Monthly Archives: March 2020

Past Pandemics Exposed Chinas Weaknesses – Foreign Affairs Magazine

Posted: March 31, 2020 at 5:56 am

When the novel coronavirus first emerged in Chinas Hubei Province, foreign reactions to the countrys handling of the epidemic swung between extremes. At a press conference held in Beijing in late February, Bruce Aylward, who co-led the World Health Organizations (WHO) joint mission with China on the disease now known as COVID-19, praised what he described as probably the most ambitious, and I would say, agile and aggressive disease-containment effort in history. Pointing to a graph that showed a steep decline in cases, he commented, If I had COVID-19, Id want to be treated in China.

Others have been far more critical. In a Wall Street Journal opinion piece titled China Is the Real Sick Man of Asia, Walter Russell Mead, a professor at Bard College, suggested that Chinas less than impressive management of the crisis would reinforce a trend for global companies to de-Sinicize their supply chains. The use of the term sick man of Asia in the headline caused particular umbrage and provided a pretext for the expulsion of three Wall Street Journal reporters from China. Chinese Foreign Ministry Spokesperson Geng Shuang condemned the use of racially discriminatory language, to which U.S. Secretary of State Mike Pompeo responded with a defense of the free press.

The rapid politicization of the new coronavirus, and particularly of Chinas role in containing it, has historical precedents. From the bubonic plague at the end of the nineteenth century to HIV/AIDS in the 1990s to SARS in 20023, Western observers have long viewed Chinas responses to epidemic crises as indices of its relative political and economic openness. Chinas management of disease has also been crucial to how Chinese citizens have viewed their nation and how the Chinese state has reaffirmed its authority.

Between 1894 and 1950, an estimated 15 million people died of bubonic plague in a pandemic that began in China. The disease spread from Yunnan, on Chinas southwest border, to the Pearl River Delta, with Hong Kong serving as its global launch pad. Many Western commentators were convinced that the plague germ had incubated in Chinas crowded cities. These critics took the absence of modern sanitation as an indication that the Qing dynasty was incapable of governing. Disease, they concluded, had revealed the political system for what it was: moribund and in need of fundamental reform.

The plaguehit China at a time when rival imperial powers were competing to enlarge their spheres of influence. In 1894, Japan went to war with the Qing over control of the Korean Peninsula. Chinas defeat and its loss of Korea as a vassal state exposed the countrys inability to modernize; the Qing army and navy were simply no match for Japans remodeled forces. Then, in 1899, U.S. Secretary of State John Hay published his Open Door Note, which attempted to create a framework for competing foreign interests in China and protect Chinas recently weakened territorial integrity. But the proliferation of imperial networks and the push to open up Chinas markets had an unintended consequence: they provided the conditions for infections to globalize and a rationale for further foreign intervention in Chinese affairs.

Disease had revealed the political system for what it was: moribund and in need of fundamental reform.

The term sick man of Asia was coined in this postwar context. There was much soul-searching in China as to what had caused the countrys ignominious defeat in the Sino-Japanese War. Many reformers pointed to a pervasive cultural and political malaise, drawing on social evolutionary ideas to emphasize Chinas moral and physical atrophy. Foremost among these critics was the Chinese scholar Yan Fu, an esteemed translator who was educated in the United Kingdom. In On Strength, an article published in a Tianjin newspaper in 1895, he likened China to a sick man in need of radical therapy. The Chinese needed to jettison debilitating habits, including opium smoking and foot-binding. The nation was a living organism locked in a competitive struggle for survival; citizens were the cells that formed this vital whole, so their physical and moral well-being was paramount.

Calls for reform grew louder in the late 1890s. The intellectual Liang Qichao reiterated Yans claim that as a country inhabited by sick people, China was a sick nation. Ground down by an autocratic and incompetent state, the Chinese had become sick not only morally but also physically: rampant diseasesamong them plague, leprosy, tuberculosis, and smallpoxwere sapping the people. Reformers called for restoring the health of Chinas citizenry and rejuvenating the decrepit body politic.

Sickness and health thus provided the basis for justifying reforms that extended from the susceptible Chinese body to the enervated state. In 1923, Sun Yat-senthe first president of the Republic of Chinavisited Hong Kong to give a lecture. Describing his graduation from medical school some 20 years before, Sun told his audience, I saw that it was necessary to give up my profession of healing men and take up my part to cure the country.

A portrait of Yat-Sen in Tiananmen Square in Beijing, China, April2005 Jason Lee / Reuters

Efforts to reform Chinas political and public health would outlast the Qing dynasty and the bubonic plague. In 1910, as Qing rule crumbled, the British-educated, Penang-born physician Wu Lien-teh was sent by the Chinese government to curtail the spread of pneumonic plague across Northeast China. He enacted stringent containment strategies based on modern scientific teachings: postmortems, bacteriological investigations, and mass cremations, to name a few. Wus program was markedly different from the response to the bubonic plague just two decades prior, when endeavors to halt the contagion were left to local charitable organizations or to the foreign officials who staffed the Imperial Maritime Customs Service with minimal oversight from the viceroy at Canton.

Just as before, however, Chinas handling of the outbreak within its borders would have geopolitical implications. During the pneumonic plague outbreak, China, Japan, and Russia vied for political and economic dominance over Manchuria. With Japan rapidly modernizing and Russia bullishly expanding eastward, Chinas management of the disease was an opportunity to showcase its newfound efficiency and reinforce its territorial claims. But reform came too late. In 1911, the Xinhai Revolution overthrew the Qing dynasty. Coincidentally, the springboard for the rebellion was Wuhan, the city that would become the epicenter of the COVID-19 epidemic.

The relative openness of Chinas republican period, from 1911 to 1949characterized by freer markets, a flourishing press, newfound liberties, and lively engagement with the worldwas also reflected in the countrys health sector. Chinese scientists took part in international meetings, new opportunities opened for women in health care, medical schools expanded, and a Ministry of Health was established in 1928, in part to address the rural-urban disparity in health.

That age came to an end with the communist seizure of power, led by Mao Zedong in 1949. Although the Peoples Republic, like previous governments, focused on disease prevention, health, and national strength, it acted upon these concerns altogether differently. The communist government viewed health through a statist lens and as an important rationale for one-party rule. Maos war on disease was a case in point. Ostensibly a health campaign, the war was actually part of an ambitious social program that sought to extract undesirables, promote unity, and fight against capitalist imperialism.

The communist government viewed health through a statist lens and as an important rationale for one-party rule.

During the Korean War, for example, North Korea and the Soviet Union alleged that the United States was using biological weapons to spread infectious diseases. China supported the charges, claiming that U.S. planes were dropping insects and other disease vectors to spread plague, cholera, encephalitis, and anthrax. Mao responded with a Patriotic Hygiene Campaign in 1952, admonishing citizens to root out and destroy invading pests: flies, mosquitoes, rats, fleas, and even dogs. Anti-bacteriological warfare measures were put in place, including quarantine stations. Although the veracity of the biological warfare allegations continues to be debated, compelling evidence suggests that the charges were fabricated as part of a concerted propaganda campaign. The accusations provided the leadership of the Chinese Communist Party with a pretext for pushing a domestic political agenda under the guise of biosecurity.

Mao continued to leverage health as a political tool during the Cultural Revolution, which was initiated in 1966 as a war against bourgeois institutions, including modern medicine. In 1964, Mao had attacked the Ministry of Health as an elite establishment; during the Cultural Revolution, he proceeded to persecute doctors and starve hospitals of support. The Cultural Revolution also created ideal conditions for infectious diseases to flourish. An outbreak of meningitis in Beijing in the late summer and fall of 1966 was soon spread across the country by the student paramilitarythe Red Guardstraveling on the railways. Chinese authorities made no attempt to contain the epidemic, since doing so would have put the brakes on the Cultural Revolution, which depended on the mass mobilization of the Red Guards to purge society of recalcitrant bourgeois elements. The United States offered assistance, which China flatly declined. By the spring of 1967, more than 160,000 people had died.

A Red Guard reenactor in Beijing, China, April 2006 Jason Lee / Reuters

And yet, even as his government cracked down on bourgeois medicine, Mao pursued an antidisease program directed at schistosomiasis, or snail fever, an infectious disease caused by a species of parasitic flatworm. The anti-schistosomiasis campaign involved rallying large numbers of rural workers to laboriously collect and destroy snails in central and southern China. In his poem Farewell to the God of Plague, Mao celebrated the campaigns success with a vision of restoring to life ghostly villages choked with weeds. Ultimately, however, the campaign failed to live up to Maos expectations: schistosomiasis remains endemic in China.

The communist state offloaded its responsibility for health onto the collective. In 1968, the barefoot doctor program became national policy. Villagers were recruited as part-time paramedics and underwent basic health-care training. They were given access to vaccines but otherwise received minimal state support. This putative from-the-ground-up vision of health helped inspire a global shift: in 1978, the countries that gathered at the WHO International Conference on Primary Health Care adopted the Declaration of Alma-Ata, which upheld health as a basic human right and emphasized community-based health care for all. Ironically, this affirmation of Maos legacy took place precisely as his successor, Deng Xiaoping, was introducing economic reforms. Chinas health-care system would be one of the first areas earmarked for change.

