Monthly Archives: March 2021

Tomi Lahren on Cuomo: ‘Democrats only go after their own’ to ‘distract from other Democrat wrongdoings’ – Fox News

Posted: March 16, 2021 at 3:06 am

Fox Nation host Tomi Lahren weighed in Monday on the scandals surrounding New York's "narcissistic tyrant",Gov. Andrew Cuomo, after a seventh accuser came forward with claims of sexual misconduct over the weekend.

Despite multipleinvestigations and growing calls from members of his own party to resign, Cuomo has refused to leave office, telling reporters on Friday that Democrats pressuring him to do so don't know the difference between "playing politics, bowing to cancel culture, and the truth."

"Cancel culture is not what happens to an elected official after he or she sends thousands of seniors to an early grave, covers it up, and/or allegedly sexually harasses and intimidates women. So dont get it twisted, bud," Lahren told viewers on her Fox Nation show "Final Thoughts."

The host said shewas "amazed" at Cuomo's ability to "play the victim," and wondered whether Democrats were focused on the harassment claimsas a deliberate attempt to distract from "the thousands of seniors sent to an early grave thanks to the poor decision-making of Governor Cuomo and other governors with "Ds" behind their names."

BIDEN BREAKS HIS SILENCE ON CUOMO SCANDALS

"What about the timing? The sexual allegations may have surfaced rather recently, but the nursing home debacle has been public knowledge for months and prior to the election. The Democrats shirked that off leading up to November because Cuomos deathly leadership decisions did not supersede or exceed his 'gold standard'hatred for Donald Trump."

Lahren observed that whilePresident Joe Biden addressed the scandal for the first time Sunday night, Vice President Kamala Harris -- who was a vocal supporter of Christine Blasey Ford during the 2018 Supreme Court confirmation ofBrett Kavanaugh-- has maintained her silence on the mounting allegations.

ANDREW CUOMO'S ACCUSERS: WOMEN WHO HAVE MADE CLAIMS AGAINST THE NEW YORK DEMOCRAT

"Well, Kamala, what say you?" Lahren said. "Wheres the passion, the fire, the outrage, the justice when it comes to a powerful Democrat accused by several women of sexual harassment and inappropriate behavior? Really looking forward to your commentary on the matter given your likely faux outrage over similar accusations levied against conservatives in the past."

"The moral of the story here is this," concluded Lahren. "Democrats only go after their own if it can somehow distract from other Democrat wrongdoings and/or benefit their collective party in a way that exceeds their loyalty to fellow libs."

To watch Lahren's latest episode of"Final Thoughts,"and for more exclusive commentary,visit Fox Nationand join today.

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Tomi Lahren on Cuomo: 'Democrats only go after their own' to 'distract from other Democrat wrongdoings' - Fox News

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How Democrats Hope to Press Their Advantage on the Stimulus – The New York Times

Posted: at 3:06 am

President Biden signed his $1.9 trillion coronavirus relief bill into law yesterday, a move that will send $1,400 stimulus checks to many Americans, strengthen a wide range of social programs and step up investment in vaccine distribution. A few hours later, he went on national television to trumpet the achievement. And this afternoon, he celebrated it in a Rose Garden ceremony, joined by Democratic leaders in Congress.

It changes the paradigm, Biden said today, talking about the plans provisions to support low- and middle-class workers. For the first time in a long time, this bill puts working people in this nation first.

The bill passed without any Republican votes, depriving the Biden administration of the ability to frame it as a bipartisan effort but also denying the G.O.P. the chance to reap its rewards in the realm of public opinion, if the legislation remains as popular as it is right now, according to polls.

Biden is planning to travel the country in the coming days to drive home the message to Americans that the legislation doesnt just provide needed relief to families and businesses but also that Democrats have delivered on a key campaign promise. Will it resonate? Come the 2022 midterm elections, will voters remember a law that was passed a year and a half earlier?

To understand how the policy interacts with the politics, I caught up with Jonathan Martin, a national political correspondent, to talk about how Democrats plan to marshal this legislative victory to their advantage at the ballot box next year.

Republican lawmakers in Washington were unified in their opposition to the relief package. But some, like Senator Roger Wicker of Mississippi, are already praising some of the programs that the bill has funded. Are any of those G.O.P. lawmakers regretting their opposition?

The popularity of the package isnt lost on congressional Republicans. Some in the party believe it will become less appealing once voters realize how little of the funding is for direct Covid relief, but most G.O.P. lawmakers seem eager to change the subject to the growing number of migrants on the southern border.

