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Monthly Archives: April 2020
Turning the Tide Lifestyle Medicine and Breast Cancer (Part 6) – South Coast Herald
Posted: April 6, 2020 at 5:05 pm
Dr David Glass - MBChB, FCOG (SA)
Today we celebrate our 100th blog on the subject of lifestyle medicine making wise choices in the area of diet, exercise, rest, sunlight, fresh air, water, relationships and spiritual connection. This is one area of medicine that seems to permeate all others. It is becoming increasingly important as diseases of poor lifestyle choices affect more and more people around the world resulting in rising incidences of heart disease, high blood pressure, diabetes, obesity, auto-immune diseases, cancer and dementia.
ALSO READ : Turning the Tide Lifestyle Medicine and Covid 19
Of course our minds are daily preoccupied with Covid-19, and so should they be. We are facing one of the most devastating challenges to health care and the economy the world has seen this century. Two weeks ago I presented a lifestyle approach to this pandemic, because we know that the virus is particularly aggressive in people who suffer chronic lifestyle diseases.
Today we will get back to our topic for this series breast cancer. Unfortunately Covid-19 doesnt make all the other diseases, to which we are so prone, go away. As mentioned before, this series is based on Dr Kristi Funks book Breasts: The owners manual. This week we will be looking at uncontrollable risk factors.
Next week we will briefly look at some of the interventions on offer in terms of treatment and screening to complete the series on breast cancer.
Stay safe, isolated as much as possible in your home. May you use this time for building family relationships and getting life priorities right. It is good to have some forced time for reflection when we are faced with the prospect of our own mortality or that of our friends and family.
Dave Glass
Dr David Glass MBChB, FCOG (SA)
Dr David Glass graduated from UCT in 1975. He spent the next 12 years working at a mission hospital in Lesotho, where much of his work involved health education and interventions to improve health, aside from the normal busy clinical work of an under-resourced mission hospital.
He returned to UCT in 1990 to specialise in obstetrics/gynaecology and then moved to the South Coast where he had the privilege of, amongst other things, ushering 7000 babies into the world. He no longer delivers babies but is still very clinically active in gynaecology.
An old passion, preventive health care, has now replaced the obstetrics side of his work. He is eager to share insights he has gathered over the years on how to prevent and reverse so many of the modern scourges of lifestyle obesity, diabetes, ischaemic heart disease, high blood pressure, arthritis, common cancers, etc.
He is a family man, with a supportive wife, and two grown children, and four beautiful grandchildren. His hobbies include walking, cycling, vegetable gardening, bird-watching, travelling and writing. He is active in community health outreach and deeply involved in church activities. He enjoys teaching and sharing information.
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Indians seem to have genetic and regional advantages in fight against coronavirus – ThePrint
Posted: at 5:05 pm
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The coronavirus disease (Covid-19) first appeared in the Wuhan district of Hubei province of China in early December 2019. The first case was reported by China on January 7, 2020, and this aroused variable interest worldwide, with most countries initially ignoring the novel infection. Fortunately, Indian health authorities sensed the danger, largely because the country has always been alert to new infections. The scientific think-tank at the Indian council of Medical Research (ICMR) became active immediately and the first laboratory confirmed case was identified at ICMRs National Institute of Virology (NIV), Pune, sometime towards the end of January.
A look at the world Covid meter shows that there is striking variation in mortality rates across countries, ranging from 0.2% to 15% depending on age, the smoking habit and pre-existing co-morbidities. It may be too early to tell, but in general, countries in the Northern hemisphere have faced the maximum brunt, and those in the Southern hemisphere (and those located proximate to the Equator) have so far escaped high infection numbers.
Three factors seem to be playing a role in the observed lower numbers in India with almost zero occurrence of severe Covid-19 cases (until now). First, broad-based immunity in the population due to the extensive microbial load. The Indian population has been exposed to a vast variety of pathogens, including bacteria, parasites and viruses leading to the generation of broad specific memory T-cells in the system, ready to attack additional foreign invaders.
For example, the three main killers of Tuberculosis, HIV and Malaria have plagued India, Africa and several countries in the Southern hemisphere much more than the European and North American nations. In the context of CoV-2 coronavirus, the beneficial role of chloroquine and hydroxychloroquine has been much talked about and debated, while there has already been an extensive usage of this drug at the community level in India this too may ultimately prove beneficial.
Also read: In fight against coronavirus, India has age on its side. Numbers show
Second, epigenetic factors that include environment and food habits may also play a beneficial role for countries such as India; much literature is already available in Ayurveda and other Indian systems of medicine on the definitive beneficial effects of Indian spices in augmenting immunity.
Third, and most important, is the possible role of immune response genes in the Indian population. These genes are collectively referred to as comprising the human leucocyte antigen system or simply, the HLA genes. Their main biological function is to present invading foreign antigens to the immune systems, since T-cells, which act as the bodys soldiers come into play only when pathogens are presented to them in a more formal manner in association with HLA genes. In other words, the pathogen must first attach to compounds created by HLA genes before T-Cells attack it. If no such compounds are produced by the body, then the T-Cells are ineffective. As a consequence of the microbial load, the Indian population possesses a high genetic diversity of HLA, much more extensive than Caucasian populations. Indeed, studies by the author at the All India Institute of Medical Sciences, New Delhi, over several decades revealed the presence of several novel HLA genes and their alleles in the Indian population, most of which do not occur in other ethnic groups. Such genetic diversity of HLA could affect viral fitness.
The question then is:Why should genetic variation in HLA genes play a role in the Covid-19 progression? One hint comes from earlier studies in related viral diseases: Certain genetic variants of the HLA system provide protection against such viruses, while others increase genetic susceptibility to them. Another source of indirect evidence comes from recent clinical Covid-19 studies which showed that rapid T-cell response appears to be crucial for recovery from Covid-19, and reduced functional diversity of T cells in peripheral blood could predict progression of Covid-19.
The big question is:Does this give Indians a better chance at fighting the virus effectively? From the epidemiological data so far, it seems so (although much more extensive research is required). However, it is important for us to keep viral loads in check and below the threshold levels. In this context, the complete lockdown announced by the government is highly timely and most desirable. It is imperative that the virus replication cycle gets disrupted as early as possible before it gains numbers that may become difficult for us to counter.
To this end, the images of crowds gathering in several places whether for panic buying or interstate movements are disturbing. They could jeopardise all efforts and mitigate whatever natural advantages we enjoy.
The State must act fast to enforce the lockdown, even forcibly if necessary. India may be the outlier in fighting the coronavirus infection and succeed in keeping the overall numbers lower than the rest of the world with minimal deaths.
Narinder Kumar Mehra is the ICMR National chair and former Dean of the All India Institute of Medical Sciences, New Delhi
The views expressed are personal
By special arrangement with
Also read: Indias fight against Covid-19 needs wartime industrial production, not more red tape
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Optics, Photonics and COVID-19 – Optics & Photonics News
Posted: at 5:05 pm
[Image: Getty Images]
As the COVID-19 pandemic spreads across the world, patients, technicians and scientists depend on state-of-the-art molecular-analysis instruments as they fight against SARS-CoV-2, the virus causing this disease. Optics and photonics technologies embedded in these instrumentssuch as high-quantum-efficiency multispectral cameras, visible-light laser diodes and LEDs, infrared bolometer arrays, narrowband optical filters and wideband multispectral optical spectrometersplay an essential part in the story.
Whether in the hospital or in the lab, optics technologies make possible rapid preliminary screening of potentially infected individuals, more accurate molecular diagnosis, reliable monitoring of disease progression and even, potentially, disinfection of contaminated surfaces. Our community developed these enabling technologies over the past several decades for applications ranging from telecommunications to machine and night vision. Now, theyre playing a life-saving role in the battle against SARS-CoV-2.
Early detection of infected patientsone of the primary challenges of the COVID-19 pandemicis complicated by the wide variability in the diseases symptoms. Monitoring for an increase in body temperature is the most commonly used preliminary screen. Under normal circumstances, direct body-cavity temperature measurements are the most accurate way to monitor a fever; however, given the pathogenicity of SARS-CoV-2, remote, non-contact options that employ infrared imaging cameras to simultaneously image and measure groups of individuals provide a significant safety advantage.
