Daily Archives: October 31, 2020

Unconfirmed transactions on Bitcoin network at highest level since 2017 – Cointelegraph

Posted: October 31, 2020 at 11:53 am

The Bitcoin network has slowed down amid Bitcoins (BTC) new price highs, causing a large number of unconfirmed transactions.

According to the mempool transaction count on Blockchain.com, the number of unconfirmed Bitcoin transactions surpassed 100,000 on Oct. 27. This is the highest number of unconfirmed Bitcoin transactions recorded since late 2017, when Bitcoin hit $20,000.

The all-time high of unconfirmed transactions in the Bitcoin mempool was recorded in early December 2017, accounting for about 180,000 transactions, according to data from Blockchain.com.

The high number of unconfirmed transactions comes amid Bitcoin hitting new multi-month highs. On Oct. 27, Bitcoin surpassed a $13,745 threshold, almost touching its previous peak of $13,970 recorded on June 26, 2019.

Amid the bullish trend, the Bitcoin network faced some issues in its key indicators recently. On Oct. 25, Bitcoins hash rate a key indicator of the health of the Bitcoin network tumbled from 151.1 EH/s on Oct. 24 to 116.3 EH/s.

As reported, some mining data aggregators link the drop in Bitcoins hash rate with the end of the wet season in Sichuan. Heavy rains in the region result in low hydroelectric prices for miners. However, as rivers and tributaries dry up, miners are moving to Inner Mongolia and Xinjian.

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Unconfirmed transactions on Bitcoin network at highest level since 2017 - Cointelegraph

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Kanye West: Bitcoiners Know the True Liberation of America and Humanity – Bitcoin News

Posted: at 11:53 am

U.S. presidential candidate Kanye West professed his respect for bitcoiners during a podcast interview with Joe Rogan. He says bitcoiners really have a perspective on what the true liberation of America and humanity will be.

Kanye West is one of the worlds best-selling musicians, having sold over 140 million records worldwide. He announced in July that he is running for President of the United States this year. In a podcast interview with Joe Rogan, published on Saturday, West confirmed that he is still in the running.

Theres a possibility that I could [win]. Its actually technically possible for me to win now which would be the best option for America, he told Rogan. West said that he is on the ballot in 12 states and voters in 17 other states can write him in. I could possibly win now, he claimed, emphasizing that he will definitely win in the next presidential election in 2024.

When asked about bitcoin, West described, Jack Dorsey decentralized Twitter two months before it really hit because he was talking to the Bitcoin guys, adding:

And these are guys that really have a perspective on what the true liberation of America and humanity will be.

Specifically these guys a lot of tech guys were able to use the new information highways and create the next frontier of our existence, he continued.

Furthermore, West revealed that some people have suggested for him to run for the governor of California. If its in Gods plan that part of my path is to be the governor then thats fine but my calling is to be the leader of the free world, he affirmed.

Do you want Kanye West to be the U.S. president? Let us know in the comments section below.

Image Credits: Shutterstock, Pixabay, Wiki Commons

Disclaimer: This article is for informational purposes only. It is not a direct offer or solicitation of an offer to buy or sell, or a recommendation or endorsement of any products, services, or companies. Bitcoin.com does not provide investment, tax, legal, or accounting advice. Neither the company nor the author is responsible, directly or indirectly, for any damage or loss caused or alleged to be caused by or in connection with the use of or reliance on any content, goods or services mentioned in this article.

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Kanye West: Bitcoiners Know the True Liberation of America and Humanity - Bitcoin News

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FTX Increases Trump Futures Margins Before the Election, Biden Futures Lead by 64% – Bitcoin News

Posted: at 11:53 am

At the beginning of the year, the trading platform FTX Exchange launched a futures market so people can bet on the U.S. election and created a futures contract token called TRUMP. On Friday, FTX revealed that the exchange is lifting the initial margin requirements to $0.50 for its TRUMP token contracts.

Individuals who dont live in the United States can participate in betting on the U.S. 2020 presidential election by leveraging the trading platform FTX. News.Bitcoin.com reported on FTX launching its TRUMP token futures contracts back in February, as our newsdesk disclosed a number of other betting portals that use digital currencies to bet on the upcoming election.

At the time, gambling sites and FTXs TRUMP futures had shown Donald Trump was expected to win the 2020 election. However, on September 30, our newsdesks latest report had shown Joe Biden was leading across gambling portals by at least 60%.

On Friday, FTX announced some changes to the original TRUMP token futures market and the exchange is also offering a BIDEN futures market as well. FTX said:

[FTX Exchange will] increase [the] initial margin requirement to $0.50, so you need $0.50 to get short 1 TRUMP or $0.36 (the current price of TRUMP) to get long 1 TRUMP.