Its no accident that the House Republican leader, Kevin McCarthy, is headed there on Monday (and not planning to hold events in opposition to the stimulus).

Biden has talked about learning lessons from 2009, when then-President Barack Obama signed a nearly $1 trillion stimulus bill but resisted taking a victory lap. Democrats ended up suffering big losses in the 2010 midterms. How is Biden seeking to avoid a similar fate?

With a lot of events! Im only half-kidding.

The White House is determined to flood the zone, as the saying goes, and dispatch all manner of figures, from the first and second families to cabinet secretaries, to promote the bill.

But the administration also hopes that the direct impact namely checks in the mail will make this measure a lot more tangible and therefore politically popular than the 2009 bill.

If Democrats were able to retain their razor-thin majorities in Congress, it would fly in the face of history which tells us that a new presidents party hardly ever comes out on top in the midterm elections. Looking at the map in 2022, how good do Democrats think their chances are of defying that history?

Right now, they are optimistic because theyre united certainly by Democratic standards! and Republicans have obvious challenges with former President Donald Trump, whos still liked by their primary base but is deeply unpopular with the broader electorate.

But Democratic leaders know how often theres a backlash to the party in power, and they also know how tight their margins are in both chambers of Congress. Even the slightest pro-Republican breeze next year will lift them to the majority.

Thestimuluspayments would be $1,400 for most recipients. Those who are eligible would also receive an identical payment for each of their children. To qualify for the full $1,400, a single person would need an adjusted gross income of $75,000 or below. For heads of household, adjusted gross income would need to be $112,500 or below, and for married couples filing jointly that number would need to be $150,000 or below. To be eligible for a payment, a person must have a Social Security number. Read more.

Buying insurance through the government program known as COBRA would temporarily become a lot cheaper. COBRA, for the Consolidated Omnibus Budget Reconciliation Act, generally lets someone who loses a job buy coverage via the former employer. But its expensive: Under normal circumstances, a person may have to pay at least 102 percent of the cost of the premium. Under the relief bill, the government would pay the entire COBRA premium from April 1 through Sept. 30. A person who qualified for new, employer-based health insurance someplace else before Sept. 30 would lose eligibility for the no-cost coverage. And someone who left a job voluntarily would not be eligible, either. Read more

This credit, which helps working families offset the cost of care for children under 13 and other dependents, would be significantly expanded for a single year. More people would be eligible, and many recipients would get a bigger break. The bill would also make the credit fully refundable, which means you could collect the money as a refund even if your tax bill was zero. That will be helpful to people at the lower end of the income scale, said Mark Luscombe, principal federal tax analyst at Wolters Kluwer Tax & Accounting. Read more.

There would be a big one for people who already have debt. You wouldnt have to pay income taxes on forgiven debt if you qualify for loan forgiveness or cancellation for example, if youve been in an income-driven repayment plan for the requisite number of years, if your school defrauded you or if Congress or the president wipes away $10,000 of debt for large numbers of people. This would be the case for debt forgiven between Jan. 1, 2021, and the end of 2025. Read more.

The bill would provide billions of dollars in rental and utility assistance to people who are struggling and in danger of being evicted from their homes. About $27 billion would go toward emergency rental assistance. The vast majority of it would replenish the so-called Coronavirus Relief Fund, created by the CARES Act and distributed through state, local and tribal governments,accordingto the National Low Income Housing Coalition. Thats on top of the $25 billion in assistance provided by the relief package passed in December. To receive financial assistance which could be used for rent, utilities and other housing expenses households would have to meet severalconditions. Household income could not exceed 80 percent of the area median income, at least one household member must be at risk of homelessness or housing instability, and individuals would have to qualify for unemployment benefits or have experienced financial hardship (directly or indirectly) because of the pandemic. Assistance could be provided for up to 18 months,accordingto the National Low Income Housing Coalition. Lower-income families that have been unemployed for three months or more would be given priority for assistance. Read more.

In his speech last night, Biden said the vaccine rollout was truly a national effort, just like we saw during World War II. After a presidential campaign centered on calls for unity and reconciliation, does Biden see this bill which is supported by about seven in 10 Americans, according to polls as an opportunity to actually hark back to an era of American history before political polarization took hold so deeply?

Thats certainly how he campaigned, and in the first days of his administration he seemed to be interested in pursuing bipartisanship. But when Senate Republicans came to him with a counteroffer on the stimulus that was about a third of the $1.9 trillion he had in mind, he chose speed and scale over bipartisanship.

