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Monthly Archives: March 2020
The Catholic Church proposes AI regulations that protect people – The Verge
Posted: March 5, 2020 at 6:24 pm
Vatican officials are calling for stricter ethical standards on the development of artificial intelligence, with tech giants IBM and Microsoft being the first companies to sign its new initiative.
The Rome Call for AI Ethics lays out six broad principles: transparency, inclusion, responsibility, impartiality, reliability, and security and privacy. These principles say that technology should protect people, particularly the weak and underprivileged. They also urge policymakers across the world to create new forms of regulation on advanced technologies that have a higher risk of impacting human rights, which includes facial recognition.
AI is incredibly promising technology that can help us make the world smarter, healthier, and more prosperous, IBM vice president John Kelly III said after the initiatives signing. But only if it is shaped at the outset by human interests and values.
The Vatican wants to ensure that companies are not using AI as a means to collect data without the consent of individuals and then using that data for commercial or political benefit. In one recent example, it was shown that thousands of federal government agencies and private companies were using software owned by face recognition company Clearview AI, which scraped facial data without peoples knowledge. The companys database, which features more than 3 billion images pulled from various online sites, is being used by law enforcement to catch persons of interest.
The document also says that a duty of explanation must be established and that AI-based algorithms should provide individuals with information on how these algorithms came to their decisions to ensure that there is no bias. Last year, US lawmakers introduced a bill that would do just that and allow the Federal Trade Commission to create rules that would force these companies to evaluate automated systems containing highly sensitive information.
Vatican officials hope to increase the number of signatories for its AI ethics initiative in the coming months. They also hope to collaborate with universities across the globe to promote more scientific research into ethical AI guidelines.
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QRI and Emerson partner on AI-based oil and gas E&P analytics – Hydrocarbons Technology
Posted: at 6:24 pm
]]> Collaborating with QRI enables Emerson to enhance its capabilities in giving useful analytics to maximise production. Credit: Paul Lowry.
US-based companies Emerson and Quantum Reservoir Impact (QRI) have collaborated to develop applications for artificial intelligence (AI)-based analytics for oil and gas exploration and production (E&P).
The two companies will also develop and market decision-making tools for E&P analytics.
The collaboration aims to help oil and gas customers to harness data to optimise their reservoir management strategies.
It will also enable customers to enhance digital transformation technologies.
Emerson E&P software president Steve Santy said: Collaborating with QRI enhances our capabilities to give customers meaningful analytics to maximise production and capital efficiency and for better reserve assessment.
The partnership integrates Emersons E&P software portfolio with QRIs expertise in applying augmented AI, machine learning (ML) and advanced analytics for reservoir management.
Emerson and QRI will also apply advanced computational technologies to help geoscientists and engineers make actionable field development decisions to achieve higher productivity.
QRI chairman, CEO and co-founder Nansen Saleri said: People, process and data are as important as technology to the success of the solution. Our partnership with Emerson makes for a very powerful team to ensure that our offerings will become a prominent choice in the market.
As our industry continues to transform, we share Emersons vision of applying state-of-the-art deep learning tools to automate next-generation workflows and offer our customers a rapid means of generating value.
In July, Emerson acquired Zedis software and automation businesses to help accelerate digital transformation in the oil and gas industry.
In March 2019, Emerson formed a strategic alliance with Repsol to provide advanced subsurface geophysical technologies to expedite production.
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B.C.’s Athena industry initiative aims to train 500 women in AI – Business in Vancouver
Posted: at 6:24 pm
Athena Pathways Consortium will be training 500 B.C. women in AI, machine learning and data science for at least 18 months | Credit: Shutterstock
What happened: Industry group launching new program to expand artificial intelligence expertise for hundreds of B.C. women
Why it matters: Initiative will try to improve gender balance in male-dominated tech sector
B.C.s artificial intelligence community wants to get smarter about correcting its considerable gender imbalance.
The Athena Pathways Consortium officially launched Thursday (March 5) with the goal of training 500 B.C. women in AI, machine learning and data science over the next 18 months.
Its the almost hidden costs of not doing this that are particularly pernicious, said AInBC executive director Steve Lowry, whose industry association is spearheading the initiative backed by a mix of private sector and post-secondary players.
