The Prometheus League
Breaking News and Updates
- Abolition Of Work
- Alternative Medicine
- Artificial Intelligence
- Atlas Shrugged
- Ayn Rand
- Basic Income Guarantee
- Big Tech
- Black Lives Matter
- Boca Chica Texas
- Casino Affiliate
- Cbd Oil
- Chess Engines
- Cloud Computing
- Conscious Evolution
- Corona Virus
- Cosmic Heaven
- Designer Babies
- Donald Trump
- Elon Musk
- Ethical Egoism
- Eugenic Concepts
- Fake News
- Fifth Amendment
- Fifth Amendment
- Financial Independence
- First Amendment
- Fiscal Freedom
- Food Supplements
- Fourth Amendment
- Fourth Amendment
- Free Speech
- Freedom of Speech
- Gene Medicine
- Genetic Engineering
- Germ Warfare
- Golden Rule
- Government Oppression
- High Seas
- Hubble Telescope
- Human Genetic Engineering
- Human Genetics
- Human Longevity
- Immortality Medicine
- Intentional Communities
- Jacinda Ardern
- Jordan Peterson
- Las Vegas
- Life Extension
- Marie Byrd Land
- Mars Colonization
- Mars Colony
- Mind Uploading
- Minerva Reefs
- Modern Satanism
- Moon Colonization
- National Vanguard
- New Utopia
- New Zealand
- Online Casino
- Online Gambling
- Personal Empowerment
- Political Correctness
- Politically Incorrect
- Post Human
- Post Humanism
- Private Islands
- Proud Boys
- Quantum Computing
- Quantum Physics
- Resource Based Economy
- Ron Paul
- Second Amendment
- Second Amendment
- Socio-economic Collapse
- Space Exploration
- Space Station
- Space Travel
- Sports Betting
- Teilhard De Charden
- Terraforming Mars
- The Singularity
- Tor Browser
- Transhuman News
- Victimless Crimes
- Virtual Reality
- Wage Slavery
- War On Drugs
- Zeitgeist Movement
The Evolutionary Perspective
Daily Archives: June 3, 2022
Posted: June 3, 2022 at 1:08 pm
Doctor Robert Willan was the first to accurately describe the different types of psoriasis in the early 1800s. In the early 1960s, experts found that psoriasis was an autoimmune disorder, and modern treatment began in the mid-1900s.
In 1809, the English doctor Robert Willan was the first to develop an accurate description of the different types of psoriasis. While doctors learned more about the condition over the years, a pivotal finding emerged in 1963, when E. J. Van Scott found that psoriasis was an autoimmune disorder.
Modern treatment for this condition became available in the mid-1900s, and doctors still use these treatments today. Options include ultraviolet light and medications to reduce inflammation and suppress the immune system.
This article discusses the history and discovery of psoriasis and how treatment has changed.
According to the Psoriasis and Psoriatic Arthritis Alliance, people were aware of psoriasis as early as ancient Greece. Hippocrates wrote some of the first descriptions of skin conditions. However, he classified psoriasis in the same category as leprosy (Hansens disease).
People continued to classify psoriasis in the same category as Hansens disease for several centuries, and as a result, people with psoriasis often experienced stigma and were outcasts from society.
During the Renaissance period, several people wrote books further categorizing skin conditions. Two Italian authors, Girolamo Mercuriale and Bernardino Ramazzini, began to describe different skin conditions, including psoriasis, in their books De Morbius Cutaneis and De Morbis Artificum.
In 1809, the English doctor Robert Willan also categorized skin conditions. He was the first person to provide a description of different types of psoriasis, and he wrote about the progression of the condition.
While Robert Willan was the first person to investigate psoriasis as a separate condition, he still used the term lepra vulgaris, which contributed to people associating psoriasis with leprosy.
In the 1800s, the Austrian physician Ferdinand von Hebra was the first to use modern research techniques to study skin conditions. He also removed lepra from the description of psoriasis.
During this century, French doctors discovered the connection between psoriasis and a form of arthritis called psoriatic arthritis.
Other medical professionals of the time continued to make discoveries that led to later research subcategorizing psoriasis. For example, Australian dermatologist William J. Munro discovered mico-abscesses in the top layer of the skin in people with this condition. Later research would find that these abscesses are part of psoriasis vulgaris, a common form of this condition.
Heinrich Kbner made an important discovery during the 19th century. He found that people with psoriasis may also develop psoriatic lesions in previously unaffected areas that have experienced trauma, such as a cut, burn, or bruise. Doctors still use the Kbner phenomenon as a diagnostic tool today.
The 20th century saw various advancements in the classification of psoriasis and its symptoms.
In 1910, Leo von Zumbusch was the first to describe pustular psoriasis, a rare type of psoriasis that causes pustules, blisters, fever, and fatigue.
In 1926, Dr. Woronoff discovered that people with psoriasis may have a pale ring of skin around healing lesions. This halo, or Woronoff ring, is another diagnostic tool that medical professionals use. The appearance of a Woronoff ring may be a sign that psoriasis lesions are healing.
In 1963, E. J. Van Scott found that people with psoriasis have a rapid turnover of cells, which is a marker of an autoimmune condition. This discovery that psoriasis is an autoimmune condition affected the way doctors treated this condition.
A 1973 paper by John M. Moll and Verna Wright linked psoriasis to psoriatic arthritis. This was one of the first research papers to distinguish psoriatic arthritis from rheumatoid arthritis.