The big question, now that Congress seems to be moving to infrastructure, historically an issue that transcends party lines, is whether Biden will make a real turn toward true bipartisanship and push congressional Democrats to put together a package that includes Republicans.

New York Times Podcasts

On todays episode, Ezra spoke with Dr. Ashish Jha, a physician, leading health policy researcher and dean of the Brown University School of Public Health.

Dr. Jha helps guide us through these next months of the pandemic, to help us see what hes seeing. Dont get him wrong: This isnt over. But in America, things are going to feel very, very different in 45 days, for reasons he explains. Then comes another question: How do we make sure the global end to this crisis comes soon after? You can listen here.

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How Democrats Hope to Press Their Advantage on the Stimulus - The New York Times

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Your Illinois News Radar House Democrat on Pritzker loophole closures: We’re not hearing that’s going to happen – The Capitol Fax Blog

Posted: at 3:06 am

* Jake Griffin at the Daily Herald has the best story Ive yet seen about the governors corporate loophole closure proposal. Theres just too much good stuff to excerpt, so you should definitely click here and read the whole thing. However, buried deep down is this little nugget

State Rep. Fred Crespo, a Hoffman Estates Democrat, said he doubts the governor can get those changes made by the legislature.

I am always concerned when there are assumptions built into those budgets that might or might not happen, Crespo said. In closing those corporate loopholes, I think he valued that at close to $1 billion. Were not hearing thats going to happen.

Rep. Crespo chairs the House Appropriations-General Services Committee.

Adding From a House Dem involved with the budget-making process

Im not sure who Fred speaks for here. We havent even started going through each loophole yet.

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Your Illinois News Radar House Democrat on Pritzker loophole closures: We're not hearing that's going to happen - The Capitol Fax Blog

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Opinion: The Progressive Democratic Steamroller – The Wall Street Journal

Posted: at 3:06 am

Democrats on Wednesday passed their $1.9 trillion spending and welfare bill that would have been unimaginable even in the Obama years, and the big news is how easily they did it. The party is united behind the most left-wing agenda in decades, while Republicans are divided and in intellectual disarray. This is only the beginning of the progressive steamroller, and its worth understanding why.

One lesson from the Covid non-fight is that there are no Democratic moderates in Congress. The party base has moved so sharply left that even swing-state Members are more liberal than many liberals in the Clinton years. Democrats lost not a single vote in the Senate and only one in the House. The fear of primary challenges from the left, which took out House war horses in 2018 and 2020, has concentrated incumbent minds.

A second lesson is that President Biden is no moderating political force. Democrats in the House and Senate are setting the agenda, and Mr. Biden is along for the ride. Hes the ideal political front-man for this agenda with his talk of unity and anti-Trump persona, but he isnt shaping legislation. He is signing on to whatever chief of staff Ron Klain tells him he needs to support.

For now at least, there also isnt much of an opposition. With a few exceptions, the media are marching in lockstep support of whatever Democrats want. The substance of the Covid bill was barely covered outside of these pages. Opposition to H.R.1, the federal takeover of state election law, is literally reported as a revival of Jim Crow racism.

The business community has also been co-opted, as it often is at the beginning of a Democratic Presidency. Industries are trying to protect their specific iron rice bowls, but one price is their accommodation with the larger progressive agenda. Small business opposes the $15 minimum wage, but bigger businesses dont mind saddling smaller competitors with higher costs. Big Oil doesnt mind selling out independent frackers on climate rules.

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Can Democrats Still Count on the Grass-Roots? – The New York Times

Posted: at 3:06 am

For Democrats who care deeply about progressive causes, Donald Trumps presidency was a frightening experience. It was also a call to action. Progressive campaigns and causes experienced a huge spike in donations over the past four years, and in 2020 candidates up and down the ballot far outpaced fund-raising records from previous cycles.

So what happens now that Mr. Trump is no longer in power? In a political landscape defined by web advertising, social media campaigns and, yes, online fund-raising, many Democratic analysts and strategists are wondering whether theyll be able to stir up the same kind of financial support.

Donald Trump and his policies motivated a lot of giving to progressive organizations, Mark Mellman, a longtime Democratic pollster and strategist, said Thursday in a phone interview. Whether that will be sustained is an open question.

Seeking answers, Mr. Mellman and Chuck Pruitt, another veteran Democratic consultant, last month undertook a private survey of donors to a wide array of left-leaning organizations and Democratic campaigns. This week, they presented the results on a Zoom call with representatives from various organizations and Democratic groups.

They found that these donors were feeling more positive about Democrats in Washington than in years past, and that they remained energized but a significant chunk of them were in fact planning to donate less, now that Trump is out of office.

