Daily Archives: December 26, 2022

TikTok owner ByteDance takes first step into virtual reality with …

Posted: December 26, 2022 at 10:34 pm

A visitor tries out a VR headset at the booth of Pico Technology during the China 5G and Industrial Internet Conference on Nov. 19, 2020 in Wuhan, Hubei Province of China. ByteDance has made its first foray into virtual reality (VR) through the acquisition of start-up Pico.

Zhang Canlong | Visual China Group | Getty Images

GUANGZHOU, China TikTok owner ByteDance has made its first foray into virtual reality (VR) through the acquisition of a start-up called Pico.

Beijing-headquartered ByteDance did not disclose the size of the deal but said in a statement that Pico's "comprehensive suite of software and hardware technologies, as well as the talent and deep expertise of the team, will support both our entry to the VR space and long-term investment in this emerging field."

Pico was the third-largest virtual reality headset maker globally in the first quarter of 2021, with shipments growing 44.7% year-on-year, according to IDC.

ByteDance found success with short video app TikTok and Chinese version Douyin, as well as news aggregation app Toutiao.

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Two biotech CEOs charged with defrauding investors – UPI.com

Posted: at 10:30 pm

The Justice Department announced Tuesday that two biotech chief executive officers have been indicted for their roles in defrauding investors in CytoDyn, a company developing an investigational drug to treat human immunodeficiency virus, or HIV. File photo by Bonnie Cash/UPI | License Photo

Dec. 20 (UPI) -- Two biotech chief executive officers have been indicted for their roles in defrauding investors in CytoDyn, a company developing an investigational drug to treat human immunodeficiency virus, or HIV, according to a federal grand jury in the District of Maryland.

The court documents, unsealed on Tuesday, show Nader Pourhassen, of Lake Oswego, Ore., and Kazem Kazempour, of Potomac, Md., allegedly conspired to defraud investors through "false and misleading representations" relating to CytoDyn's development of the drug leronlimab.

"Leronlimab is a humanized monoclonal antibody that is a once-a-week subcutaneous injection that can also be administered intravenously," according to CytoDyn, which is based in Vancouver, Wash. "The platform drug is used for various therapeutic indications, including NASH, NASH/HIV, oncology and HIV."

Pourhassen, 59, was CytoDyn's president and CEO at the time of the alleged fraud. Kazempour, 69, is the co-founder, president and CEO of Amarex Clinical Research that managed CytoDyn's clinical trials.

Court documents say the two CEOs allegedly deceived investors about the status of CytoDyn's regulator submissions to the Food and Drug Administration to artificially inflate the price of CytoDyn's stock.

"The indictment alleges that these defendants conspired to defraud investors in order to line their own pockets," said U.S. Attorney Erek Barron for the District of Maryland.

"Investors must be able to rely on the statements of biotech companies about their products. Executives who knowingly mislead investors must be held accountable," Barron said.

In April 2020, court documents show CytoDyn and Amarex repeatedly missed publicized timelines. Pourhassan allegedly directed Amarex to submit the company's incomplete biologics license application so CytoDyn could announce to investors that the BLA had been submitted, even though both CEOs knew that the FDA would refuse the incomplete application.

In October, CytoDyn announced it was withdrawing the leronlimab BLA. Pourhassen was terminated in January.

"Financial crimes like securities fraud may not be violent, but they certainly are not victimless. The two individuals charged today capitalized on the hopes of investors and the public in supporting new treatments for ailments that affect people and their families," said Special Agent in Charge Thomas Sobocinski of the FBI Baltimore Field Office.

"This indictment sends a message to all sophisticated white-collar criminals that no one is beyond the reach of the FBI and our law enforcement partners and we do not tolerate the greedy intentions of those in such trusted positions."

The indictment also alleges that Pourhassan made false and misleading representations about CytoDyn's investigation and development of leronlimab as a possible treatment for COVID-19, despite clinical studies failing to achieve necessary results for FDA approval.

Pourhassan and Kazempour are each charged with one count of conspiracy to commit securities fraud and wire fraud, three counts of securities fraud and two counts of wire fraud related to the HIV BLA scheme.

Pourhassan is separately charged with an additional count of securities fraud, an additional count of wire fraud related to the COVID-19 scheme and three counts of insider trading. Kazempour is separately charged with one count of making false statements to federal law enforcement agents.

If convicted, both men face a maximum of 20 years in prison on each securities and wire fraud count, and five years for each conspiracy and false statements count.

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Most Free States 2022 – worldpopulationreview.com

Posted: at 10:30 pm

Fiscal policy includes state taxation, local taxation, government consumption and investment, government debt, and cash and security assets. Regulatory policy includes: land-use freedomn, labor market freedom, lawsuit freedom, occupational freedom, miscellanrous regulatory freedom, and cable and communications. Personal freedom includes incarceration and arrests, guns, gambling, marriage, education, alcohol, asset forfeiture, marijuana, tobacco, mala prohibita and civil liberties, travel freedom, and campaign finance.

