Monthly Archives: April 2020

50 Years Ago Today, USSR-Rest Of The World Started – Chess.com

Posted: April 11, 2020 at 7:06 pm

Today, half a century ago, one of the greatest chess events of the 20th century started in Belgrade, Yugoslavia. Virtually all of the top players in the world participated in this match between the Soviet Union and the Rest of the World.

The event was repeated two more times in later years, but never on the same level, and it never again spoke to the imagination quite as much as the first event. The 1970 match USSR vs Rest of the World, "an epoch-making battle" in the words of GM Garry Kasparov,had virtually all the top playersincluding GM Bobby Fischertogether for one week in Belgrade, the capital of what was then Yugoslavia.

Video footage of the event (without sound).

Fischer's participation in this event (or in any event, in fact) was far from automatic. In his "My Great Predecessors IV," Kasparov tells a story about how the American player, who would become world champion two years later, initially hesitated.

According to Bobby, he was persuaded by the chief arbiter Bozidar Kazic: "He flew to America and spent a long time trying to convince me. And suddenly he said: 'Think about itIf you don't play in the Match of the Century, it will simply be the greatest chess absurdity of the century!' It was hard for me to say anything in reply..."

The team match was held between March 29 and April 4, 1970 in the Great Hall of the Dom Sindikata(the House of Trade Unions) in Belgrade, witnessed by 2,000 spectators and 63 foreign correspondents.

Reportedly, the city lights on the square in front of the match hall were dimmed during the event, so that the outside spectators could better follow the games on what must have been one of the earliest versions of an electronic chessboard.

The match consisted of four rounds, with teams of 10 players each (including six world champions, past, present, and future!) playing four games against the same player.

The Soviet Team, in board order: Boris Spassky, Tigran Petrosian, Viktor Korchnoi, Lev Polugaevsky, Efim Geller, Vasily Smyslov, Mark Taimanov, Mikhail Botvinnik, Mikhail Tal, Paul Keres, and reserves Leonid Stein and David Bronstein.

The Rest of the World Team in board order: Bent Larsen, Fischer, Lajos Portisch, Vlastimil Hort, Svetozar Gligoric, Samuel Reshevsky, Wolfgang Uhlmann, Milan Matulovic, Miguel Najdorf, Borislav Ivkov, and reserves Fridrik Olafsson and Klaus Viktor Darga.

Fischer played on board two instead of board oneanother interesting story. For the line-up of the teams, Arpad Elo's rating system (brand new at the time) had been used, butLarsen objected, claiming he deserved top board based on his recent results and Fischer's inactivity.Here's what happened after, also from Kasparov, who quotes Taimanov:

"This was an open challenge to Fischer, and it appeared that a conflict was inevitable," writes Taimanov. "But the unbelievable occurred! When Dr. [Max] Euwethe team captainwent into Bobby's room, the latter was lying on a divan with his head buried in a pillow. And hardly had Euwe begun fulfilling his complicated diplomatic mission, when Bobby, not even turning to his respected colleague, barked out: 'I don't object...'"

Later it was concluded that Fischer, who hadn't played competitive chess for nearly two years, didn't feel fully ready yet to meet Spassky, and perhaps rightly so.He lost to Spassky later in the year at the Siegen Olympiad.

Characteristically, the Soviets prepared seriously for the event. They had taken up a training camp where leading trainers andtheoreticians such as GM Isaac Boleslavsky and GM Semyon Furman were present. As the board order of the World was known to them (apart from the late Fischer/Larsen switch), it was decided to adjust the order of their line-up to increase chances in the individual mini-matches.

The USSR ended up winning the match by the narrowest of margins: 20.5-19.5. It could well have been a tie had Portisch not allowed a threefold repetition in a promising position against Korchnoi on the last day.

Another key game on the last day was the one between Smyslov and Olafsson (who substituted for Reshevsky). In what was the last game that was still going, Smyslov won. He later wrote:

"The final result depended completely on us. To make a draw would mean a draw in the match as a whole. Were I to win, we would win. Were Olafsson to win Imagine the situation?! (...)Thats why I at once told everyone that this victory remains for me one of the most memorable; in terms of its intensity, it can only be compared with the one that made me world champion."

It was a disappointing result for the mighty Soviets, especially when one took into account that they had clearly lost the battle on the top-four boards. Fischer won his mini-match with Petrosian with the highest individual score for the World (3-1), starting with two wins and then playing two draws.

(On the last day, Stein played for Spassky who was ill, while Olafsson played for Reshevsky for religious reasons.)

Naturally, the event produced a lot of excellent games. The most famous is the encounter between Larsen and Spassky from the second day of the match. Starting with 1.b3, the great Dane was wiped off the board in just 17 moves, with Black's h-pawn playing a major role.

Here's the game with annotations by Chess.com's @SamCopeland, who also recorded a video that can be found on his blog.

Here's the first of Fischer's two wins against Petrosian. According to a report by Dragoslav Andric in "Chess Life & Review" (June 1970), the players played on achess table different from the rest.

