Daily Archives: November 23, 2022

3576 – Gene ResultCXCL8 C-X-C motif chemokine ligand 8 [ (human)]

Posted: November 23, 2022 at 5:04 am

Envelope surface glycoprotein gp120 env HIV-1 CN54, JRFL, and Ada Env (gp120) upregulates IL-6, CCL2, CCL4, CXCL8, and IL-1b through TLR4 and CCR5 induction in monocyte derived macrophages and hepatic stellate cells because treatment with an anti-TLR4 antibody mitigated the response PubMed env HIV-1 JRFL Env (gp120) upregulates IL8 in ARPE-19 cells PubMed env HIV-1 ADA infection decreases production of CXCL8 (IL8), CCL2 (MCP-1), and IL6 at a basal level or after Fc receptor, complement receptor 3, or bacterial stimulation in primary human macrophages PubMed env HIV-1 IIIB Env (gp120) upregulates production of TNF (TNF-a), IL-17A, CCL2 (MCP1), CCL5 (RANTES), IL6, IL10, CXCL8 (IL8), CXCL1 (GRO-a), and CCL1 (I309) in stimulated monocyte derived macrophages PubMed env Interleukin 8 (IL-8) gene expression is enhanced in monocytes treated with HIV-1 gp120 PubMed env Curcumin, a potent and safe anti-inflammatory compound, inhibits HIV-1 gp120-mediated upregulation of the proinflammatory cytokines TNF-alpha and IL-6, and the chemokines IL-8, RANTES, and IP-10 in primary human genital epithelial cells PubMed env HIV-1 gp120 upregulates the expression of interleukin 8 (IL8) in human B cells PubMed env HIV-1 gp120 upregulates the expression of IL-6 and IL-8 via the p38 signaling pathway and the PI3K/Akt signaling pathway in astrocytes PubMed env The binding of soluble HIV-1 gp120 to TLR2 or TLR4 results in upregulation of the TNF-alpha and IL-8 production through NF-kappaB activation PubMed env HIV-1 gp120-mediated increases in IL-8 production in astrocytes are mediated through the NF-KappaB pathway PubMed env In endometrial epithelium-derived cells, gp120 from CCR5-tropic HIV-1 increases the release of monocytes/chemokines-attracting chemokines (IL-8 and GRO) and proinflammatory cytokines (TNF-beta and IL-1alpha) PubMed Envelope transmembrane glycoprotein gp41 env The binding of soluble TLR2 to HIV-1 MA, CA, or gp41 inhibits the nuclear translocation of NFKB p65 subunit and downregulates CXCL8 (IL-8) and CCR5 expression, leading to inhibition of HIV-1 infection in cells PubMed env Evidence suggests HIV CA (p24) binds TLR2 and blocks activation by HIV MA (p17) and/or gp41 BUT DOES NOT block activation via Pam3CSK4 suggesting that HIV manipulates innate immune signaling through a TLR2-dependent mechanism PubMed env Exposure of TZM-bl 2 cells to CA (p24) for 1h prior to HIV gp41 decreases CXCL8 (IL-8) production yet has little to no effect on the inhibition of Pam3CSK4 (a synthetic bacterial TLR2/1 ligand) production of CXCL8 (IL-8) PubMed env Exposure of human T cells to HIV gp41 increases extracellular CXCL8 (IL-8) levels but to a lesser extent than CA (p24) and gp41 PubMed env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 inhibits activation of PBMCs and upregulates the expression of IL-8 in peptide-treated PBMCs PubMed env The interaction between HIV-1 gp41 fusion peptide and lymphocyte membrane is blocked by interleukin-8 and abolished by pre-treating the cells with heparin sulfate (HS) PubMed Nef nef HIV-1 Nef induces IL6 and CXCL8 (IL8) expression in a PIK3-PKC dependent, AKT independent manner PubMed nef HIV-1 Nef induces IL6 and IL8 expression through the NF-kappaB pathway PubMed nef HIV-1 Nef treatment induces IL6 and IL8 production in SVGA cells and primary human fetal astrocytes PubMed nef HIV-1 Tat and Nef combination treatment induces release of both IL-6 and IL-8 in human mesenchymal stem cells PubMed nef HIV-1 Nef expression by immature human and macaque dendritic cells (DCs) upregulates IL-6, IL-12, TNF-alpha, CXCL8, CCL3, and CCL4 release, but without upregulating co-stimulatory and other molecules characteristic of mature DCs PubMed Pr55(Gag) gag MVA-gag induces a significant release of cytokines such as IL-2R, IL-6, IL-8, TNF-alpha, IFN-gamma, MCP-1, MIP-1alpha, MIP-1beta, and RANTES by the infected monocyte-derived dendritic cells in comparison with uninfected cells PubMed Tat tat HIV-1 Tat upregulates CXCL8 mRNA and protein expression in CRT-MG human astroglioma cells PubMed tat HIV-1 Tat upregulates (CXCL8) IL8 protein expression in human monocytes and monocyte-derived dendritic cells in a TLR4-CD14-MD2 dependent manner PubMed tat HIV-1 Tat and Nef combination treatment induces release of both IL-6 and IL-8 in human mesenchymal stem cells PubMed tat HIV-1 Tat-induced upregulation of IL-8 in a time-dependent manner involves NF-kappaB and AP-1 transcription factors, activation of the p38 MAPK beta subunit, and PI3K/Akt pathway in astrocytes PubMed tat HIV-1 Tat upregulates IL-8 expression in astrocytes, monocytes, monocyte derived macrophages, Jurkat T-cells, HeLa cells, and human brain endothelial cells, an effect that likely contributes to the immune dysregulation observed during HIV-1 infection PubMed tat HIV-1 Tat downregulates the expression of adiponectin protein and upregulates the expression of IL-6, IL-8, and MCP-1 proteins in human SGBS preadipocytes PubMed tat HIV-1 Tat protein upregulates expression of IL-6 and IL-8 in human breast cancer cells by an NF-kappaB-dependent pathway PubMed tat HIV-1 Tat upregulates IL-8 and VEGF production and release from polymorphonuclear leukocytes (PMNL), indicating that PMNL recruitment by Tat is linked to angiogenesis PubMed tat HIV-1 Tat upregulation of IL-8 is linked to the cell cycle and involves NF-kappa B, RelA, c-rel, and CREB-binding protein PubMed tat Upregulation of IL-8 by HIV-1 Tat is implicated in the pathogenesis of Kaposi's sarcoma PubMed tat HIV-1 Tat downregulates IL-8 expression in the Raji B-cell line, however in the presence of PMA+PHA Tat induced IL-8 expression PubMed tat Upregulation of IL-8 by HIV-1 Tat in astrocytes is inhibited by the MEK1/2 inhibitor UO126, indicating a role for MEK1/2 in Tat-mediated chemokine induction PubMed Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr upregulates secretion of IL6, CXCL8 (IL8), MCP-1, and MIF and downregulates secretion of serpin E1, a serine proteinase inhibitor (known as PAI-1) PubMed vpr HIV-1 Vpr downregulates the expression of IL8 in human monocyte-derived dendritic cells PubMed vpr HIV-1 Vpr induced upregulation of CXCL8 (IL8) involves PI3K/Akt mediated activation of NFKB1 (NF-kappa-B) in astrocytes PubMed vpr HIV-1 Vpr-mediated upregulation of CXCL8 (IL8) involves NFKB1 (NF-kappa-B) PubMed vpr HIV-1 Vpr enhances the secretion of CXCL8 (IL8) from human fetal astrocytes PubMed vpr HIV-1 Vpr upregulates the expression of CXCL8 (IL8) mRNA in human fetal astrocytes PubMed vpr HIV-1 Vpr upregulates the expression fo CXCL8 (IL8) mRNA in SVGA in a dose-dependent manner PubMed vpr HIV-1 Vpr upregulates the expression of CXCL8 (IL8) mRNA in SVGA astrocytes in a time dependent fashion PubMed vpr HIV-1 Vpr enhances the secretion of CXCL8 (IL8) from SVGA astrocytes in a time dependent fashion PubMed vpr HIV-1 involves the JUN (AP-1) transcription factor in the induction of CXCL8 (IL8) in astrocytes PubMed vpr HIV-1 Vpr involves the CEBPD (C/EBP-delta) transcription factor in the induction of CXCL8 (IL8) in astrocytes PubMed vpr Vpr-mediated upregulation of CXCL8 (IL8) involves MAPK8 (JnK-MAPK) in astrocytes PubMed vpr Vpr-mediated upregulation of CXCL8 (IL8) in astrocytes involves p38-MAPK11 (beta isoform of p38-MAPK) PubMed vpr HIV-1 Vpr regulates interleukin 8 (CXCL8 (IL8)) expression, with reports showing both up- and downregulation of CXCL8 (IL8) PubMed capsid gag CXCL8-induced upregulation of HIV-1 p24 levels and 2-LTR circles is inhibited by CXCR1 or CXCR2 neutralization in HIV-1-infected monocytes-derived macrophages PubMed gag The binding of soluble TLR2 to HIV-1 MA, CA, or gp41 inhibits the nuclear translocation of NFKB p65 subunit and downregulates CXCL8 (IL-8) and CCR5 expression, leading to inhibition of HIV-1 infection in cells PubMed gag Treatment with chemokine CXCL8 significantly upregulates HIV-1 CA (p24) levels in supernatants of both HIV-1-infected monocytes-derived macrophages as well as microglia in a dose-dependent manner PubMed gag Evidence suggests HIV CA (p24) binds TLR2 and blocks activation by HIV MA (p17) and/or gp41 BUT DOES NOT block activation via Pam3CSK4 suggesting that HIV manipulates innate immune signaling through a TLR2-dependent mechanism PubMed gag Simultaneous exposure of TZM-bl2 cells with HIV CA(p24) and MA (p17) decreases MA (p17)- induced production of CXCL8 (IL-8) in a dose-dependent manner PubMed gag Exposure of TZM-bl 2 cells to CA(p24) for 1h prior to HIV gp41 or MA (p17) decreases CXCL8 (IL-8) production yet has little to no effect on the inhibition of Pam3CSK4 (a synthetic bacterial TLR2/1 ligand) production of CXCL8 (IL-8) PubMed gag Exposure of human T cells to HIV CA (p24) increases extracellular CXCL8 (IL-8) levels in a dose dependent manner and to a greater extent than gp41 but to a lesser extent than MA (p17) exposures. PubMed gag PLA-p24-loaded human monocyte-derived dendritic cells enhance the secretion of MIP-1beta, IL-6, IL-8, and TNF-alpha in comparison with PLA-loaded cells alone PubMed integrase gag-pol The formation of 2-long terminal repeat circles, a measure of viral genome integration, is higher in CXCL8-treated, HIV-1-infected monocytes-derived macrophages and microglia, suggesting the interaction between HIV-1 IN and CXCL8 PubMed gag-pol IL-8 decreases HIV-1 reverse transcription and viral integration during the early infection, suggesting the interaction between HIV-1 IN and IL-8 PubMed matrix gag Evidence suggests HIV CA (p24) binds TLR2 and blocks activation by HIV MA (p17) and/or gp41 BUT DOES NOT block activation via Pam3CSK4 suggesting that HIV manipulates innate immune signaling through a TLR2-dependent mechanism PubMed gag Simultaneous exposure of TZM-bl2 cells with HIV CA(p24) and MA (p17) decreases MA (p17)- induced production of CXCL8 (IL-8) in a dose-dependent manner PubMed gag Exposure of TZM-bl 2 cells to CA(p24) for 1h prior to HIV MA(p17) decreases CXCL8 (IL-8) production yet has little to no effect on the inhibition of Pam3CSK4 (a synthetic bacterial TLR2/1 ligand) production of CXCL8 (IL-8) PubMed gag Exposure of human T cells to HIV MA (p17) increases extracellular CXCL8 (IL-8) levels in a dose dependent manner and to a greater extent than CA (p24) and gp41. PubMed gag The binding of soluble TLR2 to HIV-1 MA, CA, or gp41 inhibits the nuclear translocation of NFKB p65 subunit and downregulates IL-8 and CCR5 expression, leading to inhibition of HIV-1 infection in cells PubMed gag Surface plasmon resonance analysis reveals that HIV-1 p17 binds IL-8 PubMed nucleocapsid gag HIV-1 NC upregulates IL8 in HEK 293T cells PubMed reverse transcriptase gag-pol IL-8 decreases HIV-1 reverse transcription and viral integration during the early infection, suggesting the interaction between HIV-1 RT and IL-8 PubMed