Chinas reform era coincided with the rise of new infectious diseases, such as HIV/AIDS. The first indigenous cases of HIV/AIDS in China appeared in Yunnan among heroin users, but by the early years of this century, infection was increasingly sexually transmitted. A booming plasma economy in the 1990s further fueled the epidemic. Third parties paid donors in impoverished rural areas for blood, from which they extracted plasma to sell to biotech companies. The residual blood was then returned to donors. As a cost-saving practice, blood from different donors was often mixed in the same centrifuges. The result was a sharp increase in infectious diseases contracted through cross-contaminated blood. More than one million people in China are estimated to have contracted HIV/AIDS.

The blood contamination scandal set the pattern for future infectious disease crises: rumors of an epidemic, attempts at a cover-up, an expos by a medical whistleblower, followed by an official admission of the problem and draconian containment measures to mitigate the damage. In the case of the plasma scandal, the whistleblower, medical researcher Shuping Wang, brought contamination to the attention of officials in Henan, the worst-affected province. The officials attempted to deny and cover up the crisis, but news soon leaked to the international media. The plasma collection centers were finally closed for rectification in 1996.

The Western media, however, had already portrayed the contamination scandal as illustrative of Chinas poor regulation and endemic corruption. Moreover, the episode exposed the awkward cohabitation of rampant capitalism and authoritarianism in post-Mao China: a toxic mixture of unregulated markets, patchy provincial oversight, and overregulated governance.

A travel checkpoint during the SARS outbreak in Xinjiang, China, May 2003 Alessandro Digaetano / LUZphoto / Redux

Similar concerns about the state greeted a different health crisis in November 2002, when the deadly SARS virus was detected in Guangdong Province. The SARS outbreak also played out on the public stage through leaked information, cover-ups, and crackdowns. Jiang Yanyong, a physician in Beijing, revealed the states efforts to conceal the true number of SARS cases in an interview with The Wall Street Journal. That same day, the reporter Susan Jakes published a searing expos in Time magazine, based on a signed statement by Jiang, under the headline, Beijings SARS Attack. These reports catalyzed a policy U-turn in China. The mayor of Beijing and the minister of public health resigned, and the government embarked on a concerted and much-publicized campaign to contain the epidemic.

SARS was a major test for Chinas leadership. The outbreak threatened to derail Chinas export economy. And at least initially, Beijings bungled response set off a panic that undermined the governments international aspirations. China had joined the World Trade Organization in 2001, and that same year, Beijing was chosen to host the 2008 Summer Olympic Games. Membership in the WTO and hosting the Olympics were both viewed by the Chinese leadership as important platforms for promoting Chinas role as a global player and for ensuring foreign investment. SARS jeopardized that. As Premier Wen Jiabao declared, the health and security of the people, overall state of reform, development, and stability, and Chinas national interest and international image are at stake.

Not surprisingly, many commentators have drawn parallels between SARS and the current epidemic. As with SARS, officials in the province where COVID-19 broke out first downplayed the problem, and the public accused them of a cover-up. The government cracked down on whistleblowers, such as Li Wenliang, a doctor who had tried to share information about the virus. Li was hounded by the police and died of the disease.

Chinese President Xi Jinping has set out to contain the epidemic through a campaign strikingly reminiscent of the one against SARS. The Chinese government has marshaled tens of thousands of health-care workers and military personnel in what Xi has described as a total war. Ding Xiangyang, the deputy secretary-general of the State Council, has called the epidemic a battle for China and a risk to the nation unprecedented since the founding of the Peoples Republic.

This war has challenged Xis authority in some respects, but it has also provided an occasion for Xi to reaffirm his credentials as Maos heir. By emphasizing the scale of the crisis, Xi can affirm his reputation for resourceful and clearheaded leadership when he overcomes it. For the moment, at least, Xis strategy appears to be working, bolstering his support in many parts of China, if not in Hubei Province, where the disease first emerged. As Chinas citizens watch the chaotic scenes of COVID-19 panic across Europe and the United States, Xis response to the virus suddenly looks proportionate.

Paramilitary containing the spread of coronavirus in Beijing, China, March 2020 Carlos Garcia Rawlins / Reuters

Read the rest here:

Past Pandemics Exposed Chinas Weaknesses - Foreign Affairs Magazine

Posted in Germ Warfare | Comments Off on Past Pandemics Exposed Chinas Weaknesses – Foreign Affairs Magazine

State Department marks bioweapons accord with reference to pandemic – Washington Times

Posted: at 5:56 am

The State Department on Thursday hailed the anniversary of an agreement limiting biological weapons by noting the spread of the Wuhan coronavirus pandemic.

Today we observe the 45th anniversary of the #BiologicalWeaponsConvention and reaffirm the importance of #BWC Parties commitments to preventing biological weapons, the Bureau of International Security and Nonproliferation stated in a tweet.

The #Covid-19 pandemic highlights the importance of #BWC Parties commitments to reducing all biological risks, the tweet noted.

The coronavirus outbreak has been traced to Wuhan, China, but details about the exact origin have not been determined. Most virology experts believe it was not engineered as a biological weapon.

Experts have voiced differing views on whether new bat-origin virus mutated naturally to humans from a wild animal market in Wuhan, or may have escaped from a research lab studying coronaviruses.

The Biological Weapons Convention first entered into force on March 26, 1975.

The multilateral convention prohibits the 183 states that are signatories from developing, producing or stockpiling biological and toxin weapons.

The Wuhan virus, known officially as the severe acute respiratory syndrome coronavirus 2, or SARS-CoV-2, first surfaced in Wuhan and has since December spread rapidly throughout the world.

Biological warfare experts say the virus is not an ideal biological weapon because of difficulties of controlling its spread.

The main toxin and biological weapons that are studied by the U.S. military are called the big six by Dr. Mark Kortepeter, a retired Army colonel who is an expert at germ warfare and worked at the Armys Fort Detrick biological warfare defense research lab.

The six are botulism toxin, tularemia, Ebola and other hemorrhagic viruses, plague, smallpox and anthrax.

Each pathogen has unique skills and attack strategies to outmaneuver humans and rain death and destruction on individuals or societies, Dr. Kortepeter wrote in his book Inside the Hot Zone: A Soldier on the Front Lines of Biological Warfare.

The State Department said in its latest annual report on arms control compliance that the United States has compliance concerns with respect to Chinese military medical institutions toxin research and development because of the potential dual-use applications and their potential as a biological threat.

China signed the convention but the report said there is no available information to demonstrate that China took steps to fulfill its treaty obligations to give up its offensive biological weapons program.

The rest is here:

State Department marks bioweapons accord with reference to pandemic - Washington Times

Posted in Germ Warfare | Comments Off on State Department marks bioweapons accord with reference to pandemic – Washington Times

For China and Russia, coronavirus hoaxes are another strain of disinformation warfare – The Globe and Mail

Posted: at 5:56 am

Moscow, March 25: A woman watches a live address to the nation from Russian President Vladimir Putin about the coronavirus pandemic.

KIRILL KUDRYAVTSEV/AFP via Getty Images

Russia and China have launched what experts say are disinformation campaigns against the West, seeking to change the global narrative about where the coronavirus pandemic originated, and which countries are leading the fight against it.

The subplot to the stories Moscow and Beijing are selling is one of Western societies in decline, with authoritarian systems proving themselves superior to democratic ones in managing the crisis.

A report prepared earlier this month for the European Union pointed the finger at both Russia and China for their roles in feeding an infodemic of untrustworthy information about COVID-19.

Story continues below advertisement

State-sponsored disinformation is different from some of the simpler hoaxes being spread online including a lot of bad, or unproven, advice about how to avoid or treat the virus in that it is being spread to advance geopolitical aims.

As of Friday, the European External Action Service, an arm of the EU tasked with combating propaganda, had compiled a list of 162 examples of coronavirus-related disinformation, which it traced to pro-Kremlin media outlets or social-media accounts.

One report on a pro-Kremlin website said those with money had unleashed secret germ warfare on the rest of the world. Another claimed that the pandemic had forced the closing of the metro in the Ukrainian city of Lviv. Lviv does not have a metro.

For Russia, the effort to sow chaos is seen as an extension of the hybrid war an undeclared conflict fought in the military, economic and information spheres that it has been waging against the West since 2014, when Moscows annexation of the Crimean Peninsula from Ukraine made it the target of crippling economic sanctions imposed by Canada, the United States and the European Union. Victory for Moscow means breaking Western solidarity, and bringing the sanctions to an end, while keeping Crimea.

Analysts say Beijings aims are even loftier, with an eye to replacing Washington as the preeminent global power the capital other countries look to for leadership.

Russia would like to see the EU divided, and to pick off some of the countries like Italy, turning them from pro-U.S. to pro-Kremlin, said Agnieszka Legucka, a senior research fellow on Russia at the Polish Institute of International Affairs.

Russia is also transferring Chinese disinformation and propaganda that Western democracies are not able to help and save their people, that only strong countries like Russia and China are able to manage the coronavirus.

Story continues below advertisement

Wuhan, March 10: A screen at a near-empty shopping centre broadcasts Chinese President Xi Jinping's visit to the epicentre of China's COVID-19 epidemic.

Thomas Peter/Reuters

Zhao Lijian, a spokesman for the Chinese foreign ministry, has amplified conspiracy theories on Twitter that the virus was introduced to Wuhan by the U.S. military.

Twitter

A key piece of disinformation spread by both China and Russia and then repeated by friendly governments such as Irans is a baseless accusation that the coronavirus, which originated in December in a seafood and live animal market in the Chinese city of Wuhan, was instead a U.S. military bioweapon gone awry.

