Daily Archives: March 24, 2020

eTheRNA Launches an International Consortium and Starts Development of Cross-strain Protective CoV-2 mRNA Vaccine for High Risk Populations – BioSpace

Posted: March 24, 2020 at 5:54 am

NIEL, Belgium, March 24, 2020 /PRNewswire/ -- eTheRNA Immunotherapies nv ('eTheRNA' or 'The Company'), a clinical-stage company developing vaccines and immunotherapies from its proprietary mRNA TriMix platform, today announced that a consortium has been formed with North American and European partners to develop a novel mRNA vaccine against CoV-2 and preclinical development has started. Chinese partners may be added in the consortium in due course.

Administered intranasally, the proposed vaccine is intended primarily for high risk populations such as healthcare workers and families of confirmed cases. It is also designed to be protective against future variations of the virus by targeting conserved epitopes from the whole CoV-2 genome. eTheRNA and its partners EpiVax, Nexelis, REPROCELL and CEV* have extensive experience in the mRNA vaccine field and this will help accelerate progress towards clinical trials with patient enrolment expected in early 2021.

Steven Powell, eTheRNA's CEO, explained the aims of the consortium: "Viral variation means traditional medicinal and preventive vaccine approaches may fall short when confronted with seasonal or outbreak situations. A vaccine to defend against current and future outbreaks of coronavirus and other respiratory viral pathogens should be robust against viral genome changes, provide a platform that enables rapid introduction of a new viral target, be easy and safe to administer and be scaleable and suitable for stockpiling. The innovative vaccine program we have started with our partners incorporates all of these essential features."

Traditional vaccines are based on generating an antibody response to outer surface viral protein targets. However, viral variation may greatly reduce the effectiveness of this approach. For example, the SARS-CoV-2 outer surface spike protein (S) is less than 40% homologous to SARS-CoV-1. Furthermore, it has also been reported in several cases that vaccines with suboptimal antibody response (too low or not neutralizing) have facilitated viral entry and been linked to disease enhancement.

The eTheRNA consortium's approach selects conserved epitopes from the whole viral genome. Creating a vaccine that mounts a strong cellular (T cell) based response against these epitopes offers a better chance to overcome viral variability. Intranasal delivery has been chosen since the mucosa of the upper respiratory tract are the immune system's primary line of defense. A strong nasal T cell effector and memory response is claimed to fight viral replication, colonization of the lung and thus disease. mRNA has also been demonstrated to induce strong T cell responses by intranasal delivery.

The development programme has been initiated and is focused on a vaccine candidate that integrates 3 different technologies:

"While valuable initiatives and strong support are being deployed into the development of medicinal and vaccine solutions for immediate use against SARS-CoV-2, it is also important that development of solutions for the longer term should also start as soon as possible," concluded Powell. "Our target is to bring this into clinical testing in early 2021."

Information for editors

About eTheRNA immunotherapies

eTheRNA immunotherapies is a clinical-stage company developing innovative immunotherapies from its proprietary mRNA TriMix platform. eTheRNA was established in January 2013 as a spin-off from the VUB university in Belgium and is developing products for the treatment of cancer and infectious disease.

About TriMix

The TriMix platform, on which eTheRNA's immunotherapies are based, comprises three mRNAs encoding proteins (caTLR4, CD40L and CD70) that work to deliver optimal activation of dendritic cells. These cells behave as immune response mediators and mobilize the immune system to attack cancer cells through inducing a T-cell response. Clinical proof of concept for TriMix-based immunotherapies has been established through an extensive dataset demonstrating clinical benefits in advanced melanoma patients.

About EpiVax

EpiVax is a 21-year old privately held biotechnology company located in Providence, Rhode Island. Scientists at EpiVax, led by co-founders Annie De Groot, MD and Bill Martin, lead in the fields of immunogenicity risk assessment and computational vaccinology with expertise in T cell epitope prediction, immune modulation, and rapid vaccine design. EpiVax's broad portfolio of projects includes vaccines and immunotherapies for infectious diseases, autoimmunity and cancer. EpiVax's proprietary in silico immunogenicity screening toolkits for therapeutics and vaccines, ISPRI and iVAX, are employed in advancing the research of a global roster of companies. Visit http://www.epivax.com for more information.

About Nexelis

With unrivaled expertise in immunology on both sides of the client/CRO relationship, and operating sites in North America (East and West Coast) and Europe, Nexelis is a leading provider of assay development and advanced laboratory testing services in the infectious diseases, metabolic diseases, and oncology fields. Our versatile team of scientists, working with our advanced technology platforms, were instrumental in the development, qualification, validation, and large-scale sample testing of assays that supported the FDA filing of almost 100 new molecular entities, including blockbuster vaccines, anti-viral drugs, and immunotherapy, gene and cell therapy products. Visit http://www.nexelis.com for more information.

About REPROCELL

REPROCELL was established in 2003 to accelerate medical research via cutting-edge stem cell and human tissue-based technologies, including the use of novel transfection reagents and RNA-based methods for the generation of induced pluripotent stem cells. REPROCELL has further diversified its portfolio of products and services to include predictive drug discovery services in human fresh tissues, technologies for the manufacture of bioengineered human tissues, industry-leading gene editing technology and one of the largest commercial repositories of ethically sourced human tissue. Visit http://www.reprocell.com for more information.

About CEV

The Centre for the Evaluation of Vaccination (CEV) of the University of Antwerp, headed by Prof. Pierre Van Damme, is a clinical trial centre specialized in the conduct of vaccine trials. It has performed Phase I until Phase IV clinical trials in all age groups. The CEV is internationally known for its professional and qualitative vaccine clinical trial facility and organisation and is therefore a regular partner in vaccine clinical trials, i.e. for EU funded clinical trials, for investigator-driven vaccine trials as well as for industry funded clinical trials. For more information visit https://www.uantwerpen.be/en/research-groups/centre-for-evaluation-vaccination/

Contact information

media@etherna.be

Or

Richard HayhurstRHAprMobile +44 (0)7711-821-527richard@rhapr.eu

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SOURCE eTheRNA

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eTheRNA Launches an International Consortium and Starts Development of Cross-strain Protective CoV-2 mRNA Vaccine for High Risk Populations - BioSpace

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Trance (2020) – IMDb

Posted: at 5:53 am

Learn more More Like This

Action | Drama | Thriller

The story revolves around the clash between Ayyappan, a senior police officer who serves at the Attappadi Police Station and Havildar Koshi, who comes to the village with a motive.