"Made of white and green marble, it was Fidel Castro's gift (on the occasion of the Olympiad in Havana in 1966) to one of Belgrade's chess functionaries. The chess set, too, had to be specialFischer demanded that it not be too shiny."

Here's the game, with brief annotations from the players taken from the tournament bulletin.

As Larry Evans, Fischer's second at the event, wrote in "Sports Illustrated" (April 20, 1970), among the prizes were two cars:

Among the prizes were two automobilesa Fiat for the winner at the first board and a Russian-built Moskvich at the second. "All I need is another half-point to win the Moskvich," Fischer said. I was acting as Fischer's second, and this comment told me that the days of hard trying were over; he was going to play it safe. And he did. The game was drawn. Since he does not like to drive he said he was going to sell the car. European chess masters told him not to do it and said it was a fine car, except that it could not always be depended upon to run uphill.

The prize for the best game was awarded to Geller for his win against Gligoric on the first day. Here it is with annotations from the tournament bulletin.

Part of this article was based on Douglas Griffin's recentblog post. Griffin (from Insch, Aberdeenshire, Scotland) was an active chess player in the 1980s and has a keen interest in the history and (especially Russsian-language) literature of the game.

Currently, Griffin isworking on a redesigned and extended version of the original tournament book in the English language in collaboration with Chess Informant. He kindly provided the following decisive game with the annotations as they will appear in the book.

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50 Years Ago Today, USSR-Rest Of The World Started - Chess.com

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The game of war – TheArticle

Posted: at 7:06 pm

It might seem strange, given that the point of chess is to win the game by playing the objectively best moves, that chess writing and subjective chess style can reflect the spirit of the time, the Zeitgeist, as our German friends would put it. Thus Wilhelm Steinitz, undisputed World Chess Champion from 1886 to 1894, sought to codify the correct chess strategies and positional elements, in a series of publications and commentaries which mirror similar sweeping, if pseudo-scientific, pronouncements by other prominentintellectuals ofthat period. In his games across the board, Steinitz doggedly, some would say dogmatically, defended his published theories against the most illustrious opponents of his day in a series of epic matches for the world championship.

In a previous column I drew attention to the English historian Thomas Henry Buckle, who, in the same codifying vein, set himself the ambitious goal of writing the history of civilisation. Even more influential, in terms of their impact on our modern world, were Karl Marx in the field of economic theory, and Sigmund Freud, in the arena of human psychology. It also seems to me no accident that Steinitz, Marx and Freud, this triumvirate of towering intellectuals, were all of German/Jewish origin, and coincidentally, all three found refuge in London at pivotal moments of their careers.

In support of my argument that chess style and literature can reflect its time, consider the prime mode of land warfare from 1914-1918, certainly on the western front. The preferred modus operandi on both sides was attrition, based on the creation of an immense network of blockading trenches, stretching in an unbroken line from the Channel coast to the frontier of Switzerland.

Meanwhile, at sea, after the seemingly indecisive Battle of Jutland, the Kaisers High Seas Fleet, under the command of Admirals Scheer and Hipper, no longer dared to venture forth from its harbour at Wilhelmshaven, thus permitting the British Grand Fleet, led by Admirals Jellicoe and Beatty, to institute a parallel naval blockade. The overall effect of the combined terrestrial and maritime blockade was to starve the Central Powers of supplies, munitions and food, reducing them by 45 per cent from pre-war levels. A sad by-product of the blockade for chess was the death by malnutrition of the supremely talented Viennese Grandmaster, Karl Schlechter.

The most striking chess writer of the 1920s was the Latvian/Jewish Grandmaster, Aron Nimzowitsch. At that time the Cuban World Champion, Jose Capablanca, was undoubtedly a greater player, but as a writer he lacked Nimzowitschs epigrammatic wit and powers of description. Nimzowitsch became enormously influential, even inspiring the chess board endeavours of Marcel Duchamp, as I pointed out in an earlier column. And what was Nimzowitschs first foray into shaping the chess thinking of his generation? It was his essay on The Blockade, explaining how to strangle your opponent by attrition and trench warfare. (Die Blockadepublished by Kagans neueste Schachnachrichten). In its pages he first propounded the ringing and memorable phrase, first restrain, then blockade, finally destroy. Die Blockade was the precursor of Nimzowitschs magnum opus, the chess players strategic bible, My System.

In practical combat Nimzowitsch may not have been Capablancas equal, but his record was certainly formidable, taking first prize in such elite tournaments as Dresden 1926 and Carlsbad 1929, in the latter event actually finishing ahead of Capablanca for the first and last time in his career. Nimzowitsch also won the tournament at Copenhagen 1923, where he created the ne plus ultra of blockading victories, with his opponent, the German Grandmaster Fritz Smisch, reduced to utter paralysis on a virtually full board through an inability to make even one remotely sensible move. Smisch was no pushover. Six years later he was even to defeat the nearly invincible Capablanca, yet Nimzowitsch strangled Smisch to death in spectacular style.

