Daily Archives: March 24, 2020

Legislature fails to support DNA testing that would have helped inmates like Tommy Zeigler – Tampa Bay Times

Posted: March 24, 2020 at 6:00 am

A bill in the Florida Legislature that would have eased the requirements for inmates seeking DNA testing failed this past week, shutting out Tommy Zeigler and inmates like him from testing their evidence with modern forensic methods.

Zeigler has been on death row for 44 years for the murders of his wife, in-laws and another man at his familys furniture store in Winter Garden on Christmas Eve 1975. He was shot in the stomach that day and has always maintained he and his family were victims of a robbery attempt.

The bill, sponsored by Tampa Rep. Jamie Grant, the Republican chairman of the House Criminal Justice Subcommittee, would have likely allowed Zeigler to test the corduroy shirt and plaid pants he wore on the day of the crime for the victims blood. It would have enabled him, for the first time, to test their fingernail clippings.

Grant, who researched how other states handle DNA testing, ushered the bill through his subcommittee, the Appropriations Committee and the Judiciary Committee -- unanimously. Even the full House approved it, 114 to 0, last week.

But the bill died when the Senate failed to pick it up. Later, it was added to another criminal justice reform bill, which also failed as the House and Senate haggled over the details.

Ill keep working on it until its done, Grant said Monday. I think this is an example that sometimes the process can be really ugly.

Grants bill would have changed Florida statute, which now says inmates must be exonerated by forensic testing, such as a DNA test that might identify the true rapist. The bill would have allowed for forensic testing even if it would just provide evidence in a case or point to an accomplice.

David Michaeli, one of Zeiglers New York attorneys, said he was encouraged by the fact that House Bill 7077 passed one chamber of Floridas Legislature unanimously.

How many bills accomplish that? he said. It tells us something about the common sense wisdom of testing and the fact that it is a nonpartisan issue.

He said they would not give up fighting for the testing.

Inmates who have been in prison the longest struggle the most for permission to conduct DNA testing, even those who offer to pay for it. Zeiglers requests have been rejected six times.

I think the Florida experience is similar to the experience in other states, said Robert Dunham, executive director of the Death Penalty Information Center in Washington D.C. What were seeing in state after state is that the standard for obtaining (DNA testing) is so high, and the rules are so stringent, that folks are being executed without the testing being done.

In Georgia, he said, a man was executed last November for shooting a convenience store clerk in 1994 -- without obtaining forensic analysis. In January, the City Council in Jacksonville, Ark. agreed to turn over evidence in a 1993 murder to the family of a man executed in 2017. Courts also had turned down his request for DNA testing.

The Tampa Bay Times reviewed the cases of 46 men on Floridas death row who asked for permission to conduct DNA testing and found that judges turned down 38 of them at least once. Nineteen were denied all DNA testing, including eight who were later executed.

That analysis was featured in a multipart series and podcast called Blood and Truth.

Were running out of time with Tommy, theres no doubt about it, said Terry Hadley, one of his original attorneys.

Zeiglers lawyers say the forensic tests could prove the 74-year-old innocent and point to another perpetrator. They say that even the states DNA expert said the killers clothes should have blood evidence from the victims, particularly those slain in a gruesome fashion or at close range. If Zeigler has none of the victims blood on his clothes, the lawyers argued in a memo to the state, then he did not kill them.

But last year, State Attorney Aramis Ayala turned down Zeiglers latest bid even though her conviction integrity unit recommended the testing. She opposed it, she said, because the DNA testing would not outright exonerate Zeigler.

Contact Leonora LaPeter Anton at llapeter@tampabay.com Follow @WriterLeonora.

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Design Therapeutics debuts with $45M to tackle degenerative disorders – FierceBiotech

Posted: at 6:00 am

There is no treatment for inherited degenerative disorders like Friedreich's ataxia, so care focuses on relieving symptoms. With $45 million and technology out of the University of Wisconsin, Design Therapeutics is trying to change that.

The company uncloaked Friday with $45 million in series A funding to push a treatment for Friedreich's ataxia into the clinic. It will also advance its discovery-stage programs in other degenerative disorders such as Fragile X syndrome and myotonic dystrophy.