The understanding that psoriasis is an autoinflammatory condition rather than a skin disease has led to advances in treatment. In auto-inflammatory conditions, the immune system attacks healthy tissue and cells in the body.
Within the last decade, discoveries in genetics and molecular science have led to a greater understanding of how psoriasis affects people. Researchers now know that the cause is a complex interaction between immunological, environmental, cellular, and genetic factors.
One of the earliest treatments for psoriasis was coal tar. Medical professionals may still recommend using coal tar as a first-line treatment in cases of mild plaque psoriasis. And they may recommend it in combination with other medications for cases of moderate or severe plaque psoriasis.
In the 1920s, William Goeckerman developed Goeckerman therapy, which combined UVB light with coal tar to treat psoriasis. Doctors still use this treatment today for moderate or severe psoriasis.
Throughout the 1900s, experts created several new treatments, such as:
Biologic drugs are the most recent development in the treatment of psoriasis. These drugs interrupt the immune process of the condition, which can help ease its symptoms. A 2018 study reports that biologics are highly effective and lead to dramatic improvements in 8090% of people with psoriasis.
Healthcare professionals may also prescribe topical and oral retinoids, such as acitretin (Soriatane). Experts are also investigating the effectiveness of Janus kinase (JAK) inhibitors, which healthcare professionals already use in the treatment of rheumatoid arthritis and psoriatic arthritis.
People have been aware of psoriasis for centuries and often grouped this condition with leprosy (Hansens disease). Over time, experts began to recategorize this condition and learn more about how it affects the body, eventually discovering it is an autoimmune condition.
Similarly, treatment has evolved over time to become more effective. There are now several options that a doctor may recommend, many of which were first discovered in the 1900s.
Posted: at 1:08 pm
Psoriasis can cause stress for someone with the condition due to difficulties managing symptoms, physical discomfort, or feelings of social embarrassment. Conversely, stress can also trigger psoriasis flares. Practicing self-care to improve mental health and reduce stress can help to reduce the chance of stress triggering further flares.
Psoriasis and stress share a symbiotic relationship of sorts, where each can cause and worsen the symptoms of the other.
Psoriasis is a type of immune-mediated disease where the immune system causes inflammation throughout the body.
While many people may associate the condition with scaly patches of skin, it can also cause issues in other areas of the body.
In addition, living with psoriasis can also affect a persons mental health. It may cause a person to feel stress relating to showing their skin, social situations, or caring for the condition.
Stress can then trigger a psoriasis flare or a worsening of symptoms. As a result, people living with psoriasis often benefit from managing both their physical and mental health.
Psoriasis can cause stress, and stress can cause psoriasis symptoms to worsen.
A 2018 review of studies looking at the link between psoriasis and stress notes that anywhere from 3188% of people living with psoriasis report stress as a trigger for their symptoms.
It also noted that, in addition to triggering flares, stress may also trigger the development of the condition itself in people predisposed to developing psoriasis.
How stress influences psoriasis is still not fully understood. According to an older study, one hypothesis, called the neurogenic inflammation hypothesis, states that psoriasis causes the release of neuropeptides, such as substance P (SP) and nerve growth factor (NGF).
These substances then cause local inflammation and result in the formation of psoriasis plaques. The hypothesis notes that stress releases high amounts of SP, which could then trigger the onset of the condition or flares.
When psoriasis plaques occur, it can cause stress for the person. The stress may relate to issues of embarrassment, the challenges of dealing with symptoms, discomfort, or a combination of different emotions.
The National Psoriasis Foundation recommends that all people living with psoriasis take steps to manage their stress as part of their treatment plan. They recommend a person:
According to a 2019 study, there is a link between alcohol intake and an increase in anxiety and depression. Therefore, a person may consider limiting their alcohol consumption to help minimize stress.
Before starting any new exercise programs, a person should talk with a doctor about what activities will be safe for them to perform.
Psoriasis is a lifelong condition characterized by periods of flares and remission. When treating psoriasis, a doctor will often suggest a combination of medications, therapies, mental health support, and lifestyle changes to help keep the condition under control.
Medical treatments may include:
Doctors may also recommend lifestyle changes that help manage symptoms and triggers. The American Academy of Dermatology Association (AAD) recommends a person take some steps to help manage their psoriasis at home:
In addition, a person should take measures to learn and avoid triggers. Triggers can vary from person to person but can include stress and weather changes.
By managing stress, a person may be able to help reduce psoriasis flares.
A person can consider the following general tips for managing stress, including:
Psoriasis triggers can vary from person to person. It is important for an individual to understand their triggers so that they can take steps to avoid them.
Some common triggers of psoriasis include:
Psoriasis and stress share a link both conditions can trigger the other.
Mental health treatment, including lifestyle changes such as physical exercise, can help prevent stress from triggering flares.
It can also help a person cope with the stress and other emotions that often accompany living with psoriasis.
Findings from Tufts Medical Center in Psoriatic Arthritis Reported (Coverage of Specialty Drugs for Psoriasis and Psoriatic Arthritis by Commercial…
Posted: at 1:08 pm
Health Policy and Law Daily
2022 JUN 02 (NewsRx) -- By a News Reporter-Staff News Editor at Health Policy and Law Daily -- Current study results on psoriatic arthritis have been published. According to news reporting out of Boston, Massachusetts, by NewsRx editors, research stated, Specialty medications provide effective treatment with limited adverse effects to patients with psoriasis and psoriatic arthritis; however, variable coverage and high costs often create a barrier to treatment for patients with commercial health insurance.
