Monthly Archives: April 2020

Tolkien was right: giant trees have towering role in protecting forests – The Guardian

Posted: April 9, 2020 at 5:47 pm

Scientists have shown to be true what JRR Tolkien only imagined in the Lord of the Rings: giant, slow-reproducing trees play an outsized role in the growth and health of old forests.

In the 1930s, the writer gave his towering trees the name Ents. Today, a paper in the journal Science says these long-lived pioneers contribute more than previously believed to carbon sequestration and biomass increase.

The authors said their study highlights the importance of forest protection and biodiversity as a strategy to ease global heating. They say it should also encourage global climate modellers to shift away from representing all the trees in a forest as essentially the same.

This analysis shows that that is not good enough for tropical forests and provides a way forward, said Caroline Farrior, an assistant professor of integrative biology at the University of Texas at Austin. We show that the variation in tropical forest species growth, survival and reproduction is important for predicting forest carbon storage.

Long-lived pioneers a term that has been around for decades include species such as mahogany, Brazil nut trees and Ceiba pentandra, which are visible far above the rest of the canopy because they grow fast (at up to twice the speed of plants lower in the canopy) for hundreds of years.

Researchers believe this is the result of a trade-off between stature and reproduction: they are able to put more energy into putting on biomass than into producing offspring.

The study is based on more than 30 years of data collected from old growth and secondary rainforest on Barro Colorado, an island in the middle of the Panama Canal.

The scientists grouped the 282 different species of tree into five categories determined by growth, reproduction and longevity. This showed the relative roles of fast species that grow and die quickly, slow species that grow slowly and reach an old age, infertile giants that live long and reproduce over a long time, and fertile dwarfs and small shrubs and low treelets that grow slowly, die young, but produce a large number of offspring.

By simulating different combinations of these groups, the scientists were able to build a model that reproduced the dynamics of the recovery of nearby young forests.

This knowledge of how quickly trees grow, how long they live and how many offspring they produce could help in the restoration of tropical forests, which are currently being cut down at an alarming rate. It could also dispel a theory that such giant trees disappear once a forest reaches maturity.

Our results show long-lived pioneers are not transient but an important feature in old forests. They represent about 40% of the biomass and there are no signs that this declines over time, said the papers lead author, Nadja Rger of the German Centre for Integrative Biodiversity Research and the University of Leipzig. However, she cautioned that others forest showed different patterns.

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No One Retires Anymore – TownandCountrymag.com

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Andersen Ross Photography Inc

People once yearned for retirement. They would hope to quit at 65, get a gold watcha dubious gift for someone who no longer has a scheduleand move someplace warm to play golf and eat dinner at an increasingly early hour. During the first tech bubble, young entrepreneurs cashed out and retired before 40, drifting off into travel, philanthropy, and the occasional vanity project. Everyone planned to retire. The contest was who could do it earliest.

Today, a tumbling stock market might have upset the plans of the millennials of the FIRE (financial independence, retire early) movement. But the secret weapon for some of the world's most successful people is that retirement was never an option.

When Jayson Adams retired in 1997 at 29, after selling his company Netcode to Netscape for more money than he would ever need, his plan was to spend the rest of his years surfing and playing guitar. When I ran into him a few months back, it was at the Google offices in Santa Monica. Where he was working.

Gary Hershorn

No one chooses to retire anymore if they can help it. Warren Buffett, whose personal net worth is more than $90 billion, is 89 and still working. Henry Kissinger, 96, runs a consulting firm that advises world leaders by drawing on his extensive knowledge of human history, most of which he has lived through. Elaine May, 87, could rest on her beloved-comic laurels but is instead gearing up to direct her first feature film in 32 years. New York Post gossip columnist Cindy Adams, 89, will surely call her when it comes out. Sheldon Adelson, 86, not only runs the Venetian hotels, he also advises our President Trump, who is 73.

This coming November that president is likely to run against a 77-year-old Joe Biden or a 78-year-old Bernie Sanders. Rupert Murdoch, who packages all of this as blood sport, is 88. Robert Caro, 84, is rushing to finish his Lyndon Johnson biography before his own biographer gets to work, and Netflix recently scooped up the rights to a movie starring 85-year-old Sophia Loren. When I had lunch with Carl Reiner, 98, at his house not long ago, he brought me upstairs to a room where he toiled with two employees on several books he was writing.

Graydon Carter, 70, left Vanity Fair in 2017 and started spending part of the year in Provence, but he didnt take up petanque, he started the new weekly publication Air Mail. His advice? First of all, never, ever, actually retireat least not in the not-working, checkered golf pants, Republican-voting, dinner at 5 p.m. sense of the word. Cut back on your workthats a must. And leave plenty of time for reading and mulling a final chapter. When Miuccia Prada, 70, recently announced that Raf Simons was to be her cocreative director, she was adamant that it wasnt a prelude to retirement. Oh no, she said, to do better, to work harderIm very interested in this.

Never, ever, actually retire. Cut back on your workthats a must. And leave plenty of time for reading and mulling a final chapter. Graydon Carter

All of these people have enough money to retire. Which is, oddly, the norm for people who keep working past 70. While the age at which Americans intend to retire has indeed gone up by six years over the last two and a half decades, to 66, according to Gallup polls, most of that change comes among college graduates. Four decades ago people with a BA retired six months later than people who had only a high school diploma. Now theres a three-year disparity.

Retirement has become so uncool that more than a third of the members of AARP are still working. Which is why the lobbying group officially changed its name in 1999 from the American Association of Retired Persons to an acronym that doesnt stand for anything. In fact, when AARP CEO Jo Ann Jenkins was asked by the Washington Post for her advice about retirement, she said, My first piece of advice is: Dont retire.

Its as if the NRA declared that hunting knives are where its at.

Thats because work isnt merely what successful people do, its who they are. If you ask most people how theyre doing, theyll say fine, but if you ask a member of the cosmopolitan elite, shell say busy. In our brief moments of not working, we are listening to audiobooks while getting our steps in. We dont sit by a pool. We dont play card games. We dont golf. We crush it.

I cannot imagine ever chilling under a mango tree. I get much more joy from my work than from cruising in the South of France, says Arianna Huffington, who is 69 and started a new company, Thrive Global, four years ago. But others may get more fulfillment from cruising or golfing. And there is absolutely nothing wrong with that. Except, of course, that they are losers who are never getting invited to Davos.

Age 89

Warren BuffetOCCUPATION: Omahas oracle is at Berkshire Hathaway dailyand has chicken nuggets for l.

Age 70

Miuccia PradaOCCUPATION: The designer recently took on partner Raf Simons, but not to lighten her workload. Instead, she said, it was to work harder.

Age 98

Carl ReinerOCCUPATION: Comedian, director, and Twitter must-follow Reiner isnt resting on his laurelshes busy writing books.

Age 89

Cindy AdamsOCCUPATION: New Yorks gossip queen not only writes a column four times a week, shes about to be the subject of a Showtime series.

Age 77

Judith SheindlinOCCUPATION: Sheindlin is wrapping up Judge Judy after 25 years, but she isnt ditching her robes. She plans to launch a new series in 2021.

Age 96

Henry KissingerOCCUPATION: The elder statesman of American diplomacy is still active in foreign policy circles and on the New York City society circuit.

Age 85

Sophia LorenOCCUPATION: The 1960 hit Two Women was Lorens breakthrough. This year Netflix will air her latest, The Life Ahead, directed by her son.

Huffington points out that the word retire means to withdraw or retreat. Not only dont the elite retreat, they have nothing to retreat into. Even if theyre wrong, people dont feel as though they have time in life to have avocations, says Laura L. Carstensen, director of Stanford Universitys Center of Longevity. Theres a big drop in how much time we spend with our neighbors. Were less socially engaged in our communities. So people think, What would I do? Because theyve done nothing else for 40 years.

The transition is so tough that the Harvard School of Public Health found that retirees are 40 percent more likely to have a heart attack or stroke during the first year of retirement than people who keep working.

Cavan Images

When 27-year-old Alfonso Cobo sold Unfold, the social media template tool he co-founded, to Squarespace at the end of last year for enough money to last at least a lifetime, he didnt consider so much as a weekend at the beach. Id honestly do it for fun, Cobo says about his job. He swears hell never retire. Id rather work than go clubbing.