Looking at both futures markets on FTX shows that traders are expecting Joe Biden to win the U.S. election and percentages are over 60% today. BIDEN futures tokens are swapping at prices between $0.62 to $0.64 (64% chance of winning) at the time of publication. Meanwhile, TRUMP tokens are swapping at prices between $0.34 to $0.38 (38% chance of winning) a unit, which means current support for a Donald Trump win is lagging.

As stated during the original FTX TRUMP futures announcement, [TRUMP] is a futures contract on FTX, [The token] expires to $1 if Donald Trump wins the 2020 U.S. presidential general election, and $0 otherwise. The latest announcement also notes that FTX is increasing the maintenance margin requirement to $0.40 $0.10 until the election as well.

On Friday, October 30, a great number of polls say that Joe Biden is leading the race. However, reports also show that Trump may actually be in the lead in the United States election polls.

A handful of contrarian pollsters believe Trumps support is underrepresented and that election analysts could be headed for another embarrassing miss on election day, Jonathan Easley from The Hill wrote on Friday.

What do you think about FTX Exchange lifting the initial margin requirements to $0.50 for TRUMP contracts? Let us know what you think about this subject in the comments section below.

Image Credits: Shutterstock, Pixabay, Wiki Commons, FTX Exchange TRUMP futures

Disclaimer: This article is for informational purposes only. It is not a direct offer or solicitation of an offer to buy or sell, or a recommendation or endorsement of any products, services, or companies. Bitcoin.com does not provide investment, tax, legal, or accounting advice. Neither the company nor the author is responsible, directly or indirectly, for any damage or loss caused or alleged to be caused by or in connection with the use of or reliance on any content, goods or services mentioned in this article.

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FTX Increases Trump Futures Margins Before the Election, Biden Futures Lead by 64% - Bitcoin News

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The number of Bitcoin whales hit an all-time high during the latest bull run – Cointelegraph

Posted: at 11:53 am

The number of Bitcoin (BTC) whalesreached a new all-time high amid last week's price ascension. On October 20, there were 2,178 Bitcoin addresses that held at least 1,000 BTC. By October 25, this number increased to 2,231. At current prices, 1,000 BTC translates to approximately $13 million.

Based on this data, we can surmise that the whales control at least 2.23 million Bitcoin a significant figure equivalent to 12% of the current supply.

According to data from BitcoinCharts, these whale addresses actually control a much higher 7,902,469 BTC, or 42% of the total supply. Although we know the number of whale addresses, we do not know how many individuals or entities control them. Multiple addresses could be controlled by a single entity, or likewise a single address could be controlled by multiple parties with a multi-signature wallet.

Researchers allege thatapproximately 1.1 billion BTC are/were controlled by Bitcoin's create and original miner, Satoshi Nakamoto. The vast majority of the coins believed to belong to Nakamoto have never been moved.

We can also observe an increase in the hodling pattern the percentage of Bitcoin supply that has not been moved in a while. 62% of the supply has not seen action in at least 1 year and almost one third has not changed addresses in 3 years or more.

ThoughBitcoin saw its highest weekly close since 2018during the past week, most whales and hodlers do not seem to be in a rush to part with their assets.

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US Regulators Assert Broad Jurisdiction Over Offshore Cryptocurrency Trading Platforms – Finance and Banking – Canada – Mondaq News Alerts

Posted: at 11:52 am

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Recent actions filed in early October 2020 by the U.S.Department of Justice (the "DOJ") and the CommodityFutures Trading Commission (the "CFTC") against BitMEX, alarge cryptocurrency derivatives exchange incorporated in theSeychelles, highlight how virtual asset exchange platforms can besubject to the law and potential enforcement action in multiplejurisdictions based on the locations of their customers. Shortlyafter the filing of these actions, the DOJ published itsCryptocurrency Enforcement Framework, which emphasized that the DOJasserted jurisdiction over virtual asset transactions based notonly on the location of customers but also contacts with"financial, data storage, or other computer systems within theUnited States". These broad assertions of jurisdiction by U.S.prosecutors and regulators, and similar assertions of jurisdictionover foreign trading platforms by Canadian regulators, are acaution to virtual asset exchange platforms to carefully considerthe steps taken to limit their contact with jurisdictions in whichthey do not wish to do business.

Since September 2015, the CFTC has taken the position thatBitcoin and other virtual currencies are commodities under theCommodity Exchange Act. Accordingly, it is the CFTC'sposition that entities that offer leveraged retail transactions,futures, options or swaps for commodities are required to registerwith the CFTC as a future commission merchant (a"Merchant") as well as comply with theBank Secrecy Act, which requires Merchants to establish,implement and maintain an adequate anti-money laundering("AML") program. As part of the AML program, a Merchantis required to implement a written "know your client"("KYC") program that includes risk-based procedures forverifying the identity of its clients. At a minimum, a Merchantmust collect the name, date of birth, address and governmentidentification number of each client prior to their opening anaccount on the Merchant's platform.