So what lessons can chess teach us for the future, for the post pandemic world which will emerge from the trauma of the Coronavirus cataclysm? During the crisis, chess, in common with the weekly shop, has pivoted decisively towards online activity. Last month I reported on the cancellation of the World Chess Championship Candidates Tournament in Ekaterinburg at the halfway stage. Every major chess tournament until the end of the year has now also been scrapped, including the British Championship, the elite Isle of Man Open and the Grand Chess Tour circuit.

However, unlike the postponed Tokyo Olympics, chess can easily be played online. The Four Nations Chess League, essentially the UKs internal team championship, has switched online. Arnold Schwarzenegger has appeared on social media, reliving a somewhat catastrophic loss to Garry Kasparov (given below), engaging in a humorous clash of chess arms with his pet pony Lulu, but above all urging his vast online audience to keep their brains fit and stimulated during the Covid lockdown, by taking up chess:

On Twitter, Schwarzenegger recently tweeted at Kasparov: Thanks for always giving back and teaching chess to kids. Because of your inspiration, chess is part of our after-school programs. Now we have youth chess at every @ArnoldSports festival around the world. I hope to catch up soon & learn more!

Magnus Carlsen, the reigning World Champion, has also announced that he is organising an online tournament for the worlds top eight players, including himself, with a record $250,000 prize fund for an online chess competition. It starts next Friday. Chess.com an online site where anyone can challenge human or computerised opposition, learn about chess strategies, ploys and tactics, and, of course, also follow archived and live Grandmaster games, reports a surge in subscriptions during Corona-bedevilled March, that would normally have taken ten years to achieve. Just checking as I write, I see that no fewer than 134,415 games are currently in progress, 4,453,868 games had been played during the course of the day, and over 30,000,000 subscribers are now site members, of which 39,726 had joined during the day I checked (April 7th).

The audience for chess now exceeds anything ever before seen in the history of the game, and it is all online. It is my view that the indicators from the world of chess plot the future of the world at large. Buy shares in supermarkets with online delivery services, expect online education and personal development resources to explode, look out for an expansion of high quality restaurants introducing home delivery services and watch closely as newspapers wither and media vehicles transfer to online delivery of opinion and information.Indeed, YouTube already boasts more young viewers than all UK terrestrial TV channels combined. As I predicted in an earlier column, TheArticle with its flexibility, up to the minute topical reporting and ability to interact and reflect readers views, represents the future of journalism.

I conclude my horoscope of things to come with a link to Arnold Schwarzeneggers twitter site where one can find the very brief game won by Garry Kasparov against Schwarzenegger, a case of The Terminator Terminated.

Garry Kasparov v Arnold Schwarzenegger 1992

White: Kasparov

Black: Schwarzenegger

1 e4 b6

2 d4 Bb7

3 Bd3 f5

4 exf5 Bxg2

5 Qh5+ g6

6 fxg6 Nf6

7 gxh7+ Nxh5

8 Bg6 checkmate

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Still Stuck In Germany, Anand Joins COVID-19 Initiatives – Chess.com

Posted: at 7:05 pm

Still not able to fly back home and unite with his family, GM Viswanathan Anand has posted a video message related to the COVID-19 crisis as other Indian players are also speaking out.

Anand has now been in Germany for just under a month, unable to travel back to his wife and son in Chennai, India. After providing commentary for Chess.com on the FIDE Candidates tournament from Europe, the five-time world champion now spends his time like so many of us in these strange times, mostly inside hisplace in Frankfurt, where he has spent many weeks when preparing for his world championship matches.

Why Germany? Well, he was supposed to play for his team OSG Baden-Baden in the Bundesliga on March 14and 15, but these playing days and the remainder of the season have been canceled due to the coronavirus crisiswhich also halted normal air traffic between Germany and India.

It's not the first time that Anand has been unable to fly. A decade ago, he intended to take a plane from Frankfurt to Sofia with his team for his world championship match with GM Veselin Topalov, but air traffic in Europe was disrupted due to theeruptions of the Icelandic volcano Eyjafjallajokull. Instead, a van was rented, and after a 40-hour trip, during which his team famously watched the complete "Lord of the Rings" series, he arrived and ended up beating Topalov.

On Monday, the official Twitter account of India's Ministry of Information and Broadcasting posted a tweet with a wonderful video message from Anand, intended for Indian citizens but also valuable for anyone else. In it, he mentions his son Akhil, with whom he is playing on ChessKid every now and then as well.

A transcript of the message:

"Ive now been isolated at home for over two weeks away from my family unfortunately and I know that most of you are doing the same, but I wanted to urge you to continue this till the end of the lockdown. This is very important because everything which seems natural and healthy like having social relationships, meeting people, going out for fresh air actually helps this virus to spread easily. So its very important we do this, and this allows us to help the healthcare workers and the government and all the people who are out there in the front line because we minimize the transmission. We should stay at home, protect ourselves, and protect others by withholding contact, by not shaking hands, by always keeping a few meters distance if you see someone, but most importantly, staying at home we stop the transmission and that is the most important thing we can do.

"We should understand that those who are in the front lines, mainly government workers, people in healthcare, nurses, doctors, people who are getting supplies across, they should work with minimum interference and very often they are working to a plan which may not be evident to us so we should trust them and let them go about their work without asking questions.