Sterling McDavid, a 31-year-old former Goldman Sachs analyst who co-founded the fashion line Burnett New York, tells her employees that shell never retire. It honestly gives me total anxiety, she says. Sitting on the beach with my pia colada? I can barely do that on vacation. Retiring at 65 and thinking I had to do that for 30 years? I cant imagine.

Her dad, David McDavid, a 78-year-old former co-owner of the Dallas Mavericks, retired young. For a month. Then he started a new business. Sterling says that both she and her dad learned a lesson during that time. You have only one life, she says, and shes going to spend as much of it as she can working.

NBC

The privileged members of society have never embraced being idle; knowledge economy workers disgust at idleness is the same thing that every aristocracy has felt. Landed gentry didnt technically work, because paid work was awful: hoeing, manuring, smithing. But they did spend their time productively, doing things that are jobs today. They were naturalists, geographers, historians, writers, artists, harpsichordists, and, from what I remember from The Cherry Orchard, billiard players. To cease to contribute was to concede that you werent important. It meant you werent busy.

I do have one friend who retired at 40 eight years ago and has kept to it. Ive heard about these people who cant seem to walk away from work, fearing irrelevance and boredom, he says. Fortunately, Im not one of them. I guess my career was just a small facet of my identity.

My friend is a throwback to his parents generation. Carstensen points out that the retirement age dropped unnaturally in the second half of the 20th century, back when Goldman partners famously got out young. People kept retiring earlier and earlier. There was a culture of boasting about retiring early, Carstensen says. That has really changed. Some of it is discovering that you can play only so many rounds of golf in a week for so many years without realizing youre bored.

kafl

The most successful non-retirer of all time may be Norman Lear. Last fall, Lear, 97, reupped his first-look deal at Sony for another three years. Hes got a show on Pop TV (One Day at a Time), he won an Emmy last year for Live in Front of a Studio Audience (which ABC renewed for two more specials), and he has several other projects in development. If retirement were a game, it would be one that Lear was never asked to play.

I cant imagine not having a place like this to come to with people I care about to talk about things that interest me, Lear says from his office on the Sony lot. He thinks so little about retirement that a sitcom pilot he created was called Guess Who Died?.

The fallout from this trend could be a more difficult job market. While the likes of Elon Musk and Andrew Yang worry that robots will take our jobs, they will much more likely be taken by dotards who refuse to retire. To keep the unemployment rate from skyrocketing, Stanfords Carstensen advocates that people of every age work fewer, more flexible hours. I could see us going to 30-hour or even 25-hour workweeks without this idea that were going to retire for 25 years, she says.

Carstensen knows firsthand how tight the job market could be if we dont do this, but shes not going anywhere. Shes 66, and shes tenured.

This story appears in the May 2020 issue of Town & Country.

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Brand Marketing Through the Coronavirus Crisis – Harvard Business Review

Posted: at 5:47 pm

Executive Summary

The coronavirus crisis has led to new consumer behaviors and sentiments. The author recommends five ways for brands to serve and grow their customers, mitigate risk, and take care of their people during this difficult time: 1) Present with empathy and transparency; 2) Use media in more agile ways; 3) Associate your brand with good; 4) Track trends and build scenarios; 5) Adapt to new ways of working to keep delivering.

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In times of crisis, it may be hard for marketers to know where to begin. In just a few short weeks, people have shifted into protection mode, focused on themselves, their families, their employees, their customers, and their communities. Social media reflects this, with pleas for fellow citizens to follow government safety guidelines. People have crossed partisan lines to build bridges within their neighborhoods and communities and unify against an invisible force.

With social distancing keeping many people at home, were also seeing major shifts in behavioral trends. Consumers have returned to broadcast and cable television and other premium media sources for credible information. They are also seeking more in the way of escapism and entertainment downloading gaming apps, spending even more time on social media, and streaming more movies and scripted programming. And between remote working arrangements and live-streamed workout classes, college lectures, and social engagements, we are testing the bandwidth of our homes in a largely pre-5G world.

Meanwhile, the need for physical goods is placing pressure on new channels, with demand for e-commerce rising to new levels. For those who do venture out, grocery and convenience stores are the source for essentials, but supply is inconsistent. Health and safety concerns are driving more customers toward frictionless payment systems, such as using mobile phones to pay at check-out without touching a surface or stylus.

Some of these behavior changes may be temporary, but many may be more permanent. As people move beyond the current mode of survival, the momentum behind digital-experience adoption is unlikely to reverse as people are forced by circumstances to try new things. With so much changing so fast during this difficult time, what actions can brands take to serve and grow their customer base, mitigate risk, and take care of their people ?

People feel vulnerable right now. Empathy is critical. Many banks, for example, have moved to waive overdraft fees, recognizing the hardship on their customers. SAP has made its Qualtrics Remote Work Pulse platform free to companies who might be rapidly transitioning to new ways of working. Such instances show humility in the face of a force larger than all of us.

The nuances of brand voice are more delicate than ever. Brands that use this time to be commercially exploitative will not fare well. Better to do as Guinness did in the period surrounding St. Patricks Day, when the company shifted its focus away from celebrations and pub gatherings and instead leaned into a message of longevity and wellbeing. In these moments, we dont have all the answers, and we need to acknowledge that. If you make pledges, even during uncertain times, you have to be able to deliver on what you say.

To quickly pivot creative messages as circumstances change, marketers will want to build more rapid-response operating models internally and with agencies. Access to remote production and creative capacity will become particularly important as the crisis evolves. Nike, for example, immediately moved to adopt a new message: Play inside, play for the world. And in order to promote social distancing and show a commitment to public safety, Chiquita Brands removed Miss Chiquita from their logo. Im already home. Please do the same and protect yourself, its Instagram caption read.

Beyond creative, as the mix of actual media platforms used by consumers changes quickly, marketers should consider modifying their media mix. For example, with digital entertainment spiking, marketers may want to amplify their use of ad-supported premium video streaming and mobile gaming. Similarly, as news consumption peaks while consumers jostle to stay informed, brands should not fear that adjacency, given the level of engagement and relevance. News may simply be an environment that requires more careful monitoring of how frequently ads appear to avoid creative being over-exposed, which can damage brand equity.

People will remember brands for their acts of good in a time of crisis, particularly if done with true heart and generosity. This could take the form of donating to food banks, providing free products for medical personnel, or continuing to pay employees while the companys doors are closed. Adobe, for example, immediately made Creative Cloud available to K-12 institutions, knowing this was a moment to give rather than be purely commercial. Consumers will likely remember how Ford, GE, and 3M partnered to repurpose manufacturing capacity and put people back to work to make respirators and ventilators to fight coronavirus. And people appreciate that many adult beverage companies, from Diageo to AB InBev, repurposed their alcohol-manufacturing capabilities to make hand sanitizer, alleviating short supplies with their Its in our hands to make a difference message.

Feel-good content that alleviates anxiety and promotes positive messaging will go a long way to enhancing the brand. However, companies need to show that their contributions are material and not solely for commercial benefit. Consumers recognize authenticity and true purpose.

Frequent tracking of human behavioral trends will help marketers gain better insights in real time. Marketers will want to measure sentiment and consumption trends on a regular basis to better adapt messaging, closely observing the conversation across social-media platforms, community sites, and e-commerce product pages to look for opportunities and identify looming crises more quickly. Companies should consider quickly building dashboards with this kind of data to fuel the right decisions.

Marketers will also want to consider building deeper connections with their C-suite colleagues to provide insights to executives who, increasingly, will be involved with marketing choices. The marketing team should work closely with finance and operations to forecast different scenarios and potential outcomes, depending on how long the crisis lasts.

Its encouraging how quickly many companies were able to transition to remote working arrangements. Deploying collaboration technologies can seamlessly provide chat, file sharing, meeting and call capabilities, enabling teams to stay connected and remain productive. Already, virtual happy hours are emerging as the new normal to build team morale. Partners are pitching remotely, recognizing that an in-face sales call is unlikely to transpire for weeks to come. Leaders have to do their best to transition each element of the operating modelfrom marketing, to sales, to serviceto this new normal. New sources of innovation and even margin improvement will emerge out of our current discomfort.