Director:Sachy

Stars:Biju Menon,Prithviraj Sukumaran,Renjith

Crime | Mystery | Thriller

Samuel uses his forensic skills and discovers breakthroughs in a serial killing case as further victims are added to the list. Shikha teams up with Samuel and uncovers evidence that might lead to the killer's identity.

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Stars:Dhanesh Anand,Rony David,Reba Monica John

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Neena is a French teacher and single parent to Nikitha, who is obsessed with the concept of an arranged marriage. Their life changes when a retired army man and another young man come to stay at the apartment.

Director:Anoop Sathyan

Stars:Shobana,Suresh Gopi,Kalyani Priyadarshan

Drama | Romance | Thriller

A carefree youngster`s life takes an interesting turn after he meets the girl of his dreams.

Director:Desingh Periyasamy

Stars:Dulquer Salmaan,Ritu Varma,Rakshan

Crime | Mystery | Thriller

The police are on the trail of a serial killer, but with the victims being fellow officers, will they be able to catch the killer and solve the case in time?

Director:Midhun Manuel Thomas

Stars:Kunchacko Boban,Jinu Joseph,Unnimaya Prasad

Comedy | Drama | Thriller

A famous actor needs to renew his driver's licence, and the motor vehicle agent is a fan of his, but a series of misunderstandings causes a great deal of friction.

Director:Jean Paul Lal

Stars:Prithviraj Sukumaran,Mia George,Suraj Venjaramoodu

Comedy | Drama

Sleevachan gets married in hopes of having someone to care for his aging mother. He is, however, oblivious of the idiosyncrasies of a relationship. Trouble comes soon after he takes matter to his own hands.

Director:Nissam Basheer

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Action | Drama | Thriller

The story follows an episode in the life of Boss, a quick-witted, sharp financier in Kerala's film industry.

Director:Ajai Vasudev

Stars:Mammootty,Meena,Joy Badlani

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An ordinary suburban girl suddenly disappears, leaving her loved ones in a desperate search as she must face the ultimate battle - the one for her life.

Director:Mathukutty Xavier

Stars:Anna Ben,Lal,Noble Babu Thomas

Action | Adventure | Drama

Set in the pre-independent India, Aloshi returns from the war to his estranged family and childhood love, only to find his elder brothers taking the side of a ruthless business man to overthrow their father.

Director:Amal Neerad

Stars:Fahadh Faasil,Jayasurya,Lal

Drama | Mystery | Thriller

Aravind is informed that something unexpected has happened to his family and has to reach the hospital immediately. What awaits him comes as a shock as he is soon sucked into a miasma of questions that he has to fight to find the answers.

Director:Prasobh Vijayan

Stars:Jayasurya,Shruti Ramachandran,Vijay Babu

Comedy

Sameer, an expatriate and Eldho, a school peon. During one of Sameer's vacation, both of their lives take an intriguing turn because of the misuse of social media.

Director:Emcy Joseph

Stars:Suraj Venjaramoodu,Soubin Shahir,Vincy Aloshious

Story revolves around Viju Prasad, a motivational trainer based out of Kanyakumari, and the growth and setbacks he faces in different phases of his life.

Cumulative Worldwide Gross: $427,707

Runtime: 170 min

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Trance (2020) - IMDb

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Amazon.com: Watch Trance | Prime Video

Posted: at 5:53 am

(Contains no "spoils") I was curious about James McEvoy & looked at some movies & trailers. Decided on TRANCE & very, very happy with choice!!!

I had anticipated more of an action/thriller, but TRANCE is even better...more of a psychological suspense!!! The plot "almost" revolves around an art heist, but, don't think..."oh, another 'art heist caper' film", because it's very far from that. The art heist itself could almost be another character.

The writing and performances are all masterful! James McAvoy is the magnetic lead, playing Simon, who stole the painting (I'm not giving anything away here), received a fierce blow to the head from Frank, a wicked bad-ass, very well done by Vincent Cassei, which results in Simon losing his memory of what he did with the painting. Giving a bewitching & captivating performance is Rosario Dawson, playing the hypnotherapist Simon is brought to, in order to try hypnotherapy to coax & recover his memory, and, therefore, the painting....

This is where TRANCE really begins playing with viewers' minds, teasing and tantalizing us with each step Simon takes!!! Here's what TRANCE'S plot is really all about...memories: real, "suggested" perhaps even false memories & suppressed memory. This recipe proves deliciously entertaining!!! For we're taken along on a twisting, turning, taunting, engrossing ride of what's real & what's imagined!!! While it may sound extremely confusing, the brilliant writer(s) of TRANCE and the director, Danny Boyle, "almost" answer one question at a time during each new scene as it unfolds...(or do they)?!

TRANCE builds & builds the suspense throughout the film, culminating in an invigorating thrill throughout, tying it all together neatly & very satisfyingly for the viewer. TRANCE is everything & more a psychological suspense should be and it's exceptional!!

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Amazon.com: Watch Trance | Prime Video

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How to Wake Up From the Trance of Unworthiness – Good News Network

Posted: at 5:53 am

The Lesson: Though were rarely conscious of it, we continually evaluate ourselvesand are convinced that something is wrong with us. In this audio session, acclaimed psychotherapist and Buddhist practitioner Tara Brach takes us through the process of waking up from a mental state we might not realize were caught up in; and once we can let go of constant self-judgement, we can actually live up to our potential. Join her as she explores the factors which lead to the trance of unworthiness, how we can identify it as it happens, break free of the cycle of self-doubt, andmost importantlydevelop trust in our own natural inner goodness.

Notable Excerpt: Ive found that usually theres a gap between our standard of how we should be, and our own experience, and its that gap which makes us feel like were not okay. The number one deepest regret of the dying are that they didnt live true to themselvesthat they lived according to the expectations of others, of the shoulds and I thought it would be tremendously useful for people to have a guided passageway through and beyond the forces that guide us to live unfaithfully to ourselves.

The Speaker: Tara Brach is an American psychologist, author, and proponent of Buddhist meditation. She is a guiding teacher and founder of the Insight Meditation Community of Washington DC, although Dr. Brach teaches her Wednesday night meeting in Bethesda, Maryland.