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3576 - Gene ResultCXCL8 C-X-C motif chemokine ligand 8 [ (human)]

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Tom Brady, Steph Curry and others face a widening securities investigation over FTX crypto fraud – Yahoo Sports

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Tom Brady, Steph Curry and others face a widening securities investigation over FTX crypto fraud  Yahoo Sports

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The peak 49ers team finally showed up in a win over the Cardinals, and it was impressive – Yahoo Sports

Posted: at 5:02 am

The peak 49ers team finally showed up in a win over the Cardinals, and it was impressive  Yahoo Sports

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The peak 49ers team finally showed up in a win over the Cardinals, and it was impressive - Yahoo Sports

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Elon Musk has himself to blame for Twitter’s advertising woes, civil rights groups say – CNBC

Posted: at 5:01 am

  1. Elon Musk has himself to blame for Twitter's advertising woes, civil rights groups say  CNBC
  2. Elon Musks free speech agenda dismantles Twitter's ability to police content  The Washington Post
  3. Elon Musk never cared if Twitter was a business failure he wants a political win  The Guardian
  4. The only constant at Elon Musk's Twitter is chaos  The Verge
  5. Elon Musk's revival of Trump's Twitter account shows his political mission  MSNBC
  6. View Full Coverage on Google News

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Elon Musk has himself to blame for Twitter's advertising woes, civil rights groups say - CNBC

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Genome Insight and Kun-hee Lee Child Cancer & Rare Disease Project Team of SNUH (Seoul National University Hospital) Made an Agreement About a…

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Genome Insight and Kun-hee Lee Child Cancer & Rare Disease Project Team of SNUH (Seoul National University Hospital) Made an Agreement About a Pediatric Cancer Whole Genome Collaborative Study  Business Wire

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Rationalism vs. Empiricism | Concepts, Differences & Examples – Video …

Posted: at 4:58 am

The difference between rationalism and empiricism can be understood primarily in terms of three claims on which the positions disagree. The first claim is the intuition/deduction thesis. This is the idea that people can gain knowledge just by using intuition, and by building off their intuition with deductive reasoning. Empiricists generally only agree with this thesis in the case of knowledge that concerns ideas, and not knowledge concerning the external world. Rationalists, on the other hand, often claim that people can gain meaningful knowledge about the external world through intuition and deduction.

The second claim is the innate knowledge thesis. Similar to innate concepts, innate knowledge is the idea that it is simply part of human nature to know certain facts about the world, without having to learn them. The difference between a fact known through intuition and one known innately is that intuitively known facts are felt or sensed to be true when someone thinks about them, whereas innate knowledge is simply known to be true. Rationalists often identify particular claims that they believe are examples of innate knowledge. Empiricists generally hold that innate knowledge does not exist, as such a claim would go against the concept of the blank slate. Empiricists may hold that people have certain innate capacities that allow them to learn, but the knowledge itself must be the product of experience.

The third claim is the innate concept thesis. Like innate knowledge, an innate concept is one that exists within the human mind without a person having learned it. Innate concepts are different from innate knowledge because having a concept in one's mind just means understanding the meaning of some idea; it does not involve knowing a fact or statement. Rationalists often claim that people understand certain ideas innately, such as the idea of free will, or of mind and body. However, as in the case of innate knowledge, empiricists generally hold that innate concepts do not exist, because people are born as blank slates.

Although rationalism and empiricism generally advocate different views about the source of knowledge, it is not accurate to think of them as opposite positions or to view them as two binary options. Many philosophers who have been considered rationalists or empiricists actually have more complexity in their positions, and a given philosopher might follow rationalist principles in one field but empiricist principles in another.

Furthermore, rationalism and empiricism do not necessarily lead to opposing conclusions or viewpoints. For example, both rationalism and empiricism employ skepticism in their arguments. Descartes, who is generally viewed as a rationalist philosopher, argued for the importance of doubting apparent sources of knowledge and examining whether it is possible to have certainty about anything. This skeptical method was shared by empiricist philosophers such as David Hume, who examined whether the information people gain from experience is actually enough to justify knowledge about the world.

Another related shared idea is the emphasis on one's own individual perspective as the source of knowledge. According to Descartes's skeptical method, knowledge can only be gained by beginning with certainty about the existence of one's own mind. This is the source of his famous argument that ''I think, therefore I am,'' often called the cogito. The cogito claims that a person can be certain that they exist because they are thinking. This idea is linked to solipsism, the claim that other people do not truly exist or do not have minds. Descartes argues that external experience should be doubted, but ultimately claims that it is possible to gain knowledge of the outside world. Locke, who is generally viewed as an empiricist, takes up a similar idea and questions whether it is possible to know that other people think and feel. His conclusion is that there is no way to directly know that other people have minds, but that it is a reasonable inference based on observations of the world.

Rationalism and empiricism are terms used to describe different views about where people acquire knowledge. They are part of the field of epistemology, which examines the meaning, origin, and scope of knowledge. Rationalism views reason and intuition, or people's ability to sense the truth of statements, to be key ways of gaining knowledge. Rationalism focuses on deduction, or using the laws of logic to make arguments featuring conclusions that must be true. It also advocates the existence of innate ideas that people inherently possess in their minds. Empiricism, by contrast, holds that ideas and knowledge are the result of sense experience, or people's sensory interactions with the world. According to empiricism, the mind at birth is a tabula rasa or blank slate, without any knowledge or ideas. Knowledge is gained through induction, where people use experiences to make plausible inferences about the world.

Rationalism and empiricism can be distinguished based on three central claims. First is the intuition/deduction thesis: Rationalists generally consider intuition and deduction to be legitimate avenues to meaningful knowledge concerning the external world, whereas empiricists think intuition is only reliable when it comes to claims about ideas and their meaning. Next is the innate knowledge thesis: Rationalists often claim people have innate knowledge residing in their minds, whereas empiricists generally claim experience is where people get knowledge. Third is the innate concept thesis: Rationalists generally think people innately understand certain concepts, whereas empiricists disagree. Despite these disagreements, rationalism and empiricism are not truly opposing views. Many philosophers have views that incorporate both positions. There are also some issues where rationalists and empiricists take a similar approach. For instance, both rationalist and empiricist philosophers have advocated skepticism or doubt about apparent knowledge, and both have considered the issue of solipsism, or whether people can determine from their own experiences that other people exist and have minds of their own.

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Rationalist Judaism: Anti-Rationalism and the Charedi Vote

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In the charedi community, there is a carefully-crafted non-rationalist worldview about bitachon and hishtadlus. It was relentlessly drilled into me during my years in charedi yeshivos that all hishtadlus is meaningless. God directly controls everything, and the laws of nature have no power. The only reason why the world seems to run according to various laws is that otherwise there would be no free will. Hishtadlus is just a price that we pay to keep that illusion going, but it doesn't actually accomplish anything. And to the extent that we recognize that, it's possible to cut down on the hishtadlus.

Supposedly, this is a major reason why many charedim don't serve in the army or gain a secular education and work for a living. To the extent that you realize that Hashem directly runs everything, you don't need to engage in the sham of hishtadlus. On the contrary - it is learning Torah which provides divine protection from our enemies, which protects us from illness, which merits our parnasa.

The divide between the rationalist and anti-rationalist approaches to theology has fascinating ramifications with regard to the electoral system.