We are in the acknowledge-and-adapt phase of the Covid-19 pandemic. But we also have to plan for lifebeyond the crisis. As we navigate what we know, marketing leaders must work externally to keep their brands and customer journeys as whole as possible, while working internally to do three things:

Unquestionably, there is a forced acceleration of the digital transformation agenda as we recognize how quickly customers and employees have embraced digitally enabled journeys and experiences.

Brands are all having to think, operate, and lead in new ways during these uncertain and unprecedented circumstances, and we will all have to learn together with both confidence and humility.

The views reflected in this article are the views of the authors and dont necessarily reflect the views of the global EY organization or its member firms.

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What Is Wrong with My Nose: From Gogol and Freud to Goldin+Senneby (via Haraway) – Journal #108 April 2020 – E-Flux

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I once had a boyfriend with a very sensitive nose. It wasnt that his sense of smell was particularly extraordinary; on the contrary, it was rather bad. It was that his nose could hardly be touched without him emitting a suffering ouch! and immediately protecting his organ from further violation. Needless to say, I often happened to be the involuntary cause of this pain, and of his exclamation no, no, not my nose!

I often remembered this ex-boyfriends nose when I started to have issues with my own nose in the summer of 2016, although my symptoms were different. I also thought often of Nikolai Gogols famous short story The Nose, as well as Sigmund Freuds psychoanalytical conclusions about the naso-genital relationship, the fetishistic allure of the noses shine and phallic character. The latter was developed by Freuds close friend Wilhelm Fliess whounfortunately, and almost fatallyconvinced Freud of its relevance. All if this came back to me last year, when I curated Insurgency of Life, a retrospective exhibition of Goldin+Sennebys work.

As for my nose, it has demanded special attention since I was a child. Being prone to allergies, I blow my nose often, and use nose spray regularly. In 2016, the issues began in May with a simple cold caught on a trip to Singapore, which settled firmly in my snout. Week after week, this fairly prominent organ of mine was blocked, while at the same time continuously running, regardless of how much I cleared it. Now, you might find this too privateother peoples snot can be even more difficult to deal with than ones ownbut it is necessary to outline how relatively common symptoms turned into something quite unexpected.

There was no feverthe rest of my fifty-year-old body felt perfectly fine. There was just this blocked, and simultaneously running, nose of mine. After a month, I went to see a doctor in Stockholm who prescribed a course of antibiotics. But the snot kept running and the nose remained blocked. Two weeks later I went back to the clinic and, as it goes with the medical system in Sweden, I saw another doctor, only to be prescribed another course of the same antibiotics. It was high summer in Sweden and I began to feel out of place with my out-of-the-ordinary nose. I had to organize a special high-volume delivery of tissues to the island in the Stockholm archipelago where I spent vacation. Still no improvement. It was exhausting, and terribly annoying.

There was no other choice than to visit the doctor again. This third doctor determined that the problem was the kind of antibiotics I had been taking, and quickly prescribed another brand which would surely stave off the problem. This was at the end of July, the day before I would leave for South Korea to install and inaugurate the 11th Gwangju Biennale. Temperatures past 40 degrees Celsius and high humidity levels welcomed me there. All the while my nose was running, and still blocked. Then grinding headaches appeared with increasing intensity, which sometimes prevented me from speaking. Finally, my biennial colleagues convinced me to go to the emergency room at the local hospital, where I signed in at 5 p.m. on a Friday afternoon.

By 9 p.m. the same evening I was lying on a surgery table, surrounded by a swarm of people dressed in white. A scan had revealed that the entire sinusfrom the hollow parts around the nose up to the forehead, and further still to the paranasal cavities in the cranial boneswas full. My brain and eyes were threatened. The sinus turned out to be completely stuffed with nasal secretion so thick that it could only be removed mechanically. I was put to sleep, and upon awakening, my nose was sore. Very sore. The anesthetics made me nauseous. Smiling, a friendly doctor reported that the surgery went well: my sinus had been successfully emptied. They had also identified the cause of my peculiar nasal adventure: a creature. To be precise, a fungus. This particular fungus is common in hot and humid areas across the planet, thriving inside human noses, where it is wonderfully warm, damp, and dark.

In other words, for almost three months I had lived with another living entity. But this fellow traveler was different from the kilograms of bacteria we carry around. This fungus had decided that my body, my sinus, was perfect for its development. Expressing my surprise to the doctor, he in turn shocked me when he confessed that while I was under anesthesia, he had taken the liberty of performing a nose job on me. Which he then followed by asking if I enjoyed downhill skiing in that faraway northern homeland of mine. Though downhill skiing always frightened me and I had gone to some lengths to avoid it at school, the news of the nose job frightened me even more. Considering how popular it is for women in South Korea to reshape their noses, which mostly means diminishing them, and not having looked at a mirror after the surgery, I feared the worst. In Korean terms my snout is big, and a nose job would have surely provided me with a smaller one. As I scrambled for my purse containing my pocket mirror, the doctor continued: we discovered that your right nostril was narrow and crooked, so we have widened it and straightened it out.

While this might have amused Freud, who also had issues with his nose, it would probably have been less entertaining to his close friend, the nose, ear, and throat doctor Wilhelm Fliess. Interested in the relationship between the nose and the genitals, Fliess introduced the concept of nasality instead of anality. According to Fliess, the nose is simply a sign of the penis, with the swelling of nasal mucosa leading to a Fliess syndrome. Freuds nose problems were subsequently treated by Fliess, an otorhinolaryngologist who experimented with cocaine as an anesthetic. Freud fared better than another of Fliesss patients, Emma Eckstein, who was treated by Freud for hysteria and became a psychoanalyst herself. Fliess almost killed her by forgetting gauze inside her nose while operating on it. This unfortunate event led to one of Freuds most well-known dreams concerning Irmas injection, which became key to The Interpretation of Dreams. The dream is said to deal with Freuds anxiety around allowing Ecksteins mistreatment, through the dream function of displacing the latent contentwhich is connected to wish fulfillmentwith manifest content, i.e., the scenario of the dream. It is noteworthy that the nose has played such a seminal role in the development of the principle of displacementa major trope for todays contemporary art.

Whereas Freuds and Ecksteins noses were given medical treatment, in Nikolai Gogols satirical magical realist story in St. Petersburg, the nose disappears. One morning a barber finds a nose in his breakfast bread, while at the same time a civil servant looking for a pimple discovers that his entire olfactory organ has gone missing. Wild speculation about the disappearance and fate of the nose arise, until one day it comes parading down Nevsky Prospect wearing a full uniform and a plumed hat. The sword-carrying nose continues traveling around the city claiming to be a state councilor until the police return it to its rightful owner, who returns it to its rightful place. Expressing his befuddlement, Gogols civil servant exclaims that authors ought to write about such a strange thing happening.

Goldin+Senneby, Insurgency of Life at e-flux, New York, 2019. Installation view. Courtesy: the artists. Photo: Gustavo Murillo Fernndez-Valds.

And here I am, attempting to put my own nasal adventure into words. It feels a bit odd as I am not used to writing about myself, and even less about my body. And yet, this adventure was a transformative experience: a close, even intimate, encounter with another creature, a new arrival reminding me of the relentless contingency of the life I live alongside so many others. In Donna Haraways terms, I ended up being-in-encounter with another critter. I had an inner sputnik, a traveling companiona stowaway to be precise. For a moment, our shared material habitat made us companion species, where the one invisible to the naked eye almost knocked out the towering host. Not only did the experience lead to a very situated knowledge, it was indeed a multispecies encounter that surpassed sympoeisis to become making kin. I was forced to coexist with this other creature, and I had to deal with the situation and accept our shared condition. Eventually the kinship did not work out. I had the upper hand and forced the fungus out of my body, with the help of Western medicine practiced by a South Korean doctor.