Many clinicians now rely on infrared-based thermometers for measuring forehead temperature. These imaging and spot-measurement thermometric devices provide medical personnel with a safer and useful non-contact patient screen. These thermometers are based on single detectors or arrays of MEMS-based microbolometers or semiconductor diode detectorsthermal sensors that are sensitive in the far-infrared spectral region (8 to 14 m) and detect changes in the blackbody radiation intensities in persons with above-normal body temperatures.
Cepheid doctors office RT-PCR instrument. [Image: Courtesy of Cepheid]
In TaqMan real-time polymerase chain reaction, a nucleic-acid probe molecule, tagged with a fluorescent molecule and an accompanying quencher, attaches to the stretch of DNA or RNA being copied. With each round of amplification, the fluorescent molecule is released into the buffer solution and separated from the quencher, allowing the amplification of the targeted genetic sequencesuch as one from SARS-CoV-2to be detected via fluorescence in real time. [Image: Wikimedia Commons]
If a patient presents with a fever or other symptoms typical of viral infection (sore throat, dry cough, muscle aches and fatigue), the next step is a molecular diagnostic test. This screen, based on a technique called real-time reverse transcription polymerase chain reaction (RT-PCR), uses sensitive spectroscopic methods to detect extremely small quantities of viral genetic material from a patients nasal or throat swab. And once again, optical technology is an essential component for disease detection.
The diagnostic procedure requires significant sample processing, beginning with a specimen collected from a patient. Real-time RT-PCR works by copying specific nucleic acid sequences within that sample, using probesnucleic-acid primersthat selectively bind very specifically to the RNA sequences present in the SARS-CoV-2 virus. The probes are tagged with molecules of fluorescent dye.
Enzymes are then used to copy the nucleic-acid sequences bound to the probes. The sample is thermally cycled roughly 40 times between37 C and 95 C. If the target nucleic-acid sequences are present, they are amplified twofold with each cycle.
It is optical technology that puts the real time in RT-PCR. As the amplification enzymes create the duplicate copies, the fluorescent molecules are released into the buffer solution. The overall fluorescence is measured in real time after each cycle, increasing as the number of amplicons increases for positive samples. By measuring the intensity buildup during the thermal cycling, the virus is detected and the amount of virus present (the viral load) can be estimated.
Real-time RT-PCR instruments employ narrowband visible laser diodes or LEDs as excitation sources and semiconductor diodes or photomultipliers with narrow band-pass optical filters for detection. These instruments are fully automated and can typically process 96 or 384 samples in parallel in less than an hour.
Real-time RT-PCR is one of the most sensitive and specific molecular-analysis techniques available today. This assay is crucial for tracking and controlling the spread of COVID-19. However, the overall sensitivity of the method may be limited by the efficiency of the sample collection and preparation process. The amount of virus present in the sampled tissue, which varies between individuals and as the disease progresses in each patient, may also be a limiting factor.
The false-negative rate of this approach is currently estimated at roughly 30%. Repeated testing can reduce this admittedly significant percentage, which is why many hospitals require two or three sequential negative real-time RT-PCR tests after a patient has recovered before that patient is classified as non-infectious.
In addition to molecular diagnostics, imaging of the lungs of COVID-19 patients has also proved very sensitive for detecting SARS-CoV-2 infection using high-resolution computed tomography (CT) scans. Clinicians look for signs of lung damage as evidenced by ground-glass patterns in the lung tissue or fluid accumulation as signatures of pneumonia. Clinics in China have reported that this approach can detect a significant number of infected individuals that have negative RT-PCR readingsonly, however, later in disease progression, once lung damage manifests.
If a patient is diagnosed with COVID-19, disease progression and respiratory function are determined using an oxygen-saturation meter, which measures the percentage of oxygenated hemoglobin in blood. As the disease progresses, breathing can become difficult, causing a reduction in oxygenated hemoglobinif levels dip below certain thresholds, then supplementary oxygen or a ventilator may be warranted.
Oxygen-saturation devices use LEDs emitting at two different wavelengths, typically around 665 nm and 894 nm. The oxygen-saturation percentage is measured from the ratio of the absorption at these two wavelengths. These battery-powered devices fit comfortably on a finger or toe, providing real-time measurement of oxygen-saturation levels.
96 sample well plate ELISA instrument. [Image: 2020 Berthold Technologies. Used under permission. http://www.berthold.com]
Schematic of ELISA, which measures the presence of specific antibodies in a COVID-19 patients sample. The technique relies on a colorimetric change in the sample generated by an enzyme attached to antibodies specific to SARS-CoV-2 virus. [Image: Cavitri/Wikimedia Commons, CC-BY 3.0]
Optical instruments are also used to test whether a person has been exposed to SARS-CoV-2 virus and has developed an immune response. These instrumentswhich can be automated to analyze hundreds to thousands of samples per dayuse a technique called an Enzyme-Linked Immunosorbent Assay (ELISA) to measure the presence of antibodies specific to the SARS-CoV-2 virus in a patients blood-serum sample.
In a typical assay, an antigen found on the virus surface is immobilized on the bottom of a sample well, which is optically transparent. Antibodies in the serum sample are attached to an enzyme (typically horseradish peroxidase) and allowed to incubate on the surface containing the immobilized antigen. Any antibodies specific for the SARS-CoV-2 antigen bind to the target and become immobilized on the surface of the optical window. The unbound, nonspecific antibodies are washed off.
A solution containing the enzymes substrate with a colorimetric indicator is then added to the sample well, and the enzyme linked to the antibody reacts with the substrate, producing a color change in the sample. The enzyme reacts with multiple substrate molecules, thereby amplifying the signal. SARS-CoV-2 antibodies in the blood serum can then be detected and quantified, via multispectral imaging of the sample substrates fluorescence or absorption indicator.
This approach is used to measure the extent of the virus spread within a community, even after the pandemic has passed; to measure the duration of an individuals immune response; and to investigate the efficacy of antiviral drug candidates and potential vaccines. Currently, medical workers who have recovered from COVID-19 and have a protective immune response to the virus are being identified using an ELISA. Once immunity is confirmed, these personnel safely resume working with infected patientsa common approach in pandemic medicine.
Optical devices also form the core technology for the most common high-throughput gene-sequencing instruments. These typically use high-quantum-efficiency, very-high-resolution multispectral cameras to map the sequences of hundreds of millions of target DNA molecules simultaneously and can sequence the complete genome of the SARS-CoV-2 virus in just a few hours. Virus genetic sequences can vary with location, since the SARS-CoV-2 virus occasionally mutates during its replication phase. Infections in separate geographic regions can be compared, and the origins of infections traced, by comparing the specific mutations in samples taken from patients in different locations.
High-throughput sequencing of the virus genome also can determine the proteins in the virus and identify suitable targets for synthetic vaccines that will safely stimulate immune response. This technology has greatly improved over the past 20 years, largely due to the human genome project, and will be an essential tool for developing effective vaccines and antiviral drugs to combat the COVID-19 pandemic.
Prototype of an LED sterilization system being tested by Bolb Inc. [Image: Bolb Inc.]
Beyond the molecular-biology lab, optics is emerging as a weapon on another vital front: the sterilization of surfaces. Most viruses and bacteria are very sensitive to ultraviolet light, particularly in the UV-C spectral region (200280 nm), which causes mutations in the RNA that is essential for viral replication. Recently, great progress has been made in the development of UV LEDs that emit in this region. LED arrays emitting hundreds of milliwatts have been developed with lifetimes of over 1000 hours and electrical efficiencies around 10%.
Arrays of these diodes can generate significant UV power levels to potentially decontaminate certain surfaces more efficiently than chemical reagents. Recent lab results indicate that exposure times of about 1 minute were sufficient to kill bacteria and viruses with a 1-W-average-power device located about 1 meter above a contaminated surface. Further testing on the efficacy of UV LEDs for decontaminating surfaces infected with SARS-CoV-2 virus is in progress.
