Daily Archives: November 25, 2022

Ted Williams – Wikipedia

Posted: November 25, 2022 at 5:18 am

American baseball player (19182002)

Baseball player

Williams in 1949

As manager

Theodore Samuel Williams (August 30, 1918 July 5, 2002) was an American professional baseball player and manager. He played his entire 19-year Major League Baseball (MLB) career, primarily as a left fielder, for the Boston Red Sox from 1939 to 1960; his career was interrupted by military service during World War II and the Korean War. Nicknamed "Teddy Ballgame", "the Kid", "the Splendid Splinter", and "The Thumper", Williams is regarded as one of the greatest hitters in baseball history and to date is the last player to hit over .400 in a season.

Williams was a nineteen-time All-Star,[1] a two-time recipient of the American League (AL) Most Valuable Player Award, a six-time AL batting champion, and a two-time Triple Crown winner. He finished his playing career with a .344 batting average, 521 home runs, and a .482 on-base percentage, the highest of all time. His career batting average is the highest of any MLB player whose career was played primarily in the live-ball era, and ranks tied for 7th all-time (with Billy Hamilton).

Born and raised in San Diego, Williams played baseball throughout his youth. After joining the Red Sox in 1939, he immediately emerged as one of the sport's best hitters. In 1941, Williams posted a .406 batting average; he is the last MLB player to bat over .400 in a season. He followed this up by winning his first Triple Crown in 1942. Williams was required to interrupt his baseball career in 1943 to serve three years in the United States Navy and Marine Corps during World War II. Upon returning to MLB in 1946, Williams won his first AL MVP Award and played in his only World Series. In 1947, he won his second Triple Crown. Williams was returned to active military duty for portions of the 1952 and 1953 seasons to serve as a Marine combat aviator in the Korean War. In 1957 and 1958 at the ages of 39 and 40, respectively, he was the AL batting champion for the fifth and sixth time.

Williams retired from playing in 1960. He was inducted into the Baseball Hall of Fame in 1966, in his first year of eligibility.[2] Williams managed the Washington Senators/Texas Rangers franchise from 1969 to 1972. An avid sport fisherman, he hosted a television program about fishing, and was inducted into the IGFA Fishing Hall of Fame.[3] Williams's involvement in the Jimmy Fund helped raise millions in dollars for cancer care and research. In 1991, President George H. W. Bush presented Williams with the Presidential Medal of Freedom, the highest civilian award bestowed by the United States government. He was selected for the Major League Baseball All-Time Team in 1997 and the Major League Baseball All-Century Team in 1999.

Williams was born in San Diego on August 30, 1918,[4] and named Theodore Samuel Williams after former president Theodore Roosevelt as well as his father, Samuel Stuart Williams.[5] He later amended his birth certificate, removing his middle name,[5] which he claimed originated from a maternal uncle (whose actual name was Daniel Venzor), who had been killed in World War I.[6] His father was a soldier, sheriff, and photographer from Ardsley, New York,[7] while his mother, May Venzor, a Spanish-Mexican-American from El Paso, Texas, was an evangelist and lifelong soldier in the Salvation Army.[5] Williams resented his mother's long hours working in the Salvation Army,[8] and Williams and his brother cringed when she took them to the Army's street-corner revivals.[9]

Williams's paternal ancestors were a mix of Welsh, English, and Irish. The maternal, Spanish-Mexican side of Williams's family was quite diverse, having Spanish (Basque), Russian, and American Indian roots.[10] Of his Mexican ancestry he said that "If I had my mother's name, there is no doubt I would have run into problems in those days, [considering] the prejudices people had in Southern California."[11]

Williams lived in San Diego's North Park neighborhood (4121 Utah Street).[12] At the age of eight, he was taught how to throw a baseball by his uncle, Saul Venzor. Saul was one of his mother's four brothers, as well as a former semi-professional baseball player who had pitched against Babe Ruth, Lou Gehrig, and Joe Gordon in an exhibition game.[13][14] As a child, Williams's heroes were Pepper Martin of the St. Louis Cardinals and Bill Terry of the New York Giants.[15] Williams graduated from Herbert Hoover High School in San Diego, where he played baseball as a pitcher and was the star of the team.[16] During this time, he also played American Legion Baseball, later being named the 1960 American Legion Baseball Graduate of the Year.[17]

Though he had offers from the St. Louis Cardinals and the New York Yankees while he was still in high school,[18] his mother thought he was too young to leave home, so he signed up with the local minor league club, the San Diego Padres.[19]

Throughout his career, Williams stated his goal was to have people point to him and remark, "There goes Ted Williams, the greatest hitter who ever lived."[20]

Williams played back-up behind Vince DiMaggio and Ivey Shiver on the (then) Pacific Coast League's San Diego Padres. While in the Pacific Coast League in 1936, Williams met future teammates and friends Dom DiMaggio and Bobby Doerr, who were on the Pacific Coast League's San Francisco Seals.[21] When Shiver announced he was quitting to become a high school football coach in Savannah, Georgia, the job, by default, was open for Williams.[22] Williams posted a .271 batting average on 107 at bats in 42 games for the Padres in 1936.[22] Unknown to Williams, he had caught the eye of the Boston Red Sox's general manager, Eddie Collins, while Collins was scouting Bobby Doerr and the shortstop George Myatt in August 1936.[22][23] Collins later explained, "It wasn't hard to find Ted Williams. He stood out like a brown cow in a field of white cows."[22] In the 1937 season, after graduating from Hoover High in the winter, Williams finally broke into the line-up on June 22, when he hit an inside-the-park home run to help the Padres win 32. The Padres ended up winning the PCL title, while Williams ended up hitting .291 with 23 home runs.[22] Meanwhile, Collins kept in touch with Padres general manager Bill Lane, calling him two times throughout the season. In December 1937, during the winter meetings, the deal was made between Lane and Collins, sending Williams to the Boston Red Sox and giving Lane $35,000 and two major leaguers, Dom D'Allessandro and Al Niemiec, and two other minor leaguers.[24][25]

In 1938, the 19-year-old Williams was 10 days late to spring training camp in Sarasota, Florida, because of a flood in California that blocked the railroads. Williams had to borrow $200 from a bank to make the trip from San Diego to Sarasota.[26] Also during spring training Williams was nicknamed "the Kid" by Red Sox equipment manager Johnny Orlando, who after Williams arrived to Sarasota for the first time, said, "'The Kid' has arrived". Orlando still called Williams "the Kid" 20 years later,[26] and the nickname stuck with Williams the rest of his life.[27] Williams remained in major league spring training for about a week.[26] Williams was then sent to the Double-A-league Minneapolis Millers.[28] While in the Millers training camp for the springtime, Williams met Rogers Hornsby, who had hit over .400 three times, including a .424 average in 1924.[29] Hornsby, who was a coach for the Millers that spring,[29] gave Williams useful advice, including how to "get a good pitch to hit".[28] Talking with the game's greats would become a pattern for Williams, who also talked with Hugh Duffy, who hit .438 in 1894, Bill Terry who hit .401 in 1930, and Ty Cobb with whom he would argue that a batter should hit up on the ball, opposed to Cobb's view that a batter should hit down on the ball.[30]

While in Minnesota, Williams quickly became the team's star.[31] He collected his first hit in the Millers' first game of the season, as well as his first and second home runs during his third game. Both were inside-the-park home runs, with the second traveling an estimated 500 feet (150m) on the fly to a 512-foot (156m) center field fence.[31] Williams later had a 22 game hitting streak that lasted from Memorial Day through mid-June.[31] While the Millers ended up sixth place in an eight-team race,[31] Williams ended up hitting .366 with 46 home runs and 142 RBIs. He received the American Association's Triple Crown and finished second in the voting for Most Valuable Player.[32]

Williams came to spring training three days late in 1939, thanks to Williams driving from California to Florida, as well as respiratory problems, the latter of which would plague Williams for the rest of his career.[33] In the winter, the Red Sox traded right fielder Ben Chapman to the Cleveland Indians to make room for Williams on the roster, even though Chapman had hit .340 in the previous season.[34][35] This led Boston Globe sports journalist Gerry Moore to quip, "Not since Joe DiMaggio broke in with the Yankees by "five for five" in St. Petersburg in 1936 has any baseball rookie received the nationwide publicity that has been accorded this spring to Theodore Francis [sic] Williams".[33] Williams inherited Chapman's number 9 on his uniform as opposed to Williams's number 5 in the previous spring training. He made his major league debut against the New York Yankees on April 20,[36] going 1-for-4 against Yankee pitcher Red Ruffing. This was the only game which featured both Williams and Lou Gehrig playing against one another.[37] In his first series at Fenway Park, Williams hit a double, a home run, and a triple, the first two against Cotton Pippen, who gave Williams his first strikeout as a professional while Williams had been in San Diego.[38] By July, Williams was hitting just .280, but leading the league in RBIs.[38] Johnny Orlando, now Williams's friend, then gave Williams a quick pep talk, telling Williams that he should hit .335 with 35 home runs and he would drive in 150 runs. Williams said he would buy Orlando a Cadillac if this all came true.[39] Williams ended up hitting .327 with 31 home runs and 145 RBIs,[36] leading the league in the latter category, the first rookie to lead the league in RBIs[40] and finishing fourth in MVP voting.[41] He also led the AL in walks, with 107, a rookie record. Even though there was not a Rookie of the Year award yet in 1939, Babe Ruth declared Williams to be the Rookie of the Year, which Williams later said was "good enough for me".[42]

Williams's pay doubled in 1940, going from $5,000 to $10,000.[43] With the addition of a new bullpen in right field of Fenway Park, which reduced the distance from home plate from 400 feet to 380 feet, the bullpen was nicknamed "Williamsburg", because the new addition was "obviously designed for Williams".[44] Williams was then switched from right field to left field, as there would be less sun in his eyes, and it would give Dom DiMaggio a chance to play. Finally, Williams was flip-flopped in the order with the great slugger Jimmie Foxx, with the idea that Williams would get more pitches to hit.[44] Pitchers, though, were not afraid to walk him to get to the 33-year-old Foxx, and after that the 34-year-old Joe Cronin, the player-manager.[45] Williams also made his first of 16 All-Star Game appearances[46] in 1940, going 0-for-2.[47] Although Williams hit .344, his power and runs batted in were down from the previous season, with 23 home runs and 113 RBIs.[36] Williams also caused a controversy in mid-August when he called his salary "peanuts", along with saying he hated the city of Boston and reporters, leading reporters to lash back at him, saying that he should be traded.[48] Williams said that the "only real fun" he had in 1940 was being able to pitch once on August 24, when he pitched the last two innings in a 121 loss to the Detroit Tigers, allowing one earned run on three hits, while striking out one batter, Rudy York.[49][50]

In the second week of spring training in 1941, Williams broke a bone in his right ankle, limiting him to pinch hitting for the first two weeks of the season.[51] Bobby Doerr later claimed that the injury would be the foundation of Williams's season, as it forced him to put less pressure on his right foot for the rest of the season.[52] Against the Chicago White Sox on May 7, in extra innings, Williams told the Red Sox pitcher, Charlie Wagner, to hold the White Sox, since he was going to hit a home run. In the 11th inning, Williams's prediction came true, as he hit a big blast to help the Red Sox win. The home run is still considered to be the longest home run ever hit in the old Comiskey Park, some saying that it went 600 feet (180m).[53] Williams's average slowly climbed in the first half of May, and on May 15, he started a 22-game hitting streak. From May 17 to June 1, Williams batted .536, with his season average going above .400 on May 25 and then continuing up to .430.[54] By the All-Star break, Williams was hitting .406 with 62 RBIs and 16 home runs.[55]

In the 1941 All-Star Game, Williams batted fourth behind Joe DiMaggio, who was in the midst of his record-breaking hitting streak, having hit safely in 48 consecutive games.[56] In the fourth inning Williams doubled to drive in a run.[57] With the National League (NL) leading 52 in the eighth inning, Williams struck out in the middle of an American League (AL) rally.[56] In the ninth inning the AL still trailed 53; Ken Keltner and Joe Gordon singled, and Cecil Travis walked to load the bases.[57] DiMaggio grounded to the infield and Billy Herman, attempting to complete a double play, threw wide of first base, allowing Keltner to score.[57] With the score 54 and runners on first and third, Williams homered with his eyes closed to secure a 75 AL win.[57][58] Williams later said that that game-winning home run "remains to this day the most thrilling hit of my life".[59]

