Daily Archives: March 23, 2020

Oxford academic claims future humans could live for thousands of years – Express.co.uk

Posted: March 23, 2020 at 11:45 am

The comment was made by Anders Sandberg, a senior research fellow at the universitys Future of Humanity Institute. His work focuses on the potential risks future technology could pose to human civilisation.

Mr Sandberg has also spent decades involved with the transhumanist movement, which consists of people who believe humans can and should use technology to artificially augment their capabilities.

Speaking to Express.co.uk he argued humans in the future could enjoy greatly expanded lifespans and could even have their brains uploaded onto computers for safekeeping.

Asked how long humans could live Mr Sandberg replied: There is no fundamental ceiling but you are going to need to solve certain problems.

Accidents is the first one cryonics wont help you if a bus runs over you and turns you into mush.

Even if ageing and disease is not a problem you need to handle accidents and probably that means having some form of backup copies. You need some form of uploading or artificial body.

Probably the human brain cant handle that much information so you need to extend it as you get older.

You want to remember what needs to be remembered and maybe put other stuff in cyber storage.

Transhumanists believe humans can halt the ageing process and natural death.

According to Mr Sandberg this is one of the most provocative aspects of their programme.

He explained: Transhumanists have essentially since day one been saying we should really extend the human lifespan and this is perhaps one of the most controversial claims ever made.

We get way more pushback when talking about life extension than cloning or uploading into computers or going to space or taking drugs to become a more moral person.

Thats nothing compared to the potential of oh you might live much longer than you expected.

READ MORE:Academic explains how humans could become part mechanic cyborgs'

That is kind of dreadful to many people so they get very upset and start defending disease, sickness and death very strongly.

Its weird because if one believed their arguments we should be shutting down hospitals left and right and having people naturally and painfully die which of course people dont normally do. Normally we are very keen on having good hospitals and ambulances.

Mr Sandberg is the co-founder of Swedish thinktank Eudoxa and previously chaired the Swedish Transhumanist Association.

Transhumanist ideas have been gaining ground over recent years, with transhumanist political parties emerging in countries across the world including the UK.

An American transhumanist, Zoltan Istvan, recently ran against Trump for the 2020 Republican Presidential nomination.

Mr Sandberg also suggested advances in AI and drugs that improve human abilities are likely to play a role in the future.

READ MORE:US Presidential hopeful plans to ABOLISH DEATH using technology

He asserted: Its very likely artificial intelligence is going to become extremely powerful relatively soon.

Not necessarily the kind of self-willed Hal like being but at least very smart services that can solve problems for us which might speed things up.

I also have been working quite a lot on the ethics of cognitive enhancement. What about making ourselves smarter?

The good news is there are various things like smart drugs that might be helpful for certain mental tasks.

The bad news is there doesnt seem to be anything that really boost intelligence itself. That seems to be very complicated and we dont understand the brain well enough.

Oxford Universitys Future of Humanity Institute was founded in 2005 to focus on the opportunities and threats that could emerge for the human species.

It is headed by Swedish philosopher Nick Bostrom, who grabbed wide attention with his 2014 book Superintelligence: Paths, Dangers, Strategies.

Asked what the world could look like in 40 years time Mr Sandberg replied: think a time traveller going 40 years into the future is first going to be super disappointed because it looks almost the same.

On the surface I think its going to be very similar theres going to be vehicles moving around, maybe without any drivers, there are going to be houses around and so on and then they start interacting with people and theyre going to realise this society works completely differently.

We most likely are going to have quite a lot of enhancements around that are regarded as everyday.

People are not going to think that the morning cognition enhancing pill is any weirder than the morning coffee they might even be the same thing.

The existence of a lot of machine learning and probably nanotechnology making a lot of material way more alive than they used to.

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How Long Do You Want to Live? This Technology Could Potentially Help People Live Forever – Interesting Engineering

Posted: at 11:45 am

The coronavirus may have you thinking about your mortality. At the end of the day, humans only have one life on this planet. Even more so, we are pretty fragile, prone to disease, destructive, and a bit stubborn. Since the beginning of time, humans have longed for eternal life," - the ability to extend ones life and youth far beyond its current limits. Nevertheless, you have to give humans their props for increasing their species life expectancy across the board over the last 200 years.

For the uninitiated, life expectancy is the expected number of years of life remaining at a particular age. Yet, as you are probably already wondering, how long can humans live? According to Our World in Data, the average life expectancy is 72.6 years. Yet as you are probably aware, there are select groups of people across the world, especially in wealthier nations, that have well exceeded this number. Some people have gone on to live 100 years, 110 years, and even beyond, with Jeane Calment of France living 122 years and 164 days.

But can humans live even longer? If you could, how long would you want to live? 200 years? 500 years? Maybe a full millennium? Though this might seem like a bit of science fiction, technology could advance to the point where humans could live forever. In fact, some futurists argue that if you make it to 2050, you are probably not going to die. So, stay inside, please.

Futurist Dr. Ian Pearson has gone on to argue that by using the power of technology, humanity might be able to merge our minds with machines, making our bodies obsolete. You could end up attending your own body funeral. Pearson paints the picture of this future,stating, One day, your body dies, and with it, your brain stops, but no big problem, because 99% of your mind is still fine, running happily on IT, in the cloud. Assuming you saved enough and prepared well, you connect to an android to use as your body from now on, attend your funeral, and then carry on as before, still you, just with a younger, highly upgraded body.