Each state was scored on over 200 policies involving fiscal policy, regulatory policy, and personal freedom. Policies were weighted according to the estimated costs that government restrictions on freedom impose on their victims. Fiscal policy was weighted at 30.4%, regulatory policy at 34.0%, and personal freedom at 34.1% (percentages do not equal 100% because of rounding).

Based on the rankings, Florida is the freest state in the United States. Florida is ranked first for fiscal policy, 11th for personal freedom, and 22nd for regulatory policy. Florida is one of seven states that do not levy a state income tax. Floridas overall state-level tax collections are more than a standard deviation and a half below the national average.

New Hampshire is the second-most free state in the country. New Hampshire ranks second for fiscal policy, with the government taxing less than any other state but Alaska. New Hampshire also ranks fifth for personal freedom, with low incarceration rates and drug arrest rates.

Indiana ranks 10th for fiscal policy, 10th for personal freedom, and fifth for regulatory policy. Indiana has built itself as the freest state in the Great Lakes region by a wide margin. State taxes have fallen while government debt has also declined. Educational freedom is excellent in Indiana. Legal gambling is extensive, victimless crime arrests are low, alcohol freedom has improved consistently over the past few years.

Colorado takes the number four spot for the freest states. Colorado ranks eighth for fiscal policy and fourth for personal freedom. The state has led the way in recreational cannabis regulation and has above average legal gambling and run rights. Colorado is ranked first on the report for freedom from cronyism (the appointment of friends and associates to positions of authority without proper regard to their qualifications). When it comes to regulatory policy, however, Colorado does not perform as well and is ranked 25th.

Nevada ranks second for personal freedom. Nevada is number one for legal gambling and is the only state with legal prostitution (in certain jurisdictions). Incarceration in Nevada is about average and non-drug victimless crime arrests have fallen in recent years. While personal freedom is Nevadas strength it does perform as well for fiscal or regulatory policy, which it ranks 22nd and 17th for.

North Dakota is the sixth-most free state in the U.S., ranking fifth for fiscal policy, 29 for personal freedom, and 19 for regulatory policy. North Dakotas tax burned is about 4.5% of adjusted income. State debts have been paid down and financial assets have been built up. North Dakota falls behind for regulatory policies, although its policies are still good. Land use is lightly regulated, there is a right-to-work law, and there is no state-level minimum wage.

Tennessee has the third-freest regulatory policies in the U.S. and is ranked tenth for regulatory policy; however, it ranks 45 for personal freedom. Tennessee is one of seven states with no individual state income tax and both state and local taxes and state and local debt have decreased. Tennessee ranks poorly for personal freedom due to its criminal justice policies and an above-average incarceration rate.

Ranking just two spots under its northern neighbor is South Dakota. South Dakota sixth for fiscal policy, 37 for personal freedom, and eighth for regulatory policy. South Dakota has one of the lowest tax burdens in the country and state and local debt is well below the national average. While the states regulatory policies are well above average, its criminal justice policies are very strict. Incarceration is high as well as drug and other victimless crimes.

Arizona is the ninth-most free state in the United States. Arizona ranks 18th for fiscal policy, 14 for personal freedom, and 16 for regulatory policy. Arizona has made significant progress in the rankings in the last 20 years, specifically on personal freedom. This is due to growing gun rights, declining victimless crime arrests, legalization of same-sex marriage, the abolition of its sodomy law, and liberalizing its wine shipment laws.

Kansas takes the tenth spot on the freest states in the country and ranks first for regulatory policy. Kansas is one of the best states for freedom from cronyism, land-use freedom is high, and occupational freedom is high. Kansas does significantly worse for fiscal policy and personal freedom, ranking 32 and 21, respectively. Government employment and debt in South Dakota are higher than average. Additionally, while Kansas does relatively better than other conservative states when it comes to criminal justice, its incarceration rate has been slowly increasing over time.

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12 Best Casino Affiliate Programs of 2022 (Top Offers) – AuthorityHacker

Posted: at 10:29 pm

This roundup is going to shake things up a little bit because we look at some of the best casino affiliate programs out there.

And when we say casino, we mean in the online sense and not the Las Vegas hotel sense.

There are affiliates who treat the online gambling niche as being completely taboo. And there are affiliates who make ludicrous amounts of money promoting programs in this niche.

Which route you take is entirely up to you were just here to inform you.

Like the fact that this industry is going to be worth north of US$90 billion by 2024.

Or that many states in the US prohibit online gamblingbut there are ways around this.

And that theres one specific provision in some casino affiliate programs that you need to watch out for.

Intrigued?

You should be.

