Monthly Archives: March 2020

The revolution will be televised: Meet the new Netflix stars who changed football forever – HeraldScotland

Posted: March 24, 2020 at 4:59 am

NETFLIX is notoriously secretive when it comes to publishing its viewing figures. Everyone's favourite streaming service did so for the first time ever in January last year, long before lockdown became part of the every day lexicon. However, in the absence of access to such information, a not-so bold prediction: the number of visitors to the platform will surge over the coming weeks as self-isolation becomes routine.

It's heartening to learn, then, that there are plenty of sports programmes at the fingertips, the latest of which entitled The English Game, aired for the first time on Friday. The story is told through the eyes of two men, Arthur Kinnaird and Fergus Suter, and focuses on the role each had in the transformation of football from gentleman's pastime to professionalism and the all-encompassing game that it is today idolised by millions globally and greatly missed as part of the Coronavirus shutdown.

Written by Downton Abbey creator Julian Fellowes, The English Game is, as one would expect, a lavish if slightly jarring period drama. The six-parter centres on a series of FA Cup ties between the dominant side of the late-1800s Old Etonians (Kinnaird's team) and Darwen, Blackburn Olympic and Blackburn Rovers (Suter's teams, of which the latter pair are contracted to Blackburn FC).

In the first episode, Kinnaird, played by Edward Holcroft, is painted as a conflicted individual, caught between admiration for a new style of play as deftly practised by Suter (Kevin Guthrie), a Scottish footballer of some renown, and a loyalty to his Eton contemporaries, who favour a rumbustious, brutal game not unlike rugby without handling.

At one point, after an FA Cup tie against Darwen ends in a draw with Kinnaird refusing the team of upstart millworkers the chance to play extra-time, he tells a gathering of dinner guests: We took a raggle-taggle pastime, with different rules wherever it was played and we turned it into a proper game . . . for gentlemen.

As is often the way with period dramas, dramatic licence triumphs over fact. Kinnaird is portrayed as antagonistic in that first episode. Yet history demonstrates that it was Francis Marindin, the Football Association president and Old Etonians captain, who denied Darwen extra-time and insisted on a replay, which was drawn before the holders won at the third time of asking.

In real life Kinnaird was not just one of the best English footballers of his day but a man of some substance. A keen sportsman, he still holds the record for most FA Cup final appearances and won honours in tennis, athletics, swimming and canoeing.

In his re-released book, Arthur Kinnaird: First Lord of Football, the author and football historian Andy Mitchell, relates that he did more to popularise soccer than any man who ever lived.

Mitchell, formerly the head of communications at the Scottish Football Association, says: He came on to the FA committee in 1868 when he was at university and stayed on the committee for the rest of his life. He was thoroughly involved in the complete transformation of the game from this public park pastime to crowds of 100,000. He died in the year Wembley Stadium was built, 1923, that was [an indication] of how much the game had been transformed in his lifetime, on his watch.

The son of a Scottish MP, he was a banker in the family business, an evangelical Christian who aided the disadvantaged during times of epidemic, helped to set up schools to educate poor children and was a champion of better treatment for women. His liberal outlook came from his father an advocate for the abolition of slavery in thre US and greater rights for Scotland - and informed his own opinions on what would become football's existential crisis.

He had an enormous social conscience and I don't know how he fitted it all in with a job as a banker playing football and going off to teach in ragged schools at night and doing all this work for charity but he seemed to have a huge amount of energy and fitted it all in, says Mitchell. He was a great guy and deserves more recognition not just for his football achievements but for everything else that he did in helping the poor and disadvantaged in late-Victorian society.

The way he was brought up was to be very inclusive and to see the worth in everyone. His mother was very busy in charity and you can see this coming through. He took on his parents' charities after their deaths, running the YMCA, the YWCA, he did a lot of charitable work for women and he made a lot of speeches calling for better treatment of women in the workplace, better wages and this is pre-First World War. So, in some respects, he was ahead of his time.

Mitchell, who worked as a consultant for The English Game on specific stuff like how goalposts were put up, says the series should be viewed as a social drama, rather than historical documentary.

I didn't have much influence over the script itself. Every pocket historian is going to say 'that's not right' as is the way with any period drama. If you were so inclined, of course you could pick holes in the history. Basically it is a social drama showing how this transformation took place over a period and how the passing game came to be introduced to England and although the main protagonist is Scottish and people say 'Oh, it should be called the Scottish game' in fact, it is all about football in England and how that was transformed by the efforts of the Scottish players.

