Monthly Archives: January 2020

MERIDEN, Conn. (WTNH) A cold case has been haunting the Meriden Police Department for 32 years, but officers are hoping a new partnership and DNA testing may cause their trail to warm up.

The case involves newborn David Paul. Police said the baby was left to freeze to death in the AGC parking lot on Evansville Avenue.

He was found dead on Jan. 2, 1988. According to the Harford Courant, his umbilical cord was still dangling from his stomach.

Each year, the department holds a memorial service for David, who was named by local clergy.

But this year, the memorial has something that past services didnt have: hope.

On Monday, the department announced it has been working with DNA Doe Project, a California-based company, to try and find Davids mother.

The company specializes in trying to identify unidentified victims from older cases in which its difficult to obtain DNA.

The announcement comes as a ray of hope to residents who remember the day David was found.

Tammy Hoffman lived next to the lot where David was found. She said she still remembers officers knocking on her door that tragic day.

It was a knock at the door, and it was one of the police officers that was responding and making us aware of the fact that a baby had been abandoned in the lot next door to my house, she recalled to News 8.

After hearing the news, Hoffman said shes hoping it can bring an end to this cold case.

I never did give up hope DNA doesnt lie, Hoffman said. Many times it can lead to a happy reunion amongst family members; people you didnt even know you were related to. It can help you find out what your genetics are, and it can also find out who the bad guy was.

And she knows that finding that bad guy is a top priority for the department.

Many officers will have that one case that they just wish they couldve solved, and I know for a lot of members of our Meriden police department this is that one case.

According to the Courant, in 2001 police sent 13 pieces of evidence to the FBIs crime lab in Quantico, Va., for DNA analysis. Among them were the blankets David was found wrapped in that fateful day.

Investigators believe his mothers DNA could be on them and hope that new DNA technology can help identify and track her down.

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Cracking a cold case: Meriden PD using DNA testing to find mother who left newborn to freeze to death in parking lot 32 years ago - WTNH.com

Data is a massive problem for the intelligence community. From the satellite images produced by the National Reconnaissance Office to the bulk communications data swept up by the National Security Agency, the intelligence community is collecting more information than ever before. But where to store it?

Data centers are massive warehouses and megawatts of power. The resource-intensive nature of these facilities makes them difficult to scale, and ultimately unprepared for a torrent of data.

Now, the Intelligence Advanced Research Projects Activitythe organization charged with tackling some of the intelligence communitys most difficult problemsthinks it has a solution: synthetic DNA. On Jan. 15, IARPA officially launched the Molecular Information Storage (MIST) program, an effort to use synthetic DNA to store exabytes (one million terabytes) of data.

IARPA has awarded multi-phase contracts to two teams pursuing a solution: up to $23 million for the Molecular Encoding Consortium and up to $25 million for Georgia Tech Research Institute.

The MIST program is a data storage moonshot to develop technologies that allow us to shrink an exabyte-scale data warehouse down to a tabletop form factor, with equally large reductions in operation and maintenance costs, said IARPA Program Manager David Markowitz. This would be a transformative capability for big data stakeholders in government and industry.

If successful, MIST will result in new devices capable of both writing data to and reading data from synthetic DNA media at scale. The goal is to make this technology commercially viable within three to five years.

To store data on synthetic DNA, digital files must first be converted from binary code to the format used for DNAsequences of A,C,T and G. DNA is then synthesized in short segments that are identified by a sort of barcode that identifies where that segment exists in relation to the entire sequence, allowing readers to recall or copy only the necessary data.

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With digital data growing at an exponential rate, there is increasing interest and excitement about using natures storage medium, DNA, to store digital data, said Emily Leproust, CEO and co-founder of Twist Bioscience, one of the companies working with the Georgia Tech Research Institute. With the governments commitment to fund this exciting new area of storage, we believe that as part of this consortium of specialists, we can truly revolutionize the DNA synthesis process, and reduce the cost of synthesis for DNA data storage by many orders of magnitude.

According to Twist Bioscience, the goal of their effort will be to create a device capable of writing enough synthetic DNA per day to reduce data storage costs to as low as $1 per gigabyte.

Fifty years ago, DNA data storage was considered science fiction today, it is science with a path toward broad implementation, Leproust said. We expect in the next three to five years, with the proper amount of government and industry investment, it will become a reality for long-term storage.

The Molecular Encoding Consortium is led by the Broad Institute of MIT and Harvard and includes DNA Script and Professor Donhee Hams research group at Harvard University.