Youll have three choices when getting paid by these programs:

CPA = you get paid every time they visit the casino from your site

CPL = you get paid once for their registration

Revenue share = you get a percentage of what the player loses

Most programs only offer a revenue sharing payment model, which is fine on the surface of things. But you need to watch out for something called Negative Carryover.

With revenue share, when your player loses big you win big. If, however, they win big then you lose big. This leaves you with a negative balance on your affiliate account.

Some affiliate programs will wipe this negative balance clean at the end of the month but not all of them.

Always, always read the fine print, my friends.

Now, lets get to the programs themselves.

Multiple casino brands operate under the Betsson umbrella, including Betsafe, Casino and Star Casino. Theyve been in the casino game now for over 50 years, so youre dealing with an established brand.

Players can choose from dozens of classic slots and table games or a range of live casino games. One note here is that theyre focused on the European market, which means US players are out of luck.

Their affiliate program operates on a revenue share basis, and you can also get paid for signing up sub-affiliates.If you have plenty of skin in this niche, you can apply for their exclusive CPA program, where you get paid once for all new players/depositors.

URL: Betsson affiliate program

Commission: 20% 30% revenue share

Suitable for US Market: No

Negative carryover: No

Cookie duration: 30 days

BitStarz has earned a reputation for not only providing an enjoyable casino experience but a safe one too. Based on that and their top-notch customer service and live chat support, you can factor in that they get tons of positive reviews from players.

BitStarz is a mobile-friendly casino that offers slots and live games, and you can pay for many of these games with cryptocurrencies, but not all of them.

New players who deposit at least 20, 20, or $20 are entitled to a welcome package, which can include a 100% matching bonus for whatever amount you deposit.

So how well do they take care of their affiliates? You can earn up to a 40% revenue share, and theyre happy to have their offers promoted via email or Skype, so you dont even need a website.

URL: BitStarz affiliate program

Commission: Up to 40% revenue share

Suitable for US Market: Yes

Negative carryover: No

Cookie duration: 30 days

Even people who dont visit casino sites will have heard of Bet 365. Thats because theyre one of the worlds largest online casinos and one of the most popular.

US players are welcome, so thats one major box ticked in their favor.Along with all the usual slots and other casino games, Bet 365 offers roulette, blackjack, and baccarat via a video stream with a real dealer.

This site is also fully mobile, so youre not tied to a desktop or laptop and can enjoy your games on a smartphone or tablet.

Bet 365 usually garners pretty positive reviews, so theyre obviously doing something right.

Unlike the sliding scale offered by other casinos, affiliates get a flat 30% revenue share. In addition to this, Bet 365 also operates a negative carryover on affiliate accounts, so bear that in mind when signing up.

URL: Bet 365 affiliate program

Commission: 30% flat revenue share

Suitable for US Market: Yes

Negative carryover: Yes

Cookie duration: 45 days

Ace Revenue is a little different in that its not a casino in and of itself. Instead, its an umbrella affiliate program covering a number of online casinos such as Silver Oak, Captain Jack, Slot Madness, and Royal Ace, for example.

Players get to enjoy all the usual games such as slots, poker, video poker, and table games such as roulette.US players are also more than welcome on all of their partner sites.

What also sets Ace Revenue apart from its competitors is that they pay lifetime commissions.

Once signed up, you can start earning either a 35% or 45% revenue share, but they also offer a two-tier program so you can get paid up to 5% for your sub-affiliates.Ace Revenue is also happy to discuss tailored CPA offers for high-performing affiliates.

URL: Ace Revenue affiliate program

Commission: Up to 45% revenue share

Suitable for US Market: Yes

Negative carryover: No

Cookie duration: Lifetime

Casumo Casino stands out from the crowd because, unlike so many of its competitors, its site doesnt look like it traveled forward in time from 1998. In addition to the modern design and interface, you can enjoy a live casino experience with real dealers for your blackjack, Texas Holdem, roulette, and baccarat game. They also offer a wide selection of games from third parties like Microgaming, Bally Barcrest, Elk Studios, etc.

Casumo has an in-house game called Topwheel Treasures, where you spin the wheel for prizes like on game shows.

In terms of regular games, players get points for every game-related action they take, which they can then redeem for free spins, a bonus on their deposit, or some extra cash straight into their account.

As an affiliate partner, youll get a revenue share of between 25% and 45%, depending on how many players you sign up. The top tier revenue share of 45% is reserved for affiliates who can refer at least 50 new customers.

URL: Casumo Casino affiliate program

Commission: Up to 45% revenue share

Suitable for US Market: No

Negative carryover: No

Cookie duration: 30 days

Genesis Casino caught our attention because they make a genuine effort to add some excitement to what they do. They even do a little bit of content marketing storytelling on their site, which is novel. But theyre also not sitting there going, Yeah were hereso give us money.

What can players expect?

