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Daily Archives: March 31, 2021
Genome analysis for reinfection cases in capital – Hindustan Times
Posted: March 31, 2021 at 3:27 am
The decision comes a day after the Centre said it found the presence of a novel variant of Sars-Cov-2 in Delhi in nine samples, while 65 others had the UK variant B.1.1.7.
PUBLISHED ON MAR 26, 2021 04:45 AM IST
Samples of anyone with a past history of Covid-19 who tests positive again, or those who catch the disease after getting two doses of a vaccine, will be mandatorily sent for whole genome sequencing, the Delhi government ordered on Thursday. The decision is aimed at augmenting surveillance to look for any concerning variants.
The decision comes a day after the Centre said it found the presence of a novel variant of Sars-Cov-2 in Delhi in nine samples, while 65 others had the UK variant B.1.1.7. It is yet to be established how the novel variant changes the nature of the virus, but it contains two mutations (E484Q and L452R) that could make it spread more readily or evade the immunity conferred by a past infection or a vaccine. The directorate general of health services (DGHS) directive also said that each district has to send 12 samples (three each of mild, moderate, severe and critical cases) of Covid-19 positive cases per week to the National Centre for Disease Control (NCDC) for whole genome sequencing. This will help us in detecting which strain is causing most of the infections here whether it is the new variant, other variants such as UK, South Africa or Brazil, or something else, said a senior official from Delhis health department.
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Genome analysis for reinfection cases in capital - Hindustan Times
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Precision BioSciences to Participate in the Guggenheim Healthcare Talks 2021 Genomic Medicines & Rare Disease Day – Yahoo Finance
Posted: at 3:27 am
Bloomberg
(Bloomberg) -- From his perch high above Midtown Manhattan, just across from Carnegie Hall, Bill Hwang was quietly building one of the worlds greatest fortunes.Even on Wall Street, few ever noticed him -- until suddenly, everyone did.Hwang and his private investment firm, Archegos Capital Management, are now at the center of one of the biggest margin calls of all time -- a multibillion-dollar fiasco involving secretive market bets that were dangerously leveraged and unwound in a blink.Hwangs most recent ascent can be pieced together from stocks dumped by banks in recent days -- ViacomCBS Inc., Discovery Inc. GSX Techedu Inc., Baidu Inc. -- all of which had soared this year, sometimes confounding traders who couldnt fathom why.One part of Hwangs portfolio, which has been traded in blocks since Friday by Goldman Sachs Group Inc., Morgan Stanley and Wells Fargo & Co., was worth almost $40 billion last week. Bankers reckon that Archegoss net capital -- essentially Hwangs wealth -- had reached north of $10 billion. And as disposals keep emerging, estimates of his firms total positions keep climbing: tens of billions, $50 billion, even more than $100 billion.It evaporated in mere days.Ive never seen anything like this -- how quiet it was, how concentrated, and how fast it disappeared, said Mike Novogratz, a career macro investor and former partner at Goldman Sachs whos been trading since 1994. This has to be one of the single greatest losses of personal wealth in history.Late Monday in New York, Archegos broke days of silence on the episode.This is a challenging time for the family office of Archegos Capital Management, our partners and employees, Karen Kessler, a spokesperson for the firm, said in an emailed statement. All plans are being discussed as Mr. Hwang and the team determine the best path forward.The cascade of trading losses has reverberated from New York to Zurich to Tokyo and beyond, and leaves myriad unanswered questions, including the big one: How could someone take such big risks, facilitated by so many banks, under the noses of regulators the world over?One part of the answer is that Hwang set up as a family office with limited oversight and then employed financial derivatives to amass big stakes in companies without ever having to disclose them. Another part is that global banks embraced him as a lucrative customer, despite a record of insider trading and attempted market manipulation that drove him out of the hedge fund business a decade ago.A disciple of hedge-fund legend Julian Robertson, Sung Kook Bill Hwang shuttered Tiger Asia Management and Tiger Asia Partners after settling an SEC civil lawsuit in 2012 accusing them of insider trading and manipulating Chinese banks stocks. Hwang and the firms paid $44 million, and he agreed to be barred from the investment advisory industry.He soon opened Archegos -- Greek for one who leads the way -- and structured it as a family office.Family offices that exclusively manage one fortune are generally exempt from registering as investment advisers with the U.S. Securities and Exchange Commission. So they dont have to disclose their owners, executives or how much they manage -- rules designed to protect outsiders who invest in a fund. That approach makes sense for small family offices, but if they swell to the size of a hedge fund whale they can still pose risks, this time to outsiders in the broader market.This does raise questions about the regulation of family offices once again, said Tyler Gellasch, a former SEC aide who now runs the Healthy Markets trade group. The question is if its just friends and