San Diego-based Design Therapeutics is taking aim at nucleotide repeat disorders, where a mutation increases the number of times a DNA sequence is repeated. These mutations cause disease in multiple waysthe affected gene may produce an abnormal protein, or it may not produce enough of a required protein, as is the case with Friedreich's ataxia.

RELATED: Triplet Therapeutics launches with $59M, Nessan Bermingham at the wheel

Most patients with Friedreich's ataxia have an expanded GAA repeat in their FXN gene that blocks transcription, resulting in limited production of the frataxin protein. Designs lead program aims to unblock transcription. The series A funding, from SR One, Cormorant Asset Management, Quan Capital and West River Group, will bankroll IND-enabling studies for the program.

Significant industry advancements have led to the understanding of root causes of multiple nucleotide repeat disorders, however, there remain few to no therapeutic options that slow the progression or reverse the course of disease, said Pratik Shah, Ph.D., Design co-founder and executive chairman, in a statement. Our company was founded with a goal of designing a new class of small molecule therapies that address the core etiology of diseases to deliver a biological effect typically only seen with complex molecules.

Triplet Therapeutics, which launched in December, is taking a different tack. Its looking at a specific subset of repeat expansion disorders called triplet repeat disorders, so called because they result from repeats of three nucleotide bases, or letters. Rather than developing drugs on a disease-by-disease basis, it is doing so on a tissue-by-tissue basis, so it could potentially treat multiple diseases with the same drug.

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DNA riddle: how cells access data from ‘genetic cotton reels’ – News – The University of Sydney

Posted: at 6:00 am

Professor Joel Mackay.

Professor Mackay said: This protein effectively remodels our DNA to allow access to the information that determines the fate of a cell and its ability to respond to signals from the outside. It is a critical protein for almost all the work that cells do, including cell division and DNA repair.

Understanding this process will be critical in the long term for developing treatments for neurodevelopmental disorders and some cancers.

These illnesses are in part triggered by defects in the remodelling of the DNA that is driven by this process, Professor Mackay said.

The protein CHD4 and its close partners are emerging as important risk factors inpolygenic neurodevelopmental disorders, schizophrenia and bipolar disorder, as well as inrare monogenic disorders, such as GAND, which causes severe mental disability, Professor Mackay said.

He said that mutations in the CHD4 protein that impair its function are also associated with endometrial carcinoma.

The research was in collaboration with scientists at the University of Wollongong and the Australian National University.

The work was funded by the following grants from the National Health and Medical Research Council of Australia: APP1012161, APP1063301, APP1126357 and a fellowship from the same organisation to Professor Joel Mackay (APP1058916). Antoine van Oijen is an Australian Research Council Laureate Fellow.

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Claremont serial killings trial podcast: Unlike DNA, Fibres CAN Fly Around the Room – PerthNow

Posted: at 6:00 am

After a 10-day break, WAs trial of the century resumed - with strict and widespread cleaning and social distancing measures to ensure this mammoth trial can continue.

Compared to previously in the trial - when the public gallery was packed to the point a separate room was set aside for overflow - one person from the public was in court.

And what they heard was the beginning of the fibre evidence, which focussed on Jane Rimmers hair mass.

For full coverage of WA's trial of the century, head to TheWest.com.au

Fibres are critical to the prosecution to link Ciara Glennons fingernails - which they say contained Bradley Edwards DNA - to Jane Rimmer and the Karrakatta rape victim.

Without any DNA evidence linking Jane to the accused, or any DNA evidence at all, the prosecution say 22 critical fibres were found in Janes hair, which came from specially made Telstra pants that Bradley Edwards would have worn in the mid 90s.

They say those fibres got there through Bradley Edwards taking Jane in his car, and getting close enough to her when he was killing her.

The defence, however say contamination is also the way those fibres got into Janes hair mass.

If youre just joining the trial now, you can start from season 2, episode 1, or our special two-part catch up, called JUMP IN NOW: Claremont the Trial Catch Up Part 1 and 2.