Genesis Casino offers 1,300 different games, including online slots, video poker, and all your usual favorites. They also offer a live casino experience, including several flavors of roulette. However, mobile gamers will have to use a browser because Genesis does not currently offer a dedicated app for their casino.

Most affiliates will earn their income from a revenue share of up to 35% and an additional 2.5% from sub-affiliates.Genesis Casino will consider CPA offers, but only for affiliates who can prove they know what to do with that.

URL: Genesis Casino affiliate program

Commission: Up to 35% revenue share

Suitable for US Market: No

Negative carryover: No

Cookie duration: 70 days

Cashmio is a relative newcomer to an industry where competitors boast about having decades of experience. This online casino signed its first customers in 2016. Still, the flip side of this is the Scandinavian entrepreneurs behind the curtains of Cashmio have a ton of experience in casino support.

So they decided to take what they knew and create the kind of casino theyd enjoy using. And what your visitors get is a site crammed full of games they love, including virtual casino games, live events, and all the usual online slot games.Players can also take their games mobile with the Cashmio app, available for both iOS and Android devices.

Whats in it for affiliates?

In terms of commission, you can earn anywhere from 25% 45% revenue share. Cashmio is also available in multiple languages, so your audience is larger by several hundred million players as a result.

URL: Cashmio affiliate program

Commission: Up to 45% revenue share

Suitable for US Market: No

Negative carryover: No

Cookie duration: 60 days

Using mascots is one way of building your brand, and Bao Casino has done a pretty good job of that. It gives their site a fun look and makes it memorable for players.

Inside the digital doors of this online casino, youll find a mixture of in-house live casino and table games, as youd expect. These are mixed with familiar virtual video slot offerings from NetEnt, Amatic, and Quickfire. And if you fancy playing a few hands of poker, you can do that here too.

They also run a range of crypto games, where you can participate without ever using regular currency, which hints at the future of online casino gaming.

Affiliates are paid differing amounts depending on whether you choose revenue share, their CPA option, or a hybrid program. One thing to watch out for is that you have to earn 4,000 in a given month before you can receive an affiliate payment.Thats pretty extreme unless youre a very active affiliate.

URL: Bao Casino affiliate program

Commission: Varies

Suitable for US Market: No

Negative carryover: No

Cookie duration: 30 days

Golden Star Casino was established in 2012 and is run by a team of seasoned casino players and others involved in the industry.Players can participate in the usual games of chance, including virtual slots with something for everyone. But you can also play table games or go for the live game experience.

You can choose from roulette, blackjack, and keno from their live casino games. Each of the live games has real dealers, so the experience can be pretty immersive.

Golden Star also supports Bitcoin games, so you dont actually need to use your regular bank account or credit card details. The site is also available in several languages and is mobile-friendly, so theres no dedicated app for it.

Affiliates are paid up to 50% revenue share, and theres no negative carryover. One final note on this program is that it is not available for the US market and is also not available for a UK audience.

URL: Golden Star affiliate program

Commission: Up to 50% revenue share

Suitable for US Market: Yes

Negative carryover: No

Cookie duration: 180 days

Cloudbet is a casino you can expect to see a lot more of in the future one that only trades in Bitcoin. Internet censorship seems to be ramping up, so I can see a time when part of going off-grid for some people will mean dumping FIAT currency.

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Complementary and alternative medicine – NHS

Posted: at 10:25 pm

Complementary and alternative medicine (CAM) is treatment that falls outside of mainstream healthcare.

These treatments range from acupuncture and homeopathy, to aromatherapy, meditation and colonic irrigation.

There's no universally agreed definition of CAM.

Although "complementary and alternative" is often used as a single category, it can be useful to make a distinction between the terms.

The US National Center for Complementary and Integrative Health (NCCIH) uses this distinction:

There can be overlap between these categories.

For example, aromatherapy may sometimes be used as a complementary treatment and in other circumstances is used as an alternative treatment.

A number of complementary and alternative treatments are typically used with the intention of treating or curing a health condition.

Examples include:

To understand whether a treatment is safe and effective, we need to check the evidence.

You can learn more about the evidence for particular CAM practices by reading about individual types of treatment.

See our Health A to Z index for a list of all conditions and treatments on the NHS website.

Some CAM treatments are based on principles and an evidence base that are not recognised by the majority of independent scientists.

Others have been proven to work for a limited number of health conditions.

For example, there's evidence that chiropractic is effective for treating lower back pain.

When a person uses any health treatment, including CAM, and experiences an improvement, this may be due to the placebo effect.

The availability of CAM on the NHS is limited, and in most cases the NHS will not offer such treatments.

The National Institute for Health and Care Excellence (NICE) provides guidance to the NHS on effective treatments that are value for money.

NICE has recommended the use of CAM in a limited number of circumstances.