The news journalists obtained a quote from the research from Tufts Medical Center: We aimed to evaluate coverage of psoriasis and psoriatic arthritis specialty medications by commercial insurance companies. We compiled data regarding specialty drug coverage for psoriasis and psoriatic arthritis using Tufts Medical Center Specialty Drug Evidence and Coverage (SPEC) database and analyzed the data for any notable trends. The SPEC database lists coverage decisions for 158 specialty drugs by 17 of the largest US commercial health plans, as well as data regarding the types of evidence cited by these insurance plans when making coverage decisions. Our results showed that insurance plans tend to be more restrictive than the U.S. Food and Drug Association (FDA) label when covering medications for psoriasis and psoriatic arthritis. Furthermore, medications for psoriatic arthritis tended to be less restricted than for psoriasis, and medications were most commonly approved as second line agents for both indications.
According to the news reporters, the research concluded: Our analysis confirms that variability in insurance coverage exists for the indications of psoriasis and psoriatic arthritis.
For more information on this research see: Coverage of Specialty Drugs for Psoriasis and Psoriatic Arthritis by Commercial Insurance Companies. Journal of Psoriasis and Psoriatic Arthritis, 2022. The publisher for Journal of Psoriasis and Psoriatic Arthritis is SAGE Publications.
A free version of this journal article is available at https://doi.org/10.1177/24755303221101843.
Our news editors report that additional information may be obtained by contacting Christine Learned, Department of Dermatology, Tufts Medical Center, Boston, MA, United States. Additional authors for this research include Sara Alsukait, Kristin R Fiumara, Melissa Ortega, James D Chambers, David Rosmarin.
ORCID is an identifier for authors and includes bibliographic information. The following is ORCID information for the author of this research: David Rosmarin (http://orcid.org/0000-0003-2786-0708).
(Our reports deliver fact-based news of research and discoveries from around the world.)
ACELYRIN, INC., Affibody AB and Inmagene Biopharmaceuticals Announce Data from Global Phase 2 Trial of Izokibep in Patients with Psoriatic Arthritis…
Posted: at 1:08 pm
Data suggest efficacy over standard of care for the treatment of psoriatic arthritis
Izokibep was well-tolerated, having a safety profile consistent with previous studies and the IL-17A inhibitor therapeutic class
Supports hypothesis that izokibep offers greater efficacy with high potency and small size, as well as strategy of evaluating IL-17A inhibition's potential for transformative efficacy across many disease states
LOS ANGELES and SOLNA, Sweden, and SHANGHAI, June 3, 2022 /PRNewswire/ -- ACELYRIN, INC., Affibody AB and Inmagene Biopharmaceuticals today announced data from a 16-week, global, Phase 2 clinical trial of izokibep in 135 patients with psoriatic arthritis (PsA) presented by Frank Behrens, MD, Associate Professor of Medicine, Head of Rheumatology Clinical Research, University Hospital & Deputy Director Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Goethe-University Frankfurt, Germany and a founding member of the Group of Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), during a podium session at the 2022 European Alliance of Associations for Rheumatology (EULAR) Congress in Copenhagen.
The randomized double-blind, placebo-controlled, Phase 2 clinical trial evaluated the safety and efficacy of izokibep dosed 80 mg every two weeks (Q2W) or 40 mg Q2W, versus placebo Q2W, in adult patients with active PsA. The global study assessed various endpoints at 16 weeks including the American College of Rheumatology (ACR) response, the Leeds Enthesitis Index (LEI), the Psoriasis Area and Severity Index (PASI) score and Quality of Life via the Psoriatic Arthritis Impact of Disease (PsAID) questionnaire.
Izokibep 80 mg Q2W
Izokibep 40 mg Q2W
p-value for means
(% beyond MCID)
1FAS, observed data for LEI > 0 at baseline N=43 (32%) post-hoc analysis2FAS, observed data for psoriasis BSA 3% at baseline N=74 (55%) post-hoc analysis
"Psoriatic arthritis is a painful and debilitating inflammatory disease of the peripheral joints, skin, and nails, and it can also affect the spine," said Professor Behrens. "Furthermore, residual entheseal pain and inflammation,which occurs in up to 60% of patients, is associated with more severe disease, poorer quality of life and is considered one of the most significant unmet needs of psoriatic arthritis patients. The data presented at EULAR demonstrate there is potential opportunity for increased therapeutic efficacy in joints, entheseal pain and inflammation resolution and improved quality of life, all of which would be meaningful for patients living with psoriatic arthritis."
Izokibep was well-tolerated in the study, having a favorable safety profile consistent with that previously observed for izokibep and the IL-17A inhibitor therapeutic class. The most commonly reported AEs were injection site reaction and injection site erythema, the majority of which was mild.
"The improvements demonstrated in arthritis, psoriasis and enthesitis are exciting relative to responses reported for the current standard of care," observed Professor Peter Taylor, Norman Collison chair of musculoskeletal sciences at the University of Oxford. "Combined with theclinically meaningful improvement in disease-specific quality of life and well-tolerated safety profile, izokibep seemspromising for patients living with the painful and debilitating symptoms of psoriatic arthritis, and I am eager to see its continued development for patients."
ACELYRIN holds worldwide rights to izokibep except development and commercialization rights by Inmagene in selected Asian countries, including China, Hong Kong, South Korea, and Taiwan, and excluding Japan. Affibody holds commercialization rights in the Nordic countries.