And this is just the beginning, beyond 2050, there could be many different ways you may be able to preserve your mind and consciousness. Humans might just switch to different humanoid bodies after a certain period the same way you might buy a new car with new features. Or thanks to projects like Neuralink, your mind may just be a few simple clicks away from downloading yourself into a computer or robotic body. Maybe thousands of years from now, all of humanity may decide it is better for humans to live in a massive megastructure that practically generates our own reality.

Today that is what we are going to explore. There is plenty of technology out there that could potentially change the entire direction of humanity, posing the question; will humans eventually be able to live forever?

Like most of the things on this list, this sounds like something out of a science fiction film. Yet people like University of Southern Californias Theodore Berger, Duke Universitys Mikhail Lebedev, and Alexander Kaplan of Moscow University, all believe its possible. There are already companies out there working on ways to link our minds to machines. At the moment, there are more practical reasons for this. like offering those who have mobility disabilities the ability to live more normal and fulfilling lives.

However, it can go even further than that. The mind will be in the cloud, and be able to use any android that you feel like to inhabit the real world,says Pearson. It could get to a point in which you can hire an android body for the day. Rather than travel to Jamaica, just upload your brain to an android stationed in Jamaica. Or maybe there is a great concert that you want to see, but the band is in another city thousands of miles away. You may be able to simply upload yourself to experience the show. The result of this is that humans may never need a fleshy body again.

3D printing has come a long way, virtually impacting almost every major industry across the world, including healthcare. Just in the past couple of years, researchers from separate organizations and private institutions have found ways to 3D print organs. A team of researchers from Tel Aviv University in Israel unveiled a 3D printed heart with human tissue and vessels just last year.

Companies like Skorpio Medical have gone as far as to begin research in the realms of 3D printed limbs. In the near future, you may be able to simply renew a body part when it goes bad. Your body gets more and more limited as you get older. Advances in biotechnologies could put an end to this. Even more so, genetic engineering could eventually prevent the aging of cells or completely reverse it altogether. Lose a finger? Simply print a new one? Need a new arm? Call up a doctor and have them reinstall one.

Cryogenic freezing has its fair share of skeptics, but over the years, the scientific community has slowly embraced the idea. Now, you cannot freeze yourself yet and wake up, but there could be a future in which you simply put your body on ice for extended periods of time to be awakened on a given date or time.

This could come in handy during trips to distant planets hundreds of light-years away. Nevertheless, cryogenic freezing is simply an option for people who want to freeze their bodies when they pass away with the aims of bringing them back during a time period where science makes it possible. However, there is some research that centers around using cryonics to slow tissue aging.

You have probably heard it before, but we are probably living in a virtual world, at least that is one people who buy into simulation theory believe. However, in the coming age of electronic immortality, living in the virtual world may become an alternative to living in the current one. Think of it like that episode of San Junipero from the popular Netflix series Black Mirror. Perhaps in the future, androids are extremely expensive, but the cheaper alternative is to have some humans uploaded into a cloud-based virtual reality system, a place where you could spend all eternity living in peace with an avatar of your choosing. Most people already live on the internet, so in most cases, it is just a matter of time?

But, what could come after creating a virtual world? Though this could happen far beyond 2050, we are talking thousands of years; it could be possible. In short, humanity might be able to simulate reality on a universal scale using what is known as a matrioshka brain. Based on the Dyson sphere, a matrioshka brain is a hypothetical megastructure proposed by Robert J. Bradbury. The idea was proposed when imagining the type of highly advanced civilizations that are out there in the universe as this would be an impressive Class B stellar engine, employing the entire energy output of a star to drive computer systems.

Our entire species could be uploaded on this computer system able to simulate reality and remake the universe as we know it. Though this idea may seem far from reality, the idea of uploading the mind to a computer seemed like a distant fantasy at some point.

One of the lesser-known projects that Elon Musk is working on centers around the star-up Neuralink. The company has ambitious plans to directly link brains and computers using a simple, noninvasive device that we can install in our brains. The current fascination with brain-computer interface centers around helping those with neurological mobility issues. However, Musks project extends far beyond that. The eventual goal is to create a "digital superintelligence layer" to link humans with artificial intelligence. As stated in the Neuralink San Francisco presentation, "Ultimately, we can do a full brain-machine interface where we can achieve a sort of symbiosis with AI."

But why stop there? Developments in robotics and prosthetics could open the gates to human-robot hybrids. You may be able to simply go in for a procedure to get bionic eyes, a robotic arm, new legs, etc., all with features that suit your needs and wildest dreams. Just like a toolbox, you could be able to switch out different arms, fingers, and legs for different activities.

Do you think it will be possible for humans to live forever? Share your opinion in the comment section.

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Child-free women are tired of being told they’ll regret it – The Big Smoke Australia

Posted: at 11:44 am

As a woman without a child, Im constantly queried about when the time will be. You know what? Get your mind out of my uterus.

The other day, I was asked (again) whether I was planning to have children. The further I get into my thirties, the more I get asked this question tick-tock and all that. Except this time it was by the guy who came to fix my rowing machine.

We had made small talk for a sum total of a minute and a half when he felt the pressing need to work out how it was possible that I didnt have children by my age and that I really should get to it before it was too late. He didnt say that last bit, of course they never do but that was the implication.