In light of the position taken by the CFTC in 2015, BitMEXannounced it was withdrawing from the U.S. market and implementedan Internet Protocol ("IP") address check, also known as"geo-blocking", designed to block U.S. residents fromaccessing the BitMEX trading platform. BitMEX did not,however, implement a KYC program for all of its clients.

On October 1, 2020, the DOJ filed criminal charges (the "DOJAction") accusing four executives of BitMEX of evading rulesdesigned to stop money laundering. That same day, the CFTCannounced that it had filed a related civil enforcement action (the "CFTCAction" together with the DOJ Action, the "BitMEXActions") against five entities and three individuals that ownand operate BitMEX, alleging that they had operated an unregisteredtrading platform in violation of multiple CFTC regulations,including failing to implement required anti-money launderingprocedures.

The BitMEX Actions allege that, since BitMEX's launch inNovember 2014, BitMEX has actively pursued and served thousands ofcustomers located in the U.S., even after its announced withdrawalfrom the U.S. market in 2015. In particular, the DOJ alleges thatBitMEX or its representatives:

Notably, the DOJ alleges that BitMEX's geo-blocking of U.S.IP addresses was deficient and failed to prevent U.S. persons fromtrading on the BitMEX platform. In particular, the DOJ allegesBitMEX failed to implement measures to restrict access to itsplatforms by clients using a virtual private network("VPN"), which can beused to mask the location of a computer's IP address andthereby circumvent geo-blocking.

Based on these allegations, the DOJ and the CFTC allege thatBitMEX failed to register with the CFTC as a Merchant as requiredby the Commodities Exchange Act and knowingly operated itsplatform in violation of multiple CFTC regulations and the BankSecrecy Act, including applicable AML and KYCrequirements.

The BitMEX Actions confirm the willingness of U.S. regulators toassert jurisdiction over virtual asset exchange platforms operatingfrom outside the United States but allegedly with customers orother contacts within the U.S.

As well, shortly after the DOJ Action was filed, the DOJpublished its Cryptocurrency Enforcement Framework, a reportsummarizing its cryptocurrency-related enforcement work to date. Inthis report, the DOJ emphasized its position that it has"robust authority" to prosecute virtual asset serviceproviders and other entities that violate U.S. laws even when theyare not located inside the U.S. The Report asserts that"[w]here virtual asset transactions touch financial, datastorage, or other computer systems within the United States, theDepartment generally has jurisdiction to prosecute the actors whodirect or conduct those transactions."

Like U.S. regulators and prosecutors, Canadian regulators alsotake the view that they have jurisdiction over online securitiestrading platforms operated from outside Canada but with Canadianclients. For example, in September 2018, the Ontario SecuritiesCommission (the "OSC") reached a settlement[PDF] with eToro (Europe)Limited ("eToro"), a Cyprus-based company that hadengaged in online trading of securities or derivatives with Ontarioresidents, including contracts for difference based on exposure tounderlying assets which included cryptocurrencies and stocks. eTorowas not a reporting issuer in Ontario, nor was it registered toengage in the business of trading in accordance with Ontariosecurities law. Nonetheless eToro operated approximately 2,500accounts for Ontario residents between 2008 and 2017. The OSCsettled an enforcement action with eToro based on, among otherterms, a CAD$550,000 administrative penalty, disgorgement of nearlyUSD$2 million, and an undertaking to return funds to Ontarioaccountholders.

Online virtual asset exchange platforms that do not intend toaccept U.S. and Canadian residents as clients nonetheless need tobe careful about inadvertent non-compliance with U.S. or Canadiansecurities, derivatives, money transmission or other laws. At aminimum, platforms need to consider adequate measures to preventresidents from these jurisdictions from accessing their services,but as the DOJ's Cryptocurrency Enforcement Framework notes,prosecutors or regulators may assert jurisdiction based onfinancial or technical contacts. Regulators appear to be highlyskeptical of geo-blocking of IP addresses, which suggests that morerobust KYC processes should be considered to exclude residents fromcertain jurisdictions.

The content of this article is intended to provide a generalguide to the subject matter. Specialist advice should be soughtabout your specific circumstances.

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US Regulators Assert Broad Jurisdiction Over Offshore Cryptocurrency Trading Platforms - Finance and Banking - Canada - Mondaq News Alerts

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Cryptocurrency in Oil and Gas Market Share Forecast by Application 2020 Analysis and Forecasts to 2026 – Aerospace Journal

Posted: at 11:52 am

It is our aim to provide our readers with report for Cryptocurrency in Oil and Gas Market, which examines the industry during the period 2020 2026. One goal is to present deeper insight into this line of business in this document. The first part of the report focuses on providing the industry definition for the product or service under focus in the Cryptocurrency in Oil and Gas Market report. Next, the document will study the factors responsible for hindering and enhancing growth in the industry. After covering various areas of interest in the industry, the report aims to provide how the Cryptocurrency in Oil and Gas Market will grow during the forecast period.