Insisting on multi-relationality across conventional borders, Haraways writing, and especially her neologisms, practice the worlding that she describes. She hints at this implying the creation of something that goes beyond the status quo: internally and externally, this planet can no longer afford to remain the same. Like artists, she gives form to what is not yet there for us to grasp. She is trying to take response-ability for the condition we are in by using a new vocabulary to emphasize critical points. A new condition inevitably demands other ways of describing and dealing with it. Just as a young revolutionary society like the nascent Soviet state and its hitherto unheard of form of society needed a new human, it also needed new forms of relationships between people. In this way, Haraways Terrapolisa speculative fabulation of a space for multispecies becoming-withcan be compared to the strongest contemporary art projects, or, in her words, art science worldings as sympoietic practices for living on a damaged planet.1

The allergic fungal sinusitis I was diagnosed with probably had to do with my allergic sensitivity to pollen and cats, as well as all fresh fruit and most vegetables. As a psychological and social tendency, oversensitivity is familiar in popular culture as well as in the fine arts. We know a lot about high-strung individuals and their inner life, whether male geniuses, hysterical women, or something in between. In comparison, physical oversensitivity is not very well understood in medicine, culture, or society. And yet I share the condition with many other people. The World Allergy Organization states that 10 to 40 percent of the worlds population suffers from allergies. They predict that by 2025, half of the population of Europe will suffer from one allergy or another.2

It is well-known that allergies are the immune systems response to substances it cannot tolerate, treating otherwise harmless material in its environment as threats to be fought. The normal condition for the body should be peacethere is no reason per se to fight pollen, cats, fresh fruit, or even vegetablesyet this condition causes the body to forcefully defend itself, even declare war against enemy invaders. It is a kind of corporeal alarm giving way to a state of exception for the organism. This in turn can easily become a semi-permanent or even permanent state of exception, as with long-term states of emergency in countries like Syria, where it lasted for nearly fifty years (1963 to 2011), or for two years (2015 to 2017) more recently in France.

In reality, this immunological condition is a distant relative to autoimmune diseases such as AIDS and multiple sclerosis. These diseases are markers of our time; where the former carries the burden of a stigmatized new disease signifying an important moment of both solidarity and hostility in Western societies, the latter primarily afflicts the wealthy northern hemisphere. Furthermore, multiple sclerosis is three times more likely to be found in women than in men, which is fitting for a disease first described in 1884 by the neurologist Jean-Martin Charcot, who famously researched female hysteria, and who also had considerable influence on Freuds work.

Goldin+Senneby, Insurgency of Life at e-flux, New York, 2019. Installation view. Courtesy: the artists. Photo: Gustavo Murillo Fernndez-Valds.

Curating Goldin+Sennebys exhibition Insurgency of Life at e-flux in New York last year brought me back to issues of autoimmunity. The exhibition centers on a fungus called Isaria sinclairii, and was introduced by the artists with the following passage:

You remember it as a stressful period.You had started a new job and your relationship was out of balance. Your partner had left for France and communication was difficult. You travelled to Paris so you could talk.Your left foot went stiff.Part of your abdomen went stiff, just around the solar plexus.Actually maybe more numb than stiff.The kind of numb, tingling sensation that you can have when your arm falls asleep. The pins and needles sensation. For a moment you cant locate your arm. You cant move it.Only this time the moment of numbness, of paresthesia, was extended. It went on too long. Your foot was numb. Your solar plexus was numb. And it wouldnt go away.You assumed it was psychological. Related to stress. The emotional stress of your crumbling relationship.

In an elongated clinical space with pale violet walls and bleachers at either end, the Isaria sinclairii fungus was cultivated with vast amounts of nutrient agar in a stainless-steel pool on legs. Contrary to that of my ex-boyfriend, when unblocked my nose is one of my most developed senses. Already before entering the exhibition during install I was worried about the potential smell of this impressive fungal pool, and the prospect of another habitat being made in my nose. As I entered, the smell was distinct but faint, vaguely similar to a forest. Used as a youth elixir in traditional Chinese medicine, this fungus is hyper-selective, or we might say oversensitive, in its choice of habitat. In the wild, it seeks out and exclusively grows on cicada nymphs when they are hatching below ground. After colonizing the cicada, the fungus eventually grows and sprouts from its head. This violent drama, whose visual appearance is not unlike images of the so-called mushroom clouds of atomic bombs, was captured by Goldin+Senneby on a large X-ray photograph hung on the wall facing every visitor entering the exhibition space. Again, I was reminded of my fungus, which similarly threatened my eyes and my brain.

The Isaria sinclairii fungus cultivated in the exhibition is used in a medication called Gilenya, which 50 percent of Goldin+Senneby, Jakob Senneby, used to take for multiple sclerosis. Diagnosed with the nervous system disease in 1999, Senneby participated in a clinical trial for this new medicine developed by the pharmaceutical multinational Novartis as the first ever pill-based MS treatment. As all treatments of autoimmune conditions suppress the immune system, the long-term consequences of such treatments are still largely unknown. In the US, the FDA recently warned that stopping Gilenya could cause severe flush-out effects that can worsen the condition severely and irreversibly. It is well-known that pharmaceutical companies, like insurance companies, are some of the most aggressive data harvesters of our time. Learning from patients posting tutorials on YouTube, the artists had ten Lego robots made, each carrying a smartphone rocking back and forth to making the pedometers tick. The rocking sound became a soundtrack that might have sounded like grown-up cicadas at dusk who, unlike their young counterparts, escaped the cruel fungus.

These DIY cheating machines are meant to trick the insurance companies who monitor physical activity to discount the cost of health care. Similar to the demand that Facebook should pay wages to those who indirectly work for them by providing content through our online activities, the Lego robots restore value to those who are deemed sick. Just as we might demand the restitution of ancient artworks and other objects, we might do the same with the most intimate of things: our body. As a way to reclaim the biological human bodyand prevent the invasion of privacythe Lego robots are a refusal to comply with a wholesale capitalization of very individual experiences, extracting ever more data, presumably indexical data, to most likely be used for marketing or research, the risks of which became apparent to Senneby in the Novartis trial.

As a focal point in the exhibition, the fungus-cultivating pool took as a reference Lucas Cranach the Elders painting Fountain of Youth from 1546. Set in a forest with fantastical mountains in the background, the painting centers on a rectangular pool with steps on each side descending into the water. If the exhibition space at e-flux bore some resemblance to an anatomical theater, the painting offers the image of a stage for a drama of revitalization. Herodotus described how the fountain of youths magic water grants eternal life, and Cranachs painting depicts old, crippled, and feeble women being taken to the pool in carriages and wheelbarrows to receive a rejuvenating bath, from which they emerge on the right side of the painting with smooth and erect bodies and long, wavy ginger hair. Awaiting them on this side are knights and other men with whom the rejuvenated maidens dine, dance, and probably engage in some amorous activities. In our own era, such erotics of longevity and immortality are expressed differently, from Silicon Valley executives receiving transfusions of teenage blood to more general longings for healing, convalescence, and recovery from any and all disease.

In a small room at the back of the exhibition space, a series of surrealistic drawings bore the iconography of the story of Insurgency of Life. Each drawing was made of ten layers stacked on top of each other, with cut-out holes in each layer, and were inspired by Tove Janssons acclaimed 1952 childrens book The Book About Moomin, Mymble, and Little My.3 As a story about a motley crew of critters imbued with a strong sense of both magic and realism, they could be a distant cousin of Gogols story, giving space to the fantastical while the relationships and feelings of the characters are plausible and realistic. A unique feature of Janssons book is that each spread has a hole allowing the reader to peek onto the following spread. In the story, Moominwho, like all Moomin trolls, has an enormous round nose that would have intrigued both Freud and Fliessis supposed to bring a bottle of milk to his mother. Carrying it through a forest and a rocky landscape, Moomin encounters a mix of scary and friendly creatures, all sharing the harsh weather conditions. When he finally reaches his mothers sunny, blossoming garden, the milk is sour. But rather than the storyline, it is the form of the book that is of interest: the peek onto the next spread underscoring connections and relations, continuity and storytelling.