Meanwhile, the Georgia Tech Research Institute is teaming with the Twist Bioscience Corp., the University of Washington, Microsoft and Roswell Biotechnologies for their effort. These new systems will be tested independently by Los Alamos National Laboratory, Sandia National Laboratories and the U.S. Army Research Laboratory .

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Where to store all this intelligence data? How about DNA? - C4ISRNet

As skincare aficionados, were always on the lookout for the next best thing in anti-aging. While we love bakuchiol, ceramides, and retinol as much as the next person, sometimes it seems like our skin just needs more. Feel the same? One solution is to turn your attention to epigenetic skincare.

If youre sitting here reading this thinking, epige-what? youre not alone. While epigenetic skincare still needs to be more heavily researched, according to FightAging.org, the general consensus according to is that, since most people experience the appearance of aging due to the same external factors (think: diet, sun exposure, and the like), its possible to study the epigenome to uncover the patterns that are linked with age. By uncovering these patterns, cosmetic chemists can develop products that interact epigenetically to deliver your youngest, most radiantly-looking complexion.

Sounds pretty dreamy, right? To learn more about the high-tech approach, sit down, mute your notifications, and get ready to soak in a whole lot of science in an effort to say hello to your most effective skincare routine.

What is epigenetic skincare?

First things first, lets talk epigenetics as a whole. Scientifically speaking, Olays Principal Scientist, Dr. Frauke Neuser explains that epigenetics describes the study of gene regulation and behavior which happen without any alteration of the genetic code (DNA) itself. In laymans terms, BeautyStats founder and CEO Ron Robinson says, epigenetics is the science behind the fact that environmental factors can affect the expression of genes.

To illustrate this idea, Neuser points out how the genes in the skin that are responsible for collagen production become less active with age, but can also become less active due to external factors, like sun exposure and air pollution. As such, Epigenetic skincare is based on the concept that skincare ingredients can affect gene behavior and counteract undesirable increases or decreases in activity by switching certain genes on or off (although turning genes up or down, like a dimmer light switch, might be the better analogy), he says.

How does epigenetic skincare work differently than traditional formulas?

In short, epigenetic skincare is designed to dive far beyond traditional formulas to not only affect the cellular level but the genetic one, too. While epigenetic concoctions complement traditional formulas, Neuser explains that certain skincare ingredients work directly on skins behavior and appearance while also having the potential to affect skin cells at the gene activity levelwhereas others might only do one or the other. It is usually a combination of ingredients that can achieve the best benefits, he adds. For example, about two years ago, Olay added a new ingredient (carob seed extract) to its Regenerist Micro-Sculpting Cream, accompanying already present niacinamide (vitamin B3) and peptides, based on gene activity studies that showed complementary effects. Clinical studies confirmed the desired anti-aging benefits.

Whats worth noting, however, is that even though brands (Olays not the only one) are uncovering the perks of epigenetic skincare, Robinson points out that theyre not actually allowed to claim that the products work on the genetic level, as that gets into drug territory as determined by the FDA. Thats why so many epigenetic formulations speak to the cosmetic benefits of the product, as opposed to genetic.

What are the benefits of epigenetic skincare?

Along with deep dives into the skin comes the ability to address complexion concerns from an all-encompassing stance. In theory, the idea is to help skin help itself by regulating processes that naturally occur in skin, as opposed to purely relying on extrinsic actives to help and improve skin health and appearance, Neuser says.

In December 2016, scientists at the Salk Institute in La Jolla, California, found that, after focusing on epigenetic markers and intermittently altering the genes in mice with progeria, a genetic disease that affects both animals and humans, mice appeared younger and healthier. While mice and humans are two very different things, the researchers concluded that it could lead to positive anti-aging effects for humans, too. (Though, they do note that more research is necessary to reach clinical trials.)

This work shows that epigenetic changes are at least partially driving aging, says Paloma Martinez-Redondo, a Salk Institute research associate and co-author of the study. It gives us exciting insights into which pathways could be targeted to delay cellular aging.

And the Salk scientists arent the only ones who have found promise with epigenetic research. In a September 2018 article published in the SOFW Journal, principal authors found that by targeting epigenetic mechanisms, specific anti-aging ingredients can positively affect the skin, essentially reversing the aging clock to make way for a younger-looking complexion.

Are there any downsides or side effects of using epigenetic skincare?

Downsides are largely undocumented given the shallow pool of research of epigenetic skincare. However, given its tailored directly towards specific genes that affect aging, and it requires elaborate research to even launch, consumers can typically have faith in a quality product that wont cause irritation when they do come across one.That said, its important to understand that creating epigenetic skincare products is a super complex process, so there arent tons of options on the market, in the first place.

