A key breakthrough came in the early 2000s, when Japanese researchers hit on a simple formula to turn any type of tissue into powerful stem cells, similar to ones in an embryo. Imaginations ran wild. Scientists realized they could potentially manufacture limitless supplies of nearly any type of cellsay, nerves or heart muscle.
In practice, though, the formula for producing specific cell types can prove elusive, and then theres the problem of getting lab-grown cells back into the body. So far, there have been only a few demonstrations of reprogramming as a way to treat patients. Researchers in Japan tried transplanting retina cells into blind people. Then, last November, a US company, Vertex Pharmaceuticals, said it might have cured a mans type 1 diabetes after an infusion of programmed beta cells, the kind that respond to insulin.
The concept startups are pursuing is to collect ordinary cells such as skin cells from patients and then convert these into hair-forming cells. In addition to dNovo, a company called Stemson (its name is a portmanteau of stem cell and Samson) has raised $22.5 million from funders including from the drug company AbbVie. Cofounder and CEO Geoff Hamilton says his company is transplanting reprogrammed cells onto the skin of mice and pigs to test the technology.
Both Hamilton and Lujan think there is a substantial market. About half of men undergo male-pattern baldness, some starting in their 20s. When women lose hair, its often a more general thinning, but its no less a blow to self-image.
These companies are bringing high-tech biology to an industry known for illusions. There are plenty of bogus claims about both hair-loss remedies and the potential of stem cells. Youve got to be aware of scam offerings, Paul Knoepfler, a stem-cell biologist at UC Davis, wrote in November.
JIYOON LEE AND KARL KOEHLER, HARVARD MEDICAL SCHOOL
So is stem-cell technology going to cure baldness or become the next false hope? Hamilton, who was invited to give the keynote at this years Global Hair Loss Summit, says he tried to emphasize that the company still has plenty of research ahead of it. We have seen so many [people] come in and say they have a solution. That has happened a lot in hair, and so I have to address that, he says. Were trying to project to the world that we are real scientists and that it's risky to the point I cant guarantee its going to work.
Right now, there are some approved drugs for hair loss, like Propecia and Rogaine, but theyre of limited use. Another procedure involves cutting strips of skin from someplace where a person still has hair and surgically transplanting those follicles onto a bald spot. Lujan says in the future, hair-forming cells grown in the lab could be added to a persons head with a similar surgery.
I think people will go pretty far to get their hair back. But at first it will be a bespoke process and very costly, says Karl Koehler, a professor at Harvard University.
Hair follicles are surprisingly complicated organs that arise through the molecular crosstalk between several cell types. And Koehler says pictures of mice growing human hair aren't new. Anytime you see these images, says Koehler, there is always a trick, and some drawback to translating it to humans.
Koehlers lab makes hair shafts in an entirely different wayby growing organoids. Organoids are small blobs of cells that self-organize in a petri dish. Koehler says he originally was studying deafness cures and wanted to grow the hair-like cells of the inner ear. But his organoids ended up becoming skin instead, complete with hair follicles.
Koehler embraced the accident and now creates spherical skin organoids that grow for about 150 days, until they are around two millimeters across. The tube-like hair follicles are clearly visible; he says they are the equivalent of the downy hair that covers a fetus.
One surprise is that the organoids grow backwards, with the hairs pointing in. You can see a beautiful architecture, although why they grow inside out is a big question, says Koehler.
The Harvard lab uses a supply of reprogrammed cells established from a 30-year-old Japanese man. But its looking at cells from other donors to see if organoids could lead to hair with distinctive colors and textures. There is absolutely demand for it, says Koehler. Cosmetics companies are interested. Their eyes light up when they see the organoids.