Rav Kornfeld is a local charedi rabbinic leader in Ramat Beit Shemesh who is not afraid to openly state the Israeli charedi perspective on such matters. For example, a few elections ago, he went on record in HaModia as stating that American olim are mistaken in believing that they have the right to choose who to vote for; instead, they are obligated to vote for whoever the Charedi-Litvishe-Non-RavShmuelAuerbach camp tell them to vote for. I am very grateful to Rav Elimelech Kornfeld for spelling out the ramifications of the charedi approach with regard to the electoral process. (I say that without any sarcasm; while I disagree with the anti-rationalist approach, I think that it's important for it to be articulated and I greatly appreciate his doing so.)

For this election, Rav Kornfeld gave a speech in his shul, reiterating the contents of a letter that he once printed on the front page of a local newspaper in a previous election, in which he spelled out the charedi anti-rationalist approach with regard to the very nature of the electoral system. In that letter, he explains that it is not in the hands of any politician or party to actually do anything for us, and continues as follows:

In other words, the entire system of voting in politicians who make policies that are implemented is, like all other forms of hishtadlus, is a sham; it's merely a cover, a mask for the workings of Hashem. However, it is very important to show support for the party that espouses Torah values (which he believes to be UTJ, notwithstanding how its MK was forced to resign for corruptly manipulating his power to protect a pedophile), because that will earn us the Divine favor which actually accomplishes everything that happens.

This appears to be an ingenious way of arriving at the same end result - vote for party x - while basing it on a fundamentally different idea about what voting actually accomplishes. However, the more one thinks through its ramifications, the more complications and problems arise.

First of all, it means that rallying votes is only important insofar as it shows Hashem that (charedi) Torah is important to us. But surely one can show Hashem that Torah is important even more powerfully by actually learning Torah! Are the two yeshivah boys who stayed in the Chevron Beis HaMidrash to learn while all their peers spent several hours traveling to and from Bnei Brak not showing Hashem that learning Torah is of supreme value to them?!

Second, it means that if people cheat (from either side), that will have absolutely no effect on the fate of the Jewish People. But why, then, is UTJ searching for people to monitor the voting booths?

Fourth, it means that if charedim are unsuccessful, then that is also from Hashem (and presumably as a result of their not sufficiently demonstrating their dedication to Him). So why, after Lapid's success in the last election and his resultant policies, was their so much anger towards him? Lapid didn't actually do anything, it was all from Hashem!

Fifth, it means that the followers of Rav Shmuel Auerbach and others, who are of the view that one should not participate in elections at all, are not doing any harm. After all, they are certainly acting out of dedication to Torah and Gedolim. So why is UTJ so upset about them?

Of course, nobody in the charedi world actually acts as though they think this way. When you look at all the vast effort expended to get charedim to vote, and the tremendous passion about who actually gets in the government, obviously charedim feel that the votes and politicians inherently make a difference. It's similar to the anti-rationalist notion that yeshivah students provide protection from rockets, and that parnassah is all in the hands of Hashem and has nothing to do with hishtadlus; people might profess to believe it, but when push comes to shove, nobody really believes it. After all, there is the awkward fact that on Rosh HaShanah, Hashem apparently decrees much more parnassah overall for people who engage in hishtadlus!

I wish people would just make up their minds and be consistent. Either you accept that hishtadlus has genuine significance - in which case, give your kids the education that they need to earn a living and maintain the economy, and stop ruling out army service for your community. Or, decide that hishtadlus has no real significance - in which case, stop with all the political stuff, and don't bother voting, just learn Torah!

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Age of Enlightenment – Wikipedia

Posted: at 4:58 am

European cultural movement of the 17th and 18th centuries

The Age of Enlightenment or the Enlightenment[note 2] was an intellectual and philosophical movement that dominated Europe in the 17th and 18th centuries with global influences and effects.[2][3] The Enlightenment included a range of ideas centered on the value of human happiness, the pursuit of knowledge obtained by means of reason and the evidence of the senses, and ideals such as liberty, progress, toleration, fraternity, and constitutional government.

The Enlightenment was preceded by the Scientific Revolution and the work of Francis Bacon, John Locke, and others. Some date the beginning of the Enlightenment to the publication of Ren Descartes' Discourse on the Method in 1637, featuring his famous dictum, Cogito, ergo sum ("I think, therefore I am"). Others cite the publication of Isaac Newton's Principia Mathematica (1687) as the culmination of the Scientific Revolution and the beginning of the Enlightenment. European historians traditionally date its beginning with the death of Louis XIV of France in 1715 and its end with the 1789 outbreak of the French Revolution. Many historians now date the end of the Enlightenment as the start of the 19th century, with the latest proposed year being the death of Immanuel Kant in 1804.

Philosophers and scientists of the period widely circulated their ideas through meetings at scientific academies, Masonic lodges, literary salons, coffeehouses and in printed books, journals, and pamphlets. The ideas of the Enlightenment undermined the authority of the monarchy and the Catholic Church and paved the way for the political revolutions of the 18th and 19th centuries. A variety of 19th-century movements, including liberalism, communism, and neoclassicism, trace their intellectual heritage to the Enlightenment.[4]

The central doctrines of the Enlightenment were individual liberty and religious tolerance, in opposition to an absolute monarchy and the fixed dogmas of the Church. The principles of sociability and utility also played an important role in circulating knowledge useful to the improvement of society at large. The Enlightenment was marked by an increasing awareness of the relationship between the mind and the everyday media of the world,[5] and by an emphasis on the scientific method and reductionism, along with increased questioning of religious orthodoxyan attitude captured by Immanuel Kant's essay Answering the Question: What is Enlightenment, where the phrase Sapere aude (Dare to know) can be found.[6]

The Age of Enlightenment was preceded by and closely associated with the Scientific Revolution.[9] Earlier philosophers whose work influenced the Enlightenment included Francis Bacon and Ren Descartes.[10] Some of the major figures of the Enlightenment included Cesare Beccaria, Denis Diderot, David Hume, Immanuel Kant, Gottfried Wilhelm Leibniz, John Locke, Montesquieu, Jean-Jacques Rousseau, Adam Smith, Hugo Grotius, Baruch Spinoza, and Voltaire.[11]

One particularly influential Enlightenment publication was the Encyclopdie (Encyclopedia). Published between 1751 and 1772 in thirty-five volumes, it was compiled by Denis Diderot, Jean le Rond d'Alembert, and a team of 150 other intellectuals. The Encyclopdie helped in spreading the ideas of the Enlightenment across Europe and beyond.[12]

Other landmark publications of the Enlightenment included Voltaire's Letters on the English (1733) and Dictionnaire philosophique (Philosophical Dictionary; 1764); Hume's A Treatise of Human Nature (1740); Montesquieu's The Spirit of the Laws (1748); Rousseau's Discourse on Inequality (1754) and The Social Contract (1762); Adam Smith's The Theory of Moral Sentiments (1759) and The Wealth of Nations (1776); and Kant's Critique of Pure Reason (1781).

Enlightenment thought was deeply influential in the political realm. European rulers such as Catherine II of Russia, Joseph II of Austria, and Frederick II of Prussia tried to apply Enlightenment thought on religious and political tolerance, which became known as enlightened absolutism.[11] Many of the major political and intellectual figures behind the American Revolution associated themselves closely with the Enlightenment: Benjamin Franklin visited Europe repeatedly and contributed actively to the scientific and political debates there and brought the newest ideas back to Philadelphia; Thomas Jefferson closely followed European ideas and later incorporated some of the ideals of the Enlightenment into the Declaration of Independence; and James Madison incorporated these ideals into the United States Constitution during its framing in 1787.[13] The ideas of the Enlightenment also played a major role in inspiring the French Revolution, which began in 1789.

Francis Bacon's empiricism and Ren Descartes' rationalist philosophy laid the foundation for enlightenment thinking.[14] Descartes attempt to construct the sciences on a secure metaphysical foundation was not as successful as his method of doubt applied in philosophic areas leading to a dualistic doctrine of mind and matter. His skepticism was refined by John Locke's Essay Concerning Human Understanding (1690) and David Hume's writings in the 1740s. His dualism was challenged by Spinoza's uncompromising assertion of the unity of matter in his Tractatus (1670) and Ethics (1677).

According to Jonathan Israel, these laid down two distinct lines of Enlightenment thought: first, the moderate variety, following Descartes, Locke, and Christian Wolff, which sought accommodation between reform and the traditional systems of power and faith, and, second, the Radical Enlightenment, inspired by the philosophy of Spinoza, advocating democracy, individual liberty, freedom of expression, and eradication of religious authority. The moderate variety tended to be deistic, whereas the radical tendency separated the basis of morality entirely from theology. Both lines of thought were eventually opposed by a conservative Counter-Enlightenment, which sought a return to faith.

In the mid-18th century, Paris became the center of philosophic and scientific activity challenging traditional doctrines and dogmas. The philosophical movement was led by Voltaire and Jean-Jacques Rousseau, who argued for a society based upon reason as in ancient Greece[18] rather than faith and Catholic doctrine, for a new civil order based on natural law, and for science based on experiments and observation. The political philosopher Montesquieu introduced the idea of a separation of powers in a government, a concept which was enthusiastically adopted by the authors of the United States Constitution. While the philosophes of the French Enlightenment were not revolutionaries and many were members of the nobility, their ideas played an important part in undermining the legitimacy of the Old Regime and shaping the French Revolution.

Francis Hutcheson, a moral philosopher and founding figure of the Scottish Enlightenment, described the utilitarian and consequentialist principle that virtue is that which provides, in his words, "the greatest happiness for the greatest numbers". Much of what is incorporated in the scientific method (the nature of knowledge, evidence, experience, and causation) and some modern attitudes towards the relationship between science and religion were developed by Hutcheson's protgs in Edinburgh, Scotland, David Hume and Adam Smith.[20][21] Hume became a major figure in the skeptical philosophical and empiricist traditions of philosophy.

