danahy. "For example, someone with a family history of heart disease and blood pressure that's starting to creep up may want to think about omega-3 fish oil, beetroot powder, or certain antioxidants."

If this sounds like you, ask your doctor what they think about supplementation based on your personal family history. This isn't a one-size-fits-all situation.

According to Danahy, most folks could benefit from vitamin D. "It's hard to get enough from your diet unless you eat a lot of salmon, egg yolks, and fortified milk," she says. "This is also a vitamin that most people aren't deficient in, but many people have suboptimal levels."Vitamin D has many essential functions, including helping your body absorb calcium (which is critical for bone health), reducing inflammation, and promoting mental well-being. In other words, it's pretty darn importantand worth thinking about.

Daily recommended intake:600-800 IUs per day (15-20 mcg).

If you're living and breathing right now, you've probably heard the hype surrounding omega-3s. "Omega-3 or fish oil is another one I often recommend for middle age-plus. It can help reduce blood pressure and triglycerides, but I also like it because it supports cognitive health and has anti-inflammatory effects," says Danahy. She caveats that eating food sources of omega-3slike salmon, sardines, and fatty fish two to three times per weekwill still be a better option than supplementation.

Daily suggested intake: 1.1 grams for women; 1.6 grams for men (for reference, a 2-ounce serving of farmed salmon contains about 1.5 grams of omega-3s)

"[Magnesium] is involved in more than 300 biochemical reactions in your body, so it helps support everything from bones and muscles to glucose and blood pressure to DNA and RNA synthesis," says Danahy. "You can take it anytime, but some people feel it helps them relax in the evening if they take it after dinner." The mineral is also essential for heart health because it supports nerve, cell, and muscle health. She recommends magnesium glycinate, a form of magnesium that's slightly easier for the body to absorb. (FYI, magnesium appears in foods including spinach, black beans, and almonds.)

Daily suggested intake: 310-360 milligrams per day for women (depending on age and pregnancy), and 400-420 milligrams for men (depending on age).

LeVeque, for one, is a big fan of the multivitamin to cover all your bases. They can be a good way of consuming a variety of macro and micronutrients without paying for individual vitamins.

There's a caveat, though: Multivitamins come in many varieties, so you will need to consult a doctor, dietitian, or other trust health professional about which blend makes sense for you based on factors like your age, diet, current medications, and whether or not you're pregnant. Harvard Health recommends reading the label and choosing one that contains your daily recommended allowance of its various vitamins and minerals and features the United States Pharmacopeia (USP) seal of approval on the label (an indication of the purity and strength of a given vitamin).

Daily suggested intake:Varies per vitamin.

Long story short: Supplements aren't nearly as straightforward as they seem. So if you have lingering questions, make sure to check in with your primary care doctor. There's no use in spending big at the drugstore if it's not making a significant impact on your everyday health and well-being.

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Im an RD and These Are the Supplements You Can Feel Good About Spending Your Money On - Well+Good

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Widespread Use Of Collagen Hydrosylate In Nutritional Supplements Is Expected To Support The Growth Of The Market By 7.8% CAGR During Forecast Period….

Posted: at 8:33 pm

South Korea, Seoul, Aug. 01, 2022 (GLOBE NEWSWIRE) -- Fact.MR A Market Research and Competitive Intelligence Provider: The global collagen hydrosylate market is currently valued at US $ 1.09 Billion and expected to witness a CAGR of 7.8% to reach $ 2.34 Billion by the end of the forecast period.

Changing and evolving lifestyles, increased e-commerce platform penetration, surge in collagen demand for use in various wound healing therapies and aesthetic procedures is expected to boost the growth of the market.

Widespread use in nutritional supplements and surge in need for nutritious diets is expected drive the sales of the market. Besides this, climatic shifts and altered dietary patterns are contributing to various health issues for the people. Health-conscious consumers are predicted to have a good impact on the market.

Moreover, as per the Council for Responsible Nutrition, 68 percent of Americans use dietary supplements that include collagen hydrosylates. Also, consumption of collagen hydrosylate has increased throughout the region, especially in developed regions.

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In addition to this, demand for hydrolyzed collagen in the personal care sector is rising and consumers are inclined towards various ingredients including collagen hydrosylate to achieve glowing skin. Moreover, collagen hydrosylate is also widely used in anti-ageing products due to its hydrating and skin-healing properties.