More here:
Going bald? Lab-grown hair cells could be on the way - MIT Technology Review
- 'Donald Trump Did This': How to Beat MAGA on Border Security - The Bulwark - April 29th, 2024 [April 29th, 2024]
- Potential Trump running mate JD Vance and Donald Trump Jr. have become so close that they text or talk on a 'nearly ... - Business Insider - April 29th, 2024 [April 29th, 2024]
- Trump Second Term: How the World and U.S. Allies Can Prepare for the Election - Foreign Policy - April 29th, 2024 [April 29th, 2024]
- Poll: Biden and Trump supporters sharply divided by the media they consume - NBC News - April 29th, 2024 [April 29th, 2024]
- Master Calendar of Trump Court Dates: Criminal and Civil Cases - Just Security - April 29th, 2024 [April 29th, 2024]
- Donald Trump's Sleepy, Sleazy Criminal Trial - The New Yorker - April 29th, 2024 [April 29th, 2024]
- Trump, GOP seize on campus protests to depict chaos under Biden - The Washington Post - April 29th, 2024 [April 29th, 2024]
- UK briefing: How Donald Trump plans to survive hush money trial with his campaign intact newsletter - The Guardian - April 29th, 2024 [April 29th, 2024]
- Opinion | We Are Talking About the Manhattan Case Against Trump All Wrong - The New York Times - April 29th, 2024 [April 29th, 2024]
- Election 2024: Biden jokes, Trump still leads and updates from the Sunday shows. - The New York Times - April 29th, 2024 [April 29th, 2024]
- Donald Trump Pans White House Correspondents' Dinner: 'Colin Jost BOMBED' - The Daily Beast - April 29th, 2024 [April 29th, 2024]
- Trump's Trial Could Bring a Rarity: Consequences for His Words - The New York Times - April 29th, 2024 [April 29th, 2024]
- Donald Trump Bemoans Really Bad WHCD, Biden & Colin Jost After All Mock Much Indicted Ex-POTUS - Deadline - April 29th, 2024 [April 29th, 2024]
- The Supreme Court's epic failure in dealing with Trump's cases - The Hill - April 29th, 2024 [April 29th, 2024]
- Donald Trump: In America's most important swing state, a key Biden group wants to hand the presidency to Trump. - Slate - April 29th, 2024 [April 29th, 2024]
- Donald Trump Is Being Ritually Humiliated in Court - The New Yorker - April 29th, 2024 [April 29th, 2024]
- Joe Biden trails Donald Trump in new national poll on 2024 election - USA TODAY - April 29th, 2024 [April 29th, 2024]
- Amid Cases on Abortion and Trump, Roberts Reflects on Supreme Court's Work - The New York Times - April 29th, 2024 [April 29th, 2024]
- Donald Trump Is Used to the Finer Things in Life. At the Courthouse, 'He's Miserable.' - The Wall Street Journal - April 29th, 2024 [April 29th, 2024]
- How Trumps Rhetoric at Rallies Has Escalated - The New York Times - April 29th, 2024 [April 29th, 2024]
- The Supreme Court Appears Poised to Protect the Presidencyand Donald Trump - The New Yorker - April 29th, 2024 [April 29th, 2024]
- The Supreme Court seems divided over Donald Trump's immunity - The Economist - April 29th, 2024 [April 29th, 2024]
- John Dean Says 1 Thing 'Keeping Me On The Edge Of My Seat' In Trump Trial - Yahoo! Voices - April 29th, 2024 [April 29th, 2024]
- Five Moments That Have Defined Donald Trump's Trial So Far - The New York Times - April 29th, 2024 [April 29th, 2024]
- How Trumps trial is playing, politically - The Washington Post - April 29th, 2024 [April 29th, 2024]
- Opinion | The Ukraine aid vote helps, but U.S. allies complacency would be unwise - The Washington Post - April 29th, 2024 [April 29th, 2024]
- Hey, SCOTUS your hypocrisy is showing - The Hill - April 29th, 2024 [April 29th, 2024]
- Bill Barr Is Happy to Debase Himself for Donald Trump Again Mother Jones - Mother Jones - April 29th, 2024 [April 29th, 2024]
- The Supreme Court is likely to place Donald Trump above the law in its immunity case - Vox.com - April 29th, 2024 [April 29th, 2024]
- RFK is openly gunning for Trump voters now and Republicans are starting to worry - Salon - April 29th, 2024 [April 29th, 2024]
- Trump Pushes Immigration Conspiracy Theories and Mass Deportations - The New York Times - February 5th, 2024 [February 5th, 2024]
- Nikki Haley makes surprise appearance on SNL, mocking Donald Trump and Joe Biden - NPR - February 5th, 2024 [February 5th, 2024]
- Trump feud with UAW reaches fever pitch - The Hill - February 5th, 2024 [February 5th, 2024]
- Donald Trump tightens his grip on GOP, bolsters ties with Mike Johnson - USA TODAY - February 5th, 2024 [February 5th, 2024]
- 1/31/24 - 2024 Matchups: Biden Opens Up Lead Over Trump In Head-To-Head, Quinnipiac University National Poll ... - Quinnipiac University Poll - February 5th, 2024 [February 5th, 2024]
- Here's how 2 sentences in the Constitution rose from obscurity to ensnare Donald Trump - Yahoo News - February 5th, 2024 [February 5th, 2024]
- Donald Trump floats tariff of more than 60% on imports from China and denies it would start a trade war - Fortune - February 5th, 2024 [February 5th, 2024]
- Jeffries on House Republicans: Wholly owned subsidiaries of Donald Trump - The Hill - February 5th, 2024 [February 5th, 2024]
- Ex-DOJ Official Says He's 'Now At The Freakout Stage' Over 1 Donald Trump Case - Yahoo News - February 5th, 2024 [February 5th, 2024]