In late August, Williams was hitting .402.[59] Williams said that "just about everybody was rooting for me" to hit .400 in the season, including Yankee fans, who gave pitcher Lefty Gomez a "hell of a boo" after walking Williams with the bases loaded after Williams had gotten three straight hits one game in September.[60] In mid-September, Williams was hitting .413, but dropped a point a game from then on.[59] Before the final two games on September 28, a doubleheader against the Philadelphia Athletics, he was batting .39955, which would have been officially rounded up to .400.[59] Red Sox manager Joe Cronin offered him the chance to sit out the final day, but he declined. "If I'm going to be a .400 hitter", he said at the time, "I want more than my toenails on the line."[61] Williams went 6-for-8 on the day, finishing the season at .406.[62] (Sacrifice flies were counted as at-bats in 1941; under today's rules, Williams would have hit between .411 and .419, based on contemporaneous game accounts.[61]) Philadelphia fans ran out on the field to surround Williams after the game, forcing him to protect his hat from being stolen; he was helped into the clubhouse by his teammates.[63] Along with his .406 average, Williams also hit 37 home runs and batted in 120 runs, missing the triple crown by five RBI.[36][61]

Williams's 1941 season is often considered to be the best offensive season of all time, though the MVP award would go to DiMaggio. The .406 batting averagehis first of six batting championshipsis still the highest single-season average in Red Sox history and the highest batting average in the major leagues since 1924, and the last time any major league player has hit over .400 for a season after averaging at least 3.1 plate appearances per game. ("If I had known hitting .400 was going to be such a big deal", he quipped in 1991, "I would have done it again."[61]) Williams's on-base percentage of .553 and slugging percentage of .735 that season are both also the highest single-season averages in Red Sox history. The .553 OBP stood as a major league record until it was broken by Barry Bonds in 2002 and his .735 slugging percentage was the highest mark in the major leagues between 1932 and 1994. His OPS of 1.287 that year, a Red Sox record, was the highest in the major leagues between 1923 and 2001. Despite playing in only 143 games that year, Williams led the league with 135 runs scored and 37 home runs, and he finished third with 335 total bases, the most home runs, runs scored, and total bases by a Red Sox player since Jimmie Foxx's in 1938.[64] Williams placed second in MVP voting; DiMaggio won, 291 votes to 254,[65] on the strength of his record-breaking 56-game hitting streak and league-leading 125 RBI.[62]

In January 1942, just over 2 years after World War II began,[66][67] Williams was drafted into the military, being put into Class 1-A. A friend of Williams suggested that Williams see the advisor of the governor's Selective Service Appeal Agent, since Williams was the sole support of his mother, arguing that Williams should not have been placed in Class 1-A, and said Williams should be reclassified to Class 3-A.[66] Williams was reclassified to 3-A ten days later.[68] Afterwards, the public reaction was extremely negative,[69] even though the baseball book Season of '42 states only four All-Stars and one first-line pitcher entered military service during the 1942 season. (Many more MLB players would enter service during the 1943 season.)[70]

Quaker Oats stopped sponsoring Williams, and Williams, who previously had eaten Quaker products "all the time", never "[ate] one since" the company stopped sponsoring him.[68]

Despite the trouble with the draft board, Williams had a new salary of $30,000 in 1942.[68] In the season, Williams won the Triple Crown,[62] with a .356 batting average, 36 home runs, and 137 RBIs.[36] On May 21, Williams also hit his 100th career home run.[71] He was the third Red Sox player to hit 100 home runs with the team, following his teammates Jimmie Foxx and Joe Cronin.[citation needed] Despite winning the Triple Crown, Williams came in second in the MVP voting, losing to Joe Gordon of the Yankees. Williams felt that he should have gotten a "little more consideration" because of winning the Triple Crown, and he thought that "the reason I didn't get more consideration was because of the trouble I had with the draft [boards]".[62]

Williams joined the Navy Reserve on May 22, 1942, went on active duty in 1943, and was commissioned a second lieutenant in the United States Marine Corps as a Naval Aviator on May 2, 1944. Williams also played on the baseball team in Chapel Hill, North Carolina, along with his Red Sox teammate Johnny Pesky in pre-flight training, after eight weeks in Amherst, Massachusetts, and the Civilian Pilot Training Course.[72] While on the baseball team, Williams was sent back to Fenway Park on July 12, 1943, to play on an All-Star team managed by Babe Ruth. The newspapers reported that Babe Ruth said when finally meeting Williams, "Hiya, kid. You remind me a lot of myself. I love to hit. You're one of the most natural ballplayers I've ever seen. And if my record is broken, I hope you're the one to do it".[73] Williams later said he was "flabbergasted" by the incident, as "after all, it was Babe Ruth".[73] In the game, Williams hit a 425-foot home run to help give the American League All-Stars a 98 win.[74]

On September 2, 1945, when the war ended, Lt. Williams was in Pearl Harbor, Hawaii awaiting orders as a replacement pilot. While in Pearl Harbor, Williams played baseball in the Navy League. Also in that eight-team league were Joe DiMaggio, Joe Gordon, and Stan Musial. The Service World Series with the Army versus the Navy attracted crowds of 40,000 for each game. The players said it was even better than the actual World Series being played between the Detroit Tigers and Chicago Cubs that year.[75]

Williams was discharged by the Marine Corps on January 28, 1946, in time to begin preparations for the upcoming pro baseball season.[76][77] He joined the Red Sox again in 1946, signing a $37,500 contract.[78] On July 14, after Williams hit three home runs and eight RBIs in the first game of a doubleheader, Lou Boudreau, inspired by Williams's consistent pull hitting to right field, created what would later be known as the Boudreau shift (also Williams shift) against Williams, having only one player on the left side of second base (the left fielder). Ignoring the shift, Williams walked twice, doubled, and grounded out to the shortstop, who was positioned in between first and second base.[79][80] Also during 1946, the All-Star Game was held in Fenway Park. In the game, Williams homered in the fourth inning against Kirby Higbe, singled in a run in the fifth inning, singled in the seventh inning, and hit a three-run home run against Rip Sewell's "eephus pitch" in the eighth inning[81] to help the American League win 120.[82]

For the 1946 season, Williams hit .342 with 38 home runs and 123 RBIs,[36] helping the Red Sox win the pennant on September 13. During the season, Williams hit the only inside-the-park home run in his Major League career in a September 10 win at Cleveland,[83][84] and in June hit what is considered the longest home run in Fenway Park history, at 502 feet (153m) and subsequently marked with a lone red seat in the Fenway bleachers.[85] Williams ran away as the winner in the MVP voting.[86] During an exhibition game in Fenway Park against an All-Star team during early October, Williams was hit on the elbow by a curveball by the Washington Senators' pitcher Mickey Haefner. Williams was immediately taken out of the game, and X-rays of his arm showed no damage, but his arm was "swelled up like a boiled egg", according to Williams.[87] Williams could not swing a bat again until four days later, one day before the World Series, when he reported the arm as "sore".[87] During the series, Williams batted .200, going 5-for-25 with no home runs and just one RBI. The Red Sox lost in seven games,[88] with Williams going 0-for-4 in the last game.[89] Fifty years later when asked what one thing he would have done different in his life, Williams replied, "I'd have done better in the '46 World Series. God, I would".[87] The 1946 World Series was the only World Series Williams ever appeared in.[90]

Williams signed a $70,000 contract in 1947.[91] Williams was also almost traded for Joe DiMaggio in 1947. In late April, Red Sox owner Tom Yawkey and Yankees owner Dan Topping agreed to swap the players, but a day later canceled the deal when Yawkey requested that Yogi Berra come with DiMaggio.[92] In May, Williams was hitting .337.[93] Williams won the Triple Crown in 1947, but lost the MVP award to Joe DiMaggio, 202 points to 201 points. One writer left Williams off his ballot. Williams thought it was Mel Webb, whom Williams called a "grouchy old guy",[94] although it now appears it was not Webb.[95]

Through 2011, Williams was one of seven major league players to have had at least four 30-home run and 100-RBI seasons in their first five years, along with Chuck Klein, Joe DiMaggio, Ralph Kiner, Mark Teixeira, Albert Pujols, and Ryan Braun.[96]

In 1948, under their new manager, Joe McCarthy,[97] Williams hit a league-leading .369 with 25 home runs and 127 RBIs,[36] and was third in MVP voting.[98] On April 29, Williams hit his 200th career home run. He became just the second player to hit 200 home runs in a Red Sox uniform, joining his former teammate Jimmie Foxx.[64] On October 2, against the Yankees, Williams hit his 222nd career home run, tying Foxx for the Red Sox all-time record.[99] In the Red Sox' final two games of the regular schedule, they beat the Yankees (to force a one-game playoff against the Cleveland Indians) and Williams got on base eight times out of ten plate appearances.[97] In the playoff, Williams went 1-for-4,[100] with the Red Sox losing 83.

In 1949, Williams received a new salary of $100,000 ($1,139,000 in current dollar terms).[101] He hit .343 (losing the AL batting title by just .0002 to the Tigers' George Kell, thus missing the Triple Crown that year), hitting 43 home runs, his career high, and driving in 159 runs, tied for highest in the league, and at one point, he got on base in 84 straight games, an MLB record that still stands today, helping him win the MVP trophy.[36][102] On April 28, Williams hit his 223rd career home run, breaking the record for most home runs in a Red Sox uniform, passing Jimmie Foxx.[103] Williams is still the Red Sox career home run leader.[64] However, despite being ahead of the Yankees by one game just beforea 2-game series against them (last regular-season games for both teams),[97] the Red Sox lost both of those games.[104] The Yankees won the first of what would be five straight World Series titles in 1949.[105] For the rest of Williams's career, the Yankees won nine pennants and six World Series titles, while the Red Sox never finished better than third place.[105]

In 1950, Williams was playing in his eighth All-Star Game. In the first inning, Williams caught a line drive by Ralph Kiner, slamming into the Comiskey Park scoreboard and breaking his left arm.[46] Williams played the rest of the game, and he even singled in a run to give the American League the lead in the fifth inning, but by that time Williams's arm was a "balloon" and he was in great pain, so he left the game.[106] Both of the doctors who X-rayed Williams held little hope for a full recovery. The doctors operated on Williams for two hours.[107] When Williams took his cast off, he could only extend the arm to within four inches of his right arm.[108] Williams only played 89 games in 1950.[36] After the baseball season, Williams's elbow hurt so much he considered retirement, since he thought he would never be able to hit again. Tom Yawkey, the Red Sox owner, then sent Jack Fadden to Williams's Florida home to talk to Williams. Williams later thanked Fadden for saving his career.[109]

In 1951, Williams "struggled" to hit .318, with his elbow still hurting.[110] Williams also played in 148 games, 60 more than Williams had played the previous season, 30 home runs, two more than he had hit in 1950, and 126 RBIs, twenty-nine more than 1950.[36][110] Despite his lower-than-usual production at bat, Williams made the All-Star team.[47] On May 15, 1951, Williams became the 11th player in major league history to hit 300 career home runs. On May 21, Williams passed Chuck Klein for 10th place, on May 25 Williams passed Hornsby for ninth place, and on July 5 Williams passed Al Simmons for eighth place all-time in career home runs.[111] After the season, manager Steve O'Neill was fired, with Lou Boudreau replacing him. Boudreau's first announcement as manager was that all Red Sox players were "expendable", including Williams.[110]