To date, more than 300 patients many for up to three years have received izokibep, a unique, antibody mimetic, interleukin-17A (IL-17A) inhibitor designed to overcome the limitations of monoclonal antibodies. With high potency and small molecular size, izokibep can reach high drug exposure levels through a single, subcutaneous injection that monoclonal antibodies require IV administration to achieve. Additionally, the small size of izokibep about one tenth the size of a monoclonal antibody enables its potential to reach targeted tissues that may otherwise be inaccessible to the much larger monoclonal antibodies.
About Psoriatic Arthritis
Psoriatic arthritis (PsA) is a chronic, immune-mediated inflammatory musculoskeletal condition affecting the peripheral joints, the skin (with psoriasis), the nails, and in approximately 30 percent of individuals, the spine. Left under-treated, PsA leads to chronic joint pain, swelling, and damage with a high potential for permanent disability. Psoriatic arthritis pathology is dominated by pro-inflammatory T-helper (Th-17) cells that lead to over expression of IL-17, IL-23, and TNF cytokines.
ACELYRIN, INC. is a Los Angeles area-based biopharma company focused on providing patients life-changing new treatment options by identifying, acquiring, and accelerating development and commercialization of promising drug candidates and leveraging its expertise to rapidly advance these medicines to patients. For more information, please visit http://www.acelyrin.com
About Affibody AB
Affibody AB is a clinical-stage biopharmaceutical company with a broad product pipeline focused on developing innovative bi- and multi-specific next generation biopharmaceuticals based on its unique proprietary technology platforms: Affibody molecules and Albumod. Affibody is a holding of Patricia Industries. For more information, please visit http://www.affibody.com
About Inmagene Biopharmaceuticals
Inmagene Biopharmaceuticals, with wholly owned subsidiaries in San Diego, Shanghai, Hangzhou, and Wuhan, is a leading biotech company focused on immunology-related therapeutic areas. Believing in "borderless innovation", the Inmagene team integrates efficient resources worldwide to develop drugs for patients globally. Inmagene is operating twelve "Smart Innovation" programs to create and develop novel drug candidates for the global market. For more information, please visit http://www.inmagenebio.com
This press release contains forward-looking statements. While ACELYRIN, INC., Affibody AB, and Inmagene Biopharmaceuticals consider the projections to be based on reasonable assumptions, these forward-looking statements may be called into question by numerous hazards and uncertainties, so that actual results may differ materially from those anticipated in such forward-looking statements.
View original content:https://www.prnewswire.com/news-releases/acelyrin-inc-affibody-ab-and-inmagene-biopharmaceuticals-announce-data-from-global-phase-2-trial-of-izokibep-in-patients-with-psoriatic-arthritis-presented-during-2022-european-alliance-of-associations-for-rheumatology-congress-301560613.html
SOURCE ACELYRIN, INC.
Kim Kardashian fans shocked after they see what her hands really look like in new pics… – The US Sun
Posted: at 1:08 pm
FANS of Kim Kardashian have long debated why the reality star is so often spotted covering her hands with various types of gloves when she goes out.
Now, they may have their answer, as the SKIMS founder was recently snapped with her hands bare, which appeared old and wrinkled.
In a series of new pictures, Kim was seen exiting a car. As she braced herself with her left hand, photos revealed her thin and bony frame.
On Reddit, fans were shocked by what they saw.
"Her skin looks like paper!" one fan exclaimed, as another added: "Where are the gloves when you need'em?!"
Still, one pointed out: "Hands tend to show age first, but she is also thin which lends itself to more visible blood vessels and tendons."
And another pointed out: "Doesnt she have psoriasis? Topical corticosteroids can cause the skin to become thin and age quickly."
Indeed, the 41-year-old has been open about herbattle with psoriasis, a skin disease that causes red, itchy, scaly patches.
The flare-ups most commonly occur on the knees, elbows, trunk, and scalp.
TheKeeping Up With the Kardashiansalum revealed she first began to deal with psoriasis in her mid-20s.
In an article for her sisterKourtneysbrandPoosh, Kim wrote: When I was 25, I had my first psoriasis flare-up.
I got a common cold, and since psoriasis is an autoimmune condition, this triggered it. It was all over my stomach and legs.
She continued: "Luckily, in my apartment complex at the time, my neighbor was a dermatologist. I showed it to him, and he said to come into the office, and he would give me a shot of cortisone, and then hopefully, it would go away (since it was my first big outbreak).
"I did this, and my psoriasis completely went away for about five years.
KardashianmatriarchKris Jenner, 66, also has psoriasis, though Kim was her only child to inherit the condition.
Kim explained in the Poosh story that her psoriasis returned when she was in her early 30s.
The model is currently celebrating the release of her newhigh-end skincare linecalled SKKN.
As part of the launch, she has admitted that her beauty "is not natural" and would take hours of work each morning, including stem cell facials and lasers.
In an interview with the New York Times, The Kardashiansstar explained she has a nine-step system that "might seem scary to some."
She added: "Thats why Im here to break it down, to be like, Theyre all necessary."
The Hulu star then dived into her appearance and revealed: "So many people want to act like they dont care about how they look.
"Im not acting like it comes easier or its all-natural. You just dont wake up and use whatever. You wake up, you use ingredients.
While using her SKKN samples, theKeeping Up With the Kardashiansalum demonstrated her lengthy routine.
She headed off to the bathroom and washed her face to remove the makeup from a previous photo shoot.
As part of her skincare routine, Kim cleansed, exfoliated, and patted her face with a combination of glow oil and face cream.
She concluded: I always go down to my chest - down to my nipples always down to nips.
We pay for your stories!
Do you have a story for The US Sun team?