Besides this, collagen hydrosylate is easy to combine with food products. Its easy to use feature is providing suppliers with significant market opportunities.

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Polymer Blends & Alloys Market Outlook (2022-2032) - The global polymer blends & alloys market was valued at around US$ 4.15 billion at the end of 2021, registering Y-o-Y growth of 3.5%. Demand for polymer blends & alloys is projected to increase at a CAGR of 6.4% to reach a market valuation of US$ 8 billion by 2032.

Metallized Films Market Outlook (2022-2032) - Global metallized film sales are currently valued at around US$ 2.44 billion. The metallized films market is anticipated to increase at a CAGR of 4.3% to reach a market valuation of US$ 3.72 billion by the end of 2032.

Magnesium Chloride Market Outlook (2022-2032) -The global magnesium chloride market reached a market size of US$ 1.4 billion at the end of 2021 and is predicted to expand at a CAGR of 6.3% to reach a market valuation of US$ 2.74 billion by 2032.

Polyethylene Furanoate (PEF) Market Outlook (2022-2032) - Global consumption of polyethylene furanoate is predicted to increase at a robust CAGR of 8.3% through 2032. As such, the global polyethylene furanoate (PEF) market is estimated to reach a valuation of US$ 76.7 million by 2032, up from US$ 32.7 million at the end of 2021.

Hexane Market Outlook (2022-2032) - The global hexane market is currently valued at US$ 2.21 billion and is slated to reach a revenue of US$ 3.05 billion by the end of 2032. Global demand for hexane is predicted to increase at a CAGR of 3.3% from 2022 to 2032.

Homosalate Market Outlook (2022-2032) - Expanding at a healthy 5.8% CAGR, the global homosalate market is expected to increase from a current market valuation of US$ 116.9 million to US$ 206 million by the end of 2032.

Melamine Formaldehyde Market Outlook (2022-2032) - The global melamine formaldehyde market is projected to increase from a valuation of US$ 645.1 million in 2022 to US$ 1.21 billion by the end of 2032, expanding at a CAGR of 6.5%.

Sludge Treatment Chemicals Market Outlook (2022-2032) - Worldwide consumption of sludge treatment chemicals is anticipated to rise at a CAGR of 4.4% from 2022 to 2032. At the end of 2021, the global sludge treatment chemicals market was valued at US$ 5.03 billion and is anticipated to reach a valuation of US$ 8.02 billion by 2032-end.

Silicone Release Coatings Market Outlook (2022-2032) - The silicone release coatings market experienced year-on-year (YoY) growth of 8.3% to reach a valuation of US$ 626.3 million at the end of 2021.

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Widespread Use Of Collagen Hydrosylate In Nutritional Supplements Is Expected To Support The Growth Of The Market By 7.8% CAGR During Forecast Period....

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Dietary Supplements Market Size is Anticipated to turn up USD 220.8 billion by 2027 – Yahoo Finance

Posted: at 8:33 pm

Market Leaders in Dietary Supplements Market are Increasing their Market Share Steadily Through Investments and Expansions.

CHICAGO, July 28, 2022 /PRNewswire/ -- According to MarketsandMarkets, the "Dietary Supplements Market by Function (Sports Nutrition, Additional Supplements, Medicinal Supplements), Target Consumer, Mode of Application, Type (Enzymes, Botanicals, Probiotics, Vitamins, Minerals, Amino Acids), and Region - Global Forecast to 2027", is estimated at USD 155.2 billion in 2022 and it is expected to reach USD 220.8 billion by 2027 growing at a compound annual growth rate (CAGR) of 7.3%.

Dietary Supplements Market

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Increasing awareness about nutrition and healthy lifestyles is driving the market for dietary supplements. It is widely known that having a healthy immune system can help reduce the risk or severity of diseases and infections. When combined with proper nutrition, dietary supplements can enhance the body's natural defenses and immunity. As people become more conscious of holistic wellbeing, the demand for immunity-boosting products is expected to increase in the coming years.