In Chinas favoured telling of that story, COVID-19 was actually brought to Wuhan by infected U.S. military personnel who attended the Military World Games in October. That version was given prominence by Zhao Lijian, a spokesman for the Chinese foreign ministry, who retweeted an article published by a Montreal-based website known for propagating conspiracy theories and pro-Russian disinformation.

It might be US army who brought the epidemic to Wuhan. Be transparent! Make public your data! US owe us an explanation! Mr. Zhao wrote in another tweet.

Russian media have pushed out a similar tale with a local twist. REN TV, a channel controlled by Kremlin-friendly businesspeople, carried its own evidence-free report blaming the U.S. government for coronavirus, but switched the point of origin to the U.S.-funded Lugar Research Center in the former Soviet republic of Georgia, a country where Washington and Moscow have spent decades wrestling for influence.

This is propaganda. What can we do? Paata Imnadze, the director of Lugar, told Coda Story, a news website based in the Georgian capital city of Tbilisi. The Lugar lab has actually led the Georgian governments response to the coronavirus pandemic.

Kremlin spokesman Dmitry Peskov has called the EU report on Russian-sponsored coronavirus disinformation unfounded allegations which in the current situation are probably the result of an anti-Russian obsession.

Tehran, March 22: Supreme Leader Ayatollah Ali Khamenei addresses Iranians in a televised speech.

Office of the Iranian Supreme Leader via AP

The unfounded allegations about the U.S. military creating COVID-19 have also been pushed along by Irans Ayatollah Ali Khamenei, who said it was one of the reasons his country could not accept an American offer of help dealing with the crisis.

Youre accused of having created coronavirus. I dont know how true it is. But when theres such an allegation, can a wise man trust you? read a posting on his English-language Twitter account.

Bill Bishop, an expert on Chinese media, said Beijing was equally keen to muddy the waters about the origins of COVID-19, both for domestic political purposes, and to protect the countrys international reputation.

At home, the Communist Party regime had successfully via social-media networks that are tightly controlled by state censors persuaded many Chinese to blame a foreign enemy for the outbreak, rather than their own government.

The fact that an official foreign ministry spokesman helped spread the same disinformation on Twitter (a platform that is blocked inside China), suggests that the effort to push out an alternative narrative about the origins of COVID-19 was directed from the very top.

Zhao Lijian would not be doing this if he didnt believe that he had approval to do this stuff, said Mr. Bishop, who edits the Sinocism e-newsletter, which is popular with China-focused academics. And if you look at how the system works people who censor all the time are not censoring this.

Story continues below advertisement

U.S. President Donald Trump has frequently called COVID-19 a 'Chinese virus' despite advice that this inflames anti-Asian racism.

Twitter

The Chinese effort to rewrite the viruss origin story were partly defensive. Mr. Zhaos inflammatory tweets came two days after U.S. President Donald Trump first retweeted a post referring to COVID-19 as the China Virus. Mr. Trump has since made a point, on Twitter and during televised news conferences, of referring to the disease as the Chinese virus.

Mr. Trump promised this week to stop using such language after a rise in racist attacks targeting Asian-Americans but he made it clear that he believed he was only fighting his corner in a propaganda war. I dont regret it, but they accused us of having done it through our soldiers, they said our soldiers did it on purpose, what kind of a thing is that? he told Fox News on Tuesday.

But a day after Mr. Trump made his promise to stop using the racially charged term, G-7 foreign ministers were unable to agree on a joint statement on the coronavirus outbreak because of a U.S. insistence on including the term Wuhan virus.

Mr. Trump has himself been accused of spreading unproven and unsafe medical ideas by using his press conferences to talk about potential coronavirus remedies that have not yet been tested. However, experts say that his remarks have generally fallen into the category of bad advice, rather than a state-sponsored propaganda campaign.

Belgrade, March 21: Crew members wave Chinese and Serbian flags after medical experts from China arrived with supplies to help the Balkan nation fight the coronavirus.

Marko Djurica/Reuters

Beyond blurring the origin story, Russian and Chinese outlets as well as social-media accounts that reliably parrot them have also sought to give the impression that Moscow and Beijing are leading the world both in terms of managing the pandemic, and in lending a helping hand to others.

China, the country that was hit first and, initially, hardest, is now keen to show that it has the virus under control, with cities such as Beijing and even Wuhan returning to normal as the rates of deaths and new infections slow.

Story continues below advertisement

The Kremlin, meanwhile, had until this week resisted the lockdown measures adopted by many other countries, pointing to its relatively low infection rate, and the fact that only one death in Russia has been officially attributed to coronavirus. That narrative has changed only in the past few days, as the number of infections has shot up, causing President Vladimir Putin to order a one-week work stoppage next week to contain the spread of the virus.

Mr. Putin also indefinitely postponed an April 22 referendum on constitutional changes, which, if the measures pass, would give him the ability to remain in power until 2036.

Maria Snegovaya, a post-doctoral research fellow at Johns Hopkins University who focuses on Russia and Eastern Europe, said the public should be skeptical about both Chinas and Russias versions of the story.

Definitely, we should not trust the data that comes from authoritarian regimes. This is somewhat true about China, and particularly true about Russia, she said, pointing to how the Soviet Union initially denied there had been nuclear disaster at Chernobyl in 1986, and how Mr. Putins own government lied for days about the sinking of the Kursk nuclear submarine in 2001.

Tied into the idea that China and Russia are handling their own coronavirus problems better than the West are their showy donations of medical aid to crisis-stricken Italy and Spain, which have seen the worlds deadliest outbreaks to date.

The way this is portrayed in pro-Russian media is, See, the EU is so weak and the U.S. is unreliable. Only Russia and China are coming to help them, said Ms. Snegovaya. Its a typical [Russian security services] disinformation campaign. Its very convenient that the West is weakened at this moment, so you try to undermine it further.

Story continues below advertisement

But after days of headlines about Russia and China helping where Brussels could not, Italys La Stampa newspaper reported Thursday that 80 per cent of the medical help delivered by Russia, which included disinfection equipment, was useless. Spains Health Ministry, meanwhile, found that test kits donated by China werent sensitive enough to detect most coronavirus cases, and decided to return them.

Sources: GOVERNMENT WEBSITES, UNIVERSITY OF TORONTO AND JOHNS HOPKINS UNIVERSITY

Show all

How many coronavirus cases are there in Canada, by province, and worldwide? The latest maps and charts

Go here to see the original:

For China and Russia, coronavirus hoaxes are another strain of disinformation warfare - The Globe and Mail

Posted in Germ Warfare | Comments Off on For China and Russia, coronavirus hoaxes are another strain of disinformation warfare – The Globe and Mail

Historically Speaking: The flu epidemic we’ve been here before – Roswell Daily Record

Posted: at 5:56 am

By Janice Dunnahoo

Special to the Daily Record

I know by now everyone is getting weary of hearing the word pandemic. It is scary and yes, we are living in a time and place we have never navigated in our lifetimes, but historically, this is not that unusual. I have written about the 1918 Spanish influenza pandemic a couple of years ago, but in doing research I found a bit more, which I would like to share here, just to prove that times do change in some ways, but in others they do not.

Lets start with some Roswell Daily Record articles from the year 1918.

The first one is dated October 25, 1918

Notice To The Public

Whereas the present epidemic of Spanish influenza requires rigid regulations to control and abate it.

Therefore, be it resolved by the Board of Health of the City of Roswell.

1. That all places of business in the City of Roswell, except drugstores, hotels and restaurants, and auto filling stations and garages, be closed during all hours of the day except from 9:00 AM to 4:00 PM, except Saturdays, when they should close at 7:30 PM, and all persons are urged to stay off the streets except when attending to necessary business.

2. Physicians must require patients with colds and running temperature, which in their opinion are incipient influenza cases, to remain at home as long as danger threatens.

3. All persons suffering from this disease are required to remain at home for three days after they cease to run temperature.

4. All physicians are required to report at the home of the City Physician during the morning hours for all additional cases of this disease.

These orders to take effect Monday, October 21, 1918.

Board of Health of the City of Roswell,

By W.C. Buchly, secretary

Another Roswell Daily Record article is dated October 25, 1918.

Warning To The Public

All persons are hereby warned not to congregate upon the streets or in stores or other public places at any time. All people are forbidden to congregate at night upon the streets or in other places after six oclock, and people having business to transact in stores or other places open to the public are hereby requested and directed to go into such places of business, immediately attend to the matter in hand, and at once return to their homes.

By order of the Board of Health of the City of Roswell, this October 12, 1918.

By W.C. Buchly, Secretary

A proclamation was published in the Roswell Daily Record, Oct. 26, 1918 by Governor Washington Ellsworth Lindsey, who was the third governor of New Mexico after it became a state in 1912.

A PROCLAMATION

By The Governor Of The State Of New Mexico

Notwithstanding the continued publication of precautionary advices touching the control of the epidemic of Spanish Influenza in the State of New Mexico, it is apparent daily increase, warrants the exercise of utmost diligence on the part of all our people in the observance of rules and regulations promulgated by competent health authorities designed to curb its progress.

In the absence of an organized system for compulsory health conditions reports in the State, reliance as to such conditions must be had upon the news columns of the public press and other less effective media. The volume of information thus accumulated relative to the epidemic intensity, universal spread and high percentage of fatality of this disease should alarm every citizen to combative repressive action.