family why do we care? The answer is that they can have significant market impacts, and the SECs regulatory regime even after Dodd-Frank doesnt clearly reflect that.Valuable CustomerArchegos established trading partnerships with firms including Nomura Holdings Inc., Morgan Stanley, Deutsche Bank AG and Credit Suisse Group AG. For a time after the SEC case, Goldman refused to do business with him on compliance grounds, but relented as rivals profited by meeting his needs.The full picture of his holdings is still emerging, and its not clear what positions derailed, or what hedges he had set up.One reason is that Hwang never filed a 13F report of his holdings, which every investment manager holding more than $100 million in U.S. equities must fill out at the end of each quarter. Thats because he appears to have structured his trades using total return swaps, essentially putting the positions on the banks balance sheets. Swaps also enable investors to add a lot of leverage to a portfolio.Morgan Stanley and Goldman Sachs, for instance, are listed as the largest holders of GSX Techedu, a Chinese online tutoring company thats been repeatedly targeted by short sellers. Banks may own shares for a variety of reasons that include hedging swap exposures from trades with their customers.Unhappy InvestorsGoldman increased its position 54% in January, according to regulatory filings. Overall, banks reported holding at least 68% of GSXs outstanding shares, according to a Bloomberg analysis of filings. Banks held at least 40% of IQIYI Inc, a Chinese video entertainment company, and 29% of ViacomCBS -- all of which Archegos had bet on big.Im sure there are a number of really unhappy investors who have bought those names over the last couple of weeks, and now regret it, Doug Cifu, chief executive officer of electronic-trading firm Virtu Financial Inc., said Monday in an interview on Bloomberg TV. He predicted regulators will examine whether there should be more transparency and disclosure by a family office.Without the need to market his fund to external investors, Hwangs strategies and performance remained secret from the outside world. Even as his fortune swelled, the 50-something kept a low profile. Despite once working for Robertsons Tiger Management, he wasnt well-known on Wall Street or in New York social circles.Hwang is a trustee of the Fuller Theology Seminary, and co-founder of the Grace and Mercy Foundation, whose mission is to serve the poor and oppressed. The foundation had assets approaching $500 million at the end of 2018, according to its latest filing.Its not all about the money, you know, he said in a rare interview with a Fuller Institute executive in 2018, in which he spoke about his calling as an investor and his Christian faith. Its about the long term, and God certainly has a long-term view.His extraordinary run of fortune turned early last week as ViacomCBS Inc. announced a secondary offering of its shares. Its stock price plunged 9% the next day.The value of other securities believed to be in Archegos portfolio based on the positions that were block traded followed.By Thursdays close, the value of the portfolio fell 27% -- more than enough to wipe out the equity of an investor who market participants estimate was six to eight times levered.Its also hurt some of the banks that served Hwang. Nomura and Credit Suisse warned of significant losses in the wake of the selloff and Mitsubishi UFJ Financial Group Inc. has flagged a potential $300 million loss.You have to wonder who else is out there with one of these invisible fortunes, said Novogratz. The psychology of all that leverage with no risk management, its almost nihilism.(Updates with latest bank to detail exposure in penultimate paragraph.)For more articles like this, please visit us at bloomberg.comSubscribe now to stay ahead with the most trusted business news source.2021 Bloomberg L.P.
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Precision BioSciences to Participate in the Guggenheim Healthcare Talks 2021 Genomic Medicines & Rare Disease Day - Yahoo Finance
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PrecisionLife Continues Growth and Expansion With Acquisition of Danish Genomic Analytics Innovator GenoKey – Business Wire
Posted: at 3:27 am
OXFORD, England & AALBORG, Denmark--(BUSINESS WIRE)--PrecisionLife today announces that it has acquired its long-term Danish technology development partner GenoKey ApS, bringing together the leaders in combinatorial analytics and large-scale genomic analysis, and enabling PrecisionLife to continue its expansion as an AI-enabled precision medicine company. Financial details of the paper-based transaction were not disclosed.
PrecisionLifes platform, which includes technology developed with GenoKey, enables the company to gain unique insights into genes associated with disease, as biomarkers and as targets for drug discovery. PrecisionLifes business model maximizes the impact of its platform by partnering with others as well as building a pipeline of proprietary assets in chronic diseases.
In addition to its expertise and IP, PrecisionLife will benefit from GenoKeys strong relationships with the Danish health system and leading academic clinical research centers including Aalborg, Aarhus and Copenhagen. Recently, PrecisionLife joined the pan-European FEMaLe consortium led by researchers from Aarhus University, which is a 5.3M international EU Horizon 2020 project that aims to develop precision medicine approaches to improve the diagnosis, treatment and quality of life of patients with endometriosis.