When you look at organizations that arent gender-balanced or diverse enough, they underperform.
Athena Pathways sees the University of B.C., Simon Fraser University, the B.C. Institute of Technology and Northeastern Universitys new Vancouver campus developing courses and workshops for women at high school and post-secondary levels as well as those already in the workforce.
While the initial phase of the program, budgeted at $682,000, will offer 300 scholarships and is set to run 18 months, Lowry said Athena Pathways could extend beyond that as it hunts for additional donors.
In addition to AInBC and the aforementioned post-secondary institutions, Athena Pathways is receiving support from Vancouver-based Canadas Digital Technology Supercluster, D-Wave Systems Inc., Metaoptima Technology Inc. and Tech Resources Inc. (TSX:TECK.B), among others.
B.C.s technology sector is among the most male-dominated in Canada.
Women account for 18.3% of Vancouvers tech workforce, according to a 2019 report from real estate services firm CBRE Group Inc.
Thats the second-largest gender disparity among Canadian cities, tied with Saskatoon.
The only Canadian city to fare worse in the rankings is Victoria, where women compose 15% of the technology workforce.
The B.C. Tech Association unveiled 15 recommendations for the tech sector in December 2019in a bid to create an ecosystem much better at recruiting and retaining women.
Among the recommendations curated from a series of workshops, panels and roundtables:
Set targets and publish the results. Ask if your employee diversity mirrors that of your customers.
Leverage your teams network: ask women in your organizations to identify people theyve worked with in the past and would like to work with again.
Ask yourself if talent is promotable before someone takes parental leave consider promoting before they take leave.
Put in place salary bands for each role, track and communicate pay vs. industry averages (compa ratios). Establish and enforce minimum salaries for each role.
Our objective is to make this easy for people by giving concrete, actionable suggestions, B.C. Tech Association CEO Jill Tipping told Business in Vancouver in December.
Were not trying to be one size fits all. Were trying to give you a menu of options and challenge you to find at least one that would work for your business.
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T’s Kamran Khan on how his startup used AI to spot the coronavirus before anyone else: CNBC – News@UofT
Posted: at 6:24 pm
Nine days before the World Health Organization alerted the world to the threat posed by COVID-19, an artificial intelligence-powered startup led by the University of Torontos Kamran Khan had already spotted the first signs of an unusual outbreak.
In an interview with CNBC, Khan explained how his company, BlueDot, was able to scour big data and spot the emergence of the novel coronavirus before anyone else.
He said BlueDotuses machine learning and natural language processing to comb through masses of data, which are then reviewed by doctors and computer programmers who create threat reports.
We dont use artificial intelligence to replace human intelligence, we basically use it to find the needles in the haystack and present them to our team, said Khan, an associate professor at the Institute of Health Policy, Management and Evaluation at the Dalla Lana School of Public Health and an infectious disease physician at St. Michaels Hospital.
He said his experience treating patients during the SARS outbreak in 2003 inspired him to start BlueDot.
What I learned during SARS is, lets not get caught flatfooted, lets anticipate rather than react.
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Surgery and AI give amputees better control of prosthetic hand – STAT
Posted: at 6:24 pm
People with limb injuries severe enough to require an amputation have few options to regain meaningful function in their arms or legs. Commercial prostheses, even modern ones, dont come close to what nature created, enabling movement that feels disjointed and artificial.
In a new study published Wednesday in Science Translational Medicine, a team of University of Michigan surgeons and computational scientists report a new procedure that captures electrical signals from nerves in the arm severed during an amputation and uses them to guide fine movements of a prosthetic hand. The work is one of a number of efforts underway to better integrate human physiology with robotics to improve the functioning of artificial limbs.
In the new technique, a flap of muscle is wrapped around the severed nerves to allow the nerves to grow and fire electrical signals. The signals are then picked up by an implant placed in patients the implant serves as a connection between the nervous system and a computer that patients are later hooked up to. Finally, a machine learning program interprets those nerve signals to allow patients to move a prosthetic hand seamlessly.