"If you can, please donate or find some way of letting these people know how much you appreciate the sacrifice they are doing and how hard it is for them and try to lift their morale a little bit.

"Finally, the most important thing we can do is not to allow ourselves to get depressed. We should try to keep a positive attitude, a little bit of exercise during the day, social contact through the internet or sending each other videos, these are excellent ways to cheer each other up. We have to maintain positivity. My son, for instance, is enjoying these little chances to go to the balcony and show a light or thank our doctors in some other way. These kinds of events, if carefully controlled, are a nice way to maintain positivity. He is also taken to drawing about the coronavirus and its impact on us. Its an interesting way to let out your feelings so I feel that if we can all find our little way of coping, we just need to hang in there, we are more than halfway across the lockdown period, and if we just hang in there we will come out of this well, but this is the crucial moment. This is when we should not relax our efforts. Thank you all."

A day later, Anand suggested a charity via a tweet.

Two of Anand's colleagues have also sent video messages, via the Twitter account of their sponsor, the Oil and Natural Gas Corporation Limited (ONGC).

Here's GM Humpy Koneru:

"This is grandmaster Koneru Humpy, a proud ONGCian. We are one nation, we are one people. Crisis unites us. Adversities strengthen us. In these times of adversity, we salute all the health workers and government agencies, working day and night to save the people. We in ONGC are doing the same, working non-stop in adverse conditions to ensure that energy resources keep flowing and India stands tall in its fight against an unseen enemy. Please follow social distancing norms, stay home, stay safe and follow all government guidelines. We are here to make a difference. Jai Hind!"

And here's GM Krishnan Sasikiran:

"I am Krishnan Sasikiran, Arjuna Awardee and a proud ONGCian. Friends, these are difficult times and the nation needs to be united in this hour of crisis. Our brothers and sisters in the health sector, sanitation, arm forces, media, delivery and other services are working night and day to save lives, harnessing resources to ensure that every citizen is taken care of. We in ONGC are doing the same. Our energy soldiers continue to work night and day in some remote inhospitable locations to ensure India's energy needs are met. These difficult times demand from us to stay home, stay safe, maintain social distance and observe all norms issued by the government. We are here to make a difference. Jai Hind!"

Six of India's best players will offer simultaneous exhibitions on Chess.com to support the Prime Minister's Citizen Assistance and Relief in Emergency Situations Fund. Set to start on Saturday, April 11, at 6 a.m. Pacific Time (14:00 CEST, 6:30 p.m. Indian Standard Time), former world champion GM Viswanathan Anand will be joined by GMs Pentala Harikrishna, Vidit Gujrathi, Baskaran Adhiban, Humpy Koneru, and Harika Dronavalli as they each will offer a twenty-board simultaneous exhibition for donors to take place on Chess.com. Find more info here.

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Earth’s best telescopes have closed, but the hunt for dangerous aster – Astronomy Magazine

Posted: at 7:01 pm

The last known such event happened in Tunguska, Siberia, in 1908. A roughly 120-foot-wide (36.5 m) space rock entered Earths atmosphere at a blistering speed of 33,000 mph (53,100 km/h). The resulting friction heated it to tens of thousands of degrees Fahrenheit. And this, combined with intense pressure, ultimately caused the rock to dramatically explode some 5 miles (8 kilometers) above the ground. The blast, which is estimated to have released as much energy as almost 200 Hiroshima bombs, flattened trees on the ground over an area of roughly 800 square miles (2,100 square kilometers). Some sources suggest that as many as three people died.

Earth got relatively lucky with Tunguska, but that doesnt mean asteroids arent still a major risk to our planet. In 2013, a space rock the size of a house exploded over Chelyabinsk, Russia, injuring more than 1,000 people as a powerful shock wave blew out countless windows, sending out shards of glass and debris. And just last year, one of these city killer asteroids, dubbed 2019 OK, actually passed between Earth and the Moon without astronomers noticing until just before it happened.

The asteroid caught astronomers by surprise because it approached from the direction of the Sun. And, like a baseball player squinting to locate a fly ball on a cloudless day, astronomers struggle to see small, relatively faint objects with our home star in the background.

Earth will get hit with a major asteroid again, its just a question of when.And thats why astronomers think its important to keep a constant watch, even during a pandemic.

Fortunately, theres only a slim chance humanity will have to face two global crises at once. And thats something we can all be happy about right now.

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The Sky This Week from April 10 to 17 – Astronomy Magazine

Posted: at 7:01 pm

Friday, April 10Tonight, try searching out star clusters in Cassiopeia the Queen. This circumpolar constellation is visible all night from much of the U.S. In more southerly states, you can catch the Queen early in the evening as she sets, then again early in the morning before dawn as she rises once more. Seek out the open cluster M103 just 1 east of Delta () Cassiopeiae. This 6'-wide cluster is visible in binoculars; a 4-inch telescope will resolve its brightest stars, while larger apertures reveal more of its scattered components.