As global health faces this novel and deadly threat, laboratories around the world are using technologies developed by the optics and photonics community to help stem the spread and save lives. In the near future, as social distancing begins to slow the spread of COVID-19 disease, medical focus will shift to the early detection and isolation of COVID-19 recurrence in hot spots, which will present new challenges for diagnostic and decontamination technologies. These challenges represent new opportunities for optics and photonics technologieswith their advantages of low cost, high speed, sensitivity and specificityto make major contributions to global health. OPN
Note: This article will also be published in the May 2020 issue of Optics & Photonics News.
2009 OSA President Thomas M. Baer (tmbaer@stanford.edu) is with Stanford University, USA. Christina E. Baer is with the University of Massachusetts Medical School, USA.
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3 ‘Mental Hacks’ To Improve Focus That Every Entrepreneur Should Know – Entrepreneur
Posted: at 5:05 pm
April6, 20205 min read
Opinions expressed by Entrepreneur contributors are their own.
You're reading Entrepreneur India, an international franchise of Entrepreneur Media.
When it comes to being an entrepreneur, the focus and productivity levels will make or break you. Even just a 10 per cent advantage can be the difference between a wildly successful initial public offering, and having to close up shop.
With such wild competition in the business world, being able to focus and improve productivity are becoming more and more importantand as the world becomes more globally connected, your competition will only grow fiercer.
Any entrepreneur knows this, and were also willing to do whatever it takes to succeed. So, with that in mind, here are the top mental hacks that every entrepreneur who wants her business to succeed should know.
Its no secret that Silicon Valley executives have been using nootropics like modafinil for years to gain an edge in the market. What most people dont know, however, is that theres many other nootropics available to use, as well.
While the idea of using nootropics to boost productivity, improve focus, and increase energy levels might be off-putting to some, theres a lot of clinical research to back the effectiveness of nootropics.
In fact, according to Healthline, these nootropics have been clinically proven to work, and have several research studies backing their safety and efficacy:
To improve focus, many entrepreneurs use nootropics such as caffeine, nicotine, Noopept, and modafinil to start. While modafinil is only available with a doctors prescription, many of these other nootropics can be bought over the counter.
For memory, others use Bacopa Monnieri, Lions Mane, and Gingko Biloba to gain an edge. While they may not turn you into a genius with superhuman intelligence, even a slight improvement in your memory will yield big results in your business.
Are you tired and stressed from too much work? Then why not try some GABA, Ashwagandha, or 5-HTP, as many entrepreneurs are doing these days. The fact of the matter is that many entrepreneurs are using nootropics to get ahead in the workplace, and if youre not doing so, you may have some fierce competition.
You may or may not have heard of Wim Hof before. If you havent, hes a 58-year-old Dutch man who holds 26 world records for physical feats, one of which is for taking the longest ice bath in the world. Yes, thats rightthis old man was able to spend almost two hours, completely immersed in a bath of ice.
Hes also climbed both Mount Everest and Mount Kilimanjaro while wearing nothing but shorts and a pair of shoes. So, whats the secret to these incredible feats? How does he have such superhuman resistance to cold, despite his age?
He accredits his physical toughness to his Wim Hof Method, which is a series of breathing exercises that flood the brain and body with oxygen. Combined with cold showers, some of the benefits he touts are improved physical performance, reduced anxiety levels, and even improved happiness levels.
While many people are skeptical that simply breathing a different way can yield such incredible benefits, almost everyone who tries his method reports better focus, more productivity, less anxiety, and a whole host of other benefits.
While much has been said about productivity before, most people still waste endless time on menial tasks, like checking emails, browsing social media, and making minor improvements to their business that yield almost no results.
One great concept regarding productivity is based around a book called Focal Point by Brian Tracy. The idea is simple: only focus on the tasks that are going to bring about the most return on your time investment. Despite its simplicity, most people neglect this concept, and focus on low return on investment activities.
The Focal Point System divides tasks into five categories, of descending priority:
An A Task would be something like signing a client onto a $50 million contract, whereas a B Task might be something like going to the gym. Theyre both important, but going to the gym is less impactful on your business.
A C Task would be something along the lines of getting a new client, because even though it may help your business, it isnt necessary if you just get the $50 million contract to begin with. D Tasks and E Tasks are small things, like checking emails, following up on a phone call, or printing out business cards.
Most entrepreneurs focus on the B Tasks, and C Tasks, when they should really be focusing on the A Tasks, and B Tasks. You should aim to either ignore, outsource, or automate everything else, for maximum productivity.
As Steve Jobs once said: People think focus means saying yes to the thing youve got to focus on. But thats not what it means at all. It means saying no to the hundred other good ideas that there are. This could not be more accurate.
One of the biggest keys to productivity is focusing on the 20 per cent of tasks that are going to bring about 80 per cent of your results (also known as the Pareto Principle). By simply viewing the world through this Focal Point System lens, you can easily save hours of time each day, and get twice as much done in half the time.
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Jeffrey Epstein and the Hideous Strength of Transhumanism – National Catholic Register
Posted: at 5:05 pm
Transhumanism rides roughshod over the dignity of the human person in its quest for the technologically created superman.
The sordid life of Jeffrey Epstein serves to highlight the decadence of the deplorable epoch in which we find ourselves, as do the suspicious circumstances surrounding his death. The web of vice and viciousness that he had spun was widespread, serving to entrap not only underage girls but also the rich and famous who preyed upon them. Using the allure of underage sex to lure his wealthy associates into his web, Epstein secretly filmed them in the act of sexually abusing minors, thereby turning his associates into his blackmail victims.
Epstein seems to have believed that the powerful people whom hed entrapped in his insurance policy would have a vested interest in keeping him safe from the law, a strategy which worked for a while. In 2008, Epstein was convicted in Florida of sexually abusing a 14-year-old girl, receiving a scandalously light sentence, but due to a plea deal he was not charged with sexually abusing 35 other girls whom federal officials identified as having been abused by him.
After a further 10 years in which Epstein masterminded the trafficking of young girls to satisfy the pornographic and pedophilic appetites of his powerful network of friends, he was finally charged in July of last year with the sex trafficking of minors in Florida and New York. A month later, he was found dead in his jail cell. Although the medical examiner originally recorded the death as being a case of suicide, there are so many anomalies and mysteries surrounding the circumstances of Epsteins death that many people agree with Epsteins lawyers that the death could not have been suicide. One thing that is certain is that Epsteins death removed the possibility of pursuing criminal charges. There would be no trial, and therefore no exposing of Epsteins powerful associates by their victims in a court of law. Seen in this light, or in the shadow of this possible cover-up, it is tempting to see Epsteins insurance policy as his death warrant. He was too dangerous to be allowed to live when the lives of so many others depended on his timely death. It is no wonder that Epstein didnt kill himself has become a hugely popular meme, nor that HBO, Sony TV and Lifetime are planning to produce dramatic portrayals of Epsteins life and death.
One aspect of Epsteins life which is unlikely to be the focus of any TV drama is his obsession with transhumanism. For those who know little about this relatively recent phenomenon, transhumanism is usually defined as the movement in philosophy which advocates the transformation of humanity through the development of technologies which will re-shape humans intellectually and physiologically so that they transcend or supersede what is now considered human. At the prideful heart of this movement is a disdain for all that is authentically human and a sordid desire to replace human frailty with superhuman or transhuman strength.
Transhumanism rides roughshod over the dignity of the human person in its quest for the technologically created superman. Its spirit was encapsulated by David Bowie in the lyrics of one of his songs: Homo sapiens have outgrown their use Gotta make way for the homo superior.
Most of Epsteins so-called philanthropy was directed to the financing and promotion of transhumanism. The Jeffrey Epstein VI Foundation pledged $30 million to Harvard University to establish the Program for Evolutionary Dynamics and also bankrolled the OpenCog project which develops software designed to give rise to human-equivalent artificial general intelligence. Apart from his support for the cybernetic approach to transhumanism, Epstein was also fascinated with the possibility of creating the superman via the path of eugenics. He hoped to help in a practical way with plans to seed the human race with his DNA by impregnating up to 20 women at a time at a proposed baby ranch at his compound in New Mexico. He also supported the pseudo-science of cryonics which freezes human corpses and severed heads in the hope that technological advances will eventually make it possible to resurrect the dead. He had planned to have his own head and penis preserved in this way.