Download Tara Brachs audio session The R.A.I.N. Meditationand browse her other audio meditationsat the Sounds True digital library.

Podcast: Sounds True was founded in 1985 by Tami Simon with a clear mission: to disseminate spiritual wisdom and to wake up the world. Since starting out as a project with one woman and her tape recorder, the group has grown into a multimedia publishing company with more than 80 employees, a library of more than 1,500 titles featuring some of the leading teachers and visionaries of our time, and an ever-expanding family of listeners from across the world. If you want to learn more, you can check out their YouTube, Facebook, Instagram, or website.

(LISTEN to the inspiring lecture below)

Good Advice? Share It With Your FriendsAnd Check OutMore On Our Good TalksPage

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Every concert you can livestream on March 23 during the coronavirus outbreak – CNET

Posted: at 5:52 am

Melissa Etheridge

Amid the coronavirus outbreak, the Centers for Disease Control and Prevention and the US government have encouraged social distancing to slow the spread of the sickness. This has led to the cancelation of many large cultural and sports gatherings.

An increasing number of artists are still trying to provide experiences for fans without sacrificing safety. Here are all the shows you can stream now.

"Last night a DJ Saved My LIfe!" On Saturday, DJD-Nice Hosted An Instagram Live Social Distancing Uplift Partyfeaturing everybody's favorite, uplifting music, an energetic vibe and an overwhelming feeling of unity. 100,000 people showed up. On Sunday 160,000 people showed up. Everyone showed up from Ava DuVernay to former Vice President Joe Biden. From Justin Timberlake to Will Packer Jr. From Bernie Sanders to former First Lady Michelle Obama to Dj Khaled to Janet Jackson and Rihanna. He's back at it today. Tune in for another multi-hour raging dance party! Let's hope he keeps this going every night.

#DniceHomeSchoolpresents Quest Lovers Rock: Sloppy Seconds. For those of you that don't know him, Questlove is the legendary drummer for The Roots and drummer in the in-house band for The Tonight Show Starring Jimmy Fallon After turning in a killer DJ set Sunday night watched by more than 100,000 people, he's back at it today spinning killer R&B tunes and deep cuts. Tune in for another multi-hour DJ set! Let's hope he keeps this going every night.

Miley Cyrus hosts a Monday-Friday hourlong live stream "connecting w/ special guests discussing how to stay LIT in dark times" in her new series #BrightMinds.

Chris and Rich Robinson of The Black Crowes will be performing a special set on NPR Music #tinydesk

Armin van Buuren's venerable A State of Trance brand is launching a live stream entitled "Beat the Silence."Trance fans can tune in via ASOT's Twitch, Facebook and YouTube channels, with music streaming daily. #ASOT

Garth Brooks has announced he will play a concert on his weekly "Inside Studio G" Facebook series tonight. The show will be just Brooks and a guitar (and possibly wife Trisha Yearwood) taking requests for up to an hour. SiriusXM will also broadcast the show on The Garth Channel (ch. 55), Brooks' exclusive SiriusXM channel.

Diplo has been spinning a minimum of a two hour DJ set every single night since the quarantine started. Tune In!

Chris and Rich Robinson of The Black Crowes will be performing a special set on NPR Music #tinydesk

Armin Van Buuren Ultra Music Festival 2020 (Virtual Audio Festival)

Allen Stone performs for the twice daily Billboard Live At-Home series.

Tune in everyday. at 1 p.m. ET for Sofi Tucker's daily live stream

Tune in everyday. at 1 p.m. ET for Fred Hersch's daily live stream of jazz music.

Conan Gray will be hosting a live digital party all weekend long to celebrate the release of his debut studio album Kid Krow Friday, March 20. Gray plans to kick off the festivities Thursday at 8:30 p.m. PT with an Instagram Live session, followed by a YouTube live stream Friday at 3 p.m. PT, a Twitter Q&A Saturday at 1 p.m. PT and ending with a Reddit AMA Monday at 10 a.m. PT.

Third Man Records is hosting "Third Man Public Access," a series of live-streamed performance from their Blue Room in Nashville, TN.

Kontor Live is hosting "DJ Delivery Service," a daily series of live-streamed performance from Kontor Headquaters.

Kontor Live is hosting "DJ Delivery Service," a daily series of live-streamed performance from Kontor Headquaters.

Christine and the Queens will perform on their Instagram Live for "Together, At Home: WHO-Global Citizen Solidarity Sessions." #TogetherAtHome

No Take Away Shows during lockdown? No problem, here are the Stay Away Shows! We want our entire community and all music lovers to have access to their favorite artists and discover new talents during the confinement period. That's why we're launching the Stay Away Shows. Every day, at 7pm Paris time, 2pm NYC time, 11am LA time, on our instagram, friends from the Blogothque will come and play a live show with a lot of surprises. Please, stay home, stay safe, and see you tomorrow!

Jason Crosby, piano virtuoso, hosts his daily live stream.

Miley Cyrus hosts a Monday-Friday hourlong live stream "connecting w/ special guests discussing how to stay LIT in dark times" in her new series #BrightMinds.

Rolling Stone's In My Room Series

Years & Years will perform on their Instagram Live for "Together, At Home: WHO-Global Citizen Solidarity Sessions." #TogetherAtHome

Brandy Clark will perform on her Instagram Live for "Together, At Home: WHO-Global Citizen Solidarity Sessions." But stay tuned later that day for the first installment of Brandy's Book Club at 4 p.m. PT when she'll talk about Glennon Doyle's book Untamed on her Instagram Live. #TogetherAtHome

Armin van Buuren's venerable A State of Trance brand is launching a live stream entitled "Beat the Silence."Trance fans can tune in via ASOT's Twitch, Facebook and YouTube channels, with music streaming daily. #ASOT

URL Tour

Madison Beer live streams from Billboard Live At-Home

Perpetual Groove will broadcast the electric portion of their May 30, 2015 concert at The Georgia Theatre in Athens Georgia that ended a two-night stand at the venue.

Armin van Buuren's venerable A State of Trance brand is launching a live stream entitled "Beat the Silence."Trance fans can tune in via ASOT's Twitch, Facebook and YouTube channels, with music streaming daily. #ASOT

The UK's No.1 jive and swing band!