Immanuel Kant (17241804) tried to reconcile rationalism and religious belief, individual freedom and political authority, as well as map out a view of the public sphere through private and public reason.[22] Kant's work continued to shape German thought and indeed all of European philosophy, well into the 20th century.[23]

Mary Wollstonecraft was one of England's earliest feminist philosophers.[24] She argued for a society based on reason and that women as well as men should be treated as rational beings. She is best known for her work A Vindication of the Rights of Woman (1791).[25]

Science played an important role in Enlightenment discourse and thought. Many Enlightenment writers and thinkers had backgrounds in the sciences and associated scientific advancement with the overthrow of religion and traditional authority in favour of the development of free speech and thought. Scientific progress during the Enlightenment included the discovery of carbon dioxide (fixed air) by the chemist Joseph Black, the argument for deep time by the geologist James Hutton, and the invention of the condensing steam engine by James Watt.[26] The experiments of Antoine Lavoisier were used to create the first modern chemical plants in Paris and the experiments of the Montgolfier brothers enabled them to launch the first manned flight in a hot-air balloon on 21 November 1783 from the Chteau de la Muette, near the Bois de Boulogne.[27]

The wide-ranging contributions to mathematics of Leonhard Euler (17071783) included major results in analysis, number theory, topology, combinatorics, graph theory, algebra, and geometry (among other fields). In applied mathematics, he made fundamental contributions to mechanics, hydraulics, acoustics, optics, and astronomy. He was based in the Imperial Academy of Sciences in St. Petersburg (17271741), then in Berlin at the Royal Prussian Academy of Sciences and Belles Lettres (17411766), and finally back in St. Petersburg at the Imperial Academy (17661783).[28]

Broadly speaking, Enlightenment science greatly valued empiricism and rational thought and was embedded with the Enlightenment ideal of advancement and progress. The study of science, under the heading of natural philosophy, was divided into physics and a conglomerate grouping of chemistry and natural history, which included anatomy, biology, geology, mineralogy, and zoology.[29] As with most Enlightenment views, the benefits of science were not seen universally: Rousseau criticized the sciences for distancing man from nature and not operating to make people happier.[30]

Science during the Enlightenment was dominated by scientific societies and academies, which had largely replaced universities as centres of scientific research and development. Societies and academies were also the backbone of the maturation of the scientific profession. Scientific academies and societies grew out of the Scientific Revolution as the creators of scientific knowledge, in contrast to the scholasticism of the university.[31] During the Enlightenment, some societies created or retained links to universities, but contemporary sources distinguished universities from scientific societies by claiming that the university's utility was in the transmission of knowledge while societies functioned to create knowledge.[32] As the role of universities in institutionalized science began to diminish, learned societies became the cornerstone of organized science. Official scientific societies were chartered by the state to provide technical expertise.[33]

Most societies were granted permission to oversee their own publications, control the election of new members and the administration of the society.[34] After 1700, a tremendous number of official academies and societies were founded in Europe and by 1789 there were over seventy official scientific societies. In reference to this growth, Bernard de Fontenelle coined the term "the Age of Academies" to describe the 18th century.[35]

Another important development was the popularization of science among an increasingly literate population. Philosophes introduced the public to many scientific theories, most notably through the Encyclopdie and the popularization of Newtonianism by Voltaire and milie du Chtelet. Some historians have marked the 18th century as a drab period in the history of science.[36]

The century saw significant advancements in the practice of medicine, mathematics, and physics; the development of biological taxonomy; a new understanding of magnetism and electricity; and the maturation of chemistry as a discipline, which established the foundations of modern chemistry.

The influence of science also began appearing more commonly in poetry and literature during the Enlightenment. Some poetry became infused with scientific metaphor and imagery, while other poems were written directly about scientific topics. Sir Richard Blackmore committed the Newtonian system to verse in Creation, a Philosophical Poem in Seven Books (1712). After Newton's death in 1727, poems were composed in his honour for decades.[37] James Thomson (17001748) penned his "Poem to the Memory of Newton", which mourned the loss of Newton, but also praised his science and legacy.[38]

Hume and other Scottish Enlightenment thinkers developed a "science of man",[39] which was expressed historically in works by authors including James Burnett, Adam Ferguson, John Millar, and William Robertson, all of whom merged a scientific study of how humans behaved in ancient and primitive cultures with a strong awareness of the determining forces of modernity. Modern sociology largely originated from this movement[40] and Hume's philosophical concepts that directly influenced James Madison (and thus the U.S. Constitution) and as popularised by Dugald Stewart, would be the basis of classical liberalism.[41]

In 1776, Adam Smith published The Wealth of Nations, often considered the first work on modern economics as it had an immediate impact on British economic policy that continues into the 21st century.[42] It was immediately preceded and influenced by Anne-Robert-Jacques Turgot, Baron de Laune drafts of Reflections on the Formation and Distribution of Wealth (Paris, 1766). Smith acknowledged indebtedness and possibly was the original English translator.[43]

Cesare Beccaria, a jurist, criminologist, philosopher, and politician and one of the great Enlightenment writers, became famous for his masterpiece Of Crimes and Punishments (1764), later translated into 22 languages,[44] which condemned torture and the death penalty and was a founding work in the field of penology and the classical school of criminology by promoting criminal justice. Another prominent intellectual was Francesco Mario Pagano, who wrote important studies such as Saggi politici (Political Essays, 1783), one of the major works of the Enlightenment in Naples; and Considerazioni sul processo criminale (Considerations on the Criminal Trial, 1787), which established him as an international authority on criminal law.[45]

The Enlightenment has long been hailed as the foundation of modern Western political and intellectual culture.[46] The Enlightenment brought political modernization to the West, in terms of introducing democratic values and institutions and the creation of modern, liberal democracies. This thesis has been widely accepted by Anglophone scholars and has been reinforced by the large-scale studies by Robert Darnton, Roy Porter, and, most recently, by Jonathan Israel.[47][48]

John Locke, one of the most influential Enlightenment thinkers,[49] based his governance philosophy in social contract theory, a subject that permeated Enlightenment political thought. The English philosopher Thomas Hobbes ushered in this new debate with his work Leviathan in 1651. Hobbes also developed some of the fundamentals of European liberal thought: the right of the individual, the natural equality of all men, the artificial character of the political order (which led to the later distinction between civil society and the state), the view that all legitimate political power must be "representative" and based on the consent of the people, and a liberal interpretation of law which leaves people free to do whatever the law does not explicitly forbid.[50]

Both Locke and Rousseau developed social contract theories in Two Treatises of Government and Discourse on Inequality, respectively. While quite different works, Locke, Hobbes, and Rousseau agreed that a social contract, in which the government's authority lies in the consent of the governed,[51] is necessary for man to live in civil society. Locke defines the state of nature as a condition in which humans are rational and follow natural law, in which all men are born equal and with the right to life, liberty, and property. However, when one citizen breaks the Law of Nature both the transgressor and the victim enter into a state of war, from which it is virtually impossible to break free. Therefore, Locke said that individuals enter into civil society to protect their natural rights via an "unbiased judge" or common authority, such as courts, to appeal to. In contrast, Rousseau's conception relies on the supposition that "civil man" is corrupted, while "natural man" has no want he cannot fulfill himself. Natural man is only taken out of the state of nature when the inequality associated with private property is established.[52] Rousseau said that people join into civil society via the social contract to achieve unity while preserving individual freedom. This is embodied in the sovereignty of the general will, the moral and collective legislative body constituted by citizens.

Locke is known for his statement that individuals have a right to "Life, Liberty, and Property" and his belief that the natural right to property is derived from labor. Tutored by Locke, Anthony Ashley-Cooper, 3rd Earl of Shaftesbury wrote in 1706: "There is a mighty Light which spreads its self over the world especially in those two free Nations of England and Holland; on whom the Affairs of Europe now turn."[53] Locke's theory of natural rights has influenced many political documents, including the United States Declaration of Independence and the French National Constituent Assembly's Declaration of the Rights of Man and of the Citizen.

The philosophes argued that the establishment of a contractual basis of rights would lead to the market mechanism and capitalism, the scientific method, religious tolerance, and the organization of states into self-governing republics through democratic means. In this view, the tendency of the philosophes in particular to apply rationality to every problem is considered the essential change.[54]

Although much of Enlightenment political thought was dominated by social contract theorists, both David Hume and Adam Ferguson criticized this camp. Hume's essay Of the Original Contract argues that governments derived from consent are rarely seen and civil government is grounded in a ruler's habitual authority and force. It is precisely because of the ruler's authority over-and-against the subject, that the subject tacitly consents and Hume says that the subjects would "never imagine that their consent made him sovereign", rather the authority did so.[55] Similarly, Ferguson did not believe citizens built the state, rather polities grew out of social development. In his 1767 An Essay on the History of Civil Society, Ferguson uses the four stages of progress, a theory that was very popular in Scotland at the time, to explain how humans advance from a hunting and gathering society to a commercial and civil society without agreeing to a social contract.

Both Rousseau's and Locke's social contract theories rest on the presupposition of natural rights, which are not a result of law or custom, but are things that all men have in pre-political societies and are therefore universal and inalienable. The most famous natural right formulation comes from John Locke in his Second Treatise, when he introduces the state of nature. For Locke, the law of nature is grounded on mutual security or the idea that one cannot infringe on another's natural rights, as every man is equal and has the same inalienable rights. These natural rights include perfect equality and freedom, as well as the right to preserve life and property. Locke also argued against slavery on the basis that enslaving oneself goes against the law of nature because one cannot surrender one's own rights: one's freedom is absolute and no-one can take it away. Additionally, Locke argues that one person cannot enslave another because it is morally reprehensible, although he introduces a caveat by saying that enslavement of a lawful captive in time of war would not go against one's natural rights.