Browse in-depth TOC on"Dietary Supplements Market"

372 Tables 66 Figures348 Pages

The dietary supplements market consists of a few globally established players such as Amway Corp (US), Herbalife International of America, INC. (US), ADM (US), Pfizer INC (US), Abbott (US), Nestle (Switzerland), Otsuka Holding Co, LTD (Japan), H&H Group (China), Arkopharma (France), Bayer AG (Germany), Glanbia Plc (Ireland), Nature's Sunshine Products Inc (US), Fancl Corporation (Japan), Danisco (Denmark), Bionova (India), American Health (US), Pure Encapsulations LLC (US), GlaxoSmithKline, PLC (UK). Strategic partnerships were the dominant strategy adopted by the key players, followed by expansions and new product launches. These strategies have helped them to increase their presence in different regions and industrial segments.

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Herbalife Nutrition is a global nutrition firm that offers weight management, sports nutrition, and health & wellness products to people across the world. They distribute and advertise various nutrition products to and through a network of independent members, using a direct-selling business model. It offers dietary supplements under the Weight Management and Targeted Nutrition product categories. Herbalife Nutrition offers a wide range of high-quality and science-backed products, including meal replacement protein shakes, teas, aloes, protein bars, nutritional supplements, sports hydration, and outer nutrition products. Till now, the company has marketed and sold approximately 120 types of product. The company's manufacturing facilities, known as Herbalife Innovation and Manufacturing Facilities or HIMs, include HIM Lake Forest, HIM Winston-Salem, HIM Suzhou, and HIM Nanjing.

The Archer-Daniels-Midland Company (or ADM) harnesses the power of nature to offer nutrition to people all over the world. The corporation is a global leader in human and animal nutrition. ADM's breadth, depth, insights, facilities, and logistical expertise give it unparalleled capabilities to address food, beverage, health & wellness, and other needs. The company owns trademarks, brands, recipes, and other intellectual property, including patents, with a net book value of USD 903 million as of December 31, 2020. The company runs through four business segments: AG Services and Oilseeds, Carbohydrate Solutions, Nutrition, and Others. It offers dietary supplements under its Nutrition segment. The company's Nutrition segment engages in the manufacturing, sales, and distribution of a wide array of dietary supplements and nutrition products, including probiotics, prebiotics, enzymes, botanical extracts, and other specialty food & feed ingredients. The segment also includes activities such as the manufacturing of contract and private label pet treats and foods, as well as the processing and distribution of formula feeds and animal health and nutrition products. The company works through 46 innovation centers, 345 processing plants, 480 crop procurement facilities, and 200 bulk storage facilities in around 200 countries across the regions. ADM runs through numerous subsidiaries, such as Ab Mauri (UK), ABF Ingredients (UK), etc.

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Pfizer Inc. is a research-based, global biopharmaceutical company. Through the research, development, manufacturing, marketing, sale, and distribution of biopharmaceutical medicines around the world, the company employs science and its global resources to offer therapies to people that extend and significantly improve their lives. The company looks to promote wellness, prevention, treatments, and cures for the world's most feared diseases in both developed and emerging markets. On June 2, 1942, the company was incorporated under the laws of the State of Delaware. Pfizer manufactures medicines, vaccines, and consumer healthcare products, among others. The company works through two business segments, namely, Biopharma and Pfizer CentreOne. It offers consumer healthcare products, including multivitamins and calcium supplements, through brands Centrum and Caltrate, respectively, under the Consumer Healthcare segment. In 2019, Pfizer and GSK combined their respective consumer healthcare businesses into a JV that runs globally under the GSK Consumer Healthcare name. Some of the major subsidiaries of Pfizer are Pharmacia & Upjohn (Sweden), Pfizer Japan Inc. (Japan), Medivation (US), and Hospira (US).

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Personalized Nutrition Marketby Product Type (Active measurement, Standard measurement), Application (Standard supplements, Disease-based), End Use (Direct-to-consumer, Wellness & Fitness centers, Hospitals & Clinics), and Region - Global Forecast to 2025

Nutraceutical Products Marketby Type (Food, Beverages, Dietary Supplements), Source (Probiotics, Prebiotics, Vitamins, Minerals), Distribution Channel (Conventional Stores, Specialty Stores, Drugstores & Pharmacies), Region - Global Forecast to 2025

Browse Adjacent Reports: Food and Beverage Market Research Reports & Consulting

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Dietary Supplements Market Size is Anticipated to turn up USD 220.8 billion by 2027 - Yahoo Finance

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Vitamin B1 foods: Naturally high and enriched options – Medical News Today

Posted: at 8:33 pm

Vitamin B1 is another name for thiamine. Some foods, such as pork, salmon, and black beans, naturally contain this nutrient, while manufacturers enrich other foods with it.