Picture This will perform on their Instagram Live for "Together, At Home: WHO-Global Citizen Solidarity Sessions." #TogetherAtHome

Armin van Buuren's venerable A State of Trance brand is launching a live stream entitled "Beat the Silence."Trance fans can tune in via ASOT's Twitch, Facebook and YouTube channels, with music streaming daily. #ASOT

Live from his pad in San Francisco, CA

"Last night a DJ Saved My LIfe!" On Saturday, DJD-Nice Hosted An Instagram Live Social Distancing Uplift Partyfeaturing everybody's favorite, uplifting music, an energetic vibe and an overwhelming feeling of unity. 100,000 people showed up. On Sunday 160,000 people showed up. Everyone showed up from Ava DuVernay to former Vice President Joe Biden. From Justin Timberlake to Will Packer Jr. From Bernie Sanders to former First Lady Michelle Obama to Dj Khaled to Janet Jackson and Rihanna. He's back at it today. Tune in for another multi-hour raging dance party! Let's hope he keeps this going every night.

Melissa Etheridge: Day 6

Vance Joy will perform on his Instagram Live for "Together, At Home: WHO-Global Citizen Solidarity Sessions." #TogetherAtHome

Christine and the Queens is doing something every day on Instagram and she promises "guests and weird concepts included."

Vanessa Carlton will host an Instagram Live performance every day at 5 p.m. CT starting Sunday, March 22 until Thursday, March 27 when she releases her sixth album Love Is An Art.

I So Lounging Day 5

Garth Brooks has announced he will play a concert on his weekly "Inside Studio G" Facebook series tonight. The show will be just Brooks and a guitar (and possibly wife Trisha Yearwood) taking requests for up to an hour.SiriusXM will also broadcast the show on The Garth Channel (ch. 55), Brooks' exclusive SiriusXM channel.

Lead singer from Death Cab for Cutie livestreams from his home. Previous editions have included Radiohead and Joy Division/New Order covers, plus plenty of Death Cab and Postal Service classics.

Butterboy, the weekly comedy show that normally happens Mondays at Brooklyn's Littlefield with hosts Aparna Nancherla, Jo Firestone and Maeve Higgins, will hold an online edition with guests Hari Kondabolu, Joyelle Nicole Johnson, Sean Patton, Adira Amram, Kyle Ayers, Caitlin Cook, Kendall Farrell and more. If you buy a $5 ticket you'll be sent a link to an unlisted YouTube so you can watch. Proceeds go "directly to the people making this show, both in front of the screen and behind the screen," with 10% being donated to Food Bank for New York City.

Doobie Decimal System Duo's Daily Live Stream from Marin, CA

Metropolitan Opera: Wagner's Tristan und Isolde (Opera)

The Met is hosting "Nightly Met Opera Streams" every day during its coronavirus closure. Each night is a different "complete operatic gem from our collection of HD presentations from the past 14 years." Each night's new opera begins streaming at 7:30 PM ET and will repeat through 3:30 PM the following day.

"Hey friends! We would love nothing more than to be out there on the road bringing the music to the people, but that's not possible right now. So we put our heads together and decided to start Stringduster TV, every week night at 6 PM MST."

Each Monday night you can tune in to watch a hand picked show from the archive. This week we rock with an unforgettable night from the Brooklyn Bowl on September 6th, 2011. While you watch, please consider making a donation to Conscious Alliance.

Metallica Mondays: Live at Slane Castle - June 8, 2019

Craig Wedren is performing improvised vocal soundbaths to accompany his Sabbath Sessions podcast at 8 p.m. ET Monday through Friday on Facebook.

Robin Barnes presents #SongbirdAtHome, a weekly event!

Give Monday Some Riespect

Old Salt Union is hosting a LIVE & ONLINE Webcast starting at 7PM Central Time Right here on Facebook Live. We're all in this together and can't wait to be able to get out there and see you in person. Until then please join the band for a set of tunes.

From Ridgewood, Brooklyn, NY

David Foster and Katharine McPhee from Malibu, California

Jazz Pianist

Live @ Home: Day 7

Phish tribute act Jazz Is PHSH will premiere their 'Live At Brooklyn Bowl' concert film to help raise money for the musicians of the collective impacted by the tour cancellations. The performance features Justin Stanton and Bob Lanzetti of Snarky Puppy, Felix Pastorius of The Hipster Assassins, Adam Chase of The Chase Brothers, John Culbreth of Naughty Professor and more.

Orville Peck, psychadelic cowboy, will perform tracks off his debut album Pony to celebrate its first anniversary, tease an upcoming record and chat with fans and special guests.

#DniceHomeSchoolpresents Quest Lovers Rock: Sloppy Seconds. For those of you that don't know him, Questlove is the legendary drummer for The Roots and drummer in the in-house band for The Tonight Show Starring Jimmy Fallon After turning in a killer DJ set Sunday night watched by more than 100,000 people, he's back at it today spinning killer R&B tunes and deep cuts. Tune in for another multi-hour DJ set! Let's hope he keeps this going every night.

Tune in to Reed Mathis' Daily Show Live From Home: Quarantine #7

Carlos Santistevan from Decentralized Sonic Quarantine Network

The Thomas Wesley Show

PHYSICAL DISTANCING MEETS LIVE MUSIC FOR A TRANSCONTINENTAL PUNK SHOW!

Kiana Lede performs for the twice daily Billboard Live At-Home series.

Third Man Records is hosting "Third Man Public Access," a series of live-streamed performance from their Blue Room in Nashville, TN.

Tune in everyday. at 1 p.m. ET for Sofi Tucker's daily live stream

Kontor Live is hosting "DJ Delivery Service," a daily series of live-streamed performance from Kontor Headquaters.

Tune in everyday. at 1 p.m. ET for Fred Hersch's daily live stream of jazz music.

No Take Away Shows during lockdown? No problem, here are the Stay Away Shows! We want our entire community and all music lovers to have access to their favorite artists and discover new talents during the confinement period. That's why we're launching the Stay Away Shows. Every day, at 7pm Paris time, 2pm NYC time, 11am LA time, on our instagram, friends from the Blogothque will come and play a live show with a lot of surprises. Please, stay home, stay safe, and see you tomorrow !