The study found that climate change and environmental issues were among their top concerns, even among donors who had given to causes unrelated to the environment. Almost all these progressive donors agree that climate change is a pre-eminent issue, Mr. Mellman said. Its obviously one that gets less attention from the press and from politicians but donors see it as a pre-eminent issue.

It also discovered that donors to these left-leaning groups had become more strongly partisan, with almost two-thirds of respondents to Mr. Mellman and Mr. Pruitts survey identifying as Democrats. That number has steadily climbed over the years: Back in 2007, after Democrats won control of the House as many voters lost faith in President George W. Bush, Mr. Mellman and Mr. Pruitt found that only about half of these kinds of donors were Democrats.

Mr. Mellman and Mr. Pruitt have undertaken studies like this at various moments since the 1990s, usually at what Mr. Mellman calls serious inflection points in national politics when the potential for giving and activism may change.

Its worth noting that these studies dont use what is known in the polling industry as a probability-based model, so their results are subject to forms of error that more scientific surveys wouldnt be. Still, their results can be revealing.

After Mr. Trumps defeat, there have been some signs of donor burnout. Close to nine out of 10 respondents said Mr. Trump had been one of the top factors driving them to donate in recent years. And upward of one in five grass-roots donors said they were now likely to cut back on their gifts to candidates and political parties.

The share who said they planned to increase their giving tapered down to nearly zero.

But Mr. Mellman isnt hugely concerned. This years study found one change from four years ago that he said was particularly heartening for his clients: Just as grass-roots donors to liberal causes have grown more partisan, theyve also grown more positive about the Democratic Party and its leadership.

Close to half of all donors expressed a positive view of the Democratic Party, and a wide array of top Democratic officials received broadly favorable ratings from the surveys Democratic respondents. Those include establishment politicians like President Biden and Senator Chuck Schumer, the majority leader, as well as left-wing figures like Representative Alexandria Ocasio-Cortez and Senator Bernie Sanders.

There was a time when people were really dissatisfied with the party, this leader or that leader, Mr. Mellman said. That is not the case. There is admiration for the party, and nearly universal admiration for the whole range of leaders.

He added, Its not the case that any one faction has a hold on these donors.

The study also revealed that anxiety about Mr. Trumps continued influence on Republican politics remained a concern for many left-leaning donors. And that Representative Marjorie Taylor Greene a former QAnon supporter and staunch Trump defender, whom Democrats stripped of her committee posts this year was nearly as well known and as intensely disliked as the former president.

Trump and Trumps policies motivated a lot of gifts and people recognize that hes gone. But there is still intense antipathy toward his supporters, Mr. Mellman said.

With Democrats controlling only a slim majority in both chambers of Congress, he said many donors still saw the opposition party as a threat to legislation on popular issues like climate change and voting rights. There is also a great fear that the Republicans are going to try to stop these proposals from being enacted, he said.

From Opinion

This piece is part of The Week Our Reality Broke, a series reflecting on a year of living with the coronavirus pandemic and how it has affected American society.

Last spring, as a poorly understood virus swept the planet, something remarkable happened: Across the country, all levels of government put in place policies that just a few months earlier would have been seen by most people not to mention most politicians as radical and politically nave.

Nearly 70 percent of states ordered bans on utility shut-offs, and more than half did so for evictions. Mayors authorized car-free streets to make cities safer for pedestrians, and the federal government nearly tripled the average unemployment benefit. Within weeks, states eliminated extortionist medical co-pays for prisoners and scrapped bail. New Jersey passed a bill that released more than 2,200 incarcerated people all at once.

The pandemic has been a long nightmare, but those were progressive pipe dreams turned reality. The arrival of the coronavirus, along with the wide-scale economic shutdowns to slow its spread, pushed American policymakers to admit that a new world wasnt just possible it was necessary.

While the United States ultimately failed to deliver a coordinated response to the pandemic and millions of people are still struggling, there are important lessons here. Over the past several months, Ive interviewed dozens of activists and policy professionals who have recounted stories of politics shifting quickly on issues they have worked on for years. Measures that were once viewed as likely to cause a spike in crime or a collapse of the housing market, or that were considered just too expensive or simply impractical have, in fact, worked out pretty well.

But many of these emergency interventions are set to disappear. The pandemics end now finally appears to be on the horizon, and millions are desperate to return to normal to our schools and offices, our family visits and holiday celebrations. But when it comes to so many issues from climate change to child care a return to normal is aiming far too low.