As a spill-over of the Enlightenment, nonsecular beliefs expressed first by Quakers and then by Protestant evangelicals in Britain and the United States emerged. To these groups, slavery became "repugnant to our religion" and a "crime in the sight of God".[56] These ideas added to those expressed by Enlightenment thinkers, leading many in Britain to believe that slavery was "not only morally wrong and economically inefficient, but also politically unwise." This ideals eventually led to the abolition of slavery in Britain and the United States.[57]

The leaders of the Enlightenment were not especially democratic, as they more often look to absolute monarchs as the key to imposing reforms designed by the intellectuals. Voltaire despised democracy and said the absolute monarch must be enlightened and must act as dictated by reason and justice in other words, be a "philosopher-king".[58]

In several nations, rulers welcomed leaders of the Enlightenment at court and asked them to help design laws and programs to reform the system, typically to build stronger states. These rulers are called "enlightened despots" by historians.[59] They included Frederick the Great of Prussia, Catherine the Great of Russia, Leopold II of Tuscany and Joseph II of Austria. Joseph was over-enthusiastic, announcing many reforms that had little support so that revolts broke out and his regime became a comedy of errors and nearly all his programs were reversed.[60] Senior ministers Pombal in Portugal and Johann Friedrich Struensee in Denmark also governed according to Enlightenment ideals. In Poland, the model constitution of 1791 expressed Enlightenment ideals, but was in effect for only one year before the nation was partitioned among its neighbors. More enduring were the cultural achievements, which created a nationalist spirit in Poland.[61]

Frederick the Great, the king of Prussia from 1740 to 1786, saw himself as a leader of the Enlightenment and patronized philosophers and scientists at his court in Berlin. Voltaire, who had been imprisoned and maltreated by the French government, was eager to accept Frederick's invitation to live at his palace. Frederick explained: "My principal occupation is to combat ignorance and prejudice... to enlighten minds, cultivate morality, and to make people as happy as it suits human nature, and as the means at my disposal permit."[62]

The Enlightenment has been frequently linked to the American Revolution of 1776[63] and the French Revolution of 1789both had some intellectual influence from Thomas Jefferson in real time.[64][65] One view of the political changes that occurred during the Enlightenment is that the "consent of the governed" philosophy as delineated by Locke in Two Treatises of Government (1689) represented a paradigm shift from the old governance paradigm under feudalism known as the "divine right of kings". In this view, the revolutions of the late 1700s and early 1800s were caused by the fact that this governance paradigm shift often could not be resolved peacefully and therefore violent revolution was the result. A governance philosophy where the king was never wrong would be in direct conflict with one whereby citizens by natural law had to consent to the acts and rulings of their government.

Alexis de Tocqueville proposed the French Revolution as the inevitable result of the radical opposition created in the 18th century between the monarchy and the men of letters of the Enlightenment. These men of letters constituted a sort of "substitute aristocracy that was both all-powerful and without real power." This illusory power came from the rise of "public opinion", born when absolutist centralization removed the nobility and the bourgeoisie from the political sphere. The "literary politics" that resulted promoted a discourse of equality and was hence in fundamental opposition to the monarchical regime.[66] De Tocqueville "clearly designates... the cultural effects of transformation in the forms of the exercise of power."[67]

Enlightenment era religious commentary was a response to the preceding century of religious conflict in Europe, especially the Thirty Years' War.[69] Theologians of the Enlightenment wanted to reform their faith to its generally non-confrontational roots and to limit the capacity for religious controversy to spill over into politics and warfare while still maintaining a true faith in God. For moderate Christians, this meant a return to simple Scripture. John Locke abandoned the corpus of theological commentary in favor of an "unprejudiced examination" of the Word of God alone. He determined the essence of Christianity to be a belief in Christ the redeemer and recommended avoiding more detailed debate.[70] Anthony Collins, one of the English freethinkers, published his "Essay concerning the Use of Reason in Propositions the Evidence whereof depends on Human Testimony" (1707), in which he rejected the distinction between "above reason" and "contrary to reason", and demanded that revelation should conform to man's natural ideas of God. In the Jefferson Bible, Thomas Jefferson went further and dropped any passages dealing with miracles, visitations of angels, and the resurrection of Jesus after his death, as he tried to extract the practical Christian moral code of the New Testament.[71]

Enlightenment scholars sought to curtail the political power of organized religion and thereby prevent another age of intolerant religious war.[72] Spinoza determined to remove politics from contemporary and historical theology (e.g., disregarding Judaic law).[73] Moses Mendelssohn advised affording no political weight to any organized religion, but instead recommended that each person follow what they found most convincing.[74] They believed a good religion based in instinctive morals and a belief in God should not theoretically need force to maintain order in its believers, and both Mendelssohn and Spinoza judged religion on its moral fruits, not the logic of its theology.[75]

A number of novel ideas about religion developed with the Enlightenment, including deism and talk of atheism. According to Thomas Paine, deism is the simple belief in God the Creator, with no reference to the Bible or any other miraculous source. Instead, the deist relies solely on personal reason to guide his creed,[76] which was eminently agreeable to many thinkers of the time.[77] Atheism was much discussed, but there were few proponents. Wilson and Reill note: "In fact, very few enlightened intellectuals, even when they were vocal critics of Christianity, were true atheists. Rather, they were critics of orthodox belief, wedded rather to skepticism, deism, vitalism, or perhaps pantheism."[78] Some followed Pierre Bayle and argued that atheists could indeed be moral men.[79] Many others like Voltaire held that without belief in a God who punishes evil, the moral order of society was undermined. That is, since atheists gave themselves to no Supreme Authority and no law and had no fear of eternal consequences, they were far more likely to disrupt society.[80] Bayle (16471706) observed that, in his day, "prudent persons will always maintain an appearance of [religion]," and he believed that even atheists could hold concepts of honor and go beyond their own self-interest to create and interact in society.[81] Locke said that if there were no God and no divine law, the result would be moral anarchy: every individual "could have no law but his own will, no end but himself. He would be a god to himself, and the satisfaction of his own will the sole measure and end of all his actions."[82]

The "Radical Enlightenment" promoted the concept of separating church and state, an idea that is often credited to English philosopher John Locke (16321704).[86] According to his principle of the social contract, Locke said that the government lacked authority in the realm of individual conscience, as this was something rational people could not cede to the government for it or others to control. For Locke, this created a natural right in the liberty of conscience, which he said must therefore remain protected from any government authority.

These views on religious tolerance and the importance of individual conscience, along with the social contract, became particularly influential in the American colonies and the drafting of the United States Constitution.[87] Thomas Jefferson called for a "wall of separation between church and state" at the federal level. He previously had supported successful efforts to disestablish the Church of England in Virginia[88] and authored the Virginia Statute for Religious Freedom.[89] Jefferson's political ideals were greatly influenced by the writings of John Locke, Francis Bacon, and Isaac Newton,[90] whom he considered the three greatest men that ever lived.[91]

The Enlightenment took hold in most European countries and influenced nations globally, often with a specific local emphasis. For example, in France it became associated with anti-government and anti-Church radicalism, while in Germany it reached deep into the middle classes, where it expressed a spiritualistic and nationalistic tone without threatening governments or established churches.[92] Government responses varied widely. In France, the government was hostile, and the philosophes fought against its censorship, sometimes being imprisoned or hounded into exile. The British government, for the most part, ignored the Enlightenment's leaders in England and Scotland, although it did give Isaac Newton a knighthood and a very lucrative government office. A common theme among most countries which derived Enlightenment ideas from Europe was the intentional non-inclusion of Enlightenment philosophies pertaining to slavery. Originally during the French Revolution, a revolution deeply inspired by Enlightenment philosophy, "France's revolutionary government had denounced slavery, but the property-holding 'revolutionaries' then remembered their bank accounts."[93] Slavery frequently showed the limitations of the Enlightenment ideology as it pertained to European colonialism, since many colonies of Europe operated on a plantation economy fueled by slave labor. In 1791, the Haitian Revolution, a slave rebellion by emancipated slaves against French colonial rule in the colony of Saint-Domingue, broke out. European nations and the United States, despite the strong support for Enlightenment ideals, refused to "[give support] to Saint-Domingue's anti-colonial struggle."[93]

The very existence of an English Enlightenment has been hotly debated by scholars. The majority of textbooks on British history make little or no mention of an English Enlightenment. Some surveys of the entire Enlightenment include England and others ignore it, although they do include coverage of such major intellectuals as Joseph Addison, Edward Gibbon, John Locke, Isaac Newton, Alexander Pope, Joshua Reynolds, and Jonathan Swift.[94] Freethinking, a term describing those who stood in opposition to the institution of the Church, and the literal belief in the Bible, can be said to have begun in England no later than 1713, when Anthony Collins wrote his "Discourse of Free-thinking", which gained substantial popularity. This essay attacked the clergy of all churches and was a plea for deism. Roy Porter argues that the reasons for this neglect were the assumptions that the movement was primarily French-inspired, that it was largely a-religious or anti-clerical, and that it stood in outspoken defiance to the established order.[95] Porter admits that, after the 1720s, England could claim thinkers to equal Diderot, Voltaire, or Rousseau. However, its leading intellectuals such as Edward Gibbon,[96] Edmund Burke and Samuel Johnson were all quite conservative and supportive of the standing order. Porter says the reason was that Enlightenment had come early to England and had succeeded so that the culture had accepted political liberalism, philosophical empiricism, and religious toleration of the sort that intellectuals on the continent had to fight for against powerful odds. Furthermore, England rejected the collectivism of the continent and emphasized the improvement of individuals as the main goal of enlightenment.[97]

In the Scottish Enlightenment, the principles of sociability, equality, and utility were disseminated in schools and universities, many of which used sophisticated teaching methods which blended philosophy with daily life.[98] Scotland's major cities created an intellectual infrastructure of mutually supporting institutions such as schools, universities, reading societies, libraries, periodicals, museums, and masonic lodges.[99] The Scottish network was "predominantly liberal Calvinist, Newtonian, and 'design' oriented in character which played a major role in the further development of the transatlantic Enlightenment".[100] In France, Voltaire said that "we look to Scotland for all our ideas of civilization".[101] The focus of the Scottish Enlightenment ranged from intellectual and economic matters to the specifically scientific as in the work of William Cullen, physician and chemist; James Anderson, an agronomist; Joseph Black, physicist and chemist; and James Hutton, the first modern geologist.[20][102]