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The procedure described in the paper was initially tried on four patients, and the researchers report that the implant worked well in these volunteers for up to 300 days, which is how long the patients were observed. The patients were able to pick up small toy blocks and food cans and make a fist or pinch fingers together. The technology will need to be miniaturized and made wireless.
This is not the first such attempt to improve the state of prosthetics. Researchers at Brigham and Womens Hospital and MIT, for instance, have developed a new amputation method thus far tested in people requiring below- and above-knee injuries to help preserve patients sense of proprioception; the team has reported that patients who have undergone the experimental surgery feel as though the advanced prosthetics they wear are a natural extension of their body.
STAT spoke with Cynthia Chestek, a biomedical engineer at the University of Michigan and an author of the new study, to learn more. This interview has been lightly edited and condensed.
Why is it difficult to integrate prosthetic control interfaces with nerves?During amputation, a nerve is cut and while that nerve continues to carry signals about intended movements, its really hard to get those signals out. People for many, many years have tried to get prosthetic control down from a nerve, but the physics is just terrible. Its very hard to record these very small [nerve] signals, and its hard to put anything inside the nerve because it causes a lot of scarring. The state of the art right now is to record from whatever muscles are left at the skin, and that both gives you a very small signal and usually its not the signal that you want. So, for example, youre often using an elbow signal to make a hand open and close or operating a foot switch to make a hand open and close.
What is the advancement here?Our surgeon developed a technique where he takes a very small piece of muscle and he wraps it around the end of the amputated nerve. And then the nerve goes into that piece of muscle, and then what would have been an extremely small signal becomes a large electrical signal.
What happens next?So, then my team takes these electrical signals and we apply a variety of machine learning algorithms to them. And this enables our study participants to then control a prosthetic hand in real time. And these are the largest ever nerve signals ever recorded from a human being, and were showing what that enables us to do with a prosthetic hand. If youre trying to get a signal from a nerve, youre actually closer to 10 to 20 microvolts, whereas we get hundreds of microvolts and sometimes more.
Why does just wrapping a piece of muscle lead to this expanded nerve signal?The nerve is looking for a target to regrow into. And the nerve keeps growing until it finds something. Another major benefit of the surgery is as the nerve is growing into the muscle, it prevents a lot of pain [in a condition known as neuroma]. But now the nerve is happy, its found its muscle and the reason the signals get larger is because as muscles fire, they create this big electric field around them. So one nerve might be controlling a whole piece of muscle and thats going to create a much bigger signal.
What do you ask the volunteers in the study to do, and how do they feel about the prosthetic?We just ask the person to move as they normally would. We calibrate the machine learning [to these movements]. But we learn from that information and then use those signals to control the hand. So if the volunteers want to move the thumb across the hand, they just have to imagine it because the learning is in our algorithm, and not in the person. And importantly, after this surgery, they have so far all felt like they can move their fingers when theyre flexing that small muscle graft.
Does it take long for people to get used to it?It works on the first try. We were able to just ask people to make a bunch of movements that were showing them on the screen and then theyre able to replicate that with the hand. Weve increased the difficulty [of the movements] over the last couple of years.
Whats new about the algorithm?Were using a lot of the same sort of algorithms that are under the hood of autonomous vehicles. But whats new that patients are able to do is theyre able to control the position of their fingers better. Theres no commercially available system in which [they] can precisely control the location of the end of [their] thumb. So I think probably the coolest thing that we were able to show is our few participants positioning the point of their thumbs in two dimensions, and thats really useful if youre trying to pick up things. If you cant orient your thumb around an object, its very hard to grasp anything. And Im not aware of any other way of doing that because it really requires nerve signals since so much of your thumb muscles are in the hand.
Whats next?The cool thing about this surgery is it works on any type of amputation. Thats the good news. To take this [technology] home, this is still a report of the pilot study this still needs to be replicated to work in more people moving forward.
We are trying to figure out how to get people off the computer cart. Everything that weve done so far has been six feet away from a computer cart [and people come in once or twice a week for the trial]. We want people to be able to do this with an implantable device so we can move away from the cart. We hope that, however many years it takes, this is something that one day enables people to control the fingers of the prosthetic hand at home and in their daily lives.