PrecisionLife will maintain its core platform development operations at GenoKeys site in Denmark with further team expansion in the region planned. GenoKeys Chairman and co-founder, Hans-Christian Brahe Mller joins the board of the wholly-owned subsidiary, PrecisionLife ApS. GenoKeys scientific advisors will become part of the PrecisionLife advisory group.
The acquisition of GenoKey solidifies a long-term highly productive collaboration around core IP, and positions PrecisionLife for its next round of investment and growth as a leader in the delivery of precision medicine beyond cancer and rare disease said Dr Steve Gardner, CEO of PrecisionLife.
The accuracy and additional insights generated by PrecisionLifes combinatorial analytics platform have been validated in multiple chronic disease areas such as ALS, schizophrenia, asthma, type-II diabetes and endometriosis as well as severe COVID-19. During the pandemic, PrecisionLife was able to find significantly more signals in severe COVID-19 patient datasets than traditional Genome Wide Association Study (GWAS) methods used by international consortia with access to much larger data sets, uncovering unique avenues for therapeutic intervention (1). These achievements are complimented by GenoKeys collaboration with Professor Erling Mellerup and his team at Copenhagen University on bipolar and other neuropsychiatric disorders, initially sponsored by the Lundbeck Foundation.
Welcoming the transaction, Hans-Christian Brahe Mller, Chairman of GenoKey said, This acquisition presents an exciting opportunity to ensure that GenoKeys 10 years of pioneering analytics development can contribute to the global challenge of delivering new solutions for patients with unmet medical needs in chronic diseases, which represent a huge economic and social burden to healthcare systems and millions of patients around the world.
1. COVID-19 studies, see https://www.medrxiv.org/content/10.1101/2020.06.17.20134015v2.full.pdf and https://www.medrxiv.org/content/10.1101/2021.02.08.21250899v1.full.pdf
About PrecisionLife
PrecisionLife is headquartered near Oxford, UK and has operations in Aalborg and Copenhagen, Denmark, Warsaw, Poland and Cambridge, MA, USA. The companys unique combinatorial analytic platform generates more insights into the complex biology of chronic diseases, driving the next wave of precision medicine applications and finding new treatment opportunities for patients unmet medical needs. PrecisionLife partners with disease charities, clinical research groups, CROs, best of breed technology providers and pharma, biotech and healthcare companies to improve our knowledge of chronic disease biology. PrecisionLife operates an innovation engine that translates proprietary disease biology insights into new drug discovery programs, more successful and cost-effective clinical trials and more personalized clinical decision support tools.
For more information see https://precisionlife.com/
Follow us on LinkedIn (precisionlife) and Twitter (@precisionlifeAI)
About GenoKey ApS
GenoKey was founded by Dr Gert Lykke Mller (now Chief Analytics Officer of PrecisionLife), Hans-Christian Brahe Mller and two colleagues. GenoKey pioneered the underlying mathematical approach that enables deep combinatorial analysis of genomic and other clinical and epidemiological patient data. Gert was the first to reduce this innovative approach to computational practice, and this has been developed in collaboration with PrecisionLife into a powerful analytical platform that enables the largest and most detailed precision medicine studies.
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Hong Kong Baptist University-led research unlocks the genomic secrets of organisms that thrive in extreme deep-sea environments – Taiwan News
Posted: at 3:27 am
HONG KONG SAR - Media OutReach - 29 March 2021 - A study led by scientists at Hong Kong Baptist University (HKBU) has decoded the genomes of the deep-sea clam (Archivesica marissinica) and the chemoautotrophic bacteria (Candidatus Vesicomyosocius marissinica) that live in its gill epithelium cells. Through analysis of their genomic structures and profiling of their gene expression patterns, the research team revealed that symbiosis between the two partners enables the clams to thrive in extreme deep-sea environments.
The research findings have been published in the academic journal Molecular Biology and Evolution.
Due to the general lack of photosynthesis-derived organic matter, the deep-sea was once considered a vast "desert" with very little biomass. Yet, clams often form large populations in the high-temperature hydrothermal vents and freezing cold seeps in the deep oceans around the globe where sunlight cannot penetrate but toxic molecules, such as hydrogen sulfide, are available below the seabed. The clams are known to have a reduced gut and digestive system, and they rely on endosymbiotic bacteria to generate energy in a process called chemosynthesis. However, when this symbiotic relationship developed, and how the clams and chemoautotrophic bacteria interact, remain largely unclear.