Williams's name was called from a list of inactive reserves to serve on active duty in the Korean War on January 9, 1952. Williams, who was livid at his recalling, had a physical scheduled for April 2.[112] Williams passed his physical and in May, after only playing in six major league games, began refresher flight training and qualification prior to service in Korea. Right before he left for Korea, the Red Sox had a "Ted Williams Day" in Fenway Park. Friends of Williams gave him a Cadillac, and the Red Sox gave Williams a memory book that was signed by 400,000 fans. The governor of Massachusetts and mayor of Boston were there, along with a Korean War veteran named Frederick Wolf who used a wheelchair for mobility.[113] At the end of the ceremony, everyone in the park held hands and sang "Auld Lang Syne" to Williams, a moment which he later said "moved me quite a bit."[114] Private Wolf (an injured Korean veteran from Brooklyn) presented gifts from wounded veterans to Ted Williams. Ted choked and was only able to say,"... ok kid...".[115] The Red Sox went on to win the game 53, thanks to a two-run home run by Williams in the seventh inning.[114]

In August 1953, Williams practiced with the Red Sox for ten days before playing in his first game, garnering a large ovation from the crowd and hitting a home run in the eighth inning.[116] In the season, Williams ended up hitting .407 with 13 home runs and 34 RBIs in 37 games and 110 at bats (not nearly enough plate appearances to qualify for that season's batting title).[36] On September 6, Williams hit his 332nd career home run, passing Hank Greenberg for seventh all-time.[117]

On the first day of spring training in 1954, Williams broke his collarbone running after a line drive.[116] Williams was out for six weeks, and in April he wrote an article with Joe Reichler of the Saturday Evening Post saying that he intended to retire at the end of the season.[118] Williams returned to the Red Sox lineup on May 7, and he hit .345 with 386 at bats in 117 games, although Bobby vila, who had hit .341, won the batting championship. This was because it was required then that a batter needed 400 at bats, despite Lou Boudreau's attempt to bat Williams second in the lineup to get more at-bats. Williams led the league in base on balls with 136 which kept him from qualifying under the rules at the time. By today's standards (plate appearances) he would have been the champion. The rule was changed shortly thereafter to keep this from happening again.[36][119] On August 25, Williams passed Johnny Mize for sixth place, and on September 3, Williams passed Joe DiMaggio for fifth all-time in career home runs with his 362nd career home run. He finished the season with 366 career home runs.[120] On September 26, Williams "retired" after the Red Sox's final game of the season.[121]

During the off-season of 1954, Williams was offered the chance to be manager of the Red Sox. Williams declined, and he suggested that Pinky Higgins, who had previously played on the 1946 Red Sox team as the third baseman, become the manager of the team. Higgins later was hired as the Red Sox manager in 1955.[122] Williams sat out the first month of the 1955 season due to a divorce settlement with his wife, Doris. When Williams returned, he signed a $98,000 contract on May 13. Williams batted .356 in 320 at bats on the season, lacking enough at bats to win the batting title over Al Kaline, who batted .340.[123] Williams hit 28 home runs and drove in 83 runs[36] while being named the "Comeback Player of the Year."[124]

On July 17, 1956, Williams became the fifth player to hit 400 home runs, following Mel Ott in 1941, Jimmie Foxx in 1938, Lou Gehrig in 1936, and Babe Ruth in 1927.[125][126] Three weeks later at home against the Yankees on August7, after Williams was booed for dropping a fly ball from Mickey Mantle, he spat at one of the fans who was taunting him on the top of the dugout;[127] Williams was fined $5,000 for the incident.[128][129] The following night against Baltimore, Williams was greeted by a large ovation, and received an even larger one when he hit a home run in the sixth inning to break a 22 tie. In The Boston Globe, the publishers ran a "What Globe Readers Say About Ted" section made out of letters about Williams, which were either the sportswriters or the "loud mouths" in the stands. Williams explained years later, "From '56 on, I realized that people were for me. The writers had written that the fans should show me they didn't want me, and I got the biggest ovation yet".[130] Williams lost the batting title to Mickey Mantle in 1956, batting .345 to Mantle's .353, with Mantle on his way to winning the Triple Crown.[131]

In 1957, Williams batted .388 to lead the majors, then signed a contract in February 1958 for a record high $125,000 (or $135,000).[132][133] At age forty that season, he again led the American League with a .328 batting average.[134]

When Pumpsie Green became the first black player on the Red Soxthe last major league team to integratein 1959, Williams openly welcomed Green.[135]

Williams ended his career with a home run in his last at-bat on September 28, 1960. He refused to salute the fans as he returned the dugout after he crossed home plate or after he was replaced in left field by Carroll Hardy. An essay written by John Updike the following month for The New Yorker, "Hub Fans Bid Kid Adieu", chronicles this event.[136]

Williams is one of only 29 players in baseball history to date to have appeared in Major League games in four decades.[137]

Williams was an obsessive student of hitting. He famously used a lighter bat than most sluggers, because it generated a faster swing.[138] In 1970, he wrote a book on the subject, The Science of Hitting (revised 1986), which is still read by many baseball players.[138] The book describes his theory of swinging only at pitches that came into ideal areas of his strike zone, a strategy Williams credited with his success as a hitter. Pitchers apparently feared Williams; his bases-on-balls-to-plate-appearances ratio (.2065) is still the highest of any player in the Hall of Fame.

Williams nearly always took the first pitch.[139]

He helped pass his expertise of playing left-field in front of the Green Monster to his successor on the Red Sox, Carl Yastrzemski.[140]

Williams was on uncomfortable terms with the Boston newspapers for nearly twenty years, as he felt they liked to discuss his personal life as much as his baseball performance. He maintained a career-long feud with Sport due to a 1948 feature article in which the reporter included a quote from Williams's mother. Insecure about his upbringing, and stubborn because of immense confidence in his own talent, Williams made up his mind that the "knights of the keyboard", as he derisively labeled the press, were against him. After having hit for the league's Triple Crown in 1947, Williams narrowly lost the MVP award in a vote where one Midwestern newspaper writer left Williams entirely off his ten-player ballot.

During his career, some sportswriters also criticized aspects of Williams's baseball performance, including what they viewed as his lackadaisical fielding and lack of clutch hitting. Williams pushed back, saying: "They're always saying that I don't hit in the clutches. Well, there are a lot [of games] when I do."[141] He also asserted that it made no sense crashing into an outfield wall to try to make a difficult catch because of the risk of injury or being out of position to make the play after missing the ball.[142]

Williams treated most of the press accordingly, as he described in his 1969 memoir My Turn at Bat. Williams also had an uneasy relationship with the Boston fans, though he could be very cordial one-to-one. He felt at times a good deal of gratitude for their passion and their knowledge of the game. On the other hand, Williams was temperamental, high-strung, and at times tactless. In his biography, Ronald Reis relates how Williams committed two fielding miscues in a doubleheader in 1950 and was roundly booed by Boston fans. He bowed three times to various sections of Fenway Park and made an obscene gesture. When he came to bat he spat in the direction of fans near the dugout. The incident caused an avalanche of negative media reaction, and inspired sportswriter Austen Lake's famous comment that when Williams's name was announced the sound was like "autumn wind moaning through an apple orchard."

Another incident occurred in 1958 in a game against the Washington Senators. Williams struck out, and as he stepped from the batter's box swung his bat violently in anger. The bat slipped from his hands, was launched into the stands and struck a 60-year-old woman who turned out to be the housekeeper of the Red Sox general manager Joe Cronin. While the incident was an accident and Williams apologized to the woman personally, to all appearances it seemed at the time that Williams had hurled the bat in a fit of temper.

Williams gave generously to those in need. He was especially linked with the Jimmy Fund of the DanaFarber Cancer Institute, which provides support for children's cancer research and treatment. Williams used his celebrity to virtually launch the fund, which raised more than $750million between 1948 and 2010. Throughout his career, Williams made countless bedside visits to children being treated for cancer, which Williams insisted go unreported. Often parents of sick children would learn at check-out time that "Mr. Williams has taken care of your bill".[143] The Fund recently stated that "Williams would travel everywhere and anywhere, no strings or paychecks attached, to support the cause... His name is synonymous with our battle against all forms of cancer."[143]

Williams demanded loyalty from those around him. He could not forgive the fickle nature of the fansbooing a player for booting a ground ball, and then turning around and roaring approval of the same player for hitting a home run. Despite the cheers and adulation of most of his fans, the occasional boos directed at him in Fenway Park led Williams to stop tipping his cap in acknowledgment after a home run.

Williams maintained this policy up to and including his swan song in 1960. After hitting a home run at Fenway Park, which would be his last career at-bat, Williams characteristically refused either to tip his cap as he circled the bases or to respond to prolonged cheers of "We want Ted!" from the crowd by making an appearance from the dugout. The Boston manager Pinky Higgins sent Williams to his fielding position in left field to start the ninth inning, but then immediately recalled him for his back-up Carroll Hardy, thus allowing Williams to receive one last ovation as he jogged onto then off the field, and he did so without reacting to the crowd. Williams's aloof attitude led the writer John Updike to observe wryly that "Gods do not answer letters."[136]

Williams's final home run did not take place during the final game of the 1960 season, but rather in the Red Sox's last home game that year. The Red Sox played three more games, but they were on the road in New York City and Williams did not appear in any of them, as it became clear that Williams's final home at-bat would be the last one of his career.

In 1991, on Ted Williams Day at Fenway Park, Williams pulled a Red Sox cap from out of his jacket and tipped it to the crowd. This was the first time that he had done so since his earliest days as a player.

A Red Smith profile from 1956 describes one Boston writer trying to convince Ted Williams that first cheering and then booing a ballplayer was no different from a moviegoer applauding a "western" movie actor one day and saying the next "He stinks! Whatever gave me the idea he could act?" Williams rejected this; when he liked a western actor like Hoot Gibson, he liked him in every picture, and would not think of booing him.

Williams once had a friendship with Ty Cobb, with whom he often had discussions about baseball. He often touted Rogers Hornsby as being the greatest right-handed hitter of all time. This assertion actually led to a split in the relationship between Ty Cobb and Ted Williams. Once during one of their yearly debate sessions on the greatest hitters of all time, Williams asserted that Hornsby was one of the greatest of all time. Cobb apparently had strong feelings about Hornsby and he threw a fit, expelling Williams from his hotel room. Their friendship effectively terminated after this altercation.[144] This story was later refuted by Ted Williams himself.[145]

Williams served as a Naval Aviator during World War II and the Korean War. Unlike many other major league players, he did not spend all of his war-time playing on service teams.[146] Williams had been classified 3-A by Selective Service prior to the war, a dependency deferment because he was his mother's sole means of financial support. When his classification was changed to 1-A following the American entry into World War II, Williams appealed to his local draft board. The draft board ruled that his draft status should not have been changed. He made a public statement that once he had built up his mother's trust fund, he intended to enlist. Even so, criticism in the media, including withdrawal of an endorsement contract by Quaker Oats, resulted in his enlistment in the U.S. Naval Reserve on May 22, 1942.

Williams did not opt for an easy assignment playing baseball for the Navy, but rather joined the V-5 program to become a Naval aviator. Williams was first sent to the Navy's Preliminary Ground School at Amherst College for six months of academic instruction in various subjects including math and navigation, where he achieved a 3.85 grade point average.

Williams was talented as a pilot, and so enjoyed it that he had to be ordered by the Navy to leave training to personally accept his American League 1942 Major League Baseball Triple Crown.[146] Williams's Red Sox teammate, Johnny Pesky, who went into the same aviation training program, said this about Williams: "He mastered intricate problems in fifteen minutes which took the average cadet an hour, and half of the other cadets there were college grads." Pesky again described Williams's acumen in the advance training, for which Pesky personally did not qualify: "I heard Ted literally tore the sleeve target to shreds with his angle dives. He'd shoot from wingovers, zooms, and barrel rolls, and after a few passes the sleeve was ribbons. At any rate, I know he broke the all-time record for hits." Ted went to Jacksonville for a course in aerial gunnery, the combat pilot's payoff test, and broke all the records in reflexes, coordination, and visual-reaction time. "From what I heard. Ted could make a plane and its six 'pianos' (machine guns) play like a symphony orchestra", Pesky says. "From what they said, his reflexes, coordination, and visual reaction made him a built-in part of the machine."[147]

Williams completed pre-flight training in Athens, Georgia, his primary training at NAS Bunker Hill, Indiana, and his advanced flight training at NAS Pensacola. He received his gold Naval Aviator wings and his commission as a second lieutenant in the U.S. Marine Corps on May 2, 1944.