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Global Healthcare Artificial Intelligence Market was Estimated to Grow at 25.9% CAGR During the Forecast Period Due to the Rising Adoption of…
Posted: at 6:24 pm
Healthcare artificial intelligence market is estimated to be US$ 3,120 Mn in 2018 and is anticipated to grow at a CAGR of 25.9% over the forecast period owing to digitalization of medical device and patient registries
PUNE, India, March 5, 2020 /PRNewswire/ --In terms of revenue, the global healthcare artificial intelligence market is estimated to be US$ 3,120 Mn in 2018 and is anticipated to reach US$ 24,700 Mn by 2027 growing at a CAGR of 25.9% over the forecast period.
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The increasing use of electronic patient registry and medical device registries is leading to generation of potential datasets for application of AI technologies and deriving predictive insights. Electronic patient registry or electronic health record (EHR) are used by hospitals and clinics to collect observational medical data of their patients. This data is collected and analyzed by a web-based software and can be made available to the medical community, government agencies and research organizations as per their requirement. It allows professionals in healthcare and other industries to analyze available treatments and how patients with various characteristics and medical history respond to these treatments. In a similar way, medical device registry is used to collect, store and retrieve data to medical devices and equipment used for healthcare delivery. The trend of electronically storing patient and device data in healthcare sector has been witnessing growth in past few years due to the digital revolution.
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Major players such as McKesson Corporation, IBM and others have introduced their EHR products. The rising adoption of electronic patient and medical device registry has led to generation of huge datasets which can be optimally utilized for analytical predictive purposes. AI and advanced analytics enable healthcare providers to extract patient-specific information from connected medical devices instead of having to analyze large, time-consuming and complicated datasets, thus propelling the growth of global healthcare artificial intelligence market. Such specific patient information can aid them to offer personalized medicines and diagnostics. For instance, Qualetics Data Machines Inc. offers an intelligence platform for healthcare industry which provides incisive insights using artificial intelligence, machine learning, natural language processing and predictive analysis coupled with data obtained from patient registries.
In other such instance, Saykara, Inc. has developed an AI based virtual assistant for physicians utilizing speech recognition technology, which listens in the background during attending any patient and automatically generates notes which is later updated in the EHR system. These application of AI technologies in combination with EHR systems are enhancing healthcare delivery and user experience thus enhancing the growth of global healthcare artificial intelligence market. Going forward deployment of patient and medical device registries on cloud platform further deepens the market penetration of these electronic registries thus creating extensive potential application for AI technologies. For instance, SyTrue in partnership with Microsoft has introduced Azure, cloud platform of Microsoft, based solution to manage health records through natural language processing technology. Thus, growing digitalization of patient and medical device registries are expected to boost the growth of global healthcare artificial intelligence market globally.
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The detailed research study provides qualitative and quantitative analysis of healthcare artificial intelligence market. The market has been analyzed from demand as well as supply side. The demand side analysis covers market revenue across regions and further across all the major countries. The supply side analysis covers the major market players and their regional and global presence and strategies. The geographical analysis done emphasizes on each of the major countries across North America, Europe, Asia Pacific, Middle East & Africa and Latin America.
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Alphabets DeepMind hopes to aid researchers with AI insight into COVID-19 virus structure – 9to5Google
Posted: at 6:23 pm
DeepMind is best known for AI that easily defeated the worlds best Go and StarCraft II players in recent years. The Alphabet-owned research lab is now applying its existing work to help researchers combating COVID-19.
To test for a virus and develop a vaccine, scientists must first understand how it functions, specifically the structure of viral proteins. Its a lengthy process that takes months and might not always yield results. Researchers in recent years have turned to computer predictions, with DeepMinds deep learning system known as AlphaFold.
Work on the coronavirus is under way at labs around the world. DeepMind hopes to aid that research by releasing structure predictions of several understudied proteins associated with SARS-CoV-2, the virus that causes COVID-19.
We emphasize that these structure predictions have not been experimentally verified, but hope they may contribute to the scientific communitys interrogation of how the virus functions, and serve as a hypothesis generation platform for future experimental work in developing therapeutics.
The team is quick to note that the data shared today is not the main focus of current therapeutic efforts, but might help general understanding. There are several other caveats, with DeepMind providing confidence scores and only tackling proteins that are a challenge for conventional modeling approaches.