For example:

If you think you may have a health condition, first see your GP. Do not visit a CAM practitioner instead of seeing your GP.

It's particularly important to talk to your GP before trying CAM if you have a pre-existing health condition or are pregnant.

Some CAM treatments may interact with medicines that you're taking or should not be tried if you're pregnant.

The practice of conventional medicine is regulated by laws that ensure that practitioners are properly qualified and adhere to certain standards or codes of practice. This is called statutory professional regulation.

Chiropractors are regulated in the same way. However, there's no statutory professional regulation of any other CAM practitioners.

Chiropractic is regulated in the same way as conventional medicine.

All chiropractors must be registered with the General Chiropractic Council. You can use the General Chiropractic Council website to find a registered chiropractor near you or check if someone offering chiropractic services is registered.

Apart from chiropractic, there's no professional statutory regulation of complementary and alternative treatments in the UK.

This means:

If you decide to use a CAM practitioner, it's up to you to find one who will carry out the treatment in a way that's acceptable to you. Professional bodies and voluntary registers can help you do this.

Some regulated healthcare professionals, such as GPs, also practise unregulated CAM.

In these instances, the CAM practice is not regulated by the organisation that regulates the healthcare professional (such as the General Medical Council), but these organisations will investigate complaints that relate to the professional conduct of their member.

Many types of CAM have voluntary registers, some of which are accredited by the Professional Standards Authority for Health and Social Care (PSA) or professional associations that practitioners can join if they choose.

Usually, these associations or registers demand that practitioners hold certain qualifications and agree to practise to a certain standard.

Organisations with PSA-accredited voluntary registers include:

This means that these organisations have met the PSA's demanding standards, which are designed to help people make an informed choice when they're looking for a practitioner.

Read about accredited registers on the Professional Standards Authority website

Once you have found a practitioner, it's a good idea to ask them some questions to help you decide if you want to go ahead with treatment.

You could ask:

Page last reviewed: 01 March 2022Next review due: 01 March 2025

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Alternative Treatment (CAM) for MS: Types, Side Effects & Cost

Posted: at 10:25 pm

Alternative treatment (CAM) for MS facts

Multiple sclerosis symptoms vary widely, and a description of "typical" symptoms is difficult. Some signs and symptoms of MS may include:

What is complementary or alternative treatment or CAM?

CAM (complementary and alternative medicine) is care provided in addition (integrative medicine) to or instead of traditional or standard medical practices. This group of therapies is wide-ranging and includes:

Some people who seek out alternative medicine feel that conventional therapy has not successfully controlled their symptoms, or that the potential side effects associated with traditional therapy aren't acceptable. Others find that adding complementary medicine to their program allows improved control of symptoms. When complementary medicine is added to traditional routes, it is referred to as integrative medicine.

Recent studies through the US Centers for Disease Control and Prevention (CDC), specifically the National Health Interview Survey, suggest that as many as 38% of residents within the United States seek out CAM.

Many therapies that are considered within the group of complementary and alternative medicines haven't been studied extensively or investigated in comparison to conventional treatment options.

What is of multiple sclerosis (MS)?

Multiple sclerosis (MS) is a disease that causes demyelination of the brain and spinal cord or a loss of the covering around axons. When this occurs, the axons (the parts of the nerve cells that transmit impulses to other cells) don't work well. As more areas of the central nervous system are affected by the loss of myelin, different symptoms develop.

What are the symptoms of MS?

The specific symptom seen in MS is related to the area of injury in the brain or spinal cord. Examples of symptoms of MS include:

What alternative treatments can be used for MS symptoms?

Fatigue and spasticity seem to respond best to CAM.

Therapies that have been shown to be of some benefit for fatigue have included:

Spasticity has reportedly been reduced with the use of acupuncture and massage therapy. A sense of tingling (paresthesias) has been reportedly improved with reflexology.

Symptoms including depression, memory loss, urinary incontinence, and progression of MS itself (including relapses, disease extent as measured on MRI), and disability have had limited improvement when treated with CAM.

Therapies tested in an effort to improve these symptoms have included:

None of these treatments led to any significant benefit in the studied symptoms.

What about medical marijuana (cannabis) for MS symptoms?

There have been a number of studies looking at the potential benefits of medical marijuana (cannabis) on MS symptoms, including spasticity and chronic pain. There is some suggestion that FDA-approved forms of medical cannabis (Marinol or Sativex) may be beneficial in improving spasticity or bladder frequency. However, there are no reports that ingested or inhaled medical marijuana is beneficial for conditions associated with MS.

The National Multiple Sclerosis Society has more information about medical marijuana for MS symptoms (http://www.nationalmssociety.org/Treating-MS/Complementary-Alternative-Medicines/Marijuana)

Who is eligible to pursue treatment with CAM?

Anyone can participate in CAM therapy. However, it is important to recognize that most of these therapies are not covered by insurance, and may be an "out of pocket" cost for patients with MS.