Posted: at 1:07 pm
Artificial intelligence (AI) tool can drastically reduce diagnostic time for psoriatic arthritis patients, welcomes the educated community in a press release.
Its primarily dermatologists who treat patients with psoriasis and we have the opportunity to ask them about potential joint pain because about 10% of them may have osteoarthritis but without knowing it, recalls lead author Dr. Jonathan Shapiro of McCabe Health Services. The statement was quoted by Ramat Hasharon.
Since patients do not always associate joint pain with skin problems, they will talk to their general practitioner or orthopedic surgeon. But the latter can miss a psoriatic arthritis diagnosis because these symptoms are not very specific, leading to delayed care and risks of irreversible lesions and disability, he continues.
In this retrospective study, Dr. Shapiro and colleagues discover ways to recognize early
To access the rest of the article, you must accept performance and tracking cookies. It allows us to anonymously aggregate statistics that we share with our advertisers. Thanks to advertising, this site is funded and the articles written by our journalists are available to you for free.
To change your cookie settings, Press here.
Did you like this article?
Subscribe to our newsletter and receive weekly digital news from the health industries
Subtly charming problem solver. Extreme tv enthusiast. Web scholar. Evil beer expert. Music nerd. Food junkie.
Go here to see the original:
Artificial intelligence could shorten the diagnosis of psoriatic arthritis - Vaughan Today
Posted: at 1:06 pm
United States of AmericaUS Virgin IslandsUnited States Minor Outlying IslandsCanadaMexico, United Mexican StatesBahamas, Commonwealth of theCuba, Republic ofDominican RepublicHaiti, Republic ofJamaicaAfghanistanAlbania, People's Socialist Republic ofAlgeria, People's Democratic Republic ofAmerican SamoaAndorra, Principality ofAngola, Republic ofAnguillaAntarctica (the territory South of 60 deg S)Antigua and BarbudaArgentina, Argentine RepublicArmeniaArubaAustralia, Commonwealth ofAustria, Republic ofAzerbaijan, Republic ofBahrain, Kingdom ofBangladesh, People's Republic ofBarbadosBelarusBelgium, Kingdom ofBelizeBenin, People's Republic ofBermudaBhutan, Kingdom ofBolivia, Republic ofBosnia and HerzegovinaBotswana, Republic ofBouvet Island (Bouvetoya)Brazil, Federative Republic ofBritish Indian Ocean Territory (Chagos Archipelago)British Virgin IslandsBrunei DarussalamBulgaria, People's Republic ofBurkina FasoBurundi, Republic ofCambodia, Kingdom ofCameroon, United Republic ofCape Verde, Republic ofCayman IslandsCentral African RepublicChad, Republic ofChile, Republic ofChina, People's Republic ofChristmas IslandCocos (Keeling) IslandsColombia, Republic ofComoros, Union of theCongo, Democratic Republic ofCongo, People's Republic ofCook IslandsCosta Rica, Republic ofCote D'Ivoire, Ivory Coast, Republic of theCyprus, Republic ofCzech RepublicDenmark, Kingdom ofDjibouti, Republic ofDominica, Commonwealth ofEcuador, Republic ofEgypt, Arab Republic ofEl Salvador, Republic ofEquatorial Guinea, Republic ofEritreaEstoniaEthiopiaFaeroe IslandsFalkland Islands (Malvinas)Fiji, Republic of the Fiji IslandsFinland, Republic ofFrance, French RepublicFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabon, Gabonese RepublicGambia, Republic of theGeorgiaGermanyGhana, Republic ofGibraltarGreece, Hellenic RepublicGreenlandGrenadaGuadaloupeGuamGuatemala, Republic ofGuinea, RevolutionaryPeople's Rep'c ofGuinea-Bissau, Republic ofGuyana, Republic ofHeard and McDonald IslandsHoly See (Vatican City State)Honduras, Republic ofHong Kong, Special Administrative Region of ChinaHrvatska (Croatia)Hungary, Hungarian People's RepublicIceland, Republic ofIndia, Republic ofIndonesia, Republic ofIran, Islamic Republic ofIraq, Republic ofIrelandIsrael, State ofItaly, Italian RepublicJapanJordan, Hashemite Kingdom ofKazakhstan, Republic ofKenya, Republic ofKiribati, Republic ofKorea, Democratic People's Republic ofKorea, Republic ofKuwait, State ofKyrgyz RepublicLao People's Democratic RepublicLatviaLebanon, Lebanese RepublicLesotho, Kingdom ofLiberia, Republic ofLibyan Arab JamahiriyaLiechtenstein, Principality ofLithuaniaLuxembourg, Grand Duchy ofMacao, Special Administrative Region of ChinaMacedonia, the former Yugoslav Republic ofMadagascar, Republic ofMalawi, Republic ofMalaysiaMaldives, Republic ofMali, Republic ofMalta, Republic ofMarshall IslandsMartiniqueMauritania, Islamic Republic ofMauritiusMayotteMicronesia, Federated States ofMoldova, Republic ofMonaco, Principality ofMongolia, Mongolian People's RepublicMontserratMorocco, Kingdom ofMozambique, People's Republic ofMyanmarNamibiaNauru, Republic ofNepal, Kingdom ofNetherlands AntillesNetherlands, Kingdom of theNew CaledoniaNew ZealandNicaragua, Republic ofNiger, Republic of theNigeria, Federal Republic ofNiue, Republic ofNorfolk IslandNorthern Mariana IslandsNorway, Kingdom ofOman, Sultanate ofPakistan, Islamic Republic ofPalauPalestinian Territory, OccupiedPanama, Republic ofPapua New GuineaParaguay, Republic ofPeru, Republic ofPhilippines, Republic of thePitcairn IslandPoland, Polish People's RepublicPortugal, Portuguese RepublicPuerto RicoQatar, State ofReunionRomania, Socialist Republic ofRussian FederationRwanda, Rwandese RepublicSamoa, Independent State ofSan Marino, Republic ofSao Tome and Principe, Democratic Republic ofSaudi Arabia, Kingdom ofSenegal, Republic