Its important to note that our structure prediction system is still in development and we cant be certain of the accuracy of the structures we are providing, although we are confident that the system is more accurate than our earlierCASP13 system. We confirmed that our system provided an accurate prediction for theexperimentally determinedSARS-CoV-2 spike protein structure shared in theProtein Data Bank, and this gave us confidence that our model predictions on other proteins may be useful.
According to DeepMind, it was encouraged to share its COVID-19 research with the general scientific community after consulting with structural biologists and virologists in the UK.
Normally wed wait to publish this work until it had been peer-reviewed for an academic journal. However, given the potential seriousness and time sensitivity of the situation, were releasing the predicted structures as we have them now, under anopen licenseso that anyone can make use of them.
Interested researchers can download the structureshere, and can read more technical details about these predictions in a document included with the data.
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New ‘Feed Your Mind’ Initiative Launches to Increase Consumer Understanding of Genetically Engineered Foods – FDA.gov
Posted: at 6:22 pm
For Immediate Release: March 04, 2020
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The U.S. Food and Drug Administration, in collaboration with the U.S. Environmental Protection Agency and the U.S. Department of Agriculture, today launched a new initiative to help consumers better understand foods created through genetic engineering, commonly called GMOs or genetically modified organisms.
The initiative, Feed Your Mind, aims to answer the most common questions that consumers have about GMOs, including what GMOs are, how and why they are made, how they are regulated and to address health and safety questions that consumers may have about these products.
While foods from genetically engineered plants have been available to consumers since the early 1990s and are a common part of todays food supply, there are a lot of misconceptions about them, said FDA Commissioner Stephen M. Hahn, M.D. This initiative is intended to help people better understand what these products are and how they are made. Genetic engineering has created new plants that are resistant to insects and diseases, led to products with improved nutritional profiles, as well as certain produce that dont brown or bruise as easily.
Farmers and ranchers are committed to producing foods in ways that meet or exceed consumer expectations for freshness, nutritional content, safety, sustainability and more. I look forward to partnering with FDA and EPA to ensure that consumers understand the value of tools like genetic engineering in meeting those expectations, said Greg Ibach, Under Secretary for Marketing and Regulatory Programs at USDA.
As EPA celebrates its 50th anniversary, we are proud to partner with FDA and USDA to push agricultural innovation forward so that Americans can continue to enjoy a protected environment and a safe, abundant and affordable food supply, said EPA Office of Chemical Safety and Pollution Prevention Assistant Administrator Alexandra Dapolito Dunn.
The Feed Your Mind initiative is launching in phases. The materials released today include a new website, as well as a selection of fact sheets, infographics and videos. Additional materialsincluding a supplementary science curriculum for high schools, resources for health professionals and additional consumer materialswill be released later in 2020 and 2021.
To guide development of the Feed Your Mind initiative, the three government agencies formed a steering committee and several working groups consisting of agency leaders and subject matter experts; sought input from stakeholders through two public meetings; opened a docket to receive public comments; examined the latest science and research related to consumer understanding of genetically engineered foods; and conducted extensive formative research. Funding for Feed Your Mind was provided by Congress in the Consolidated Appropriations Act of 2017 as the Agricultural Biotechnology Education and Outreach Initiative.
The FDA, an agency within the U.S. Department of Health and Human Services, protects the public health by assuring the safety, effectiveness, and security of human and veterinary drugs, vaccines and other biological products for human use, and medical devices. The agency also is responsible for the safety and security of our nations food supply, cosmetics, dietary supplements, products that give off electronic radiation, and for regulating tobacco products.
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03/04/2020
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Building ‘better’ astronauts through genetic engineering could be key to colonizing other planets – Genetic Literacy Project
Posted: at 6:22 pm
Space exploration has long been a source of fascination. Since the stars first captured our attention, we have obsessed over that vast curtain of darkness that lies beyond our atmosphere. But to what end? What ultimate goal does mankind strive towards, if not the ability to visit and colonize other worlds?
Before we can take our first steps out into the universe, we have to answer a critical question: Do we have the ability to adapt to other environments very different from what we have on Earth to not only survive, but to thrive? Instead of focusing on how we might terraform other planets to suit us, perhaps we should consider how we might use genetic engineering to alter own bodies to suit those other planets.