Patients who decide to pursue CAM need to share this information with their physicians, as some supplements may interact with conventional medication and lead to side effects.

How much does CAM cost?

The costs of CAM can vary widely; regular exercise and yoga can be low or no-cost options, while massage therapy, acupuncture, and some supplements can be quite expensive.

Every patient must have a good relationship with treating healthcare professionals of traditional and non-traditional therapies to best understand potential costs.

By clicking Submit, I agree to the MedicineNet's Terms & Conditions & Privacy Policy and understand that I may opt out of MedicineNet's subscriptions at any time.

What are the potential risks and side effects of CAM?

Side effects of CAM vary depending on the treatment.

It is important to discuss any potential or ongoing use of CAM with your healthcare professional, who may need to adjust your current therapies to prevent any adverse effects caused by interactions between the two types of therapies.

What different types of CAM were studied in the National Health Interview Survey?

Different types of complementary and alternative medicines that were studied in the National Health Interview Survey from 2002 through 2012 include:

Medically Reviewed on 10/26/2022

References

REFERENCES:

Clarke TC, Black LI, Stussman BJ, Barnes PM, Nahin, RL. Trends in the Use of Complementary Health Approaches Among Adults: United States, 2002-2012. National Health Statistics Reports. Number 79; February 10, 2015.

The National Multiple Sclerosis Society. MS Symptoms.

UpToDate. Patient information: Multiple sclerosis in adults (The Basics).

Yadav V, Bourdette D. Complementary and Alternative Medicine: Is There a Role in Multiple Sclerosis? Current Neurology and Neuroscience Reports 2006, 6:259267.

Yadav V, Bever C, Bowen J, et al. Summary of evidence-basaed guideline: Complementary and alternative medicine in multiple sclerosis. Report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology 2014;82;1083-1092.

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Complementary and alternative medicine | History & Facts

Posted: at 10:25 pm

complementary and alternative medicine (CAM), any of various approaches intended to improve or maintain human health that are not part of standard medical care, also known as conventional, or Western, medicine. The various approaches of CAM typically are used in a manner that is complementary to standard medical practices or are used in place of standard medicine. Such approaches are sometimes referred to as holistic or traditional medicine, although those areas of medicine do not cover all forms of CAM. Indeed, CAM includes not only classical systems, such as Ayurvedic medicine and traditional Chinese medicine, which are centred on bringing together the mind, body, and spirit, but also a wide range of other forms of therapy, including chiropractic medicine, biofeedback, art therapy, hypnosis, prayer, specialty diets, and therapeutic touch. Many of those practices are considered to be marginal when compared with conventional practicesthat is, they usually are not a central part of the medical curriculum, nor are they typically prescribed by physicians who practice conventional medicine. However, partly because of the growing evidence base that supports the safety and efficacy of certain CAM approaches, some practitioners of conventional medicine have also become practitioners of CAM.

Prior to the rise of scientific medicine in the 19th century, medical practice was a relatively undifferentiated field. Herbal remedies were prescribed regularly, and the range of practitioners on offer included not only the precursors of contemporary doctors but also groups such as bonesetters and healers. In some cultures those suffering from illness and disease were able to make use of what was a relatively strong cradle of neighbourliness and community support, where the human condition was viewed holistically. In other cultures, however, the sick and disabled were shunned, alienated, or neglected, largely because of a lack of knowledge of disease. With the rise of scientifically based medicine and the development of the modern medical profession, however, the understanding of human disease increased dramatically. Health care became increasingly centred on biomedicine, and a division of labour proliferated. Some doctors, for example, specialized in surgery, whereas others focused on areas such as infectious disease, human development, or mental health. In addition, beginning in the 19th century, scientists discovered ways to isolate and synthesize the active ingredients of plant-based medicines, which gave rise to the modern pharmaceutical industry. By the mid-20th century the advances in medicine had marginalized CAM in Western countries.

In the 1960s and 70s, however, a sort of medical counterculture arose in the West, born from the more general countercultural trend that involved, among other things, a rising interest in Eastern practices of meditation, mysticism, and other philosophies. There was a growing awareness of the limits of conventional medicine, and some believed that modern biomedicine was becoming increasingly counterproductive. Such perspectives were fueled in part by highly publicized medical tragedies, such as those involving thalidomide, which was withdrawn from the market in the early 1960s, and diethylstilbestrol, which was withdrawn in the 1970s; both agents were found to increase the risk of prenatal toxicity. Some people also associated conventional medicine with depersonalization and disempowerment of the patient. Consumers demanded increasing control over their own health, which led to the development of self-help and to the emergence of campaign groups that lobbied on behalf of health consumers and specific groups, such as the disabled and those afflicted by cancer and HIV/AIDS. In the wake of the counterculture, public interest in CAM gained new impetus.