To work sequentially with a particular project over an extended period of time is characteristic of Goldin+Sennebys work. Each component leads to the next, planting seeds for the sequels. Made up of multiple parts, this long-haul tactic requires a sort of persistence to be able to stay with the trouble (in Haraways words) and tell an incredibly complicated story emphasizing interconnectivity, causality, and a certain kind of feedback. Yet, despite the physical body of the artist being out of sight, it is at the very center of Insurgency of Life. It is the site. Like in Mary Kellys 1976 feminist classic Post-Partum Documenta six-year inquiry into childbirth and the development of the relationship between the mother and the infantthe body itself is nowhere to be seen. Such a displacement is followed by real indexical objects: for Kelly, diapers and parts of blankets, while for Goldin+Senneby the body is displaced by the body of the fungus. Avoiding anthropomorphism without abandoning the materiality of the body becomes a way to make something highly personal without being private. Simultaneously, and in contrast to their previous work, the artists are suddenly present in the flesh, doing a lecture performance at the opening.

Goldin+Senneby with Johan Hjerpe, Illustration in Seven Layers, 2019. Courtesy: the artists. Photo: Gustavo Murillo Fernndez-Valds.

With Insurgency of Life, life itself has broken into the work of Goldin+Senneby, opening a view onto a situation that has accompanied the duo since they started working together fifteen years ago. However, this situationand its stark medical realityhas not been detectable in their art until now. Between care and extraction, this version of the retrospective traced a physical condition, not a sequence of works. Forming the third and final part of a trilogy of retrospectives, the New York edition quite literally entered a different kind of biopolitics than both their previous work and their retrospectives in Stockholm and Brisbane.4 In New York, the duo relied again on a group of steady collaborators, outsourcing many parts of the work. Compared to their multi-year project Headless, Insurgency of Life is less concerned with neoliberal subterfuge. While they still outsource many tasks, with time, their service providers have become more like collaborators. In this way, they are foregrounding a network of dependencies more than one of anonymities. Accepting this kind of proximity and continuity does appear to become a process of immunization.

The exhibition was also the beginning of a new novel, written incrementally by the acclaimed author Katie Kitamura. As opposed to Headless, Goldin+Sennebys experimental 2015 novel, this new novel has exited the world of offshore finance only to enter the field of gene manipulation and bio-capitalism. During the course of the exhibition, a performance entitled Crying Pine Tree took place at Triple Canopy, where Kitamura read from her first chapter of the new novel. Here, the main character, a gene-manipulated and autoimmune pine tree, encounters an investor and a geneticist who accelerate and exaggerate the immune system of the conifer in order to make it produce more sap. As a source for clean energy, the sap might prove in the long run to be a kind of liquid gold, in addition to being a natural disinfectant used since antiquity to treat wounds. Hovering between science, art, and fiction, the narrative of the novel displaces the immunological concerns of MS onto the flora. For years to come, the writer and the artists will feed each others creative process by allowing each step to infuse the next one.

But what is the body at stake here? It is an artistic double-bodyindividual and singular, yet at the same time collectivewhich already complicates the tradition of retrospective exhibitions. Compared to a lot of performance and body art of earlier decades, the relation of this double-body to the self is already intensely, and differently, politicized. Whereas before, it elaborated the elusive anonymity of offshore finance in Goldin+Sennebys Headless, today it opens onto the absolute situatedness of disease. Now it is springtime again, and as I am blowing my nose in self-imposed quarantine due to Covid-19, I have begun to suspect those of us affected by immune-related conditions to be an involuntary avant-garde. Placed at the forefront of how illnesses develop today, our bodies become the site for a parallel climate change from within. In order to begin to grasp this, we need, among other things, a sequel to Michel Foucaults 1961 Madness and Civilization: A History of Insanity in the Age of Reason. Perhaps it should be called something like Oversensitivity and the Planet: A History of Immunity in the Age of Profit.

Maria Lind is a curator, writer, and educator based in Berlin and Stockholm. She is a lecturer at Konstfacks CuratorLab. In 2019 she published Seven Years: The Rematerialisation of Art from 2011 to 2017 with Sternberg Press. She is the coeditor of the recent publications Red Love: A Reader on Alexandra Kollontai; The New Model: An Inquiry; and Migration: Traces in an Art Collection. On the first of January 2020 she launched the Instagram project 52proposalsforthe20s with fifty-two artists invited to make weekly proposals for the new decade.

2020 e-flux and the author

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What Is Wrong with My Nose: From Gogol and Freud to Goldin+Senneby (via Haraway) - Journal #108 April 2020 - E-Flux

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Coronavirus crisis has transformed our view of whats important – The Guardian

Posted: at 5:47 pm

There are decades where nothing happens; and there are weeks where decades happen.

So said Vladimir Ilyich Lenin of the ferment of revolution, but he could just as easily have been talking about the 100 days that have passed since the moment coronavirus officially became a global phenomenon, the day China reported the new contagion to the World Health Organization.

The world has been transformed in that time, perhaps nowhere more so than Britain.

A hundred days ago, on 31 December, the UK prime minister delivered a video message full of hope and promise.

The coming year would, he said, be a fantastic one, the start of an exhilarating decade of growth, prosperity and opportunity. In 2020, he enthused, Britain would brim with confidence.

The early weeks suggested the PM might be right on one count at least. After three and a half years of rancour over Brexit, some of the poison began to drain out of the issue. Of course, it wasnt done, as Johnson promised it would be, but it seemed as if we might dwell on lesser worries.

We saw in 2020 debating Megxit, a country with no greater angst on its mind than whether the Sussexes should carry on royalling.

On 31 January, the UK formally left the European Union. This new coronavirus was low down on the bulletins, safely tagged as foreign news.

Even by early March, it had not quite bared its teeth. People knew the official advice but werent sure quite how seriously they were meant to take it. Those politicians involved in public health messaging might attempt an awkward elbow bump at the start of a meeting, only to end it with a handshake or even a bear hug.

Johnson himself, at a press conference on 3 March, cheerfully boasted that he was still shaking hands with people he met including, he said, people infected with coronavirus.

And yet, after a couple of those weeks in which decades happen, on 23 March Johnson was delivering a TV address to the nation, announcing a lockdown in what might have been a hackneyed scene from dystopian fiction. The pubs were closed, along with the football grounds and the cinemas and the theatres and the schools. Places that normally throb with noise were suddenly quiet and have remained so.

You can jog through Leicester Square, London, a place normally teeming with tourists, and hear nothing more than the flapping of a distant flag.

Two weeks on from that original edict and now the death toll is in the thousands with the prime minister himself in intensive care, a development that shook people who did not expect to be shaken. Decades, in weeks.

This is a story of change so rapid, we can barely absorb it.

People focus on the questions that are human scale and therefore digestible how long is the queue outside the supermarket? Do I need to wash vegetables if theyre wrapped in plastic? Can I walk in a park if everyone else is walking in the same park? perhaps because the larger questions are too big to take in, including the largest of all: is this plague going to kill someone I love? Will it kill me?

This is the greatest UK public health crisis in a century. It threatens a death toll in five figures. It dwarfs any such menace since the Spanish flu afflicted a nation already staggering from the losses of the first world war. Perhaps it will come to seem like an act of God that none of us could have done anything about, a plague on all our houses that could not be averted.

Or maybe a future public inquiry will examine the fact that doctors and nurses were denied basic protective equipment, that care workers were forced to use bin liners for aprons and Marigolds for gloves, along with the paucity of ventilators and, above all, Britains apparent inability to follow the WHOs instruction to test, test, test, and conclude that the UK response to Covid-19 ranks as one of the severest failures of public administration in the countrys long history.

That makes this a political crisis.

They were very slow. They didnt understand the scale of this, says one senior figure, who has witnessed the governments response close up. He says those at the top were blase, that emergency Cobra meetings were nothing like the efficient coordination exercises that have followed terror attacks, but chaotic, lacking decisiveness.

As for the PM, I was surprised at how not in control Johnson appeared to be. There was a lack of comparative data on how other countries were responding, a lack of thinking strategically or several moves ahead. Put simply, he says, the government was winging it.

The cabinet has looked callow in this period, lacking the seasoned faces of cabinets past. Dominic Raab, Rishi Sunak, Matt Hancock: they dont have that many years on the clock.