Several Americans, especially Benjamin Franklin and Thomas Jefferson, played a major role in bringing Enlightenment ideas to the New World and in influencing British and French thinkers.[103] Franklin was influential for his political activism and for his advances in physics.[104][105] The cultural exchange during the Age of Enlightenment ran in both directions across the Atlantic. Thinkers such as Paine, Locke, and Rousseau all take Native American cultural practices as examples of natural freedom.[106] The Americans closely followed English and Scottish political ideas, as well as some French thinkers such as Montesquieu.[107] As deists, they were influenced by ideas of John Toland (16701722) and Matthew Tindal (16561733). During the Enlightenment there was a great emphasis upon liberty, republicanism, and religious tolerance. There was no respect for monarchy or inherited political power. Deists reconciled science and religion by rejecting prophecies, miracles, and biblical theology. Leading deists included Thomas Paine in The Age of Reason and by Thomas Jefferson in his short Jefferson Bible from which he removed all supernatural aspects.[108]

Prussia took the lead among the German states in sponsoring the political reforms that Enlightenment thinkers urged absolute rulers to adopt. There were important movements as well in the smaller states of Bavaria, Saxony, Hanover, and the Palatinate. In each case, Enlightenment values became accepted and led to significant political and administrative reforms that laid the groundwork for the creation of modern states.[109] The princes of Saxony, for example, carried out an impressive series of fundamental fiscal, administrative, judicial, educational, cultural, and general economic reforms. The reforms were aided by the country's strong urban structure and influential commercial groups and modernized pre-1789 Saxony along the lines of classic Enlightenment principles.[110][111]

Before 1750, the German upper classes looked to France for intellectual, cultural, and architectural leadership, as French was the language of high society. By the mid-18th century, the Aufklrung (The Enlightenment) had transformed German high culture in music, philosophy, science, and literature. Christian Wolff (16791754) was the pioneer as a writer who expounded the Enlightenment to German readers and legitimized German as a philosophic language.[112]

Johann Gottfried von Herder (17441803) broke new ground in philosophy and poetry, as a leader of the Sturm und Drang movement of proto-Romanticism. Weimar Classicism (Weimarer Klassik) was a cultural and literary movement based in Weimar that sought to establish a new humanism by synthesizing Romantic, classical, and Enlightenment ideas. The movement (from 1772 until 1805) involved Herder as well as polymath Johann Wolfgang von Goethe (17491832) and Friedrich Schiller (17591805), a poet and historian. Herder argued that every group of people had its own particular identity, which was expressed in its language and culture. This legitimized the promotion of German language and culture and helped shape the development of German nationalism. Schiller's plays expressed the restless spirit of his generation, depicting the hero's struggle against social pressures and the force of destiny.[113]

German music, sponsored by the upper classes, came of age under composers Johann Sebastian Bach (16851750), Joseph Haydn (17321809), and Wolfgang Amadeus Mozart (17561791).[114]

In remote Knigsberg, philosopher Immanuel Kant (17241804) tried to reconcile rationalism and religious belief, individual freedom, and political authority. Kant's work contained basic tensions that would continue to shape German thought and indeed all of European philosophy well into the 20th century.[115]

The German Enlightenment won the support of princes, aristocrats, and the middle classes and it permanently reshaped the culture.[116] However, there was a conservatism among the elites that warned against going too far.[117]

In the 1780s, Lutheran ministers Johann Heinrich Schulz and Karl Wilhelm Brumbey got in trouble with their preaching as they were attacked and ridiculed by Immanuel Kant, Wilhelm Abraham Teller and others. In 1788, Prussia issued an "Edict on Religion" that forbade preaching any sermon that undermined popular belief in the Holy Trinity and the Bible. The goal was to avoid skepticism, deism, and theological disputes that might impinge on domestic tranquility. Men who doubted the value of Enlightenment favoured the measure, but so too did many supporters. German universities had created a closed elite that could debate controversial issues among themselves, but spreading them to the public was seen as too risky. This intellectual elite was favoured by the state, but that might be reversed if the process of the Enlightenment proved politically or socially destabilizing.[118]

In the Habsburg Empire, which controlled a large part of Europe at the time, chiefly around Austria, the rule of Maria Theresa was the first age considered influenced by the Enlightenment in some areas, while still remaining quite conservative in others. The subsequent brief reign of her son Joseph II was also marked by a conflict of these two paradigms, with Josephinism finding serious opposition. The brief and contentious rule of Leopold II, an early opponent of capital punishment, was still marked mostly by relations with France, likewise with Francis II.

In Italy the main centers of diffusion of the Enlightenment were Naples and Milan:[119] in both cities the intellectuals took public office and collaborated with the Bourbon and Habsburg administrations. In Naples, Antonio Genovesi, Ferdinando Galiani, and Gaetano Filangieri were active under the tolerant King Charles of Bourbon. However, the Neapolitan Enlightenment, like Vico's philosophy, remained almost always in the theoretical field.[120] Only later, many Enlighteners animated the unfortunate experience of the Parthenopean Republic.

In Milan, however, the movement strove to find concrete solutions to problems. The center of discussions was the magazine Il Caff (17621764), founded by brothers Pietro and Alessandro Verri (famous philosophers and writers, as well as their brother Giovanni), who also gave life to the Accademia dei Pugni, founded in 1761.

Minor centers were Tuscany, Veneto, and Piedmont, where among others, Pompeo Neri worked.

From Naples, Antonio Genovesi (17131769) influenced a generation of southern Italian intellectuals and university students. His textbook Della diceosina, o sia della Filosofia del Giusto e dell'Onesto (1766) was a controversial attempt to mediate between the history of moral philosophy on the one hand and the specific problems encountered by 18th-century commercial society on the other. It contained the greater part of Genovesi's political, philosophical, and economic thought guidebook for Neapolitan economic and social development.[121]

Science flourished as Alessandro Volta and Luigi Galvani made break-through discoveries in electricity. Pietro Verri was a leading economist in Lombardy. Historian Joseph Schumpeter states he was "the most important pre-Smithian authority on Cheapness-and-Plenty".[122] The most influential scholar on the Italian Enlightenment has been Franco Venturi.[123][124] Italy also produced some of the Enlightenment's greatest legal theorists, including Cesare Beccaria, Giambattista Vico, and Francesco Mario Pagano. Beccaria in particular is now considered one of the fathers of classical criminal theory as well as modern penology.[125] Beccaria is famous for his masterpiece On Crimes and Punishments (1764), a treatise (later translated into 22 languages) that served as one of the earliest prominent condemnations of torture and the death penalty and thus a landmark work in anti-death penalty philosophy.[44]

When Charles II the last Spanish Hapsburg monarch died in 1700, it touched out a major European conflict about succession and the fate of Spain and the Spanish Empire. The War of the Spanish Succession (17001715) brought Bourbon prince Philip, Duke of Anjou to the throne of Spain as Philip V. Under the 1715 Treaty of Utrecht, the French and the Spanish Bourbons could not unite, with Philip renouncing any rights to the French throne. The political restriction did not impede strong French influence of the Age of Enlightenment on Spain, the Spanish monarchs, the Spanish Empire.[126][127] Philip did not come into effective power until 1715 and began implementing administrative reforms to try to stop the decline of the Spanish Empire. Under Charles III, the crown began to implement serious structural changes, generally known as the Bourbon Reforms. The crown curtailed the power of the Catholic Church and the clergy, established a standing military in Spanish America, established new viceroyalties and reorganized administrative districts into intendancies. Freer trade was promoted under comercio libre in which regions could trade with companies sailing from any other Spanish port, rather than the restrictive mercantile system limiting trade. The crown sent out scientific expeditions to assert Spanish sovereignty over territories it claimed but did not control, but also importantly to discover the economic potential of its far-flung empire. Botanical expeditions sought plants that could be of use to the empire.[128] One of the best acts by Charles IV, a monarch not notable for his good judgment, was to give Prussian scientist, Baron Alexander von Humboldt, free rein to travel and gather information about the Spanish Empire during his five-year, self-funded expedition. Crown officials were to aid Humboldt in any way they could, so that he was able to get access to expert information. Given that Spain's empire was closed to foreigners, Humboldt's unfettered access is quite remarkable. His observations of New Spain, published as the Political Essay on the Kingdom of New Spain remains an important scientific and historical text.[129] When Napoleon invaded Spain in 1808, Ferdinand VII abdicated and Napoleon placed his brother Joseph Bonaparte on the throne. To add legitimacy to this move, the Bayonne Constitution was promulgated, which included representation from Spain's overseas components, but most Spaniards rejected the whole Napoleonic project. A war of national resistance erupted. The Cortes de Cdiz (parliament) was convened to rule Spain in the absence of the legitimate monarch, Ferdinand. It created a new governing document, the Constitution of 1812, which laid out three branches of government: executive, legislative, and judicial, put limits on the king by creating a constitutional monarchy, defined citizens as those in the Spanish Empire without African ancestry, established universal manhood suffrage, and established public education starting with primary school through university as well as freedom of expression. The constitution was in effect from 1812 until 1814, when Napoleon was defeated and Ferdinand was restored to the throne of Spain. Upon his return, Ferdinand repudiated the constitution and reestablished absolutist rule.[130] The French invasion of Spain sparked a crisis of legitimacy of rule in Spanish America, with many regions establishing juntas to rule in the name of Ferdinand VII. Most of Spanish America fought for independence, leaving only Cuba and Puerto Rico, as well as the Philippines as overseas components of the Spanish Empire. All of newly independent and sovereign nations became republics by 1824, with written constitutions. Mexico's brief post-independence monarchy was overthrown and replaced by a federal republic under the Constitution of 1824, inspired by both the U.S. and Spanish constitutions.