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TheCryptocurrency in Oil and Gas Marketreport between the years 2020 2026 will highlight the current value of the industry. At the same time, there is also an estimate of how much this line of business will be worth at the end of the forecast period. As it is our goal to maintain high levels of accuracy at all times, we will take a look at the CAGR of the Cryptocurrency in Oil and Gas Market. We make sure that all the information available in this report has excellent levels of readability. One way we achieve this target is by Cryptocurrency in Oil and Gas Market segmentation. Going through the report for 2020 2026 will bring our readers up-to-date regarding this industry.

While examining the information from this document, one thing becomes clear, the elements which contribute to increase in demand for the product or service. At the same time, there will be a focus on what drives the popularity of these types of products or services. This report is for those who want to learn about Cryptocurrency in Oil and Gas Market, along with its forecast for 2020 2026. Information regarding market revenue, competitive partners, and key players will also be available.


As discussed earlier, there is segmentation in theCryptocurrency in Oil and Gas Marketreport, to improve the accuracy and make it easier to collect data. The categories which are the dividing factors in the industry are distribution channels, application, and product or service type. With this level of segmentation, it becomes easier to analyze and understand the Cryptocurrency in Oil and Gas Market. At the same time, there is emphasis on which type of consumers become the customers in this industry. When it comes to distribution channels, the Cryptocurrency in Oil and Gas Market report looks at the different techniques of circulation of the product or service.

Regional Overview

In this part of theCryptocurrency in Oil and Gas Marketreport, we will be taking a look at the geographical areas and the role they play in contributing to the growth of this line of business. The areas of interest in this document are as follows Middle East and Africa, South and North America, Europe, and Asia Pacific. From the Cryptocurrency in Oil and Gas Market report, it becomes clear which region is the largest contributor.

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From thisCryptocurrency in Oil and Gas Marketreport, the reader will also get to learn about the latest developments in the industry. The reason is that these products or services have the potential to disrupt this line of business. If there is information about company acquisitions or mergers, this information will also be available in this portion of the Cryptocurrency in Oil and Gas Market report.

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Global Cryptocurrency and Blockchain Market 2020 Impact of COVID-19, Future Growth Analysis and Challenges – The Think Curiouser

Posted: at 11:52 am

The global Cryptocurrency and Blockchain was valued at USD xx Million in 2020. The Cryptocurrency and Blockchain market research study provides itsusers with the market size on the basis of different segments and regions. In addition, the major contributing market participants in the global Cryptocurrency and Blockchain market along with their product/service offerings, revenue, and gross margin is provided under this research report. The research report provides also provides readers the actual analysis of the last four to five years along with forecast till 2025.

Conditions in many of the regions are still bad but some of the regions have eased down some of their COVID-19 restrictions. In many of the regions, there are some countries that have gained some sort of control in the number of COVID-19 cases and have given slight permissions to start the businesses. But there are still fears in some of the countries such as South Korea and northeast China regarding the second wave of the coronavirus infections. The local governments in the respective regions where the number of COVID-19 cases has decreased have imposed strict protocols for the market players regarding social distancing and hygiene. Amidst this the Cryptocurrency and Blockchain

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The report also offers product overviews and detailed interdiction of theglobal Cryptocurrency and Blockchain market. Furthermore, the report will also provide its users with the analysis of market drivers which are expected to support the growth of the Cryptocurrency and Blockchain market in years to come. The report also illustrates the major restraining factors which lead to adversely impact the growth of the market in the analysis period. The opportunities assessment from the future perspective to take strategic decisions is covered in the report. Technology, regulatory landscape, Porters Five Forces Analysis, PESTEL analysis, SWOT analysis, and other analyses of the market are covered in the research.

Cryptocurrency and Blockchain market players included in the reports are:Intel Corporation, Microsoft Corporation, NVIDIA Corporation, BitFury Group Limited, Alphapoint Corporation, Advanced Micro Devices, Xilinx, BitGo, Ripple, BTL Group Ltd.

By Type the Cryptocurrency and Blockchain market is segmented into:Bitcoin, Ethereum, RippleLitecoin, Dashcoin, Others

By Application the Cryptocurrency and Blockchain market is segmented into:Transaction, Investment, Others

Following are the major regions considered for the analysis of the Cryptocurrency and Blockchain market:North America (United States, Canada)Europe (Germany, France, UK, Italy, Russia, Spain)Asia Pacific (China, Japan, Korea, India, Australia, New Zealand)Middle East & Africa (Middle East, Africa)Latin America (Mexico, Brazil, C. America, Chile, Peru, Colombia)

For more information about this report [emailprotected]:https://www.syndicatemarketresearch.com/market-analysis/cryptocurrency-and-blockchain-market.html

Chapter 1:The World Market Research Report Cryptocurrency and Blockchain Help Understand Crucial Information About The Given Market.Chapter 2:The report provides a detailed study on each actor having a major impact on theglobal market Cryptocurrency and Blockchain, such as company profiles, the latest technological advances of market players and the product profile of the player currently available in the market, as well as the regions in which they operate mainly.Chapter 3:It helps to understand the key product segments and their future on the global market Cryptocurrency and Blockchain. It provides strategic solutions and recommendations in key business sectors based on market estimates.Chapter 4:The report also presents an eight-year forecast survey based on expected market growth.