Williams served as a flight instructor at NAS Pensacola teaching young pilots to fly the complicated F4U Corsair fighter plane. Williams was in Pearl Harbor awaiting orders to join the Fleet in the Western Pacific when the War in the Pacific ended. He finished the war in Hawaii, and then he was released from active duty on January 12, 1946, but he did remain in the Marine Corps Reserve.[77]

On May 1, 1952, 14 months after his promotion to captain in the Marine Corps Reserve, Williams was recalled to active duty for service in the Korean War.[148] He had not flown any aircraft for eight years but he turned down all offers to sit out the war in comfort as a member of a service baseball team. Nevertheless, Williams was resentful of being called up, which he admitted years later, particularly regarding the Navy's policy of calling up Inactive Reservists rather than members of the Active Reserve.

Williams reported for duty on May 2, 1952. After eight weeks of refresher flight training and qualification in the F9F Panther jet fighter with VMF-223 at the Marine Corps Air Station Cherry Point, North Carolina, Williams was assigned to VMF-311, Marine Aircraft Group 33 (MAG-33), based at the K-3 airfield in Pohang, South Korea.[77]

On February 16, 1953, Williams, flying as the wingman for John Glenn (later an astronaut, then U.S. Senator), was part of a 35-plane raid against a tank and infantry training school just south of Pyongyang, North Korea. As the aircraft from VMF-115 and VMF-311 dove on the target, Williams's plane was hit by anti-aircraft fire, a piece of flak knocked out his hydraulics and electrical systems, causing Williams to have to "limp" his plane back to K-3 air base where he made a belly landing. For his actions of this day, he was awarded the Air Medal.[149]

Williams flew 39 combat missions in Korea, earning the Air Medal with two Gold Stars representing second and third awards, before being withdrawn from flight status in June 1953 after a hospitalization for pneumonia. This resulted in the discovery of an inner ear infection that disqualified him from flight status.[150] John Glenn described Williams as one of the best pilots he knew,[146] while his wife Annie described him as the most profane man she ever met.[151] In the last half of his missions, Williams was flying as Glenn's wingman.[152]

Williams likely would have exceeded 600 career home runs if he had not served in the military, and might even have approached Babe Ruth's then record of 714. He might have set the record for career RBIs as well, exceeding Hank Aaron's total.[146] While the absences in the Marine Corps took almost five years out of his baseball career, he never publicly complained about the time devoted to service in the Marine Corps. His biographer, Leigh Montville, argued that Williams was not happy about being pressed into service in South Korea, but he did what he thought was his patriotic duty.

Following his return to the United States in August 1953, he resigned his Reserve commission to resume his baseball career.[148]

After retirement from play, Williams helped Boston's new left fielder, Carl Yastrzemski, in hitting, and was a regular visitor to the Red Sox' spring training camps from 1961 to 1966, where he worked as a special batting instructor. He served as executive assistant to Tom Yawkey (196165), then was named a team vice president (196568) upon his election to the Hall of Fame. He resumed his spring training instruction role with the club in 1978.

Beginning in 1961, he would spend summers at the Ted Williams Baseball Camp in Lakeville, Massachusetts, which he had established in 1958 with his friend Al Cassidy and two other business partners. For eight summers and parts of others after that, he would give hitting clinics and talk baseball at the camp.[5] It was not uncommon to find Williams fishing in the pond at the camp. The area now is owned by the town and a few of the buildings still stand. In the main lodge one can still see memorabilia from Williams's playing days.

Williams served as manager of the Washington Senators, from 19691971, then continued with the team when they became the Texas Rangers after the 1971 season. Williams's best season as a manager was 1969 when he led the expansion Senators to an 8676 record in the team's only winning season in Washington. He was chosen "Manager of the Year" after that season. Like many great players, Williams became impatient with ordinary athletes' abilities and attitudes, particularly those of pitchers, whom he admitted he never respected. Fellow manager Alvin Dark thought Williams "was a smart, fearless manager" who helped his hitters perform better. Williams's issue with Washington/Texas, according to Dark, was when the ownership traded away his third baseman and shortstop, making it difficult for the club to be as competitive.[153]

On the subject of pitchers, in Ted's autobiography written with John Underwood, Ted opines regarding Bob Lemon (a sinker-ball specialist) pitching for the Cleveland Indians around 1951: "I have to rate Lemon as one of the very best pitchers I ever faced. His ball was always moving, hard, sinking, fast-breaking. You could never really uhmmmph with Lemon."

Williams was much more successful in fishing. An avid and expert fly fisherman and deep-sea fisherman, he spent many summers after baseball fishing the Miramichi River, in Miramichi, New Brunswick. Williams was named to the International Game Fish Association Hall of Fame in 2000. Williams, Jim Brown, Cumberland Posey, and Cal Hubbard are the only athletes to be inducted into the Halls of Fame of more than one professional sport. Williams was also known as an accomplished hunter; he was fond of pigeon-shooting for sport in Fenway Park during his career, on one occasion drawing the ire of the Massachusetts Society for the Prevention of Cruelty to Animals.[154]

Williams reached an extensive deal with Sears, lending his name and talent toward marketing, developing, and endorsing a line of in-house sports equipmentsuch as the "Ted Williams" edition Gamefisher aluminum boat and 7.5hp "Ted Williams" edition motor, as well as fishing, hunting, and baseball equipment. Williams continued his involvement in the Jimmy Fund, later losing a brother to leukemia, and spending much of his spare time, effort, and money in support of the cancer organization.

In his later years Williams became a fixture at autograph shows and card shows after his son (by his third wife), John Henry Williams, took control of his career, becoming his de facto manager. The younger Williams provided structure to his father's business affairs, exposed forgeries that were flooding the memorabilia market, and rationed his father's public appearances and memorabilia signings to maximize their earnings.

One of Ted Williams's final, and most memorable, public appearances was at the 1999 All-Star Game in Boston. Able to walk only a short distance, Williams was brought to the pitcher's mound in a golf cart. He proudly waved his cap to the crowda gesture he had never done as a player. Fans responded with a standing ovation that lasted several minutes. At the pitcher's mound he was surrounded by players from both teams, including fellow Red Sox player Nomar Garciaparra, and was assisted by Tony Gwynn in throwing out the first pitch of that year's All-Star Game. Later in the year, he was among the members of the Major League Baseball All-Century Team introduced to the crowd at Turner Field in Atlanta prior to Game Two of the World Series.

On May 4, 1944, Williams married Doris Soule, the daughter of his hunting guide. Their daughter, Barbara Joyce ("Bobbi Jo"), was born on January 28, 1948, while Williams was fishing in Florida.[155] They divorced in 1954. Williams married the socialite model Lee Howard on September 10, 1961, and they were divorced in 1967.

Williams married Dolores Wettach, a former Miss Vermont and Vogue model, in 1968. Their son John-Henry was born on August 27, 1968, followed by daughter Claudia, on October 8, 1971. They were divorced in 1972.[156]

Williams lived with Louise Kaufman for twenty years until her death in 1993. In his book, Cramer called her the love of Williams's life.[157] After his death, her sons filed suit to recover her furniture from Williams's condominium as well as a half-interest in the condominium they claimed he gave her.[158]

Williams had a strong respect for General Douglas MacArthur, referring to him as his "idol".[159] For Williams's 40th birthday, MacArthur sent him an oil painting of himself with the inscription "To Ted Williamsnot only America's greatest baseball player, but a great American who served his country. Your friend, Douglas MacArthur. General U.S. Army."[160]

Politically, Williams was a Republican,[161] and was described by one biographer as, "to the right of Attila the Hun" except when it came to Civil Rights.[162] Another writer similarly noted that while in the 1960s he had a liberal attitude on civil rights, he was pretty far right on other cultural issues of the time, calling him ultraconservative in the tradition of Barry Goldwater and John Wayne.[161]

Williams campaigned for Richard Nixon in the 1960 United States Presidential Election, and after Nixon lost to John F. Kennedy, refused several invitations from President Kennedy to gather together in Cape Cod. He supported Nixon again in 1968, and as manager of the Senators, kept a picture of him on his desk, meeting with the President several times while managing the team. In 1972 he called Nixon, the greatest president of my lifetime.[161] In the following years, Williams endorsed several other candidates in Republican Party presidential primaries, including George H. W. Bush in 1988 (whom he also campaigned for in New Hampshire),[163] Bob Dole in 1996, and George W. Bush in 2000.[164]

According to friends, Williams was an atheist[165] and this influenced his decision to be cryogenically frozen. His daughter Claudia stated "It was like a religion, something we could have faith in... no different from holding the belief that you might be reunited with your loved ones in heaven".[166]

Williams's brother Danny and his son John-Henry both died of leukemia.[167]

In his last years, Williams suffered from cardiomyopathy. He had a pacemaker implanted in November 2000 and he underwent open-heart surgery in January 2001. After suffering a series of strokes and congestive heart failure, he died of cardiac arrest at the age of 83 on July 5, 2002, at Citrus Memorial Hospital, Inverness, Florida, near his home in Citrus Hills, Florida.[168]

Though his will stated his desire to be cremated and his ashes scattered in the Florida Keys, Williams's son John-Henry and younger daughter Claudia chose to have his remains frozen cryonically.

Ted's elder daughter, Bobby-Jo Ferrell, brought a suit to have her father's wishes recognized. John-Henry's lawyer then produced an informal "family pact" signed by Ted, Claudia, and John-Henry, in which they agreed "to be put into biostasis after we die" to "be able to be together in the future, even if it is only a chance."[169] Bobby-Jo and her attorney, Spike Fitzpatrick (former attorney of Ted Williams), contended that the family pact, which was scribbled on an ink-stained napkin, was forged by John-Henry and/or Claudia.[170] Fitzpatrick and Ferrell believed that the signature was not obtained legally.[171] Laboratory analysis proved that the signature was genuine.[171] John-Henry said that his father was a believer in science and was willing to try cryonics if it held the possibility of reuniting the family.[172]

Though the family pact upset some friends, family and fans, a public plea for financial support of the lawsuit by Ferrell produced little result.[172] Citing financial difficulties, Ferrell dropped her lawsuit on the condition that a $645,000 trust fund left by Williams would immediately pay the sum out equally to the three children.[172] Inquiries to cryonics organizations increased after the publicity from the case.[170]

In Ted Williams: The Biography of an American Hero, author Leigh Montville claims that the family cryonics pact was a practice Ted Williams autograph on a plain piece of paper, around which the agreement had later been hand written. The pact document was signed "Ted Williams", the same as his autographs, whereas he would always sign his legal documents "Theodore Williams", according to Montville. However, Claudia testified to the authenticity of the document in an affidavit.[173]

Williams body was subsequently decapitated for the neuropreservation option from Alcor.[174] Following John-Henry's unexpected illness and death from acute myeloid leukemia on March 6, 2004, John-Henry's body was also transported to Alcor, in fulfillment of the family agreement.[175]

In 1954, Williams was inducted by the San Diego Hall of Champions into the Breitbard Hall of Fame honoring San Diego's finest athletes both on and off the playing surface.[176]

Williams was inducted into the Baseball Hall of Fame on July 25, 1966.[177] In his induction speech, Williams included a statement calling for the recognition of the great Negro leagues players: "I've been a very lucky guy to have worn a baseball uniform, and I hope some day the names of Satchel Paige and Josh Gibson in some way can be added as a symbol of the great Negro players who are not here only because they weren't given a chance."[178] Williams was referring to two of the most famous names in the Negro leagues, who were not given the opportunity to play in the Major Leagues before Jackie Robinson broke the color barrier in 1947. Gibson died early in 1947 and thus never played in the majors; and Paige's brief major league stint came long past his prime as a player. This powerful and unprecedented statement from the Hall of Fame podium was "a first crack in the door that ultimately would open and include Paige and Gibson and other Negro league stars in the shrine."[178] Paige was the first inducted in 1971. Gibson and others followed, starting in 1972 and continued on and off into the 21st century.