While several municipalities in the State have published and are enforcing repressive regulations very effectively, not state wide suggestion has yet gone forth.

NOW THEREFORE, I, W.E. LINDSEY, GOVERNOR OF THE STATE OF NEW MEXICO, in the interest of the public health welfare and the war work of the people of this state do urgently request the discontinuance of all pending court sessions in the State; the adjournment of the public schools, the isolation or quarantine of all collegiate Institutions; penal and charitable institutions; the discontinuance of all church and other public assembly; the avoidance of unnecessary burial attendance and services; the prevention of the group assemblage of children in homes.

I further urgently request that all the people give strict observance to instructions relative to prevention of infection and the proper care and treatment of those attacked.

I respectfully but urgently call upon on the police authorities of the state to actively aid in the enforcement of all health laws and regulations and to urge the observance of the requests enumerated in this proclamation as well as the observance of all other proper and necessary precautionary and remedial measures.

IN WITNESS WHEREOF, I have hereunto set my hand and caused the Great Seal of the State of New Mexico to be affixed. I one at the City of Santa Fe, this the 17th day of October, 1918 A.D., 1918.

W.E.LINDSEY,

ATTESTED: Antonio Lucero

Following is a segment Dr. Elvis Fleming wrote on the epidemic:

The flu epidemic of 1918-19

The annual flu season always seems to elicit discussions about the worldwide flu epidemic of 1918-19, in which deaths attributed to the disease are estimated at some 20 million.

More than 500,000 Americans died during the epidemic, which is more than the deaths in both world wars, the Korean War and the Vietnam War combined. The flu was no respecter of people. No matter whatones station in life, place of residence, or any other factor, no one was assured of eluding the dreaded disease.

More than 1,000 New Mexicans perished in the flu epidemic, according to an article in the Valencia County News-Bulletin published on Nov. 25, 1998, by Richard Melzer and Oswald Baca. The writers observed, Much of the epidemic remains a mystery to this very day. Not even its name, The Spanish Flu, is understood because the epidemic did not originate in Spain or any other Spanish community. Evidence points to its origin in March 1918 at an Army camp in Fort Riley, Kansas, from which it spread in two terrible waves around the world.

Some people felt sure the epidemic was caused by germ warfare launched by the Germans during the final stages of World War I, according to Melzer and Baca. The leading evangelist of the times, Billy Sunday, proclaimed that the epidemic was the wrath of God against a sinful generation.

Vital statistics for the city of Roswell show that 92 people died of influenza, influenza pneumonia and pneumonia between Oct. 12, 1918, and March 10, 1919. The deaths were spread out over the six-month period, with 52 coming in October, 15 in November, 16 in December, seven in January and only one each in February and March. These numbers show, as Professor Melzer puts it, that the epidemic hit with incredible force in the last days of the First World War, showing no mercy to a world already ravaged by four years of violence and death.

Most of the Roswell deaths took place at home, but 36 percent of them were at St. Marys Hospital. Eight patients of Dr. C.M. Yater died at his sanitarium at 310 North Richardson Ave. Yaters ad in the city directory stated: Medical and Surgical; special facilities for the care of confinement cases, including a perfectly equipped confinement room. All on the ground floor.

Strangely, the ad also claims, No contagious diseases admitted.

Thirteen other doctors also lost patients, the largest number being the 21 patients of Dr. W.C. Buchley. Dr. J.B. Keister lost 12; Dr. Eugene M. Fisher lost 10; and Dr. W.W. Phillips and Dr. Yater lost eight each. Dr. W.E. Goodsell and Dr. J.E. Crawford each had seven patients deaths; while Dr. David H. Galloway lost six; Dr. C.T. McClane lost four; Dr. W.T. Joyner lost three; and Dr. J.J. Walker lost two. Dr. C.L. Parsons, Dr. Charles F. Beeson and city physician and health officer Dr. R.L. Bradley each lost one patient.

A local doctor who was also mayor of Roswell at the time also succumbed to this flu. A note from his obituary dated October 14, 1918 reads as follows:

Dr. C.F. Montgomery, the mayor of the city and also one of Roswells finest types of manhood passed away today. In his passing the city and the state loses one of its most capable and conscientious workers as well as a perfect gentleman.

The demographics of the victims show that 54 percent were male, two thirds were Anglo and one third were Mexican. No other ethnic groups are listed. None of the victims were more than 70 years old, and only five were between 57 and 70. All the others were under 50. Most of them were in their late 20s and early 30s. The age categories were as follows: 36-50, 11 deaths; 16-25, 17 deaths; 6-15, 10 deaths; 0-6, 11 deaths. Eight of those under six were infants. (Totals do not add up to 92 deaths because some of the information is not available on some of the victims.)

The occupations most frequently listed for the victims were housewife, 10; rancher, five; farmer, two; bookkeeper, two; New Mexico Military Institute cadets, five; and other students, two. Several other occupations were listed once, including a doctor and a teacher.

In an interview in February 1975, Colonel E.L. Lusk, one-time high school principal at New Mexico Military Institute, remembered that the commandant, Captain H.P. Saunders Jr., took it first. Lusk came down with it about three days later and was sick for a week. The hospital was full, so many of the cadets who were ill with the flu could not be admitted.

Some of the faculty took cadets into their homes to nurse them back to health. About the time Lusk got over his affliction, Capt. R.G. Breland, the English instructor, took it. Luskbrought Breland to his house where Mrs. Lusk attended him for about a week. Then Mrs. Lusk took down with it herself.

Thus, World War I ended in Roswell and the United States.

To paraphrase Melzer and Baca: The epidemic took the lives of innocent people who lived thousands of miles from any battlefield of the war, but they had no protection from an enemy so minuscule that they could not see it even with the most powerful microscope of the time.

Following is a remedy of the day, I thought it would be fun to include. Dont try this at home:

Cough medicine

The following is a recipe for cough medicine that will give relief when all others fail; 1/2 pint flax seed, two quarts water, juice of six lemons, one pound honey, 1/2 pound sugar, 1/2 pint good whiskey. Boil the water and the flaxseed together for a few minutes, strain and add lemon juice, honey and sugar. Boil this mixture a few minutes until well mixed. When it is cool add the whiskey, which is to preserve it. Half of this recipe makes two large bottles full.

Janice Dunnahoo is chief archivist at the Historical Society for Southeast New Mexico Archives. She can be reached at 575-622-1176 or at jdunna@hotmail.com.

Read this article:

Historically Speaking: The flu epidemic we've been here before - Roswell Daily Record

Posted in Germ Warfare | Comments Off on Historically Speaking: The flu epidemic we’ve been here before – Roswell Daily Record

Coronavirus: How Orania has been affected by the disease – The South African

Posted: at 5:56 am

As we sit within the confines of our homes, lockdown is making us yearn for the gift of time travel. What wed give to go back just by a few months before our fears and anxieties regarding coronavirus manifested themselves. Well, the folks of Orania have managed it because theyre living outside of the 21st century.

The whites-only Afrikaner enclave in the Northern Cape acts as its own entity. Turning its back on South Africas democratic project as apartheid came to an end, the clutch of citizens who still live in the town an estimated 2 000 to 3 000 still pay homage to the system that was labelled a crime against humanity.

But where, exactly, do they stand on the current coronavirus crisis? Are they following the rule of the land which engulfs and dwarfs their humble landscape, or do they simply follow their own advice? Well, in contrast to certain other policies in Orania, its not actually that black and white.

We know that they are observing social distancing, and theyve been taking quarantine measures since the middle of March. Local sewing groups have stitched together masks that people are being asked to wear during the coronavirus crisis. They may have self-isolated from South Africa since the early 1990s, but theyre leaving nothing to chance in the face of a global pandemic.

Not many people leave Orania, and even fewer visit. Their base in the Northern Cape is one of the most remote in the land. But, playing it safe is very much the mantra here. They have even manufactured some of their own hand sanitizers, treating the gravity of the situation with the respect it deserves.

They have published their own set of hygiene guidelines, very similar to those issued by the South African government. An emergency command centre made up of the town board provides regular updates on their preparedness to deal with coronavirus, and how the situation outside of their compound is developing. Gawie Snyman, Ronald Bain, Harry Theron and Frans de Klerk are named as the information-givers.

Those who have shut themselves away on ideological grounds, fearing an outside threat, perhaps never thought the biggest battle of their lives would be related to germ warfare. The communities within communities such as elderly care facilities also receive visits from singers and performers to lift their spirits during times of isolation.

Virtual braais and radio-streamed concerts make up for the lack of open-air activities on offer to the inhabitants of Orania. It hasnt been all fun and games, though. The idyllic image this settlement likes to portray against the backdrop of its controversial origins suffered a slight wobble last week.

A statement shared on the towns official Facebook page stated that one resident of Orania was showing symptoms of coronavirus. Its claimed that they were privately tested while receiving medical treatment. The test came back negative. But the fear factor of COVID-19 remains in place.

An image showing a warehouse full of toilet paper unapologetically boasts about having one of South Africas most treasured commodoties by the pallet-full. Indeed, this desperation to prove something to the rest of the country runs deep.

A local community group posted this message on their social media channels over the weekend Kim Jong-Un would be proud of this purposeful propaganda:

The SAPS came to visit in Orania yesterday to check that everything is in order. Thanks to Oranians discipline, they found nothing that upset them. After the visit, Colonel Jooste said: Thank you to the residents of Hopetown and Orania for your obedience. It goes bad in other towns and cities in the country. I love you all and I dont want you to die.