Salient Features of the Report Study:

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Cryptocurrency and Blockchain MarketReport follows a multidisciplinary approach to extract information about various industries. Our analysts perform thorough primary and secondary research to gather data associated with the market. With modern industrial and digitalization tools, we provide avant-garde business ideas to our clients. We address clients living in across parts of the world with our 24/7 service availability.

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Cryptocurrency Custody Software Market Outlook 2020-In-Depth Insight Of Sales Analysis, Growth Forecast And Upcoming Trends Opportunities By Types And…

Posted: at 11:52 am

Estimations about the rise or fall of theCAGR valuefor specific forecast period are evaluated in this report.Cryptocurrency custody software market is expected to grow at a rate of6.3% in the forecast period 2020 to 2027.Data Bridge Market Research report on global cryptocurrency custody software market analyses the growth of the industries constituting the application areas of the market, formulating this information in a market overview to help you in the provision of different market insights. Moreover, this business report combines all-inclusive industry analysis with precise estimates and forecasts to provide complete research solutions with maximum industry clarity for strategic decision making.

The GlobalCryptocurrency Custody Software Marketreport contains all the company profiles of theMajor players Are BitGo, COINBASE, Key Safe Technological Solutions LTD., Kingdom Trust, WatermelonBlock.io, FMR LLC, Ledger SAS, itBit Trust Company, LLC., Base Zero, Inc., Gemini Trust Company, LLC., Paxos Trust Company, LLC,and brands. Cryptocurrency Custody Software marketing document helps industry in deciding upon various strategies such as production, marketing, sales or promotion for a particular product in the market or the new product to be launched.

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The report provides thecompany profile, product specifications, capacity, production value, and market sharesfor each company for the forecast period. In addition, the scope of this market report can be broadened from market scenarios to comparative pricing between major players, cost and profit of the specified market regions. Cryptocurrency Custody Software report is a trustworthy source of market information for the business which assists with the better decision making and outline better business strategies.

Crucial Cryptocurrency Custody Software Market Segment details-:

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All the data and information included in the Cryptocurrency Custody Software business report is drawn from incredibly reliable sources such as websites, annual reports of the companies, white papers, journals, newspapers, and mergers. This market report assists industry by giving actionable market insights and comprehensive market analysis.SWOT analysis and Porters Five Forces Analysisare two of the most widely used techniques while generating this report. A large scale Cryptocurrency Custody Software market report also provides businesses with the company profile, product specifications, production value, contact information of manufacturer and market shares for company.

Focal Points of the Report:

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Some of the Major Highlights of TOC covers:

Chapter 1: Methodology & Scope

Definition and forecast parameters

Methodology and forecast parameters

Data Sources

Chapter 2: Executive Summary

Business trends

Regional trends

Product trends

End-use trends

Chapter 3: Cryptocurrency Custody Software Industry Insights

Industry segmentation

Industry landscape

Vendor matrix

Technological and innovation landscape

Chapter 4: Cryptocurrency Custody Software Market, By Region

North America

South America



Middle East and Africa

Chapter 5: Company Profile

Business Overview

Financial Data

Product Landscape

Strategic Outlook

SWOT Analysis

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In this study, the years considered to estimate the market size of Cryptocurrency Custody Software Market are as follows:-

History Year: 2014-2018

Base Year: 2019

Estimated Year: 2020

Forecast Year 2020 to 2027

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How dogs tracked their humans across the ancient world – Science Magazine

Posted: at 11:49 am

Libyan rock art that may date back 7000 years depicts a hunter and his dog.

By David GrimmOct. 29, 2020 , 2:00 PM

Sometime toward the end of the last ice age, a gray wolf gingerly approached a human encampment. Those first tentative steps set his species on the path to a dramatic transformation: By at least 15,000 years ago, those wolves had become dogs, and neither they nor their human companions would ever be the same. But just how this relationship evolved over the ensuing millennia has been a mystery. Now, in the most comprehensive comparison yet of ancient dog and human DNA, scientists are starting to fill in some of the blanks, revealing where dogs and humans traveled togetherand where they may have parted ways.

Its a really cool study, says Wolfgang Haak, an archaeogeneticist at the Max Planck Institute for the Science of Human History. Were finally starting to see how the dog story and the human story match up.

Dogs are one of the biggest enigmas of domestication. Despite decades of study, scientists still havent figured out when or where they arose, much less how or why it happened. A 2016 study concluded that dogs may have been domesticated twice, once in Asia and once in Europe or the Near East, but critics said there wasnt enough evidence to be sure. A few years later, researchers reported signs of dogs in the Americas as early as 10,000 years ago, yet those canines appear to have vanished without a genetic trace. Other studies have found evidence of ancient dogs in Siberia and elsewhere, but scientists dont know how they got there or how theyre related.

To fill in some of the blanks, two big names in dog and human genetics teamed up: Greger Larson, an evolutionary biologist at the University of Oxford, and Pontus Skoglund, a paleogenomicist at the Francis Crick Institute. Larsen, Skoglund, and colleagues sifted through more than 2000 sets of ancient dog remains dating back nearly 11,000 years from Europe, Siberia, and the Near East. In the process, they added 27 ancient dog genomes to the five already on record. They then compared those with the genomes of 17 humans living in the same places and times as the dogs.

The dog DNA alone revealed some surprises. As early as 11,000 years ago, there were already five distinct dog lineages; these gave rise to canines in the Near East, northern Europe, Siberia, New Guinea, and the Americas, the team reports today in Science. Because dogs had already diversified so much by that time, domestication had to occur long before then, Skoglund says. That fits with archaeological evidence: The oldest definitive dog remains come from Germany about 15,000 to 16,000 years ago.

Remarkably, pieces of these ancient lineages are still present in todays pooches. Chihuahuas can trace some of their ancestry to early American dogs, for example, whereas Huskies sport genetic signatures of ancient Siberian dogs, the team found. If you see a bunch of different dogs in a dog park, Skoglund says, they may all have different ancestries that trace all the way back 11,000 years (see figure below).

Todays dogs can trace their ancestry to canines that lived up to 11,000 years ago.

When the researchers compared their dog DNA with modern and ancient wolf DNA, they got another surprise. Most domesticated animals pick up genetic material from their wild relativeseven after domesticationbecause the two species often live in close proximity and can still mate (think pigs and wild boars). But dogs show no such gene flow from wolves. Instead, the wolves gained new DNA from the dogsa one-way street.

Larson chalks this up to the intimate relationship between dogs and humans. If your pig or chicken becomes a bit wilder thanks to an infusion of feral DNA, it doesnt matter, because youre going to eat them anyway, he explains. But dogs that go native make bad guards, hunting companions, and friends. If youre a dog and you have a bit of wolf in you, thats terrible, Larson says. People will get rid of the dog.

The wolf-dog analysis also suggests dogs evolved only once, from a now-extinct wolf population. Still, Larson, who led the 2016 study on multiple domestication events, says more data are needed to seal the deal.

Then the scientists brought humans into the mix. They selected human DNA samples from the same places and eras for which they had ancient canine DNA, and traced the genetic history of each. Its like you have an ancient text in two different languages, and youre looking to see how both languages have changed over time, Skoglund says.

In many places, the team found a strong overlap between human and dog genomes. For example, farmers and their pups in Sweden about 5000 years ago both trace their ancestry to the Near East. This suggests early farmers took their dogs with them as agriculture spread throughout the continent. Writ large, as humans moved, they moved with their dogs, Larson says.

But sometimes the stories didnt match up. Farmers in Germany about 7000 years ago also came from the Near East and also lived with dogs. But those animals seem more similar to hunter-gatherer pups, which came from Siberia and Europe.

That suggests many early migrants adopted local dogs that were better adapted to their new environment, Haak says. The benefits were many, adds Peter Savolainen, a geneticist at the Royal Institute of Technology and an expert on dog origins. They were cute. You could use them. You could even eat them.

Savolainen calls the study very thorough, and adds its fantastic that the researchers were able to bring together so many data. But he has long argued that dogs arose in Southeast Asia and says the work is incomplete without samples from that corner of the globe. Without those, you could be missing an important part of the picture.

For now, Larson says his team is analyzing a ton of wolf and dog genomes. He and his colleagues have also begun to look at ancient skull shape and genetic markers that could give clues to what early dogs looked like. Whatever he finds, hes counting on being surprised. We have to expect the unexpected, he says, because thats all ancient DNA ever gives us.

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How dogs tracked their humans across the ancient world - Science Magazine

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Prowess of Bionano Genomics’ Saphyr System in Uncovering Novel Genetic Variations That Cause Cancer and Genetic Disease in Full Display at ASHG 2020 -…

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SAN DIEGO, Oct. 27, 2020 (GLOBE NEWSWIRE) -- Bionano Genomics, Inc. (Nasdaq: BNGO) announced that human genetics researchers using the Saphyr system will present their results at the American Society of Human Genetics (ASHG) Annual Meeting, being held virtually at http://www.ashg.org between October 27-30. The impact of structural variation analysis using the Saphyr system will be demonstrated at ASHG with 18 oral and poster presentations which cover an expanding array of diseases like cancer predisposition, microdeletion syndromes, repeat expansion disorders, neurodegenerative diseases, disorders of sex development and a variety of other genetic diseases. Additionally, these presentations show Saphyrs abilities to elucidate the exact structure of complex genomic rearrangements such as large inversions, chromothripsis and low copy repeats.

The scientific importance and quality of the studies utilizing Saphyr and presented at ASHG have increased year over year, said Erik Holmlin, Ph.D., CEO of Bionano. As more scientists present and publish their important discoveries made with Saphyr, an increasing number of potential future Saphyr users become aware of its prowess in uncovering novel genetic variants that contribute to cancer and genetic disease, which could drive more adoption and utilization for basic genetic research and clinical studies alike.

Below is a summary of key presentations to be given at ASHG 2020 featuring the use of Bionanos optical genome mapping technology:

Live Presentation October 29, 2020, 11:45AM-12:00PMDeciphering Genomic InversionsChristopher M. Grochowski, Baylor College of MedicineGenomic inversions are a class of structural variation (SV) relevant in evolution, speciation, and human disease but challenging to detect and resolve using current genomic assays. While short-read WGS can detect a fraction of copy number neutral inversions, those mediated by repeats or accompanied by CNVs remain challenging. The utilization of multiple technologies and visualization of unbroken DNA through long molecule approaches facilitate detection ofin cisevents and resolution of SVs containing two or more breakpoint junctions.

The following Co-Labs, Poster Sessions and Abstracts are available for on-demand viewing during and after ASHG 2020:

Bionano Laboratory Co-Lab Session: Resolving Complex Haplotypes Implicated in Alzheimers and Other Neurodegenerative Diseases.Mark T. W. Ebbert, Neuroscience Department, Mayo ClinicAlzheimers disease is genetically complex with no meaningful therapies or pre-symptomatic disease diagnostics. Most of the genes implicated in Alzheimers disease do not have a known functional mutation, meaning there are no known molecular mechanisms to help understand disease etiology.

In this co-lab session, Mark T. W. Ebbert of the Mayo Clinic will discuss his teams work toward identifying functional structural mutations that drive disease in order to facilitate a meaningful therapy and pre-symptomatic disease diagnostic. Some of the genes and regions implicated in Alzheimers disease are genomically complex and cannot be resolved with short-read sequencing technologies. These regions include MAPT, CR1, and the histocompatibility complex (including the HLA genes).

3342 Bionano Poster Session: High Throughput Analysis of Disease Repeat Expansions and Contractions by Optical MappingErnest Lam, Sr Manager Bioinformatics, Bionano GenomicsRepeat expansions and contractions are associated with degenerative disorders such as facioscapulohumeral muscular dystrophy (FSHD). Southern Blotting is the gold standard for long repeat analysis but has many limitations. Optical genome mapping allows for efficient analysis of diseases associated with repeat expansion and contraction.

2190 Bionano Poster Session: Rapid Automated large Structural Variation Detection in Mouse Genome by Whole Genome SequencingJill Lai, Sr Applications Scientist, Bionano GenomicsIdentifying SVs for key model organisms such as mouse and rat is essential for genome interpretation and disease studies but has been historically difficult due to limitations inherent to available genome technologies. We updated the Saphyr analysis pipeline such that copy number variant (CNV) and SV analyses could now be applied to mouse and other non-human species, and constructed a control SV database for annotating variants, and identified strain-specific SVs/CNVs as well as variation shared among strains.

Additional presentations/abstracts featuring optical genome mapping:

3208 - Long-read sequencing and optical mapping decipher structural composition ofATXN10repeat in kindred with spinocerebellar ataxia and Parkinsons diseasePresented by Birgitt Schuele, Associate Professor, Department of Pathology, Stanford University School of Medicine

3270 - Uniparental isodisomy, structural and noncoding variants involved in inherited retinal degeneration (IRD) in three pedigreesPresented by Pooja Biswas, Ophthalmology Department, University of California, San Diego

Data CoLab: Whole Genome Map Assembly and Structural Variation Analysis with Hitachi Human Chromosome ExplorerPresented by Hitachi-High-Tech America, Inc.

2123 - High-throughput sequencing and mapping technologies applied to 10 human genomes with chromothripsis-like rearrangementsPresented by Uir Souto Melo, Mundlos Lab, Max Planck Institute for Molecular Genetics, Berlin, Germany

2165 -nanotatoR: A tool for enhanced annotation of genomic structural variantsPresented by Emmanuele Delot, Center for Genetic Medicine Research, Childrens National Hospital, Washington, DC

2998 - Highly variable structure and organization of the human 3q29 subtelomeric segmental duplicationsPresented by Umamaheswaran Gurusamy, Cardiovascular Research Institute, University of California San Francisco

2304 - Enlightening the dark matter of the genome: Whole genome imaging identifies a germline retrotransposon insertion inSMARCB1in two siblings with atypical teratoid rhabdoid tumorPresented by Mariangela Sabatella, Princess Mxima Center for Pediatric Oncology, Utrecht, Netherlands

2318 - FaNDOM: Fast Nested Distance-based seeding of Optical MapsPresented by Siavash Raeisi Dehkordi, Computer Science & Engineering, University of California San Diego, La Jolla

3023 - Structural hypervariability of low copy repeats on chromosome 22 is human specificPresented by Lisanne Vervoort, Department of Human Genetics, KU Leuven, Leuven, Belgium

3024 - Telomere-to-telomere assembly and complete comparative sequence analysis of the human chromosome 8 centromereReviewer's Choice Award RecipientPresented by Glennis Logsdon, Genome Sciences, University of Washington, Seattle, WA

3311 - Comprehensive structural variant identification with optical genome mapping and short-read sequencing for diagnosis of disorders/differences of sex development (DSD)Reviewer's Choice Award RecipientPresented by Hayk Barseghyan, Center for Genetic Medicine Research, Children's National Hospital, Washington, DC

3318 - De novo mutation and skewed X-inactivation in girl with BCAP31-related syndromePresented by H.J. Kao, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

3560 - Resolving genomic structures inMECP2Duplication Syndrome provides insight into genotype-phenotype correlationsReviewer's Choice Award RecipientPresented by Davut Pehlivan, Molecular and Human Genetics, Baylor College of Medicine, Houston, TX

2157 -methometR: quantification of long-range haplotype specific methylation levels from Optical Genome MapsPresented by Surajit Bhattacharya, Center for Genetic Medicine Research, Childrens Research Institute, Childrens National Hospital, Washington, DC

About Bionano GenomicsBionano is a genome analysis company providing tools and services based on its Saphyr system to scientists and clinicians conducting genetic research and patient testing, and providing diagnostic testing for those with autism spectrum disorder (ASD) and other neurodevelopmental disabilities through its Lineagen business. Bionanos Saphyr system is a platform for ultra-sensitive and ultra-specific structural variation detection that enables researchers and clinicians to accelerate the search for new diagnostics and therapeutic targets and to streamline the study of changes in chromosomes, which is known as cytogenetics. The Saphyr system is comprised of an instrument, chip consumables, reagents and a suite of data analysis tools, and genome analysis services to provide access to data generated by the Saphyr system for researchers who prefer not to adopt the Saphyr system in their labs. Lineagen has been providing genetic testing services to families and their healthcare providers for over nine years and has performed over 65,000 tests for those with neurodevelopmental concerns. For more information, visitwww.bionanogenomics.com or http://www.lineagen.com.

Forward-Looking StatementsThis press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as may, will, expect, plan, anticipate, estimate, intend and similar expressions (as well as other words or expressions referencing future events, conditions or circumstances) convey uncertainty of future events or outcomes and are intended to identify these forward-looking statements. Forward-looking statements include statements regarding our intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things: the timing and content of the presentations identified in this press release; the effectiveness and utility of Bionanos technology in basic genetic research and clinical settings; the contribution of Saphyr to uncovering novel genetic variants that contribute to cancer and genetic disease; the benefits of Bionanos optical mapping technology and its ability to facilitate genomic analysis in future studies; and Bionanos strategic plans. Each of these forward-looking statements involves risks and uncertainties. Actual results or developments may differ materially from those projected or implied in these forward-looking statements. Factors that may cause such a difference include the risks and uncertainties associated with: the impact of the COVID-19 pandemic on our business and the global economy; general market conditions; changes in the competitive landscape and the introduction of competitive products; changes in our strategic and commercial plans; our ability to obtain sufficient financing to fund our strategic plans and commercialization efforts; the ability of medical and research institutions to obtain funding to support adoption or continued use of our technologies; the loss of key members of management and our commercial team; and the risks and uncertainties associated withour business and financial condition in general, including the risks and uncertainties described in our filings with the Securities and Exchange Commission, including, without limitation, our Annual Report on Form 10-K for the year ended December 31, 2019 and in other filings subsequently made by us with the Securities and Exchange Commission. All forward-looking statements contained in this press release speak only as of the date on which they were made and are based on management's assumptions and estimates as of such date. We do not undertake any obligation to publicly update any forward-looking statements, whether as a result of the receipt of new information, the occurrence of future events or otherwise.

CONTACTSCompany Contact:Erik Holmlin, CEOBionano Genomics, Inc.+1 (858) 888-7610eholmlin@bionanogenomics.com

Investor Relations Contact:Ashley R. RobinsonLifeSci Advisors, LLC+1 (617) 430-7577arr@lifesciadvisors.com

Media Contact:Darren Opland, PhDLifeSci Communications+1 (617) 733-7668darren@lifescicomms.com

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Prowess of Bionano Genomics' Saphyr System in Uncovering Novel Genetic Variations That Cause Cancer and Genetic Disease in Full Display at ASHG 2020 -...

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