One of the main changes that followed the appearance of the first Scot was the advent of professionalism. Suter had been lured to Darwen with the promise of a job after losing his own as a stonemason following the collapse of the City of Glasgow Bank. Jimmy Love his team-mate had been a local contractor in the city before he, too, found work had dried up.

If some of this sounds eerily indicative of the uncertainty facing all of us today, there is a crumb of comfort in the discovery that Kinnaird, the son of a Scot, and Suter, who became known as one of the Scotch Professors (the name given to the trailblazing Scots who changed the way football was played) ushered in a new era while embracing a style that retains many of those hallmarks today.

However, the main objections to the presence of Scots in the English game was not about the manner in which they played the game but a rather more insidious problem; the use of ringers or paid professionals by northern teams which prompted a switch in the balance of power away from the traditionally dominant London clubs.

The top players, like Fergus Suter and Hugh McIntyre at Blackburn were given very soft loans so that they could buy a pub, adds Mitchell. Quite a few of them end up in the licensed trade, a fair few of them went bankrupt through their own lack of skills and knowledge but they were set up in business. And, if you're running a pub, you can take time off, you can play football. It was a means of getting people down, making them available for the football team but also giving them a decent living. This went on and on.

In 1884, with more and more players appearing from Scotland, the Football Association, faced with a tide they could not turn back voted to embrace professionalism, something that Kinnaird was, given his liberal sentiments, thoroughly at ease with.

He had no regrets, says Mitchell. Some of his contemporaries thought it was appalling the way the game had been spoiled by professionals and it was a shoddy concern but Kinnaird was very positive. Charles Alcock [the FA secretary] and Kinnaird led the charge and worked together to make sure that professionalism was adopted.

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The revolution will be televised: Meet the new Netflix stars who changed football forever - HeraldScotland

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The story of ‘the other Clifton and Ashton’ and their remarkable links to Bristol – Bristol Post

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It is perhaps Bristols most famous area, with its zoo, bridge, brightly coloured houses and Georgian grandeur.

From the top of the hill next to the Clifton Suspension Bridge, the stunning view of the south west corner of Bristol takes in the river and the Cumberland Basin first, and just a mile or so away on the other side of the river is the south Bristol suburb of Ashton.

There are at least 20 other places in England called Clifton, but none more famous than the one at the top of the hill above Ashton.

And there are at least 50 other places around the world called Clifton - including 27 in the USA alone.

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You can find Cliftons in most of the English-speaking world - from Canada to New Zealand and Australia to South Africa. The Clifton area of Karachi in Pakistan is one of the poshest in the city - the bit on the coast where all the rich people live.

There are 14 places called Ashton in the United States - although the combined total population of them all is not greater than the number of people who live in Ashton in Bristol.

But there is another place where Clifton and Ashton are a mile and a half apart - and thats not in Bristol.

Its a place with huge, fascinating, disturbing and historic links to Bristol that still resonate to this day.

So, while were stuck indoors and need a bit of escapism, lets virtually go to the other Clifton and Ashton, and find an amazing place with long-standing links to Bristol, 4,210 miles away.

The tiny Union Island in the Caribbean is known as the Tahiti of the West Indies, because the shape of its volcanic mountain, rising out of the sea, is reminiscent of the famous South Pacific island.

Union Island is just three miles across and a mile up and down and, with the great big mountain in the middle, its population of around 3,000 live mainly in two little towns.

By the sea, the beach and the harbour is Clifton, the principal town of the island.

And a mile and half over the foothills to the west, around the coast a little way, is Ashton.

Do they play football in Ashton, and eat in expensive restaurants in Clifton?

Well, yes and no.

While Bristols Clifton has the Ivy and many other places of fine cuisine, there probably isnt anything quite as nice or relaxing as the Barracuda Restaurant, overlooking Clifton Harbour.

The harbour is a natural haven, with rocky outcrops encircling a sweeping curve of coast.

On a little peninsula to the east of Clifton is the little airport - with flights to bigger islands in the Caribbean being operated by a handful of the many airlines in the region.

Clifton and Ashton rely to a large part on being a beautiful stopover point for the tourists who sail about on the Caribbean on yachts.

That may be charter tours for a day, or island-hoppers who spend a few days or weeks there.

There are a few hotels, bars and restaurants, and watersports is a big thing on Union Island too.

Clifton Harbour is usually filled with kite surfers, while the other beaches around the island are popular with scuba divers.

The island is part of the St Vincent & the Grenadines nation, and its section of the island guide - written by the locals - describes a rocky island which is still largely untarnished by modern things like tarmacked roads and skyscraper hotels.

Take a ride on one of the half-dozen dollar buses for an overview of the island, it said.