If you have any questions about the trial for any of the guests, send them in to claremontpodcast@wanews.com.au

Join Natalie Bonjolo, Tim Clarke and Forensic expert Brendan Chapman as they discuss day 60.

For more information on WA's trial of the century, head to TheWest.com.au

Subscribe now: Apple Podcasts | RSS | Spotify

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Indian scientists building DNA database to protect the elusive red panda – Mongabay-India

Posted: at 6:00 am

Indian scientists are building a DNA database for red panda populations in the country, even as a report warns of serious threats to the bushy-tailed and chestnut-furred animals. The main threats are from habitat degradation, amid low levels of crime related to the species in India.

According to Zoological Survey of India scientist Mukesh Thakur, the reference DNA database for existing populations of red pandas will aid conservation efforts and come in handy to combat illegal wildlife trade by helping law enforcement officials assign the seizure (of illegal wildlife trade derivatives) to the source of origin, which would aid prosecution.

Thakur has also acknowledged and accepted the recent genetic evidence that red pandas are actually two separate species Chinese (Ailurus styani) and Himalayan red panda (Ailurus fulgens).

The two species are distributed in the eastern and north-eastern Himalayan subalpine conifer forests and the eastern Himalayan broadleaf forests, which geographically fall in China, India, Nepal, Bhutan, and northern Myanmar.

The International Union for Conservation of Nature categorises red panda as endangered because its population has plausibly declined by 50 percent over the last three generations (estimated at 18 years) and this decline is projected to continue, and probably intensify, in the next three generations.

Experts estimate that around 14,50015,000 individual red pandas remain worldwide. The main reasons for the population decline are habitat loss and degradation in almost all the range countries.

In India, the animal is distributed in three states only: West Bengal (Darjeeling district only), Sikkim and Arunachal Pradesh, Thakur said, noting there is no recent report of red panda presence from the Meghalaya Plateau. The animal is protected under Schedule 1 of the Wildlife Protection Act 1972 in India, which means it is accorded the same protection as tigers.

Adding to conservation efforts, Thakur is leading the study of fine-scale landscape genetics of red panda covering the eastern Himalayas and building a reference DNA database to help in the identification of confiscated cases, under an ongoing five-year project of the government of Indias Department of Science and Technology INSPIRE Faculty scheme.

We are collecting poop of red pandas from all across the distribution in the eastern Himalayas to build a DNA database and we have already done it from the wild populations in Kangchenjunga landscape, covering North Bengal and Sikkim. We collected 250 plus faecal samples and genetically identified 24 unique individuals in the landscape in India, Thakur of Centre for DNA Taxonomy and coordinator Centre for Forensic Sciences, Zoological Survey of India, told Mongabay-India.

Now in the second phase, we are focussing on red panda populations in Arunachal Pradesh. So far about 50 faecal samples have been collected from various parts of Arunachal Pradesh and my students, Hiren and Supriyo are still in the field for sample collection and conducting surveys. I hope by next year we will have the complete picture of red panda populations in India, he said.

The 25,085 square km Kangchenjunga landscape (KL), encompassing India, Nepal and Bhutan, ranges in elevation from 40 metres to 8,586 metres and is home to more than seven million people, while hosting more than 4,500 species of plants and at least 169 mammal and 618 bird species.

The landscape supports the transboundary population of red pandas in India, Nepal, and Bhutan. To learn more about how populations are faring in the India part of the landscape, the scientists undertook distribution modelling and fine-scale landscape genetics. They discovered that due to habitat fragmentation and rapid changes in the land use patterns, the red panda populations exist in a series of localised, small, imperfectly connected populations.

Our investigations suggest that about 1309.54 square km area is suitable for red pandas in the Indian part of the Kangchenjunga landscape, of which 62.21 percent area falls under the protected area network, Thakur said, adding that there is no India-level exact estimate of the red panda populations.

The National Studbook on the red panda (April 2018) states that the current captive population of red pandas in India includes 24 individuals in three zoos. The population retains a limited amount of genetic diversity and includes closely related individuals.

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Microsoft account | Sign In or Create Your Account Today …

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One account. One place to manage it all. Welcome to your account dashboard.