Work continues in the town: Binmen are seen wearing full hazmat suits and masks, whereas families are now learning how to cope with homeschooling. Pieter Krige, a community leader in this enclave, posts a photo of his two children beavering away at their studies.

It still remains anyones guess as to when normal life resumes both within the gates of Orania and beyond despite our tentative end-of-lockdown date of Thursday 16 April.

Social distancing has always been Oranias thing but they are now faced with keeping themselves apart from each other, without having a say in the matter. Its not business as usual here, nor is it anywhere in the world. And thats perhaps a source of great humility for this unique, often-maligned town.

As much as Orania has tried to isolate itself, the world is too big of a place to stay shut-off from. Society isnt exactly something you can opt in or out of. The looming threat of coronavirus casts a shadow over this region, and although it may only strengthen their resolve to hunker down and keep themselves in exile, one fact is inescapable: The enemy is not, and never will be, your fellow South African.

Read this article:

Coronavirus: How Orania has been affected by the disease - The South African

Posted in Germ Warfare | Comments Off on Coronavirus: How Orania has been affected by the disease – The South African

CRISPR gene editing could yield drought-tolerant tomatoes and kiwis that grow in salty soil – Genetic Literacy Project

Posted: at 5:55 am

Genetic engineering will allow the production of tomatoes and kiwis that are more tolerant to saline lands and will require less water. The initiative will also develop biostimulants directly applicable to plants to make them more tolerant to stress caused by drought and salinity .

Agriculture has been one of the activities hardest hit by climate change. Figures in this regard indicate that around 40% of the worlds land area corresponds to land affected by drought, a value that could increase to 50% between now and 2025.

One of the initial focuses of the project is to generate new varieties of tomatoes and kiwis using the CRISPR / Cas9 genetic engineering technique. In the case of tomato, the characteristics of Poncho Negro, a Chilean variety originating in the Azapa Valley that has high resistance to salinity and the effect of heavy metals, will be studied.

Components to improve tomato 7742 (seminis), the most widely produced and marketed variety in Chile, will also be investigated. Regarding kiwis, the aim will be to increase tolerance to salinity and drought of varieties used as rootstocks, to improve the productivity of Hayward commercial kiwi plants; the third most exported in Chile.

[Editors note: This article was published in Spanish and has been translated and edited for clarity.]

Read the original post

Read more:
CRISPR gene editing could yield drought-tolerant tomatoes and kiwis that grow in salty soil - Genetic Literacy Project

Posted in Genetic Engineering | Comments Off on CRISPR gene editing could yield drought-tolerant tomatoes and kiwis that grow in salty soil – Genetic Literacy Project

How the novel coronavirus is mutating, and if you should be concerned – ThePrint

Posted: at 5:55 am

Text Size:A- A+

Bengaluru/New Delhi: As the coronavirus outbreak continues to spread across the world, the cyberspace has been abuzz with claims that the Covid-19 strain in India is a less virulent mutation than the one travelling abroad. BJP leader and Rajya Sabha MP Subramanian Swamy and gastroenterologist D. Nageshwar Reddy are among those who have made such claims.

While Swamy quoted an American friend in a tweet last week to say the Covid-19 strain in India can be defeated more effectively by our bodys natural defense mechanism than the strains abroad, Reddy in an interview floated similar claims without quoting any research.

Some users responded to Swamys tweet posting a link to a study that they claimed supported his notion. But this study, which is yet to be peer reviewed, has faults of its own, including use of limited data.

A number of experts in the field have termed such assertions baseless. Dr Gagandeep Kang, executive director at the Translational Health Science & Technology Institute in Faridabad, called Reddys comments appalling & misleading.

As such claims circulate online, ThePrint highlights the science of virus mutation and whether you should be worried.

Also read:WHO says coronavirus outbreak in Europe could be approaching peak

The overarching problem is the use of the term Indian SARS-CoV-2 strain that is in itself misleading.

A strain is a sub-type of a virus, characterised by different cell surface proteins, eliciting a different immune response from other strains. A mutation, however, is very minor genetic errors in genome sequences made during replication that doesnt fundamentally change the nature or behaviour of the virus.

So far, only two isolates from India have been genetically sequenced. Both are from coronavirus patients in Kerala who had arrived from Chinas Wuhan in late January. The strains are nearly identical to the ones sequenced in Wuhan and cannot be identified as a separate Indian strain.

Anu Raghunathan, a scientist at the Council of Scientific and Industrial Researchs (CSIR) National Chemical Laboratory in Pune, told ThePrint that the researchers of the aforementioned study used computational biology to analyse the genomic data from different strains around the world.

Theinitial attempt of the team from the International Centre for Genetic Engineering and Biology, New Delhi, at analysing the virus strain is not sufficient to conclude that all Indian strains would have only one unique mutation, said Raghunathan.

The mutations themselves are composed of changes in base pairs.

The novel coronaviruss genome is made up of 30,000 base pairs, while a human genome contains over 3 million. The small numbers make it easy for scientists to track changes and new lineages as they evolve.

To understand what these mutations mean for India, the country will have to sequence a much larger set of the viral isolates from the patients here.

Rakesh K. Mishra, director of CSIRs Centre for Cellular and Molecular Biology in Hyderabad, told ThePrint that his institute has the capacity to run the genome sequencing of the isolates from at least 500 people within a couple of weeks. This can help scientists decide the correct course of action for treating the disease.

For example, if a virus mutates too fast, vaccines being developed now will potentially become useless, and pharmaceuticals will have to constantly keep up with the mutations by developing new vaccines all the time, a financially unviable prospect.

Also read:China now wants people to shop, eat out while rest of the world locks down

Regularly switching up the genetic code is an essential part of how a virus evolves. Some viruses, such as the coronaviruses that cause flu, change their genetic code extremely rapidly. This is the main reason why its so difficult to find a vaccine for coronaviruses. They evolve quickly, making vaccines defunct.

The flu vaccine, now available and recommended especially for older people, needs to be taken annually for this reason. By the time the next season comes along, the vaccine is no longer effective on the circulating form of the virus.

Coronaviruses are ribonucleic acid (RNA) viruses, containing just RNA strands (single or double) as its genetic material. They have about 26,000 to 32,000 bases or RNA letters in their length.

RNA viruses mutate continuously. Such a mutation is what made SARS-CoV-2s jump from animals to humans possible.

The virus multiplies inside living organisms cells by creating copies for the RNA. However, the process it uses to make these copies is not perfect, and often introduces tiny errors in the sequence of letters much like a game of Chinese whispers.

The errors that do not help the survival of the virus eventually get eliminated, while other mutations get embedded. It is these mistakes that help scientists track how the virus travelled around different geographic locations.

For example, by genetically sequencing over 2,000 isolates of samples from different countries, scientists tracked how the novel coronavirusspread to different countries, and how the virus evolved and geographically mutated in different areas.

The word mutations often conjures images of humans with superpowers thanks to Hollywood movies but it doesnt mean the virus acquires superpowers. The genetic changes are normal in the evolution of the virus. In some cases, the changes are extremely rapid because the replication is not rigorous or thorough.

The only problem with mutations is the problem of development of vaccines, which would require constant upgrade.

Also read:Why asymptomatic coronavirus carriers arent as contagious but still a big danger

The novel coronavirus, unlike its cousins, mutates slowly. It seems to have a proofreading mechanism in place that reduces the error rate and slows down the speed of mutation. But the mutations are completely random.

One mutation that supports the virus replication and transmission from human to human or any other host sustains whereas the virus that cannot infect many eventually dies out, explained Shweta Chelluboina, clinical virologist at the Interactive Research School for Health Affairs in Pune.

These are random events and such a phenomenon has caused the outbreak in the first place.The newcoronavirushad mutated successfully enoughthat it jumped from animal tohuman, allowingit to infect manywith still no containment in sight, said Chelluboina.

There were reports earlier about how the novel coronavirus has mutated into two strains so far the original S-type which originated in Wuhan, and the subsequent L-type that evolved from the S-type and is more prevalent in countries like the US. Scientists at the Peking Universitys School of Life Sciences and the Institut Pasteur of Shanghai announced these findings.

The L-type is the more aggressive one, and spreads rapidly but is no more or less virulent than the S-type. The researchers urged everyone to take preventive measures because the mutation indicates that more could be coming.

But these arent really two strains as such. A strain is a genetic variant characterised by different forms of surface proteins. But the L-type and the S-type are not quite different enough to call them strains just yet. They are just mutations, referred to as types, according to the study.

To explain the lower population of S-type, the authors of the study suggested that human-adopted measures of curbing contact contained the S-type to the Wuhan region, and allowed the L-type to spread elsewhere uncontained. While the S-type emerged around the time the virus jumped from animals to humans, the L-type emerged soon after that within humans, the team suggested.

Experts think there is also a definite sampling bias for the L-type, which was just sampled more, and uniformly, resulting in higher representation. The mutations were discovered in a preliminary study, as cautioned by the authors as well, and was performed on a limited population of 103 samples.

The study is not peer-reviewed yet, and as most Covid-related studies are under the open community, is a pre-print for now. It was uploaded on 4 March.

These findings strongly support an urgent need for further immediate, comprehensive studies that combine genomic data, epidemiological data, and chart records of the clinical symptoms of patients with coronavirus disease 2019 (Covid-19), said the study.