Youll be surprised as to how little of the island is paved. Mountain bikers will appreciate this the most as the traffic is minimal and the terrain as varied as the road itself.

From Clifton, head up Fort Hill, the peak above the airport. The road looks impassable, but its not impossible. A few picnic tables are scattered across a shaded pasture, it added.

A cannon faces toward Carriacou and another strategically points to the entrance of the harbor. The view from the top is the best in all this island chain. On a clear day, both St. Vincent and Grenada are visible. After the breathtaking scenery, careful maneuvering down the rugged hillside feels adventurous.

Continuing over the hill, the hardtop road weaves through grazing lands with houses dotted here and there. We wouldnt recommend that any bushwhacking hikers attempt shortcuts through the scrub; the thorns in the bush are sharp as sea-urchin quills.

Past where the pavement ends by the seashore are mangroves, their propped-up root systems sticking out of the water. Large holes in the ground are home to crabs.

This is an ideal feeding area for crabs, shrimp and several species of fish that feed on leaf particles. Birders can expect to see kingfishers and herons here, with cattle egrets in the nearby fields.

South of Clifton, the road steeps over to Ashton, Union Islands second village. If you manage to get past the school cricket field without stopping to watch a game, continue on to Campbell, where the houses thin out. A reef system lies in Ashton Harbour between Union and Frigate Island. The road pushes toward the southern end of the island, no doubt with future residential development in mind, it added.

So while Ashton in Bristol is set to rapidly expand with housing developments happening, planned or mooted from the river bank to the Alderman Moore Allotment site, to Ashton Gates big Sporting Quarter expansion to the fields between Ashton Vale and the Long Ashton park and ride, the same is true for Ashton on Union Island - a new road stretching out south west along the coast is pointing to further development.

Clifton in Bristol is famous for its Whiteladies Road - a (usually) busy, bustling row of bars and pubs. The Clifton on Union Island is famous around the Caribbean for one bar in particular - Happy island.

About ten or 12 years ago, a Clifton resident called Janti Ramage started collecting all the empty conch shells that litter the shoreline.

He then decided that there were enough to stack up together, cemented with concrete, and create an artificial island, out on the rocky harbours edge.

He named it Happy Island, and its just about big enough for a bar, a kitchen and seating area.

Its patrons come by boat, of course, and are a mixture of local fishermen and workers in the tourism industry, and tourists themselves, with some enterprising local boat operators dropping off the rich Americans and telling them theyll pick them up in a couple of hours.

The reviews on TripAdvisor are overwhelmingly positive, describing Janti as the singing, smiling king of his little creation, with some tasty cuisine and his own mix of spiced rum punch, that people (on the whole) dont appear to mind paying ten dollars a glass for.

What almost everyone who goes to Happy Island remarks about is how the island is so small that you will be sitting there watching the kite surfers zip about on the water around you, and they will often take off and fly over the island - and the heads of the punters sitting at the tables.

Janti is described as a local legend - the nearby Palm Island donated some palm trees for his new kingdom, and his barbecued lobster is renowned across the area.

Perhaps the biggest party in Clifton is a relatively recent addition to the calendar - the Downs Festival, which takes place on the first weekend of September.

Ashton, meanwhile, is home to Bristols biggest cultural event - the annual Bristol Balloon Fiesta, which takes place at Ashton Court.

In the Clifton and Ashton 4,000 miles away, there are also two big events of the year - Easterval is a big thing during Holy Week in the run up to Easter, and then, in late May, theres a day long celebration which begins before dawn and lasts well into the night called the Maroon.

It involves a huge party, a carnival with drums, dancing and lots of food and marks the passing from the dry season in the first half of the year, into the rainy season - if the party doesnt happen, maybe the much-needed rains wont come.

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Like all of the islands in the Caribbean, the original settlers, the Arawak and the Caribs, were soon killed or died of disease when colonisers from western Europe arrived in the 16th century.

The island was one of many hundred in the Caribbean taken over by French and English slave traders and plantation owners, and the slopes of the big hills on Union Island were fertile for growing cotton.

Things started getting serious for Union Island in 1763 when the French handed over St Vincent & the Grenadines to the English, and the English immediately rewarded one of its own navy chiefs, Admiral Samuel Spann.

Spann gave Union Island its name, and immediately started filling the cotton plantations with enslaved people from the regions of Africa that are now Nigeria, Cameroon, Angola, and Ghana.

Spann was an influential man in Bristol, as well as on Union Island - where he literally owned not just the island but the people who lived there too.

The people brought to Union Island in chains on board Spanns Bristol-crewed boats were forced to work on the cotton plantations, and the villages they built were named Clifton and Ashton by Spann himself.