On November 18, 1991, President George H. W. Bush presented Williams with the Presidential Medal of Freedom, the highest civilian award in the US.[179]

The Ted Williams Tunnel in Boston, Massachusetts, carrying 1.6 miles (2.6km) of the final 2.3 miles (3.7km) of Interstate 90 under Boston Harbor, opened in December 1995, and Ted Williams Parkway (California State Route 56) in San Diego County, California, opened in 1992, were named in his honor while he was still alive. In 2016, the major league San Diego Padres inducted Williams into their hall of fame for his contributions to baseball in San Diego.[180]

The Tampa Bay Rays home field, Tropicana Field, installed the Ted Williams Museum (formerly in Hernando, Florida, 19942006) behind the left field fence. From the Tampa Bay Rays website: "The Ted Williams Museum and Hitters Hall of Fame brings a special element to the Tropicana Field. Fans can view an array of different artifacts and pictures of the 'Greatest hitter that ever lived.' These memorable displays range from Ted Williams's days in the military through his professional playing career. This museum is dedicated to some of the greatest players to ever 'lace 'em up,' including Willie Mays, Joe DiMaggio, Mickey Mantle, Roger Maris."

In 2013, the Bob Feller Act of Valor Award honored Williams as one of 37 Baseball Hall of Fame members for his service in the United States Marine Corps during World War II.[181]

At the time of his retirement, Williams ranked third all-time in home runs (behind Babe Ruth and Jimmie Foxx), seventh in RBIs (after Ruth, Cap Anson, Lou Gehrig, Ty Cobb, Foxx, and Mel Ott), and seventh in batting average (behind Cobb, Rogers Hornsby, Shoeless Joe Jackson, Lefty O'Doul, Ed Delahanty and Tris Speaker). His career batting average of .3444 is the highest of any player who played his entire career in the live-ball era following 1920.

Most modern statistical analyses[which?] place Williams, along with Ruth and Barry Bonds, among the three most potent hitters to have played the game. Williams's baseball season of 1941 is often considered favorably with the greatest seasons of Ruth and Bonds in terms of various offensive statistical measures such as slugging, on-base and "offensive winning percentage." As a further indication, of the ten best seasons for OPS, short for On-Base Plus Slugging Percentage, a popular modern measure of offensive productivity, four each were achieved by Ruth and Bonds, and two by Williams.

In 1999, Williams was ranked as number eight on The Sporting News' list of the 100 Greatest Baseball Players, where he was the highest-ranking left fielder.[182]

Visit link:

Ted Williams - Wikipedia

Posted in Cryonics | Comments Off on Ted Williams – Wikipedia

Fact check: False claim Biden’s executive order limits human rights

Posted: at 5:14 am

Biden blames Putin for war against Ukraine during UN speech

President Joe Biden called out President Vladimir Putin for the war against Ukraine as he pledged support for sovereign nations at United Nations.

Claire Hardwick, Associated Press

On Sept. 12, President Joe Biden signed an executive order to invest inbiotechnology and biomanufacturing innovation to advance health, climate and other matters.But some online claimthe order is linked to something more nefarious.

"The plan is no longer secret. Biden's Sept. 12, 2022 Executive Order declares that Americans must surrender all human rights that stand in the way of transhumanism," reads an Instagram post shared Sept. 18.

The post also claims that clinical trial safety standards and informed consent will be eradicated and thatthe executive order is implementing crimes against humanity"in order to achievethe societal goals of the new world order."

The post generated over 350likes in less than a week.

Follow us on Facebook! Like our page to get updates throughout the day on our latest debunks

But the claim is baseless.

Global health and human rights experts told USA TODAY the executive order does not eradicate human rights in any way or even relate to the transhumanism movement. The claim is tied to the baseless new world order conspiracy theory, which USA TODAY has previously debunked.

USA TODAY reached out to the social media user who shared the claim for comment.

The claim is "totally off and not true," Samantha Reposa, a White House spokesperson, told USA TODAY in an email.

There is nothing in Biden'sexecutive order that weakens existing human rights protections in any way,Arthur Applbaum, a professor of democratic values at the Harvard Kennedy School of Government, told USA TODAY in an email.

The second sentence of the order says, Central to this policy and its outcomes are principles of equity, ethics, safety, and security, and this is not mere happy talk, Applbaum said. The executive order attends to these considerations throughout.

The order also saysBiden's administration "must ensure that uses of biotechnology and biomanufacturing are ethical and responsible; are centered on a foundation of equity and public good…and are consistent with respect for human rights.

Fact check: Biden's executive order will evaluate concept of a digital currency, not launch it

Transhumanism, which the post invokes, refers to the idea of using permanently integratedtechnology to increase human perception, emotions or intelligence. Biden's order has nothing to do with this concept, Lawrence Gostin, a professor of global health law at Georgetown University, told USA TODAY in an email. He noted the post's claims about human trials are also baseless participants still have a right to informed consent and there remain strong safety standards in clinical trials, Gostin said.

The new world order conspiracy theoryclaims that a cabal of elites are working to implement a government structure that would enslave the global populace and eliminate freedoms, according to the Middleburg Institute of International Studies. USA TODAY has debunked the conspiracy theorys claims before.

The post also ties this conspiracy theory to crimes against humanity, which is defined by the Rome Statute of the International Criminal Court as a systematic attack directed against any civilian population, according to the United Nations.The order references nothing of the sort.

Based on our research, we rate FALSE the claim that Bidens executive order declares that Americans must surrender human rights. The executive order says that central to its objectives are the principles of safety and equity, and thatBiden's administration must ensurethat uses of biotechnology are consistent with respecting human rights. As experts confirm, the order has nothing to do with limiting human rights related to transhumanism or anything else.

Thank you for supporting our journalism. You can subscribe to our print edition, ad-free app or electronic newspaper replica here.

Our fact-check work is supported in part by a grant from Facebook.

Continue reading here:

Fact check: False claim Biden's executive order limits human rights

Posted in Transhumanism | Comments Off on Fact check: False claim Biden’s executive order limits human rights

Transfection to Transhumanism – Part 1 – rumble.com

Posted: at 5:14 am

Dr. Robert O. Young shares his research at the BioMed Expo in Las Vegas, Nevada on, "All of Humanity at Risk - Transfection of Graphene & Parasites Activated by 3, 4 & 5G Pulsating EMF!"

To All My Family and Friends Around the World,

"It is easier to fool people than it is to convince them they've been fooled." Mark Twain

Watch Part 2 and read the entire article at: https://www.drrobertyoung.com/post/humanity-at-risk-transfection-of-graphene-parasites-activated-by-3-4-5g-pulsating-emf

Robert O. Young MSc, DSc, PhD, Naturopathic Practitioner - http://www.drrobertyoung.com

Support the work, research and findings of Dr. Robert O. Young at: https://www.givesendgo.com/research

No donation is too small and will be appreciated and used for continuous research, publications and public education!

As a special thank you for your donation, I will answer one health or lifestyle related question.

After your donation, please email me at: phmiraclelife@gmail.com

Keep your question short and very specific. Please include your first and last name, phone number and email. Your question will be answered within 72 hours.

God bless YOU ALL!

Stay healthy and happy! http://www.givesendgo.com/researchwww.drrobertyoung.com/blog

Continue reading here:

Transfection to Transhumanism - Part 1 - rumble.com

Posted in Transhumanism | Comments Off on Transfection to Transhumanism – Part 1 – rumble.com

CapitalGainsReport Sector Spotlight: Healthcare Penny Stocks On The Move (ARDX, WHSI, BNGO) – Marketscreener.com

Posted: at 5:13 am

CapitalGainsReport Sector Spotlight: Healthcare Penny Stocks On The Move (ARDX, WHSI, BNGO)  Marketscreener.com

Continue reading here:
CapitalGainsReport Sector Spotlight: Healthcare Penny Stocks On The Move (ARDX, WHSI, BNGO) - Marketscreener.com

Posted in Genome | Comments Off on CapitalGainsReport Sector Spotlight: Healthcare Penny Stocks On The Move (ARDX, WHSI, BNGO) – Marketscreener.com

IFrame API | Jitsi Meet – GitHub Pages

Posted: at 5:12 am

Embedding the Jitsi Meet API into your site or app enables you to host and provide secure video meetings with your colleagues, teams, and stakeholders. The Meet API provides a full complement of comprehensive meeting features.

Your Jitsi meetings can be hosted and attended using any device while keeping your data and privacy protected. You can reach your meeting participants anywhere in the world eliminating the need for travel and the associated inconvenience.

The IFrame API enables you to embed Jitsi Meet functionality into your meeting application so you can experience the full functionality of the globally distributed and highly available deployment available with meet.jit.si.

You can also embed and integrate the globally distributed and highly available deployment on the meet.jit.si platform itself.

JaaS customers, please make sure you also read this!

If you use React in your web application you might want to use our React SDK instead.

To enable the Jitsi Meet API in your application you must use one of the following JavaScript (JS) Jitsi Meet API library scripts and integrate it into your application:

For self-hosting in your domain:

meet.jit.si:

The iframe API works on mobile browsers the same way as it does on desktop browsers.

In order to open meetings with the Jitsi Meet app you can use our custom URL scheme as follows:

(let's assume the meeting is https://meet.jit.si/test123)

This works with custom servers too, just replace meet.jit.si with your custom server URL.

After you have integrated the Meet API library, you must then create the Jitsi Meet API object.

The Meet API object takes the following form:

api = new JitsiMeetExternalAPI(domain, options)

The API object constructor uses the following options:

domain: The domain used to build the conference URL (e.g., meet.jit.si).

options: The object with properties.

Optional arguments include:

roomName: The name of the room to join.

width: The created IFrame width.

The width argument has the following characteristics:

A numerical value indicates the width in pixel units.

If a string is specified the format is a number followed by px, em, pt, or %.

height: The height for the created IFrame.

The height argument has the following characteristics:

A numerical value indicates the height in pixel units.

If a string is specified the format is a number followed by px, em, pt, or %.

parentNode: The HTML DOM Element where the IFrame is added as a child.

configOverwrite: The JS object with overrides for options defined in the config.js file.

interfaceConfigOverwrite: The JS object with overrides for options defined in the interface_config.js file.

jwt: The JWT token.

onload: The IFrame onload event handler.

invitees: Object arrays that contain information about participants invited to a call.

devices: Information map about the devices used in a call.

userInfo: The JS object that contains information about the participant starting the meeting (e.g., email).

lang: The default meeting language.

For example:

You can set the initial media devices for the call using the following:

You can override options set in the config.js file and the interface_config.js file using the configOverwrite and interfaceConfigOverwrite objects, respectively.

For example:

To pass a JWT token to Jitsi Meet use the following:

You can set the userInfo (e.g., email, display name) for the call using the following:

Configuring the tile view:

You can configure the maximum number of columns in the tile view by overriding the TILE_VIEW_MAX_COLUMNS property from the interface_config.js file via the interfaceConfigOverwrite object:

TILE_VIEW_MAX_COLUMNS accepts values from 1 to 5. The default value is 5.

All functions are documented here now.

All commands are documented here now.

All events are documented here now.