I often wonder why people feel that it is perfectly okay to ask a total stranger about their personal life choices. Perhaps Id spent years trying to get pregnant and it was a trauma that I didnt particularly want to rehash while offering a glass of water to someone who was only in my house because Id paid him to fix something.

Or maybe, just maybe, I dont want children. And I dont care to justify that to anyone, least of all someone I dont know.

Despite the fact that childfree couples are set to become more common than families with kids in the next 10 years, there is still a strange stigma attached to this choice. The question about whether I want children is usually followed up with one about how my partner feels, as though Im doing him an enormous disservice.

I wonder whether, on his own, he is asked so frequently about his childlessness. He doesnt have the disadvantage of a biological clock, after all, counting minutes that usher him closer to that terrible point of no return.

Moving through your thirties, your friendship group starts to get divided up into those with children and those without. You start making friends who are either significantly older or younger, as your peers are no longer out taking dancing classes theyre at home looking after children. An old friend with a young baby once said she didnt approve of my lifestyle choices because I was still going to parties on a Saturday night.

A new friend without children asked me if I was planning to have kids within weeks of us getting to know each other, because she told me frankly that she didnt want to form an emotional attachment to somebody who was going to drop off the map. Ive had other child-free friends express a similar sentiment we all know the difficulties (though not impossibility) of maintaining a close friendship with a woman who has kids.

But even though our demographic is growing rapidly, being childfree is still not treated as a normal thing for women to do. A few years ago, the HuffPost ran an article with the headline: Cameron Diaz Says Shes Completely Happy With Her Choice To Be Childfree as though it was unthinkable that a woman might find joy in something other than parenting. (Would they ever run such a headline about Leonardo DiCaprio, I wonder?)

Recently, a scathing Vanity Fair article about the coastal town of Byron Bay in Australia alerted me to the existence of so-called mommy bloggers and influencers. Clearly Im not their target audience. They tout a return to simplicity, which in effect means dressing their children in linen and refusing to give them phones while they earn a large income from displaying their family lives or rather a perfect version of them all over Instagram.

Their social media feeds espouse a sort of glorification of fertility and parenting, filled with pregnancy photoshoots and staged pictures of their abundance of children (in linen), all similar in age, among magnificent beach backdrops. I am not judging the decision to have children, but the popularity of mumstagrammers seems inherently at odds with demographic trends in Australia, the average per woman is now less than two children.

I do wonder whether they get asked the same questions as me, but in reverse. Does anyone ask them why they decided to have children? Does anyone ask a woman with a child if she will regret her decision? Does anyone imply that her choices make her selfish? Emotionally unfulfilled? Immature?

Last week, while drinking wine on a balcony with my childfree friend on a Friday afternoon (because we can do that any time we want), she commented that there are no role models for women who do not have children. Show us how that can be a fulfilling choice! she practically shouted down to the street.

Show us how women can find rewards in something other than motherhood without it somehow making us less than. Show us how we can be valued as more than our reproductive capabilities. Lets talk about how we can be fulfilled in our work, our creative pursuits, our friendships, and yes even in our relationships with other peoples children that doesnt leave us wanting our own.

There are plenty of reasons why women decide not to have children. I dont have to give you mine.

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Things You Only Know If You’re Childless – And Not By Choice – Grazia

Posted: at 11:44 am

It starts in earnest after Valentines Day. At least, thats when I notice it. However hard I try, I cant ignore the whirlwind of Mothers Day. Every shop window and every chalkboard is promoting it. And in doing so, they offer up the starkest reminder (as if one were needed) that this celebration is for mums... and Im not one. And at 40, having been through five gruelling cycles of IVF and grieved over four miscarriages, its unlikelier with each passing month that I ever will be.

Those experiences serve to make Mothers Day even harder to bear, because if the stars had aligned differently, my husband and I would be chasing around after our three kids and preparing for the arrival of our fourth child.

I dont resent mothers, nor do I begrudge them for being the subject of all this indulgence. Its only one day after all, despite the weeks of build-up. But being childless through circumstance has left a bitter taste. Aside from feeling bereft, its made me painfully aware of my otherness.

The messages society heaps on to women both subliminally and explicitly are that unless youve borne a child, youre less than, incomplete. My journey has been extremely difficult and relentless. Anyone whos travelled the road of infertility and unsuccessful fertility treatment knows that it chips away at you, bit by bit.

It strips you of all confidence, self-worth and purpose, and breaks you utterly. It deprives you of hope and leaves a shell of a person you dont recognise. You do your best to package it all up and put it to one side, so you can get on with life. And Im content, and I know Im blessed in countless ways.

So, every March, I brace myself. I avoid the high street. I stay off social media. I delete unsolicited and unwanted marketing emails.

But when Mothers Day comes around each year, it brings with it a not-so-subtle reminder that Im disenfranchised as a woman. All the grief and anger Ive accumulated trying to have a baby is thrown up in the air and falls down around me, like a game of pick-up sticks.

So, every March, I brace myself. I avoid the high street. I stay off social media. I delete unsolicited and unwanted marketing emails. That task is made easier by the likes of Bloom & Wild, the retailer that gave subscribers the choice to opt out of Mothers Day emails last year, and others that have followed suit. It helps women like me realise were not the only ones who find this day hard. It signals that were getting better at acknowledging that childlessness isnt always a choice; that not everyone who doesnt have kids is childfree by design.