Horizontal gene transfer between bacteria and clams discovered for the first time
A research team led by Professor Qiu Jianwen, Associate Head and Professor of the Department of Biology at HKBU, collected the clam specimens at 1,360 metres below sea level from a cold seep in the South China Sea. The genomes of the clam and its symbiotic bacteria were then sequenced to shed light on the genomic signatures of their successful symbiotic relationship.
The team found that the ancestor of the clam split with its shallow-water relatives 128 million years ago when dinosaurs roamed the earth. The study revealed that 28 genes have been transferred from the ancestral chemoautotrophic bacteria to the clam, the first discovery of horizontal gene transfera process that transmits genetic material between distantly-related organisms from bacteria to a bivalve mollusc.
The following genomic features of the clam were discovered, and combined, they have enabled it to adapt to the extreme deep-sea environment:
(1) Adaptions for chemosynthesis
The clam relies on its symbiotic chemoautotrophic bacteria to produce the biological materials essential for its survival. In their symbiotic relationship, the clam absorbs hydrogen sulfide from the sediment, and oxygen and carbon dioxide from seawater, and it transfers them to the bacteria living in its gill epithelium cells to produce the energy and nutrients in a process called chemosynthesis. The process is illustrated in Figure 1.
The research team also discovered that the clam's genome exhibits gene family expansion in cellular processes such as respiration and diffusion that likely facilitate chemoautotrophy, including gas delivery to support energy and carbon production, the transfer of small molecules and proteins within the symbiont, and the regulation of the endosymbiont population. It helps the host to obtain sufficient nutrients from the symbiotic bacteria.
(2) Shift from phytoplankton-based food
Cellulase is an enzyme that facilitates the decomposition of the cellulose found in phytoplankton, a major primary food source in the marine food chain. It was discovered that the clam's cellulase genes have undergone significant contraction, which is likely an adaptation to the shift from phytoplankton-derived to bacteria-based food.
(3) Adaptation to sulfur metabolic pathways
The genome of the symbiont also holds the secrets of this mutually beneficial relationship. The team discovered that the clam has a reduced genome, as it is only about 40% of the size of its free-living relatives. Nevertheless, the symbiont genome encodes complete and flexible sulfur metabolic pathways, and it retains the ability to synthesise 20 common amino acids and other essential nutrients, highlighting the importance of the symbiont in generating energy and providing nutrients to support the symbiotic relationship.
(4) Improvement in oxygen-binding capacity
Unlike in vertebrates, haemoglobin, a metalloprotein found in the blood and tissues of many organisms, is not commonly used as an oxygen carrier in molluscs. However, the team discovered several kinds of highly expressed haemoglobin genes in the clam, suggesting an improvement in its oxygen-binding capacity, which can enhance the ability of the clam to survive in deep-sea low-oxygen habitats.
Professor Qiu said: "Most of the previous studies on deep-sea symbiosis have focused only on the bacteria. This first coupled clamsymbiont genome assembly will facilitate comparative studies that aim to elucidate the diversity and evolutionary mechanisms of symbiosis, which allows many invertebrates to thrive in 'extreme' deep-sea ecosystems."
The research was jointly conducted by scientists from HKBU and the HKBU Institute for Research and Continuing Education, the Hong Kong Branch of the Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), The Hong Kong University of Science and Technology, City University of Hong Kong, the Japan Agency for Marine-Earth Science and Technology, the Sanya Institute of Deep-Sea Science and Engineering, and the Guangzhou Marine Geological Survey.
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Hong Kong Baptist University-led research unlocks the genomic secrets of organisms that thrive in extreme deep-sea environments - Taiwan News
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44% of Canadians feel their careers would suffer if they revealed mental health issues: report – Coast Mountain News
Posted: at 3:27 am
Nearly half of Canadians feel that their career options would be limited if their employers knew about their mental health issues, a recent report from Morneau Shepell has found.
The report, released Tuesday (March 23), measures mental health of working Canadians throughout the COVID-19 pandemic, as the 11th month of the crisis continued to take its toll.
It found that 44 per cent of Canadians surveyed believed their careers would suffer if their bosses knew about their mental health. These employees were also found to have the lowest mental health of all groups surveyed, as well as being the least productive at work.
But the bosses may be struggling too, the report found. Half of managers believed their careers would be at risk if they revealed their mental health struggles and 42 per cent said they would feel more negatively about themselves if they had mental health issues. Half of managers also said they drank more in February, when the third wave was on its way, than they did in October, before the second wave.
Overall alcohol use increased among younger and older working Canadians alike during the pandemic, but at different times.