In addition to his bizarre association with the wilder fringes of technological atheism, Epstein also co-organized a conference with his friend, the militant atheist Al Seckel, who is known, amongst other things, for his creation of the so-called Darwin Fish symbol, seen on bumper stickers and elsewhere, which depicts Darwins superior evolutionary fish eating the ichthys symbol or Jesus fish of the Christians. Seckel fled California after his life of deception and fraud began to catch up with him and he was found at the foot of a cliff in France having apparently fallen to his death. Nobody seems to know whether he slipped, jumped or was pushed.
Apart from his unhealthy interest in atheistic scientism, Jeffrey Epstein was also a major figure amongst the globalist elite. According to his lawyer, Gerald B. Lefcourt, he was part of the original group that conceived the Clinton Global Initiative which works to force the poor countries of the world to conform to the values of the culture of death. Even more ominously, Epstein was a member of the Trilateral Commission and the Council on Foreign Relations, two of the key institutions responsible for fostering and engineering the globalist grip on the worlds resources.
As we ponder the sordid and squalid world of Jeffrey Epstein and his associates, we cant help but see his life as a cautionary tale, the moral of which is all too obvious. It shows that pride precedes a fall and that it preys on the weak and the innocent. It shows that those who think they are better than their neighbors become worse than their neighbors. It shows how Nietzsches Untermensch morphs into Hitlers Master Race and thence to the Transhuman Monster. It shows that those who admire the Superman become subhuman. It also shows that the subhuman is not bestial but demonic. It shows that those who believe that they are beyond good and evil become the most evil monsters of all.
Those of us who have been nurtured on cautionary tales such as Mary Shelleys Frankenstein or C. S. Lewiss That Hideous Strength will know that fiction often prefigures reality. We will see that the real-life figure of Jeffrey Epstein is a latter-day Viktor Frankenstein, reaping destruction with his contempt for his fellow man and his faith in the power of scientism to deliver immortality to those who serve it. We will also see that the transhumanism which Epstein financed is a mirror image of the demonic scientism of the secretive National Institute of Coordinated Experiments in Lewis prophetic novel. We will also be grimly amused by the fact that the leader of the demonic scientistic forces in Lewis tale is a severed head which has apparently been brought back to life.
And there is one final lesson that the pathetic life of Jeffrey Epstein teaches us. It shows us that the adage that the devil looks after his own is not true. It is in fact a lie told by the devil himself. The devil hates his disciples as much as he hates the disciples of Christ; once he has had his way with them, he disposes of them with callous and casual indifference, much as Jeffrey Epstein disposed of those whom he sexually abused.
This essay first appeared in Crisis Magazine and is republished with permission.
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Coffee 3 alternatives to coffee that no one is talking about – Ladders
Posted: at 5:05 pm
If youre like me, you probably reach for at least one cup of coffee every day. Its become a natural part of our routines and for many is a morning staple like taking vitamins or eating breakfast. As the busy-oriented lifestyle continues to consume our society, coffee has been positioned as a magical elixir to help us focus and multi-task.
As comedian Jerry Seinfeld once said, We want to do a lot of stuff: were not in great shape. We didnt get a good nights sleep. Were a little depressed. Coffee solves all these problems in one delightful little cup.
What most people dont realize is that there is a whole world of interesting coffee alternatives that can:
For starters, I firmly believe that coffee can be incredibly beneficial if consumed in moderation. In fact, some scientists are even encouraging people to drink more coffee. Coffee drinkers run into trouble when they get into a habit of five plus cups per day or reach for a Starbucks Java Chip Frappuccino in the evenings.
But youre probably wondering, What else is even out there?
I was initially introduced to several coffee alternatives like nootropics, adaptogens, and mushrooms after reading through Beyond Coffee, a sustainable guide that breaks down different ingredients and analyzes if they are optimal for productivity, scientifically backed by research, and can act as a realistic source of energy.
Everyones heard that green tea is a great coffee substitute for energy and burning fat, but I want to take it one step further and break down a few possibilities to try that you may not be aware of. The three options mentioned below are all extensively detailed in Beyond Coffee, supplements that I take on either a daily or weekly basis, and have been proven to be effective and, more importantly, considered safe if taken within the FDAs recommended dosage.
So, here are a few interesting coffee alternatives for you to consider that no one is talking about.
1. Omega-3 EPA and DHA
Omega-3s fall under the umbrella of nootropics, a growing category of compounds, pills, and powders advertised for their potential to enhance focus and productivity.
Im sure you come across nootropics on a daily basis and have seen them advertised in your local grocery store. While Nootropics arent new, they have become more popular in recent years with users creating a nootropic stack- combining multiple compounds into a cocktail for heightened results. Nootropics include a variety of supplements that have been well-researched and are widely considered safe like matcha green tea or my recommendation, omega-3s, along with other drugs and commercial products that are less effective and possibly unsafe.
Commonly recognized as fatty acids, omega-3s are often derived from consuming fish like tuna and salmon, or taken in a pill form. While most people use omega-3s for eye health and to lower cholesterol and blood pressure, research also shows that increasing your omega-3s may enhance cognitive performance and improve attention span.
There is even evidence to support that omega-3s can slow or reduce the likelihood of brain degenerative diseases. A study on elderly adults followed for nearly four years discovered that those who ate higher amounts of fish and supplemented with omega-3 fatty acids were less likely to develop Alzheimers.
Omega-3s are relatively inexpensive and you can take them daily.
2. L-Theanine
L-Theanine is another nootropic that has been well-researched. If youre someone who associates nootropics with smart drugs like the movie Limitless, you may be disappointed to hear that a lot of nootropics are used for their de-stressing agents and anti-inflammatory properties- not an output of hyper intelligence.
L-Theanine is an amino acid found in fungi, plants, and green tea. This is one of the few supplements that I would recommend taking in addition to caffeine to get the most out of it- but this doesnt necessarily have to be coffee.
According to Beyond Coffee, Theanine is thought to have neuroprotective and cognitive-enhancing effects by increasing serotonin, dopamine, GABA, and glycine levels in the brain. There is also evidence suggesting that L-Theanine will improve your mood and can be used for treating high blood pressure. L-Theanine has been classified by the FDA as generally recognized as being safe or GRAS status.
3. Spirulina
I started using spirulina last year as an addition to my morning protein shakes. Spirulina is a blue-green algae rich in protein, B-vitamins, and iron. Just a single tablespoon is packed with plant-based protein and has been recommended for a variety of conditions including high blood pressure, stress, anxiety, and diabetes.
Regarding energy, Vitamin B1 helps regulate your bodys thiamin (which contributes to fatigue) resulting in a more stable maintenance of energy. Coffee alternatives dont necessarily need to be sharp boosts in attentiveness like the energy provided by caffeine. Instead, a supplement like Spirulina can help you hold onto more energy throughout the day- it has even been shown to improve athletic performance by increasing endurance.
Am I imploring you to delete your Starbucks app and throw the company Keurig in the trash?
Not quite but there are other energy alternatives out there that also offer a multitude of healthy benefits. As always, its important to use supplements as they are intended. They should supplement a healthy diet and physical exercise. A spoonful of spirulina in your orange juice wont make a difference if youre running on two hours of sleep and a Big Mac.
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Weekly Line: The health care industry is betting big on AIbut providers need to understand its limitations – The Daily Briefing
Posted: April 3, 2020 at 1:49 pm
Major players in the health care industry are betting big on artificial intelligence (AI) to revolutionize the way providers care for patients, especially as the world grapples with the new coronavirus pandemic.
How you can use AI to combat Covid-19 right now
Some evidence suggests those bets could pay off, but there's also research suggesting that AI isn't quite mature enough for providers to rely onand particular skepticism about how effectively AI can be used to battle Covid-19. Daily Briefing's Ashley Fuoco Antonelli outlines what we knowand don't knowabout AI in health care.
A recent global funding report on AI by CB Insights showed investors spent $4 billion across 367 deals in the AI health care sector in 2019, up from $2.7 billion across 264 deals in 2018. What's more, investments in health care AI outpaced AI investments for other industries, the report found.