The number of people in Europe and North America who use CAM is considerable. In the United States, for example, a 2007 survey revealed that about 38 percent of adults had used some form of CAM in the past year. A study published in 2010 indicated that about 26 percent of people in England had used CAM at some point in the year prior to filling out the studys survey.

The therapies employed and the extent of their use vary considerably by country. Although the majority of use involves self-help (e.g., use of over-the-counter herbs), a rise in the number of CAM practitioners enabled increasing numbers of people to seek the assistance of CAM providers. Growing numbers of conventional practitioners also employed CAM. In such cases, CAM therapies tend to be prescribed or administered for very specific and evidence-supported purposes, such as the use of acupuncture to relieve pain. As a result, in some cases, the use of CAM by conventional practitioners is not wholly in agreement with traditional principles. Acupuncture, for example, is viewed in traditional Chinese medicine as a panacea, being used to restore balance between the polar forces of yin and yang along meridians.

Reluctance among doctors to employ CAM often is related to the protection of their patients. Despite the ideology of a safe, natural approach to health care frequently espoused by CAM therapists, the approaches used in CAM pose certain hazards to users, ranging from punctured lungs in the case of acupuncture to potentially fatal overdosing from herbal remedies. There are also major gaps in the evidence that has been provided for such therapies. By the late 20th century many complementary and alternative therapies still had not been explored in clinical trials in human patients, unlike most drugs and devices employed in conventional medicine. That was largely because manufactured pharmaceuticals and other medical products were thought to be superior to complementary and alternative therapies, and so the latter did not attract significant investment from governments and biomedical companies. In the early 21st century, however, an increased need for medicines generally resulted in renewed interest in natural-products drug discovery and in unorthodox medical practices, which in turn led to a rise in the clinical exploration of various CAM therapies.

Much debate remains about how to assess the efficacy of CAM. The need for large-scale randomized controlled trials is highly controversial, particularly because many complementary and alternative therapies have been used by humans for centuries and because certain conventional medicines that have been scrutinized by such means have later been discovered to cause severe side effects, resulting in their removal from the market. There are also significant methodological questions about whether the randomized controlled trial is the best way to evaluate complementary and alternative therapies, especially when they are employed holistically. Many treatments associated with CAM are targeted toward individuals, rather than toward conditions (e.g., diabetes or heart failure) as in conventional medicine, suggesting that alternative methods of assessment may be more appropriate. For example, randomized controlled trial methodology attempts to eliminate the placebo effect, but some researchers have claimed that the placebo effect should be more fully employed in studies of complementary and alternative therapies. Other methods, such as case studies and consumer-satisfaction surveys, are attractive evaluative tools for CAM.

Many small-scale controlled trials of CAM have been conducted, with comparisons to placebos and to conventional approaches. Some of those trials have produced encouraging resultsfor example, the use of acupuncture in the relief of chronic pain. However, from the standpoint of conventional research methodologies, the numbers of participants usually has been too restricted to make firm judgments about the likely efficacy of particular complementary and alternative therapies. In such cases, systematic reviews of trial data can be helpful, provided that clear criteria to assess the quality of the studies are employed and that there is a sufficient number of credible trials on which to build the meta-analysis. In the field of herbal medicine, such systematic reviews have suggested that extracts of St. Johns wort (Hypericum perforatum) can provide symptomatic relief in cases of mild to moderate depression and that peppermint oil is more effective than a placebo for the treatment of irritable bowel disease.

Beyond evidence from randomized controlled trials, the data set on CAM is enriched by a plethora of individual case studies, many of which indicate the positive qualitative outcomes that can be obtained from such therapies. The use of CAM also tends to produce high levels of consumer satisfaction. The subjective views elicited in such research, however, must be weighed against a variety of methodological pitfalls in interpreting such results. Nonetheless, data from case studies and consumer surveys have indicated that unorthodox therapies could help to fill the vacuum created in areas where conventional medicine has little to offer. Case studies and surveys have also emphasized the fact that the many diverse approaches of CAM vary in their effectiveness and use. In the United Kingdom, for example, research has suggested that therapies such as herbalism, homeopathy, and osteopathy tend to be relatively more effective for users than approaches based on crystal therapy, iridology, and radionics. Such variations in evidence for specific forms of CAM have necessitated careful and critical scrutiny of claims about curative or palliative powers.

Even where it is felt that CAM can benefit patients, major challenges remain. For example, complementary and alternative therapies may not be accessible to consumers within state-financed health provision and insurance programs. Furthermore, complementary and alternative therapies are not inexpensive versions of conventional medicines or practices. Some CAM approaches can, in fact, be quite costly, particularly when repeat visits are made to a practitioner. Thus, patients cannot turn to CAM to save on health care costs.