The pandemic offered glimpses of what is possible. But will all of this become a blip in history, or will it provide impetus for long-term change? The public has a genuine but brief window over the next few months to make America a fairer, more just and more humane place. If people recognize that, seize that and demand that, they could reshape this country for decades.

You can read the full article here.

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Can Democrats Still Count on the Grass-Roots? - The New York Times

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Opinion | Democrats Are Anxious About 2022 and 2024 – The New York Times

Posted: at 3:06 am

The Lake Research survey produced an unexpected result: Latinos were more sympathetic than either white or Black voters to Republican dog whistle messages.

The dog whistle messages tested by Lake Research included:

Taking a second look at illegal immigration from places overrun with drugs and criminal gangs, is just common sense. And so is fully funding the police, so our communities are not threatened by people who refuse to follow our laws.

And

We need to make sure we take care of our own people first, especially the people who politicians have cast aside for too long to cater to whatever special interest groups yell the loudest or riot in the street.

The receptivity of Hispanics to such messages led Haney-Lpez to conclude that those Latinos most likely to vote Republican do so for racial reasons.

What matters most, Haney-Lpez continued, is susceptibility to Republican dog whistle racial frames that trumpet the threat from illegal aliens, rapists, rioters and terrorists.

Julie Wronski, a political scientist at the University of Mississippi, offered a distinct but similar explanation for the increased Hispanic support for Republicans.

What may be changing is how certain ethnic and nationality groups within Hispanics perceive themselves with regards to their racial and ideological identities, she wrote by email:

If Latinos perceive themselves more as white than as a person of color, then they will react to messages about racial injustice and defunding the police as whites do by using their ideological identity rather than racial identity to shape support.

Wronski reports that

there is also a burgeoning line of research on the role of skin tone among non-Whites. Nonwhites who perceive themselves as having lighter skin tone feel closer to whites and tend to be more conservative than their darker-skinned peers.

Wronski made the case that conservative Hispanics who voted Republican in 2020 are not permanently lost to the Democratic Party:

Identifying as a conservative and supporting conservative policy positions are not the same thing. This is especially true for economic issues, such as unemployment benefits and minimum wage. If you know that a group of Latinos tend to be symbolically conservative and economically liberal, then you can make appeals to them on the shared economic liberalism basis and avoid pointing out diverging views on social issues.

Marc Farinella, a former Democratic consultant who helped run many statewide campaigns in the Midwest and is now at the University of Chicagos Harris School of Public Policy, wrote in response to my inquiry that the fraying of Hispanic support is emblematic of a larger problem confronting Democrats:

American politics in recent decades has become increasingly democratized. Historically-marginalized groups have been brought into the political process, and this, of course, improves representation. But democratization has also, for better or for worse, been highly disruptive to our two-party system.

Traditionally, party leaders tend to support centrist polices and candidates; they are, after all, in the business of winning general elections, he continued:

However, the ability of party leaders to set the partys priorities and define its values has been eroded. They must now compete with activist factions that have been empowered by digital technologies that have greatly amplified their messaging.

As a result, Farinella wrote,

Its now less clear to general election voters precisely what are the Democratic Partys values and priorities. Last year, Republicans succeeded in exploiting this ambiguity by insisting that the messaging of certain leftist activist factions was an accurate reflection of the Partys policy positions and, by and large, the policy positions of most Democratic candidates. As far left activists compete with Democratic Party leaders to define party values and messaging, the centrist voters needed to achieve a durable majority will remain wary about Democratic desires for dominance.

On the other hand, according to Farinella, the lunacy currently underway within the Republican Party could prove to be the Democratic Partys ace in the hole:

A party that demands fealty to a single demagogic politician, condones or even embraces loopy conspiracy theories, recklessly undermines crucial democratic norms and institutions, and believes the best way to improve its electoral prospects is by making it more difficult to vote is not a party destined for long-term success. If the Republican Party continues on its current path, center-right voters might decide that their only real options are to vote Democratic or stay home.

Farinella acknowledged that this might just be wishful thinking.

Ryan Enos, a professor of government at Harvard, is concerned that liberal elites may threaten the vulnerable Democratic coalition:

The question for parties is whether members of their coalition are a liability because they repel other voters from the coalition. For Democrats, this may increasingly be the case with college-educated whites. They are increasingly concentrated into large cities, which mitigates their electoral impact, and they dominate certain institutions, such as universities and the media. The views emanating from these cities and institutions are out of step with a large portion of the electorate.