- Nikki Haley to GOP: Let's wait to see if Donald Trump is convicted - USA TODAY - February 5th, 2024 [February 5th, 2024]
- Why Supreme Court appeal will be no 'open mic night' for Donald Trump - USA TODAY - February 5th, 2024 [February 5th, 2024]
- Nikki Haley hits Donald Trump during 'SNL' sketch ahead of SC primary - USA TODAY - February 5th, 2024 [February 5th, 2024]
- Donald Trump's legal fees are draining his campaign funds - The Economist - February 5th, 2024 [February 5th, 2024]
- Donald Trump Mentions These Names When Asked About Vice Presidential Picks - NDTV - February 5th, 2024 [February 5th, 2024]
- Trump's lead over Biden may be smaller than it looks - The Economist - February 5th, 2024 [February 5th, 2024]
- Tory rising star described Donald Trump as 'refreshing' - The Independent - February 5th, 2024 [February 5th, 2024]
- Joe Biden v Donald Trump - where contest will be won and lost - BBC.com - February 5th, 2024 [February 5th, 2024]
- Donald Trump's fed trial on election interference postponed from March - USA TODAY - February 5th, 2024 [February 5th, 2024]
- Inside Trump's growing influence over congressional Republicans - POLITICO - POLITICO - February 5th, 2024 [February 5th, 2024]
- Federal judge postpones Trump's March 4 election interference trial - NPR - February 5th, 2024 [February 5th, 2024]
- Trump Says He Would Not Reappoint Powell as Fed Chair if Elected - Bloomberg - February 5th, 2024 [February 5th, 2024]
- I Prosecuted Donald Trump and Won. Here's How It's Done. - The Daily Beast - February 5th, 2024 [February 5th, 2024]
- Donald Trump Loses London Case Against Ex-MI6 Spy Over Kremlin Dossier - Bloomberg - February 5th, 2024 [February 5th, 2024]
- After Speedy Start, Appeals Court Slows Down on Trump Immunity Decision - The New York Times - February 5th, 2024 [February 5th, 2024]
- Donald Trump and UAW President Shawn Fain exchange barbs: 'Get rid of this dope' - USA TODAY - February 5th, 2024 [February 5th, 2024]
- Donald Trump dispels rumors that he reached out to RFK Jr for VP: Never happened - Fox News - February 5th, 2024 [February 5th, 2024]
- How Donald Trump Got Disqualified From The Ballot And His Entire Candidacy Wound Up Before The Supreme Court - HuffPost - February 5th, 2024 [February 5th, 2024]
- Trump Says Nikki Haley Is Unlikely to Be His Running Mate - The New York Times - January 20th, 2024 [January 20th, 2024]
- Donald Trump Goes From Calm To Indignant In Newly Released Deposition Video Of Civil Fraud Lawsuit - HuffPost - January 20th, 2024 [January 20th, 2024]
- Trump: Haley 'probably ... is not going to be chosen as the vice president' - POLITICO - January 20th, 2024 [January 20th, 2024]
- Trump returns to New Hampshire as primary nears - The Washington Post - January 20th, 2024 [January 20th, 2024]
- Boris Johnson: Trump's return could be 'big win for the world' - POLITICO Europe - January 20th, 2024 [January 20th, 2024]
- Zelenskyy invites Trump to Kyiv POLITICO - POLITICO Europe - January 20th, 2024 [January 20th, 2024]
- 'New Hampshire Is Close to a Make-or-Break for Keeping the Nomination Out of Donald Trump's Hands.' - POLITICO - January 20th, 2024 [January 20th, 2024]
- Trump's pitch in New Hampshire is more about Nikki Haley as he hopes for big win - NPR - January 20th, 2024 [January 20th, 2024]
- Donald Trump's tax cuts would add to American growthand debt - The Economist - January 20th, 2024 [January 20th, 2024]
- Donald Trump's populism is turning off corporate donors - The Economist - January 20th, 2024 [January 20th, 2024]
- Why DeSantis Says Trump's Romp in Iowa Is Actually a Sign of His Weakness - The New York Times - January 20th, 2024 [January 20th, 2024]
- The GOP Is Already Clashing Over Trump's VP Pick - POLITICO - January 20th, 2024 [January 20th, 2024]
- There is still a way to stop Donald Trump but time is running out - The Guardian - January 20th, 2024 [January 20th, 2024]
- The Davos Consensus: Donald Trump Will Win Re-Election - The New York Times - January 20th, 2024 [January 20th, 2024]
- Maine Secretary of State to Appeal Ruling on Her Decision to Exclude Trump From Ballot - The New York Times - January 20th, 2024 [January 20th, 2024]
- Vice President Harris says she's 'scared as heck' that Donald Trump could win - The Associated Press - January 20th, 2024 [January 20th, 2024]
- What is the point of coming second to Donald Trump? - The Economist - January 20th, 2024 [January 20th, 2024]
- Thousands Sign Christian Petition Urging Bishops Not to Back Donald Trump - Newsweek - January 20th, 2024 [January 20th, 2024]
- Why Donald Trump Is Facing E. Jean Carroll in Court a Second Time - The New York Times - January 20th, 2024 [January 20th, 2024]
- Donald Trump Claims He Will Never Allow Creation of CBDC in the US if Reelected - Yahoo Finance - January 20th, 2024 [January 20th, 2024]
- Keller @ Large: What Donald Trump's win in Iowa means for the presidential race - CBS Boston - January 20th, 2024 [January 20th, 2024]
- Donald Trump tries to twist felony charges, lawsuits after Iowa win - USA TODAY - January 20th, 2024 [January 20th, 2024]
- Donald Trump Just Incriminated Himself on Truth Social: Legal Analyst - Newsweek - January 20th, 2024 [January 20th, 2024]