From M103, hop a little less than 2 east to NGC 663, another open cluster. This object is much more densely packed than M103, with about 400 stars in a region 0.25 across. Some observers might be able to detect this cluster with the naked eye under excellent conditions, but binoculars or a telescope from any decent observing location should unveil its sparkling beauty.

From NGC 663, backtrack to M103, then swing 3 southwest to reach NGC 457. This uniquely shaped open cluster is called the Owl Cluster or the E.T. Cluster because it resembles an owl with outstretched wings (or the titular alien from Steven Spielbergs 1982 film, with his arms spread wide). Two bright stars are the figures eyes, while the rest of the clusters luminaries spread out to form the body to the northwest.

Saturday, April 11Tomorrow, April 12, marks the 59th anniversary of humanitys first foray into space: the launch of Yuri Gagarin aboard Vostok 1 on April 12, 1961. Today, the anniversary is celebrated worldwide under the title of Yuris Night or the World Space Party. Due to the ongoing coronavirus pandemic, in 2020 the celebration is moving online. You can find more information about the global webcast, which begins tonight (April 11) at 7 P.M. EDT, at https://party.yurisnight.net/globalwebcast.

Now waning after its super appearance last week, an 86-percent-illuminated Moon still makes a great target for both beginner and advanced observers in honor of the space races ultimate goal. Rising in the southeast just after 11 P.M. local time and remaining visible all night, the Moon spends tonight balanced atop the claws of Scorpius the Scorpion. You can find our satellite nearly 7 north of Antares, the scorpions bright red heart.

Sunday, April 12Asteroid 4 Vesta comes within 40' of Epsilon () Tauri tonight. At magnitude 8.4, Vesta is within reach of most binoculars, offering casual observers the chance to spot this main-belt asteroid. Potato-shaped Vesta measures about 300 miles (483 kilometers) across, making it the third-largest object in the main belt.

Scan 4 east of Epsilon to find NGC 1647, an open star cluster containing a few dozen stars between 8th and 11th magnitude. Drop about 3 southeast of Epsilon, and youll spot brilliant Aldebaran, Taurus brightest star. This famous giant is actually a low-level variable star, fluctuating in brightness by about 0.2 magnitude at irregular intervals.

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The Sky This Week from April 10 to 17 - Astronomy Magazine

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Interview: Jim Lovell relives the successful failure of Apollo 13 – Astronomy Magazine

Posted: at 7:01 pm

Lovell: Well, it did become more famous in the beginning, at least in the eyes of NASA. I have to tell you an interesting story. We came back. Its a failure. So the spacecraft, the command module, which was the only thing left of Apollo 13, really, was in a warehouse down in Florida for about six months. Then, they tried to forget about it. They wanted to go on to Apollo 14 and everything like that.

Then France called up, Paris called up, [the] museum at Le Bourget, which was where Lindbergh landed. They asked the Smithsonian, Do you have any space artifacts that we could have in this museum? Then the lights came on in the Smithsonian and also NASA, Well, we can get rid of this spacecraft. So they exiled Apollo 13 to Le Bourget, and it stayed there for 20 years.

About 18 years after that, I had a classmate that went out there and he saw it and he wrote me a letter. He said, Do you know where your spacecraft is? I didnt at that time. No one told me it was in Le Bourget.Then, later on, a year or so later, my wife [Marilyn] and I were in Paris and we went out to this museum, which was at the airfield there, and there we saw it. We walked up to it. It was still on the cradle that they had rolled it in on. It was all by itself, just about, nothing else around it. The hatch was missing. The instrument panel was missing. The seats were missing. The only thing I saw was a piece of paper that was stuck on the side that said, Apollo 13, and gave the names of the three crew members. And then Ron Howard made the movie. Of course they made the movie that was shown in France, and all those French people said, Oh, its out there in Le Bourget. Lets go see it.

Meanwhile, NASA was so embarrassed and the Smithsonian, that a museum out of Hutchinson, Kansas, called the Cosmosphere, offered to go get [it] and bring it back and pay for it and they did. And all those Frenchmen now were mad because they had kept it for 20 years, and now it came back here. [Laughs.]

Astronomy: Do you recall what the first thing you and Marilyn talked about once you returned after Apollo 13? What did that conversation go like? Did [she] encourage you to find a different career path maybe?

Lovell: Well, I have to tell you another interesting story along those lines. About a week or two weeks after we got picked up in Hawaii and then we came back, we had a big press conference of course. All the NASA people came in and all the reporters came in, and TV people and stuff like that, and a lot of the families came in to listen to the whole thing. We were in the auditorium down in the Johnson Space Center. So we started talking about that.

At the beginning of the conference, a reporter asked, Jim, are you gonna ask for another flight? Obviously, this was not successful. Before that, on Apollo 11 [and] 12, management said, Look, if theres a problem with this flight, well get you back and well give you the very next one.

So when that question came up from the reporter, I thought to myself, because management was right behind us, here was the perfect opportunity to put them on the wall and say yes, because they had not talked to us, the 13, just 11 and 12. I was about ready to say something like that when, out in the audience, I saw a hand go up. Then I saw it go down like this. [Jim gives a thumbs down gesture.] It was my wife. [Laughs.] I could tell. I said, No. I think this is the last flight Im gonna make. [Laughs.]