Many of these well-educated urban whites dont seem to appreciate the urgency of the struggles of middle and low-income Americans, Enos continued:

Most of them support, in theory, economically progressive agendas like minimum wage increases and affordable housing, but they dont approach these issues with any urgency even Covid relief and environmental protection take a back seat to a progressive agenda focused on social issues.

Whit Ayres, a Republican pollster, whose firm, North Star Opinion Research, has studied Hispanic partisan allegiance, wrote in an email that Latinos are far more flexible in their voting than African-Americans:

As a general rule, about 50 percent of Hispanics vote fairly consistently for Democrats, 25 percent vote for Republicans and the remaining 25 percent are up for grabs.

In the Latino electorate, Ayres said, many are sensitive to charges of socialism because of their country of origin. Many are sensitive to law-and-order issues. And many are cultural conservatives, as Reagan argued years ago.

As a result, Ayres continued,

When white liberal Democrats start talking about defunding the police, the Green New Deal and promoting policies that can be described as socialistic, they repel a lot of Hispanic voters. In other words, most Hispanics, like most African-Americans, are not ideological liberals.

The current level of concern has been sharply elevated by a series of widely publicized interviews with David Shor, a 29-year-old Democratic data scientist whose analyses have captured the attention of Democratic elites.

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Opinion | Democrats Are Anxious About 2022 and 2024 - The New York Times

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Coronavirus evolution in bats may have resulted in highly efficient human pathogen – Modern Healthcare

Posted: at 3:06 am

Researchers in the UK, the US, and Belgium have found that while the SARS-CoV-2 virus has undergone significant changes in its evolutionary history, those changes likely occurred while the virus was still found mainly in bats, resulting in a "relatively generalist" virus that was capable of infecting humans without the need for an intermediary species.

Ina study published Friday inPLOS Biology, the researchers noted that shifts in virus hosts are usually associated with novel adaptations in the viruses themselves that allow the microbes to better exploit the cells of the new host species. However, SARS-CoV-2 apparently required little to no significant adaptation to humans from the beginning of the COVID-19 pandemic until October 2020.

The researchers assessed the types of natural selection taking place inSarbecovirusesin horseshoe bats and compared them to early SARS-CoV-2 evolution in humans. While they did find some evidence of diversifying positive selection in SARS-CoV-2 in humans, it was moderate, limited to the early phase of the pandemic, and the purifying selection was much weaker in SARS-CoV-2 than in related batSarbecoviruses. In contrast, they found significant positive episodic diversifying selection acting at the base of the bat virus lineage that SARS-CoV-2 emerged from, accompanied by an adaptive depletion in CpG composition presumed to be linked to the action of antiviral mechanisms in these ancestral bat hosts.

Therefore, the researchers said, while it's still possible that an intermediary species facilitated the transmission of SARS-CoV-2 from bats to humans, their data suggested that the progenitor of SARS-CoV-2 was capable of efficient human-to-human transmission as a consequence of its adaptive evolutionary history in bats.

The researchers first analyzed selection acting on the encoded amino acids of SARS-CoV-2 using 133,741 genome sequences from the GISAID database as of Oct. 12, 2020, representing a sample of the variants circulating in humans during the first 11 months of the pandemic. The vast majority of the mutations they observed in these samples occurred at very low frequencies, with 79 percent of mutations observed in 10 or fewer of the 133,741 SARS-CoV-2 genome sequences.

"Our study results show changes have occurred with SARS-CoV-2, but that most of these mutations are of no evolutionary significance and accumulate by 'surfing' along the millions of transmission events, like they do in all viruses," first author and University of Glasgow researcher Oscar MacLean said in a statement. "The slow rate of evolution can be attributed to the highly susceptible nature of the human population to this new pathogen, with limited pressure from population immunity, and lack of containment, leading to exponential growth."

In contrast, however, the researchers' analysis of theSarbecovirusclade from which SARS-CoV-2 emerged showed evidence of positive selection on the clade's deeper branches, coupled with an adaptive shift in CpG composition in this lineage. The shift in CpG suppression at the base of the novel coronavirus clade could be indicative of an immune evasion adaptation by evading known CpG-targeting mammalian immune mechanisms such as ZAP, they said.

Importantly, the researchers noted that since the end of 2020, there are indications of increased selective pressure in some recent lineages of the virus that are associated with faster spread and a higher-than-usual number of nonsynonymous substitutions the UK (B.1.1.7) and South Africa (B.1.351) variants, for example. These lineages appear to have evolved in humans in association with human immunity, due to previous exposure and/or chronic infections of probably immunocompromised individuals, and not because of the slow rate of evolution associated with acute SARS-CoV-2 infections and transmission that had predominated in the pandemic until October 2020, they said.