As a jumping off point, lets consider the feasibility of using the popular gene-editing tool CRISPR to alter human physiology to tolerate parameters outside of Earths norms. If we take a look at common factors that are significant to human health, gleaned from our experience with space exploration, the most obvious choices for our attention are variations in gravity, atmospheric pressure and gas ratios, and solar radiation levels.
If we consider Mars as our template, because of its relative suitability for colonization, then we must compensate for two-thirds less gravity than Earth. A lack of gravity results in a number of ill effects on human health, including a decrease in bone mass and density over time, particularly in the large bones of the lower extremities, as well as the spine. While we do not have research showing the impact of living on a planet with one-third Earths gravity, we do know that we can expect losses in bone density somewhere under 1-2 percent per month, the amount lost in the microgravity environment of space.
For comparison, the elderly lose 1-1.5 percent per month in Earth gravity. Atmospheric pressure that is either too high or too low also results in complications; low atmospheric pressure results in less oxygen available and causes altitude sickness and possible death. Radiation levels from the sun are another variable that is well known to have upper and lower thresholds for optimal human health, where low levels can lead to vitamin D deficiency and high levels increase cell death and cancer.
It would stand to reason that the human body has a minimum threshold for healthy physiology as regards the environment in which it grows, develops and lives. To colonize other planets successfully, we must consider solutions to overcome these thresholds; for example: prostheses, domed colonies recreating an ideal or near ideal environment, or, as this author suggests, the permanent genetic alteration of humanity as a species. This applies to our four chosen variables of gravitational forces, atmospheric pressure, atmospheric gas ratios, and solar radiation levels. While science fiction might have us consider surgical and biomedical prostheses or the more far-fetched use of animal DNA to change ourselves for this purpose, the key to human adaptation for other planets lies in our own genetics and it may well be CRISPR, the use of the enzyme Cas9 for introduction of altered DNA sequences or CRISPRs to existing cells to change how those cells function, that will make this possible.
Human genetic variation provides a veritable treasure trove of adaptations if one looks at the less common but heritable variations that on Earth may seem irrelevant, nonessential, or even maladaptive, but on another planet could be essential to survival. One example of a gene that, with engineering, could help humanity adapt to higher or lower gravity is the LRP5 gene. Recent research into the LRP5 gene shows that mutations of the gene are responsible for both low bone density and elevated bone density in the case of the later, from increased bone formation. A family of individuals in Nebraska carrying the mutation for elevated bone density have never experienced broken bones even well into old age. A whole colony of such individuals or ones engineered to enhance this mutation further could be expected to fare much better during prolonged space travel in zero gravity as well as in the low gravity environment on a planet like Mars.
While an atmospheric pressure and gas makeup very similar to Earths would be required for humans to survive and thrive outside of a spacesuit, Nepals Sherpas, high altitude dwellers in Ethiopia, and the Collas people in the Central Andes , as well as the deep sea divers of Bajau, may provide a solution to living on planets with differences in atmospheric pressure and oxygen availability. The three groups of high-altitude dwellers appear to have separate adaptations for thriving in low oxygen environments. Recent research indicates that there are genetic mutations in each of these groups. Sherpas mutations allow for more efficient use of available oxygen and resistance to ill effects from hypoxia.
Sherpas experience less of an increase in red blood cells than others and therefore avoid the ill-effects caused, such as edema and brain swelling. Sherpas instead have mitochondria in their cells that make more efficient use of the available oxygen, as well as having more efficient anaerobic metabolism in the absence of oxygen. The Collas show genetic differences in genes that control heart morphology, as well as cerebral vascular flow, as a means to withstand an elevated hematocrit in response to high altitude living. The Amhara people living in high altitudes in Ethiopia unlike the Sherpas do have lower oxygen saturation and higher hemoglobin levels compared to lowland dwellers in the region.
Research has yet to determine what adaptation favors the Amhara, but several genes that may play a role have been isolated. Another group, the Bajau of Thailand, may have complementary genetic variations that help them resist hypoxia and survive the high pressures of deep sea diving. Researchers found them to have 50% larger spleens and also a gene, PDE10A, that controls a thyroid hormone thought to affect spleen size. Capitalizing on any of these genetic features would improve our ability to survive with a lower oxygen content atmosphere, perhaps on a newly terraformed Mars or under domes with oxygen rationing.