At Olay, we have been studying gene activity in skin for over 20 years, because identifying individual genes among the tens of thousands of genes present in our skin cells, and understanding how they work and interact, is the first big step on the epigenetic skincare journey, Neuser explains. Highly complex and sophisticated methods are needed to study gene activity and make sure any changes measured are really relevant and significant.

With that in mind, below youll find four highly-rated epigenetic skincare products. While more science is necessary on the subject, we think the sky-high reviews make testing this seriously-scientific self-care well worth it.

With over 50 million jars sold, its safe to say this drugstore product is a must. Its made with vitamin B3, amino-peptides, hyaluronic acid, and antioxidants to address aging concerns topically and deep down10 layers to be exact. While they cant promise gene mutation, they do ensure a noticeable change in the appearance of your skin when used regularly for 28 days straight.

BABOR has done extensive epigenetic research to create their entire Skionvage system, which is focused on the brands Power Peptide to help the skin resist outside factors like sun exposure, pollution, and free radicals as a whole. This cream, in particular, is a dream for reactive skin types, as it reduces redness and calms the complexion on a deep level.

Courtesy of Augustinus Bader

Its important to remember that body care requires skincare too, after all, we do have skin on our bodies. The Augustinus Bader body cream fulfills the basic requirement of moisturizing skin, but what makes this anti-aging body product stand out is that it uses its epigenetic technology to target and treat stretch marks and cellulite with continued use.

Courtesy of Sisley Paris

With heavy research into behavioral aging, Sisley launched this anti-aging serum that tightens, lifts, and smooths skin for a younger-looking appeal. While the price is high, the reviews make it seem well worth it.

See more here:
Epigenetic skincare can actually change your DNAheres what you need to know - Yahoo Lifestyle

ALBUQUERQUE, N.M. (KRQE) An arrest has been made in a four-year-old cold case in Albuquerque, thanks to genealogy matching DNA taken after a crime, to DNA submitted by family members to an ancestry tracking company.

Angel Gurule, 23, is accused of raping a woman on a trail more than four years ago. Thursday, the Bernalillo County District Attorney says hes hopeful this new investigative approach is the start of cracking more cold cases.

There was DNA recovered from the scene, there was a description of the offender turned in to law enforcement, District Attorney Raul Torrez said at a news conference Thursday.

According to court documents, on Christmas Eve 2015, Gurule tackled and sexually assaulted a jogger on a trail along the Rio Grande near Rio Bravo. The victim then went to the Rape Crisis Center and went through a sexual assault examination.

The Bernalillo County Sheriffs Office opened an investigation but had no leads for years because no suspects ever showed up in the government database, known as CODIS, that contains DNA from convicted felons. That was until the DAs office got a federal grant last summer to use whats called DNA genealogy technology that dives into a bigger system of DNA from ancestry sites like 23 and Me.

Then, finally, in November of last year, Gurule was identified as a potential suspect in the rape after investigators found distant family members of his through an ancestry kit. Investigators tracked him down to Kaseman Hospital where he was visiting his wife.

When the couple left, investigators grabbed Gurules styrofoam cup to test his DNA, and it was a match. The sheriffs office arrested Gurule on Wednesday at his home just about a mile from where the attack happened.

He admitted to it. We even took him out to the actual trail and he walked us through where he saw the victim, where he attacked her, lead investigator Kyle Hartsock said.

At the time of the incident, Gurule was 19 and a recent graduate of Sandia High School where he was on the cross country team.

Gurule is also named as a suspect in the sexual assault of a 14-year-old girl in a separate case that happened just three months before the other rape. KRQE News 13 asked the DAs office about that case and whether anyone dropped the ball, but did not receive a response.

Thursday, a judge ordered Gurule to stay behind bars for now on a no-bond hold.

The DAs office says it will be asking state lawmakers for funding so they can help crack more cold cases with this genealogy testing. The labwork alone in this case cost $7,000.

Continue reading here:
Genealogy matching used to make first arrest of its kind in New Mexico - KRQE News 13

Cleveland It was in a cellar that I found my roots. Davina Shuman, a relative I never met, graciously gave me a glimpse of the family I never knew I had.

The Levys were a conservative, Jewish family from Cleveland. Their patriarch, Harry Levy, is my great-grandfather. In the spring of 1930, one of his four daughters we don't know which gave birth, out of wedlock, to my mother. Davina, one of Harry's legitimate grandchildren, says no one ever knew about this baby.

"It would be scandalous, really, in those days, for this family," Davina said.

My mom died knowing none of this. She was raised by another couple. There was no formal adoption or paper trail. So if not for DNA testing, my ancestry would have remained a secret. My results revealed two relatives, leading me to some new discoveries.