Another issue concerns the extent to which CAM is regulated in terms of protecting the interests of health consumers. The remedies themselves, as well as CAM practitioners, have been increasingly subject to regulation, but the parameters of regulation are not always well balanced. For instance, despite growing trends toward professionalization, the practice of CAM in some countries may be exclusively concentrated among certain doctors, medical groups, or allied health professionals. In other countries, CAM is loosely assigned to anyone who wishes to be engaged in the field, with CAM systems largely based on voluntary regulatory arrangements to which not all practitioners are legally bound.

Finally, CAM does not simply challenge biomedicine in terms of best practice. In its most radical forms, it also challenges some of the assumptions underpinning medical orthodoxy and questions the medical concept of disability. Many of those currently involved in practicing CAM, for example, no longer see consumers in medicalized terms as patients. Rather, individuals are seen as actively participating in their own well-being. Given its links to the counterculture, the self-help aspect of CAM therefore may not be viewed simply as an appendage to medicine. Some see it instead as challenging the power of the medical profession. Scientifically based medicine remains dominant, but the approaches that are categorized as CAM are expected to become more fully integrated into conventional medicine, which ultimately could give rise to a new medical orthodoxy.

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fiscal federalism | public finance | Britannica

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fiscal federalism, financial relations between units of governments in a federal government system. Fiscal federalism is part of broader public finance discipline. The term was introduced by the German-born American economist Richard Musgrave in 1959. Fiscal federalism deals with the division of governmental functions and financial relations among levels of government.

The theory of fiscal federalism assumes that a federal system of government can be efficient and effective at solving problems governments face today, such as just distribution of income, efficient and effective allocation of resources, and economic stability. Economic stability and just distribution of income can be done by federal government because of its flexibility in dealing with these problems. Because states and localities are not equal in their income, federal government intervention is needed. Allocation of resources can be done effectively by states and local governments. Musgrave argued that the federal or central government should be responsible for the economic stabilization and income redistribution but the allocation of resources should be the responsibility of state and local governments.

The following are benefits of fiscal decentralization: regional and local differences can be taken into account; lower planning and administrative costs; competition among local governments favours organizational and political innovations; and more efficient politics as citizens have more influence. There are several disadvantages of fiscal federalism as well: the lack of accountability of state and local governments to constituents; the lack of availability of qualified staff; the possibility for people to choose where to reside; a certain degree of independence of the local governments from the national government; and unavailability of infrastructure of public expenditure at the local level.

Fiscal federalism is affected by the relationship between levels of government and thus by the historical events that shape this relationship. For instance, in the early years of American federalism, geographic separation, slow communication, and clear division of labour made it possible for each level of government to function without significant interactions with other levels. Several developments resulted in more interactions and central planning among the levels of government: improvement in transportation and communication technologies; the New Deal of the 1930s; the World Wars and the Cold War; and the war against poverty from the 1960s. These developments increased the interactions among levels of government and helped the development of national policy making and state and local policy implementation. It also changed traditional intergovernmental relations. National fiscal policies and financial decisions have been the predominant vehicle forming intergovernmental relations. Fiscal federalism operates through the various federal taxes, grants, and transfers that occur in addition to states and localities. The federal government regulates, subsidizes, taxes, provides goods and services, and redistributes income. In federal systems like that of the United States, fiscal policies have also sought to empower the states through deregulation.

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Trump, Brexit, and the Rise of Populism: Economic Have-Nots and …

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Abstract

Rising support for populist parties has disrupted the politics of many Western societies. What explains this phenomenon? Two theories are examined here. Perhaps the most widely-held view of mass support for populism -- the economic insecurity perspective--emphasizes the consequences of profound changes transforming the workforce and society in post-industrial economies. Alternatively, the cultural backlash thesis suggests that support can be explained as a reaction against cultural changes that threaten the worldview of once-predominant sectors of the population. To consider these arguments, Part I develops the conceptual and theoretical framework. Part II of the study uses the 2014 Chapel Hill Expert Survey (CHES) to identify the ideological location of 268 political parties in 31 European countries. Part III compares the pattern of European party competition at national-level. Part IV uses the pooled European Social Survey 1-6 (2002-2014) to examine the cross-national evidence at individual level for the impact of the economic insecurity and cultural values as predictors of voting for populist parties. Part V summarizes the key findings and considers their implications. Overall, we find consistent evidence supporting the cultural backlash thesis.

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The Physics of DNA: In Each of Us Lies a Message, Its Beginnings Lost in the Mists of Time – The Daily Galaxy –Great Discoveries Channel

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The Physics of DNA: In Each of Us Lies a Message, Its Beginnings Lost in the Mists of Time  The Daily Galaxy --Great Discoveries Channel

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The Physics of DNA: In Each of Us Lies a Message, Its Beginnings Lost in the Mists of Time - The Daily Galaxy --Great Discoveries Channel

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