The report also showed that investments in health care AI surged toward the end of 2019, with companies raising nearly $1.6 billion across 103 deals in the third quarter alone.
Further, some big corporations are teaming up with AI startups on health care products. FierceHealthcare's Heather Landi notes, for example, that Microsoft has joined forces with KenSci, which has created a risk prediction platform based on AI and machine learning systems; NVIDIA has teamed up with Paige.AI, which uses AI to study cancer pathology; and Google has partnered with Suki, which has a voice-enabled digital assistant for doctors that runs on AI.
A survey released this month by the audit, tax, and advisory services firm KPMG found that health care CEOs also are adamant about integrating AI into their systemsand about AI's potential to improve health care. Melissa Edwards, managing director of digital enablement at KPMG, in the report said, "The pace with which hospital systems have adopted AI and automation programs has dramatically increased since 2017. Virtually all major health care providers are moving ahead with pilots or programs in these areas."
And a majority of health care leaders believe AI can have a valuable impact for their health systems, Advisory Board research shows. Advisory Board found 37% of leaders in 2018 expected AI technologies could present transformative value to their systems and 27% expected AI would have some incremental value for the systems.
So it's not surprising that, faced with the extraordinary task of fighting the United States' Covid-19 epidemic, providers are turning to AI as a potential tool. Stanford, for example, is evaluating whether AI can help identify Covid-19 patients who are likely to require intensive care. New York University researchers have embarked on a similar effort, and they've found that an AI tool helped to identify three factors that researchers could use to predict whether a patient would develop a severe case of Covid-19 with up to 80% accuracy.
Hospitals also are using AI to help screen patients and frontline medical workers who might be infected with the new coronavirus, to differentiate Covid-19 from other respiratory conditions, to track hospitals supplies and capacity, and to monitor patients outside of the hospital setting.
Some research suggests health care leaders could be right about AI's potential.
For example, a study recently published in Nature found that an AI system developed by Google in some cases can detect breast cancer better than radiologists. As part of the study, researchers asked six radiologists in the United States to look at 500 mammograms and compared their responses to that of the AIand the researchers found the AI system generally outperformed the radiologists in determining whether a woman would develop breast cancer.
Google's had some other early AI successes, as well. For instance, Advisory Board's Jackie Kimmel writes that "one Google-created algorithm was shown by Stanford researchers to diagnose skin cancer as well as a dermatologist, while another algorithm was as effective at diagnosing certain eye diseases as ophthalmologists." According to Kimmel, research showed another Google algorithm was 99% accurate when detecting breast cancer in lymph node biopsies, and a separate study "found Google's lung cancer screening algorithm outperformed all radiologists in the control group at correctly diagnosing the cancerdetecting 5% more true positives and cutting false positives by 11%."
And it's not just Google that's seen success with health care AI. For example, the Associated Press' Matt O'Brien and Christina Larson write that, as 2019 came to an end, the HealthMap AI system at Boston Children's Hospital "sent out the first global alert about a new viral outbreak in China" that has evolved into the current coronavirus pandemic.
But evidence also suggests AI can sometimes fall short.
For instance, while the Nature study on Google's AI system found that the system in some cases was better than radiologists at detecting and predicting breast cancer, it also found that radiologists in some cases outperformed the AI system. All six radiologists in the study at some point caught a cancer case that the AI missed.
And in the case of HealthMap's coronavirus alert, O'Brien and Larson report that New York epidemiologist Marjorie Pollack had begun working on an alert about the virus four hours before HealthMap's notice went out. O'Brien and Larson also note that HealthMap "ranked [its] alert's seriousness as only 3 out of 5," and "[i]t took days for HealthMap researchers to recognize its importance."
Some evidence also suggests AI technologies, if applied incorrectly, could worsen existing health disparities, Dhruv Khullar, a physician and researcher, argues. Khullar in a New York Times opinion piece writes that AI may be trained with narrow, unrepresentative data, as well as "real-world" data that perpetuates real-world biases. In addition, Khullar writes that even if an AI system's underlying data is "ostensibly fair" and "neutral," the technology still "has the potential to worsen disparities if its implementation has disproportionate effects for certain groups."
Further, some health care CEOs say there are barriers that have slowed their efforts to adopt AI. Specifically, health care CEOs in the KPMG survey cited privacy issues and a lack of workforce training as barriers that have stymied their efforts to use AI. And Advisory Board's survey found that health care leaders viewed uncertainty regarding the costs and maturity of AI technologies as key challenges.
And as the Washington Post's Meryl Kornfield writes government regulation of AI could be coming. She notes that federal lawmakers last year introduced legislation that would give the Federal Trade Commission the authority to oversee how AI companies collect and use Americans' personal datathough the legislation hasn't yet advanced.
In the meantime, some states have taken steps to regulate the use of AI, and the White House last month released draft principals intended to guide federal agencies in regulating AI technologies. The Trump administration said the draft principles are intended to balance regulatory decisions regarding the technical and ethical issues related to AI with efforts to invent new AI technologiesand some stakeholders praised the draft principles as a positive step.
Further, Alex Engler, a Rubenstein Fellow in governance studies at the Brookings Institution, writes that although AI might be able to play a significant role in addressing future disease outbreaks, AI's role in addressing the coronavirus pandemic may be limited. He notes that, currently, "AI is only helpful when applied judiciously by subject-matter experts," it "needs tons of prior data with known outcomes," which can be hard to come by with such a new virus.
But the recent investing boom in health care AIpaired with health care leaders' excitement about AI technologies and their current applications to the Covid-19 pandemicsuggest providers will continue integrating AI into their businesses.
Health care leaders are beginning to look beyond workflow efficiencies and toward the role AI can play in patient care. About 90% of health care CEOs in the KPMG survey said they were confident AI will improve patients' experiences, particularly when it comes to diagnostics.
Moving beyond diagnostics, Advisory Board experts note that there's been "rapid development" of AI technologies focused on chronic disease management, which "could be a game changer" for health care systems across the globe. Advisory Board experts also have flagged opportunities for population health leaders to use properly trained AI and deep learning systems to address inequities in care, particularly among people of color.
However, Advisory Board experts caution that providers will need to be smart about how they train and use new AI technologies, especially when it comes to verifying the technologies' accuracy. Particularly, they warn that clinical decision making "is often quite messy and highly dependent on doctor intuitionand understanding this fact is essential to understanding the strengths and limitations of AI."
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Stanford launches an accelerated test of AI to help with Covid-19 care – STAT
Posted: at 1:49 pm
In the heart of Silicon Valley, Stanford clinicians and researchers are exploring whether artificial intelligence could help manage a potential surge of Covid-19 patients and identify patients who will need intensive care before their condition rapidly deteriorates.
The challenge is not to build the algorithm the Stanford team simply picked an off-the-shelf tool already on the market but rather to determine how to carefully integrate it into already-frenzied clinical operations.
The hardest part, the most important part of this work is not the model development. But its the workflow design, the change management, figuring out how do you develop that system the model enables, said Ron Li, a Stanford physician and clinical informaticist leading the effort. Li will present the work on Wednesday at a virtual conference hosted by Stanfords Institute for Human-Centered Artificial Intelligence.
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The effort is primed to be an accelerated test of whether hospitals can smoothly incorporate AI tools into their workflows. That process, typically slow and halting, is being sped up at hospitals all over the world in the face of the coronavirus pandemic.
The machine learning model Lis team is working with analyzes patients data and assigns them a score based on how sick they are and how likely they are to need escalated care. If the algorithm can be validated, Stanford plans to start using it to trigger clinical steps such as prompting a nurse to check in more frequently or order tests that would ultimately help physicians make decisions about a Covid-19 patients care.
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The model known as the Deterioration Index was built and is marketed by Epic, the big electronic health records vendor.Li and his team picked that particular algorithm out of convenience, because its already integrated into their EHR, Li said. Epic trained the model on data from hospitalized patients who did not have Covid-19 a limitation that raises questions about whether it will be generalizable for patients with a novel disease whose data it was never intended to analyze.