This Mothers Day, Ill surround myself with my husband, my dogs and my own mum, who Im lucky to have. And Ill revel in the fact that, instead of once a year, I can enjoy a lie-in whenever I like.

Things You Only Know If..

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NASAs Hubble space telescope spots quasar tsunamis ripping across galaxies – Fox News

Posted: at 11:42 am

NASAs Hubble space telescope has helped astronomers spot quasar tsunamis ripping across galaxies.

Described as the most energetic outflows ever witnessed in the universe, they emanate from quasars, distant bright objects in space that are similar to stars. The outflows tear across interstellar space like tsunamis, wreaking havoc on the galaxies in which the quasars live, said NASA, in a statement.

Quasars contain supermassive black holes fueled by infalling matter that can shine 1,000 times brighter than their host galaxies of hundreds of billions of stars, NASA explained. As the black hole devours matter, hot gas encircles it and emits intense radiation, creating the quasar. Winds, driven by blistering radiation pressure from the vicinity of the black hole, push material away from the galaxy's center. These outflows accelerate to breathtaking velocities that are a few percent of the speed of light.

NASAS HUBBLE SPACE TELESCOPE SPOTS 'GALACTIC TRAFFIC JAM'

Astronomers were able to study 13 quasar outflows, measuring the incredible speed of gas being accelerated by the quasar wind. This was achieved by looking at spectral "fingerprints" of light from the glowing gas.

An illustration of a distant galaxy with an active quasar at its center. (Credits: NASA, ESA and J. Olmsted [STScI]))

Aside from measuring the most energetic quasars ever observed, the team also discovered another outflow accelerating faster than any other, scientists said, in the statement. It increased from nearly 43 million miles per hour to roughly 46 million miles per hour in a three-year period. The scientists believe its acceleration will continue to increase over time.

Hubble continues to shed new light on space. The telescope, for example, recently spotted a galactic traffic jam more than 60 million light-years away.

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A light-year, which measures distance in space,equalsabout 6 trillion miles.

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A joint project of NASA and the European Space Agency, the Hubble telescope has captured a host of beautiful images since its launch in 1990.In 2012, NASAreleasedan image of a double nucleus in the Andromeda Galaxy that was captured by the Hubble Space Telescope. A Hubble imagereleasedin 2014 showed a double nucleus in spiral galaxy Messier 83.

Follow James Rogers on Twitter@jamesjrogers

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Poem of the week: Antidotes to Fear of Death by Rebecca Elson – The Guardian

Posted: at 11:42 am

Antidotes to Fear of Death

Sometimes as an antidoteTo fear of death,I eat the stars.

Those nights, lying on my back,I suck them from the quenching darkTil they are all, all inside me,Pepper hot and sharp.

Sometimes, instead, I stir myselfInto a universe still young,Still warm as blood:

No outer space, just space,The light of all the not yet starsDrifting like a bright mist,And all of us, and everythingAlready thereBut unconstrained by form.

And sometime its enoughTo lie down here on earthBeside our long ancestral bones:

To walk across the cobble fieldsOf our discarded skulls,Each like a treasure, like a chrysalis,Thinking: whatever left these husksFlew off on bright wings.

In 1986, Rebecca Elson (1960-1999) was a young Canadian astronomer who had begun a post-doctoral research fellowship examining Hubble telescope data at Princeton. In the essay From Stones to Stars, which concludes her posthumously published and single poetry collection A Responsibility to Awe, Elson contrasted the discomforts of working in such a male-dominated environment with her pleasure in the openness and congeniality of Princetons poetry community. But she went on to add a significant qualification, that the discussions there were also a reminder that, although I loved the unlimited licence to invent, I also loved the sense of exploring not an inner, but an outer world, that was really there, in some objective sense. This weeks poem seems to accommodate this dilemma, by working on a borderline between inventive poetic figures and more objective description, while never fully letting go of the former.

The opening lines are simple and striking. The speaker doesnt merely lie on her back to look up at the night sky, as any non-astronomer might do, but, childlike, she eats the stars. She goes on to tell us how she eats them: she sucks them, and finds the taste pepper hot and sharp. This is purposefully visceral and immediate, and a summons to the child star-lover in herself, a tuning-in to the old excitement before academia took over.

She continues the nutrition metaphor with the word stir in the third stanza, but a change of approach is heralded as were invited to follow her into the early universe: No outer space, just space. And now poetic diction is reduced, the whole imaginative process more restrained. The biblical creation narrative is recalled, when the earth was without form, and void yet the description, especially that of the not yet stars, feels logical and objective.

The alternative to stargazing and imagining, proposed in the fifth stanza, is To lie down here on earth / Beside our long ancestral bones Because of the placing of the conjunction in the first line And sometimes its enough the activity is subtly emphasised. Its at least as important as looking up at the stars to be aware of the horizontal neighbourhood, that of our long ancestral bones. The pun on long is beautifully judged here.

Elson doesnt refute biological science. Dead matter is transformed, but kept interestingly visible in the reference to cobble fields / Of our discarded skulls. Its an imaginative truce with fact, followed by speculation, and recourse to the soul-as-butterfly myth. Inevitably, the bright wings connect us to the bright mist in stanza four, as if a new creation might transpire from death.