More urgently, senior author and Glasgow bioinformatics researcher David Robertson noted in the statement, the virus is now making evolutionary moves away from the January 2020 variant that was used in all of the current vaccines.

"The current vaccines will continue to work against the circulating variants but the more time that passes, and the bigger the differential between vaccinated and not-vaccinated numbers of people, the more opportunity there will be for vaccine escape," he said. "The reason for the shifting of gears of SARS-CoV-2 in terms of its increased rate of evolution at the end of 2020, associated with more heavily mutated lineages, is because the immunological profile of the human population has changed. The first race was to develop a vaccine. The race now is to get the global population vaccinated as quickly as possible."

In their study, the authors also sounded a note of caution that because of the high diversity and generalist nature ofSarbecoviruses,a future spillover from bats, potentially coupled with a recombination event with SARS-CoV-2, is possible. Such an event could lead to the emergence of a SARS-CoV-3 virus, which could itself be sufficiently divergent to evade either natural or vaccine-acquired immunity.

"We must therefore dramatically ramp up surveillance forSarbecovirusesat the human-animal interface and monitor carefully for future SARS-CoV emergence in the human population," they concluded.

This story was first published in our sister publication, Genomeweb.

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Coronavirus evolution in bats may have resulted in highly efficient human pathogen - Modern Healthcare

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Can Evolution Be Predicted? Building a Bridge Between Mathematics and Biology – SciTechDaily

Posted: at 3:06 am

Evolution adapts and optimizes organisms to their ecological niche. This could be used to predict how an organism evolves, but how can such predictions be rigorously tested? The Biophysics and Computational Neuroscience group led by professor Gaper Tkaik at the Institute of Science and Technology (IST) Austria has now created a mathematical framework to do exactly that.

Evolutionary adaptation often finds clever solutions to challenges posed by different environments, from how to survive in the dark depths of the oceans to creating intricate organs such as an eye or an ear. But can we mathematically predict these outcomes?

Postdoctoral fellow Wiktor Mynarski. Credit: Kris Brewer

This is the key question that motivates the Tkaik research group. Working at the intersection of biology, physics, and mathematics, they apply theoretical concepts to complex biological systems, or as Tkaik puts it: We simply want to show that it is sometimes possible to predict change in biological systems, even when dealing with such a complex beast as evolution.

In a joint work by the postdoctoral fellow Wiktor Mynarski and PhD student Michal Hledk, assisted by group alumnus Thomas Sokolowski, who is now working at the Frankfurt Institute for Advanced Studies, the scientists spearheaded an essential advance towards their goal. They developed a statistical framework that uses experimental data from complex biological systems to rigorously test and quantify how well such a system is adapted to its environment. An example of such an adaptation is the design of the eyes retina that optimally collects light to form a sharp image, or the wiring diagram of a worms nervous system that ensures all the muscles and sensors are connected efficiently, using the least amount of neural wiring.

PhD student Michal Hledk. Credit: Martin veda

The established model the scientists base their results on represents adaptation as movement on a landscape with mountains and valleys. The features of an organism determine where it is located on this landscape. As evolution progresses and the organism adapts to its ecological niche, it climbs towards the peak of one of the mountains. Better adaptation results in a better performance in the environment for example producing more offspring which in turn is reflected in a higher elevation on this landscape. Therefore, a falcon with its sharp eyesight is located at a higher point than the birds ancestor whose vision was worse in the same environment.

The new framework by Mynarski, Hledk, and colleagues allows them to quantify how well the organisms are adapted to their niche. On a two-dimensional landscape with mountains and valleys, calculating the elevation appears trivial, but real biological systems are much more complex. There are many more factors influencing it, which results in landscapes with many more dimensions. Here, intuition breaks down and the researchers need rigorous statistical tools to quantify adaptation and test its predictions against experimental data. This is what the new framework delivers.

IST Austria provides a fertile ground for interdisciplinary collaborations. Wiktor Mynarski, originally coming from computer science, is interested in applying mathematical concepts to biological systems.

Professor Gaper Tkaik. Credit: Nadine Poncioni/IST Austria

This paper is a synthesis of many of my scientific interests, bringing together different biological systems and conceptual approaches, he describes this most recent study. In his interdisciplinary research, Michal Hledk works with both the Tkaik group and the research group led by Nicholas Barton in the field of evolutionary genetics at IST Austria. Gaper Tkaik himself was inspired to study complex biological systems through the lens of physics by his PhD advisor William Bialek at Princeton University.