ofSerbia and MontenegroSeychelles, Republic ofSierra Leone, Republic ofSingapore, Republic ofSlovakia (Slovak Republic)SloveniaSolomon IslandsSomalia, Somali RepublicSouth Africa, Republic ofSouth Georgia and the South Sandwich IslandsSpain, Spanish StateSri Lanka, Democratic Socialist Republic ofSt. HelenaSt. Kitts and NevisSt. LuciaSt. Pierre and MiquelonSt. Vincent and the GrenadinesSudan, Democratic Republic of theSuriname, Republic ofSvalbard & Jan Mayen IslandsSwaziland, Kingdom ofSweden, Kingdom ofSwitzerland, Swiss ConfederationSyrian Arab RepublicTaiwan, Province of ChinaTajikistanTanzania, United Republic ofThailand, Kingdom ofTimor-Leste, Democratic Republic ofTogo, Togolese RepublicTokelau (Tokelau Islands)Tonga, Kingdom ofTrinidad and Tobago, Republic ofTunisia, Republic ofTurkey, Republic ofTurkmenistanTurks and Caicos IslandsTuvaluUganda, Republic ofUkraineUnited Arab EmiratesUnited Kingdom of Great Britain & N. IrelandUruguay, Eastern Republic ofUzbekistanVanuatuVenezuela, Bolivarian Republic ofViet Nam, Socialist Republic ofWallis and Futuna IslandsWestern SaharaYemenZambia, Republic ofZimbabwe
Originally posted here:
Posted: at 1:04 pm
May 31, 2022
John Waters has been called many things: the Prince of Puke, the Peoples Pervert, the Pope of Trash. But, above all, hes a storyteller. For nearly 60 years hes offered a uniquely subversive form of social commentary by bulldozing through contemporary notions of American good taste. No other film director would devise a scene where an outrageous reprobate played by the greatest drag queen of all Waters longtime collaborator Divine eats an actual dog poo. But Waters did this in his 1972 cult classic Pink Flamingos, and never looked back.
By the time he made 1988s big-hearted comedy Hairspray, Waters was inching ever closer to mainstream success. Hairspray has since been adapted into an enormously successful Broadway musical and glossy Hollywood blockbuster that put John Travolta in the dragged-up role originated by Divine. Its safe to presume no Hollywood remake of Pink Flamingos is coming any time soon.
Now 76, Baltimore-based Waters continues to move with the times by sending them up in his own transgressive way. Hes recently published his debut novel Liarmouth, a gloriously sordid romp about an amoral femme fatale who makes her living by swiping suitcases from airports. The fact Waters gives his antiheroine an almost cutesy-sounding name Marsha Sprinkle only makes her more shocking.
Hes also bringing his latest spoken-word show, False Negative, to London's Barbican Hall for back-to-back Friday night shows on June 10. If its anything like this interview, you can expect observations that are pin-sharp, articulate, and playfully provocative at all times.
Nick Levine: What are your main targets in False Negative?
John Waters: When you say targets, that means that you think Im attacking. Actually, I make fun of the things I love. Its a little bit of an attack. It is [me] trying to understand the new rules of every outlaw society Ive ever lived in since the moment I first rebelled, which is probably the first time I heard Elvis Presley sing. Im also giving you a humorous take on how the world has completely changed since Covid: how humour has changed, fashion has changed, sex has changed, everything.
NL: Do you feel as though you can make fun of anything, as long as you have the right intentions?
JW: I think you have to be extra careful. I dont do a lot of Holocaust jokes when Im not Jewish. I dont do a lot of African American jokes. But good humour has always walked that ledge of what you can get away with. I make fun of things I love, and I think thats what has enabled me to get away with this for 50 years.
NL: Youve also just published a brilliantly irreverent novel, Liarmouth. Do you think the line of what you can get away with is different in a spoken-word show? Can you get away with more because its in the moment?
JW: When you say anything out loud in a show, one reporter can write it down [and publish it] out of context. And that thing can be more remembered than a whole book. But they have the right to do that, so you have to watch what you say. There are lines in Liarmouth that certainly go over that edge of what you can get away with, but so far I think people are reading it in the exact same tone that I give everything. They get it. My fans have helped me all of these years because they are angry and they have a good sense of humour. They can laugh at themselves and the seriousness of their peers [political] battles.
I make fun of things I love, and I think thats what has enabled me to get away with this for 50 years John Waters
NL: Liarmouth's lead character, Marsha Sprinkle, is wonderfully appalling. Has she been living inside you for some time?
JW: Well, I think she would be able to get along with Serial Mom or Dawn Davenport [Divines character in Female Trouble]. I think that she would feel comfortable in my world, certainly. But she was a character that I totally made up as somebody who would be different from what political correctness is today, and different to anything my friends feel. I dont know anyone that could hate their body as much as Marsha. Even defecation infuriates her because she didnt get to think it up. She tries to kill her need to defecate by only eating crackers so she can just shoot out little pellets. I know what she means; I wish I didnt have to do that every day, too.