A recent survey showed about a quarter of the people who take these tests find some kind of surprising result. Or in my case, two surprising results. The test was more definitive regarding my grandfather. He was an Irish Catholic railroad worker named Frank Black.

His other daughter, Carol, is my new aunt. My uncle is also named Frank Black. Together, they told me all I needed to know about my grandpa. Frank said he had five wives. Carol said he was a drinker. Not exactly the astronaut or war hero I was hoping to find.

"We were the apples that fell off the tree and rolled away," Carol said.

It certainly does make you question who you are. I grew up an Eagle Scout who went to Catholic school. Now I find my grandpa was Casanova, and the Levys were Jewish.

"If your mother is Jewish, you are Jewish, no question," Davina said.

But my new relatives all told me none of that matters.

"I just want you to come for Thanksgiving," Davina said.

Look deep enough into your past and odds are you'll find a family tree full of flowers and broken branches and a lot of leaves you don't recognize. But I think it's important to embrace it all because whatever is there, it's exactly what your tree needed to grow the perfect you.

To contactOn the Road, or to send us a story idea, email us:OnTheRoad@cbsnews.com.

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How a DNA test revealed the family I never knew - CBS News

DNA identifies mother of infant found frozen in 1988

Updated: 5:55 PM EST Jan 14, 2020

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NEWSROOM WITH THESE NEW DEVELOPMENTS. REPORTER: DNA LINK THAT CHILD TO DISTANT COUSINS AND POLICE SAY THE MOTHER HAS NOW CONFESSED, TELLING THEM SHES BEEN WAITING FOR 32 YEARS FOR POLICE TO KNOCK ON HER DOOR. KAREN KUZMAK ROCHE WAS 25 IN 1998 WHEN SHE LEFT HER NEWBORN BABY IN A CONNECTICUT PARKING LOT. SHE SAYS SHE CALLED THE FIRE DEPARTMENT, TELLING THEM TO LOOK FOR SOMETHING IN THAT PARKING LOT, BUT NEVER MENTIONED IT WAS A CHILD. POLICE DID NOT FIND THE BABY UNTIL DAYS LATER. OFFICERS NAMED HIM DAVID AND HELD A CEREMONY EVERY YEAR TO REMEMBER HIM. NOW, CRACKING THIS CASE THANKS TO FORENSIC GENEALOGY. >> WE LIVE IN A REVOLUTION IN HUMAN IDENTIFICATION. THERE ARE A LOT OF CONTROVERSIES OVER USING GENEALOGICAL DATA FOR THIS KIND OF CASE, BUT YOU CAN SEE WHERE IT GOES. I DONT BELIEVE THERES ANY CLOSURE, BUT THERE IS RELEASE. REPORTER: ROCHE IS NOT FACING ANY CHARGES AT THIS TIME. POLICE SAY THEY DID LOOK

DNA identifies mother of infant found frozen in 1988

Updated: 5:55 PM EST Jan 14, 2020

VIDEO: 32 years after the newborn was found frozen to death in a Connecticut parking lot, police now know who he was and have identified his mother.

VIDEO: 32 years after the newborn was found frozen to death in a Connecticut parking lot, police now know who he was and have identified his mother.

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DNA identifies mother of infant found frozen in 1988 - WCVB Boston

PHOTO:Duncan Hull

Salesforce created the customer relationship management (CRM) software market as we know it today, and with the rise of Salesforce CRM for B2B sales teams, CRM became a sales tool that tracks opportunities through various sales stages. But CRM's humble beginnings date back to the 1980s, when the market for contact management software was starting to heat up. ACT! was a key player in this growing market, followed by companies such as Goldmine that competed with ACT! for a share of a massive market opportunity. The technology soon morphed into salesforce automation, and in the '90s was firmly established as an irreplaceable tool for sales teams.

CRM was later reclaimed by marketers and B2C brands to bring together customer journey data. If all that data was on one CRM, theoretically, marketers could gain insights from the data and use it to power automated engagement. However, CRM posed some limitations (limited integrations, no real-time capabilities) and this demand for insight into and activation of centralized customer data is what gave rise to customer data platforms (CDPs).

CDPs excel at creating a single view based on customer journey data from multiple sources, then cleansing, deduping and stitching it together to provide marketers with accurate data from which they can derive important customer insights to make important business decisions, and use this data to intelligently orchestrate experiences across channels.

