A child and a dog run along a beach in Haiti, from where health workers appear to have contracted a new coronavirus. Around the world, in Malaysia, a similar coronavirus has been found apparently being passed to humans from dogs. Hector Retamal/AFP via Getty Images hide caption
A child and a dog run along a beach in Haiti, from where health workers appear to have contracted a new coronavirus. Around the world, in Malaysia, a similar coronavirus has been found apparently being passed to humans from dogs.
Early in 2017, a team of medical personnel, including doctors, nurses and volunteers, returned home to Florida after volunteering at a clinic in Haiti. Soon after their return, 20 members of the team began to feel a bit under the weather.
"They had a slight fever and didn't feel 100% right," says virologist John Lednicky at the University of Florida. "But they weren't very sick."
At the time, Zika virus was circulating in Haiti, and health officials were worried the travelers might have been infected, potentially importing the mosquito-borne illness to Florida. So officials took urine samples from each traveler and asked Lednicky to test for Zika.
Lednicky ran the standard PCR tests for the virus, and they all came back negative. But he wasn't satisfied. He had a hunch that the urine samples did contain a virus not Zika but something else.
So he took a little bit of the urine from six of the travelers and added it to a special solution of monkey cells. The goal was deceptively simple: to see if any viruses in the urine would infect the monkey cells, start replicating and grow to detectable levels. Then Lednicky could collect the virus's genes and identify it.
"This is what we do in our lab," Lednicky says. "We cast a wide net. We try to isolate viruses. And oftentimes, when we do that, the unexpected happens."
Indeed, the unexpected occurred.
"We found a coronavirus," he says. And not just any coronavirus, but one that many scientists believe may be a new human pathogen likely the eighth coronavirus known to cause disease in people. Turns out, this coronavirus in the Haiti travelers has cropped up previously, on the other side of the globe.
Back in May, scientists at Duke University reported they had detected a nearly identical virus coronavirus in children at a Malaysian hospital.
The researchers found the virus in the upper respiratory tract of 3% of the 301 patients they tested in 2017 and 2018.
The genetic sequence of the Malaysian virus suggested it likely originated in dogs and then jumped into people. "The majority of the genome was canine coronavirus," virologist Anastasia Vlasova told NPR in May.
Although the findings sounded alarming, the researchers had no evidence that the virus could spread among people or that it was widespread around the world.
"These human infections with ... canine coronaviruses appear to be isolated incidents which did not lead to extensive human transmission," virologist Vincent Racaniello wrote on the Virology Blog.
Now Lednicky and his colleagues have found an almost identical virus infecting people 11,000 miles away at the same time. The genetic sequence of the virus in Haiti is 99.4% identical to the one in Malaysia. Lednicky and his colleagues reported this past Sunday in the journal Clinical Infectious Diseases.
And the big question is: How does a dog virus in Malaysia wind up in doctors and nurses in Haiti?
"The virus probably circulates widely, but no one has paid attention to it," Lednicky says. He suspects it's all over the world. And if you've been around dogs frequently, you might have been infected with this virus or developed an immunity to it by exposure to similar virus. "We'll know when scientists start looking for antibodies inside older blood samples taken from patients with respiratory disease. How many of them were misdiagnosed all along?"
Some scientists also think doctors and researchers should start actively looking for this virus in patients. "I think that's important for several reasons," says virologist Linda Saif at Ohio State University, who has studied coronaviruses for about 40 years.
"No. 1, this virus has been associated with a number of pneumonia cases in children, and No. 2, we really don't know if it can transmit from human to human," she adds.
The fact that scientists detected the almost-identical viruses in both Haiti and Malaysia, at the same time, suggests the virus does spread among people, Saif says.
"There's a temporal sequence here. These two viruses which are very, very similar have been detected in a similar time frame but in widely separated regions of the world," she explains. That could happen if a nearly-identical virus was circulating in dogs in both Haiti and Malaysia and then jumped over to people in both countries during the same year.
"I would be very surprised if that happened," Saif says.
The second hypothesis is that the virus is circulating in people, at low levels, in many parts of the world, under the radar. "That hypothesis is more likely," Saif says.
If that hypothesis turns out to be true, this canine coronavirus will be the eighth coronavirus known to spread among humans.