Get started with Microsoft products and more.

Change a password, update security information, and keep vital account details up-to-date.

Review your search history, browsing and location activity, and more.

Keep your family safer online and stay connected even when youre apart.

Update your payment information, check your order history, redeem gift cards, and get billing help.

Quickly renew and manage your favorite Microsoft subscriptions and services in one place.

Find, lock, or erase a lost or stolen Windows 10 device, schedule a repair, and get support.

Get expert answers and advice on Microsoft products and services.

Access your favorite Microsoft products and services with just one login. From Office and Windows to Xbox and Skype, one username and password connects you to the files, photos, people, and content you care about most.

Email and calendar together. All you need to be your most productive and connected selfat home, on the go, and everywhere in between.

Skypes text, voice and video make it simple to get closer to the people who matter most across all of your devices.

The faster way to get things done on the web with built-in features for staying organized, researching, and discovering.

Intelligent search features make it quick and easy to find what you need answers, news, entertainment, and more.

Play your favorite games in more places than ever. Easily access your games, friends, and community across Xbox One, Windows 10 PC, and mobile.

Achieve what matters to you with Word, Excel, PowerPoint, and more. What will you do with your next 365?

Safely store and access your files and photos on all your devices. Your Microsoft account comes with 5GB of storage and the option to add more when you need it.

Find, lock, or erase a lost or stolen Windows 10 device, schedule a repair, and get support.

Mixer is where gamers come together to play, celebrate, and share the best moments in gaming.

Experience all thats possible with Microsoft, from the best in productivity and creativity to gaming and entertainment.

Save time and stay organizedCortana helps handle day-to-day tasks so you can stay on top of what matters most.

With MSN, the information that enriches your life is accessible every moment of every day.

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Microsoft gets ready for a new era of Windows – The Verge

Posted: at 5:59 am

Microsoft reorganized its Windows + Devices team last month, placing Surface chief Panos Panay in charge of both Windows and hardware. While its still early days for Panay, were starting to get an idea of how things might change with Windows. That starts with a new Windows Insider leader, Microsofts beta program that sees millions of people testing Windows 10.

In my first 30 days as the Windows leader, as Ive been spending time listening, learning, and working with the team to build a vision for the next era of Windows, Ive been in awe of the Insiders group and the level of dedication and depth of knowledge they have, explains Panay in a new blog post today. To keep this momentum going and continue to grow and innovate in Windows, its clear we need the right person to lead this powerful community into the next era, which is why Im excited to announce Amanda Langowski as the new lead for the Windows Insider Program.

Langowski is a Microsoft and Windows veteran, having worked at the company for more than 20 years. Langowski previously worked on Windows beta programs, Windows Mobile, Windows Phone, and the all-important flighting team that makes sure builds of Windows are available for engineers inside and outside of Microsoft.

Langowski will now take over as the face of Windows 10 testing and lead an important feedback loop, a role that Dona Sarkar previously led for the past few years. Sarkar has taken a new role in the Microsoft Developer Relations team and remains at the company, while the previous Insider chief, Gabe Aul, left Microsoft last year for a virtual and augmented reality engineering role at Facebook.

As Panay says, Microsoft is now getting ready to build a vision for where Windows goes next. The software maker has tried a variety of ways to entice creators to Windows over the past five years, but it has walked back some of those changes. The pace of Windows 10 updates has certainly slowed over the past 12 months, leaving testers and Windows fans wondering whats coming next.

Microsoft is obviously focused on Windows 10X for dual-screen devices right now, but there will be plenty of changes coming to the desktop version, too. Panay hasnt finalized his vision for the direction of Windows, but you can expect to see a renewed focus on the OS at Microsoft. That will no doubt include some of the pumped energy Panay is famous for, but also a focus on simplifying the operating system and cleaning up some areas that havent been looked at for quite some time.

Microsoft CEO Satya Nadellas bold goal was we want to move from people needing Windows to choosing Windows, to loving Windows, five years ago. Its fair to say Windows 10 has certainly improved over the past five years, but a fresh vision for where it needs to go and a face for Windows is very much needed.