The names were given in honour of the two places on either side of the River Avon that the boats passed through on their way out of Bristol Harbour, before they sailed to West Africa.

Theres a false urban myth that the people trafficked as slaves by Bristols merchants came to Bristol in large numbers - but its not true, only a handful would ever have seen the original Clifton and Ashton, only the prison villages named by Spann that the slaves had to build themselves.

Back in Bristol, Spann became the head of the Merchant Venturers, and it was to him that Bristols MP Edmund Burke - whose statue stands in The Centre to this day - wrote one of Burkes most famous letters.

About ten years after Spann first took control of Union Island, there was a big issue in the union of two islands back home.

Ireland was part of the British Empire, just like Union Island, but there was a fierce debate about whether taxes on goods coming from Ireland should be imposed or maintained.

Bristols MP Edmund Burke, who today is most famous for the quote about the only thing that needs to happen for evil men to succeed is for good men to do nothing, was an Irishman himself, and a passionate advocate for free trade and the end to taxes on trade with Ireland.

But Bristols Merchants, led by Spann, fiercely opposed the dropping of the duties - it put them at a huge advantage and they were making a lot of money out of it.

Burke wrote two lengthy letters to the Merchants - addressed to Spann - explaining his position. It wasnt popular with Bristols voters - who were only the rich men of the city - and he didnt last long as the citys MP.

Back in Spanns Clifton and Ashton, generations of African people lived and worked in slavery and poverty. The abolition of slavery by the British Empire in the 1830s brought huge fortunes to one Clifton and Ashton, and little change to another.

In Clifton in Bristol, the owners of plantations and slaves were given compensation which amounts to the biggest single pay out by the British Government in history - until this week.

In the 1830s, it amounted to 40 per cent of that years GDP for the whole nation - at a time when Britain was the richest nation on Earth.

The Government borrowed so much money to do it, it wasnt until 2015 that the debt had been paid off.

The effects were huge for Clifton - with a massive amount of cash suddenly in their pockets, the rich merchants of Bristol sparked a big boom in development in Clifton, creating the suburb of grand Georgian houses we see today.

The plantation owners didnt lose their plantations, or indeed their slaves. Those people working in Clifton on Union Island might have celebrated their freedom, but the deal was that they still had to work for up to five years for free.

And then, on an island with nothing much except cotton plantations, the freed slaves continued on as share-croppers - their homes and land were still owned by the Spann family, who now employed them rather than enslaved them.

In 1850, Clifton and Ashton and Union Island itself were sold by the Spann family to a local businessman called Major Collins, and 13 years later leased to Charles Mulzac, an aggressive sharecropper of French descent.

The people of Clifton and Ashton in Bristol arent particularly noted for their rebellious natures - not compared with the likes of Stokes Croft, St Pauls or perhaps Easton.

But Clifton and Ashton on Union Island has always been a place of fierce independence.

In the late 19th century the locals rebelled against the conditions of their sharecropping, and won significant improvements. Many headed off to work on the whaling boats, and when Union Island was eventually bought back by the British Empire in the 1920s, the inhabitants of Ashton and Clifton found themselves, for the first time - in theory at least - on a level footing with those living in Ashton and Clifton in Bristol. They were British citizens and were even given the vote.

Union Island is part of the island chain nation of St Vincent and the Grenadines, and is the most southerly of those. The island nation of Grenada - which has such close links with the US, even though its a member of the Commonwealth - is close by, and can be seen from the hill above Ashton on a clear day.

In the 1970s, the people of Clifton and Ashton were so fed up with being the forgotten part of their country, that they rose up in rebellion and demanded to be allowed to breakaway from St Vincent and the Grenadines, and instead become part of the nation of Grenada.

Their country sent its own troops to the island - and soldiers fought the locals and patrolled the streets to put the insurrection down.

Since then, there has been positive change. The US Navy came to help build better harbour facilities, and investment in communications and the internet has helped the people of Clifton and Ashton embrace their new opportunities for tourism.

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The story of 'the other Clifton and Ashton' and their remarkable links to Bristol - Bristol Post

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Mass migration to udalenku will double the number of leaks – The KXAN 36 News

Posted: at 4:59 am

the Amount of leakage of corporate data, related to the mass transfer of Russians to a remote format may increase in 2-3 times. How do you think interviewed by Izvestia experts, personal computers of employees to be more secure than office, and at home no one will be protected from spam and phishing attacks.