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Better Predicting the Unpredictable Byproducts of Genetic Modification – NC State News

Posted: at 6:58 pm

Researchers are interested in genetically modifying trees for a variety of applications, from biofuels to paper production. They also want to steer clear of modifications with unintended consequences. These consequences can arise when intended modifications to one gene results in unexpected changes to other genes. A new model aims to predict these changes, helping to avoid unintended consequences, and hopefully paving the way for more efficient research in the fields of genetic modification and forestry.

The research at issue focuses on lignin, a complex material found in trees that helps to give trees their structure. It is, in effect, what makes wood feel like wood.

Whether you want to use wood as a biofuel source or to create pulp and paper products, there is a desire to modify the chemical structure of lignin by manipulating lignin-specific genes, resulting in lignin that is easier to break down, says Cranos Williams, corresponding author of a paper on the work and an associate professor of electrical and computer engineering at NCState. However, you dont want to make changes to a trees genome that compromise its ability to grow or thrive.

The researchers focused on a tree called Populus trichocarpa, which is a widely used model organism meaning that scientists who study genetics and tree biology spend a lot of time studying P. trichocarpa.

Previous research generated models that predict how independent changes to the expression of lignin genes impacted lignin characteristics, says Megan Matthews, first author of the paper, a former Ph.D. student at NCState and a current postdoc at the University of Illinois. These models, however, do not account for cross-regulatory influences between the genes. So, when we modify a targeted gene, the existing models do not accurately predict the changes we see in how non-targeted genes are being expressed. Not capturing these changes in expression of non-targeted genes hinders our ability to develop accurate gene-modification strategies, increasing the possibility of unintended outcomes in lignin and wood traits.

To address this challenge, we developed a model that was able to predict the direct and indirect changes across all of the lignin genes, capturing the effects of multiple types of regulation. This allows us to predict how the expression of the non-targeted genes is impacted, as well as the expression of the targeted genes, Matthews says.

Another of the key merits of this work, versus other models of gene regulation, is that previous models only looked at how the RNA is impacted when genes are modified, Matthews says. Those models assume the proteins will be impacted in the same way, but thats not always the case. Our model is able to capture some of the changes to proteins that arent seen in the RNA, or vice versa.

This model could be incorporated into larger, multi-scale models, providing a computational tool for exploring new approaches to genetically modifying tree species to improve lignin traits for use in a variety of industry sectors.

In other words, by changing one gene, researchers can accidentally mess things up with other genes, creating trees that arent what they want. The new model can help researchers figure out how to avoid that.

The paper, Modeling cross-regulatory influences on monolignol transcripts and proteins under single and combinatorial gene knockdowns in Populus trichocarpa, is published in the journal PLOS Computational Biology. The paper was co-authored by Ronald Sederoff, a professor emeritus of forestry and environmental resources at NCState; Jack Wang, an assistant professor of forestry and environmental resources at NCState; and Vincent Chiang, a Jordan Family Distinguished Professor Emeritus and Alumni Outstanding Research Professor with the Forest Biotechnology Group at NCState.

This work was supported by the National Science Foundation Grant DBI-0922391 to Chiang and by a National Physical Science Consortium Graduate Fellowship to Matthews.

-shipman-

Note to Editors: The study abstract follows.

Modeling cross-regulatory influences on monolignol transcripts and proteins under single and combinatorial gene knockdowns in Populus trichocarpa

Authors: Megan L. Matthews, Ronald Sederoff and Cranos M. Williams, North Carolina State University; Jack P. Wang and Vincent L. Chiang, Northeast Forestry University, Harbin, China, and North Carolina State University

Published: April 10, PLOS Computational Biology

Abstract: Accurate manipulation of metabolites in monolignol biosynthesis is a key step for controlling lignin content, structure, and other wood properties important to the bioenergy and biomaterial industries. A crucial component of this strategy is predicting how single and combinatorial knockdowns of monolignol specific gene transcripts influence the abundance of monolignol proteins, which are the driving mechanisms of monolignol biosynthesis. Computational models have been developed to estimate protein abundances from transcript perturbations of monolignol specific genes. The accuracy of these models, however, is hindered by their inability to capture indirect regulatory influences on other pathway genes. Here, we examine the manifestation of these indirect influences on transgenic transcript and protein abundances, identifying putative indirect regulatory influences that occur when one or more specific monolignol pathway genes are perturbed. We created a computational model using sparse maximum likelihood to estimate the resulting monolignol transcript and protein abundances in transgenicPopulus trichocarpabased on targeted knockdowns of specific monolignol genes. Using in-silicosimulations of this model and root mean square error, we showed that our model more accurately estimated transcript and protein abundances, in comparison to previous models, when individual and families of monolignol genes were perturbed. We leveraged insight from the inferred network structure obtained from our model to identify potential genes, including PtrHCT, PtrCAD, and Ptr4CL, involved in post-transcriptional and/or post-translational regulation. Our model provides a useful computational tool for exploring the cascaded impact of single and combinatorial modifications of monolignol specific genes on lignin and other wood properties.