Miley Cyrus hosts a Monday-Friday hourlong live stream episode of her new series #BrightMinds.

Live from his pad in San Francisco, CA

X Ambassadors perform for the twice daily Billboard Live At-Home series.

Melissa Etheridge: Day 7

Christine and the Queens is doing something every day on Instagram and she promises "guests and weird concepts included."

Vanessa Carlton will host an Instagram Live performance every day at 5 p.m. CT starting Sunday, March 22 until Thursday, March 27 when she releases her sixth album Love Is An Art.

I So Lounging Day 7

Lead singer from Death Cab for Cutie livestreams from his home. Previous editions have included Radiohead and Joy Division/New Order covers, plus plenty of Death Cab and Postal Service classics.

Doobie Decimal System Duo's Daily Live Stream from Marin, CA

Metropolitan Opera

The Met is hosting "Nightly Met Opera Streams" every day during its coronavirus closure. Each night is a different "complete operatic gem from our collection of HD presentations from the past 14 years." Each night's new opera begins streaming at 7:30 PM ET and will repeat through 3:30 PM the following day.

"Hey friends! We would love nothing more than to be out there on the road bringing the music to the people, but that's not possible right now. So we put our heads together and decided to start Stringduster TV, every week night at 6 PM MST."

Craig Wedren is performing improvised vocal soundbaths to accompany his Sabbath Sessions podcast at 8 p.m. ET Monday through Friday on Facebook.

From Ridgewood, Brooklyn, NY

David Foster and Katharine McPhee from Malibu, California

Live @ Home: Day 8

Tune in to Reed Mathis' Daily Show Live From Home: Quarantine #8

RONATRONIX

Benny Benassi performs for the twice daily Billboard Live At-Home series.

Tune in everyday. at 1 p.m. ET for Sofi Tucker's daily live stream

Tune in everyday. at 1 p.m. ET for Fred Hersch's daily live stream of jazz music.

Third Man Records is hosting "Third Man Public Access," a series of live-streamed performance from their Blue Room in Nashville, TN.

Kontor Live is hosting "DJ Delivery Service," a daily series of live-streamed performance from Kontor Headquaters.

No Take Away Shows during lockdown? No problem, here are the Stay Away Shows! We want our entire community and all music lovers to have access to their favorite artists and discover new talents during the confinement period. That's why we're launching the Stay Away Shows. Every day, at 7pm Paris time, 2pm NYC time, 11am LA time, on our instagram, friends from the Blogothque will come and play a live show with a lot of surprises. Please, stay home, stay safe, and see you tomorrow !

Miley Cyrus hosts a Monday-Friday hourlong live stream episode of her new series #BrightMinds.

Lauren Jauregui performs for the twice daily Billboard Live At-Home series.

Live from his pad in San Francisco, CA

Melissa Etheridge: Day 8

Christine and the Queens is doing something every day on Instagram and she promises "guests and weird concepts included."

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Every concert you can livestream on March 23 during the coronavirus outbreak - CNET

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3 money moves one self-made millionaire is taking in response to the coronavirus pandemic – CNBC

Posted: at 5:50 am

In 2010, Grant Sabatier joined the FIRE (financial independence, retire early) movement, which embraces the concept of saving the majority of your income in your 20s or 30s so you can retire in your 30s or 40s.

In just five years, he saved over $1 million, enough to consider himself "financially independent," which gave him the freedom to start living a more entrepreneurial life. He founded the site Millennial Money, which helps others fast-track financial independence and reach early retirement, and he wrote the book,"Financial Freedom: A Proven Path to All the Money You Will Ever Need."

While Sabatier, who now lives in New York City with his wife, has a big cash cushion to fall back on, even the self-made millionaire is feeling the effects of the coronavirus pandemic, which has put major stress on the U.S. economy.

Here are three changes he's made with his money in response to the pandemic and its crushing economic impact.

Most financial advisors say to leave your investments alone in times of uncertainty and when the market is volatile.

Sabatier is following that advice for the most part: "I did sell some of my Amazon stock and diversified my portfolio a little bit." He wasn't planning on doing any rebalancing, "but I was a little overexposed in individual equities," he notes.

In general, though, he's keeping his hands off of his investments, staying the course and sticking to his long-term plan. Ignoring the urge to panic and pull out of the market is easier said than done, even for Sabatier: "I have to keep reminding myself that you only lose money when you sell, and so the losses themselves haven't been realized."

As a precaution, "I took out 10 grand in actual cash because I think there are certain times where ATMs could get frozen or a bank could stall," says Sabatier. "Having actual cash, and money across a couple of different banks, I think is a wise decision."

Other experts arequick to reassure consumers that if your money is parked in a bank insured by the Federal Deposit Insurance Corporation(FDIC), it's safe and there's no need to cash it out.

It doesn't hurt to have money across different accounts, though. Financial planner Scott Cole recommends having three to six months' worth of living expenses saved across two different accounts. Keep about $1,500 in the savings account tied to your primary bank and put the rest in a high-yield savings account, where it will likely earn you more in interest, he says.

If you need to dip into the $1,500 for an emergency, it will be readily accessible. Then, you can replenish the amount you used with savings from your high-yield account.

Sabatier used to check his net worth every day. It was a way to monitor his financial progress and stay motivated to reach his goals.

While he has a substantial cash cushion and isn't worried about his financial situation right now, "I'm human, so when your net worth drops 30% in a matter of 10 days, it sucks and that hurts and you feel it."

That's why he's putting the habit of looking at his account balances on hold: "I know things are going down." He's accepted that, for the time being, he's in "a preservation phase, and not a growth phase," but trusts that the markets will bounce back. When they do, he'll start checking his net worth again, but in the meantime, he doesn't need the stress and anxiety that comes with seeing your numbers drop.

Another way to stay focused on the long run may be to tune out some of the daily headlines. That's what investing legend Warren Buffett does. It helps him focus on where businesses will be five, 10 and 20 years from now, which is really what matters.

"I don't think I can make money by predicting what's going to go on next week or next month," Buffett told CNBC's Becky Quick. "I do think I can make money by predicting what will go on in the next 10 years."