While we cannot yet determine how comparable an atmosphere we can create on Mars, it stands to reason that achieving an exact replica atmosphere to Earths could be difficult. An atmosphere that lets in less radiation could impede our production of vitamin D, while a thinner atmosphere would admit an excess of radiation. Vitamin D deficiency could perhaps be handled by supplementation, or instead addressed by increasing our cells response to ultraviolet light to increase vitamin D synthesis. On the other side of the coin, a thinner atmosphere opens us up to higher UVR, which would result in higher rates of skin cancer.
It would stand to reason that, while skin pigmentation has high cultural and historical significance, it could make our species more suitable for colonization of high radiation planets; darker skin with larger melanocytes that react proactively to UVA and UVB radiation through tanning and higher antioxidant and free-radical counteraction would be protective and provide an advantage if we are to branch out into our solar system and beyond. At the same time, this solution poses the problem of vitamin D production.
The answer could lie in isolating and using the genes responsible for East Asian populations lower skin pigmentation coupled with lower skin cancer rates than European populations. A study headed by Pennsylvania university has isolated gene mutations responsible for skin pigmentation differences, SLC24A5, MFSD12, OCA2, and HERC2, by studying African, South Asian Indian, and Australo-Melanesian populations, some of which are associated with vitiligo and a form of albinism common in African populations. These mutations that confer higher vitamin D production to Europeans are not present in East Asians, indicating a different mutation responsible, and, while both populations have higher vitamin D production than African populations, Europeans have a 10-20 percent higher rate of cancer than both Africans and East Asians. Further research into these genes could provide targets for CRISPR to modify the protective factors in our skin without sacrificing vitamin D production of potential colonists.
The question remains: is CRISPR a feasible route to including some of these adaptations to create a new, more suitable colonist? To answer this question we look at the current status of CRISPR research.
While some experiments using CRISPR gene editing were conducted in the technologys infancy, including the controversial creation of twin girls in China designed to be resistant to HIV, we are still quite a bit of research away from using CRISPR with high success rates and full confidence, especially considering the repercussions of rushing into human trials, including the death of trial participants and long-term side-effects of cancer, both of which have occurred in gene-therapy trials.
According to information revealed by the FDA and NIH, 691 trial volunteers died in gene-editing trials prior to the tragic and high-profile death of Jesse Gelsinger in a 1999 trial to treat his OTCD, a rare metabolic disorder. The death was blamed on ethical oversights and a rush to make gene editing pan out before it was ready. The result was a long period of gene-editing fear and oversight but also, in the case of James Wilson, director of the University of Pennsylvanias Institute for Human Gene Therapy responsible for the trials that led to Gelsingers death, greater caution in research methodology. He has put safety at the forefront of his research and asserts that even still the risks of gene editing with CRISPR and other methods brings enough risk to justify human trials only for those diseases that are severe and debilitating enough for patients to accept the risks of gene editing.
What does all this mean for our hypothetical future of using CRISPR to edit the DNA of human colonists for space colonization? Is the technology too far off to serve our purpose or fraught with too much risk? Is it beyond our knowledge and skill to accomplish? The answer to each of these questions is undoubtedly, no.
Weve had too much success in treating complex genetic conditions, like the creation of an immune system for Ashanthi Desilva born with severe combined immunodeficiency (SCVID). Weve unlocked too many keys to making gene therapy safer and more effective to discount the possibility of future use for the advancement of our species into harsher environments. While subsequent uses of gene therapy for SCVID resulted in development of Leukemia years later, further advancements in the research have revealed the need to find the best delivery system for each body system. Adeno-associated viruses, and lentiviruses are being looked at in place of the more aggressive adenovirus or retroviruses for delivery of DNA segments both of which are less likely to provoke an immune response and less likely to trigger cell death by way of the B35 gene in healthy cells, and later cancer.