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Better Predicting the Unpredictable Byproducts of Genetic Modification - NC State News

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Fiction about pandemics and dystopian future – Dhaka Tribune

Posted: at 6:58 pm

Sales of fiction about epidemics have increased considerably in recent months, suggesting that readers are leaning to themes of the moment. The list below offers you a look at a few books prominent for their theme of a pandemic:

Blindness by Jos Saramago

Blindness tells the story of an epidemic that spreads in a European city where the inhabitants start losing their sight. Like any mysterious contagious outbreak, this plague sets off panic, chaos and confusion, and violence. Government quarantines the early-infected people in an abandoned mental asylum and the army guarding it shoots anyone trying to escape. The quarantine camp soon becomes a living hell. The meager supply of food and civil amenities with no one to guide the inmates through their dark world reduce them to bare animals. But the real hell breaks loose when there is a fire in the asylum and the inmates burst forth.

The Painted Veil by Somerset Maugham

This novel is set in the rural China, the heart of a cholera epidemic in the 1920s. Unfaithful Kitty Fane, betrayed by her lover is compelled to go to China with her forgiving husband Walter Fane, who is a bacteriologist and physician. Walter dedicates himself to the service of the cholera affected people risking his life. He falls ill while experimenting on himself to find a cure for cholera and eventually sacrifices his life.

The Painted Veil explores human beings capacity to love, forgive, sacrifice and transform.

The Plague by Albert Camus

Set in the plague-infested French-Algerian city of Oran in the 1940s, The Plague keeps faith in humanity and reaffirms that there is more to admire than to despise in humans. When two doctors approach the town authorities to warn that the town may be in the brink of an epidemic, the authorities fail to understand the gravity of the situation and take it as a false alarm. Eventually, situation worsens and the plague-decimated city is sealed off and the inhabitants are quarantined. Many people come forward to combat the plague, though their motivations differ. While some join the voluntary service being driven by religious principles, the others are motivated by code of morals. The main character of this novel, Dr Bernard Rieux does not serve the victims out of any altruistic or religious obligation. He relieves peoples suffering simply because thats what his job is.

The Stand by Stephen King

Its a post-apocalyptic 1978 novel that narrates the story of a pandemic that wipes out most of the human race. It shows that a computer error in a defense department laboratory leads to the spread of a deadly super-flu. A patient escapes from a biological testing facility, unknowingly carrying an extremely contagious and lethal biological weapon that causes death of 99 percent of the world population. The rest are left to struggle to cope with this new world.

Oryx and Crake by Margaret Atwood

Margaret Atwoods Oryx and Crake is a 2003 post-apocalyptic dystopian fiction, the first volume of her MaddAdam trilogy. It tells the story of a world ravaged by genetic engineering. BlyssPluss, a wonder drug promising health and happiness, causes a pandemic that wipes out the human race. Snowman, presumably, the last surviving human being on earth, lives near a group of bioengineered primitive human like creatures called Crakers, named after their creator, Crake.

Love in the Time of Cholera by Gabriel Garcia Marquez

Plagues are like imponderable dangers that surprise people,, the author of Love in the Time of Cholera, Gabriel Garcia Marquez, told the New York Times in a 1988 interview.Set in the backdrop of cholera outbreak in Cartagena, this novel parallels between the symptoms of love and cholera. Dr Juvenal Urbino, one of the three major characters of this triangular love story, is committed to the eradication of cholera from the town. But there is another type of cholera that no medicine can cure. His wife Fermina Dazas lover Floretino Ariza suffers from the sickness of unrequited love for 50 long years. Here, lovesickness has been compared to an illness, as debilitating and deadly as cholera.

The Eyes of Darkness by Dean Koontz

Published in 1981, The New York Times Best Seller author Dean Koontz thriller novel The Eyes of Darkness tells the story of a mother grieving her sons death. When she finds a strange message claiming that her son is alive, she sets off on a terrifying journey to find the truth. This novel mentions a biological weapon called Wuhan-400 created in China aimed to wipe out an entire city or a country. This virus has a mortality rate of 100% and kills the affected in less than 24 hours.

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Fiction about pandemics and dystopian future - Dhaka Tribune

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David Lynch believes the world will be a more spiritual, much kinder place after lockdown ends – Far Out Magazine

Posted: at 6:57 pm

David Lynch has been the name on everybodys lips of late. The Twin Peaks director has been under the spotlight for his damn fine creation, as it enjoyed its the 30th birthday this week.

It has seen the auteur be interview by Vice in relation to the big day but also to get his feelings and thoughts on the ongoing coronavirus pandemic. The response was one of hope that following the lifting of lockdown restrictions, when we can all share our time with one another again that the world will be a more spiritual, much kinder place to be.

Lynch has been, like many of us, holed up in his Los Angeles home over the past few weeks. While some have struggled to adjust, for Lynch, it has been very similar to his normal day. My routine is pretty much the same now as it was before, Lynch said. I get up, and I get a coffee. After that, I meditate and then I go to work.