Every time a Michael Heseltine or Gordon Brown comes on the radio, social media brims with nostalgia for the heavyweights of yore.

Its one reason why the weekend just gone seemed to calm nerves. On Saturday, Labour elected a new leader who looked competent and capable. That brought one sigh of relief. Sunday brought another, as the country heard from its longest-serving public figure, its head of state.

The Queens ability to reassure rests on her status as monarch, of course, but also on her extraordinary longevity at the centre of our national life. As she reminded viewers of her TV address that night a vanishingly rare event in itself she has been communicating with Britons at moments of distress for an astonishing 80 years.

She recalled broadcasting to child evacuees in 1940, thereby summoning up the mystic power of the event which serves as the foundation story of modern Britain the moment when we stood alone against an evil menace, and prevailed. Her promise that we will meet again, at once a glance back to the wartime past and a glimpse of a more hopeful future, will be remembered as one of the most significant because necessary acts of her 68-year reign.

Had the weekend ended that way, a calm might have settled on the land. As one observer noticed, the Queens message, along with Starmers election, suggested the scaffolding of the British state was being hoisted back into place.

But the calm lasted less than an hour, the nerves jangling once more with the news that the PM had been taken to hospital proof that even the most protected individual in the country, a Falstaffian figure of hale and hearty vigour, was not beyond the claw of this dreaded virus.

Even so, despite the fear and the loneliness and the claustrophobia and the economic hardship of lockdown, few would say the country has sunk into despair.

Privately, our lives have been pared down to their barest essentials: no sport, no live entertainment, no nights out just work, for those who still have it, family and remote contact with friends.

The work has changed all laptops, pyjamas and Zoom for those who once toiled in offices while family life has changed too, becoming much more concentrated and intense.

For some, that has been an unexpected joy; for others, it has been suffocating and even dangerous.

But our public life has also been stripped to its essentials. Weve come to see whats indispensable and what is not.

It turns out that we can function without celebrities or star athletes, but we really cannot function without nurses, doctors, care workers, delivery drivers, the stackers of supermarket shelves or, perhaps unexpectedly, good neighbours.

If you didnt value those people before some of those belatedly recognised as key workers are among the lowest paid you surely value them now. In a new tradition, we emerge from our homes and start clapping every Thursday night at 8pm to make sure they know.

Almost everything the prime minister predicted a hundred days ago has failed to come true: 2020 will not be a year of growth or prosperity, but the very opposite. And yet, on one thing he was right. Somehow, we have left the widest rift of recent years behind.

Leave or remain now feels like an ancient divide, made suddenly irrelevant when the only distinction that matters is alive or dead.

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Disease is the greatest threat to bee health. Can we protect them through genetically engineered probiotics? – Genetic Literacy Project

Posted: at 5:46 pm

If you cannot engineer the organism, engineer its microbiome.

Since scientists began exploring how to solve problems using synthetic biology, by focusing on microbial symbionts, a whole universe of possibilities has opened up. We have seen a hangover cure, synthetic probiotics for humans, and even microbes that help plants fix their own nitrogen. Now the focus is on bees to get their engineered probiotic, an idea that may save the insects from disease and insulate consumers from food shortages.

Domesticated bees and other pollinators play a significant role in growing many foods, although how much is debated. A significant percentage of Americas crops between 7% and 35% relyto some extent on bees. Wheat, corn and rice are wind-pollinated. Lettuce, beans and tomatoes are self-pollinated. But in some crops, bees are essential. Honeybees have a tremendous financial importance, not only for their honey but as the insects that enable the reproduction of (many) flowering plants. As wild insects cannot be relied upon to pollinate thousands of acres of monocultures, crop producers employ beekeepers to bring their hives close to their plants. This gave birth to migratory beekeeping, a practice now essential for cultivation of plants such as almond trees on a commercial scale.

Honeybees have evolved into a managed livestock, with a complex role in agriculture and established production and management practices. Beekeepers need to maintain healthy colonies. All bee colonies decline significantly in size during the winter months, but overwinter losses have increased over the past 15 years, and now hover around 40%. These persistently high mortality rates have fedinaccurate speculations about the cause, often blaming one class of pesticides, neonicotioids as the primary culprit. The evidence doesnt support that claim. The driver of bee health problems is known and its not pesticides nor agricultural production models; its disease.

Honeybees are susceptible to many infections from parasites and viruses. In fact, the co-infection with mite parasites and RNA viruses is particularly destructive for bees and accounts for a large portion of colony losses. The most common external parasites are the Varroa mites (scientific name Varroa destructor), which feed on the fat bodies of the bees. The deformed wing virus is another common hazard. This RNA virus uses the Varroa mites as disease vectors and infects the bee bodies, leading to developmental deformities.

Varroa infection treatment is difficult. Common methods include pesticides to which Varroa started developing resistance mechanical screening of bees, as well as teaching the bees to recognize and kill infected pupae. A more selective and effective treatment could save bees and agricultural resources, and this treatment might be already present in the bees gut microbiome.

In animals, DNA stores the genetic material, and RNA molecules are short-lived and execute specific functions. Ribosomal RNA has structural role in ribosomes, transport RNA carry amino acids, and messenger RNA carries the information needed to synthesize proteins. In contrast, many viruses carry their genetic information in RNA molecules. To defend against RNA viruses, cells have developed a sophisticated system called RNA interference, or RNAi. This complex molecular machinery recognizes double-stranded RNA and breaks it down.

Bees possess an efficient RNAi machinery that protects them from intruders at a molecular level. And researchers can use this system to protect bees against mites and viruses. If we insert RNA complimentary to the deformed wing viruss genome, it will form a double-stranded hybrid molecule. The RNAi machinery can now shred the virus genome to pieces, ending thus the virus infection. The same principle can be used to target specific parasite genes. And this brought forth the idea of injecting bees with RNA to protect against Varroa mites.

There are several problems with administering RNA to individual bees. RNA is a notoriously unstable and difficult to administer molecule. The treatment is short-termed. There are off-target effects. And its almost impossible to treat entire hives. Ideally, the bees would maintain the ability to produce the suitable RNA for a long time (or permanently), but would express it only in case of infection is happening. In theory it should be possible to insert the RNA gene in the genome of the honeybees under very tight control. In practice, though, this would be extremely tough. But while the process of genetically engineering insects is not very practical, the technology to modify bacteria is quite mature.

Bees, as every organism, have a rich microbiome. It should be possible modify one of these microbes to deliver the RNA cure to its bee hosts. This is exactly the idea researchers from the University of Texas explored in a recent article published in Science. Sean Leonard and his collaborators genetically modified the bacterium Snodgrassella alvi wkB2, one of the most abundant microbes found in the honeybee gut, to continuously deliver double stranded RNA.

The researchers first verified that engineered bacteria can establish themselves in the bees gut. They tested whether the modified S. alvi can deliver RNA to their host, and if this RNA can stimulate an RNAi response. As these early experiments were positive, the scientists tried to use the new probiotic to treat deformed wing virus and Varroa mite infections. Their results showed that the administration of the engineered microbe improved survivability, while the microbe by itself didnt seem to harm healthy bees.

This work from Leonard and the rest of the University of Texas team is an encouraging proof of principle. Their study shows that bee probiotics can confer parasite and virus resistance for several days to individual bees, though they dont show yet if such a treatment will work well on a hive level. Such an approach has the potential to be a versatile and generalized cure: the beekeepers could store and administer specialized probiotics for any possible outbreak. Bee probiotics would be very specific to the disease they teat and they would have minimal environmental impact (contained within the hives and disappearing over time).

Would honeybee probiotics get regulatory clearance? The question is a bit complicated. In the US, they would likely be regulated in same way as engineered human probiotics, which are already on the market. But the honey produced by treated bees and the pollinated crops are in regulatory uncharted territory, so nothing is assured as this issue is more ideological than science-based. The food products are definitely not GMOs as the bee or crop DNA would not be affected but regulators might nonetheless under political pressure to require proof about environmental and food safety, even though there is no logical scientific basis for requiring such information as there would be no detectable difference in honey derived from such bees. Most probably, countries with tougher GMO restrictions (such as in the EU) will be as skeptical of probiotics from RNA-modified bees as they are of other genetic engineering technology, and are unlikely to approve them.