On the surface, these new findings sound like horrible news. The last thing the world needs right now is another coronavirus one that may trigger pneumonia in children. But Jonna Mazet says it's actually good news because it means scientists have caught this virus before it has caused a big problem.
"The very exciting part is that people are starting to do virus discovery and characterization, even when large groups of people aren't dying and or getting severely ill, which is how most virus discovery has happened in the past," says Mazet, who's an epidemiologist at the University of California, Davis and the founding executive director of the One Health Institute there.
By finding this virus early, scientists now have time to study it, create tools to diagnose it and understand what it might take to stop it. Although it's not a cause for deep concern at this time, there's always the risk the virus could evolve and become a bigger problem, Mazet says, as was likely the case with SARS-CoV-2, which causes COVID-19.
"Almost certainly, SARS-CoV-2 was circulating for quite some time and making people either a tiny bit sick or not sick enough to be noticed," she says. If scientists had detected it at this stage, perhaps the world would have had time to develop a test for it, some promising treatments and even a preliminary vaccine. Perhaps the pandemic would have taken a much different perhaps less deadly course.
"We need to find these novel viruses well before they fully adapt to humans and become a pandemic problem," writes epidemiologist Gregory Gray, from the University of Texas Medical Branch, in an email to NPR. "Fortunately, today we have the tools to both detect and evaluate the risk of such novel viruses. We just need the political will and financial support to do so."
Read the original here:
- 2024 CDC COVID-19 guidelines: Isolation, masks, what you should know - The Arizona Republic - February 29th, 2024 [February 29th, 2024]
- Long Covid and Impaired Cognition More Evidence and More Work to Do | NEJM - nejm.org - February 29th, 2024 [February 29th, 2024]
- Prospective Memory Assessment before and after Covid-19 | NEJM - nejm.org - February 29th, 2024 [February 29th, 2024]
- A pandemic that won't go away as COVID enters its 5th year, NZ needs a realistic strategy - The Conversation - February 29th, 2024 [February 29th, 2024]
- Older US adults should get another COVID-19 shot, advisers say - Detroit News - February 29th, 2024 [February 29th, 2024]
- Vaping increases susceptibility to COVID-19 infection, study finds - News-Medical.Net - February 29th, 2024 [February 29th, 2024]
- Older U.S. adults should get another covid-19 shot, advisers say - TribLIVE - February 29th, 2024 [February 29th, 2024]
- Vapers More Susceptible to COVID-19 Infection Than Tobacco Smokers, Reveals Study | Weather.com - The Weather Channel - February 29th, 2024 [February 29th, 2024]
- How we met: She was in the next hospital bed and I loved her accent - The Guardian - February 29th, 2024 [February 29th, 2024]
- Fleet To Hit Record Size In 2024 But Still Suffering Covid Hangover - Forbes - February 29th, 2024 [February 29th, 2024]
- How vaccine hesitancy is contributing to rising rates of measles and COVID - PBS NewsHour - February 29th, 2024 [February 29th, 2024]
- How did COVID-19 impact cancer incidence trends in the US? - News-Medical.Net - February 29th, 2024 [February 29th, 2024]
- CT-based Assessment at 6-Month Follow-up of COVID-19 Pneumonia patients in China | Scientific Reports - Nature.com - February 29th, 2024 [February 29th, 2024]
- Covid in 2024: What to Know About Guidelines, Symptoms and Vaccines - WSJ - The Wall Street Journal - February 29th, 2024 [February 29th, 2024]
- Unlocking coronavirus structure through M protein research - News-Medical.Net - February 29th, 2024 [February 29th, 2024]
- SARS-CoV-2 fragments may cause problems after infection - National Institutes of Health (NIH) (.gov) - February 29th, 2024 [February 29th, 2024]
- People 65 and up should now get another COVID-19 vaccine, CDC recommends - cleveland.com - February 29th, 2024 [February 29th, 2024]