According to company Internet search, already from March 16 were recorded 4-fold increase in the number of phishing emails. Of course cybercriminals couldnt miss such a moment and email filled messages that contain malicious codes that allows you to make various offenses, from hacking social network account to encrypt the server of the company, said the head of Internet search Igor Bederov.

in solidarity With them in Group-IB. Attackers can pull sensitive data through the use of letters of trompe loeil, which allegedly contained important information on the topic of coronavirus for example, the abolition of travel.

At the same time vulnerable, even home computers with a configured VPN access and special systems to prevent leakage. According to the head of the Zecurion analytical center Vladimir Ulyanov, corporate data can be easily stolen due to the lack of visual control on the part of colleagues and cameras. The probability of leaks increases the transfer of communications when users begin to share work documents via personal email and instant messengers.

Additional risks arise when the employee changes the configuration or uses the programs, which were not agreed with administrators. Corporate systems, for example, may threaten a program downloaded from torrent trackers, says Director of cybersecurity Rambler Group Ilya Zuev.

to reduce the risk of leaks to a minimum, experts recommend that organizations install on home computers antivirus, configure a VPN connection with two factor authentication, and update all programs and equipmente, which is used for remote access. Not be amiss to segment the network that will help protect our corporate infrastructure, and share access rights.

Text: To.Hi-tech

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Mass migration to udalenku will double the number of leaks - The KXAN 36 News

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Psoriasis: Types, Pictures, Causes, Symptoms, Treatments …

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Alwan, W., and F.O. Nestle. "Pathogenesis and Treatment of Psoriasis: Exploiting Pathophysiological Pathways for Precision Medicine." Clin Exp Rheumatol 33 (Suppl. 93): S2-S6.

Arndt, Kenneth A., eds., et al. "Topical Therapies for Psoriasis." Seminars in Cutaneous Medicine and Surgery 35.2S Mar. 2016: S35-S46.

Benhadou, Fairda, Dillon Mintoff, and Vronique del Marmol. "Psoriasis: Keratinocytes or Immune Cells -- Which Is the Trigger?" Dermatology Dec. 19, 2018.

Conrad, Curdin, Michel Gilliet. "Psoriasis: From Pathogenesis to Targeted Therapies." Clinical Reviews in Allergy & Immunology Jan. 18, 2015.

Dowlatshahi, E.A., E.A.M van der Voort, L.R. Arends, and T. Nijsten. "Markers of Systemic Inflammation in Psoriasis: A Systematic Review and Meta-Analysis." British Journal of Dermatology 169.2 Aug. 2013: 266-282.

Georgescu, Simona-Roxana, et al. "Advances in Understanding the Immunological Pathways in Psoriasis." International Journal of Molecular Sciences 20.739 Feb. 10, 2019: 2-17.

Greb, Jacqueline E., et al. "Psoriasis." Nature Reviews Disease Primers 2 (2016): 1-17.

Kaushik, Shivani B., and Mark G. Lebwohl. "Review of Safety and Efficacy of Approved Systemic Psoriasis Therapies." International Journal of Dermatology 2018.

National Psoriasis Foundation. "Systemic Treatments: Biologics and Oral Treatments." 1-25.

Ogawa, Eisaku, Yuki Sato, Akane Minagawa, and Ryuhei Okuyama. "Pathogenesis of Psoriasis and Development of Treatment." The Journal of Dermatology 2017: 1-9.

Stiff, Katherine M., Katelyn R. Glines, Caroline L. Porter, Abigail Cline & StevenR. Feldman. "Current pharmacological treatment guidelines for psoriasis and psoriaticarthritis." Expert Review of Clinical Pharmacology (2018).

Villaseor-Park, Jennifer, David Wheeler, and Lisa Grandinetti. "Psoriasis: Evolving Treatment for a Complex Disease." Cleveland Clinic Journal of Medicine 79.6 June 2012: 413-423.

Woo, Yu Ri, Dae Ho Cho, and Hyun Jeong Park. "Molecular Mechanisms and Management of a Cutaneous Inflammatory Disorder: Psoriasis." International Journal of Molecular Sciences 18 Dec. 11, 2017: 1-26.

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US Dermatologists Anticipate the Future of Atopic Dermatitis to Mirror that of the Over-Crowded Psoriasis Market – Daily Local News

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EXTON, Pa., March 17, 2020 /PRNewswire/ --The past decade has ushered in an array of new treatment options for moderate-to-severe plaque psoriasis, providing dermatologists with more than they bargained for and often times making it difficult to compare efficacy across medications. Thus, it has become crucial for companies to differentiate their assets both within and outside their drug class whether it be through head-to-head clinical trials, patient assistance programs, or building a dermatology portfolio to establish trust and a relationship as a respected partner in the field.