Don't miss:Here's what you should do with your savings during the coronavirus outbreak

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Prince Harry and Meghan Markle Could Have a ‘Very Tricky Path’ to Financial Independence After Coronavirus Outbreak, Source Claims – Showbiz Cheat…

Posted: at 5:50 am

When Prince Harry and Meghan, Duchess of Sussex decided to stepback as senior members of the royal family, their main goal was achieving financialindependence from the crown while still supporting Her Majesty, QueenElizabeth.

But their split from the The Firm occurred long before thecoronavirusCOVID-19 absolutely demolished the worlds financial health in a matter ofweeks. While Meghan and Harry were probably feeling confident about makingmoney before, there is a significant lack of speaking engagements currently.

Suddenly, the prospect of making money isnt so simple forthis former royal couple.

The Duke and Duchess of Sussex essentially wantedto pick and choose which parts of the royal life they participated in. Theywanted to retain the good parts, like money, power, and prestige, while rejectingtheir least favorite aspects, like participating in the Royal Rota and remainingpolitically neutral.

It became quickly apparent that this approach was nevergoing to work Harry and Meghan were free to leave if they wanted, but theycouldnt just create royal roles as they wished. Queen Elizabeth sent thecouple words of encouragement but remained firm on her stance. They couldntuse the word royal in their branding, for instance. And yes, theyd have topay their own way.

That seemed easy enough when they first quit Harry evenlined up a high-profile speaking engagement at a JP Morgan Summit in February.But now events such as this have been canceled indefinitely, leaving Harry and Meghanstuck withoutan income stream.

Though it seems that way now, the coronavirus pandemic wontlast forever and life will eventually return to some kind of normal. However,financial ramification from business shutdowns that go on for weeks or monthscould wreak havoc on the economy. No one knows what will happen next.

A palace insider told U.K. based broadcaster Neil Sean thatPrince Harry is keenly aware how much the pandemic hasaffected his plans. The worldwide health crisis has plunged the worldinto a financial climate unheard of before and the opportunities for companiesto waste cash by booking celebrities to speak at conferences [arent thereanymore], said Sean. Now it could be a very tricky path to becomefinancially independent.

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These are uncertain times. And now, more than ever, we need each other. We need each other for truth, for support, and to feel less alone during a time that can honestly feel quite scary. There are so many around the world who need support right now, who are working tirelessly to respond to this crisis behind the scenes, on the frontline, or at home. Our willingness, as a people, to step up in the face of what we are all experiencing with COVID-19 is awe-inspiring. This moment is as true a testament there is to the human spirit. We often speak of compassion. All of our lives are in some way affected by this, uniting each of us globally. How we approach each other and our communities with empathy and kindness is indisputably important right now. Over the coming weeks, this will be our guiding principle. We will be sharing information and resources to help all of us navigate the uncertainty: from posting accurate information and facts from trusted experts, to learning about measures we can take to keep ourselves and our families healthy, to working with organisations that can support our mental and emotional well-being. In addition, we will focus on the inspiring stories of how so many of you around the world are connecting in ways big and small to lift all of us up. We are all in this together, and as a global community we can support each other through this process and build a digital neighbourhood that feels safe for every one of us. We look forward to sharing more over the days and weeks to come

A post shared by The Duke and Duchess of Sussex (@sussexroyal) on Mar 18, 2020 at 8:17am PDT

Unlike so many other people, Harry and Meghan are not in anydanger of losing their homes or not being able to put dinner on the table, eventhough theyre losing income in the coming weeks. Both have a healthy cushionof funds to fall back on if this pandemic drags on for several months. At the veryleast, they should be putting their multi-million dollar house hunt on hold.

The Duke and Duchess of Sussex have been using Instagram to spread messages of positivity and hope during the crisis. They encouraged fans to take care of their mental health in the days ahead. With everything going on, its a lot to take in. Many of us may feel confused. Or alone, or anxious or scaredand in isolation, some of us may just feel bored, or that you dont know what to do with yourself without your normal routine. Its perfectly normal to be feeling any of these things, they wrote.

But heres the good thing (because right now we need to hear good things, right?), they continued. Yes, there is isolation and physical distancing, but there doesnt have to be loneliness. They went on to share some resources to help fans survive social distancing.

These royals have no idea how coronavirus will affect their future. But theyre hoping to come out stronger than before.

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Self-made millionaire says the concept of retiring early ‘will disappear’ due to the coronavirus pandemic – CNBC

Posted: at 5:50 am

Americans are starting to feel the effects of the coronavirus pandemic, which has left few industries untouched. Some employees are already out of work and millions could end up losing their jobs in a potential recession.

The pandemic could even wipe out what's become known as the FIRE (financial independence, retire early) movement, which embraces the concept of saving the majority of your income in your 20s or 30s so you can retire in your 30s or 40s.

That's according toGrant Sabatier,Millennial Money founder and author of "Financial Freedom.""I think the whole idea of retiring early ... will disappear because of this," he tells CNBC Make It. "It's just not going to be as easy, even for people who have been saving up, and it's not going to be as attractive of an idea."

Sabatier started his own financial independence journey in 2010, before the movement really took off. He saved over $1 million in five years by launching a bunch of side hustles and setting aside upwards of 80% of his income.

Despite the movement's growth over the past decade, Sabatier says the concept of retiring early has already started to lose steam among younger generations. And the impact of the COVID-19 pandemic on the global economy and markets could be enough to eliminate the movement altogether, he says.

But that wouldn't necessarily be a bad thing, he says. "I think that idea of retiring early is, thankfully, disintegrating in the sense that, work is an important part of life. Work is healthy," he explains. "Doing something that you're passionate about is healthy. And money is often a byproduct of the things that we do to create value in the world."

Work is healthy. Doing something that you're passionate about is healthy. And money is often a by-product of the things that we do to create value in the world.

Grant Sabatier

Founder of Millennial Money

Sabatier, who became a millionaire before 30, didn't work a handful of side gigs and saveanextremepercentage of his income to stop working and settle down. For him, it's been less about retiring and more about "having freedom and options and choices," he says.

If you're intent on retiring early, use the extra time you may have right now to reflect on why, he suggests. "I often see people who want to retire early because it's something else to chase it's another trophy to get. When, in reality, so much of what they want they already have. Or, they're much closer to what they want than they realize.

"In this time when we're all quarantined and have a lot of time to think, think about why you really want to retire early. Do you still want that amidst the increasing uncertainty of our times?"