Nearly 50 health systems which cover hundreds of hospitals have been using the model to identify hospitalized patients with a wide range of medical conditions who are at the highest risk of deterioration, according to a spokesperson for Epic. The company recently built an update to help hospitals measure how well the model works specifically for Covid-19 patients. The spokesperson said that work showed the model performed well and didnt need to be altered. Some hospitals are already using it with confidence, according to the spokesperson. But others, including Stanford, are now evaluating the model in their own Covid-19 patients.
In the months before the coronavirus pandemic, Li and his team had been working to validate the model on data from Stanfords general population of hospitalized patients. Now, theyve switched their focus to test it on data from dozens of Covid-19 patients that have been hospitalized at Stanford a cohort that, at least for now, may be too small to fully validate the model.
Were essentially waiting as we get more and more Covid patients to see how well this works, Li said. He added that the model does not have to be completely accurate in order to prove useful in the way its being deployed: to help inform high-stakes care decisions, not to automatically trigger them.
As of Tuesday afternoon, Stanfords main hospital was treating 19 confirmed Covid-19 patients, nine of whom were in the intensive care unit; another 22 people were under investigation for possible Covid-19, according to Stanford spokesperson Julie Greicius. The branch of Stanfords health system serving communities east of the San Francisco Bay had five confirmed Covid-19 patients, plus one person under investigation. And Stanfords hospital for children had one confirmed Covid-19 patient, plus seven people under investigation, Greicius said.
Stanfords hospitalization numbers are very fluid. Many people under investigation may turn out to not be infected, and many confirmed Covid-19 patients who have relatively mild symptoms may be quickly cleared for discharge to go home.
The model is meant to be used in patients who are hospitalized, but not yet in the ICU. It analyzes patients data including their vital signs, lab test results, medications, and medical history and spits out a score on a scale from 0 to 100, with a higher number signaling elevated concern that the patients condition is deteriorating.
Already, Li and his team have started to realize that a patients score may be less important than how quickly and dramatically that score changes, he said.
If a patients score is 70, which is pretty high, but its been 70 for the last 24 hours thats actually a less concerning situation than if a patient scores 20 and then jumps up to 80 within 10 hours, he said.
Li and his colleagues are adamant that they will not set a specific score threshold that would automatically trigger a transfer to the ICU or prompt a patient to be intubated. Rather, theyre trying to decide which scores or changes in scores should set off alarm bells that a clinician might need to gather more data or take a closer look at how a patient is doing.
At the end of the day, it will still be the human experts who will make the call regarding whether or not the patient needs to go to the ICU or get intubated except that this will now be augmented by a system that is smarter, more automated, more efficient, Li said.
Using an algorithm in this way has potential to minimize the time that clinicians spend manually reviewing charts, so they can focus on the work that most urgently demands their direct expertise, Li said. That could be especially important if Stanfords hospital sees a flood of Covid-19 patients in the coming weeks. Santa Clara County, where Stanford is located, had confirmed 890 cases of Covid-19 as of Monday afternoon. Its not clear how many of them have needed hospitalization, though San Francisco Bay Area hospitals have not so far faced the crush of Covid-19 patients that New York City hospitals are experiencing.
That could change. And if it does, Li said, the model will have to be integrated into operations in a way that will work if Stanford has several hundred Covid-19 patients in its hospital.
This is part of a yearlong series of articles exploring the use of artificial intelligence in health care that is partly funded by a grant from the Commonwealth Fund.
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A guide to healthy skepticism of artificial intelligence and coronavirus – Brookings Institution
Posted: at 1:49 pm
The COVID-19 outbreak has spurred considerable news coverage about the ways artificial intelligence (AI) can combat the pandemics spread. Unfortunately, much of it has failed to be appropriately skeptical about the claims of AIs value. Like many tools, AI has a role to play, but its effect on the outbreak is probably small. While this may change in the future, technologies like data reporting, telemedicine, and conventional diagnostic tools are currently far more impactful than AI.
Still, various news articles have dramatized the role AI is playing in the pandemic by overstating what tasks it can perform, inflating its effectiveness and scale, neglecting the level of human involvement, and being careless in consideration of related risks. In fact, the COVID-19 AI-hype has been diverse enough to cover the greatest hits of exaggerated claims around AI. And so, framed around examples from the COVID-19 outbreak, here are eight considerations for a skeptics approach to AI claims.
No matter what the topic, AI is only helpful when applied judiciously by subject-matter expertspeople with long-standing experience with the problem that they are trying to solve. Despite all the talk of algorithms and big data, deciding what to predict and how to frame those predictions is frequently the most challenging aspect of applying AI. Effectively predicting a badly defined problem is worse than doing nothing at all. Likewise, it always requires subject matter expertise to know if models will continue to work in the future, be accurate on different populations, and enable meaningful interventions.
In the case of predicting the spread of COVID-19, look to the epidemiologists, who have been using statistical models to examine pandemics for a long time. Simple mathematical models of smallpox mortality date all the way back to 1766, and modern mathematical epidemiology started in the early 1900s. The field has developed extensive knowledge of its particular problems, such as how to consider community factors in the rate of disease transmission, that most computer scientists, statisticians, and machine learning engineers will not have.
There is no value in AI without subject-matter expertise.
It is certainly the case that some of the epidemiological models employ AI. However, this should not be confused for AI predicting the spread of COVID-19 on its own. In contrast to AI models that only learn patterns from historical data, epidemiologists are building statistical models that explicitly incorporate a century of scientific discovery. These approaches are very, very different. Journalists that breathlessly cover the AI that predicted coronavirus and the quants on Twitter creating their first-ever models of pandemics should take heed: There is no value in AI without subject-matter expertise.
The set of algorithms that conquered Go, a strategy board game, and Jeopardy! have accomplishing impressive feats, but they are still just (very complex) pattern recognition. To learn how to do anything, AI needs tons of prior data with known outcomes. For instance, this might be the database of historical Jeopardy! questions, as well as the correct answers. Alternatively, a comprehensive computational simulation can be used to train the model, as is the case for Go and chess. Without one of these two approaches, AI cannot do much of anything. This explains why AI alone cant predict the spread of new pandemics: There is no database of prior COVID-19 outbreaks (as there is for the flu).
So, in taking a skeptics approach to AI, it is critical to consider whether a company spent the time and money to build an extensive dataset to effectively learn the task in question. Sadly, not everyone is taking the skeptical path. VentureBeat has regurgitated claims from Baidu that AI can be used with infrared thermal imaging to see the fever that is a symptom of COVID-19. Athena Security, which sells video analysis software, has also claimed it adapted its AI system to detect fever from thermal imagery data. Vice, Fast Company, and Forbes rewarded the companys claims, which included a fake software demonstration, with free press.
To even attempt this, companies would need to collect extensive thermal imaging data from people while simultaneously taking their temperature with a conventional thermometer. In addition to attaining a sample diverse in age, gender, size, and other factors, this would also require that many of these people actually have feversthe outcome they are trying to predict. It stretches credibility that, amid a global pandemic, companies are collecting data from significant populations of fevered persons. While there are other potential ways to attain pre-existing datasets, questioning the data sources is always a meaningful way to assess the viability of an AI system.
The company Alibaba claims it can use AI on CT imagery to diagnose COVID-19, and now Bloomberg is reporting that the company is offering this diagnostic software to European countries for free. There is some appeal to the idea. Currently, COVID-19 diagnosis is done through a process called polymerase chain reaction (PCR), which requires specialized equipment. Including shipping time, it can easily take several days, whereas Alibaba says its model is much faster and is 96% accurate.
However, it is not clear that this accuracy number is trustworthy. A poorly kept secret of AI practitioners is that 96% accuracy is suspiciously high for any machine learning problem. If not carefully managed, an AI algorithm will go to extraordinary lengths to find patterns in data that are associated with the outcome it is trying to predict. However, these patterns may be totally nonsensical and only appear to work during development. In fact, an inflated accuracy number can actually be an important sign that an AI model is not going to be effective out in the world. That Alibaba claims its model works that well without caveat or self-criticism is suspicious on its face.
[A]n inflated accuracy number can actually be an important sign that an AI model is not going to be effective out in the world.