People under the age of 40 were twice as likely to report an uptick in their drinking during the first wave of the pandemic compared to the second wave. Parents were twice as likely as childfree people to drink more during the second and third waves of the pandemic.
Overall mental health has gone up and down for many Canadians throughout the pandemic. Canadians saw a big drop in their mental health in April of last year, as the full force of COVID-19 hit. It then increased somewhat until July and fluctuated throughout the summer before dropping to its lowest point in December. Since the new year, it has lifted slightly.
Looking ahead to the rest of 2021, 23 per cent of employees think that their employer will struggle and one per cent believe they will go out of business.
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Pakistani government accused of ‘sabotaging’ rights watchdog – The Guardian
Posted: at 3:25 am
The prime minister of Pakistan, Imran Khan, and his government have been accused of trying to sabotage the countrys independent human rights watchdog to prevent accountability for mounting abuses and oppression.
Legislators, activists and lawyers told the Guardian that Khans government punished and immobilised Pakistans National Commission for Human Rights (NCHR) over reports that it had produced into human rights abuses and torture carried out by the military, which plays a powerful role in running the country.
On Monday, Islamabad high court directed the government to fill the vacant post of the head of the NCHR, after it was accused of deliberately obstructing the appointments of the new commission members and chairperson for nearly two years, leaving the watchdog in a state of limbo and unable to carry out its duties in holding the government to account.
Mustafa Nawaz Khokar, chairman of the senate committee on human rights, said: Ever since Imran Khans government came to power, the NCHR has been dysfunctional. We raised this issue two or three times times, and after that the senate commission on human rights came to the conclusion that the government is consciously trying to sabotage the commission.
The period of almost two years during which the NCHR has not functioned has coincided with a decline in press freedom and human rights in Pakistan, as well as accusations of a rise in enforced disappearances carried out by military-linked agencies.
The NCHR is a relatively new body in Pakistan. Its remit includes conducting independent investigations into human rights abuses, advising the government on human rights issues and legislation, reviewing the governments implementation of human rights laws, and promoting the issue on the national political agenda.
Although it was established in 2012, it took three years for the commission to begin working properly. The first term of the commission came to an end in May 2019 and it was the responsibility of the governments ministry of human rights to oversee the appointment of its new members, who are supposed to be non-political appointees.
However, almost two years later, no one has been appointed to the watchdog. Khokar said the gloomy human rights record of Khans government was the reason the NCHR had been immobilised.
Imran Khan has been brought into power by the [military] establishment and it does not want to be challenged or held accountable, said Khokar. If such an independent organisation is allowed to function properly, then the true image of this government would be revealed internationally They do not want the human rights violations to be highlighted.
An advert for positions on the committee was first placed in May 2019, but then withdrawn without explanation. Another advert was issued in July 2019, but unlike before, a condition was included that no member of the commission should be more than 65 years old, which was then challenged as illegal.
Akhtar Cheema, a lawyer and former legal adviser to Pakistans senate, said the age-limit restriction was a method of delaying the appointments to the NCHR. The government knew it would be challenged in the court of law and delay the process of the selection, as it was against the law,. And thats what happened, said Cheema.
Pakistan is a signatory of several international conventions on human rights, political rights and torture, and Cheema alleged that one of the ways the NCHR had angered the government was by monitoring the violations of those conventions, mainly by the military.
He cited the examples of NCHR reports, which were not liked by the authorities in power, into the systematic violation of minority rights, and allegations by farmers in Okara, Punjab, that their lands were forcibly occupied by the military.
There are many grey areas in Pakistan and the commission had the judicial power to start inquiries, receive private complaints on human rights violations, conduct research and investigate and publish their reports, all of which bothered the government and the establishment, she said.
NCHR tried to report a few cases of human rights violations and hence it was punished.
Pakistans human rights minister, Shireen Mazari, denied that the government was obstructing the watchdog and said it had readvertised the NCHR posts in October 2020. She blamed the delay on the failure of the leader of the opposition, Shahbaz Sharif, to approve their recommendations for the posts, as is required to prevent the NCHR appointments being political.
The prime minister of Pakistan sent a list of preferences to the leader of the opposition in December, but the opposition leader hasnt sent their nominations to us yet, said Mazari. We have reminded them time and again to send their preferences. The laziness is from the side of the opposition, not the government.
However, when the government sent its preferences to the opposition leader, he was in jail. Sharif was arrested on 28 September last year on allegations of money laundering.
The first chairman of the NCHR, Ali Nawaz Chowhan, said the commission published 35 reports in the span of four years, including a detailed report on the existence of torture in Pakistan, which angered Khans government, who denied the abuses existed.
Chowhan said the previous government had also put restrictions on the commissions work, but the worst had come after Khan came to power in 2018.