Insects are organisms with immense financial, ecological, and social importance. Synthetic biology may provide ways to protect or control insect populations without the use of harmful chemicals, destroying habitats, or introducing invasive species ways that we currently employ with well-documented consequences. Engineering the microbiome is a way to solve biological problems by bypassing the hurdles of transforming complex multicellular organisms, a back door to make synthetic biology easier. And the honeybee back door is now pried open.

Kostas Vavitsas, PhD, is a Senior Research Associate at the University of Athens, Greece. He is also a steering committee member of EUSynBioS. Follow him on Twitter @konvavitsas

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CSL Behring and SAB Biotherapeutics Join Forces to Deliver New Potential COVID-19 Therapeutic – P&T Community

Posted: at 5:46 pm

KING OF PRUSSIA, Pa. and SIOUX FALLS, S.D., April 8, 2020 /PRNewswire/ --Global biotherapeutics leader, CSL Behringand innovative human antibody development company SAB Biotherapeutics(SAB) announced today their partnership to combat the coronavirus pandemic with the rapid development of SAB-185, a COVID-19 therapeutic candidate on track for clinical evaluation by early summer. The partnership joins the forces of CSL Behring's leading protein science capabilities with SAB's novel immunotherapy platform capable of rapidly developing and producing natural, highly-targeted, high-potency, fully human polyclonal antibodies without the need for blood plasma donations from recovered patients.

The therapeutic candidate, SAB-185, is generated from SAB's proprietary DiversitAb platform producing large volumes of human polyclonal antibodies targeted specifically to SARS-CoV-2, the virus that causes COVID-19. Driven by advanced genetic engineering and antibody science, SAB's novel approach, leveraging genetically engineered cattle to produce fully human antibodies, enables a scalable and reliable production of targeted, higher potency neutralizing antibody product than has been previously possible. SAB's approach has expedited the rapid development of a novel immunotherapy for COVID-19 deploying the same natural immune response to fight the disease as recovered patients, but with a much higher concentration of targeted antibodies.

"COVID-19 is a nearly unprecedented public health crisis," said CSL Behring's Executive Vice President and Head of R&D Bill Mezzanotte, M.D. "That's why we're combining our leading capabilities in plasma product development and immunology with external collaborators to help find multiple, rapid solutions. In the near-term, SAB Biotherapeutics' novel immunotherapy platform provides a new and innovative solution to rapidly respond without the need for human plasma adding a different dimension to the industry-wide plasma-derived hyperimmune alliance effort we recently launched for the COVID-19 crisis. For future pandemics, SAB's platform may allow us to even more rapidly respond to patients' needs."

"Our targeted high-potency immunotherapies leverage the native immune response thereby providing a highly-specific match against the complexity, diversity and mutation of a disease," said Eddie J. Sullivan, PhD, SAB Biotherapeutics president, CEO and co-founder. "Our partnership with CSL Behring shifts our development trajectory to more rapidly scale-up and delivery of our highly targeted and potent COVID-19 therapeutic candidate, and deploy our unique capabilities to help combat this crisis. We have a successful preclinical track record for addressing infectious disease targets including Ebola, MERS, and SARS with our proprietary platform and appreciate that this collaboration with a global biopharmaceutical powerhouse will magnify the potential impact of a COVID-19 immunotherapy and provide an important framework for establishing sustainable solutions for the future."

CSL Behring has provided seed funding to offset some initial development costs that were funded by SAB in good faith, responding to the global pandemic as quickly as possible. SAB has already secured approximately $7.2 million in funding through an interagency agreement with the Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense (JPEO - CBRND) and Biomedical Advanced Research and Development Authority (BARDA)to support SAB to complete manufacturing and preclinical studies. CSL Behring will then commit its clinical, regulatory, manufacturing and supply chain expertise and resources to deliver the therapeutic to the market as soon as possible, on terms to be agreed with SAB.

Earlier this year, the companies announceda collaboration to investigate SAB's platform technology as a new source for human immunoglobulin G (IgG) and the potential for new therapies to treat challenging autoimmune, infectious and idiopathic diseases by leveraging SAB's DiversitAb platform.

About CSL Behring CSL Behring is a global biotherapeutics leader driven by its promise to save lives. Focused on serving patients' needs by using the latest technologies, we develop and deliver innovative therapies that are used to treat coagulation disorders, primary immune deficiencies, hereditary angioedema, inherited respiratory disease, and neurological disorders. The company's products are also used in cardiac surgery, burn treatment and to prevent hemolytic disease of the newborn. CSL Behring operates one of the world's largest plasma collection networks, CSL Plasma. The parent company, CSL Limited (ASX:CSL;USOTC:CSLLY), headquartered in Melbourne, Australia, employs more than 26,000 people, and delivers its life-saving therapies to people in more than 70 countries. For more information, visit http://www.cslbehring.com and for inspiring stories about the promise of biotechnology, visit Vita http://www.cslbehring.com/Vita

About SAB Biotherapeutics, Inc.SAB Biotherapeutics, Inc. (SAB), headquartered in Sioux Falls, S.D. is a clinical-stage, biopharmaceutical development company advancing a new class of immunotherapies leveraging fully human polyclonal antibodies. Utilizing some of the most complex genetic engineering and antibody science in the world, SAB has developed the only platform that can rapidly produce natural, highly targeted, high-potency, immunotherapies at commercial scale. The company is advancing programs in autoimmunity, infectious diseases, inflammation and exploratory oncology. SAB is rapidly progressing on a new therapeutic for COVID-19, SAB-185, a fully human polyclonal antibodies targeted to SARS-CoV-2 without using human donors. SAB-185 is expected to be ready for evaluation as early as summer 2020. The company was also recently awarded a $27 million contract from the U.S. Department of Defense (DoD) to leverage its unique capabilities as part of a Rapid Response Antibody Program, valued at up to $27 million. For more information visit: http://www.sabbiotherapeutics.com.

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CAR T-Cell Therapy for Multiple Myeloma – Global Market Insights and Market Forecast to 2030 – ResearchAndMarkets.com – Yahoo Finance

Posted: at 5:46 pm

The "CAR T-Cell Therapy for Multiple Myeloma - Market Insights and Market Forecast - 2030" report has been added to ResearchAndMarkets.com's offering.

This report delivers an in-depth understanding of the CAR T-Cell Therapy use for Multiple Myeloma as well as the CAR T-Cell Therapy market trends for Multiple Myeloma in the 6MM i.e., United States and EU5 (Germany, Spain, Italy, France and the United Kingdom).

The Multiple Myeloma CAR T-Cell Therapy market report provides current treatment practices, emerging drugs, CAR T-Cell Therapy market share of the various CAR T-Cell Therapies for Multiple Myeloma, the individual therapies, current and forecasted Multiple Myeloma CAR T-Cell Therapy market Size from 2017 to 2030 segmented by seven major markets. The Report also covers current Multiple Myeloma treatment practice/algorithm, market drivers, market barriers and unmet medical needs to curate best of the opportunities and assesses underlying potential of the market.