Antidotes to Fear of Death is undated, and may have been written before the poet was diagnosed with non-Hodgkin lymphoma, the disease from which she died at the age of 39. Its the kind of intense engagement with death that an imaginative young writer might make, regardless of personal circumstance. As an act of generosity, like so much of Elsons work, it includes readers by its imaginative accessibility and universal theme. Although antidote is a strong word, the poem has some power to challenge the individuals fear of extinction with a wider, less egocentric focus on space and time. It lies just outside religious consolation, and just outside scientific detachment. Imagination is all we have to suggest alternative universes, a quality required for survival, for poetry, and for the hypotheses of science.

A Responsibility to Awe was first published in 2001, and was reissued in 2018 as a Carcanet Classic. To read Elsons brave and gentle work during the current pandemic crisis is to take a fresh breath, and to see a little farther.

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10 Great Movies With Fewer Than 10 People in Them – Vulture

Posted: at 11:42 am

The Lighthouse. Photo: A24

So, like everyone else, you now find yourself confined to your home for the foreseeable future. Once youve taken care of necessities like securing a healthy food stock, its time to address the really important question: What kind of movies do you want to watch? Your first impulse might be to watch a bunch of films filled with pleasures you cant enjoy at the moment, like travel, eating in restaurants, or standing within four feet of someone whos not a member of your immediate family. Such movies might offer a pleasant diversion from our new semi-quarantined reality, but they might also just be reminders of happier times.

It could be better to lean into the moment and explore films that deal explicitly with confinement, isolation, and the difficulties of living with others in confined spaces in the midst of crises. And, when doing so, why not choose some that meet the new federal guidelines discouraging gatherings of ten or fewer people? To make it easier for you, weve selected ten great films featuring fewer than ten characters that might, in one way or another, reflect the new reality in which we live.

As many are now discovering, its not always easy living 24/7 in close quarters with anybody, even those you love. Imagine trying it with a bunch of strangers on a boat in the middle of the war. Thats the John Steinbeckcreated scenario at the heart of Alfred Hitchcocks wartime classic Lifeboat, which strands nine strangers (played by Tallulah Bankhead, Home Cronyn, William Bendix, and others) on a lifeboat as the war rages around them. The more we quarrel and criticize and misunderstand each other, the bigger the ocean gets, and the smaller the boat, one character states, but the film is anything but a simplistic plea for peace and cooperation. Not everyones who they claim to be and some characters learn they have to take ugly steps in order to survive. Few directors could move a camera like Hitchcock, but here he proves himself equally effective in a confined space, creating dread and paranoia with a handful of characters drifting through a sea ready to swallow them up if they cant work together to survive. Available to rent on Amazon Prime.

In some respects, the coronavirus crisis has accelerated preexisting trends. For many, telecommuting and interacting with others primarily through technology was already the norm. But just because somethings been normalized doesnt mean it cant distort or even redefine reality. With his 2014 directorial debut, Alex Garland explored the implications of artificial intelligence and the point at which our creations achieved a kind of personhood via the story of an eccentric tech genius named Nathan (Oscar Isaac) who challenges Caleb (Domhnall Gleeson), a programmer in his employ, to find any distinction between his latest creation, Ava (Alicia Vikander) and a human being. But thats only the start of Calebs problems as the experience reveals the full extent of his loneliness and the depth of his need to connect with someone, or maybe something. Using only four characters and an isolated location, Garland digs into the thorny philosophical issues raised by AI while also capturing the ways technology has reshaped the ways we view the world and ourselves, finding little of comfort along the way. Available to stream on Netflix.

Theater has a long tradition of plays featuring only a handful of actors, but that tradition doesnt always translate into great movies. Even a great cast can struggle to make material that worked on stage do the same on the big screen. Adapted from Anthony Shaffers hit 1970 play, Joseph L. Mankiewiczs Sleuth makes a virtue of its smallness, unfolding in the claustrophobic, knick-knack-filled confines of the stately manor occupied by Andrew Wyke (Laurence Olivier), a successful mystery writer with a less-than-successful marriage. Hes joined by his wifes lover Milo (Michael Caine) and the two embark on a battle of wits whose twists and turns are best left unspoiled. The film cleverly draws on the mechanics of classic mystery stories, but at its heart its a nasty character study, brilliantly played by two of the best British actors of their respective generations.

As of now, were all cooped up together for a yet-to-be-determined number of weeks and its not always going to be pretty. But, if were lucky, the experience will never be as ugly as Mike Nicholss adaptation of Edward Albees groundbreaking play in which the middle-aged couple of Martha (Elizabeth Taylor) and George (Richard Burton) play host to young marrieds Nick (George Segal) and Honey (Sandy Dennis). Over one long night, the liquor flows, old skeletons come to light, relationships turn tangled, and everyone emerges from a long-dark-late-night-drinking-session-of-the-soul a little wiser, but also bruised and disturbed in ways that suggest some wisdom can be too hard won. Maybe social distancing has its advantages. Available to rent on Amazon Prime.

Lars von Trier could easily have borrowed the title of the Bergman movie Scenes from a Marriage for this terrifying film, in which a never-named couple (Charlotte Gainsbourg, Willem Dafoe) grieving for their lost child retreat to a cabin in the woods. Attempting to force his wife of her deep depression, the husband subjects her to intense counseling sessions that quickly take a dark turn. Before long, the forest around them starts to mirror her troubled state and their retreat devolves into violence as even darker forces apparently start to take hold. Von Triers apocalyptic Melancholia looks positively upbeat by comparison but, as with that film, von Triers descent into absolute darkness can feelweirdly cathartic. Sometimes depicting a mutilated fox saying Chaos reigns in a spooky voice just feels like an honest expression of how scary the world can turn, and how deep the divide between two people can become. Available to stream on Amazon Prime.