It was clear that Pakistan is not implementing the torture conventions. Instead of punishing the commission for its work or reporting, the government should work on resolving human rights issues, Chowhan said, adding that it should have taken just one month, not two years, to appoint new members after May 2019.
They want us to lie to represent a positive image of Pakistan, but I believe it is better to uplift the image of Pakistan by ensuring human rights.
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Pakistani government accused of 'sabotaging' rights watchdog - The Guardian
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American held captive by Iran warns against return to 2015 nuclear deal without gaining concessions – Fox News
Posted: at 3:25 am
Xiyue Wang was a captive of the Iranian government for 40 months. He spent some of that time imprisoned with journalists, academics, former government officials and religious minorities. Before his 2019 release, they had a request.
"We need you to tell the world and for the world to better understand the malign behavior and oppression of the regime," Wang told Fox News. "And today, I think I must do that."
Wang has become an active participant in the renewed debate over American Iran policy. Hes writing, tweeting and speaking a warning to the new administration: The United States cannot return to the 2015 nuclear agreement without extracting deeper concessions from Irans government.
A Princeton University graduate student, in August 2016, Wang was preparing to return home from Tehran after about fourmonths of studying Persian language and history. Iranian intelligence called him in for questioning and confiscated his passport and computers. Less than three weeks later, authorities arrested him.
"They told me explicitly that you're here because you're American, because we want a deal to get Iranian prisoners back and to get Iranian assets back from the United States," said Wang. "Obama engagement didn't change Iranian behavior for better, but actually aggravated its malign behavior."
IRAN HAS BUILT NEW BALLISTIC MISSILE LAUNCH POSITIONS, SATELLITE IMAGES SHOW
In May of 2018, the Trump administration withdrew the US from the nuclear deal and restored the considerable economic sanctions that the agreement had lifted. The administration initiated a maximum pressure campaign designed to economically and diplomatically isolate Iran.
The Biden administration has offered to engage with Iran and the other US allies that are still part of the nuclear agreement. The US has offered to return to compliance if the Iranian government does so first.
"Should that happen, we would then seek, as weve said, to build a longer and stronger agreement, but also to engage on some of the other issues where Irans actions and conduct are particularly problematic," said Blinken last week at NATO headquarters in Brussels, citing Irans destabilization of countries in the region and ballistic missile program.
Irans government has demanded the US return to the agreement first.
Congressional Republicans remain as opposed to the deal as they were when the Obama administration initially signed on to the agreement in 2015.
"The Iranian regime is controlled by radicals who hate America, but for some reason, the Biden administration believes Irans corrupt and brutal leaders will negotiate in good faith," said Senator Marco Rubio. "There can be no good faith negotiations with a regime that uses terrorism as a tool against our allies, pledges our destruction, and has absolutely no respect for human rights."
SEN. BILL HAGERTY WARNS BIDEN OF 'INCREASING AGGRESSION' FROM IRAN, SAYS REGIME TESTING US RESOLVE
Wang is advising the Biden administration to take the Obama administrations initial approach: more pressure.
"If the Biden administration really wants to safeguard the Obama legacy, it has to understand pressure is what made the negotiation eventually work," he said. "That the Trump administration, despite its confusing rhetoric, actually adopted the same approach as Obama pressure backed by credible deterrence."
Wang said he is also motivated to shape US policy by the renewed death sentence of one of his fellow inmates, Ahmadreza Djalali, an Iranian-Swedish academic. Earlier this month, United Nations human rights experts released a statement demanding his release, calling his situation "truly horrific," as hes been held in "prolonged solitary confinement for over 100 days with the constant risk of his imminent execution laying over his head."
Wang also said he would like to share his experience with the State Department, though he said no current officials have contacted him.
In response, a State Department spokesperson said:"We have been in touch with several families of current or former detained, abducted or missing U.S. Citizensin Iran. These conversations are ongoing, and we value the unique perspective they bring."
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During his first week at State, Secretary Blinken also met virtually "with almost all the families with loved onescurrentlyheld hostageand wrongfully or unlawfully detainedabroad," according to the spokesperson.
After more than 3 years in captivity, Wang has returned to his wife and young son, and to his dissertation.Originally, his work focused on a comparative study between Iran and Russia from the early 1900s to the 1930s.
"That project, which has to rely on our Iranian archives, is no longer possible, also, because of my extraordinary experience," he said. "I have shifted my interest and research to the more contemporary issue that is Russia and China's interaction with Iran since the 1970s leading up to the present day."