All those getting excited about a new film or television project will probably be disappointed. The director has instead been working on two wall sconcestwo little lamps. It involves lightbulbs, electricity, polyester resin plastic, and those kinds of things.

In the current climate, working with electricity and the connection it can bring to those more lonely than others, has been an awakening for Lynch. For some reason, we were going down the wrong path and Mother Nature just said, Enough already, weve got to stop everything, reflected Lynch about the ongoing pandemic.

This is going to last long enough to lead to some kind of new way of thinking.

Lynch believes that the world will emerge from quarantine as more spiritual and much kinder humans. He continued, Its going to be a different world on the other side and its going to be a much more intelligent world. Solutions to these problems are going to come and lifes going to be very good. The movies will come back. Everything will spring back and in a much better way probably.

We can all hope.

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David Lynch believes the world will be a more spiritual, much kinder place after lockdown ends - Far Out Magazine

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Tension Builds Over Drug To Treat COVID-19 – caribbeannationalweekly.com

Posted: at 6:57 pm

MIAMI, Florida With coronavirus (COVID-19) cases increasingdramatically in the United Statessome 435,000 cases as of Thursdaythe nation now has the most cases globally and is desperate for a drug to effectively treat the virus.

Unlike other forms of coronavirus, like the common cold and influenza, there is yet no proven medication to treat COVID-19. The possibility of a vaccine to treat the virus is at least a year away, according to most scientists best estimates.

In recent weeks, there have been claims, including from President Donald Trump and members of his administration, that a drug, hydroxychloroquine, normally used to treat malaria and lupus, is effective in treating COVID-19.

Two weeks ago, Trump at one of his coronavirus task-force press conferences, optimistically said the drug has potential as a drug to treat COVID-19. However, at the same press conference the top U.S. infectious disease expert, Dr. Anthony Fauci, while agreeing that the drug could have a positive effect with COVID-19 patients, cautioned that it needed to be tested before it can be generally prescribed for coronavirus.

Last Sunday at another coronavirus task-force press conference, President Trump again touted the use of hydroxychloroquine to treat COVID-19 although testing of the drug hasnt been completed.

What do I know, Im not a doctor, Trump said Sunday. But I have common sense. In promoting the use of the drug, the president has often stated, What have you got to lose?

One of the Trump administrations strongest backersof the drug is Trade Adviser Peter Navarro, who according to reports that surfaced after Sundays press conference, clashed with Dr. Fauci over the use of the drug. Dr. Fauci continuesto be concerned about recommending the drug based only on unscientific, or as he puts it anecdotalevidence.

Navarro, on the other hand, despite not having formal medical training, claimed in a CNN interview on Monday that reports of studies on the drugs use, which he had collected, were enough to recommend the drug widely.

The American Medical Associations president, Dr. Patrice Harris, also said she wouldnt prescribe the drug for coronavirus patients, because the risks of severe side effects were great and too significant to downplay without large studies showing the drug is safe and effective for such use.

Nonetheless, some doctors are actually prescribing Hydroxychloroquine to patients with COVID-19. Research studies are now beginning to test if the drugs truly help COVID-19 patients, and the Food and Drug Administration has allowed the medication as an option for doctors to consider for patients who cannot get into one of these studies.

Dr. Harris and other doctors claim the drug has serious side effects, especially affecting the heart rhythm, and still want more testing conducted before its clear that the drug works against the virus and where the side effects are concerned.

Cubas Interferon Alpha 2B

Meanwhile, a drug developed in Cuba has been proving to have positive results in treating COVID-19 patients. The drug, Interferon Alpha 2B, is among 22 drugs developed in Cuba since 1986 by its Center for Genetic Engineering and Biotechnology (CIGB) and used as a treatment for HIV-AIDS, hepatitis B and C, herpes zoster or shingles, dengue and different types of cancers.

It is also highly recommended by medical specialists for its ability to fight the COVID-19 virus. During the onset of the virus in Wuhan province, the Chinese authorities found it exceptional in destroying the virus from thousands of its citizens who contracted the disease at the earliest stages.

Since the success of this antiviral drug has become public knowledge, Cuba has been flooded with requests from across the globe, including, Africa, Europe, Latin, and South America and Caribbean nations.

Evidence tuberculosis vaccine BCG prevents COVID-19 infection

Recently reports surfaced that the BCG vaccine given to counter tuberculosis (TB) may provide protection against COVID-19 and significantly reduce death rates in countries, including most Caribbean countries,with high levels of this vaccination.

A study of 178 countries conducted by an Irish medical consultant in conjunction with epidemiologists at the University of Texas indicated countries with BCG vaccination programs have far fewer coronavirus cases by a factor 10, compared to countries without such programs.

The BCG vaccine is still widely used in developing countries, where scientists have found, along with preventing TB, it alsoprevents infant deaths from a variety of causes, and sharply reduces the incidence of respiratory infections like the coronavirus.

Most Caribbean-Americans residing in South Florida bearthe scars of the BCG vaccine on their upper arms, as the vaccine was and still is mandatory for attending public schools in the Caribbean.

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Tension Builds Over Drug To Treat COVID-19 - caribbeannationalweekly.com

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