In this largely improvised 2002 film by Gus Van Sant, Matt Damon and Casey Affleck play two hikers named Gerry who slowly come to realize their wanderings have taken them so far off the trail they might never find their way back. Inspired by Hungarian filmmaker Bla Tarr, Van Sant uses long shots and stark landscapes to convey a sense of isolation and mounting fear as Gerry and Gerrys journey starts to take on an existential quality. With death at hand, their relationship begins to fray as they realize how much they depended on the comforts and dependability of civilization, both to survive and to define themselves. Van Sants refusal to cut away from their long desert trudges works both as stylistic bravado and an act of empathy, forcing viewers to consider the experience of human existence when its been stripped to its essence. Available to stream on Tubi.

Beyond the influence of Tarr, Gerrys use of blurring identity also owes a debt to Persona, Ingmar Bergmans quintessential study of bleeding identities. Liv Ullmann stars as Elisabet, a famous actress whos stopped speaking, either out of inability or desire. When shes sent to a remote cottage with her nurse Alma (Bibi Andersson), their relationship becomes by turns intimate and violent. As secrets from their pasts surface, the lines dividing their personalities start to blur, a process Bergman depicts via stunning compositions and aggressive editing as attuned to the French New Wave as his past work. Its a fascinating study of intersecting lives that works just as well as a kind of psychological horror movie. Pair it with this next film and youve got yourself a terrific, disturbing breakdowns-by-the-seaside double feature. Available to stream on Amazon Prime.

As many of us struggle to adjust to telecommuting, its probably best to remember that having to work side by side with the wrong co-worker can be hellish. For his follow-up to The Witch, Robert Eggers sends a young 19th-century lighthouse keeper (maybe) named Ephraim Winslow (Robert Pattinson) to an isolated New England island to work alongside the more experienced Thomas Wake (Willem Dafoe). Once there, Winslow learns the place has an odd history, starts to experience strange visions of tentacles and mermaids, and develops a complicated (to say the least) relationship with Wake. Shot in striking black-and-white and accompanied by a disorienting sound design, Eggers film builds in hallucinatory intensity until its not clear whats real, whats imagined, and how much blame for the ensuing weirdness and its dire consequences can attributed to the difficulty of spending too much time with one person. Available to stream on Amazon Prime.

On the other hand, Dr. Ryan Stone (Sandra Bullock), the protagonist of Alfonso Cuarns 2013 film Gravity, seems to have a lovely working relationship with Lieutenant Matt Kowalski (George Clooney), her companion on a space shuttle expedition intended to repair the Hubble Telescope. But circumstances beyond their control cut that relationship short, forcing Stone to take extraordinary measures as she looks for a way to make her way back down to Earth. Shot in 3D and widely watched on IMAX at the time of its release, Cuarns film is a technical wonder. But it also plays well at home, in part because of Cuarns extraordinary command of visual storytelling and in part because of Bullocks gripping performance. Over the course of the film, we learn of the loss that made it easy for Stone to take to the stars and the lasting grief that now makes it easy to entertain the thought of just drifting away. But its ultimately a story of survival, and how the will to live can persist and prevail in even the most impossible circumstances. Available to stream on Amazon Prime.

In that respect, Gravity bears a strong resemblance to another 2013 film anchored by an exceptional bit of acting, J.C. Chandors nautical survival tale All Is Lost. Robert Redford stars as an unnamed man who awakens in the middle of the Indian Ocean to find his boat already pretty far along in the process of sinking. In a virtually wordless performance, Redford captures the characters deepening commitment to make it out alive and return to a life on shore one reflective scene suggests hes made a mess of before disembarking. Like Gravity, its an impressive technical accomplishment, but also one that would mean nothing without Redfords deft performance as a man who may not have understood just how much he wanted to live until staring death in the face. Available to stream on Hulu.

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10 Great Movies With Fewer Than 10 People in Them - Vulture

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Gene editing might help restore extinct plants used as food, medicine and perfume thousands of years ago – Genetic Literacy Project

Posted: at 11:41 am

We debate the ethics of reviving extinct species like the passenger pigeon orwoolly mammoth, with scientists clamoring to make some poor, hairy proboscidean clone baby take its first awkward steps out onto the ice. Yet somehow, the idea of resurrecting long-lost plants never really caught on in the public imagination.

Maybe thats because most people probably couldnt even name an extinct plant, let alone one theyd want to smell, see, or study, though Rachel Meyer, an assistant professor of ecology and evolutionary biology at the University of California, Santa Cruz, has a hard time picking just one.

Theres a broad, storied slate of lost plant species and varieties that have been sort of forgotten that maybe we want again, she said, and its looking increasingly likely that we could bring these things back.

While trying to sprout old seeds may not be a great bet, [Dorian Fuller, a professor of archaeobotany at University College, London], sees possibilities in combining gene-editing technology like CRISPR and advances in recovering DNA from historical specimens. Theoretically, he said, You could take genetic material out of an ancient plant and insert it into a modern seed.