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Ohio Lt. Gov. Jon Husted facing backlash following series of controversial tweets – News 5 Cleveland
Posted: at 3:25 am
COLUMBUS, Ohio Ohio Lt. Gov. Jon Husted is facing backlash on social media after sharing an article about the controversial claim that the COVID-19 virus was created in a lab in Wuhan, China.
Husted shared an article that quotes Robert Redfield, former director of the Centers for Disease Control and Prevention, saying he believes the virus was manipulated in a Wuhan research laboratory to make it more contagious for research purposes and that the virus "escaped" from the lab.
In the interview with CNN's Dr. Sanjay Gupta, Redfield expressed those ideas, but stressed they were strictly his opinion.
In February, a World Health Organization expert said the coronavirus is unlikely to have leaked from a Chinese lab and is more likely to have jumped to humans from an animal.
Husted shared the article on Twitter Friday evening, writing "So it appears it was the Wuhan Virus after all?"
Many people responded to Husted's tweet, condemning him for pushing a "dangerous narrative" and promoting anti-Asian racism at a time where violence and harassment against the Asian and Asian American community are heightened.
Unsubstantiated claims such as the one shared by Husted Friday evening have been the target of many advocating for the Stop Asian Hate movement across the country.
Thousands of Asian Americans and Pacific Islanders have turned to social media to support the movement using the hashtag #StopAsianHate, which became a top trending topic on Twitter hours after the Atlanta spa shootings that left eight people dead, including six Asian women.
Events aimed at stopping the violence and harassment directed at the Asian community have popped up across the state, with the most recent being a Stop Asian Hate rally and march held Sunday afternoon in Downtown Cleveland.
After the surge of backlash, Husted doubled-down on his original statementattempting to add clarity to his meaning but not apologizing for how his tweet was received.
"To be clear, the tweet above referred only to the Chinese GOVERNMENT. A government of oppression that imprisons people of faith, silences dissenters and the media, manipulates its currency and steals our technology," Husted wrote on Saturday. "Would anyone be shocked to learn they also lied about a communicable disease that caused a pandemic?"
Unsatisfied with Husted's explanation, many Twitter users spoke out again, calling his words "irresponsible," "dangerous," and "reckless."
RELATED: Northeast Ohio groups show solidarity for Asian community after violence, harassment
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Letter to the Editor: Students demand answers, action – The Butler Collegian
Posted: at 3:25 am
Angela Davis, arenowned activist and author. Her event at Butler was cancelled without student input. Photo courtesy of Trident Booksellers and Cafe.
ROUA DAAS |GUEST CONTRIBUTOR | rdaas@butler.edu
On March 29, without warning or discussion, Butler University administration canceled an event titled Joint Struggle and Collective Liberation, which featured a conversation with the revolutionary author, abolitionist and anti-racist activist Angela Davis. The administration abruptly and unilaterally canceled the event without the input of and without even notifying the student leaders who spent four months of tireless planning, coordination and collaboration on the event.
The event, which was set to take place on April 1, sought to highlight the advancements against racism and state violence against Black, Indigenous, People of Color, commonly written as BIPOC. It was to be hosted by the Butler Student Government Association, and co-sponsored by the Race, Gender, and Sexuality Studies Department, the Hub for Black Affairs and Community Engagement and the Diversity Center.
The world-renowned political activist, author and philosopher was anticipated to discuss topics such as antiracism, U.S. and international solidarity movements and the impacts of policing on communities of color, which would have been an unparalleled opportunity for Butler students to learn from and speak with a true Civil Rights icon and prominent leader in intersectional social justice movements.
Butler staff and administration gave an array of inconsistent and unfounded justifications for its racist and authoritative cancelation: failure to follow procedure, too high of an honorarium and inappropriate timing. Currently, they are claiming that due to obscure procedural errors, this event must be postponed and will not occur this school year. Although a statement released by the Student Government Association stated that the event will be postponed, Angela Davis team, along with the behind-the-scenes conversations with university officials, indicated that the contract had been terminated and the event was canceled.
Students working on the event have planned countless past events for which these procedures have not been enforced. The decision to arbitrarily enforce these procedures now is an attempt to specifically censor Angela Davis. It is grounded in the schools history of racism and highlights the lack of genuine support for students of color, academic freedom and political engagement at Butler University, a predominantly-white institution.
Days before Butler Universitys shameless censorship of Angela Davis, the Student Government Association was bombarded by pressure from Zionist students who claimed to oppose Davis event because of her support for the Boycott, Divestment, and Sanctions movement a grassroots demand for nonviolent economic pressure against Israels illegal military occupation of Palestine. This is not the first time this school year that these students have attempted to silence free speech and prevent political events on campus. Many will recall failed attempts this past fall to use student senate resolutions to cancel student organization events and place limits on topics that could be discussed.