The Haitian Revolution began in 1791 and ended in 1804 and shows how Enlightenment ideas "were part of complex transcultural flows."[3] Radical ideas in Paris during and after the French Revolution were mobilized in Haiti, such as by Toussaint L'Ouverture.[3] Toussaint had read the critique of European colonialism in Guillaume Thomas Raynal's book Histoire des deux Indes and "was particularly impressed by Raynal's prediction of the coming of a 'Black Spartacus.'"[3]

The revolution combined Enlightenment ideas with the experiences of the slaves in Haiti, two-thirds of whom had been born in Africa and could "draw on specific notions of kingdom and just government from Western and Central Africa, and to employ religious practices such as voodoo for the formation of revolutionary communities."[3] The revolution also affected France and "forced the French National Convention to abolish slavery in 1794."[3]

The Enlightenment in Portugal (Iluminismo) was heavily marked by the rule of the Prime Minister Marquis of Pombal under King Joseph I of Portugal from 1756 to 1777. Following the 1755 Lisbon earthquake which destroyed a large part of Lisbon, the Marquis of Pombal implemented important economic policies to regulate commercial activity (in particular with Brazil and England), and to standardise quality throughout the country (for example by introducing the first integrated industries in Portugal). His reconstruction of Lisbon's riverside district in straight and perpendicular streets (the Lisbon Baixa), methodically organized to facilitate commerce and exchange (for example by assigning to each street a different product or service), can be seen as a direct application of the Enlightenment ideas to governance and urbanism. His urbanistic ideas, also being the first large-scale example of earthquake engineering, became collectively known as Pombaline style, and were implemented throughout the kingdom during his stay in office. His governance was as enlightened as ruthless, see for example the Tvora affair.

In literature, the first Enlightenment ideas in Portugal can be traced back to the diplomat, philosopher, and writer Antnio Vieira (16081697),[131] who spent a considerable amount of his life in colonial Brazil denouncing discriminations against New Christians and the Indigenous peoples in Brazil. His works remain today as one of the best pieces of Portuguese literature[citation needed]. During the 18th century, enlightened literary movements such as the Arcdia Lusitana (lasting from 1756 until 1776, then replaced by the Nova Arcdia in 1790 until 1794) surfaced in the academic medium, in particular involving former students of the University of Coimbra. A distinct member of this group was the poet Manuel Maria Barbosa du Bocage.The physician Antnio Nunes Ribeiro Sanches was also an important Enlightenment figure, contributing to the Encyclopdie and being part of the Russian court.

The ideas of the Enlightenment also influenced various economists and anti-colonial intellectuals throughout the Portuguese Empire, such as Jos de Azeredo Coutinho, Jos da Silva Lisboa, Cludio Manoel da Costa, and Toms Antnio Gonzaga.

The Napoleonic invasion of Portugal had consequences for the Portuguese monarchy. With the aid of the British navy, the Portuguese royal family was evacuated to Brazil, its most important colony. Even though Napoleon had been defeated, the royal court remained in Brazil. The Liberal Revolution of 1820 forced the return of the royal family to Portugal. The terms by which the restored king was to rule was a constitutional monarchy under the Constitution of Portugal. Brazil declared its independence of Portugal in 1822, and became a monarchy.

In Russia, the government began to actively encourage the proliferation of arts and sciences in the mid-18th century. This era produced the first Russian university, library, theatre, public museum, and independent press. Like other enlightened despots, Catherine the Great played a key role in fostering the arts, sciences and education. She used her own interpretation of Enlightenment ideals, assisted by notable international experts such as Voltaire (by correspondence) and in residence world class scientists such as Leonhard Euler and Peter Simon Pallas. The national Enlightenment differed from its Western European counterpart in that it promoted further modernization of all aspects of Russian life and was concerned with attacking the institution of serfdom in Russia. The Russian Enlightenment centered on the individual instead of societal enlightenment and encouraged the living of an enlightened life.[132] A powerful element was prosveshchenie which combined religious piety, erudition, and commitment to the spread of learning. However, it lacked the skeptical and critical spirit of the Western European Enlightenment.[134]

Enlightenment ideas (owiecenie) emerged late in Poland, as the Polish middle class was weaker and szlachta (nobility) culture (Sarmatism) together with the PolishLithuanian Commonwealth political system (Golden Liberty) were in deep crisis. The political system was built on aristocratic republicanism, but was unable to defend itself against powerful neighbors Russia, Prussia, and Austria as they repeatedly sliced off regions until nothing was left of independent Poland. The period of Polish Enlightenment began in the 1730s1740s and especially in theatre and the arts peaked in the reign of King Stanisaw August Poniatowski (second half of the 18th century). Warsaw was a main centre after 1750, with an expansion of schools and educational institutions and the arts patronage held at the Royal Castle.[135] Leaders promoted tolerance and more education. They included King Stanislaw II Poniatowski and reformers Piotr Switkowski, Antoni Poplawski, Josef Niemcewicz, and Jsef Pawlinkowski, as well as Baudouin de Cortenay, a Polonized dramatist. Opponents included Florian Jaroszewicz, Gracjan Piotrowski, Karol Wyrwicz, and Wojciech Skarszewski.[136]

The movement went into decline with the Third Partition of Poland (1795) a national tragedy inspiring a short period of sentimental writing and ended in 1822, replaced by Romanticism.[137]

Eighteenth-century China experienced "a trend towards seeing fewer dragons and miracles, not unlike the disenchantment that began to spread across the Europe of the Enlightenment."[3] Furthermore, "some of the developments that we associate with Europe's Enlightenment resemble events in China remarkably."[3]

During this time, ideals of Chinese society were reflected in "the reign of the Qing emperors Kangxi (16611722) and Qianlong (17361795); China was posited as the incarnation of an enlightened and meritocratic societyand instrumentalized for criticisms of absolutist rule in Europe."[3]

From 1641 to 1853, the Tokugawa shogunate of Japan enforced a policy called kaikin. The policy prohibited foreign contact with most outside countries.[138]

Robert Bellah found "origins of modern Japan in certain strands of Confucian thinking, a 'functional analogue to the Protestant Ethic' that Max Weber singled out as the driving force behind Western capitalism."[3]

Japanese Confucian and Enlightenment ideas were brought together, for example, in the work of the Japanese reformer Tsuda Mamichi in the 1870s, who said, "Whenever we open our mouths...it is to speak of 'enlightenment.'"[3]

In Japan and much of East Asia, Confucian ideas were not replaced but "ideas associated with the Enlightenment were instead fused with the existing cosmologywhich in turn was refashioned under conditions of global interaction."[3] In Japan in particular, the term ri, which is the Confucian idea of "order and harmony on human society" also came to represent "the idea of laissez-faire and the rationality of market exchange."[3]

By the 1880s, the slogan "Civilization and Enlightenment" became potent throughout Japan, China, and Korea and was employed to address challenges of globalization.[3]

During this time, Korea "aimed at isolation" and was known as the "hermit kingdom", but became awakened to Enlightenment ideas by the 1890s such as with the activities of the Independence Club.[3]

Korea was influenced by China and Japan but also found its own Enlightenment path with the Korean intellectual Yu Kilchun who popularized the term Enlightenment throughout Korea.[3] The use of Enlightenment ideas was a "response to a specific situation in Korea in the 1890s, and not a belated answer to Voltaire."[3]

In eighteenth-century India, Tipu Sultan was an enlightened monarch, who "was one of the founding members of the (French) Jacobin Club in Seringapatam, had planted a liberty tree, and asked to be addressed as 'Tipu Citoyen,'" which means Citizen Tipu.[3]

In parts of India, an important movement called the "Bengal Renaissance" led to Enlightenment reforms beginning in the 1820s.[3] Rammohan Roy was a reformer who "fused different traditions in his project of social reform that made him a proponent of a 'religion of reason.'"[3]

Eighteenth-century Egypt had "a form of 'cultural revival' in the makingspecifically Islamic origins of modernization long before Napoleon's Egyptian campaign."[3] Napoleon's expedition into Egypt further encouraged "social transformations that harked back to debates about inner-Islamic reform, but now were also legitimized by referring to the authority of the Enlightenment."[3]

A major intellectual influence on Islamic modernism and expanding the Enlightenment in Egypt, Rifa al-Tahtawi "oversaw the publication of hundreds of European works in the Arabic language."[3]

The Enlightenment began to influence the Ottoman Empire in the 1830s and continued into the late nineteenth century.[3] Namik Kemal, a political activist and member of the Young Ottomans, drew on major Enlightenment thinkers and "a variety of intellectual resources in his quest for social and political reform."[3] In 1893, Kemal responded to Ernest Renan, who had indicted the Islamic religion, with his own version of the Enlightenment, which "was not a poor copy of French debates in the eighteenth century, but an original position responding to the exigencies of Ottoman society in the late nineteenth century."[3]

The Enlightenment has always been contested territory. According to Keith Thomas, its supporters "hail it as the source of everything that is progressive about the modern world. For them, it stands for freedom of thought, rational inquiry, critical thinking, religious tolerance, political liberty, scientific achievement, the pursuit of happiness, and hope for the future."[139] Thomas adds that its detractors accuse it of shallow rationalism, nave optimism, unrealistic universalism, and moral darkness. From the start, conservative and clerical defenders of traditional religion attacked materialism and skepticism as evil forces that encouraged immorality. By 1794, they pointed to the Terror during the French Revolution as confirmation of their predictions. As the Enlightenment was ending, Romantic philosophers argued that excessive dependence on reason was a mistake perpetuated by the Enlightenment because it disregarded the bonds of history, myth, faith, and tradition that were necessary to hold society together.[140]

Ritchie Robertson portrays it as a grand intellectual and political program, offering a "science" of society modeled on the powerful physical laws of Newton. "Social science" was seen as the instrument of human improvement. It would expose truth and expand human happiness.[141]