A noteworthy example of a company differentiating themselves from the pack is AbbVie, particularly with the launch of their third-in-class IL-23 inhibitor, Skyrizi, in psoriasis. According to the latest quarterly report included in Spherix's RealTime Dynamix: Plaque Psoriasis (US) service, brand share for fellow IL-23 inhibitor, Janssen's Tremfya, as well as the IL-17 inhibitors, Novartis' Cosentyx and Eli Lilly's Taltz, have remained relatively flat, while AbbVie's newest market entrant has experienced exponential growth since its April 2019 introduction. Impressively, nearly two-thirds of the 101 US dermatologists surveyed selected Skyrizi as their most preferred IL-23 inhibitor if limited to just one for the treatment of psoriasis, despite Tremfya's almost three-year tenure on the market.

Skyrizi's early success in psoriasis is likely attributed to a multitude of factors. Dermatologists report frequent contact with Skyrizi representatives, elevated satisfaction with the Skyrizi Complete program, high awareness of AbbVie's head-to-head post-marketing study demonstrating superiority over Cosentyx on skin clearance, and overall greater perceived efficacy compared to other alternate mechanism of action agents. Furthermore, the manufacturer is beginning to build onto their already well-received Humira legacy, expanding their dermatology portfolio an approach many big players in the field are partaking in.

AbbVie, Amgen, Eli Lilly, Janssen, and Novartis all own commercial products for the treatment of psoriasis as well as pipeline assets in atopic dermatitis (AD), with Pfizer holding pipeline assets in both indications. With only one biologic (Regeneron/Sanofi's Dupixent) currently FDA approved for the treatment of moderate to severe AD and a myriad of companies (aside from those listed above) with agents in the pipeline, the future advanced systemic market in AD has the potential to mirror the current psoriasis biologic landscape.

According to the Q1 2020 report included in Spherix's RealTime Dynamix: Atopic Dermatitis (US)service, 85% of surveyed dermatologists foresee the AD market emulating that of the crowded psoriasis market. Respondents also report a biologic/small molecule patient candidacy pool that is substantially larger than those currently treated with Dupixent and one that is comparable to the biologic-treated patient load in psoriasis.

Despite anticipated resemblances between the two markets, AD patients will likely be treated with more small molecule options, specifically JAK inhibitors. With the oral JAK inhibitors' (Lilly's Olumiant/baricitinib, Pfizer's abrocitinib, and AbbVie's Rinvoq/upadacitinib) projected launches around the corner, their location in the AD treatment paradigm will be key to uptake. Currently, one-half of dermatologists report it is unlikely these agents will be used prior to biologics in AD, which is how many prefer to utilize BMS' Otezla for the treatment of moderate to severe psoriasis. Instead, dermatologists will likely follow in the footsteps of rheumatologists, where both Pfizer's Xeljanz and AbbVie's Rinvoq currently play in-line with the injectable biologics in RA.

Dermatologists also await the approval of topical JAK inhibitors for the treatment of AD (specifically Incyte's topical ruxolitinib and LEO's topical delgocitinib) and anticipate using these agents prior to oral JAK inhibitor use, in less severe patients, and for short-term flare management.

With a plethora of pipeline agents with the same mechanism of action and comparable efficacy, it comes down to the strategies these manufacturers are implementing across dermatology to build trust with prescribers around their brands, hence the creation of a dermatology portfolio. Spherix will be closely tracking products in development as well as newly launched brands in both markets through the RealTime Dynamixservices.

About RealTime DynamixRealTime Dynamix: Plaque Psoriasis (US) is an independent service providing strategic guidance through rapid and comprehensive quarterly reports, which include psoriasis market trending, launch tracking, and a fresh infusion of unique content with each wave.

A parallel service, RealTime Dynamix: Atopic Dermatitis (US), tracks the evolution of the US atopic dermatitis market on a quarterly basis.

About Spherix Global InsightsSpherix Global Insights is a hyper-focused market intelligence firm that leverages our own independent data and expertise to provide strategic guidance, so biopharma stakeholders make decisions with confidence. We specialize in select immunology, nephrology, and neurology markets.

All company, brand or product names in this document are trademarks of their respective holders.

For more information contact:Lynn Price, Immunology Franchise HeadEmail:info@spherixglobalinsights.comwww.spherixglobalinsights.com

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US Dermatologists Anticipate the Future of Atopic Dermatitis to Mirror that of the Over-Crowded Psoriasis Market - Daily Local News

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Assessment of the Patient Acceptable Symptom State (PASS) in psoriatic arthritis: association with disease activity and quality of life indices -…

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OBJECTIVE:

The aim of this study was to evaluate the discriminant capability of the Patient Acceptable Symptom State (PASS) according to disease activity, remission/low disease activity indices and quality of life indices in patients withpsoriatic arthritis(PsA).