The science is evolving rapidly, as more and more genome data is collected from around the world.

Newer research data gathered from genetic sequences uploaded to open source website NextStrain.org indicate that anywhere from eight to 18 different sequences of the coronavirus are making their way around the globe, according to researchers who have genetically sequenced over 1,400 isolates from around the world. These are extremely tiny differences within the viruses in their nucleotide sequences, and none of the sequenced groups seem to be growing any more or less lethal than others.

Most importantly, none of them are new strains despite their coverage as such in the mediaand subsequent clarifications by Nextstrain, who have the data for 2,243 SARS-CoV-2 genomes, of which 1,150 have minor mutations.

On Nextstrain, nearly every virus reveals a slightly different genome. But there are very few mutations and none are strong or vital enough to affect the way the virus spreads, attacks, or lives. The sequences are all named by location where they were first sequenced.

It is very common that during an outbreak, especially during a global pandemic, the genome sequence of earlier isolates from one particular geographical location will differ from that of the later isolates collected elsewhere, said Sreejith Rajasekharan, virologist and post doc at the International Center for Genetic Engineering and Biotechnology (ICGEB) in Trieste, Italy, over an email.

This is what is observed in the current pandemic as well. The first sequence collected from positive patients in Rome, Italy was from a Chinese tourist. This and the one collected after, from an Italian citizen returning from China resemble those that were isolated in China, said Rajasekharan.

However, the ones isolated later in Lombardia and Friuli Venezia Giulia regions (in Italy) match the European clad and not the one from China.

The mutations in the virus are like moving targets, which cant be hit because they keep changing their genetic sequence.

Genome sequencing on a large scale can tell us whether viral isolates are different in different countries from what we saw from China. So this will help us decide whether the treatments being contemplated in those places will be applicable for our strains or not, Rakesh Mishra said.

It will also help decide if the different strains vary so much that developing vaccines may not be viable, Mishra said.

Some behaviours are unique in different strains like how we know that aged people are at high risk but we saw in India young people have also died, said Chelluboina. Some variations in the virus cause the virus to behave in a certain way.

The sequencing will provide a fundamental understanding of how to address the problem without it, the treatments are based on what is known of other viruses which may or may not work for the novel coronavirus, and also likely take up a long time.

That is why it is important to understand the sequence of the virus in local infections to know which countries have a similar virus, so that we can attempt to better predict the outcome, added Chelluboina.

However, Rajasekharan added, The general public needs not be concerned in this regard as the genome of SARS-CoV-2 is quite stable, and therefore the rate of mutation is low.

The novel coronavirus will continue to mutate and pose a challenge to researchers developing a vaccine. Nonetheless, the idea of viruses mutating is not something that needs to worry people in terms of their health when it comes to Covid-19.

Also read:Seasonal flu far more common than coronavirus, but its vaccine is not popular in India

ThePrint is now on Telegram. For the best reports & opinion on politics, governance and more, subscribe to ThePrint on Telegram.

Subscribe to our YouTube channel.

Read more:
How the novel coronavirus is mutating, and if you should be concerned - ThePrint

Posted in Genetic Engineering | Comments Off on How the novel coronavirus is mutating, and if you should be concerned – ThePrint

India What we know about the genome of the virus in India A mutation unique to – Times of India

Posted: at 5:55 am

A virus spreads by replicating itself each time it replicates, it could change a little. Mapping the genome of each changed form of the virus, therefore, helps track where it came from and how. The Translational Bioinformatics Group at the International Centre for Genetic Engineering & Biotechnology in New Delhi studied the genomes of the virus from five locations Wuhan, India , Nepal, Italy and the US to identify what is unique to the novel coronavirus and what difference geographical location makes. A country-specific mutation would explain the severity of illness, the extent and timing of exposure to symptomatic carriers and, consequently, hold the clue to a containment strategy. For instance, the study found the presence of unique mutations identified in the genome from Italy are responsible for the sudden upsurge in the number of affected cases and deaths, combined with other factors a speculation which may be verified with more evidence. Any strategy to counter the virus, then, would have to factor this in.Mutations help viruses survive in hosts and influence its virulence (how it attaches, infects and multiplies in a host). The mutations could be favourable or detrimental to the viruses, depending on the type of mutation. If a mutation results in a more virulent virus, its transmission is enhanced, Dr Dinesh Gupta, group leader of the study which published its preliminary findings in a preprint paper, told TOI.

Mutations help viruses survive in hosts and influence its virulence (how it attaches, infects and multiplies in a host). The mutations could be favourable or detrimental to the viruses, depending on the type of mutation

So what did they find? In the samples the group studied, the sequence from Nepal showed no variation at all. And the maximum mutations were seen in the Indian sequence, six. Mutations bring about variations in viral genomes as the virus evolves to survive in its host. A mutation may be good or bad. Very fast mutations produce viruses which are not able to survive. The viruses that do survive, adapt and transmit are the ones that are sequenced and analysed, Dr Gupta said.

Of the six mutations in Indian genome, only one was unique to India

Mutations in Indian genome

Spike surface glycoprotein (unique to India): A virus protein which helps a virus attach itself to a host cell and enter it

ORF1ab: Polyprotein which is cleaved to form 16 smaller proteins, each known as non-structural protein (Nsp)

Nsp2: Believed to hamper signalling process in host cell

Nsp3: Protein which breaks down other proteins

Helicase or Nsp12, unwinds DNA molecules

ORF8 protein: Helps virus in human adaptation

For specific conclusions, however, Dr Gupta said, a wider base of study would be needed. The current data of just two sequences from Indian samples is too small to make a definitive statement, and requires more sequences to be analysed. He also clarified that one finding of the preliminary report that the microRNA hsa-miR-27b (small RNA molecules that can influence the expression of virus proteins) was found to have a target only in the Indian genome in the first study could not be replicated. We didn't find any target for the miRNA hsa-miR-27b in the second sequence, whereas the miRNA was predicted to uniquely target the spike glycoprotein in the first sequence, he said.

Read the rest here:
India What we know about the genome of the virus in India A mutation unique to - Times of India

Posted in Genetic Engineering | Comments Off on India What we know about the genome of the virus in India A mutation unique to – Times of India

Why can’t we have a COVID-19 vaccine right now? – OnCubaNews

Posted: at 5:55 am

What is a vaccine?

According to the World Health Organization (WHO) a vaccine is understood to be any preparation intended to generate immunity against a disease by stimulating the production of antibodies. This may be, for example, a suspension of killed or attenuated microorganisms, or products or derivatives of microorganisms. Most vaccines are given by an injection, but some are given orally (by mouth) or sprayed into the nose.

In a previous article we had talked about the immune system, which is like the bodys defense army. One is born with a capacity to respond to what the body recognizes as foreign, as a threat (such as a virus, a bacterium, a fungus, or a parasite). That primary responsiveness is quick, but it is not specific and, therefore, sometimes not enough, the threat manages to get past that barrier. We call that first, fast and nonspecific immunity innate immunity.

The body has another way of defending itself, specially designed for each type of threat. Lets say that the body has, from birth, a group of cells ready to design and produce specific weapons for each pathogen. This second army works on what we call acquired immunity.

Since there is a wide variety of pathogens, [1] these cells do not produce these specific weapons until the pathogen enters the body, they recognize it, and they can design exactly the weapon that will harm it. This response is more specific, but it takes longer to start working.

One of the most powerful weapons in this army are the antibodies (also known as immunoglobulins). Antibodies are molecules (glycoproteins) that synthesize cells of the immune system (lymphocytes), these antibodies are synthesized with the exact composition that allows it to specifically (very specifically) bind to a part of the pathogen.

Antibodies have two main functions: they mark these pathogens to be attacked and eliminated by other cells of the immune system, or they bind to a specific part of the pathogen that blocks its ability to enter and harm cells in the body.

Antibodies are generated against specific substances of the pathogens; these substances are called antigens. They are that part of the pathogen that, by interacting with the cells of the immune system, provokes the immune response, which is why identifying them is an important part in the production of vaccines.

Once this army that participates in acquired immunity, designs this production line against a specific pathogen, it already leaves it there programmed (immunological memory), so if this pathogen attacks us again all these specific weapons are ready, the response is faster, if you get sick it is usually much less serious, and many times you do not get sick because the immune system of your body fought the threat and eliminated it before it could harm you and cause symptoms.

Thats what a vaccine does, getting in contact with the pathogen (or parts of it), in a safe (non-disease-causing) way, but enough to trigger your immune response and leave all your weapons ready so if that pathogen attacks you naturally, your response is quick, specific and protective.

What types of vaccine are there?

There are different types of vaccines. Some of them contain the complete infectious agent (live attenuated vaccines and inactivated or dead vaccines). In live attenuated vaccines, an attenuated or weakened form of the disease-causing pathogen (such as chickenpox or smallpox vaccines) is used. So that it elicits a very strong immune response, most of these vaccines need a single dose to immunize you for life. However, when using an attenuated form of the pathogen it should be used with caution in people with weakened immune systems, and it has specificities for its preservation (they should always be kept cold).

Inactivated vaccines use the inactivated version of the pathogen (for example, against polio or rabies). They use a harmless version of the pathogen, but usually do not provide an immunity as strong as live vaccines, which is why multiple doses are often required.

On the other hand, vaccines with toxoids (against diphtheria and tetanus, for example) are those that use the toxins (toxic substances) released by the pathogen when they are the cause of the disease. It generates immunity against this harmful toxin, not against the pathogen itself.