Regardless of the work ahead and the bumpy road that gene therapy has traveled, vast potential remains at our fingertips whether it is through use of CRISPR or future gene therapy tools. It is a sure eventuality that we will one day have these skills at the ready to spread our species into other worlds, well-equipped to survive and thrive in harsher environments.
Cherrie Newman is a writer and student of human reproduction and biological sciences. She is the author of a science fiction novel series entitled Progeny under the pseudonym CL Fors. Follow her on her blogor on Twitter @clfors
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Building 'better' astronauts through genetic engineering could be key to colonizing other planets - Genetic Literacy Project
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The Pacific Declaration: 20 Years Later – Earth Island Journal
Posted: at 6:22 pm
When my father, Marc Lapp, died in 2005 at the age of 62 from glioblastoma, he left behind a wife, five children, two stepchildren, and an unfinished manuscript. In the wake of his death, while struggling to make sense of a world without him, I holed up in a writers retreat on the rocky coastline of Provincetown, Massachusetts to see if I could transform his rough ideas into something presentable and publish what would have been his 15th book.
I never succeeded. But the central idea of his book has stayed with me all these years. Drafted at the dawn of the age of genetic engineering long before the development of CRISPR technologies and new ways to alter life as we know it the books message was simple: Weve developed frameworks within and across nation states for protecting environmental integrity for future generations (think the US Endangered Species Act). Now, as we attempt to alter the genetic makeup of living beings, we need new strategies and frameworks for protecting the planets genetic integrity for future generations. He was writing as a scientist, an ethicist and a parent.
I have been reflecting on his insight from so many years ago on the 20th anniversary of The Pacific Declaration, a statement of the ethical principles for this era of genetic engineering that my father and two dozen scientists, ethicists, and authors crafted on another rocky coastline in Bolinas, California and published in October 1999.
The Declaration states: In recognition of the fundamental importance of our planets natural genetic heritage and diversity, and in acknowledgment of the power of genetic engineering to transform this heritage, [we] believe that the proponents and practitioners of genetic technologies must adhere to the principles of prudence, transparency, and accountability.
The document was fundamentally a call to apply the precautionary principle to our collective approach to genetic engineering. The authors noted that the burden of proof must be on those promoting genetic engineering to show that these technologies contribute to the general welfare of consumers, farmers, and society. And that they do so, importantly, without compromising the viability of traditional agricultural practices, including organic farming.
The Declaration was also a call to bring democratic deliberation to decisions about regulation and research priorities: In democratic societies, any decision to deploy powerful new technologies must be made with full public participation and accountability, the Declaration states. And it was a demand for food sovereignty, the concept developed in the 1990s by the global peasant movement, La Via Campesina, that calls for farmer and community power over what food is grown, where, and how.
The month after my father and others gathered to write this Declaration, I found myself getting tear gassed in the streets of Seattle. At the time, I was a graduate student at Columbia University, studying trade policy and globalization. Participating in the global action against the World Trade Organization the so-called Battle of Seattle felt like an appropriate extracurricular activity.
The Seattle action was also intimately tied to the work of my father and his colleagues. For the massive demonstrations in November 1999 against the new global trade regime were also about the future of food and how genetic engineering would affect farmers and eaters all around the world. In the streets, I heard as much from the Teamsters and environmentalists as I heard from Mexican farmers calling for protections of their corn markets in the face of American genetically engineered corn imports.
Since the Pacific Declaration was penned in 1999, commodity agriculture in the US has been remade by genetic engineering. The majority of US corn and soy grown today has been genetically engineered most of it to be resistant to the toxic herbicide Roundup. And the impacts of genetic engineering can now be felt in communities around the world burdened with exposure to toxic pesticides used in concert with these crops, including the tens of thousands suffering from cancers thought to be linked to the weedkiller Roundup with lawsuits pending against its producer, Bayer (which bought Monsanto in 2018). Today, despite the urging of scientists like those who penned the Pacific Declaration, there are no precautionary principles in the US regulatory system for these technologies.
When my dad and his colleagues wrote the Pacific Declaration, it was a call for all of us to ask big questions of this new genetic age: Who benefits? Who is harmed? How do these decisions affect future generations? Twenty years later, these questions are just as pressing.
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The Pacific Declaration: 20 Years Later - Earth Island Journal
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