Read this article:
IFrame API | Jitsi Meet - GitHub Pages

Posted in Jitsi | Comments Off on IFrame API | Jitsi Meet – GitHub Pages

Canadian religious leaders speak out as country set to allow euthanasia for mental illness – Fox News

Posted: at 5:11 am

  1. Canadian religious leaders speak out as country set to allow euthanasia for mental illness  Fox News
  2. Protect life until the end, archbishop tells health workers  The Catholic Register
  3. Death on Demand | Gene Veith  Patheos
  4. Health workers called to love, and possibly conscientious objection, archbishop says  The B.C. Catholic
  5. Renu Bakshi: Calm before the storm upcoming death laws test Canadas woke values  Business in Vancouver
  6. View Full Coverage on Google News

Continued here:

Canadian religious leaders speak out as country set to allow euthanasia for mental illness - Fox News

Posted in Euthanasia | Comments Off on Canadian religious leaders speak out as country set to allow euthanasia for mental illness – Fox News

From @Breakingviews: China’s Tech Giants Will Have to Keep on Giving, Says @ywchen1 – Latest Tweet by – LatestLY

Posted: at 5:09 am

From @Breakingviews: China's Tech Giants Will Have to Keep on Giving, Says @ywchen1 - Latest Tweet by  LatestLY

More:

From @Breakingviews: China's Tech Giants Will Have to Keep on Giving, Says @ywchen1 - Latest Tweet by - LatestLY

Comments Off on From @Breakingviews: China’s Tech Giants Will Have to Keep on Giving, Says @ywchen1 – Latest Tweet by – LatestLY

List of territorial disputes – Wikipedia

Posted: at 5:07 am

TerritoryClaimantsNotesAbagaitu IsletRussiaPeople's Republic of China[note 1]Republic of China[note 1][note 2]Generally held to have been resolved in October 2004 by the Complementary Agreement between the People's Republic of China and the Russian Federation on the Eastern Section of the China-Russia Boundary. However, the settlement is not recognized by the Republic of China.[note 2]AbkhaziaRepublic of AbkhaziaGeorgiaDepsang Plains, Aksai ChinPeople's Republic of China[note 1]Republic of China[note 1]IndiaArunachal Pradesh / South TibetIndiaPeople's Republic of China[note 1]Republic of China[note 1]Controlled by India but claimed by the PRC and ROC who dispute the validity of the McMahon Line.Bch Long V IslandVietnamRepublic of China[note 2]Ceded to Vietnam by the PRC in 1957.[70] However, the settlement is not recognized by the Republic of China.[note 2]Chinese side of Baekdu Mountain[71]People's Republic of ChinaSouth KoreaRepublic of China[note 2]Settled by the PRC and DPRK in 1962. However, the settlement is not recognized by the Republic of China,[note 2] and the Republic of Korea.Korean side of Baekdu Mountain[71]North KoreaSouth KoreaRepublic of China[note 2]Also formerly claimed by the PRC until 1962.Beyul Khenpajong, the Menchuma Valley, and Chagdzom[72]BhutanPeople's Republic of China[note 1]Republic of China[note 1]Eastern part of BhutanBhutanRepublic of China[note 2]Bhutanese exclaves in western Tibet, namely Cherkip Gompa, Dho, Dungmar, Gesur, Gezon, Itse Gompa, Khochar, Nyanri, Ringung, Sanmar, Darchen, Doklam, and ZuthulphukPeople's Republic of China[note 1]Republic of China[note 1]BhutanDadivankAzerbaijanArmeniaArtsakhUnder the military control of Russian peacekeepers since 2020.Demchok sector / Parigas regionIndiaPeople's Republic of China[note 1]Republic of China[note 1]Chumar, Gue, Kaurik, Shipki La, Tashigang, Barahoti, Lapthal, Jadhang, Nelang, Pulam Sumda and SangIndiaPeople's Republic of China[note 1]Republic of China[note 1]Controlled by India but claimed by Zanda County, Ngari Prefecture, Tibet, China. Disputed areas located between Aksai Chin and Nepal.Gaza Strip Gaza Strip PalestineIsraelDe facto administrated by Hamas since July 2007.A small area of Gilgit-BaltistanPakistanIndiaRepublic of China[note 2]3,700 square miles (9,600km2) of territory in Gilgit-Baltistan, and the Siachen Glacier[73]PakistanIndiaRepublic of China[note 1])the People's Republic of China relinquished its claim to Pakistan. India and the Republic of China did not.James ShoalMalaysiaPeople's Republic of China[note 1]Republic of China[note 1]North CyprusTurkish Republic of Northern CyprusRepublic of CyprusNorthern Cyprus (a state with limited recognition) controls and administers the northern part of the island.The Republic of Cyprus claims the whole island.Macclesfield BankPeople's Republic of China[note 1]Republic of China[note 1]PhilippinesMainland China, Hainan, and other areas controlled by the PRCPeople's Republic of China[note 1]Republic of China[note 1]Moldovan-controlled area of Dubsari districtMoldovaPridnestrovian Moldavian RepublicKokkina/Erenky exclaveTurkish Republic of Northern CyprusRepublic of CyprusNorthern Cyprus controls and administers Kokkina, an area separated from the rest of the main land on Northern Cyprus via the land controlled by the Republic of Cyprus.Heixiazi / Bolshoy Ussuriysky Island(eastern half)RussiaRepublic of China[note 2]Generally held to have been resolved in October 2004 by the Complementary Agreement between the People's Republic of China and the Russian Federation on the Eastern Section of the China-Russia Boundary. However, the settlement is not recognized by the Republic of China.[note 2]Heixiazi / Bolshoy Ussuriysky Island(western half)People's Republic of China[note 1]Republic of China[note 1]Hong KongPeople's Republic of China[note 1]Republic of China[note 1]Former ROC president Lee Teng-hui claimed that Hong Kong should have been returned to the ROC instead of the PRC because the ROC government had the original manuscript of the Treaty of Nanking.[74]JiangxinpoMyanmarRepublic of China[note 2]Northern parts of Sagaing Region and Kachin State, claimed by the Republic of China as part of Yunnan. Formerly claimed by the People's Republic of China until 1961.944km2 of territory on the ChinaKazakhstan borderKazakhstanPeople's Republic of China[note 1]Republic of China[note 1][note 2]The Kazakh Government ceded 407km2 to the PRC, and the PRC ceded 537km2 to Kazakhstan in 1999. However, the settlement is not recognized by the Republic of China.[note 2]Khan Tengri peak, the Boz-Tik site, the Bedel pass, the Uzongu-Kuush valley, and the Erkeshtam pass[75]KyrgyzstanPeople's Republic of China[note 1]Republic of China[note 1][note 2]In an agreement signed in 1999, the Khan Tengri peak, the Boz-Tik site, the Bedel pass, and the Erkeshtam pass were ceded to the Kyrgyz government while the Uzongu-Kuush valley was ceded to the PRC. However, the settlement is not recognized by the Republic of China.[note 2]KosovoRepublic of KosovoSerbiaKosovo is the subject of a territorial dispute between the Republic of Serbia and the self-proclaimed Republic of Kosovo. The latter declared independence on 17 February 2008, while Serbia claims it as part of its own sovereign territory. Its independence is recognized by 97 UN member states.Kula Kangri and mountainous areas to the west of this peak, plus the western Haa District of BhutanBhutanPeople's Republic of China[note 1]Republic of China[note 1]Kutuzov IslandRussiaRepublic of China[note 2]Lachin corridorArtsakhAzerbaijanArmeniaUnder the military control of Russian peacekeepers since 2020.MacauPeople's Republic of China[note 1]Republic of China[note 1]Both the PRC and the ROC officially consider themselves to be the sole legitimate government over the entirety of China.Nagorno-Karabakh regionArtsakhAzerbaijanArmeniaInternationally recognized as part of Azerbaijan,[76] de facto controlled by the Republic of Artsakh supported by Armenia.Namwan Assigned TractMyanmarRepublic of China[note 2]Settled by Myanmar and the PRC in the Sino-Burmese Boundary Treaty in 1960 and officially ceded to Myanmar in 1961.[77] However, the settlement is not recognized by the Republic of China.[note 2]Outer MongoliaMongoliaRepublic of China[note 1]The Republic of China briefly recognized Mongolia's independence between 1945 and 1952, and from 2002 onwards; however, under the Constitution of the Republic of China, the ROC claim on Mongolia cannot be withdrawn without recourse to a referendum.Pamir MountainsTajikistanPeople's Republic of China[note 1]Republic of China[note 1][note 2]The Tajik Government ceded 1,158km2 to the PRC, while PRC relinquished its 73,000km2 claim over the remaining territory with final ratification of a treaty in January 2011.[78][note 2] However, the settlement is not recognized by the Republic of China.[note 2]Paracel Islands[1]People's Republic of China[note 1]Republic of China[note 1]VietnamEntirely controlled by the People's Republic of China but claimed by the Republic of China and Vietnam.[79]Parangcho[80]South KoreaPeople's Republic of ChinaRepublic of China[note 2]Rasu, Kimathanka, Nara Pass, Tingribode, and Mount EverestNepalRepublic of China[note 2]Settled by Nepal and the PRC in 1960.[81] However, the settlement is not recognized by the Republic of China.[note 2]Scarborough ShoalPeople's Republic of China[note 1]Republic of China[note 1]PhilippinesControlled by the PRC since the 2012 Scarborough Shoal standoff.Sakteng Wildlife Sanctuary[82]BhutanPeople's Republic of China[note 1]Republic of China[note 1]Senkaku Islands (Diaoyu Tai or Diaoyu Dao)[1]JapanPeople's Republic of China[note 1]Republic of China[note 1]Controlled by Japan but claimed by the PRC and ROC.[83]Shaksgam ValleyPeople's Republic of China[note 1]Republic of China[note 1]IndiaPakistan was originally a party to the dispute but relinquished its claim and accepted Chinese sovereignty over the area in 1963.Sixty-Four Villages East of the RiverRussiaRepublic of China[note 2]Republic of SomalilandSomalilandSomaliaSouth OssetiaRepublic of South OssetiaGeorgiaSpratly IslandsPeople's Republic of China[note 1]Republic of China[note 1]VietnamPhilippines (part)Malaysia (part)Brunei (part)Each of the claimant countries except Brunei controls one or more of the individual islands.'Border' checkpoint near StroviliaUnited KingdomTurkish Republic of Northern CyprusNorthern Cyprus controls and administers the border checkpoint near Strovilia.UK's claim in regard to its Sovereign Base AreasTechnically, of course, this also involves Cyprus; the checkpoint is partially on UN-administered land, and Cyprus claims all of the island. (See: Europe)Taiwan, Penghu, Kinmen, Matsu, Pratas Island, and the Vereker BanksRepublic of China[84][note 1]People's Republic of China[85][note 1]The government of the People's Republic of China claims the entire island of Taiwan, as well as a number of minor islands, such as Penghu, Kinmen, and Matsu, that are controlled by the Republic of China. See also: Anti-Secession Law, Political status of Taiwan.Trans-Karakoram TractsPeople's Republic of China[note 1]Republic of China[note 1]IndiaTransnistria (including Bendery)Pridnestrovian Moldavian RepublicMoldovaTannu UriankhaiRussiaRepublic of China[note 1]Originally part of China during the Qing dynasty but came under Russian influence in the 20th century. Sovereignty over the area has not been officially relinquished by the ROC. However, the claim is not actively pursued by the ROC government.Tumen River (disputed sovereignty of certain islands)[1][note 3]People's Republic of China[note 1]North KoreaRepublic of China[note 1][note 2]South KoreaTumen River mouthNorth KoreaSouth KoreaRepublic of China[note 2]Navigation and control of the mouth of the river Tumen is disputed between the Republic of China and DPRK along with the Republic of Korea.Varnita and CopancaMoldovaPridnestrovian Moldavian RepublicEastern part of Wakhan CorridorAfghanistanRepublic of China[note 2]The border was established between Afghanistan and China in an agreement between the British and the Russians in 1895 as part of the Great Game, although the Chinese and Afghans did not finally agree on the border until 1963.[86][87] The Kingdom of Afghanistan and the People's Republic of China demarcated their border in 1963.[86][88][note 2] However, the settlement is not recognized by the Republic of China.[note 2]Western SaharaMoroccoSahrawi Arab Democratic RepublicThe United Nations keeps the Western Sahara in its list of non-self-governing territories and considers the sovereignty issue as unresolved pending a final solution. To that end, the UN sent a mission in the territory to oversee a referendum on self-determination in 1991, but it never happened. Administration was relinquished by Spain in 1976.Yalu River (disputed sovereignty of certain islands)[1][note 3]People's Republic of China[note 1]North KoreaRepublic of China[note 1][note 2]South KoreaGenerally held to have been resolved in 2005. North Korea is allocated all of the large islands in the lower Yalu River, including Pidan and Sindo at the mouth.[89] The river's maritime rights remain shared between North Korea and the PRC. However, the settlement is not recognized by the Republic of China.[note 2]

Follow this link:

List of territorial disputes - Wikipedia

Comments Off on List of territorial disputes – Wikipedia

First-degree atrioventricular block – Wikipedia

Posted: at 5:07 am

Medical condition

First-degree atrioventricular block (AV block) is a disease of the electrical conduction system of the heart in which electrical impulses conduct from the cardiac atria to the ventricles through the atrioventricular node (AV node) more slowly than normal. First degree AV block does not generally cause any symptoms, but may progress to more severe forms of heart block such as second- and third-degree atrioventricular block. It is diagnosed using an electrocardiogram, and is defined as a PR interval greater than 200 milliseconds.[1] First degree AV block affects 0.65-1.1% of the population with 0.13 new cases per 1000 persons each year.