Vitamin B1 is an essential nutrient. This means the body cannot make it and humans must get it from their diet. Like all the other B vitamins and vitamin C, it is a water-soluble vitamin.

The Recommended Dietary Allowance (RDA) of vitamin B1 for adults aged 19 years and up in the United States is 1.2 milligrams (mg) for males and 1.1 mg for females. The RDA increases to 1.4 mg during pregnancy and breastfeeding.

Some foods are naturally high in vitamin B1.

Individual vitamins within the B-vitamin group work together to exert health-promoting effects such as energy production. This is why many of these vitamin B1-rich foods contain a combination of the B vitamins and other nutrients.

Read on for a review of some key vitamin B1 foods to consider including in a diet.

A 100-gram (g) serving of broiled or baked pork chop contains 0.565 mg of vitamin B1.

A pork chop is also a source of vitamin B2 (riboflavin), vitamin B3 (niacin), vitamin B6 (pyridoxine), folate (vitamin B9), and vitamin B12 (cobalamin), as well as a range of essential minerals, including calcium, iron, magnesium, potassium, zinc, and selenium.

A 100-g serving of cooked wild Atlantic salmon has 0.275 mg of vitamin B1.

Salmon is also a source of all the B vitamins, vitamin A, and essential fatty acids, and it contains a range of essential minerals such as calcium, iron, magnesium, potassium, zinc, and selenium.

A 100-g serving of canned black beans contains 0.196 mg of vitamin B1.

Canned black beans are also a source of vitamin B2, vitamin B3, vitamin B6, folate, vitamin C, vitamin E, and vitamin K (phylloquinone). Additionally, they provide the essential minerals calcium, iron, magnesium, potassium, zinc, and selenium.

A 100-g serving of steamed mussels contains 0.303 mg of vitamin B1.

Steamed mussels also provide vitamin C, vitamin B2, vitamin B3, folate, vitamin B12, vitamin A, vitamin E, and vitamin K, along with the essential minerals calcium, iron, magnesium, potassium, zinc, and selenium.

A 100-g serving of cooked brown rice contains 0.177 mg of vitamin B1.

Cooked brown rice is also a source of vitamins B2, B3, B6, E, and K, as well as folate. It provides the essential minerals calcium, iron, magnesium, phosphorus, potassium, sodium, zinc, copper, and selenium.

Every 100 g of sunflower seeds contains 0.106 mg of vitamin B1.

Unsalted sunflower seeds also contain a range of other essential nutrients, including vitamins B2, B3, B6, C, E, and K; folate; and beta carotene. Additionally, they contain the minerals calcium, iron, magnesium, phosphorus, potassium, sodium, zinc, copper, and selenium.

A 100-g serving of green peas, cooked from frozen, contains 0.282 mg of vitamin B1.

Cooked frozen green peas also contain vitamins B2, B3, B6, C, E, and K, as well as folate and beta carotene. The body can potentially turn beta carotene into vitamin A.

Green peas provide the essential minerals calcium, iron, magnesium, phosphorus, potassium, sodium, zinc, copper, and selenium.

A 100-g serving of unsalted pecans contains 0.64 mg of vitamin B1.

Pecans also contain a range of other nutrients, including vitamins B2, B3, B6, C, E, and K; folate; and beta carotene. Additionally, pecans provide the essential minerals calcium, magnesium, iron, phosphorus, potassium, zinc, copper, and selenium.

Rather than being naturally high in vitamin B1, some vitamin B1 foods are high in the nutrient as a result of enrichment. Breakfast cereals and white rice are examples of these foods.

Brown rice naturally contains much more vitamin B1 than white rice. According to the National Institutes of Health (NIH), non-enriched white rice has only one-tenth of the vitamin B1 content of non-enriched brown rice. Food producers often enrich white rice with vitamin B1.

Around 80% of the vitamin B1 in an adults body takes the form of thiamine diphosphate (TDP). This form of vitamin B1 provides essential support to five enzymes stimulators of chemical reactions in the body needed to metabolize carbohydrates, protein, and fat.