There is another group of vaccines with greater biotechnological complexity: conjugate and recombinant vaccines. These employ fragments of the pathogens molecular structure, which elicit a protective immune response, which is the goal of all vaccines.

They are very safe vaccines, that can be used in anyone and offer a very strong immune response directed at key parts of the pathogen. Conjugates combine these parts of the infectious agent (virus or bacteria) with other molecules that increase their immunogenic capacity (for example, vaccines against some meningococci and pneumococci), while recombinants (such as vaccines against hepatitis B, human papilloma virus or herpes zoster) involves introducing into any vectorit is usually a virus or bacterium that does not cause diseaseregions of the pathogen that we know to be immunogenic; that is, they have the capacity to activate the immune system.

Among the novel techniques being used for the production of vaccines are DNA vaccines, nanoparticle vaccines, among others.

Those involving genetic engineering, the so-called DNA vaccines, have had a major boost with technological development that has succeeded in sequencing (knowing the genetic information) of many pathogens very quickly. The sequence of the current coronavirus, for example, was obtained in just days. Researchers use an organisms genome (its genetic information) to extract the genes that are most likely to match known antigens that could be used in a vaccine.

Once identified, those genes can be combined and inserted into a different, rapidly multiplying organism, such as yeast, to produce experimental antigens, which are then studied to determine their ability to elicit a protective immune response. This method is known as reverse vaccination; no licensed vaccine has yet been released, but several experimental vaccines are already being studied, some of which are in the later stages of clinical trial (for example, a group B meningococcal vaccine). [2] Several of the vaccine candidates against COVID-19 follow this method.

What process does a vaccine candidate have to follow until it is approved for use in humans?

The creation of a vaccine is a long and complex process that often takes 10 to 15 years, and involves the combined participation of governments, and public and private organizations.

The World Health Organization establishes a protocol that many governments and regulatory institutions in the world follow, although each of them has specific regulations.

Ensuring that vaccines are safe, effective and of quality is a crucial element in their development and distribution. It begins with the first phases of the vaccine, generally in the laboratory, where its components are subjected to tests to determine aspects such as purity and potency. The clinical trials consisting of three phases are then commenced.

The license, or authorization for use in humans is the fundamental step in the process. The official entity that grants the authorization, the national regulatory body is the arbitrator that decides whether the established standards have been met to guarantee the quality of the vaccine.

What are the steps that have to be followed?

Exploration stage

This stage involves basic laboratory research, and often lasts 2 to 4 years.

Preclinical stage

Preclinical studies use tissue culture or cell culture systems and animal testing to assess the safety of the candidate vaccine and its ability to elicit an immune response.

Researchers can tailor the candidate vaccine during the preclinical phase to try to make it more effective. They can also perform exposure studies on animals, which means animals are vaccinated and then they try to infect them with the target pathogen; these types of studies are never performed on humans.

Many candidate vaccines do not go beyond this stage, as they cannot elicit the desired immune response. Often the preclinical stages last 1 to 2 years.

To continue the studies, after completing this phase, an application must have been approved by a competent agency.

Human clinical studies

Phase I

This first attempt to evaluate the candidate vaccine in humans involves a small group of adults, generally between 20 to 80. If the vaccine is aimed at children, the researchers will first test it in adults, and will gradually reduce the age of the test subjects until they reach the target. The goals of phase I trials are to assess the safety of the candidate vaccine and to determine the type and extent of the immune response that the vaccine elicits.

Phase II

A larger group of several hundred people participates in phase II testing. Some of the people may belong to groups at risk of contracting the disease; the trials are randomized and well controlled, and include a placebo group. The goals of phase II trials are to study the candidate vaccine for its safety, immunogenicity, proposed doses, vaccination schedule, and method of application.

Phase III

Candidate vaccines that are successful in phase II advance to larger trials, involving thousands to tens of thousands of persons. Phase III trials are randomized and double-blind, and involve the experimental vaccine that is tested against a placebo (the placebo may be a saline solution, a vaccine for another disease, or some other substance). One of phase IIIs goals is to evaluate the safety of the vaccine in a large group of persons. Some unusual side effects may not be apparent in smaller groups of people who were part of the previous phases.

During these phases, the efficacy of the vaccine to protect against the disease is assessed. Tests are done that have to do with the production of antibodies and the immune response of the persons who receive the vaccine. After a phase III trial is successful, accredited agencies will inspect the product, the factories and research results, until approval is issued.

After approved for large-scale use, the vaccines continue to be monitored.

Structure of the SARS-Cov-2 coronavirus

SARS-COV-2 is an enveloped, RNA-positive virus. The key to enter the cell is found in the so-called spike proteins (S), which cover the virus envelope.

SARS-CoV-2 coronavirus vaccines and treatments

The process to start a vaccine can take many years, however, we are told that probably in just over a year we can have a vaccine against this new virus. A response that, if possible, would be of a speed never seen before against a new disease.

This is mainly due to advances in the biotechnology sector. First of all, just one week after China reported the first cases of severe pneumonia of unknown origin to the WHO, the causative agentthe new SARS-CoV-2 coronaviruswas identified. A few days later its genome was already available. In just under three months, more than 970 scientific articles are available in the PubMed database.

Knowing the biology of the virus facilitates the design of therapeutic (antiviral) and preventive (vaccines) strategies. The similarity of genetic information with another coronavirus that has been studied for years, SARS-Cov, which caused the epidemic of acute respiratory syndrome (SARS) in 2002, has led to rapid progress in the pre-clinical phases.

In just these three months there are already several therapeutic proposals and vaccine candidates against the new coronavirus. Science has never advanced so far in such a short time to combat an epidemic. Many of the proposals come from research groups that have spent years working against other viruses, especially against SARS and MERS. This accumulated knowledge has now made it possible to go at a speed never seen before.

Antiviral therapies

Some already available antiviral drugs have been tested to see if they can be effective in fighting COVID-19. Chloroquine, which has been used for years against malaria, is being studied by a group of researchers, as it could reduce the viral load by blocking the virus from entering cells. Some anti-inflammatories, such as barcitinib and mesmosate from camostat (Japan), are being used in some protocols because they could block the entry of the virus into lung cells.

One of the most promising antivirals against SARS-CoV-2 is remdesivir, an inhibitor that prevents the virus from multiplying within the cell. It has already been used against SARS and MERS and has been successfully tested in the latest Ebola epidemics, and against other viruses with the RNA genome. It is, therefore, a broad-spectrum antiviral. At least twelve phase II clinical trials are already underway in China and the U.S., and another has started in phase III with 1,000 patients in Asia.

In the United States, in New York, the FDA has approved the use of plasma from sick patients who have recovered. This involves obtaining blood from donors who have recovered from COVID-19, and isolating the plasma (where the antibodies are located), to transfuse it to sick people. It is not a new treatment; it was used in the Spanish Flu pandemic in 1918. According to the journal Nature, this effort in the United States is following preliminary studies carried out in China. The convalescent plasma approach has also had modest success during previous outbreaks of severe acute respiratory syndrome (SARS) and Ebola. It could be an emergency response in which more effective treatments appear.

There are at least 27 clinical trials with different combinations of antiviral treatments such as Interferon Alfa-2B, ribavirin, methylprednisolone, and azvudine. At the moment they are experimental treatments, but they are a hope for the most serious and severe cases.

COVID-19 vaccines for the future

The main hope for controlling the disease is based on achieving effective vaccines. The WHO, until March 20, had a list of 41 candidates, but based on press reports from various countries, we know that more are being worked on.

An article published on March 23 by The Conversation summarizes some of the most promising projects.

In clinical trial phase

According to the publication, one of the most advanced is the Chinese proposal, a recombinant adenovirus vector-based vaccine with the SARS-CoV-2 S gene, which has already been tested in monkeys and is known to produce immunity. A phase I clinical trial will be started with 108 healthy volunteers, between 18 and 60 years old, in which three different doses will be tested.

Other proposals are being promoted by CEPI (Coalition for Epidemic Preparedness Innovations), an international association in which public, private, civil and philanthropic organizations collaborate to develop vaccines against epidemics. It is currently funding eight SARS-CoV-2 vaccine projects that include recombinant, protein, and nucleic acid vaccines.

mRNA-1273 vaccine (Moderna, Seattle)

It is a vaccine made up of a small fragment of messenger RNA with the instructions to synthesize part of the protein S of the SARS-Co-V. The idea is that, once introduced into our cells, it is these cells that make this protein, which would act as an antigen and stimulate the production of antibodies. It is already in the clinical phase and it has begun to be tested in healthy volunteers.

Preclinical phases

Recombinant measles virus vaccine (Pasteur Institute, Themis Bioscience and University of Pittsburg)

It is a vaccine built on a live attenuated measles virus, which is used as a vehicle and contains a gene that encodes a protein of the SARS-CoV-2 virus. It is in the preclinical phase.

Recombinant Influenza Virus Vaccine (University of Hong Kong)

It is also a live vaccine that uses an attenuated influenza virus as a vector, which has had the virulence gene NS1 removed, and is therefore not virulent. A SARS-CoV-2 virus gene is added to this vector virus. This proposal has some advantages: it could be combined with any strain of seasonal influenza virus and thus serve as a flu vaccine, it can be quickly manufactured in the same production systems that already exist for influenza vaccines, and they could be used as intranasal vaccines via spray. It is in the preclinical phase.