- Welcome to the 2024 CFA Annual Report | Covid-19 | news-journal.com - Longview News-Journal - February 29th, 2024 [February 29th, 2024]
- Exploring the reported adverse effects of COVID-19 vaccines among vaccinated Arab populations: a multi-national ... - Nature.com - February 29th, 2024 [February 29th, 2024]
- R.I. COVID-19 cases increased by 337 last week, with 2 deaths - Providence Business News - February 29th, 2024 [February 29th, 2024]
- Older US adults should get another COVID-19 shot, advisers say - NBC Bay Area - February 29th, 2024 [February 29th, 2024]
- Cognitive Deficits Seen in COVID-19 Patients Regardless of Symptom Duration - HealthDay - February 29th, 2024 [February 29th, 2024]
- CDC recommends seniors get another Covid-19 shot - Baltimore Sun - February 29th, 2024 [February 29th, 2024]
- Odds of Severe COVID-19 High for Hematologic Cancer Patients During Pandemic - HealthDay - February 29th, 2024 [February 29th, 2024]
- COVID-19 may have small but lasting effects on cognition and memory | Imperial News - Imperial College London - February 29th, 2024 [February 29th, 2024]
- More free home COVID-19 tests available from US government - WCVB Boston - November 20th, 2023 [November 20th, 2023]
- Seniors made up 63 percent of covid hospitalizations earlier this year - The Washington Post - November 20th, 2023 [November 20th, 2023]
- Fifth Covid-19 wave sees biggest bump in virus detection since ... - New Zealand Herald - November 20th, 2023 [November 20th, 2023]
- KFF COVID-19 Vaccine Monitor November 2023: With COVID ... - KFF - November 20th, 2023 [November 20th, 2023]
- What to Know About the New Dominant Covid Variant - The New York Times - August 12th, 2023 [August 12th, 2023]
- Should You Get Another Covid Booster Now, or Wait Until the Fall? - The New York Times - August 12th, 2023 [August 12th, 2023]
- A 'mini cyclone' helps detect coronavirus in the air - Science News Explores - August 12th, 2023 [August 12th, 2023]
- Infection prevention and control in the context of coronavirus ... - World Health Organization - August 12th, 2023 [August 12th, 2023]
- Serum ferritin level during hospitalization is associated with Brain ... - Nature.com - August 12th, 2023 [August 12th, 2023]
- Rhode Island Man Sentenced to Three Years in Prison for Theft and ... - Department of Justice - August 12th, 2023 [August 12th, 2023]
- Posts Exaggerate Significance of Swiss Study on Heart Risk and ... - FactCheck.org - August 12th, 2023 [August 12th, 2023]
- Wenstrup Presses Department of Education for Answers on Misuse ... - House Committee on Oversight and Reform | - August 12th, 2023 [August 12th, 2023]
- Biden Administration Fails to Share Intel on COVID-19 Origins, but Independent Evidence Is Piling Up - Heritage.org - June 24th, 2023 [June 24th, 2023]
- Do I need a booster vaccine if I recently had COVID? What if I'm not sure what I had? - The Conversation - June 24th, 2023 [June 24th, 2023]
- Psychics, wrestlers and churches: How online shopping and Covid changed mall tenants - Buffalo News - June 24th, 2023 [June 24th, 2023]
- Report: Incarcerated populations up 4% post-COVID - CorrectionsOne - June 24th, 2023 [June 24th, 2023]
- The National Average for Gross Revenue at ECP Locations Decreased for the Week of June 12 18, Jobson's Latest ... - Vision Monday - June 24th, 2023 [June 24th, 2023]
- ODNI Releases Report on the Potential Links Between the Wuhan ... - Office of the Director of National Intelligence - June 24th, 2023 [June 24th, 2023]
- U.S. Intelligence Agencies May Never Find Covid's Origins, Officials ... - The New York Times - June 24th, 2023 [June 24th, 2023]
- Covid-19 likely came from lab leak, says news report citing US energy ... - March 4th, 2023 [March 4th, 2023]
- Classified Energy Department report finds lab leak likely cause of ... - March 4th, 2023 [March 4th, 2023]
- Mayor Kirk Watson tests positive for COVID-19 - KEYE TV CBS Austin - February 5th, 2023 [February 5th, 2023]
- Biden's plan for ending the emergency declaration for COVID-19 signals a pivotal point in the pandemic 4 questions answered - The Conversation... - February 5th, 2023 [February 5th, 2023]