I expect, and certainly hope, to see a bigger focus on Microsoft adapting the OS to the people who truly use it every day and rely on Windows. Thats not to say there wont be some big new features that the company will develop, but PowerToys for Windows 10 and the Windows Terminal have been some great additions.

Were starting to see some of the simplifications for Windows show up, with new icons and even some tweaks to the Start menu. Panay celebrated a billion Windows 10 users with a teaser video last week, and its clear the Windows team is looking at cleaning up parts of the UI. Microsoft is ready to listen again, with new leadership involved at the top of Windows and how the company receives feedback. Were now waiting to hear exactly what the next era of Windows will bring. Some of those answers might not be too far away.

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HP is teasing a new VR headset in partnership with Valve and Microsoft – The Verge

Posted: at 5:59 am

HP is teasing a followup to its Reverb virtual reality headset made in collaboration with Microsoft and Valve. The announcement coincides with Valves release of Half-Life: Alyx, the years most anticipated VR game. Theres little detail, but HPs website calls its new headset a more immersive, comfortable, and compatible experience than the Reverb, and an email from the company calls it a no-compromise VR headset.

The $599 Reverb was part of Microsofts Windows Mixed Reality lineup, known for its high-resolution screen. HPs reference to a new standard in VR suggests its not competing with the cheapest VR devices, like the $399 Oculus Rift S. But it might not cost as much as Valves $999 Index, either. Theres no release date, though, so we dont know if it will mitigate the current headset shortage or if it might be delayed because of the coronavirus pandemic, which has slowed production of existing Valve and Oculus products.

Valves SteamVR platform already supports Windows Mixed Reality headsets alongside other products from Oculus and HTC. And the headset looks similar to the old Reverb, with two black spots that imply the use of Windows Mixed Reality tracking cameras, rather than SteamVR-style external tracking beacons. So were not sure what this specific Microsoft / Valve / HP collaboration entails.

I will note, however, that Windows Mixed Reality has a convenient tracking system and mediocre controllers, while the Valve Index has an inconvenient tracking system and the best controllers in VR. Valves current controllers cant work with HPs tracking system. But their most distinctive features use internal sensors, not SteamVR beacons and expanding those beyond the Index would be good for everyone involved.

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Amazon and Microsoft join White House team to unleash high-performance computing on COVID-19 – Yahoo Tech

Posted: at 5:59 am

Less than a week after the White Houses Office of Science and Technology organized a consortium to focus the power of artificial intelligence on addressing the coronavirus outbreak, another tech team is joining the fight this time, armed with supercomputers and the cloud.

The COVID-19 High-Performance Computing Consortium includes the Seattle areas powerhouses of cloud computing, Amazon Web Services and Microsoft, as well as IBM and Google Cloud.

There are also academic partners (MIT and Rensselaer Polytechnic Institute), federal agency partners (NASA and the National Science Foundation) and five Department of Energy labs (Argonne, Lawrence Livermore, Los Alamos, Oak Ridge and Sandia).

Among the resources being brought to bear is the worlds most powerful supercomputer, the Oak Ridge Summit, which packs a 200-petaflop punch.

America is coming together to fight COVID-19, and that means unleashing the full capacity of our world-class supercomputers to rapidly advance scientific research for treatments and a vaccine, Michael Kratsios, the White Houses chief technology officer, said in a news release.

The research projects supported by the consortium are expected to range from studies of the SARS-CoV-2 virus molecular makeup, to the bioinformatics behind the workings of the virus, to the epidemiology behind COVID-19s spread and the strategies for stopping it. The common thread is the need for high-performance computing resources to get a handle on the complex challenges of such studies.

Microsoft will be providing grants to researchers through its AI for Health program, to ensure additional access to Azure Cloud and the companys high-performance computing capabilities. AI for Healths data science experts will also make themselves available to collaborate on COVID-19 research projects.

We want to make sure researchers working to combat COVID-19 have access to the tools they need, said John Kahan, Microsoft Global AI for Health lead.

Amazon Web Services is offering research institutions and companies technical support and promotional credits for the use of AWS services to advance research on diagnosis, treatment and vaccine studies relating to the coronavirus and its effects.