Sabatier encourages people still interested in the movement to focus less on the "retire early" part of FIRE and more on the "financial independence" aspect: "At its core, it's always been about using money to build a life you love and being intentional about your spending so that you have more time and options in your life."

Don't miss:Financial planner: Here's when you should temporarily stop saving for retirement during the pandemic

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The Best Strategies To Reach Financial Freedom – ETF Trends

Posted: at 5:50 am

By Jon Dulin

There are multiple roads to financial freedom but are you driving in the right direction?

The most important step to financial freedom is understanding what that freedom looks like to you.

It might seem like an unnecessary question but too many people follow the drumbeat for financial independence only to give up in frustration.

If you set out on a road trip with no destination in mind, youre going to run out of gas and get stranded!

Besides just defining that goal so you know in which direction to drive, a lot of people have a conception of financial freedom that may not be as good as they think.

For many people, the idea of Financial Independence, Retire Early (FIRE) is having enough money to quit their job and never work again.

OK, so you ditch the rat race and never work a day againthen what?

At best you become a sun-burnt alcoholic on some far-away beach.

Thats going to get old quick.

You need a purpose, something that gives your days and your life meaning.

For me, financial freedom was enough money that I could devote my time to developing my own business.

It was not worrying about money even when my online assets werent quite generating enough cash flow to pay all our bills.

Now that the business generates tens of thousands a month, financial freedom is doing what I love and never having to worry about money again.

Whether its being able to devote yourself to a charitable cause, running your own business, a hobby or whatever you choose, think about what financial freedom really means to you and about what youll do when you dont HAVE to work for the money.

Knowing where that destination is, you can find it on the map and start planning your course.

Ive found three roads to get you there.

Once youve figured out where you want to go, its time to get in the car and drive. And theres no way to FIRE thats more popular than investing.

Investing is also the easiest road to your financial independence. The boom ininvestment appshas made it easy to open an account and put your money to work.

Note that I said the easiest road, not the shortest.

Investing $6,000 a year and earning the long-term market return of 8% annually, it will take you 35 years to reach that seven-figure payday.

Even if financial freedom means a slightly smaller bank account, investing is like driving to your financial independence in a 92 Camry.

That doesnt mean you should give up on stocks and dump all your money in the other two ideas well talk about next.

Part of the beauty of the other ways to financial freedom is they dont cost a lot (or anything) to get started. That means you can still put your savings in stocks to watch that slow-ride to financial success.

If you decide to invest that hard-earned cash, remember these ideas:

I truly believe that real financial freedom is getting paid to do something you enjoy.

I love growing my online business, talking about financial success and goals, and making that personal connection through the YouTube channel.

Now that doesnt mean its all rainbows and unicorns.

I dont always jump out of bed in the morning and there are some parts of the business that still feel like a job.

But its a whole lot better than the feeling of being stuck in a job I didnt like, feeling like I had no control over my financial future and that my work didnt matter.

In fact, I enjoy running my online business so much, I dont really even think about retirement anymore. I cant imagine not doing this at least for a few hours every day.

And it all started as a side hustle.

Trying to find your side hustle idea? Try these steps:

From consulting or freelancing to writing books, you can make money on any idea.

Dont believe me?

There are 479 video courses on Udemy about solving a Rubiks Cube.

Thats 479 people that are making money from talking about that infuriating puzzle-box of the 80s.

If investing is like driving to your financial destination in an old beater, creating a side hustle is like a Corvette.

Youll still have to work on it and keep it running but it will get you there fast!

Our third strategy to financial freedom, and the favorite for most, is creating streams of passive income.

If you need to get to your financial destination as fast as possible, passive income is like putting the pedal down on a Maserati!

Passive income is money you make without having to do anything after setting it up.

That doesnt mean you never work again. It just means you have an income source producing cash flow while you devote your time to your side hustle or other tasks.

Be careful going after just any idea proposed as passive income though.

As much as I love blogging and creating videos for YouTube, these are pretty far from a passive income source.

The best passive sources are ones that take minimal upkeep or effort after launched.

A few of my favorite passive income ideas include:

Financial freedom isnt a destination you get to overnight.

If it were as easy as a leisurely Sunday drive, we all would have gone there years ago.

Figure out what that freedom really means to you, draw out your map and youll get there sooner than you think.

For many, simply knowing theyre on the right road to financial independence is all the motivation they need to keep driving.

Author Bio:Born and raised in Iowa, Joseph Hogue worked in corporate finance and real estate before starting a career in investment analysis. He has appeared on Bloomberg and CNBC and led a team of equity analysts for a venture capital research firm. He holds a masters degree in business and the Chartered Financial Analyst (CFA) designation. Joseph left the corporate world in 2014 to build his online businesses, first through creating websites and later through YouTube. Booking just $792.41 in 2015 income, hes grown his online assets to an income of $122,400 for the twelve-months to July 2019. Hes published 10 books and has grown the YouTube channel,Lets Talk Money, to over 161,000 subscribers in less than two years.

This article was republished with permission from MoneySmartGuides. View the original articlehere.

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Why the Supreme Court Should Protect the CFPB’s Independence – GovExec.com

Posted: at 5:50 am

Now the independence of the CFPB is under challenge in the Supreme Court. A law firm that we were investigating for possibly cheating its customers has mounted a challenge to block the investigation from proceeding. The Trump administration has sided with the law firm, contending that a government agency having a single director with some protection against removal by the president is a violation of our constitutional system of separation of powers.

Important cases about the structure of the federal government come along only from time to time. When they do, the politics of these cases can create strange bedfellows. So it was in this case, which produced several novelties: the Justice Department refusing to defend the lawfulness of an act of Congress, the agency charged with enforcing consumer-protection laws siding with a law firm accused of cheating its customers, and the House of Representatives but not the Senate being given time to present its views so the justices could canvass all the issues more fully.

As I sat in the courtroom and heard the abstract arguments the lawyers were making about the proper bounds between the legislative and executive branches of our government, my mind kept flashing back to more human moments from the unfolding of this constitutional drama. I thought about some of the tough enforcement actions we had taken, against companies such as Wells Fargo, for manipulating customer accounts to make employee bonuses and pump up the stock price. And our efforts over several years to draft new rules in order to safeguard the mortgage market against another meltdown that would jeopardize the financial future of millions of Americans. As that work was being called into question, I wondered about the practical consequences of this case for families that are cheated or mistreated every day in the financial marketplace.