As CRM platforms evolved, they diverged into two disparate types, operational and analytical:

Related Article: Customer Data Platforms Shine Where CRMs Fail

We, and other CDP vendors, owe a lot to the popularity of analytical CRM platforms. In many ways, CDPs are essentially an analytical CRM advanced to meet the scale, configurability, and real-time needs of todays enterprise brands. CDPs are now more popular than ever, growing 65% in 2018. According to the CDP Institute, industry revenue reached $740 million, up more than 50% from 2017. By the end of 2019, revenue was expected to exceed $1 billion.

One of the key reasons CDPs have gained so much market traction is because of the need for an analytical CRM, which is capable of handling real-time web events. The idea of an analytical CRM / customer data platform is not a new concept. In one form or another, it has existed for the last 50 years, defined as customer databases or marketing databases.

In the past, these traditional databases coupled with marketing service providers have been somewhat able to meet the analytical CRM needs of marketers. But as the size, shape and currency of customer data exploded with the growth of the internet, use of smartphones, and thousands of marketing tools and customer engagement channels, a traditional database with a services team enhancing it was no longer sufficient. This, plus the need to compete with Amazon by providing hyper-relevant customer experiences, paved the path for the CDP.

Todays customers now have endless transactional, profile-based, and event data sets that are important for marketers to understand. And this massive size of data, along with the need for marketers to be able to leverage data in real-time which traditional analytical CRMs didnt support drove analytical CRM systems into the cloud and was the impetus for the CDP industry.

The market for CRM platforms and CDPs diverged and now serve different purposes and use cases. Whats new about CDPs is they are built on modern SaaS architecture to be infinitely scalable, with high performance, and to support real-time use cases while giving marketers, data scientists, business users and anyone within the organization who needs it, direct access to customer data and intelligence. CDPs are the best that an analytical CRM has to offer, with all the benefits of an extensible SaaS platform, fast data processing, and modern APIs.

Related Article: Keep Your Eye on CDP Platforms: They'll Be Worth $1B by 2019

Omer Artun is the Chief Science Officer at Acquia. He was previously the founder and CEO of AgilOne, which was acquired by Acquia in December 2019.

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Customer Data Platforms and Analytical CRMs Share the Same DNA - CMSWire

Source: WENN/Avalon / WENN

We know that Tia Mowry-Hardrict, one half of the famous Mowry twins of course, is the child of a Black mother (Bahamian by the way) and a white father (European, Irish as far as she knew), but she shared some new insight into where her family comes from by revealing her recent DNA test results.

She didnt specify who was behind the particular DNA test she did, but she did show fans the steps she took from start to finish, sharing the results of her test four weeks later on her YouTube show, Tia Mowrys Quick Fix.

As it turns out, her fathers people are British, Irish, German, French and Scandinavian.

As for her moms side, Tia found out that her mothers people originated from West Africa, specifically Ghana and Nigeria.

What up my Nigerians! she remarked. One of my really, really good friends is Nigerian. Its just so amazing to really know the fine details of where your ancestors were from.

Still, the 41-year-old actress said she did the test because she wanted to find out more about where her father came from.

One of the main reasons why I wanted to do this is because as Ive gotten older, Ive been more intrigued with who I am and where I come from, she said. Ive always known some information about my moms side, but I didnt know a lot about my dads side. My dad is white and when my mom and my dad got married, on my dads side, there wasnt a lot of support until now.

Shes since found family members on her dads side on social media, even meeting a second cousin in person. Shes also gained, through her results, a great sense of pride in her ancestors and their show of strength, from the Irish migrating to the U.S. during their great famine to her Nigerian and Ghanaian predecessors overcoming slavery. At one point, Tia teared up when breaking down the gratitude she has for both sides of her family.

I have both sides of me that are just badass, she said. That explains why I am such a go-getter and why Im jut so aggressive in whatever I want and I just dont give up.

She also learned about her susceptibility to certain health issues because of her familys background.

My results said slightly increased risk for late onset Alzheimers, she revealed. I got chills because my great grandmother, she actually passed from Alzheimers. She ended up getting it when she was in her 90s.

She also found out that she has increased risk for Type 2 diabetes, which she said explained in a sense why she ended up with gestational diabetes when she was pregnant with her daughter, Cairo. Instead of freaking out about what was shared, Tia confidently said that she was glad to have the information.

With that information I now can do whatever I need to do to try to prevent that from happening, she said of the different health issues shes at risk for.At first I was really nervous about receiving this because you just never really know whats going to be revealed, she added. But again, as Ive gotten older, Im really starting to believe that knowledge is power. So the more information I know, even though sometimes that can be scary, you can do something about it.

The whole video was very interesting, because who doesnt love to learn about all things ancestry? Check out her DNA results from her own mouth below:

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Tia Mowry Breaks Down In Tears After Finding Out Results Of DNA Ancestry Test - MadameNoire