Were proud to support this critical work and stand ready with the compute power of AWS to help accelerate research and development efforts, Teresa Carlson, vice president for AWS Worldwide Public Sector, said in a statement.

Similar access to high-performance computing resources is being made available to researchers via Google Cloud HPC, the IBM Research WSC Cluster, NASAs High-End Computing Capability, Rensselaers AIMOS supercomputer system, the MIT/Massachusetts Green HPC Center, NSFs Office of Advanced Cyberinfrastructure (which can provide access to Frontera, the fastest supercomputer deployed on a U.S. academic campus) and the five national labs.

To take advantage of those resources, researchers should submit a simple project proposal via consortiums website. A steering committee will review proposals for potential impact, feasibility, resource requirements and timeline.

Each proposal thats selected will be matched up with computing resources from one of the consortiums members. That member will then get in contact with the research team to discuss the process for obtaining access to the resources.

Researchers making their proposals should expect to produce a regularly updated blog of their activities during the course of their work, and have publishable results come out of their efforts.

Microsoft is also part of the team behind the COVID-19 Open Research Dataset, or CORD-19, which is offering an AI-enabled database to provide faster, surer, wider-ranging access to coronavirus research.

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Noise-canceling headphones from Microsoft, Beats and Anker are cheaper today – The Verge

Posted: at 5:59 am

If youre having trouble concentrating on your work during self-quarantine, a set of quality noise-canceling headphones might be a good solution. Youll likely get a lot of use out of them in the coming weeks (possibly months) at home. Best Buy is offering a $150 discount on Microsofts Surface Headphones, which are over-ear, noise-canceling wireless headphones. These usually cost $350, but now theyre $200.

This model stacks up well compared to Sonys popular WH-1000XM3, even going beyond them with their ability to simultaneously pair to two Bluetooth devices. More expensive headphones have this feature, like the $400 Bose Noise Cancelling Headphones 700, but its nice to have it with this discounted set.

Best Buy is also offering a nice discount on the Beats Studio 3 noise-canceling headphones, which usually cost $349. The sale price is $200, and if youre picking between these and the Surface Headphones above, these are easier to pair with Apple products, like the Apple Watch, iPad, iPhone, and MacBook Pro, thanks to their W1 wireless chip.

Its understandable if $200 to spend on headphones isnt in the budget right now. Ankers Soundcore Life 2 over-ear, noise-canceling wireless headphones are just $40 at Newegg (via Skimlinks). These offer 30-hour battery life, optional wired mode with the included 3.5mm headphone cable, and they can easily fold up in their included hard case. Use the offer code ANKR25 to save.

Borderlands 3 is down to just $20 for the Xbox One and PS4 at Amazon. This game regularly costs $60, and at this price, youll get the physical version. If youd rather have the digital code for Xbox One, it costs $30. This game could suit you well if you want an open-world FPS that lets you team up with friends to face off against waves of enemies and collect loot.

If you recently got a Nintendo Switch to play Animal Crossing: New Horizons and now find yourself amassing more games than the consoles 32GB of onboard storage can handle, pick up a micro SD card. SanDisks 400GB model is down to $52.99, which is less than the cost of a new game. With a storage card this big, you probably wont have to think about upgrading it ever again at least, not for a while. This isnt a huge deal, but it always pays to have storage when you need it. And around this time last year, these cost about $30 more.

The Kindle Paperwhite is back on sale for $95 (usually $130). Amazon had this sale just a few weeks ago, but its here again in case you missed out the last time. This isnt the most affordable e-reader you can buy, but its one of the best, thanks to its waterproofing and great backlit display.

T-Mobile is gifting its customers with two months of complimentary YouTube Premium service as a thanks for staying inside during the novel coronavirus pandemic. This service eliminates advertisements, enables background play, and allows you to download videos to your phone. T-Mobile customers using Android can access the offer starting tomorrow in the T-Mobile Tuesdays app, and iOS users can find it on t-mobiletuesdays.com. The fine print states that you have to redeem this offer by May 1st, and if you forget to unsubscribe, youll be charged once your two months of service are up.

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