But in the courtroom, those issues were only implicit. The case isnt about what the government can do for consumers; rather, it presents a classic confrontation between Congress and the president about how much authority each can exert over the removal of high-ranking federal officials charged with administering and enforcing the law. It poses difficult questions because whereas the Constitution clearly and plainly states that the president has the power toappointsuch officials (often with the advice and consent of the Senate), it is silent about who has the power toremovethem.

The issue has reared its head periodically in American history, often in tense situations. When President William Henry Harrison died just a month after taking office, his Cabinet sought to impose on his successor, John Tyler (known as His Accidency), a rule that he would be bound by their majority decisions about policy. He rejected that proposal, and before long, almost all those Cabinet members resigned. After the Civil War, congressional Republicans did not trust President Andrew Johnson to keep the Cabinet officials appointed by President Abraham Lincoln or to carry out the policy of Reconstruction as they believed he should. So they passed the Tenure of Office Act, limiting the removal of certain key officials without the approval of the Senate. When President Johnson defied the law and claimed it was unconstitutional, he was impeached, and escaped conviction by only one vote in the Senate. The legality of the Tenure of Office Act was never settled in the courts, but the statute was later repealed.

Other more obscure situations have given rise to celebrated Supreme Court decisions. One involved the fate of a postmaster in Oregonwhich led to a decision where Chief Justice William Howard Taft, himself a former President, proclaimed a doctrine of unilateral presidential control, unchecked by Congress, over the removal of executive officials for any reason, or no reason at all. Nine years later, another case involved a Federal Trade Commissioner who was fired by President Franklin Roosevelt and later passed away. His family sued for his back pay, contending that the firing was illegal because Congress had protected him from being removed unless dismissal was justified as being for cause (conduct more serious than mere policy disagreements). In that case, the Court reversed course and sided with Congress, holding that the president can be subject to modest restraints on his removal power where officials heading independent agencies exercise a broad mix of powers that seem in some ways to be executive, legislative,andjudicial in character.

Thus, it appears to be settled that the president is in fact the one who exercises removal power over executive officials, yet it is also settled that this removal power can be conditioned in limited respects by Congress, as is the case with independent-agency heads, such as the director of the CFPB. Subsequent cases, including one authored by Chief Justice Rehnquist in 1988, have largely followed this approach by holding that Congress, when it sees fit, can impose modest restraints on the presidents removal of executive officials.

These precedents are close to a century old, but they remain controversial. Some conservatives passionately embrace the theory of the unitary executive, which holds that the president must be able to exercise or control all executive power with no constraints. In practice, this means that if the president cannot do the entire job of administering and enforcing the lawa self-evident propositionthen at least he or she can control other executive officials by replacing them at any time. The natural human assumption is that the person who can fire me from my job can more readily ensure my allegiance to do the job as they see fit. And for those officials in the executive branch under the president, Congress should have no right to interfere in this control over their actions.

But this legal theory, while perhaps logical in the abstract, runs up against potentially embarrassing real-life problems. For example, the Constitution only contemplates two essential executive-branch officialsthe president and the vice presidentand every other executive official only has authority and duties and responsibilities as prescribed by acts of Congress. When it was determined that the country needed to create a new Department of Homeland Security, for example, the president was not free to make those wholesale changes in the organization of the executive branch on his own, but instead had to get Congress to pass legislation to authorize it.

In a different vein, the perceived evils of the spoils system in the 19th centurywhereby a new president could sweep out all executive-branch officials to make way for his own partisansled to congressional limits on the presidents ability to fire most executive-branch officials solely on political grounds. These protections are the accepted principle of civil-service reform that has endured to this day. They are not consistent with an all-powerful executive who can control every rank of executive officials according to his or her whims.

Accordingly, a more practical view of the separation of powers has been to reject the idea that each branch exercises its own powers in its own hermetically sealed sphere. On the contrary, the Framers set up a system of checks and balances whereby each branch interacts closely with the others, and each has various means of asserting itself against the others, so that no single branch of the government can establish tyrannical powers to infringe on the liberties of the people. For instance, the president has the power to interfere with Congress by vetoing legislation. Congress has the power to limit the president by controlling the budget and thus the size, scope, and aspirations of the executive branch. The courts have the authority to review actions taken by Congress or the president and to invalidate those deemed to be illegal.

In the sphere of appointment and removal, likewise, the Constitution gives scope to some interplay between Congress and the President. Since Congress alone can authorize the accretion of additional executive-branch officials and condition their powers, it makes sense that it can, to some extent, condition the grounds of their removal from office as well. And, again, it has done so with the civil-service reform laws that offer considerable protection for the tenure of large numbers of executive-branch officials who can only be fired for cause of some kind.

Of course, the case currently before the Court involves a high-ranking official with much broader powers than an everyday bureaucrat. And as the justices mulled the arguments, they were pulled in different directions as they considered the effects that their decision could have. In particular, they wrestled with two tough hypotheticals. Leaning too much toward Congress could lead to resuscitating the discredited Tenure of Office Act by upholding removal restrictions even on key Cabinet officers (potentially requiring the next president to keep Attorney General Bill Barr or Secretary of State Mike Pompeo in place even beyond President Trumps tenure). But leaning too far toward the president could lead to compromising the independence of such sacrosanct officials as the chair of the Federal Reserve, conferring the power to set interest rates and manipulate the economy for purely political purposes, not necessarily in the public interest. The justices seemed to almost visibly shy away from either of these extremes.

In the end, though the argument offered a muddle of different approaches, the Court is likely to issue a ruling that is fairly limited as a practical matter. A bare majority of the Court may hold that the president can remove a single director of an agency at will and cannot be limited by the for cause removal provision imposed by Congress. But there were other indications that the Courts decision would embrace the big picture by allowing the CFPB to continue to operate and to protect consumers, as Congress intended. As Justice Ruth Bader Ginsburg reminded everyone at the argument, while both Congress and the president had their lawyers arguing before the bench, it is important to remember that consumersthat is, all of ushave weighty issues at stake in this case too.

This story is part of the project The Battle for the Constitution, in partnership with the National Constitution Center.

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