- Study finds one habit can significantly lower your odds of getting sick from COVID-19 - KATU - February 5th, 2023 [February 5th, 2023]
- How will life change once the COVID-19 emergency ends? - KFOX El Paso - February 5th, 2023 [February 5th, 2023]
- Shipping Corporation of India and Seven Islands Shipping re-join membership of INSA - ETInfra.com - January 30th, 2023 [January 30th, 2023]
- COVID-19 Response | United Nations - December 28th, 2022 [December 28th, 2022]
- Top German virologist says COVID-19 pandemic is over - Hindustan Times - December 28th, 2022 [December 28th, 2022]
- China says impossible to track COVID spread as virus surges - Al Jazeera English - December 14th, 2022 [December 14th, 2022]
- What are the most common COVID symptoms now? Its no longer fever, loss of taste - AL.com - December 14th, 2022 [December 14th, 2022]
- Entropy and life - Wikipedia - November 27th, 2022 [November 27th, 2022]
- Negentropy - Wikipedia - November 27th, 2022 [November 27th, 2022]
- Coronavirus: OC reported 1,602 new cases and six more deaths over the past week, as of Nov. 17 - OCRegister - November 19th, 2022 [November 19th, 2022]
- How COVID-19 damages lungs: The virus attacks mitochondria, continuing an ancient battle that began in the primordial soup - The Conversation - October 30th, 2022 [October 30th, 2022]
- How to save this winter on heating costs - WKYC.com - October 23rd, 2022 [October 23rd, 2022]
- 'Fonseca' book review: The Goan artist's biography misses the art of the matter - The New Indian Express - October 23rd, 2022 [October 23rd, 2022]
- Researchers' tests of lab-made version of Covid virus draw scrutiny - STAT - October 21st, 2022 [October 21st, 2022]
- Coronavirus: Orange County reported 1,427 more cases and seven more deaths in the past week as of Oct. 20 - OCRegister - October 21st, 2022 [October 21st, 2022]
- 3 Illinois Counties at High Community Level for COVID-19 as 1 Million Bivalent Booster Shots Have Been Administered - NBC Chicago - October 21st, 2022 [October 21st, 2022]
- What Is Coronavirus? | Johns Hopkins Medicine - October 17th, 2022 [October 17th, 2022]
- Gaston County reported 177 additional COVID-19 cases this week - Gaston Gazette - October 17th, 2022 [October 17th, 2022]
- Coronavirus Roundup: The Biden Administration Renews the Public Health Emergency for COVID-19 - GovExec.com - October 17th, 2022 [October 17th, 2022]
- Circulation of Public Warning Alert on COVID-19 vaccines fraudulently using PAHO's name and logo - World - ReliefWeb - October 17th, 2022 [October 17th, 2022]
- Time to Get Your Flu Shot and Your COVID-19 Booster Too - Health.mil - October 17th, 2022 [October 17th, 2022]
- Evasive COVID-19 subvariants that you dont know about are spreading fast - Poynter - October 17th, 2022 [October 17th, 2022]
- Deer and mink can harbor Covid-19: Why animal virologists say we need to worry - Inverse - October 17th, 2022 [October 17th, 2022]
- Europe likely entering another COVID wave, says WHO and ECDC - Reuters - October 17th, 2022 [October 17th, 2022]
- Without a nasal vaccine, the U.S. edge in fighting Covid is on the line - POLITICO - October 17th, 2022 [October 17th, 2022]
- COVID-19 Daily Update 10-17-2022 - West Virginia Department of Health and Human Resources - October 17th, 2022 [October 17th, 2022]
- Coronavirus: Government seeking to extend powers behind COVID restrictions until 2025 - Newshub - October 17th, 2022 [October 17th, 2022]
- Shocking: EcoHealth Alliance receives another round of funding for coronavirus bat research in Asia - The Center Square - October 17th, 2022 [October 17th, 2022]
- Opportunities in Health Education in the Post-COVID-19 Era: Transforming Viral to Vital - Cureus - October 17th, 2022 [October 17th, 2022]
- Fauci says COVID-19 was politicized by triple whammy of outbreak, division and 2020 election - WJTV - October 17th, 2022 [October 17th, 2022]
- How long does immunity from the new COVID bivalent boosters last 'in the real world'? - San Francisco Chronicle - October 17th, 2022 [October 17th, 2022]
- Respiratory illnesses have spiked among children. Here's what parents need to know. - Yahoo News - October 17th, 2022 [October 17th, 2022]