NL: The book also features a character who performs plastic surgery on pets, which feels like the kind of ridiculous thing that actually could happen.
JW: I bet that is already is happening in Los Angeles or Monaco, where people would want their dogs to look rich. I look at some people [whove had work done] and think: Did they want to look like that? And my friend Pat Moran says: No, they want to show theyre rich by proving they can afford to have a facelift. Its the opposite of what Id want if I ever had a facelift. Id go to Switzerland where it would be underplayed.
NL: I read an interview with a British celebrity who said she doesnt have work done because it makes her look younger, but because it makes her look fashionable. For her, its a status symbol.
JW: For me, its the opposite. Though I tell ya, Deborah Harry had it and she talks about it all the time and she looks great. She is a great star, so Im not saying everybody shouldnt do it. But I think I probably got asked to appear in the new Calvin Klein campaign because I do look old. I talk in my show about why you shouldnt get plastic surgery, and bring up a lot of celebrities that never would have had a career if theyd gotten it.
I think every drag queen now has been influenced by Divine: almost none of them are square like they were when we were growing up. Back then, they all wanted to be Miss America John Waters
NL: Drag has changed so much in the last 15 years: partly because of RuPaul's Drag Race, and partly because of social media. Do you think it can still be genuinely subversive?
JW: Well, I think it is more accepted than its ever been. And I give RuPaul great credit for that. I think every drag queen now has been influenced by Divine: almost none of them are square like they were when we were growing up. Back then, they all wanted to be Miss America. Now they all have an attitude, they have an act, and they have a certain rage in them. To me, drag kings do that better sometimes now, because they can sometimes pass even better [as the gender theyre sending up] and that makes them scarier to people. And so I think there still is a way for drag to surprise people.
NL: Do you ever think of where Divine might slot in now, or is that almost too weird?
JW: He would be on the show as a judge and he would be a man. Divine was not trans: he had no desire to be a woman, though he would be for the [trans] movement and the freedom of it. But Divine was an actor; towards the end [of his life] he wore expensive mens clothes. And one thing Divine was really struggling on, that RuPaul has figured out more than anyone, was to have a great look as a man, too. Thats really important, I think. If youre going to be a celebrity drag queen, you have to have both looks down. But Divine changed things [back in the day] because he would go to drag concerts with a chainsaw and scars on his face. Other drag queens hated him because they knew he was making fun of drag, but in a new way, and especially because he was overweight. No other drag queen was like that at the time.
NL: We have this expression in the UK: national treasure. At this stage in your career, do you ever feel like a kind of alternative national treasure?
JW: National treasure? That expression makes me think of April Ashley. Well, I would never brag like that. But when people come up to me and say I saved their lives or made them feel good about themselves when they were younger, Im amazed. And Im really honoured that I did that. But I just try not to feel too much like a twisted Mother Teresa.
John Waters will be performing his all-new, stand-up comedy monologue False Negative at Londons Barbican Hall on June 10. His novel Liarmouth is out now.
Posted: at 1:04 pm
To the editor:
I am happy to announce that this letter is now being circulated throughout the entire country of Ukraine and Russia. Every government, church, bank, university and many other institutions have been emailed.
The feedback is overwhelming. The Ukrainians are ready to defend themselves, and the Russians want no part of this war.
This letter is in response to the articles covering the invasion of Ukraine by Russia.
As a citizen of and believer in democracy, I applaud the efforts of the Ukrainian people. Their efforts are similar to what is happening in many other parts of the world. Believe it or not, one thing that overrides capitalism and political correctness in the United States is the right to have ones voice heard. This is the foundation of which our democracy is built on.
The Ukrainian people should continue to defy Vladimir Putins powerful armed forces so that Ukrainian democracy can continue to thrive. It is unfortunate that the United States compromised on one of its most fundamental values in order to protect its economic interests in Eastern Europe something that happens all too often domestically as well.
It is not the Ukrainian people who are attempting to expand NATO power, but rather it is Vladimir Putin who has engaged in intimidation to prevent the will of the people both Ukrainian and Russian from being heard. Why else would he stoop to such underhanded tactics to block various means of communication among the citizens of Ukraine and Russia?
Why is Putin forcing Russia to return to the Cold War, utilizing political strong-arm tactics such as violence?
Vladimir Putin, you have had more than 20 years to acknowledge Ukraine and have failed them by your own choosing. The days of your despotic regime are finally coming to an end as it appears the desire for freedom will continue to sweep among the Eastern European nations, as well as Russia.
Accordingly, let the call go forth among all citizens of Ukraine that your brothers and sisters of democracy from all over the world are with you during every trial and tribulation you may encounter during this crisis. To the people of Ukraine, the trumpet of freedom beckons you to rise in protest and louden your voice to preserve your sacred heritage, promote your childrens future, and obtain the blessings of liberty we all cherish.
Ukraine, the hour of your redemption is at hand. As you the rightful citizens move forward to reclaim your own country, rise and strike! In the name of those who were murdered fighting for everyones rights, rise and strike! To push back this evil regime, rise and strike!
Let no one continue to fear this man. Every Ukrainian must be strong and fight on for their freedom.
Rise and strike!
Vladimir Putin, you little weasel let Ukraine go!
Read more from the original source:
Posted: at 1:04 pm
As the Republican party primaries play out across the US, the most sought after endorsement is still that of former president Donald Trump. But when it comes to the most vital part of any American campaign money another figure is emerging on the right of US politics who is becoming equally significant.