In addition, accuracy alone does not indicate enough to evaluate the quality of predictions. Imagine if 90% of the people in the training data were healthy, and the remaining 10% had COVID-19. If the model was correctly predicting all of the healthy people, a 96% accuracy could still be truebut the model would still be missing 40% of the infected people. This is why its important to also know the models sensitivity, which is the percent of correct predictions for individuals who have COVID-19 (rather than for everyone). This is especially important when one type of mistaken prediction is worse than the other, which is the case now. It is far worse to mistakenly suggest that a person with COVID-19 is not sick (which might allow them to continue infecting others) than it is to suggest a healthy person has COVID-19.
Broadly, this is a task that seems like it could be done by AI, and it might be. Emerging research suggests that there is promise in this approach, but the debate is unsettled. For now, the American College of Radiology says that the findings on chest imaging in COVID-19 are not specific, and overlap with other infections, and that it should not be used as a first-line test to diagnose COVID-19. Until stronger evidence is presented and AI models are externally validated, medical providers should not consider changing their diagnostic workflowsespecially not during a pandemic.
The circumstances in which an AI system is deployed can also have huge implications for how valuable it really is. When AI models leave development and start making real-world predictions, they nearly always degrade in performance. In evaluating CT scans, a model that can differentiate between healthy people and those with COVID-19 might start to fail when it encounters patients who are sick with the regular flu (and it is still flu season in the United States, after all). A drop of 10% accuracy or more during deployment would not be unusual.
In a recent paper about the diagnosis of malignant moles with AI, researchers noticed that their models had learned that rulers were frequently present in images of moles known to be malignant. So, of course, the model learned that images without rulers were more likely to be benign. This is a learning pattern that leads to the appearance of high accuracy during model development, but it causes a steep drop in performance during the actual application in a health-care setting. This is why independent validation is absolutely essential before using new and high-impact AI systems.
When AI models leave development and start making real-world predictions, they nearly always degrade in performance.
This should engender even more skepticism of claims that AI can be used to measure body temperature. Even if a company did invest in creating this dataset, as previously discussed, reality is far more complicated than a lab. While measuring core temperature from thermal body measurements is imperfect even in lab conditions, environmental factors make the problem much harder. The approach requires an infrared camera to get a clear and precise view of the inner face, and it is affected by humidity and the ambient temperature of the target. While it is becoming more effective, the Centers for Disease Control and Prevention still maintain that thermal imaging cannot be used on its owna second confirmatory test with an accurate thermometer is required.
In high-stakes applications of AI, it typically requires a prediction that isnt just accurate, but also one that meaningfully enables an intervention by a human. This means sufficient trust in the AI system is necessary to take action, which could mean prioritizing health-care based on the CT scans or allocating emergency funding to areas where modeling shows COVID-19 spread.
With thermal imaging for fever-detection, an intervention might imply using these systems to block entry into airports, supermarkets, pharmacies, and public spaces. But evidence shows that as many as 90% of people flagged by thermal imaging can be false positives. In an environment where febrile people know that they are supposed to stay home, this ratio could be much higher. So, while preventing people with fever (and potentially COVID-19) from enabling community transmission is a meaningful goal, there must be a willingness to establish checkpoints and a confirmatory test, or risk constraining significant chunks of the population.
This should be a constant consideration for implementing AI systems, especially those used in governance. For instance, the AI fraud-detection systems used by the IRS and the Centers for Medicare and Medicaid Services do not determine wrongdoing on their own; rather, they prioritize returns and claims for auditing by investigators. Similarly, the celebrated AI model that identifies Chicago homes with lead paint does not itself make the final call, but instead flags the residence for lead paint inspectors.
Wired ran a piece in January titled An AI Epidemiologist Sent the First Warnings of the Wuhan Virus about a warning issued on Dec. 31 by infectious disease surveillance company, BlueDot. One blog post even said the company predicted the outbreak before it happened. However, this isnt really true. There is reporting that suggests Chinese officials knew about the coronavirus from lab testing as early as Dec. 26. Further, doctors in Wuhan were spreading concerns online (despite Chinese government censorship) and the Program for Monitoring Emerging Diseases, run by human volunteers, put out a notification on Dec. 30.
That said, the approach taken by BlueDot and similar endeavors like HealthMap at Boston Childrens Hospital arent unreasonable. Both teams are a mix of data scientists and epidemiologists, and they look across health-care analyses and news articles around the world and in many languages in order to find potential new infectious disease outbreaks. This is a plausible use case for machine learning and natural language processing and is a useful tool to assist human observers. So, the hype, in this case, doesnt come from skepticism about the feasibility of the application, but rather the specific type of value it brings.
AI is unlikely to build the contextual understanding to distinguish between a new but manageable outbreak and an emerging pandemic of global proportions.
Even as these systems improve, AI is unlikely to build the contextual understanding to distinguish between a new but manageable outbreak and an emerging pandemic of global proportions. AI can hardly be blamed. Predicting rare events is just very hard, and AIs reliance on historical data does it no favors here. However, AI does offer quite a bit of value at the opposite end of the spectrumproviding minute detail.
For example, just last week, California Gov. Gavin Newsom explicitly praised BlueDots work to model the spread of the coronavirus to specific zip codes, incorporating flight-pattern data. This enables relatively precise provisioning of funding, supplies, and medical staff based on the level of exposure in each zip code. This reveals one of the great strengths of AI: its ability to quickly make individualized predictions when it would be much harder to do so individually. Of course, individualized predictions require individualized data, which can lead to unintended consequences.
AI implementations tend to have troubling second-order consequences outside of their exact purview. For instance, consolidation of market power, insecure data accumulation, and surveillance concerns are very common byproducts of AI use. In the case of AI for fighting COVID-19, the surveillance issues are pervasive. In South Korea, the neighbors of confirmed COVID-19 patients were given details of that persons travel and commute history. Taiwan, which in many ways had a proactive response to the coronavirus, used cell phone data to monitor individuals who had been assigned to stay in their homes. Israel and Italy are moving in the same direction. Of exceptional concern is the deployed social control technology in China, which nebulously uses AI to individually approve or deny access to public space.
Government action that curtails civil liberties during an emergency (and likely afterwards) is only part of the problem. The incentives that markets create can also lead to long-term undermining of privacy. At this moment, Clearview AI and Palantir are among the companies pitching mass-scale surveillance tools to the federal government. This is the same Clearview AI that scraped the web to make an enormous (and unethical) database of facesand it was doing so as a reaction to an existing demand in police departments for identifying suspects with AI-driven facial recognition. If governments and companies continue to signal that they would use invasive systems, ambitious and unscrupulous start-ups will find inventive new ways to collect more data than ever before to meet that demand.
In new approaches to using AI in high-stakes circumstances, bias should be a serious concern. Bias in AI models results in skewed estimates across different subgroups, such as women, racial minorities, or people with disabilities. In turn, this frequently leads to discriminatory outcomes, as AI models are often seen as objective and neutral.
While investigative reporting and scientific research has raised awareness about many instances of AI bias, it is important to realize that AI bias is more systemic than anecdotal. An informed AI skeptic should hold the default assumption that AI models are biased, unless proven otherwise.
An informed AI skeptic should hold the default assumption that AI models are biased, unless proven otherwise.
For example, a preprint paper suggests it is possible to use biomarkers to predict mortality risk of Wuhan COVID-19 patients. This might then be used to prioritize care for those most at riska noble goal. However, there are myriad sources of potential bias in this type of prediction. Biological associations between race, gender, age, and these biomarkers could lead to biased estimates that dont represent mortality risk. Unmeasured behavioral characteristics can lead to biases, too. It is reasonable to suspect that smoking history, more common among Chinese men and a risk factor for death by COVID-19, could bias the model into broadly overestimating male risk of death.
Especially for models involving humans, there are so many potential sources of bias that they cannot be dismissed without investigation. If an AI model has no documented and evaluated biases, it should increase a skeptics certainty that they remain hidden, unresolved, and pernicious.
While this article takes a deliberately skeptical perspective, the future impact of AI on many of these applications is bright. For instance, while diagnosis of COVID-19 with CT scans is of questionable value right now, the impact that AI is having on medical imaging is substantial. Emerging applications can evaluate the malignancy of tissue abnormalities, study skeletal structures, and reduce the need for invasive biopsies.