Reasons to Buy

Report Highlights

Key Topics Covered:

1. Key Insights

2. Executive Summary

3. CAR T-Cell Therapy Market Overview at a Glance

3.1 Market Share (%) Distribution of CAR T-Cell Therapy for MM in 2030

4. CAR T-Cell Therapy Background and Overview

4.1 Introduction

4.1.1 CARs Generations

4.1.2 Genetic Engineering of T-Cells

4.1.3 How CAR T-Cell Therapy Works

4.2 The promise of CAR T-cell targeting B cell maturation antigen (BCMA) in multiple myeloma

4.3 Current challenges in CAR T

4.3.1 Therapeutic side effects

4.3.2 CAR T-cells lack of success

4.4 CAR T-cell therapy: Route to reimbursement

4.5 Unmet needs

5. CAR T-Cell Therapy for Multiple Myeloma (MM): 6 Major Market Analysis

5.1 Key Findings

5.2 Market Size of CAR T-Cell Therapy in 6MM

5.2.1 Market Size of CAR T-Cell Therapy by Therapies

6. Market Outlook

7. Emerging Drug Profiles for Multiple Myeloma

7.1 bb2121: Celgene Corporation

7.1.1 Product Description

7.1.2 Research and Development

7.1.3 Product Development Activities

7.2 JNJ-68284528 (LCAR-B38M): Janssen Research & Development

7.2.1 Product Description

7.2.2 Research and Development

7.2.3 Product Development Activities

7.3 P-BCMA-101: Poseida Therapeutics

7.3.1 Product Description:

7.3.2 Research and Development

7.3.3 Product Development Activities

7.4 CAR-CD44v6: MolMed S.p.A.

7.4.1 Product Description

7.4.2 Research and Development

7.4.3 Product Development Activities

7.5 JCARH125 (Orvacabtagene autoleucel): Celgene Corporation

7.5.1 Product Description

7.5.2 Research and Development

7.5.3 Product Development Activities

7.6 Descartes-08: Cartesian Therapeutics

7.6.1 Product Description

7.6.2 Research and Development

7.7 CT053 : CARsgen Therapeutics)

7.7.1 Product Description

7.7.2 Research and Development

7.7.3 Product Development Activities

Companies Mentioned

For more information about this report visit https://www.researchandmarkets.com/r/auj3ij

View source version on businesswire.com: https://www.businesswire.com/news/home/20200409005373/en/

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CAR T-Cell Therapy for Multiple Myeloma - Global Market Insights and Market Forecast to 2030 - ResearchAndMarkets.com - Yahoo Finance

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One in four Britons ‘think the coronavirus was probably created in a lab’ – Yahoo Sports

Posted: at 5:45 pm

One in four Britons think the coronavirus was probably created in a lab, research suggests.

Scientists from Kings College London asked more than 2,000 people what they believed to be true about the somewhat mysterious strain.

A quarter (25%) of those surveyed thought the coronavirus is probably man-made, a conspiracy theory circulating the internet.

Early research suggests the infection is mild in four out of five cases, however, it can trigger a respiratory disease called COVID-19.

A member of staff gives directions at a coronavirus testing centre for NHS staff at an IKEA in Gateshead, Tyne and Wear. (Getty Images)

The Kings scientists surveyed 2,250 people aged between 18 and 75.

Of the participants who thought the coronavirus was probably created in a lab, 12% admitted to meeting up with friends during the UKs lockdown.

This is more than double the 5% of participants who socialised with loved ones, but were convinced of the strains natural origin.

Latest coronavirus news, updates and advice

Live: Follow all the latest updates from the UK and around the world

Fact-checker: The number of COVID-19 cases in your local area

Explained: Symptoms, latest advice and how it compares to the flu

Boris Johnson has enforced draconian measures that only allow Britons to leave their home for very limited purposes, like exercising or shopping for essentials.

The prime minister, who is in intensive care with coronavirus complications, has repeatedly stressed people are not to socialise with those outside of their home.

Nearly a quarter (24%) of the Kings participants who believed the coronavirus was probably manufactured thought too much of a fuss is being made about the pandemic.

This is compared to one in 10 (10%) of those who believed the strain is natural.

Emerging at the end of last year, only the relatively small number of people worldwide who have encountered the virus are thought to have immunity against it.

The race is on to develop a vaccine that will enable herd immunity, allowing the public to safely go back to their normal routine.

The survey participants who thought a jab will be available within three months were nearly four times as likely to have met up with friends during the lockdown than those of the opinion a vaccine will take longer.

Numerous pharmaceutical companies around the world are working to develop a jab, however, scientists have been upfront one will not be ready for this outbreak.

A vaccine may become available, however, if the infection turns out to be seasonal.

People have generally got the message about how serious the threat from the virus is and the importance of the measures being required of them, said study author Professor Bobby Duffy.

But at a time when the government is warning it may bring in more severe restrictions if enough people dont follow the rules, this research shows there is a significant minority who are unclear on what some of them are, as well as many who still misjudge the scale of the threat from coronavirus or believe false claims about it.

And this matters how we see current realities and the future is often related to how we strictly we follow the guidelines and our attitudes to the lockdown measures.

A man wears a mask outside a closed electrical-goods shop in the centre of Munich. (Getty Images)

Story continues

The coronavirus is thought to have emerged at a seafood and live animal market in the Chinese city Wuhan, capital of Hubei province, at the end of 2019.

The market is said to have sold a range of dead and alive animals, including bats, donkeys, poultry and hedgehogs.

Most of those who initially became unwell at the start of the outbreak worked at, or visited, the Wuhan market.

This has led scientists to believe the new coronavirus jumped from an animal into a human while the two were in close contact.

The coronavirus is one of seven strains of a class of viruses that are known to infect humans.

Another strain is severe acute respiratory syndrome (Sars), which killed 774 people during its 2002/3 outbreak.

Sars is thought to have started in bats and jumped into humans via masked palm civets.

Research suggests the new coronavirus shares more than 96% of its DNA with a strain detected in horseshoe bats and may have reached humans via pangolins.

Despite the evidence, conspiracy theories have arisen suggesting the strain could have been engineered.

To debunk this, scientists from Scripps Research in San Diego analysed the DNA of the virus and others like it.

They specifically looked at proteins on the surface of the viruses that allow them to enter human cells.

Results suggested the coronavirus evolved to target a receptor on human cells called ACE2.

This targeting is so effective, the scientists concluded it was the result of natural selection and not genetic engineering.

The coronavirus genetic backbone is also distinct from other pathogens. The scientists argued if one were to manufacture a disease, they would work off a backbone that is known to cause ill health.

By comparing the available genome sequence data for known coronavirus strains, we can firmly determine that [the new strain] originated through natural processes, said study author Dr Kristian Andersen.

A woman wears a mask while walking dogs in Palma, Spain. (Getty Images)

Since the coronavirus outbreak was identified, more than 1.5 million cases have been confirmed worldwide,according to Johns Hopkins University.

Of these cases, over 339,700 are known to have recovered.

Globally, the death toll has exceeded 89,900.

The coronavirus mainly spreads face-to-face via infected droplets expelled in a cough and sneeze.

There is also evidenceit may be transmitted in faecesandcan survive on surfaces.

Although most cases are mild, pneumonia can come about if the coronavirus spreads to the air sacs in the lungs.

This causes them to become inflamed and filled with fluid or pus.

The lungs then struggle to draw in air, resulting in reduced oxygen in the bloodstream and a build-up of carbon dioxide.

The coronavirus has no set treatment, with most patients naturally fighting off the infection.

Those requiring hospitalisation are given supportive care, like ventilation, while their immune system gets to work.

Officials urge people ward off the coronavirus bywashing their hands regularlyand maintainingsocial distancing.

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One in four Britons 'think the coronavirus was probably created in a lab' - Yahoo Sports

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Fear of global plagues and greed for money are as old as mankind – SowetanLIVE

Posted: at 5:45 pm

Most of us have been taught to understand the word "historian" to refer to a specialist who writes about the past.

One of the greatest - if not the greatest - historians alive today is a 44-year-old man by the name of Yuval Harari, currently lecturing at the Hebrew University of Jerusalem, Israel.

Five years ago, Harari changed the meaning of "history" by publishing a book about the future - Homo Deus: A Brief History of Tomorrow.

The title of this prophetic book is pregnant with meaning. It combines two beings - earthly and divine - to produce an omnipotent hybrid called "Domo Deus".

In palaeontology, the prefix "homo" refers to creatures that evolved into the human family. In classical Latin, "Deus" meant "god". Thus, Harari's book envisions a future where man can appropriate the powers of "god", and therefore become a human-god or "Homo Deus".

In the first chapter, Harari writes about the "anti-death" scientific research under way at the well-known American company Google.

In 2009, one of the leading anti-death researchers at Google, Bill Maris, fervently believed it would be possible, through genetic engineering, for a human being to live until he is 500 years old.

That idea rests on a fundamental transformation of the meaning of "death" that has taken place in the mind of man - from the understanding of death as a mysterious occurrence preordained by a deity to death understood as, according to Harari, "a technical problem that we can and should solve".

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Fear of global plagues and greed for money are as old as mankind - SowetanLIVE

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