The most common causes of first-degree heart block are AV nodal disease, enhanced vagal tone (for example in athletes), myocarditis, acute myocardial infarction (especially acute inferior MI), electrolyte disturbances and medication. The medications that most commonly cause first-degree heart block are those that increase the refractory time of the AV node, thereby slowing AV conduction. These include calcium channel blockers, beta-blockers, cardiac glycosides, and anything that increases cholinergic activity such as cholinesterase inhibitors.[2]

In normal individuals, the AV node slows the conduction of electrical impulses through the heart. This is manifest on a surface electrocardiogram (ECG) as the PR interval. The normal PR interval is from 120 ms to 200 ms in length. This is measured from the initial deflection of the P wave to the beginning of the QRS complex.[3]

In first-degree heart block, the diseased AV node conducts the electrical activity more slowly. This is seen as a PR interval greater than 200 ms in length on the surface ECG. It is usually an incidental finding on a routine ECG.[4]

First-degree heart block does not require any particular investigations except for electrolyte and drug screens, especially if an overdose is suspected.[5]

The management includes identifying and correcting electrolyte imbalances and withholding any offending medications. This condition does not require admission unless there is an associated myocardial infarction. Even though it usually does not progress to higher forms of heart block, it may require outpatient follow-up and monitoring of the ECG, especially if there is a comorbid bundle branch block. If there is a need for treatment of an unrelated condition, care should be taken not to introduce any medication that may slow AV conduction. If this is not feasible, clinicians should be very cautious when introducing any drug that may slow conduction; and regular monitoring of the ECG is indicated.[6]

Isolated first-degree heart block has no direct clinical consequences. There are no symptoms or signs associated with it. It was originally thought of as having a benign prognosis. In the Framingham Heart Study, however, the presence of a prolonged PR interval or first degree AV block doubled the risk of developing atrial fibrillation, tripled the risk of requiring an artificial pacemaker, and was associated with a small increase in mortality. This risk was proportional to the degree of PR prolongation.[7]

A subset of individuals with the triad of first-degree heart block, right bundle branch block, and either left anterior fascicular block or left posterior fascicular block (known as trifascicular block) may be at an increased risk of progression to complete heart block.[8]

See the original post:

First-degree atrioventricular block - Wikipedia

Comments Off on First-degree atrioventricular block – Wikipedia

Comparative genomic hybridization – Wikipedia

Posted: at 5:07 am

Comparative genomic hybridization (CGH) is a molecular cytogenetic method for analysing copy number variations (CNVs) relative to ploidy level in the DNA of a test sample compared to a reference sample, without the need for culturing cells. The aim of this technique is to quickly and efficiently compare two genomic DNA samples arising from two sources, which are most often closely related, because it is suspected that they contain differences in terms of either gains or losses of either whole chromosomes or subchromosomal regions (a portion of a whole chromosome). This technique was originally developed for the evaluation of the differences between the chromosomal complements of solid tumor and normal tissue,[1] and has an improved resolution of 510 megabases compared to the more traditional cytogenetic analysis techniques of giemsa banding and fluorescence in situ hybridization (FISH) which are limited by the resolution of the microscope utilized.[2][3]

This is achieved through the use of competitive fluorescence in situ hybridization. In short, this involves the isolation of DNA from the two sources to be compared, most commonly a test and reference source, independent labelling of each DNA sample with fluorophores (fluorescent molecules) of different colours (usually red and green), denaturation of the DNA so that it is single stranded, and the hybridization of the two resultant samples in a 1:1 ratio to a normal metaphase spread of chromosomes, to which the labelled DNA samples will bind at their locus of origin. Using a fluorescence microscope and computer software, the differentially coloured fluorescent signals are then compared along the length of each chromosome for identification of chromosomal differences between the two sources. A higher intensity of the test sample colour in a specific region of a chromosome indicates the gain of material of that region in the corresponding source sample, while a higher intensity of the reference sample colour indicates the loss of material in the test sample in that specific region. A neutral colour (yellow when the fluorophore labels are red and green) indicates no difference between the two samples in that location.[2][3]

CGH is only able to detect unbalanced chromosomal abnormalities. This is because balanced chromosomal abnormalities such as reciprocal translocations, inversions or ring chromosomes do not affect copy number, which is what is detected by CGH technologies. CGH does, however, allow for the exploration of all 46 human chromosomes in single test and the discovery of deletions and duplications, even on the microscopic scale which may lead to the identification of candidate genes to be further explored by other cytological techniques.[2]

Through the use of DNA microarrays in conjunction with CGH techniques, the more specific form of array CGH (aCGH) has been developed, allowing for a locus-by-locus measure of CNV with increased resolution as low as 100 kilobases.[4][5] This improved technique allows for the aetiology of known and unknown conditions to be discovered.

The motivation underlying the development of CGH stemmed from the fact that the available forms of cytogenetic analysis at the time (giemsa banding and FISH) were limited in their potential resolution by the microscopes necessary for interpretation of the results they provided. Furthermore, giemsa banding interpretation has the potential to be ambiguous and therefore has lowered reliability, and both techniques require high labour inputs which limits the loci which may be examined.[4]

The first report of CGH analysis was by Kallioniemi and colleagues in 1992 at the University of California, San Francisco, who utilised CGH in the analysis of solid tumors. They achieved this by the direct application of the technique to both breast cancer cell lines and primary bladder tumors in order to establish complete copy number karyotypes for the cells. They were able to identify 16 different regions of amplification, many of which were novel discoveries.[1]

Soon after in 1993, du Manoir et al. reported virtually the same methodology. The authors painted a series of individual human chromosomes from a DNA library with two different fluorophores in different proportions to test the technique, and also applied CGH to genomic DNA from patients affected with either Downs syndrome or T-cell prolymphocytic leukemia as well as cells of a renal papillary carcinoma cell line. It was concluded that the fluorescence ratios obtained were accurate and that differences between genomic DNA from different cell types were detectable, and therefore that CGH was a highly useful cytogenetic analysis tool.[6]

Initially, the widespread use of CGH technology was difficult, as protocols were not uniform and therefore inconsistencies arose, especially due to uncertainties in the interpretation of data.[3] However, in 1994 a review was published which described an easily understood protocol in detail[7] and the image analysis software was made available commercially, which allowed CGH to be utilised all around the world.[3]As new techniques such as microdissection and degenerate oligonucleotide primed polymerase chain reaction (DOP-PCR) became available for the generation of DNA products, it was possible to apply the concept of CGH to smaller chromosomal abnormalities, and thus the resolution of CGH was improved.[3]

The implementation of array CGH, whereby DNA microarrays are used instead of the traditional metaphase chromosome preparation, was pioneered by Solinas-Tolodo et al. in 1997 using tumor cells[8] and Pinkel et al. in 1998 by use of breast cancer cells.[9] This was made possible by the Human Genome Project which generated a library of cloned DNA fragments with known locations throughout the human genome, with these fragments being used as probes on the DNA microarray.[10] Now probes of various origins such as cDNA, genomic PCR products and bacterial artificial chromosomes (BACs) can be used on DNA microarrays which may contain up to 2 million probes.[10] Array CGH is automated, allows greater resolution (down to 100 kb) than traditional CGH as the probes are far smaller than metaphase preparations, requires smaller amounts of DNA, can be targeted to specific chromosomal regions if required and is ordered and therefore faster to analyse, making it far more adaptable to diagnostic uses.[10][11]

The DNA on the slide is a reference sample, and is thus obtained from a karyotypically normal man or woman, though it is preferential to use female DNA as they possess two X chromosomes which contain far more genetic information than the male Y chromosome. Phytohaemagglutinin stimulated peripheral blood lymphocytes are used. 1mL of heparinised blood is added to 10ml of culture medium and incubated for 72 hours at 37C in an atmosphere of 5% CO2. Colchicine is added to arrest the cells in mitosis, the cells are then harvested and treated with hypotonic potassium chloride and fixed in 3:1 methanol/acetic acid.[3]

One drop of the cell suspension should then be dropped onto an ethanol cleaned slide from a distance of about 30cm, optimally this should be carried out at room temperature at humidity levels of 6070%. Slides should be evaluated by visualisation using a phase contrast microscope, minimal cytoplasm should be observed and chromosomes should not be overlapping and be 400550 bands long with no separated chromatids and finally should appear dark rather than shiny. Slides then need to be air dried overnight at room temperature, and any further storage should be in groups of four at 20C with either silica beads or nitrogen present to maintain dryness. Different donors should be tested as hybridization may be variable. Commercially available slides may be used, but should always be tested first.[3]

Standard phenol extraction is used to obtain DNA from test or reference (karyotypically normal individual) tissue, which involves the combination of Tris-Ethylenediaminetetraacetic acid and phenol with aqueous DNA in equal amounts. This is followed by separation by agitation and centrifugation, after which the aqueous layer is removed and further treated using ether and finally ethanol precipitation is used to concentrate the DNA.[3]

May be completed using DNA isolation kits available commercially which are based on affinity columns.[3]

Preferentially, DNA should be extracted from fresh or frozen tissue as this will be of the highest quality, though it is now possible to use archival material which is formalin fixed or paraffin wax embedded, provided the appropriate procedures are followed. 0.5-1g of DNA is sufficient for the CGH experiment, though if the desired amount is not obtained DOP-PCR may be applied to amplify the DNA, however it in this case it is important to apply DOP-PCR to both the test and reference DNA samples to improve reliability.[3]

Nick translation is used to label the DNA and involves cutting DNA and substituting nucleotides labelled with fluorophores (direct labelling) or biotin or oxigenin to have fluophore conjugated antibodies added later (indirect labelling). It is then important to check fragment lengths of both test and reference DNA by gel electrophoresis, as they should be within the range of 500kb-1500kb for optimum hybridization.[3]

Unlabelled Life Technologies Corporation's Cot-1 DNA (placental DNA enriched with repetitive sequences of length 50bp-100bp)is added to block normal repetitive DNA sequences, particularly at centromeres and telomeres, as these sequences, if detected, may reduce the fluorescence ratio and cause gains or losses to escape detection.[3]

812l of each of labelled test and labelled reference DNA are mixed and 40g Cot-1 DNA is added, then precipitated and subsequently dissolved in 6l of hybridization mix, which contains 50% formamide to decrease DNA melting temperature and 10% dextran sulphate to increase the effective probe concentration in a saline sodium citrate (SSC) solution at a pH of 7.0.[3]

Denaturation of the slide and probes are carried out separately. The slide is submerged in 70% formamide/2xSSC for 510 minutes at 72C, while the probes are denatured by immersion in a water bath of 80C for 10 minutes and are immediately added to the metaphase slide preparation. This reaction is then covered with a coverslip and left for two to four days in a humid chamber at 40C.[3]

The coverslip is then removed and 5 minute washes are applied, three using 2xSSC at room temperature, one at 45C with 0.1xSSC and one using TNT at room temperature. The reaction is then preincubated for 10 minutes then followed by a 60-minute, 37C incubation, three more 5 minute washes with TNT then one with 2xSSC at room temperature. The slide is then dried using an ethanol series of 70%/96%/100% before counterstaining with DAPI (0.35 g/ml), for chromosome identification, and sealing with a coverslip.[3]

A fluorescence microscope with the appropriate filters for the DAPI stain as well as the two fluorophores utilised is required for visualisation, and these filters should also minimise the crosstalk between the fluorophores, such as narrow band pass filters. The microscope must provide uniform illumination without chromatic variation, be appropriately aligned and have a "plan" type of objective which is apochromatic and give a magnification of x63 or x100.[3]

The image should be recorded using a camera with spatial resolution at least 0.1m at the specimen level and give an image of at least 600x600 pixels. The camera must also be able to integrate the image for at least 5 to 10 seconds, with a minimum photometric resolution of 8 bit.[3]

Dedicated CGH software is commercially available for the image processing step, and is required to subtract background noise, remove and segment materials not of chromosomal origin, normalize the fluorescence ratio, carry out interactive karyotyping and chromosome scaling to standard length. A "relative copy number karyotype" which presents chromosomal areas of deletions or amplifications is generated by averaging the ratios of a number of high quality metaphases and plotting them along an ideogram, a diagram identifying chromosomes based on banding patterns. Interpretation of the ratio profiles is conducted either using fixed or statistical thresholds (confidence intervals). When using confidence intervals, gains or losses are identified when 95% of the fluorescence ratio does not contain 1.0.[3]

Extreme care must be taken to avoid contamination of any step involving DNA, especially with the test DNA as contamination of the sample with normal DNA will skew results closer to 1.0, thus abnormalities may go undetected. FISH, PCR and flow cytometry experiments may be employed to confirm results.[4][12]

Array comparative genomic hybridization (also microarray-based comparative genomic hybridization, matrix CGH, array CGH, aCGH) is a molecular cytogenetic technique for the detection of chromosomal copy number changes on a genome wide and high-resolution scale.[13] Array CGH compares the patient's genome against a reference genome and identifies differences between the two genomes, and hence locates regions of genomic imbalances in the patient, utilizing the same principles of competitive fluorescence in situ hybridization as traditional CGH.