Other applications show great promise, though it is too soon to tell if they will meaningfully impact this pandemic. For instance, AI-designed drugs are just now starting human trials. The use of AI to summarize thousands of research papers may also quicken medical discoveries relevant to COVID-19.
AI is a widely applicable technology, but its advantages need to be hedged in a realistic understanding of its limitations. To that end, the goal of this paper is not to broadly disparage the contributions that AI can make, but instead to encourage a critical and discerning eye for the specific circumstances in which AI can be meaningful.
The Brookings Institution is a nonprofit organization devoted to independent research and policy solutions. Its mission is to conduct high-quality, independent research and, based on that research, to provide innovative, practical recommendations for policymakers and the public. The conclusions and recommendations of any Brookings publication are solely those of its author(s), and do not reflect the views of the Institution, its management, or its other scholars.
Microsoft provides support to The Brookings InstitutionsArtificial Intelligence and Emerging Technology (AIET) Initiative. The findings, interpretations, and conclusions in this report are not influenced by any donation. Brookings recognizes that the value it provides is in its absolute commitment to quality, independence, and impact. Activities supported by its donors reflect this commitment.
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A guide to healthy skepticism of artificial intelligence and coronavirus - Brookings Institution
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Blackbird.AI CEO: COVID-19 is the Olympics of disinformation – VentureBeat
Posted: at 1:49 pm
COVID-19 disinformation has exploded in recent weeks, with campaigns using a combination of bots and humans to sow fear and confusion at a time when verifiable information has become a matter of life or death.
According to a new report from Blackbird.AI, a wide range of actors are leveraging confusion around the coronavirus to dupe people into amplifying false and misleading information. With COVID-19s almost unprecedented impact around the globe, virtually every type of player in the disinformation wars, from nations to private actors, is rushing into the breach.
If its favorable for creating societal chaos, for sowing some sort of discord, then they all kind of jump on, said Blackbird.AI CEO Wasim Khaled. COVID-19 is the Olympics of disinformation. Every predator is in for this event.
In the past few weeks, many of the leading online platforms have attempted to clamp down on the information warfare their services have enabled. To direct users toward helpful sites, many of them now place links to reputable scientific or government sources at the top of feeds or in search results.
And theyve implemented other tactics in an attempt to turn the tide. Pinterest has been highlighting verified health advice, while Facebook gave unlimited free advertising to the World Health Organization. Meanwhile, Google has announced it will invest $6.5 million to fight misinformation.
Still, voice assistants like Alexa and Google Assistant are struggling to respond to questions about COVID-19. To address the onslaught of erroneous information online, the U.K. has established a disinformation rapid response team. Today, an EU official blasted players like Google, Facebook, and Amazon for continuing to make money from fake news and disinformation.
We still see that the major platforms continue to monetize and incentivize disinformation and harmful content about the pandemic by hosting online ads, the European Unions justice chief Vera Jourova told Reuters. This should be stopped. The financial disincentives from clickbait disinformation and profiteering scams also should be stopped.
Founded in 2014, Blackbird.AI has developed a platform that uses artificial intelligence to sift through massive amounts of content to dissect disinformation events. It uses a combination of machine learning and human specialists to identify and categorize the types of information flowing across social media and news sites. In doing so, Blackbird. AI can separate information being created by bots from human-generated content and track how its being amplified.
Typically, the company works with corporations and brands to monitor changes to their reputation. But with the rise of the COVID-19 pandemic, the company has shifted to focus on a new threat. The goal is to raise companies and individuals awareness in the hopes that they can curb the virality of disinformation campaigns.
Anyone whos watching this spread is pretty familiar with the concept of flattening the curve, Khaled said. Weve always used a similar concept. Weve described disinformation as a contagion, with virality being the driver.
Unfortunately, the spread of disinformation is still in the exponential part of the curve.
For its COVID-19 Disinformation Report, the company analyzed 49,755,722 tweets from 13,203,289 unique users on COVID-19 topics between February 27 and March 12. The number of tweets in this category soared as Italy implemented lockdowns and the Dow Jones plummeted. Of those tweets, the company found that 18,880,396 were inorganic, meaning from a source that wasnt a real person.
Measuring the ratio of inorganic content helps the company generate a Blackbird Manipulation Index. In this case, the BBMI of COVID-19 tweets is 37.95%, which places it just inside the medium level of manipulation.
Were facing this kind of asymmetrical information warfare thats being waged against not only the American public but across many societies in the world at a really incredible clip at one of our most vulnerable moments in history, he said. There is incredible fear and uncertainty around what is right and what is wrong. And today people feel if you do the wrong thing, you just might kill your grandfather. Its a lot of pressure and so people are looking for information. That gives a huge opening to disinformation actors.
That BBMI number varies widely within specific campaigns.
For instance, on February 28 President Trump held a rally in Charleston, South Carolina, where he claimed the concern around coronavirus was an attempt by Democrats to discredit him, calling it their new hoax. Following that speech, Blackbird.AI detected a spike in hashtags such as #hoax, #Democrats, #DemHoax, #FakeNews, #TrumpRallyCharleston and #MAGA. A similar spike occurred after March 9, when Italian politicians quarantined the whole country.
In both cases, the platform detected a coordinated campaign to discredit the Democratic Party, a narrative dubbed Dem Panic. Of 2,535,059 tweets, 839,764 were inorganic for a BBMI of 33.1%.
But within that campaign, certain hashtag subcategories showed even higher levels of manipulation: #QAnon (63.38% BBMI), #MAGA (57.00%), and #Pelosi (53.17%).
The driving message: that the Democrats were overblowing the issue in order to hurt President Trump, the report says. The Dem Panic narrative and related spin-offs also included the widespread mention of the out of control homeless population and high number of immigrants in Democratic districts. Many of these messages unwittingly found their way into what would traditionally be considered credible media stories.
In all these cases, the hashtags have synthetic origins but eventually spread far enough that real people picked them up and furthered their reach. The broad goal of such campaigns, said Khaled, is to delegitimize politicians, the media, medical experts, and scientists by spreading disinformation.
While all the policymakers are still trying to decide what is the best course of action, these campaigns work very hard at undermining that type of advice, he said. The goal was, How do we downplay the health risks of COVID-19 to the American public and to cast doubt on the warnings that are given by the government and public health agencies?'
Other coronavirus disinformation campaigns include the conspiracy theory suggesting the U.S. had bioengineered the virus and introduced it into China.
This content was seeded into public media in China, Khaled said. And, of course, it was immediately distributed by social media users who believed those narratives and amplified them. Its happened around the world and in dozens of languages. There was not only the U.S. and China, but there was Iran blaming the U.S., the U.S. blaming China, all of these campaigns were out there.
While Blackbird.AI doesnt necessarily identify the originators of these campaigns, Khaled said they generally fall into three categories. The first is state-backed, typically Russia or China these days. The second is disinformation-as-a-service, where people can hire firms to buy disinformation service packages. The third is the lone wolf that just wants to watch the world burn.
It all has the objective of creating a shifting in perceptions in the readers mind pushing them toward a behavior change or pushing them to spread the narrative further, he said.
This doesnt mean just retweeting fake news. Behavioral manipulation can also be used to move fake masks or drugs. And in some extreme circumstances, it has resulted in direct threats to life. Khaled noted that Dr. Anthony Fauci, the infectious disease specialist who is featured at presidential briefings, required extra security following death threats that were fueled by online conspiracy theorists. In addition, a train engineer attempted to attack the Navy ship entering a Los Angeles harbor by derailing a train because he believed another set of online conspiracies about the ship being part of a government takeover.
While Blackbird.AI is trying to help rein in the chaos, Khaled is not optimistic that the campaigns are going to be contained anytime soon.
Im 100% confident this is going to get much worse on the disinformation cycle, he said. Not only are we not seeing any indication that its slowing down, were seeing significant indication that its significantly ramping up. These disinformation actors, theyre going to take every possible advantage right now. People have to be aware. They have to understand that the things that they are going to see might have bad intent behind [them], they have to go to the CDC, they have to go to the WHO, they cannot take the stuff that they see at face value.
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Blackbird.AI CEO: COVID-19 is the Olympics of disinformation - VentureBeat
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