The term "Enlightenment" emerged in English in the later part of the 19th century,[142] with particular reference to French philosophy, as the equivalent of the French term Lumires (used first by Dubos in 1733 and already well established by 1751). From Immanuel Kant's 1784 essay "Beantwortung der Frage: Was ist Aufklrung?" ("Answering the Question: What is Enlightenment?"), the German term became Aufklrung (aufklren=to illuminate; sich aufklren=to clear up). However, scholars have never agreed on a definition of the Enlightenment, or on its chronological or geographical extent. Terms like les Lumires (French), illuminismo (Italian), ilustracin (Spanish) and Aufklrung (German) referred to partly overlapping movements. Not until the late nineteenth century did English scholars agree they were talking about "the Enlightenment".[140][143]

Enlightenment historiography began in the period itself, from what Enlightenment figures said about their work. A dominant element was the intellectual angle they took. D'Alembert's Preliminary Discourse of l'Encyclopdie provides a history of the Enlightenment which comprises a chronological list of developments in the realm of knowledge of which the Encyclopdie forms the pinnacle.[144] In 1783, Jewish philosopher Moses Mendelssohn referred to Enlightenment as a process by which man was educated in the use of reason.[145] Immanuel Kant called Enlightenment "man's release from his self-incurred tutelage", tutelage being "man's inability to make use of his understanding without direction from another".[146] "For Kant, Enlightenment was mankind's final coming of age, the emancipation of the human consciousness from an immature state of ignorance".[147] The German scholar Ernst Cassirer called the Enlightenment "a part and a special phase of that whole intellectual development through which modern philosophic thought gained its characteristic self-confidence and self-consciousness".[148] According to historian Roy Porter, the liberation of the human mind from a dogmatic state of ignorance, is the epitome of what the Age of Enlightenment was trying to capture.[149]

Bertrand Russell saw the Enlightenment as a phase in a progressive development which began in antiquity and that reason and challenges to the established order were constant ideals throughout that time.[150] Russell said that the Enlightenment was ultimately born out of the Protestant reaction against the Catholic Counter-Reformation and that philosophical views such as affinity for democracy against monarchy originated among 16th-century Protestants to justify their desire to break away from the Catholic Church. Although many of these philosophical ideals were picked up by Catholics, Russell argues that by the 18th century the Enlightenment was the principal manifestation of the schism that began with Martin Luther.[150]

Jonathan Israel rejects the attempts of postmodern and Marxian historians to understand the revolutionary ideas of the period purely as by-products of social and economic transformations. He instead focuses on the history of ideas in the period from 1650 to the end of the 18th century and claims that it was the ideas themselves that caused the change that eventually led to the revolutions of the latter half of the 18th century and the early 19th century. Israel argues that until the 1650s Western civilization "was based on a largely shared core of faith, tradition, and authority".

There is little consensus on the precise beginning of the Age of Enlightenment, though several historians and philosophers argue that it was marked by Descartes' 1637 philosophy of Cogito, ergo sum ("I think, therefore I am"), which shifted the epistemological basis from external authority to internal certainty.[154][155][156] In France, many cited the publication of Isaac Newton's Principia Mathematica (1687),[157] which built upon the work of earlier scientists and formulated the laws of motion and universal gravitation.[158] The middle of the 17th century (1650) or the beginning of the 18th century (1701) are often used as epochs.[citation needed] French historians usually place the Sicle des Lumires ("Century of Enlightenments") between 1715 and 1789: from the beginning of the reign of Louis XV until the French Revolution.[159] Most scholars use the last years of the century, often choosing the French Revolution of 1789 or the beginning of the Napoleonic Wars (18041815) as a convenient point in time with which to date the end of the Enlightenment.[160]

In recent years, scholars have expanded the time span and global perspective of the Enlightenment by examining: (1) how European intellectuals did not work alone and other people helped spread and adapt Enlightenment ideas, (2) how Enlightenment ideas were "a response to cross-border interaction and global integration", and (3) how the Enlightenment "continued throughout the nineteenth century and beyond."[3] The Enlightenment "was not merely a history of diffusion" and "was the work of historical actors around the world... who invoked the term... for their own specific purposes."[3]

In the 1947 book Dialectic of Enlightenment, Frankfurt School philosophers Max Horkheimer and Theodor W. Adorno argued:

Enlightenment, understood in the widest sense as the advance of thought, has always aimed at liberating human beings from fear and installing them as masters. Yet the wholly enlightened earth radiates under the sign of disaster triumphant.[161]

Extending Horkheimer and Adorno's argument, intellectual historian Jason Josephson-Storm has argued that any idea of the Age of Enlightenment as a clearly defined period that is separate from the earlier Renaissance and later Romanticism or Counter-Enlightenment constitutes a myth. Josephson-Storm points out that there are vastly different and mutually contradictory periodizations of the Enlightenment depending on nation, field of study, and school of thought; that the term and category of "Enlightenment" referring to the Scientific Revolution was actually applied after the fact; that the Enlightenment did not see an increase in disenchantment or the dominance of the mechanistic worldview; and that a blur in the early modern ideas of the humanities and natural sciences makes it hard to circumscribe a Scientific Revolution.[162] Josephson-Storm defends his categorization of the Enlightenment as "myth" by noting the regulative role ideas of a period of Enlightenment and disenchantment play in modern Western culture, such that belief in magic, spiritualism, and even religion appears somewhat taboo in intellectual strata.[163]

In the 1970s, study of the Enlightenment expanded to include the ways Enlightenment ideas spread to European colonies and how they interacted with indigenous cultures and how the Enlightenment took place in formerly unstudied areas such as Italy, Greece, the Balkans, Poland, Hungary, and Russia.[164]

Intellectuals such as Robert Darnton and Jrgen Habermas have focused on the social conditions of the Enlightenment. Habermas described the creation of the "bourgeois public sphere" in 18th-century Europe, containing the new venues and modes of communication allowing for rational exchange. Habermas said that the public sphere was bourgeois, egalitarian, rational, and independent from the state, making it the ideal venue for intellectuals to critically examine contemporary politics and society, away from the interference of established authority. While the public sphere is generally an integral component of the social study of the Enlightenment, other historians[note 3] have questioned whether the public sphere had these characteristics.

In contrast to the intellectual historiographical approach of the Enlightenment, which examines the various currents or discourses of intellectual thought within the European context during the 17th and 18th centuries, the cultural (or social) approach examines the changes that occurred in European society and culture. This approach studies the process of changing sociabilities and cultural practices during the Enlightenment.

One of the primary elements of the culture of the Enlightenment was the rise of the public sphere, a "realm of communication marked by new arenas of debate, more open and accessible forms of urban public space and sociability, and an explosion of print culture", in the late 17th century and 18th century.[165] Elements of the public sphere included that it was egalitarian, that it discussed the domain of "common concern", and that argument was founded on reason.[166] Habermas uses the term "common concern" to describe those areas of political/social knowledge and discussion that were previously the exclusive territory of the state and religious authorities, now open to critical examination by the public sphere. The values of this bourgeois public sphere included holding reason to be supreme, considering everything to be open to criticism (the public sphere is critical), and the opposition of secrecy of all sorts.[167]

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Arizona cryonics facility preserves bodies to revive later

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SCOTTSDALE, Ariz., Oct 12 (Reuters) - Time and death are "on pause" for some people in Scottsdale, Arizona.

Inside tanks filled with liquid nitrogen are the bodies and heads of 199 humans who opted to be cryopreserved in hopes of being revived in the future when science has advanced beyond what it is capable of today. Many of the "patients," as Alcor Life Extension Foundation calls them, were terminally ill with cancer, ALS or other diseases with no present-day cure.

Matheryn Naovaratpong, a Thai girl with brain cancer, is the youngest person to be cryopreserved, at the age of 2 in 2015.

"Both her parents were doctors and she had multiple brain surgeries and nothing worked, unfortunately. So they contacted us," said Max More, chief executive of Alcor, a nonprofit which claims to be the world leader in cryonics.

Bitcoin pioneer Hal Finney, another Alcor patient, had his body cryopreserved after death from ALS in 2014.

The cryopreservation process begins after a person is declared legally dead. Blood and other fluids are removed from the patient's body and replaced with chemicals designed to prevent the formation of damaging ice crystals. Vitrified at extremely cold temperatures, Alcor patients are then placed in tanks at the Arizona facility "for as long as it takes for technology to catch up," More said.

The minimum cost is $200,000 for a body and $80,000 for the brain alone. Most of Alcor's almost 1,400 living "members" pay by making the company the beneficiary of life insurance policies equal to the cost, More said.

More's wife Natasha Vita-More likens the process to taking a trip to the future.

"The disease or injury cured or fixed, and the person has a new body cloned or a whole body prosthetic or their body reanimated and (can) meet up with their friends again," she said.

Many medical professionals disagree, said Arthur Caplan, who heads the medical ethics division at New York University's Grossman School of Medicine.

"This notion of freezing ourselves into the future is pretty science fiction and it's naive," he said. "The only group... getting excited about the possibility are people who specialize in studying the distant future or people who have a stake in wanting you to pay the money to do it."

Reporting by Liliana Salgado; Editing by Richard Chang

Our Standards: The Thomson Reuters Trust Principles.

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Artificial Intelligence (AI) Services & Solutions | Accenture

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Although 90% of todays businesses have adopted cloud, only one third are achieving the anticipated ROI. The most advanced companies understand that while cloud sets you up with next-level computing power and access to new kinds of data in the right quantity and quality, AI is the bridge to convert that data into business value. Its no surprise the entire C-suite is now involved in the AI agenda and theyre asking whats next.

Thats where Applied Intelligence comes in. We believe that cloud is the enabler, data is the driver, and AI is the differentiator. We bring them together to help you make smarter, faster decisions that help change your organization and enable growthat scale. And because we understand that people are central to the success of any technology transformation, our global team of experts bring the cross-functional skills to both deliver business outcomes and facilitate cultural change empowering your workforce to use data and AI responsibly.

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