Because of this important role in energy metabolism, vitamin B1 is also essential for cell growth, development, and function.

The body stores vitamin B1 in the liver, but in only small amounts (2530 mg). Vitamin B1 stays in the body for only a short time, so humans need to take in a continuous supply of it from food and, in some cases, from supplements.

Learn more about vitamin B1 here.

Vitamin B1, also known as thiamine, is an essential nutrient, meaning that humans need to get it from their diet to maintain good health.

Some foods, like pork and brown rice, are naturally high in vitamin B1. Food manufacturers enrich other foods, such as white rice and breakfast cereals, with vitamin B1.

This nutrient is important for energy metabolism and, therefore, for the growth, development, and functioning of cells.

See the article here:

Vitamin B1 foods: Naturally high and enriched options - Medical News Today

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Food Price Inflation and Health – JSTOR Daily

Posted: at 8:33 pm

Whatever the cause(s) of inflation in food priceseconomic crisis, supply chain chaos, the disruptions of war, corporate profiteeringthe effects can be quite grim. Especially amongst the poor.And especially amongst the poorest of the poor.

High and increasing food prices generate an immediate threat to the security of a familys food supply, thereby undermining population health, write scholars Hyun-Hoon Lee, Suejin A. Lee, Jae-Young Lim, and Cyn-Young Park. They analyzed a panel dataset that covered ninety-five developing countries between 2001, when global food prices were at a historic low, and 2011. This date range spans the startling upsurge of food prices in 2006 and the global food crisis of 2008 and its aftermath. Their lessons may be a window into the results of current and future global food price surges. As they note,

Rising food prices have a significant detrimental effect on nourishment and consequently lead to higher levels of both infant and child mortality in developing countries, especially in least developed countries (LDCs).

While this may seems obvious, especially for countries with precarious food securitypoverty and dependence on food importation are a dangerous combinationthe authors argue that their study was the first to attempt to assess the precise effects of food price inflation on child health in developing countries.

Short-term effects arent the only issue. In addition to the immediate threat to food security, malnutrition and undernutrition can retard human development and lower labor productively for the economy in the long term.

Fifty percent of childhood mortality is attributed to undernutrition. Maternal nourishment, meanwhile, is key to a childs development. Low birth weight, preterm birth, and intrauterine growth restriction (IUGR, also known as fetal growth restriction, FGR), all put babies at greater than-normal risk for a variety of health problems before and after birth. Such outcomes include increased risk to infectious disease, another reminder that public health depends on the health of all members of the public. Micronutrient deficiency is another factor to consider. Supplements of Vitamin A can reduce childhood mortality thirty percent and supplements of zinc van reduce the mortality of onethree-year-olds by eighteen percent.

Protecting the health status of infants and children in developing countries may become especially important during periods of concurrent economic downturn and high food price inflation, writes Lees team.

A governments strong commitment to public health is especially crucial to improving child health. The international communitys enhanced efforts to provide food and health aid to these countries are in great need during these difficult periods.

Bertolt Brechts infamous remark that famines do not occur, they are organized by the grain trade may be simplistic, but it does point to the truth that theres plenty of food in the world. Its the distribution of that food that is telling.

The research team studied developing countries, but their findings should be considered in light of conditions in the poorest regions of so-called developed countries, especially those marked by great wealth disparities, massive inequality, and undeveloped or nonexistent social safety nets. With consumer prices, including for food, reaching a four decade high in the US, and the continuing war in Ukraine undermining the global wheat market, the price of food isnt just a matter of politics. Its also health, welfare, and life itself.

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JSTOR is a digital library for scholars, researchers, and students. JSTOR Daily readers can access the original research behind our articles for free on JSTOR.

By: Hyun-Hoon Lee, Suejin A. Lee, Jae-Young Lim and Cyn-Young Park

The European Journal of Health Economics, Vol. 17, No. 5 (June 2016), pp. 535551

Springer

By: W. Thwaites

The Agricultural History Review, Vol. 33, No. 2 (1985), pp. 119131

British Agricultural History Society

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Dietary Supplements Market Size is Anticipated to turn up USD 220.8 billion by 2027 – Yahoo Finance

Vitamin B1 foods: Naturally high and enriched options – Medical News Today

Food Price Inflation and Health – JSTOR Daily

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