This is also not the first time that Zionists have attempted to deplatform Angela Davis for her supportive stance on Palestine. Whether it be the Birmingham Civil Rights Institute, Northeastern University or Butler University, institutions which silence the voices of Black radicals such as Davis are complicit in the systems of racism and oppression which hurt BIPOC people within and beyond Butler University.
Simply put, Butler administrators are trying to silence marginalized voices in order to maintain systems of power and privilege. While Butler University claims to be an institution that supports diversity, equity and inclusion, their actions speak otherwise. In the face of opposition, they immediately rescinded support for their students of color and allowed unfounded complaints to derail a major student-organized event to the detriment of the entire Butler community.
Members of Butler Universitys academic community, as well as allied members of the Indianapolis community, released a statement demanding that the Butler Administration formally apologize to Dr. Angela Davis and immediately reinstate and affirm their support of the event.
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Douglas Murray on oppression and the true passport to success – Yahoo News UK
Posted: at 3:25 am
The Telegraph
Smart motorways were designed without enough thought for "human error", a widows report has found, as it highlights how live lane breakdowns have increased more than 200 per cent. A transport expert hired by Claire Mercer, whose husband died on the M1, has concluded that motorways where the hard shoulder has been scrapped and four lanes of traffic are running have "the lowest level of intrinsic safety". The 220-page dossier insists that the continued roll-out of smart motorways "is not justified" because they have the "highest rate of people killed or seriously injured". Sarah Simpson, a transport specialist at the engineering consultancy Royal Haskoning DHV, has spent a year analysing Highways England data to try to establish whether smart motorways are safer than traditional ones. "I am in no doubt the All Lane Running smart motorway has the lowest level of intrinsic safety of any form of motorway," she writes in her report, sent to the Transport Secretary Grant Shapps and Highways England. She accuses the Government-owned company of having failed to fully use a process called "Safe Systems", which attempts to reduce deaths and injuries by factoring in how "people are fallible with physical vulnerabilities, and that human error occurs" because motorists can make "unwise decisions". The author says Highways England only adopted the "Safe Systems" approach in 2015, seven years after the transport select committee said it warranted "proper exploration for adoption". She adds how new technology - such as CCTV cameras and gantries with speed limits - "can give people the impression that they are safe, even when they are not". The report found that "the risk of being in a live lane breakdown increases 216 per cent" where the hard shoulder has been scrapped and emergency refuges are dotted along the roads. Simpson says that it appears Highways England adopted a "value engineering approach used to compromise safety in order to reduce cost savings" when developing smart motorways. Highways England has rejected repeated criticism of smart motorways by "mathematically offsetting risk" by pointing to other elements in their design that enhance safety, the report adds. Mrs Mercer, from Rotherham, South Yorkshire, said: "Smart motorways are death traps. This report vindicates what I and other campaigners have been saying for some time. The report author warned me that she would only write what she found to be true, so it is independent. "How many more people have to suffer the heartbreak of losing a loved one or suffer life-changing injuries before action is taken?" The report, called An Independent Review of All Lane Running Motorways in England, was commissioned by the law firm Irwin Mitchell which is representing Mrs Mercer, 44, whose husband Jason, 44, died in 2019. A total of four coroners investigating deaths on smart motorways - including Mr Mercers - have written reports warning how the removal of the hard shoulder poses a risk to life. Helen Smith, a lawyer at Irwin Mitchell, which is representing Mrs Mercer, said the report "lays bare more shocking details about how a cost-driven, value engineering approach is compromising the publics safety". She added: It follows on from a number of concerns raised by key figures, including a police commissioner and coroners, about the safety of smart motorways. All of this just adds to the growing groundswell of opinion that more needs to be done to improve safety on smart motorways, which operate on some of the countrys major routes. We call on the Department for Transport, Grant Shapps, and Highways England to acknowledge that the development and roll out of ALRs was flawed. They must act in accordance with their legal duties and take action to improve safety, or face formal legal action. Claire, and other families whose lives have been tragically impacted by crashes on smart motorways, are determined to bring about change for the better. "Well continue to support them in their campaign. If there are witnesses to similar accidents on smart motorways, we encourage them to get in touch with us to support the campaign. A Highways England spokesperson said they will respond to the report. Every road death is a tragic loss of life and we are determined to reduce the number of fatal incidents, and injuries, on our roads," she added. The Governments evidence stocktake of the safety of smart motorways analysed a wealth of data and found that in most ways they are as safe as, or safer than, conventional motorways. We are committed to delivering the stocktake actions to further raise the bar on smart motorway safety."
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