There, I learned that the living world is not always messy, complex, and unapproachable by physical theories. In contrast, it can drive completely new developments in applied and fundamental physics, he explains.

Our legacy should be the ability to point a finger at selected biological systems and predict, from first principles, why these systems are as they are, rather than being limited to describing how they work, Tkaik describes his motivation. Prediction should be possible in a controlled environment, such as with the relatively simple E. coli bacteria growing under optimal conditions. Another avenue for prediction are systems that operate under hard physical limits, which strongly constrain evolution. One example are our eyes that need to convey high-resolution images to the brain while using the minimal amount of energy.

Tkaik summarizes, Theoretically deriving even a bit of an organisms complexity would be the ultimate answer to the Why? question that humans have grappled with throughout the ages. Our recent work creates a tool to approach this question, by building a bridge between mathematics and biology.

Reference: Statistical analysis and optimality of neural systems by Wiktor Mynarski, Michal Hledk, Thomas R. Sokolowski and Gaper Tkaik, 15 February 2021, Neuron.DOI: 10.1016/j.neuron.2021.01.020

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The evolution of the corporate VPN: How COVID-19 has redefined VPN security – Security Magazine

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The evolution of the corporate VPN: How COVID-19 has redefined VPN security | 2021-03-16 | Security Magazine This website requires certain cookies to work and uses other cookies to help you have the best experience. By visiting this website, certain cookies have already been set, which you may delete and block. By closing this message or continuing to use our site, you agree to the use of cookies. Visit our updated privacy and cookie policy to learn more. This Website Uses CookiesBy closing this message or continuing to use our site, you agree to our cookie policy. Learn MoreThis website requires certain cookies to work and uses other cookies to help you have the best experience. By visiting this website, certain cookies have already been set, which you may delete and block. By closing this message or continuing to use our site, you agree to the use of cookies. Visit our updated privacy and cookie policy to learn more.

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The evolution of the corporate VPN: How COVID-19 has redefined VPN security - Security Magazine

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The next evolution of the supply chain will be all about visibility RetailWire – RetailWire

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Mar 15, 2021

PVH Corp., the parent of Calvin Klein and Tommy Hilfiger, is more highly prioritizing real-time inventory visibility to better adjust to potential disruptions coming out of the pandemic.

Eileen Mahoney, PVHs CIO, told The Wall Street Journal, Its allowed the business to get a better handle on where demand is, where the consumer is shopping, and were now going to be nimble about where inventory is.

A new report from the Capgemini Research Institute finds 66 percent of consumer products and retail (CP&R) organizations saying their supply chain strategies will change significantly in the next three years, with much of the attention on heightened visibility.

The supply chain realignment is expected to focus around three areas.

Demand sensing

Sixty-eight percent of CP&R organizations surveyed faced difficulties in demand planning due to a lack of accurate and up-to-date information on fluctuating customer demand during the pandemic. Two-thirds plan to segment supply chains according to demand patterns, product value and regional dimensions post pandemic, while 54 percent will use analytics/AI-machine learning for demand forecasting.

Visibility becomes critical

Facing difficulties quickly increasing or decreasing production capacity, 58 percent of retailers and 61 percent of consumer product organizations are planning to increase investments in digitization of supply chains to improve visibility. Forty-seven percent are planning to invest in automation, 42 percent in robotics and 42 percent in artificial intelligence. Sixty-four percent and 63 percent of organizations are also planning to make extensive use of artificial intelligence and machine learning across transportation and pricing optimization respectively.

From globalization to localization

Seventy-two percent of consumer product organizations and 58 percent of retailers are actively investing in regionalizing or localizing their manufacturing base or nearshoring production to prevent future disruption.

The study found respondents faced significant challenges across the supply chain in the wake of the crisis, including difficulties in end-to-end monitoring of the supply chain, cited by 72 percent; delayed shipments/longer lead times, 74 percent; and bottlenecks at ports or at borders, 68 percent.

DISCUSSION QUESTIONS: How important will visibility be in helping reduce supply chain disruptions in the future? Which of the three themes for improving supply chain agility cited in the article is most important?

"Real-time inventory visibility is critical to address and react to supply chain disruptions and also to improve customer engagement. "

"To design and predict individual product demand in real-time resulting in getting the right product, to the right place, at the right time requires new thinking on both sides "

"Visibility has been a key to the supply chain for years now, but the focus on real-time, omnichannel inventory and agility has become paramount in the last 24 months, no doubt"

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