Consecutive patients with PsA were enrolled in this cross-sectional study. At each visit, the patients underwent a complete physical examination and their clinical/laboratory data were collected. Disease activity was assessed using the Disease Activity Score forPsoriatic Arthritis(DAPSA) and remission/low disease activity using the DAPSA minimal disease activity (MDA) and very low disease activity (VLDA) criteria. ThePsoriatic ArthritisImpact of Disease (PsAID) and the Health Assessment Questionnaire-Disability Index scores were also collected. Finally, PASS was assessed by asking all patients to answer yes or no to a single question.

Patients who answered yes to PASS showed a significantly better overall mean DAPSA score than those who were not in PASS. Furthermore, patients in PASS showed a significantly lower level of systemic inflammation, lower Leeds Enthesitis Index score, a significantly lower impact of disease (PsAID), lower pain and better function than patients who answered no to PASS. A moderate to good agreement was found between PASS, MDA, DAPSA low disease activity and PsAID score 4. Good sensitivity and specificity were found with PASS with respect to DAPSA low disease activity, and although PASS is sensitive in the identification of patients with MDA, DAPSA remission and VLDA it lacks of specificity.

This study showed that PASS might be used as an alternative to determine disease activity in patients with PsA in real clinical practice, mainly in patients with low disease activity according to DAPSA criteria.

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Assessment of the Patient Acceptable Symptom State (PASS) in psoriatic arthritis: association with disease activity and quality of life indices -...

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Scientists Call for Fusion Power Plant in the United States – Futurism

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Pilot Program

In an ambitious push to develop and implement nuclear fusion power, a team of 300 researchers just published a massive new report that lays out exactly what the scientific community needs and what it should prioritize to get the ball rolling.

The main goal of the report, according to an MIT press release, is to develop a shared, functional nuclear fusion power plant in the U.S. by the end of the decade the most ambitious and concerted call-to-arms for nuclear physicists,arguably, that the field has seen in years.

Theres a lot that needs to happen before that pilot fusion plant gets built if scientists had already conquered the challenges of practical nuclear fusion then the report wouldnt have been necessary.

This is the first time in a generation when the fusion community has been called upon to self-organize and figure out its highest priorities for getting from fusion science to fusion energy, Bob Mungaard, CEO of Commonwealth Fusion Systems, said in the release. How we can get ready, with data, experience, test facilities the things that are needed to support the science, and eventually an industry.

Over the next eight months, the team behind the report plans to formalize a series of recommendations for the Department of Energy on how to best pursue fusion energy.

Its something a lot of folks in Congress are interested in, said University of California, Los Angeles researcher Troy Carter.

READ MORE: Fusion researchers endorse push for pilot power plant in US [MIT Newsroom]

More on nuclear fusion: Expert: Im 100 Percent Confident Fusion Power Will Be Practical

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NASA Fixes Mars Lander By Telling It to Hit Itself With a Shovel – Futurism

Posted: at 4:57 am

Percussive Maintenance

NASAs InSightlander, which is currently on the surface of Mars, has faced some unexpected problems during its mission to explore and study the planet.

Namely, a digging probe that was built to burrow beneath the surface like a jackhammer got stuck because Mars soil is clumpier than scientists expected,PopularScience reports.

After a few failed attempts to get it out, NASA had to get a bit creative. Ultimately, it freed the probe up by giving it a solid thwack with InSights shovel.

NASA expected its probe, dubbed the mole, to dig its way through sand-like terrain. But because the Martian soil clumped together, the whole apparatus got stuck in place.

Programming InSights robotic arm to land down on the mole was a risky, last-resort maneuver, PopSci reports, because it risked damaging fragile power and communication lines that attached nearby. Thankfully, engineers spent a few months practicing in simulations before they made a real attempt.

With tentative results that the mole is working again, NASA hopes to again task it with burrowing beneath the surface of Mars.

Once its down there, it will hopefully be able to complete its research mission: analyzing temperature fluctuations inside the Red Planet in an attempt to understand how similar Mars core is to that of Earth.

READ MORE: At long last, NASAs probe finally digs in on Mars [Popular Science]

More on InSight: NASA Isnt Sure Whats Wrong With Its InSight Mars Lander

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We Talked to Someone Who Got the Experimental Coronavirus Vaccine – Futurism

Posted: at 4:57 am

This past Monday, Seattle-area Microsoft network engineer Neal Browning became the second-ever person to be injected with the experimental coronavirus vaccine developed by Moderna.