Recombinant protein vaccine obtained by nanoparticle technology (Novavax)

This company already has vaccines against other respiratory infections such as adult flu (Nano-Flu) and respiratory syncytial virus (RSV-F) in clinical phase III and has manufactured vaccines against SARS and MERS. Its technology is based on producing recombinant proteins that are assembled into nanoparticles and administered with its own adjuvant, Matrix-M. This compound is a well-tolerated immunogen capable of stimulating a powerful and long-lasting nonspecific immune response. The advantage is that in this way the number of necessary doses would be reduced (thus avoiding revaccination). It is in the preclinical phase.

Recombinant vaccine using as a vector the Oxford chimpanzee adenovirus, ChAdOx1 (Jenner Institute, Oxford University)

This attenuated vector is capable of carrying another gene that encodes a viral antigen. Models for MERS, influenza, chikungunya and other pathogens such as malaria and tuberculosis have been tested in volunteers. This vaccine can be manufactured on a large scale in bird embryo cell lines. The recombinant adenovirus carries the glycoprotein S gene of the SARS-CoV-2. It is in the preclinical phase.

Recombinant Protein Vaccine (University of Queensland)

It consists of creating chimeric molecules capable of maintaining the original three-dimensional structure of the viral antigen. It uses the technique called molecular clamp, which allows vaccines to be produced using the virus genome in record time. It is in the preclinical phase.

Messenger RNA Vaccine (CureVac)

This is a proposal similar to that developed by the modern biotechnology company, with recombinant messenger RNA molecules that are easily recognized by the cellular machinery and produce large amounts of antigen. They are packaged in lipid nanoparticles or other vectors. In preclinical phase.

DNA INO-4800 vaccine (Inovio Pharmaceuticals)

It is a platform that manufactures synthetic vaccines with DNA of the S gene from the surface of the virus. They had already developed a prototype against MERS (the INO-4700 vaccine) that is in phase II. They recently published the phase I results with this INO-4700 vaccine and found that it was well-tolerated and produced a good immune response (high antibody levels and a good T-cell response, maintained for at least 60 weeks after vaccination). In preclinical phase.

Cuba

According to the director of biomedical research of the CIGB, Gerardo Guilln, the Center for Genetic Engineering and Biotechnology (CIGB) of Cuba has a vaccine design that could be used against the new coronavirus.

According to the Cuban scientist, this vaccine is in the methodological and design phase. However, according to his statements, there is an advanced path since a platform that the institution has already developed is being used, where it works with virus-like particles with great capacity to stimulate the immune system.

Another platform that is very attractive and promising being developed by the center is by immunization through the nose. Cuba has experience in this regard, since it has a registered vaccine that uses this nasal spray.

The Cuban vaccine candidate is being developed with the Cuba-China joint research and development center, located in Hunan province. It is not known when clinical trials could begin.

Cuba is also carrying out research in therapeutic drugs. The results so far published by China in the treatment of COVID 19, with the Cuban Interferon Alfa 2B, showed positive results.

***

All proposals for specific treatments and vaccines for COVID-19 are in the experimental phase. But technological advances and the accumulation of research results in the fields of antiviral therapies and vaccines against other viruses, and specifically against other coronaviruses, make many experts affirm that there is a high probability of success. Although we want and need faster responses, science cannot be asked to have a vaccine in less than a year, in reality that would already be a record time.

The international scientific communitys actions, in terms of sharing scientific results, collaboration and training, is the backbone of this battle, and my greatest hope.

Read more:
Why can't we have a COVID-19 vaccine right now? - OnCubaNews

Posted in Genetic Engineering | Comments Off on Why can’t we have a COVID-19 vaccine right now? – OnCubaNews

Column: Roswell Park’s alliance with Cuba gets the ‘wow’ treatment from PBS’ ‘Nova’ – Buffalo News

Posted: at 5:55 am

Wow.

Thats the word Candace Johnson, the president and chief executive officer of Roswell Park Comprehensive Cancer Center, uses early in Cubas Cancer Hope. It airs as part of the PBS series Nova at 9 p.m. Wednesday.

She added the words, in Cuba, jeez, referring to the small communist countrys work on a vaccine for the treatment for certain forms of cancer.

But the word can also be applied to the positive national publicity Roswell Park is receiving in the program.

"Wow," indeed.

It certainly could use some good publicity after Roswell Park fired a top executive over the weekend for things she wrote on her Facebook page that bashed President Trump's response to the Covid-19 outbreak.

The Nova documentary plays like a promotion for Roswell Parks partnership with Cuba in search of a treatment. Roswell Park is especially highlighted in the second half of the hourlong program.

Several Roswell Park doctors, including Dr. Kelvin Lee, Dr. Kunle Odunsi, Dr. Mary Reid, Dr. Grace K. Dy and Dr. Joseph Tario, appear. The program centers around how Roswell became involved with scientists in a small Communist country where American citizens go to receive treatment illegally because of a United States trade embargo that complicates the relationship between the countries.

Dr. Kelvin Lee (Photo courtesy of Roswell Park)

I think everyone here thought that Cuba was stuck in I Love Lucy days, the 1950s, old cars, there cant possibly be good science going on, Lee says early in the program.

The beautifully filmed hour also may appeal to supporters of Democratic presidential candidate Bernie Sanders, who was criticized for old comments about Fidel Castros regime in Cuba expanding education and health care.

Cubas Cancer Hope acknowledges Castro's dictatorial sins that led to half its doctors leaving the country early in his reign. But it also credits the dictator for emphasizing science and giving Cubans something not available to all Americans free health care.

Lee and other doctors give a basic understanding of immunotherapy, genetic engineering, checkpoints and what Cuban scientists have discovered in the treatment of cancer that has resulted in some Americans going there to extend their lives.

"Cubas Cancer Hope humanizes the story by following some people who have been given the treatment and lived beyond expectations.

The question of how Roswell Park was chosen as a partner is raised, but not as thoroughly as I hoped. Odunsi explained that he was told Roswell Park was approached because it was one of the few institutions where discoveries in Cuba could be taken to the next level.

The relationship began in 2011 when Cuban doctors made a presentation at Roswell Park before a standing room audience.

Scientists, were a little crazy, Johnson explained. We all want to hear something really interesting. It sparked curiosity of how it came to be ... Wow, in Cuba. Jeez.

The bigger question is whether all the challenges of bringing the potential life-extending drug to Buffalo and across the United States will ever be conquered.

If it does, wow will be an understatement.

Dr. Candace Johnson (Photo courtesy of Roswell Park)

In a telephone interview, Johnson made aspects of the development of the partnership between Roswell Park and the Cuba doctors sound even more dramatic than portrayed in the documentary.

She noted that the April 2015 trade mission led by Gov. Andrew Cuomo that resulted in Roswell Park signing an agreement with Cubas Center for Molecular Immunology to set up a clinical trial for a lung cancer vaccine CimaVax was done under unusual circumstances.

At the time that (Cuomo) did that, that was pretty bold because no one had really gone there, she said. I was asked to go with Kelvin Lee and they had to charter a plane that left from JFK (Airport in New York City). The CEO of JetBlue was on the plane. They had to carry their own mechanics because there were no mechanics in Havana, there was no way to pay them. There was no way to pay rent. They refueled and left and refueled at Fort Lauderdale.

It was precedent-setting to say the least, she added. And then for us to come out of that trip with an agreement with the CIM to be able to work with, test and work toward doing a clinical trial was really exciting. When we first came back from Cuba from that trade mission, the world was abuzz because at that time really no one was going to Cuba.

I think for the whole world it was, 'what's going on here? I mean we did interviews from that very first trip from places all around the world. I guess the thing that I'm most proud of is that it wasn't just a flash in the pan where we got in the spotlight at the Havana airport with the governor. But we actually did something and we worked hard to be able to use this vaccine approach in a clinical trial that is ongoing.

Johnson hasnt seen the documentary, but she views it as a really intriguing story that gave Cuban doctors the respect they have sought and deserved.

When we first started talking about Cuba and this has changed the Cuban scientists and this vaccine, the arrogance that you would hear from people, she recalled. Why are they smarter than we are? They are just a third world country. How could they possibly be doing anything that's maybe better than we have? So I think it's a combination of sort of a little guy doing well that also makes this story pretty interesting.

She had a more thorough answer to why the Cuban scientists chose to partner with Roswell instead of cancer centers that are bigger, more famous or have more money.

I think the one thing that really contributed to that is Dr. Lee is a very engaging guy, she said. Youve got to look Cubans in the eye. They have to know you to trust you. And I think part of the reason we were successful is we developed a trust between our two institutions even though the politics between our two countries is very tense and sometimes controversial."

If the vaccine eventually passes the clinical trials, Johnson expects the Food and Drug Administration would approve its use in the U.S. so patients would no longer need to go to Cuba.

I know everything that we do with Cuba can be a challenge because of the relationship between our two countries, Johnson said. Were very hopeful. It seems to me it would be very difficult from the FDA's perspective, if this drug has a role, that it wouldn't be available in this country.

email: apergament@buffnews.com

Read the original post:
Column: Roswell Park's alliance with Cuba gets the 'wow' treatment from PBS' 'Nova' - Buffalo News

Posted in Genetic Engineering | Comments Off on Column: Roswell Park’s alliance with Cuba gets the ‘wow’ treatment from PBS’ ‘Nova’ – Buffalo News