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A new AI system has enabled the discovery of a novel role for ‘smell-sensing’ genes in colon cancer – Healthcare IT News

Posted: at 11:41 am

Humans havearound400olfactorysmell-sensing genes the largest gene familyin humansthat are turnedon in the noseand other parts of the body, allowing us to smell at least one trillion different odours.Up until now, the role of theseolfactorygenes outside the nose has been largely unknown.

A recent study, published in Molecular Systems Biology, usedmultiple layers of artificial intelligence (AI) toidentifythesegenes involved inthe organisation ofcolon cancer cells. Thisrevealed thatsmell-sensinggenescancontribute to this cancer-associated processalong with keycoloncancer genesandhighlighted their potential role indisease spread andprognosis.

The discoverywas enabled by thedevelopmentof an innovativeAI system, calledKnowledge-and Context-driven Machine Learning (KCML)that enables researchers to studymicroscopy imagesin greater detail to understand more about the function of genes in specific context. KCML has first been applied to colon cancerbut is widely applicable in other diseases too.

The researchers usedcomputer vision algorithm to detect changes in cell appearance and organisation. The algorithm was fed information from robotic microscopy, in collaboration with researchers from the University of Zurich, to image millions of colon cancer cells.By reducing the expression of the smelling genes within these cells, they were able to understand more about the role they play in carcinogenesis.

Expression is whengenes are activated to produce certain proteinsand molecules. Researchers in this study found that reducing the expression of smell-sensing genes in colon cancer cells, a process known as perturbation,can inhibit cells from spreading, potentially by restraining the ability of cells to move. The same behaviour is also observed in the perturbation of key cancer genes.

Dr Heba Sailem,Sir Henry Wellcome Research Fellow at theInstitute of Biomedical Engineering in the UK, alead author on the study,explained: With all this big imaging data, we have a powerfulmeans tobetter understand how every single gene contributes to cancer cell behaviour. I have developed an AI system that is guided by prior knowledge of gene function that allows us to learn much more from this data than would be possible using existing methods.

When humans look atcomplex scenes, theyinterpret the images in light of their previous experience and visual memories (prior knowledge). However, computersjust seeimages asalargematrix of numbers, they will not see shapes and structures.Computer vision is about training the computer to see whatthe human can see. Through AI, we are able to identifyhow turning genes off affectsthe characteristics, shape and structureof cells and tissue. Usually, it is a very lengthy process for humans to interpret numbers from thousands of images, each with thousands of cells.Computer vision can achieve that in a few days,she added.

Dr Sailemswork has focussed on studying cells in culture, and the next step will beto link these findingsthroughto real patient data. She is also keen to apply her AI modelto study the behaviour of genes indifferent cancers, including prostrate, breast and lung.

WHY IT MATTERS

Colorectal cancer is the third most common cancer in the UK and the second most common cause of cancer deaths.

Professor Mark Lawler, chair in translational cancer genomics, Centre for Cancer Research and Cell Biology, Queens University Belfast and Bowel Cancer UK medical advisor,welcomed the application of the new AI model in colorectal cancer, commenting the study showed the power of data in revealing new mechanisms.

One of the biggest challenges in colorectal cancer is metastasis. This is the point at which most patients die. Something that tells us more about that and maybe indicates how this could be controlled is verypromising, he added.

Dr Sailem explained:Cancer is not one disease - itcan be classified intomany diseases depending ontissue type and origin. Wecan takecellsfrom diseased tissueand look at what the genes in theseparticular cellsare doing. We can then identify genes to target for therapy or genesfor which targeted therapies already exist.

THE LARGER TREND

AIand machine learningis increasingly being used to acceleratethe development oftargeted therapies in cancer and other diseases, with leading technology and pharmaceuticalcompanies forming high profile partnerships in recent months.

One such collaboration between Novartis and Microsoft was announced in October to transform medicine with AI. Vas Narasimhan, CEO of Novartis, said, As Novartis continues evolving into a focused medicines company powered by advanced therapy platforms and data science, alliances like this will help us deliver on our purpose to reimagine medicine to improve and extend lives. Pairing our deep knowledge of human biology and medicine with Microsofts leading expertise in AI could transform the way we discover and develop medicines for the world.

ON THE RECORD

Professor Tim Maughan,professor of clinical oncology at the University of Oxford and advisor to Bowel Cancer UK,saidDr Sailemsstudy linked to his own research into howcellswithin tumourstalkto each other.

He said: What they say to each other is determined by molecular make up but also by the conversation going on between the cells. The shape that the cellshave, theway that theyareorganised, the distance they are apart, how close the immune cells get into the cancer,is all a result of the conversation going on between the different cell types within a cancer

DrSailemin this study has found that inadditiontoidentifyingwhole new genes which are important in bowel cancer, she has also picked up that genes that are part of thatolfactorysmell system play a part of this conversation.

Commentingon the research, Professor Lawler said:It is saying something about why there areolfactorygenes in other parts of the body and how they might be responding to the microbiome in the gut. It will be interesting to see what stimulates these genes to upregulate or down regulate in their environment. From there we may be able to identify important biomarkers.

He added: Big data for better health makes sense. You can use that data to change lives, diagnose patients earlier, develop better treatment and improve their quality of life and above all, data can really save lives.

For more information on bowel cancer go to http://www.bowelcanceruk.org.uk.