Peter Thiel, the PayPal founder and former CEO referred to as the don of the original PayPal Mafia, a group that included Elon Musk, is establishing himself as a serious power player in American rightwing politics by wielding the power of his vast fortune.
Thiel, styled as a billionaire venture capitalist and tech entrepreneur, plowed more than $10m into a super Pac backing Hillbilly Elegy author JD Vance, winner of the Republican primary for an open US Senate seat in Ohio.
In August, Thiels backing will be tested again after shoveling $13.5m into supporting former employee Blake Masters in the competitive Republican primary for a US Senate seat in Arizona.
In both cases, Thiel put his money his fortune is said to be in the region of $6bn to work behind candidates aligned with Trumps rightwing agenda in 2022 midterm elections.
Earlier this year Thiel stepped down from the board of Meta, where he was an early investor, and a long-serving adviser to CEO Mark Zuckerberg. He wanted to avoid being a distraction for Facebook, according to a person close to Thiel. With his resignation effective this month, the source told Forbes Thiel thinks that the Republican Party can advance the Trump agenda and he wants to do what he can to support that.
But there is a vacuum between the entire Trump political agenda and Trump himself. The former president is apt to pick candidates who promote his stolen election claims. Not all succeed, or are likely to. Trumps failed backing of David Perdue as Georgias Republican gubernatorial candidate looked like a personal grudge against incumbent Brian Kemp, who certified Bidens victory in 2020.
Thiel has so far helped Trump in that cause. By some estimates, Thiel has donated $25m to 15 other 2022 candidates for the House and Senate towing the Trump election fraud line.
Max Chafkin, author of a Thiel biography The Contrarian, recently wrote that Thiels goal is to turn Trumps ideology into a disciplined political platform.
For Thiel, endorsements of Vance and Masters follow a $300,000 donation to the campaign of far-right senator Josh Hawley, then running for Missouri attorney general in 2016. He also donated money to help elect Trump president and spoke on his behalf at the Republican National Convention.
Thiel stayed out of the 2020 presidential race, and instead donated $2.1m to a super Pac supporting Kris Kobach, the Kansas secretary of state who had proposed creating a registry of Muslim immigrants and visitors.
Thiel is one of the conservative mega donors that has the ability to shore up candidates that might need additional support. His spending is targeted, and his ability to spend millions can be impactful, said Sheila Krumholz at OpenSecrets.
Where Trump often seems a single issue political player obsessed with the 2020 election loss Thiel is more flexible in terms of what he represents, Krumholz says.
Often when youre talking about party-aligned mega donors, there are people who have been active over decades, so Peter Thiel strikes a different figure. Hes an entrepreneur, hes tech industry, super successful, seen as part of the young conservative vanguard that some see as more libertarian.
They might be Trump supporters, but their portfolio and persona waters down the connection, Krumholz adds.
Like Musk, Thiel called The Dungeon Master by the New York Review of Books because he played Dungeons & Dragons as a teenager and read J R R Tolkiens trilogy ten times presents a contradictory picture.
As an undergraduate, he founded the conservative Stanford Review and in 1995 Thiel co-authored The Diversity Myth, a book sought to question the impact of multiculturalism and political correctness at Californias higher education campuses.
In bright and shallow Silicon Valley, Thiel stands apart for having retained the intellectual intensity of a bookish undergraduate, a quality that has made him an object of curiosity, admiration and mockery, the publication noted. He stands apart amid the orthodoxy of tech-world social progressivism as much for his conservatism as for his business sense.
In 2003, he co-founded Palantir Technologies, a firm to assist US intelligence agencies with counter-terrorism operations. Last week, Palantir and global commodities trader Trafigura announced a new target market to track carbon emissions for the oil, gas, refined metals and concentrates sector. BP is among its customers, Reuters reported.
Thiels libertarian credentials, and perhaps in part his political motivation, were publicly established in 2016 when he funded an invasion of privacy lawsuit filed by Terry Bollea, known more popularly as wrestler Hulk Hogan, that bankrupted the news website Gawker. Gawker had outed Thiel in 2007.
Its less about revenge and more about specific deterrence, Thiel said of the action. I saw Gawker pioneer a unique and incredibly damaging way of getting attention by bullying people even when there was no connection with the public interest I thought it was worth fighting back.
Funding the lawsuit, he added, was one of the greater philanthropic things that Ive done.
Blake Masters, the 35-year-old Republican US senate candidate for Arizona, has suggested he would use the same tactics after the Arizona Mirror wrote that the candidate opposes abortion rights and wants to allow states to ban contraception use. Masters denies those positions.
If I get any free time after winning my elections then youre getting sued, and Ill easily prove actual malice, Masters wrote in a tweet. Gawker found out the hard way and you will too.
Thiel, said Masters last year, sees some promise in me, but he knows Ill be an independent-minded senator.
But the larger issue for Thiel may be intense cross-currents in the US around big tech, social media and free speech. His former PayPal Mafia consigliere, Musk, is also emerging from the tech world to have influence in US politics where he recently declared himself a Republican and free speech as he seeks to buy the social media platform Twitter.
[Tech is] an industry on the cutting edge and caught in the cross-fire between the parties, said Krumholz. There are a lot of conflicting pressures on and from within the tech industry. Tech is being scapegoated by some, and held responsible for much of the disinformation, excesses of social media, partisan division and radicalization we see.
Moira Weigel, a professor of communications at Northeastern University and a founding editor of Logic magazine, argued in the New Republic last year that Thiel does not really matter: What matters about him is whom he connects.
At the moment, Thiel is busy connecting some of the most rightwing politicians in recent US history.
View original post here: