Monthly Archives: June 2020

The Drug That Could One Day Help People and Dogs Live Longer – Discover Magazine

Posted: June 20, 2020 at 11:15 am

This story appeared in the July/August 2020 issue as "A Dog's Life."Subscribe to Discovermagazine for more stories like this.

Matt Kaeberleins search for the secret to a long life began, in part, with 560 unique strains of bakers yeast.

He noticed that some of the strains with the greatest longevity tended to divide in slow motion. And he found that this slowdown, which takes place in the molecular mechanisms controlling cell division, could be tinkered with artificially by feeding the yeast a drug called rapamycin.

As he began publishing his results in 2006, other researchers were finding that the drug most commonly used to prevent rejection of organ transplants in humans had a similar anti-aging effect in worms and flies. Several years later, a landmark paper in Nature showed that rapamycin could increase the lifespan of middle-aged mice by 9 to 14 percent.

Veterinarian Kate Creevy (with Poet and Bandana) is one of the co-leaders of the Dog Aging Project. To participate, dogs visit the clinic regularly for checkups. (Credit: Texas A&M University College of Veterinary Medicine & Biomedical Sciences)

By then a professor of pathology at the University of Washington medical school,Kaeberlein found these results both tantalizing and frustrating. There would appear to be molecular processes that are shared in the aging process cross lots of different organisms, he says. That means, in theory, a chemical like rapamycin should therefore also prolong the lives of people. But itd be hard to confirm: Humans live such a long time that it would take at least a generation to find out. What he required was a test subject that approximated humans biologically, but with a much shorter lifespan.

An intriguing solution came up in 2011 in a conversation with biologist Daniel Promislow, who would soon become a new colleague and, like Kaeberlein, was a dog owner. Considering that canines have an average life expectancy of about a decade, everyday exposure to a human living environment and natural susceptibility to many of the same frailties as humans from heart disease to cancer Promislow, who was already working toward starting aging studies in dogs, commented that pooches might just be a pathologists best friend. And pathologists could return the favor by helping to extend pets lifespans, a treat for anyonewho has a dog.

Veterinarian Kate Creevy and Rudy during a regular checkup. (Credit: Amber J. Keyser)

Kaeberlein decided to join in. Launching the Dog Aging Project late last year, with $23 million in funding from the National Institute on Aging, he, Promislow and their colleagues got 80,000 responses to their call for canine volunteers.

By then, their ambitions had expanded considerably. For most of his career, Promislow had wondered why larger dogs live shorter lives. It got me interested in thinking about dogs as a model for aging, he says. Looking at the relationship between dog size and lifespan might be a way to find genes associated with diseases of aging and longevity.

To address this question, Promislow plans to observe dogs over their lifetimes. For the next decade, hell collect genetic profiles, owner surveys and data from veterinary checkups.

According to Kate Creevy, a Texas A&M University veterinarian who co-leads the Dog Aging Project with Promislow and Kaeberlein, one of the biggest challenges will be to establish criteria to measure canine aging objectively, because nobody until now has set out to practice canine gerontology. We need something more specific than for me to walk into an exam room and say, Gosh, your dog looks really good, says Creevy.

Creevy and her colleagues are developing metrics that will encompass both physical and mental health, positioning them to investigate the genetics and environments of fast and slow agers, and to see whether similar systemic breakdowns make different breeds of dog susceptible to different diseases.

Daniel Promislow with Frisbee. (Credit: Tammi Kaeberlein)

Kaeberleins contribution to the Dog Aging Project directly complements the longitudinal study headed by Promislow and Creevy. His working hypothesis is that rapamycin targets pathways that contribute to a variety of aging-related diseases, he explains. If rapamycin delays the onset of cancer in golden retrievers and heart disease in Doberman pinschers, he says hell have evidence that there is a molecular biology of aging common to all canines and possibly other mammals.

He has reason to be optimistic. He recently conducted a 10-week study on a couple of dozen middle-aged dogs, testing for side effects of rapamycin. In that brief period, he saw evidence of more youthful heart activity and more affectionate behavior, which might be interpretable as improved cognition.

In an upcoming study, Kaeberlein will give rapamycin or a placebo to 500 middle-aged dogs for three years. Given their maturity, a couple of hundred will probably die in that period. By comparing the lifespan of dogs on the drug with those chowing on placebos, Kaeberlein will be able to determine whether his treatment really works.

He acknowledges the personal disappointments ahead for some participants, but believes the distress will be outweighed by the potential of prolonged life for dogs and humans alike. To a dog person like Kaeberlein, these extra years are a lot more enticing than spending some additional quality time with some long-lived bakers yeast.

See the original post:
The Drug That Could One Day Help People and Dogs Live Longer - Discover Magazine

Posted in Human Longevity | Comments Off on The Drug That Could One Day Help People and Dogs Live Longer – Discover Magazine

The Equal Protection Issues in the DACA Case – Reason

Posted: at 11:14 am

The DACA decision primarily involved principles of administrative law. (I discussed those issues here and here). But the case also involved a challenge brought under the Equal Protection Component of the Fifth Amendment. (Remember, the Fifth Amendment lacks an Equal Protection Clause).

The Plaintiffs alleged that the rescission of DACA violated the Equal Protection component of the Fifth Amendment. Chief Justice Roberts described the claims:

Tracking these factors, respondents allege that animus is evidenced by (1) the disparate impact of the rescission on Latinos from Mexico, who represent 78% of DACA recipients; (2) the unusual history behind the rescission; and (3) pre- and post-election statements by President Trump.

I discussed the issue way back when in a September 2017 WSJ op-ed (this litigation has been floating around for three-plus years):

That brings us to Mr. Schneiderman's most unsettling claim: that Mr. Trump can't revoke DACA because he is racist. "The President has demonstrated a willingness to disparage Mexicans in a misguided attempt to secure support from his constituency," the states' complaint argues, "even when such impulses are impermissible motives for directing governmental policy."

The filing cites a litany of Mr. Trump's offensive commentshis warning about Mexican "rapists"; his disparagement of Univision anchor Jorge Ramos; his reference in a presidential debate to "bad hombres"; his attacks on Judge Gonzalo Curielas well as his pardon of Joe Arpaio, the former sheriff of Maricopa County, Ariz.

Let's start with Part IV of Roberts's opinion, which was joined (behind the veil of a paper bag) by Justices Ginsburg, Breyer, and Chief Justice Kagan. Roberts rejected each of these three arguments.

None of these points, either singly or in concert, establishes a plausible equal protection claim. First, because Latinos make up a large share of the unauthorized alien population, one would expect them to make up an outsized share of recipients of any cross-cutting immigration relief program. Were this fact sufficient to state a claim, virtually any generally applicable immigration policy could be challenged on equal protection grounds.

We saw a similar argument during the travel ban litigation: Any policy that prohibited entry of people from countries with links to terrorism would be predominantly Muslim.

Second, Roberts rejected the relevance of the history leading up to the rescission:

Second, there is nothing irregular about the history leading up to the September 2017 rescission. The lower courts concluded that "DACA received reaffirmation by [DHS] as recently as three months before the rescission," referring to the June 2017 DAPA rescission memo, which stated that DACA would "remain in effect." But this reasoning confuses abstention with reaffirmation. The DAPA memo did not address the merits of the DACA policy or its legality. Thus, when the Attorney General later determined that DACA shared DAPA's legal defects, DHS's decision to reevaluate DACA was not a "strange about-face." It was a natural response to a newly identified problem

Not quite. The newly-identified problem was that Texas threatened to sue. Sessions thought DACA was illegal for years.

Finally, Roberts rejects the relevance of the President's statements about Hispanics. Why? Because the relevant actors are the DHS Secretary and the Attorney General. More importantly, he dismissed the relevance of Trump's statements under the Arlington Heights framework.

But, even as interpreted by respondents, these statementsremote in time and made in unrelated contextsdo not qualify as "contemporary statements" probative of the decision at issue. Arlington Heights. Thus, like respondents' other points, the statements fail to raise a plausible inference that the rescission was motivated by animus.

Alas, this analysis only had four votes. Therefore, we do not have a five-member majority that dismisses Trump's statements, "remote in time and made in unrelated contexts."

Justice Sotomayor could not don this paper bag. She wrote a partial dissent that focused on Trump's statements. It was very similar to her Trump v. Hawaii dissent.

But "nothing in our precedent supports [the] blinkered approach" of disregarding any of the campaign statements as remote in time from later-enacted policies. Trump v. Hawaii, (2018) (SOTOMAYOR, J., dissenting). Nor did any of the statements arise in unrelated contexts. They bear on unlawful migration from Mexicoa keystone of President Trump's campaign and a policy priority of his administrationand, according to respondents, were an animating force behind the rescission of DACA. Taken together, "the words of the President" help to "create the strong perception" that the rescission decision was "contaminated by impermissible discriminatory animus." This perception provides respondents with grounds to litigate their equal protection claims further.

She also found there was possible pretext in DHS's sudden reversal:

The abrupt change in position plausibly suggests that something other than questions about the legality of DACA motivated the rescission decision. Accordingly, it raises the possibility of a "significant mismatch between the decision made and the rationale provided." Department of Commerce v. New York (2019). Only by bypassing context does the plurality conclude otherwise.

Justice Thomas offered only a footnote about the Equal Protection Clause:

I concur in the judgment insofar as the majority rejects respondents' equal protection claim.

I don't read this statement to agree with Roberts's analysis in Part IV. He only concurs in the judgment.

Justice Kavanaugh's dissent included a similar line:

I therefore respectfully dissent from the Court's judgment on plaintiffs' APA claim, and I concur in the judgment insofar as the Court rejects plaintiffs' equal protection claim.

As I read the case, only four Justices supported the Chief's analysis.

In total, eight Justices rejected the Plaintiffs' Equal Protection arguments. Though there was not a majority opinion for a rationale. Therefore, there is no holding with respect toArlington Heights. And no actual Equal Protection precedent was set. The John Roberts express chugs along.

Read the original:
The Equal Protection Issues in the DACA Case - Reason

Posted in Fifth Amendment | Comments Off on The Equal Protection Issues in the DACA Case – Reason

County executive wants cities to drop opposition to revised officer-involved shooting… – Kent Reporter

Posted: at 11:13 am

The cities of Kent, Federal Way and Auburn need to drop their legal opposition to inquests of officer-involved deaths, says King County Executive Dow Constantine.

Now is the time for action and accountability, Constantine said in a Monday news release. We want the governments that have filed litigation to block inquests to step aside so we can move forward and get to the truth.

But the mayors of each city responded Monday that they plan to continue the lawsuit and want Constantine to restore an inquest process that is fair, transparent, just and legally acceptable within his authority.

The purpose of an inquest is to provide accountability and answers, Kent Mayor Dana Ralph said in a statement. If we are going to be transparent with all parties, we need fair, impartial, factual investigations to occur. This isnt something to take lightly or play games with. The county executive has pushed the envelope too far in trying to politicize a tragic situation. If a member of our community dies as a result of an interaction with law enforcement, I dont want politics I want answers. The only way to get those answers is from a fair investigation and process.

Six inquests have been on hold in King County for two years, frustrating families and making it harder for witnesses to recall details, Constantine said. The Kent, Federal Way and Auburn police departments each have a inquest case on hold. One of the two Seattle police cases on hold includes the death of a Kent man.

State law authorizes, and the King County Charter mandates, the investigation of any death involving a member of law enforcement in the course of their duties.

Inquests are fact-finding hearings conducted before a six-member jury. Inquests are designed to provide transparency into law enforcement actions so the public may have all the facts established in a court of law. Inquest jurors answer a series of questions to determine the significant factual issues involved in the case, and it is not their purpose to determine whether any person or agency is civilly or criminally liable. State law requires a jury of no more than six, and no less than four.

It is unfortunate that Executive Constantine has chosen to portray the intent of our cities in this light, Auburn Mayor Nancy Backus said. In truth, we believe that his executive overreach jeopardizes a full and transparent process for the public, cities and families involved and as such, we will fight its implementation.

Federal Way Mayor Jim Ferrell also opposes the changes.

We believe police accountability is more important now than ever, but the inquest process is an imperfect tool for this, and the new rules are unfair, Ferrell said. We believe it is unconstitutional.

The city of Renton also is part of the suit against the new inquest format.

After a spike of such deaths in 2017, residents expressed serious concerns about the inquest process in the county and the seeming lack of transparency and accountability, according to the news release.

Sonia Joseph is among the residents who complained about the process after a inquest jury in December 2017 found a Kent police officer feared for his life when he shot her son Giovonn Joseph-McDade, 20, in June 2017. Joseph-McDade died from multiple gunshot wounds after he reportedly tried to use his vehicle to run over an officer after a short pursuit on the East Hill.

In response to the complaints, Constantine put all inquests on hold in 2018, then convened a community group to examine the process and suggest reforms. Many of those reforms were included in an Executive Order that went into effect in October 2018 but has not yet been used with all inquests still on hold because of the lawsuits.

Executive Order includes the following major changes:

Old system: District Court judge presided over hearing

New system: A pool of retired judges serves Inquest Administrators to oversee the process.

Old system: King County Prosecuting Attorneys Office facilitated the proceedings, presents evidence.

New system: Prosecuting Attorneys Office will not participate in the hearing, but will continue administrative functions.

Old system: Limited only to facts and circumstances surrounding death.

New system: Expands the interpretation of facts and circumstances to include questions about department policy and training.

Old system: Jurors were often asked whether the officer feared for his or her life at the incident.

New system: Jurors may be asked whether officers actions were consistent with department training and policies. Jurors will no longer be asked whether officers feared for their lives.

Old system: County did not provide attorneys for families.

New system: Attorneys are provided by the Department of Public Defense, if wanted.

Old system: Involved officer could voluntarily testify or be subpoenaed to testify (officer maintains Fifth Amendment right against self-incrimination).

New system: Lead investigator of incident will testify, and chief law enforcement officer (or designee) will answer questions about training and policy. Involved officer can voluntarily testify, but not be subpoenaed. However, if the subpoenaed officer does not testify, may not be represented by legal counsel.

Revised June 15 order: Involved officer may voluntarily testify or be subpoenaed to testify (officer maintains Fifth Amendment right against self-incrimination), and officer may be represented by counsel throughout the proceeding regardless of whether they actually testify.

Constantine said the creation and issuance of the 2018 Executive Order was supported by:

Andre Taylor, founder of Not This Time, a community organization focused on reducing fatal police shootings, changing the laws that govern the use of force and rebuilding trust between our communities and the police who are sworn to protect and serve us. His brother Che Taylor was fatally shot by Seattle Police in 2016

Fae Brooks, co-chair of the King County Inquest Process and Review Committee and retired chief of the criminal investigations division of the King County Sheriffs Office

James Schrimpsher, Lodge 27 President of the Washington Fraternal Order of Police

Diane Narasaki, executive director, Asian Counseling and Referral Services

Almost immediately, several cities including the city of Seattle, King County Sheriff, and individual Seattle police officers filed lawsuits challenging various aspects of the inquest process, Constantine said. Three families of the deceased also filed litigation.

The Obet, Lyle and Butts families lawsuits include several items, such as making inquests include potential criminal charges against officers, and giving attorneys the ability to subpoena officers.

The litigation by the cities of Seattle, Kent, Auburn, Federal Way and King County Sheriffs challenge almost every aspect of the inquest system, including: police policies and training should not be part of inquests, disciplinary history of officers should not be allowed, expert testimony should be limited, and inquests should not be presided over by administrators (retired judges). The King County Sheriff contends that the King County Charter exempts it from inquests.

The city of Kent is utilizing the proper legal channels in order to have an impartial court of law settle a significant dispute regarding the interpretation of law, City communications manager Bailey Stober said in a statement. It is clear to us that the county executive is politicizing and attempting to bully South County cities into dropping a suit which highlights significant legal shortcoming of his new inquest process. The process was so out of line that the city of Seattle first filed the lawsuit and was joined by the King County Sheriff, the executives own county law enforcement agency.

On June 9, the Seattle City Attorney Pete Holmes announced his intent to withdraw the city of Seattle from legal challenges to the inquest process.

Seeking to find compromise, Constantine this week issued a revised Executive Order to allow involved officers to be subpoenaed to testify, and to allow the officer to have an attorney present during the inquest.

King County will defer to the courts on whether inquests, after 50 years of case law stating otherwise, should now consider criminal culpability as part of the process.

The inquest process created by my 2018 Executive Order puts new emphasis on law enforcement training and lethal use-of-force policies so that departments can be held accountable for creating better, safer ways of policing, Constantine said.

Today (Monday) I am revising my Executive Order to remove objections that some departments and some families raised, Constantine said. My new order will allow the involved officer or officers to be subpoenaed to testify, and will allow officers to be represented by counsel throughout the proceeding regardless of whether they actually testify, he said.

The changes arent enough for Kent city leaders.

Our county executive has attempted to create a system of police accountability utilizing a statutory structure created in 1854, before police departments even existed in Washington, Stober said in a city statement. The executive has used imagination and a false sense of authority, not granted to him by state law, to try and create oversight authority over city police departments in 38 cities, none of which he has the authority of oversee. We firmly believe in police oversight and accountability, but that should be a conversation with the community here in Kent, not made unilaterally from a politician in downtown Seattle. Kent residents know what is best for Kent. King County is the only county in Washington that systematically uses the inquest process for this purpose. Inquests in other counties are extremely rare if not ever used, and for good reason they are not an effective tool for police oversight.

Stober continued.

It is absurd that the executive complains that cities are delaying the process of inquests, Stober said. Because of his rush to change the rules with minimal input, he has caused significant delays in the resolution of inquests. Because of the lack of thoughtfulness, it took his office almost two years to produce the rules once he decided to convene his community work group.

Residents speak out

Taylor, founder of Not This Time, said the cities need to change their stance.

I worked with very hard with Executive Constantine and other community partners to draft a new inquest process that was vastly superior, and focused appropriate attention on police policies and trainings in a way that was fair to everyone, Taylor said in the statement released by Constantine. The fact that certain cities were cowed by their police departments into filing lawsuits against the inquest shows just how far we have to go in creating a society that values and protects people of color. The political leaders of these cities have heard our protests. Now they need to act.

Katrina Johnson, the cousin of Charleena Lyles who was fatally shot by Seattle Police in June 2017, spoke at the Kent protest march on June 11 and delivered a message to Kent Police Chief Rafael Padilla shortly after he spoke about how he will listen to the protesters and the need for the department to do better.

If Kent Police Department wants to stand in solidarity with families and black lives, I need you guys to drop the lawsuit that you have forbidding the inquest from going forward, Johnson said. If you guys want to stand in solidarity with black lives, I need you guys to apologize to Sonia Joseph for killing Giovann Joseph-McDade, for killing Eugene Nelson and many others lives that you guys have taken.

Six King County victims with inquest hearings on hold

Damarius Butts

Seattle Police Department

Date of Incident: April 20, 2017

Butts, of Kent, died from multiple gunshot wounds after a reported shootout with Seattle Police on April 20 when he fled after allegedly robbing a 7-Eleven store, 627 First Ave., in downtown Seattle.

Isaiah Obet

Auburn Police Department

Date of Incident: June 10, 2017

Police say the officer shot Obet after the 25-year-old man entered a home armed with a knife and later tried to carjack an occupied vehicle.

Charleena Lyles

Seattle Police Department

Date of Incident: June 18, 2017

Lyles, 30, was shot seven times in her Seattle apartment by two Seattle Police officers. Officers fired after they said Lyles threatened them with a knife.

Eugene Nelson

Kent Police Department

Date of Incident: Aug. 9, 2017

Nelson, 20, died from multiple gunshot wounds after he allegedly tried to flee in a vehicle while dragging an officer in the 23600 block of 104th Avenue Southeast.

Robert Lightfeather

Federal Way Police Department

Date of Incident: Oct. 30, 2017

Lightfeather, 33, died of multiple gun shot wounds from a shooting at South 316th Street and Pacific Highway South outside the Elephant Car Wash. Federal Way police responded to a 911 caller who reported seeing a man pointing a gun at two men.

Curtis Elroy Tade

Kirkland Police Department

Date of Incident: Dec. 19, 2017

Federal Way Mirror reporter Olivia Sullivan contributed to this article.

Talk to us

Please share your story tips by emailing editor@kentreporter.com.

To share your opinion for publication, submit a letter through our website https://www.kentreporter.com/submit-letter/. Include your name, address and daytime phone number. (Well only publish your name and hometown.) Please keep letters to 300 words or less.

More:
County executive wants cities to drop opposition to revised officer-involved shooting... - Kent Reporter

Posted in Fifth Amendment | Comments Off on County executive wants cities to drop opposition to revised officer-involved shooting… – Kent Reporter

7 Prominent LGBTQ+ Technologists, Past and Present – Dice Insights

Posted: at 11:13 am

As we celebrate Pride Month, its worth taking some time to think about some of the prominent members of the LGBTQ+ community who have not only made great strides in technology, but also advocated for recognition and equality. From the mid-20th century to today, LGBTQ+ technologists continue to push the industry forward in new and exciting ways. The following is just a small sampling of these technologists:

An English mathematician helped pioneer computer science and artificial intelligence (A.I.)., Turing is perhaps most famous for his work at Bletchley Park, the center of the U.K.s code-breaking efforts during World War II, where he figured out the statistical techniques that allowed the Allies to break Nazi cryptography.

For his wartime efforts, Turing was appointed an officer of the Order of the British Empire. Following the War, he designed an Automatic Computing Engine, basically a computer with electronic memory (a fully functioning example of the ACE wasnt actually something built in his lifetime, however). He also theorized quite a bit about artificial intelligence (one of his core concepts,the Turing test, is still regarded as a benchmark for testing a machines intelligent behavior).

Turing was prosecuted by the British government for his sexual relationship with another man, Arnold Murray. Found guilty, he was chemically castrated and stripped of his security clearance, which prevented him from working for Britains signals-intelligence efforts. A little over two years later, in 1954, he was found dead of cyanide poisoning, and whether it was suicide or an accident has preoccupied historians for decades.

In 1999,Timelisted Turing among the100 Most Important People of the 20thCentury. Five years later, the British government officially pardoned his conviction.

A technology manager for IBM as well as an LGBTQ+ activist, Edith Edie Windsor was lead plaintiff inUnited States v. Windsor(550 U.S. 744), a landmark U.S. Supreme Court case that found that a crucial portion of the Defense of Marriage Act (DOMA) violated the due process clause of the Fifth Amendment. The ruling helped legalize same-sex marriage (along with a later case,Obergefell v. Hodges).

At IBM, Windsor worked on projects related to operating systems and natural-language processing. After leaving IBM in 1975, she started a consulting firm. In 2016, Lesbians Who Tech, an organization for lesbian and queer women in tech,set up the Edie Windsor Coding Scholarship, with 40 people selected for its inaugural year of giving.

As a computer scientist at IBM in the 1960s, Lynn Conway helped make pioneering advances in computer architecture. One of her projects, ACS (Advanced Computing Systems), essentially became the foundation of the modern high-performance microprocessor. However, IBM fired her when it discovered that she was undergoing gender transition.

Undeterred, Conway moved on to Xerox PARC, where she worked on still more innovative projects, including the ability to put multiple circuit designs on one chip. She was also key in advancing chip design and fabrication. After her stint at Xerox, she moved to DARPA, and from there to the University of Michigan, where she became a professor of electrical engineering and computer science.

At the turn of the century, Conway began to work more in transgender activism. In addition coming out to friends and colleagues, she also used her webpage to describeher personal history(followed up, much later, by a memoir published in 2012). In 2014, she also successfully pushed for the prominent Institute of Electrical and Electronics (IEEE) Board of Directors toinclude trans-specific protections in its Code of Ethics.

Jon maddog Hall has been the Board Chair of the Linux Professional Institute (the certification body for free and open-source software professionals) since 2015. In addition, hes executive director of the industry group Linux International, as well as an author with Linux Pro Magazine.

In a 2012 column in Linux Magazine, Hall came out as gay, citing Alan Turing as a hero and an inspiration.In fact, computer science was a haven for homosexuals, trans-sexuals and a lot of other sexuals, mostly because the history of the science called for fairly intelligent, modern-thinking people, he wrote. Many computer companies were the first to enact diversity programs, and the USENIX organization had a special interest group that was made up of LGBT people. He also became an advocate of marriage equality.

In 2012, Leanne Pittsford founded Lesbians Who Tech, which claims its the largest LGBTQ community of technologists in the world (with 40+ city chapters and 60,000 members). Lesbians Who Tech hosts an annual San Francisco Summit attended by as many as 5,000 women and non-binary people, and it provides mentoring and leadership programs as well as the aforementioned Edie Windsor Coding Scholarship Fund.

Pittsford is also the founder of include.io, which connects underrepresented technologists with companies and technical mentors. In 2016, she also organizedthe third annual LGBTQ Tech and Innovation Summit at the White House.

The third Chief Technology Officer of the United States (U.S. CTO) under President Barack Obama, Megan Smith also served as a vice president at Google. As U.S. CTO, she spearheaded a number of initiatives, including the recruitment of tech talent for national service. She also recognized the need to build up the governments capabilities in data science, open data, and digital policy.

Smith is currently the CEO and co-founder of shift7, which works collaboratively on systemic social, environmental and economic problems. She is also a life member of the board of MIT, as well as a member of the Council on Foreign Relations and the National Academy of Engineering.

Widely considered the first chief executive officer of a Fortune 500 company to come out as gay, Apple CEO Tim Cooktold CNNback in 2014 that he went public in order to show gay children that they could be gay and still go on and do some big jobs in life.

Cook, who once said that being gay is Gods greatest gift to me, joined Apple as a senior vice president in 1998, during some of its leanest years. He quickly solidified his reputation as a peerless operations executive, refining the companys supply and manufacturing chains. As Apple rose to new corporate heights on the strength of its iPod, iPhone, and iPad sales, this supply-chain refinement ensured that millions of devices reached users hands.Cook was promoted to chief operating officer, and stepped in to temporarily head the company when CEO Steve Jobs fell sick with cancer.

Following the death of Jobs in 2011, Cook took the CEO reins and restructured the executive team, with a renewed focus on creating a culture of teamwork and collaboration. He oversaw the launch of the Apple Watch and the AirPods, moving Apple in the long-predicted direction of wearables, and began to shift the companys focus from hardware to cloud-based services such as music and gaming.

Membership has its benefits. Sign up for a free Dice profile, add your resume, discover great career insights and set your tech career in motion. Register now

See the rest here:
7 Prominent LGBTQ+ Technologists, Past and Present - Dice Insights

Posted in Fifth Amendment | Comments Off on 7 Prominent LGBTQ+ Technologists, Past and Present – Dice Insights

Letter to the Editor: Remember and Defend the First Amendment – Dana Point Times

Posted: at 11:10 am

CRAIG ALEXANDER, Dana Point

Ms. Lisa Lynchs request to ban political flags and banners (To Whom It May Concern at The Dana Point Harbor) forgets one vital issue: We live in a Democratic Republic.

One of the values we hold dear in this Republic is freedom of speech or expressionthat includes political speech, even if it is divisive and hurts the feelings of some people who view it. Ms. Lynchs bias is quickly revealed by her attack on all things Donald Trump. I wonder if she would find it equally offensive if a flag on a boat said Biden 2020 or Jesus Saves or TGIF or Merry Christmas or any number of other ideas that might be expressed.

When I drive by a car with a Feel the Bern bumper sticker, I ardently do not agree with the persons support of Senator Bernie Sanders and his policy proposals. But I would defend that persons right to display his support of Sanders publicly. I am glad the sheriffs department does not have a politically correct department going around and telling us what we can and cannot display on our yards, boats and cars.

The First Amendment right of freedom of expression does not have a divisive footnote to it. Ms. Lynch should remember that people cherish the right to express their opinions and those who view those opinions need to cherish and defend the right of that expression even if it is not one they share.

As for her neighborhood association banning political flags and signsdepending on the specific facts and circumstancesthat may be illegal (California Civil Code section 4710.)

Continue reading here:
Letter to the Editor: Remember and Defend the First Amendment - Dana Point Times

Posted in First Amendment | Comments Off on Letter to the Editor: Remember and Defend the First Amendment – Dana Point Times

Another look at the First Amendment | Opinion – Franklin News Post

Posted: at 11:10 am

Please enjoy this previously published column from 2004 while I am away from the office.

While the First Amendment to the U.S. Constitution guarantees us all the opportunity to speak in tongues at the Rocky Creek Church of the New Revival and Second Coming if we so choose, it does not give any of us the right to own a goat named Sparky.

Im sorry, thats just the way it is.

A survey by the McCormick Tribune Freedom Museum found that people are all mixed up about the First Amendment, which gives us freedom of speech, freedom of religion, freedom of the press, the right to assemble and the right to petition for redress of grievances.

A telephone survey of 1,000 people found that more respondents knew Bart as a character on The Simpsons (61 percent), Simon as a judge on American Idol (49 percent) and Federal Express as the one to call when it absolutely, positively has to be there overnight (61 percent) than were aware that freedom of the press is included in the First Amendment (11 percent).

And many believe the First Amendment is much more expansive than it really is. Twenty-one percent said it guarantees each of us the right to own and raise pets (like a goat named Sparky), while 17 percent said the First Amendment affords us the right to drive a car.

We all need a civics lesson, but not one of those boring civics lessons where we lose interest and stare out the window at the girls track team and flunk the final and fail to get into a really good college and end up working at a newspaper and writing about goats, but an exciting civics lesson that applies the First Amendment to a real-life situation we can all understand.

Here we go. Lets say your pet goat Sparky sneaks next door and tears the trailer hitch off your cousin Eugenes Pontiac. Theres already bad blood between the two of you due to a property line dispute and Eugene, being the hothead that he is, says, Ill tell you what Im going to run for mayor and when I win Im going to pass me an ordinance outlawing goats.

Ill tell everybody I know not to vote for a goat-hating hothead! you exclaim. (Freedom of speech)

Frankly, though, youre not worried about Eugene becoming mayor since hes about as popular around town as a Danish cartoonist at an Islamic picnic. (Freedom of religion)

Then, Eugenes opponent is spotted in the background of a Kid Rock sex tape and withdraws from the race, his political career and marriage both in shambles.

GOAT-HATING HOTHEAD WINS MAYORS RACE reads the newspaper headline. (Freedom of the press)

Fearing the town will soon fall into anarchy due to Eugenes utter lack of leadership skills and functional illiteracy, you quickly tack these notices to telephone poles across the community: If you would like to help me get Eugene thrown out of office, meet me at the fellowship hall of the Rocky Creek Church of the New Revival and Second Coming on Tuesday at 8 p.m. (Freedom of speech, freedom of assembly, freedom of religion)

That night, you address the crowd.

If yall thats handling the snakes back there will give me your attention for a minute. Now, we all know a goat-hating hothead like Eugene shouldnt be the mayor. Lets circulate this petition that calls for his immediate removal from office due to his ineptness and goat bias. (Freedom of speech, freedom to petition for redress of grievances)

PETITION SUCCESSFUL GOAT-HATING HOTHEAD OUSTED, reads the newspaper headline. (Freedom of press)

So, heres what weve learned today: The First Amendment is good. It has nothing to do with owning and raising pets. And no one should ever elect a goat-hating hothead mayor.

Scott Hollifield is editor of The McDowell News in Marion, NC. Contact him at rhollifield@mcdowellnews.com.

Read more here:
Another look at the First Amendment | Opinion - Franklin News Post

Posted in First Amendment | Comments Off on Another look at the First Amendment | Opinion – Franklin News Post

Death threats protected by First Amendment, attorney says – Alpena News

Posted: at 11:10 am

News File PhotoThe Alpena County Courthouse is seen.

ALPENA A 26th Circuit Court judge will weigh whether death threats should keep a man in jail if theyre considered free speech.

A judge set a $150,000 bond when David Frey said was arrested on a terrorism charge for allegedly threatening to kill someone, among other charges. But the terrorism charge, the most serious of the charges Frey faced, was dismissed by District Court Judge Thomas LaCross, so the bond should be lowered, Frey argued in Circuit Court.

If the alleged threats arent part of the current charges, they are protected speech under the First Amendment, defense attorney Alan Curtis argued.

Its not a crime to say, In the future, I might kill you,' Curtis said.

The bond is too high for the remaining charges, Frey said, and should be lowered to an amount he can pay so he can leave jail while his case proceeds in court.

Frey is accused of breaking car windows and kicking in a door at the home of a man Frey said he thought might be hurting Freys son.

The terrorism charges connected to verbal death threats made against the man and his family could have led to a 20-year prison sentence.

With that alleged offense no longer in play, Frey should be able to pay less to be released from jail, Curtis, a court-appointed attorney, said.

Alpena County Prosecutor Cynthia Muszynski argued the bond amount is reasonable, despite the lesser seriousness of the remaining charges, because Frey continued making threats via the phone in the county jail after he was arrested.

Curtis also made the First Amendment argument before LaCross in District Court, when the terrorism charge was dropped, but LaCross ruled the bond amount should not change.

Circuit Judge Ed Black, who has not seen a transcript of the court hearing in which LaCross decided to drop the terrorism charge, told the parties that, while retaining the $150,000 bond amount does not sound like something I would have done, he doesnt have all the facts LaCross used in his decision.

Frey will appear in court again in July, after Black has been supplied with the same information originally available to LaCross, to argue for a lower bond.

At that time, the court will also address a motion that Black recuse himself from hearing Freys case because Black handled other cases related to Frey while Black was Alpena County prosecutor.

Today's breaking news and more in your inbox

Link:
Death threats protected by First Amendment, attorney says - Alpena News

Posted in First Amendment | Comments Off on Death threats protected by First Amendment, attorney says – Alpena News

Really Pathetic: First Amendment Expert Torches DOJ Efforts to Stop John Bolton Book – Law & Crime

Posted: at 11:10 am

First Amendment attorney Floyd Abrams on Friday savaged as pathetic the Department of Justices (DOJ) attempt to secure a temporary restraining order against the publication of John Boltons embarrassing book about the Trump White House.

What do you make of the governments argument that the Bolton book should be not published even though it has been written and shipped and all sorts of reporters have it [and] excerpts have appeared? guest host Brian Ross asked during a segment of The Dan Abrams Show on SiriusXM. (Floyd Abrams is the father of Law&Crime founder Dan Abrams.)

To which the elder Abrams replied:

I really think its just a nonstarter as a legal argument. Its one thing for the government to make claims that Mr. Bolton has violated his obligationsI dont think thats a strong claim but thats a claimbut to say that, in a situation where the books already out, where its around the world, where Simon & Schuster sent it to lots of people, where the press has it and is reporting on itthe notion of asking a judge to enter into order which cannot be enforced, effectively, cant be enforced because he cant give the relief the government wants in a meaningful sense.

The DOJ argued in a telephonic hearing on Friday that their request for an injunction should apply to Bolton and other third parties, which could include his publisher, book distributors, and possibly even retail stores. That position strained the bounds of legal credulity for various reasons, of course, but one of Attorney General Bill Barrs subordinates made it anyway.

The book is out, so the idea of [telling the judge to] enter an order in effect saying: Well, no more books, is a meaningless effort, Abrams noted. And particularly because what theyre seeking is a prior restraint, an injunction, a bar on publication. Thats the hardest thing to get of all. Its what the First Amendment most clearly protects against.

Abrams is well-positioned to elucidate on the prior restraint standard; he argued the successful landmark case before the Supreme Court which ultimately established it.

In New York Times v. United States, Abrams represented the newspaper against the Nixon administration in a watershed victory for freedom of speech. The case itself had to do with the publication of the Pentagon Papers leaked by Daniel Ellsberg which showed various U.S. presidents had lied to the public about the basis and progress of Americas police action in Vietnam.

Thats what the Pentagon Papers Case was aboutand lots of other casesmaking it clear, Abrams continued, noting the almost impossible barrier the government must meet when it attempts to censor a publication. It might be possible, but the government has to show terrible harm, and it has to be sure that the harm would occur, and theres no other way to deal with it.

Boltons attorney, Charles J. Cooper, naturally cited to the case Abrams won in a 175-page legal document dropped late Thursday night in his case.Any system of prior restraints of expression comes to th[e] Court bearing a heavy presumption against its constitutional validity, Cooper wrote, quoting and citing the courts opinion in New York Times.

Abrams went on to say that the U.S. vs. Bolton situation as a legal matter seems to be a futile and self-defeating effort by the government and one which cannot and I believe will not be granted.

So, why would they make such an obviously pointless request you think? Ross quizzed the nations most famous First Amendment attorney. Whats the strategy?

Again, Abrams had nothing but contempt for that legal effort:

I can only conclude its not strategy, but its the president. That he told them to do everything: Fire whatever atomic bombs youve got of a legal nature. And someone was unwilling to say no, so theyre going in on that to show how strong they are and how much they care [about what the president says], etcetera, etcetera, because, as a legal claim, its really pathetic.

[image via Alex Wong/Getty Images]

Have a tip we should know? [emailprotected]

Read more from the original source:
Really Pathetic: First Amendment Expert Torches DOJ Efforts to Stop John Bolton Book - Law & Crime

Posted in First Amendment | Comments Off on Really Pathetic: First Amendment Expert Torches DOJ Efforts to Stop John Bolton Book – Law & Crime

Revive Therapeutics betting on psychedelics and potential COVID-19 treatment Bucillamine – Proactive Investors USA & Canada

Posted: at 11:10 am

The company is filing an Investigational New Drug application with the FDA for the Phase 3 confirmatory clinical trial of Bucillamine

Revive Therapeutics Ltd (CSE:RVV) (OTCMKTS:RVVTF) has come a long way in just six months under the stewardship ofCEOMichael Frank.That much is apparent from a casual glance at the share price for the year to date.

However, there is an argument to be made that suggests this may just be the start of the journey for this US and Canadian-listed life sciences innovator. For not only does Revive have a (coronavirus) COVID-19possible treatment headedtowards phase III clinical trials, but it also has some unique and interesting intellectual property (IP) that taps into the emerging area of psychedelics.

Also part of the story, but taking a back-seat for now, is its research around the potential uses of cannabidiol (CBD) to treat auto-immune hepatitis, ischemia and reperfusion injury from organ transplantation.

READ:Revive Therapeutics holds pre-CTA meeting with Health Canada for Bucillamine to treat COVID-19 patients

Revivehas a history of repurposing drugs and IP such asBucillamine,a cysteine derivativeanti-inflammatory that has been used for more than 30 years to treatrheumatoid arthritisin Japan and South Korea.

With an impeccable track record for safety, the companys researchers were assessingthe data fromits potential deployment in acute gout flareswhere ithad successfully completed a phase IIUS Food and Drug Administration (FDA)clinical trial.

Thats when more thoughts were given to the use of Bucillamine to treat lung inflammation.

The drug works by helping restore and enhance an antioxidant called glutathione. Revives team soon realized the same anti-inflammatory action that worked in gout and arthritis could possibly be deployed in people suffering lung inflammation as a result of seasonal flu, H1N1, SARS and, crucially, COVID-19.

In April, it applied to the US regulator to carry out a phase II trial in COVID-19and was surprised by the response.

BasedonBucillamines composition, efficacy, safety and history, as well as a previous, successful interaction with the FDA, the drugs watchdog asked Revive to prepare anInvestigational New Drug (IND) submissionfor a phase IIIconfirmatory trialin COVID-19.

Thats a very large milestone and a major study, says Frank.It gives the company a great deal of credibility.

The company is currently incorporating guidance provided by the US regulator intoits INDpackage, which should beready and submittedby the end of the month,Frank adds.

Another development that is exciting investors is the companys move into psychedelics, which appears incredibly well-timed.

Last year the FDA approvedesketamine to treat depression, making it the first-ever psychedelic drug to receive the regulatory green light in the US, with UK authorities giving their approval for the ketamine-like drug a few months later.

MDMA, meanwhile, has been given breakthrough therapy designation by the US regulator for post-traumatic stress disorder (PTSD), as has psilocybin, the psychoactive found in mushrooms, which is being developed as an alternative to traditional antidepressants.

In March, Revive announcedit was acquiring Psilocin Pharma Corp in an all-paper deal worth $2.75 million. Its focus is psilocybin-based treatments forvariousmedical needs, which includes rare and orphan indications.

Reviveis working with the University of Wisconsin on some new delivery technology that could add another dimension to the research and discoveries to date.

We want to build a better product, with more favorable onset and delivery of psilocybin and then move it down the clinical path, says Frank.

And thats crucial, because like many others in this new and flourishing area of drug discovery, the plan is to formally follow the highly regulated route to market.

In doing so the potential reward could be significant. The psychedelics industry itself is big enough to pique the interest of Big Pharma, with investment bank Canaccord Genuity, in a recent market report,estimating the total market size for all indications under investigation to be as much as $100 billion.

However, the smaller, more innovative players such as Revive, are likely toset the pace and make an impact.

Psychedelics have shown promising efficacy across a broad range of both mental and substance abuse disorders, said Canaccord inits report. Together, the targeted indications affect over one-billion people globally.

Frankstated:I think we have only scratched the surfacein a number of areas, and our team looks forward to educating the market more.

Contact the author Uttara Choudhury at[emailprotected]

Follow her onTwitter:@UttaraProactive

Read more:

Revive Therapeutics betting on psychedelics and potential COVID-19 treatment Bucillamine - Proactive Investors USA & Canada

Posted in Psychedelics | Comments Off on Revive Therapeutics betting on psychedelics and potential COVID-19 treatment Bucillamine – Proactive Investors USA & Canada

These Psychedelic Drugs May Be Key to Revolutionizing Weight Loss Treatment – Yahoo Finance

Posted: at 11:10 am

Houston, Texas--(Newsfile Corp. - June 19, 2020) - The global obesity epidemic is only growing in size.

"New federal data show that the obesity rate in the U.S. has hit 42.4%, up from 30.5% in 1999-2000," according to The Wall Street Journal. Worse, according to the World Health Organization (WHO) obesity has tripled in size over the last 50 years.

By 2030, almost half of U.S. adults will be considered obese.

Unfortunately, with obesity comes issues such as heart disease, stroke, type 2 diabetes, and several types of cancer. Even worse, according to Energy Balance and Obesity: What are the Main Drivers? "There is convincing evidence for a role of obesity as a causal factor for many types of cancer including colorectum, endometrium, kidney, oesophagus, postmenopausal breast, gallbladder, pancreas, gastric cardia, liver, ovary, thyroid, meningioma, multiple myeloma, and prostate cancers."

However, a solution may be found in psychedelics such as DMT and psilocybin, both of which activate serotonin receptors, or "nature's own appetite suppressant," as noted by Psychology Today. "This powerful brain chemical curbs cravings and shuts off appetite. It makes you feel satisfied even if your stomach is not full. The result is eating less and losing weight."

Psychedelics, Like DMT Could Help Treat Eating Disorders

The Yield Growth Corp. (CSE: BOSS) (OTCQB: BOSQF) announced that its majority owned subsidiary NeonMind has filed an additional provisional patent application related to using psychedelics as medicine. The most recent patent application, filed on June 17, 2020 covers the administration of DMT to treat compulsive eating disorder and other illnesses.

DMT, or N,N-Dimethyltryptamine, is a derivative and structural analog of tryptamine, known for its hallucinogenic properties. It currently has no approved medical use, though DMT-containing plants are commonly used in indigenous Amazonian shamanic practice, and are sometimes found in the drink ayahuasca. DMT is found naturally in several plants including Mimosa tenuiflora, Diplopterys cabrerana, and Psychotria viridis. It is structurally similar to psilocin and its precursor psilocybin, a chemical found in so-called "magic mushrooms."

"DMT is a very interesting molecule that acts on the same type of serotonin receptors which are known to regulate appetite," says Dr. William Panenka, Chair of the NeonMind Scientific Advisory Board. "As part of our overall patent strategy, we are establishing defensible intellectual property around multiple compounds that act on these receptors and intend to follow this with rigorous clinical trial work to establish efficacy."

Psilocybin May be Key to Treating Obesity

NeonMind also filed a U.S. provisional patent application in the U.S. for the invention relating to therapeutic administration of psilocybin or psilocin, combined with supportive therapeutic treatment for a patient to provide weight loss benefits and treatment for related health issues.

The provisional patent is for a proposed guided psychedelic psilocybin therapy protocol using psychotherapy prior to, during and after the psychoactive effects of the Psilocybin are felt by the patient. The psychedelic assisted psychotherapy is designed to assist in gaining insights from positive psychedelic experiences, to be integrated into everyday life and to help plan, prepare and make sense of psychedelic experiences for a therapeutic result.

In addition, NeonMind has retained contract research organization Translational Life Sciences Inc. to design and plan an initial preclinical study using psilocybin which is anticipated to begin in the fall of 2020. The preclinical study is anticipated to provide data to design phase 2 human clinical trials to test Psilocybin as a weight loss treatment. The phase 2 clinical trials are anticipated to begin in 2021, subject to receiving all required regulatory approvals.

For more information, visit the company's website at https://yieldgrowth.com.

About MarijuanaStox

MarijuanaStox.com is a leading web destination for all cannabis related companies. Investors can also find current marijuana-related quality financial, medical, legal and social news. MarijuanaStox.com is a media agency in North America dedicated to the cannabis industry, helping companies that operate in the space to attract quality investors, working capital and real publicity. Since 2005, we have had public companies in the US and Canada have rely on us to grow and succeed.

Story continues

Legal Disclaimer

Except for the historical information presented herein, matters discussed in this article contain forward-looking statements that are subject to certain risks and uncertainties that could cause actual results to differ materially from any future results, performance or achievements expressed or implied by such statements. Winning Media which has a partnership with http://www.MarijuanaStox.com is not registered with any financial or securities regulatory authority and does not provide nor claims to provide investment advice or recommendations to readers of this release.

For making specific investment decisions, readers should seek their own advice. Winning Media, which has a partnership with http://www.MarijuanaStox.com, is only compensated for its services in the form of cash-based compensation. Pursuant to an agreement between Winning Media (partners of MarijuanaStox.com) and The Yield Growth Corp, Winning Media has been paid three thousand five hundred dollars for advertising and marketing services for The Yield Growth Corp. We own ZERO shares of The Yield Growth Corp. Please click here for full disclaimer.

Contact Information:2818047972ty@marijuanastox.com

To view the source version of this press release, please visit https://www.newsfilecorp.com/release/58207

Link:

These Psychedelic Drugs May Be Key to Revolutionizing Weight Loss Treatment - Yahoo Finance

Posted in Psychedelics | Comments Off on These Psychedelic Drugs May Be Key to Revolutionizing Weight Loss Treatment – Yahoo Finance