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A new AI system has enabled the discovery of a novel role for 'smell-sensing' genes in colon cancer - Healthcare IT News

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Invitae and Muscular Dystrophy Association (MDA) Expand Access to No-Charge Genetic Testing in the US and Canada – PRNewswire

Posted: at 11:41 am

SAN FRANCISCO, March 23, 2020 /PRNewswire/ --Invitae (NYSE: NVTA), a leading medical genetics company today announced its partnership with the Muscular Dystrophy Association (MDA) to offer sponsored, no-charge genetic testing to patients through the Detect Muscular Dystrophy program in MDA's care center network, a network of clinics at more than 150 of the nation's top healthcare institutions.

Research has shown no-charge testing programs help increase utilization of genetic testing, which can shorten the time to diagnosis by as much astwo years in some conditions. Accurate diagnoses enable clinicians to focus on providing disease-specific care sooner, helping reduce costs and improve outcomes.

"Muscular dystrophy consists of many disorders with overlapping symptoms that often make diagnosis more challenging. Genetic testing can help accelerate diagnosis and treatment of conditions such as Duchenne Muscular Dystrophy or Becker Muscular Dystrophy which enables clinicians to begin identifying treatment options sooner," said Lynn O'Connor Vos, President and CEO of Muscular Dystrophy Association. "By bringing this program to our care centers, we can make it easier for patients to get tested, moving them one step closer to the care they need."

Muscular dystrophy refers to a group of disorders characterized by progressive muscle weakness and loss of muscle tissue. Muscular dystrophies affect 1 out of every 4,000 to 5,000 people with varying severity and presentation, often affecting skeletal muscle and ambulation, and in some forms involving cardiac, respiratory, swallowing muscles or other organs and tissues. Genetic testing has been proven to shorten the time to diagnosis and prevent misdiagnosis. Accurate and early identification of affected individuals allows for improved clinical outcomes.

In addition to genetic testing, the Detect Muscular Dystrophy program offers post-test genetic counseling to help patients understand test results and make more informed decisions about their health and follow-up care. Detect Muscular Dystrophy also offers genetic testing to family members of patients with genetic variants associated with disease to better understand their own disease risks.

"Genetic testing can expedite making an accurate diagnosis, facilitate earlier interventions, allow genetic counseling of family members, and support clinical research into muscular dystrophies, including Duchenne and Becker muscular dystrophies, and also many other forms of muscular dystrophy," said Robert Nussbaum, M.D., chief medical officer of Invitae. "We're proud to work with MDA to increase access to early genetic testing among patients suspected of having muscular dystrophy. Their network of care centers offers patients expert care and easier access to genetic testing to inform that care."

Additional details, terms and conditions of the programs can be found at Detect Muscular Dystrophy (www.invitae.com/DetectMD). For more information on partnering with Invitae, visit http://www.invitae.com/biopharma.

Invitae sponsored testing programs are designed to increase access to genetic testing, particularly in conditions where earlier testing can improve diagnosis and treatment yet testing remains underutilized. Patients enroll in Invitae's sponsored testing programs through their clinician. Learn more atwww.invitae.com/sponsored-testing.

About Muscular Dystrophy Association Since 1950, the Muscular Dystrophy Association (MDA) has been committed to transforming the lives of people affected by muscular dystrophy, ALS and related neuromuscular diseases. We do this through innovations in science and innovations in care. As the largest source of funding for neuromuscular disease research outside of the federal government, MDA has committed more than $1 billion since our inception to accelerate the discovery of therapies and cures. Research we have supported is directly linked to life-changing therapies across multiple neuromuscular diseases. MDA's Neuromuscular ObserVational Research (MOVR) data hub gathers longitudinal clinical data for multiple neuromuscular diseases to improve health outcomes and accelerate therapy development. MDA supports the largest network of multidisciplinary clinics providing best in class care at more than 150 of the nation's top medical institutions, and our national resource center serves the community with one-on-one specialized support and we offer educational conferences, events, and materials for families and healthcare providers. Each year thousands of children and young adults learn vital life skills and gain independence at summer camp and through recreational programs, at no cost to families. For more information visit mda.org.

About InvitaeInvitae Corporation(NYSE: NVTA) is a leading medical genetics company, whose mission is to bring comprehensive genetic information into mainstream medicine to improve healthcare for billions of people. Invitae's goal is to aggregate the world's genetic tests into a single service with higher quality, faster turnaround time, and lower prices. For more information, visit the company's website atinvitae.com.

Safe Harbor StatementThis press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including statements relating to the benefits of genetic testing and information; and the design and benefits of the company's sponsored testing and Detect programs. Forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially, and reported results should not be considered as an indication of future performance. These risks and uncertainties include, but are not limited to: the company's history of losses; the company's ability to compete; the company's failure to manage growth effectively; the company's need to scale its infrastructure in advance of demand for its tests and to increase demand for its tests; the company's ability to use rapidly changing genetic data to interpret test results accurately and consistently; security breaches, loss of data and other disruptions; laws and regulations applicable to the company's business; and the other risks set forth in the company's filings with the Securities and Exchange Commission, including the risks set forth in the company's Annual Report on Form 10-K for the year ended December 31, 2019. These forward-looking statements speak only as of the date hereof, and Invitae Corporation disclaims any obligation to update these forward-looking statements.

Contact:Laura D'Angelo[emailprotected](628) 213-3283

SOURCE Invitae Corporation

http://invitae.com

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Invitae and Muscular Dystrophy Association (MDA) Expand Access to No-Charge Genetic Testing in the US and Canada - PRNewswire

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