With the introduction of array CGH, the main limitation of conventional CGH, a low resolution, is overcome. In array CGH, the metaphase chromosomes are replaced by cloned DNA fragments (+100200 kb) of which the exact chromosomal location is known. This allows the detection of aberrations in more detail and, moreover, makes it possible to map the changes directly onto the genomic sequence.[14]

Array CGH has proven to be a specific, sensitive, fast and highthroughput technique, with considerable advantages compared to other methods used for the analysis of DNA copy number changes making it more amenable to diagnostic applications. Using this method, copy number changes at a level of 510 kilobases of DNA sequences can be detected.[15] As of 2006[update], even high-resolution CGH (HR-CGH) arrays are accurate to detect structural variations (SV) at resolution of 200 bp.[16] This method allows one to identify new recurrent chromosome changes such as microdeletions and duplications in human conditions such as cancer and birth defects due to chromosome aberrations.

Array CGH is based on the same principle as conventional CGH. In both techniques, DNA from a reference (or control) sample and DNA from a test (or patient) sample are differentially labelled with two different fluorophores and used as probes that are cohybridized competitively onto nucleic acid targets. In conventional CGH, the target is a reference metaphase spread. In array CGH, these targets can be genomic fragments cloned in a variety of vectors (such as BACs or plasmids), cDNAs, or oligonucleotides.[17]

Figure 2.[14] is a schematic overview of the array CGH technique. DNA from the sample to be tested is labeled with a red fluorophore (Cyanine 5) and a reference DNA sample is labeled with green fluorophore (Cyanine 3). Equal quantities of the two DNA samples are mixed and cohybridized to a DNA microarray of several thousand evenly spaced cloned DNA fragments or oligonucleotides, which have been spotted in triplicate on the array. After hybridization, digital imaging systems are used to capture and quantify the relative fluorescence intensities of each of the hybridized fluorophores.[17] The resulting ratio of the fluorescence intensities is proportional to the ratio of the copy numbers of DNA sequences in the test and reference genomes. If the intensities of the flurochromes are equal on one probe, this region of the patient's genome is interpreted as having equal quantity of DNA in the test and reference samples; if there is an altered Cy3:Cy5 ratio this indicates a loss or a gain of the patient DNA at that specific genomic region.[18]

Array CGH has been implemented using a wide variety of techniques. Therefore, some of the advantages and limitations of array CGH are dependent on the technique chosen.The initial approaches used arrays produced from large insert genomic DNA clones, such as BACs. The use of BACs provides sufficient intense signals to detect single-copy changes and to locate aberration boundaries accurately. However, initial DNA yields of isolated BAC clones are low and DNA amplification techniques are necessary. These techniques include ligation-mediated polymerase chain reaction (PCR), degenerate primer PCR using one or several sets of primers, and rolling circle amplification.[19] Arrays can also be constructed using cDNA. These arrays currently yield a high spatial resolution, but the number of cDNAs is limited by the genes that are encoded on the chromosomes, and their sensitivity is low due to cross-hybridization.[14] This results in the inability to detect single copy changes on a genome wide scale.[20] The latest approach is spotting the arrays with short oligonucleotides. The amount of oligos is almost infinite, and the processing is rapid, cost-effective, and easy. Although oligonucleotides do not have the sensitivity to detect single copy changes, averaging of ratios from oligos that map next to each other on the chromosome can compensate for the reduced sensitivity.[21] It is also possible to use arrays which have overlapping probes so that specific breakpoints may be uncovered.

There are two approaches to the design of microarrays for CGH applications: whole genome and targeted.

Whole genome arrays are designed to cover the entire human genome. They often include clones that provide an extensive coverage across the genome; and arrays that have contiguous coverage, within the limits of the genome. Whole-genome arrays have been constructed mostly for research applications and have proven their outstanding worth in gene discovery. They are also very valuable in screening the genome for DNA gains and losses at an unprecedented resolution.[17]

Targeted arrays are designed for a specific region(s) of the genome for the purpose of evaluating that targeted segment. It may be designed to study a specific chromosome or chromosomal segment or to identify and evaluate specific DNA dosage abnormalities in individuals with suspected microdeletion syndromes or subtelomeric rearrangements. The crucial goal of a targeted microarray in medical practice is to provide clinically useful results for diagnosis, genetic counseling, prognosis, and clinical management of unbalanced cytogenetic abnormalities.[17]

Conventional CGH has been used mainly for the identification of chromosomal regions that are recurrently lost or gained in tumors, as well as for the diagnosis and prognosis of cancer.[22] This approach can also be used to study chromosomal aberrations in fetal and neonatal genomes. Furthermore, conventional CGH can be used in detecting chromosomal abnormalities and have been shown to be efficient in diagnosing complex abnormalities associated with human genetic disorders.[14]

CGH data from several studies of the same tumor type show consistent patterns of non-random genetic aberrations.[23] Some of these changes appear to be common to various kinds of malignant tumors, while others are more tumor specific. For example, gains of chromosomal regions lq, 3q and 8q, as well as losses of 8p, 13q, 16q and 17p, are common to a number of tumor types, such as breast, ovarian, prostate, renal and bladder cancer (Figure. 3). Other alterations, such as 12p and Xp gains in testicular cancer, 13q gain 9q loss in bladder cancer, 14q loss in renal cancer and Xp loss in ovarian cancer are more specific, and might reflect the unique selection forces operating during cancer development in different organs.[23] Array CGH is also frequently used in research and diagnostics of B cell malignancies, such as chronic lymphocytic leukemia.

Cri du Chat (CdC) is a syndrome caused by a partial deletion of the short arm of chromosome 5.[24] Several studies have shown that conventional CGH is suitable to detect the deletion, as well as more complex chromosomal alterations. For example, Levy et al. (2002) reported an infant with a cat-like cry, the hallmark of CdC, but having an indistinct karyotype. CGH analysis revealed a loss of chromosomal material from 5p15.3 confirming the diagnosis clinically. These results demonstrate that conventional CGH is a reliable technique in detecting structural aberrations and, in specific cases, may be more efficient in diagnosing complex abnormalities.[24]

Array CGH applications are mainly directed at detecting genomic abnormalities in cancer. However, array CGH is also suitable for the analysis of DNA copy number aberrations that cause human genetic disorders.[14] That is, array CGH is employed to uncover deletions, amplifications, breakpoints and ploidy abnormalities. Earlier diagnosis is of benefit to the patient as they may undergo appropriate treatments and counseling to improve their prognosis.[10]

Genetic alterations and rearrangements occur frequently in cancer and contribute to its pathogenesis. Detecting these aberrations by array CGH provides information on the locations of important cancer genes and can have clinical use in diagnosis, cancer classification and prognostification.[17] However, not all of the losses of genetic material are pathogenetic, since some DNA material is physiologically lost during the rearrangement of immunoglobulin subgenes. In a recent study, array CGH has been implemented to identify regions of chromosomal aberration (copy-number variation) in several mouse models of breast cancer, leading to identification of cooperating genes during myc-induced oncogenesis.[25]

Array CGH may also be applied not only to the discovery of chromosomal abnormalities in cancer, but also to the monitoring of the progression of tumors. Differentiation between metastatic and mild lesions is also possible using FISH once the abnormalities have been identified by array CGH.[5][10]

PraderWilli syndrome (PWS) is a paternal structural abnormality involving 15q11-13, while a maternal aberration in the same region causes Angelman syndrome (AS). In both syndromes, the majority of cases (75%) are the result of a 35 Mb deletion of the PWS/AS critical region.[26] These small aberrations cannot be detected using cytogenetics or conventional CGH, but can be readily detected using array CGH. As a proof of principle Vissers et al. (2003) constructed a genome wide array with a 1 Mb resolution to screen three patients with known, FISH-confirmed microdeletion syndromes, including one with PWS. In all three cases, the abnormalities, ranging from 1.5 to 2.9Mb, were readily identified.[27] Thus, array CGH was demonstrated to be a specific and sensitive approach in detecting submicroscopic aberrations.

When using overlapping microarrays, it is also possible to uncover breakpoints involved in chromosomal aberrations.

Though not yet a widely employed technique, the use of array CGH as a tool for preimplantation genetic screening is becoming an increasingly popular concept. It has the potential to detect CNVs and aneuploidy in eggs, sperm or embryos which may contribute to failure of the embryo to successfully implant, miscarriage or conditions such as Down syndrome (trisomy 21). This makes array CGH a promising tool to reduce the incidence of life altering conditions and improve success rates of IVF attempts. The technique involves whole genome amplification from a single cell which is then used in the array CGH method. It may also be used in couples carrying chromosomal translocations such as balanced reciprocal translocations or Robertsonian translocations, which have the potential to cause chromosomal imbalances in their offspring.[12][28][29]

A main disadvantage of conventional CGH is its inability to detect structural chromosomal aberrations without copy number changes, such as mosaicism, balanced chromosomal translocations, and inversions. CGH can also only detect gains and losses relative to the ploidy level.[30] In addition, chromosomal regions with short repetitive DNA sequences are highly variable between individuals and can interfere with CGH analysis.[14] Therefore, repetitive DNA regions like centromeres and telomeres need to be blocked with unlabeled repetitive DNA (e.g. Cot1 DNA) and/or can be omitted from screening.[31] Furthermore, the resolution of conventional CGH is a major practical problem that limits its clinical applications. Although CGH has proven to be a useful and reliable technique in the research and diagnostics of both cancer and human genetic disorders, the applications involve only gross abnormalities. Because of the limited resolution of metaphase chromosomes, aberrations smaller than 510 Mb cannot be detected using conventional CGH.[23]For the detection of such abnormalities, a high-resolution technique is required.Array CGH overcomes many of these limitations. Array CGH is characterized by a high resolution, its major advantage with respect to conventional CGH. The standard resolution varies between 1 and 5 Mb, but can be increased up to approximately 40 kb by supplementing the array with extra clones. However, as in conventional CGH, the main disadvantage of array CGH is its inability to detect aberrations that do not result in copy number changes and is limited in its ability to detect mosaicism.[14] The level of mosaicism that can be detected is dependent on the sensitivity and spatial resolution of the clones. At present, rearrangements present in approximately 50% of the cells is the detection limit. For the detection of such abnormalities, other techniques, such as SKY (Spectral karyotyping) or FISH have to still be used.[32]

Original post:

Comparative genomic hybridization - Wikipedia

Comments Off on Comparative genomic hybridization – Wikipedia