Later this week, we caught up with Browning to chat about how he ended up here, how his daily routine has changed since taking the vaccine, and what it feels like to take part in medical history.

This interview has been lightly edited and condensed for clarity.

Futurism: Why did you volunteer to take part in this trial?

Neal Browning: Because science, facts, and medicine are important parts of modern life. I tell my three daughters they have to go get their vaccinations and flu shots, I am no different when leading by example. If I am healthy and can help take part in trying to reduce the pain, suffering and deaths associated with this pandemic, I would be remiss not to.

Logistically, howd you actually get involved?

A friend on Facebook referred me to the program, I looked into it and felt like I could make a difference if I took part.

What did it feel like, emotionally, as you prepared to get your first dose?

I was actually pretty relaxed. They had just taken my blood pressure and pulse before to make sure all was well, I was at about 72bpm pulse. I donate blood regularly, and needles dont bother me. There is no dead or even weakened virus in this vaccine, and while it had never been tested on any animal and I was the second to get it, I knew and accepted the risks.

Did you notice any side effects, or anything else, after you took the vaccine?

So far, near zero. The injection didnt hurt at all, and there was only a slight tightness in my arm from the vaccine being inserted. The following morning, there was very mild ache in the muscle at the injection site, but once I moved around and got blood flowing, it disappeared entirely within five minutes.

Are you at home, or are you being held for observation?

Im at home, but have a daily log to fill out, recording any symptoms at all, even if I dont think they are related to the vaccine, as well as my temperature daily. Ill return to the research location once a week for blood draws to analyze how my body is reacting.

Whats your living situation currently like?

I live with my fianc, and 50percent of the time we have my two daughters and her one daughter. We wash hands regularly, dont associate outside the home, and limit exposure by not going to public places except when absolutely necessary.

What happens next for you and the other participants as they test whether the vaccine worked?

We continue daily logs, and go get blood taken for the next four weeks. On week four, we will get a second vaccine injection, then go through an identical 4 weeks of weekly blood draws and daily logs.

Are you in any risk groups for the coronavirus, and did that factor into why they selected you?

No, that would be the phase 2 group, this group was tightly controlled, all between 18 and 55 years old, very healthy, and they went over our medical history quite in depth and rigorously to ensure there were not underlying health issues that could interfere at this first testing phase.

Do you know anyone whos been personally affected by the outbreak?

Yes, I heard that one of my old co-workers daughter had (she is in her early 20s) and had a rough go of it, but is recovered and ok now.

Is there anything else you think our readers should know?

Yes do not treat this lightly. If we overreact, we might never know if we did. If we under-react, we will cost a lot of lives needlessly. Those saying it is just the flu, or that they are young and wont be hurt you can be infected and contagious for over a week before you have symptoms. Think about your parents, friends, grandparents, everyone you are spreading this to unintentionally then they do the same. This is why we are in the place we are now. Limit social interactions outside of your home, wash your hands, and this will end sooner, and with less loss of life.

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The Second Man to Walk on the Moon Has Some Quarantine Advice – Futurism

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Berger Time

When Ars Technica senior space reporter Eric Berger asked Buzz Aldrin, the second man to have walked the Moon in 1969, what he would do while practicing social distancing during the coronavirus outbreak, Aldrin had some choice words: Lying on my ass and locking the door.

Aldrin is familiar with the concept of spending time in quarantine. After the Apollo 11 Command Module landed, he, along with commander Neil Armstrong and module pilot Michael Collins, had to spend three long weeks in quarantine to make sure no nasty bugs from space could spread on our planet.

The three men were first moved to the Mobile Quarantine Facility, a converted Airstream trailer pretty tight quarters for three adults. They were then airlifted to a secure building called the Lunar Receiving Laboratory. Years later, once the Moon was proven to be barren of life, NASA discontinued this practice after Apollo 14.

When Berger asked Aldrin for some advice for the millions of people currently self-isolating at home, the now 90-year-old former astronaut reminisced of his own time in quarantine. Well, Mike Collins and I used to exercise and jog a little bit around the hallway.

Aldrin also questioned if his and his teams temporary home was really capable of holding microbes in.

We looked at this one crack in the floor, and there were ants crawling in and out, Aldrin said.

Most of the rest of his time, he said, was spent doing paperwork.

READ MORE: Buzz Aldrin has some advice for Americans in quarantine [Ars Technica]

More on quarantine: As Coronavirus Rages, Elon Musk Refuses to Close Tesla Factory

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