Monthly Archives: October 2019

Over 125m people worldwide affected with psoriasis – The News International

Posted: October 27, 2019 at 2:41 pm

Over 125m people worldwide affected with psoriasis

Islamabad:Psoriasis drastically affects the everyday lives of patients as it victimizes more than 125 million people worldwide.

The Pakistan Psoriasis Foundation report states that in an analysis of survey data from 5,000 psoriasis patients, 20% of women said psoriasis was a massive problem in their everyday lives, compared to only 12 % of men. In addition, approximately 60 % of women said psoriasis interferes with their ability to enjoy life, as compared to only 52 per cent of men. Overall, women have greater difficulty dealing with the psychological and social issues brought about by having psoriasis.

Psoriasis is a chronic, inflammatory skin disease clinically evident as raised inflamed scaly red skin lesions that crack and itch. International Psoriasis Day is observed globally on October 29 to increase awareness of one of the most important skin problems. Psoriasis sufferers feel that people in general, including doctors, underestimate the overall impact the disease has on their lives. It is evident that the disease burden of psoriasis extends beyond the physical symptoms experienced by the patient.

Health professional and the general public should not minimize its impact as skin disorders are often chronic but not life threatening but they severely affect the mental well-being of patients. Psychologists who know the impact of the mental anxiety should come forward to help patients, opined Dr. Koukab Gulzar, Consultant Dermatologist at KRL Hospital.

Psoriasis can also cause inflammation of the joints, which is known as psoriatic arthritis. One-third of psoriatic patients have psoriatic arthritis. The risk for diabetes mellitus rises substantially in patients with psoriasis, with a 62% increase in risk noted in patients with severe psoriasis. Psoriasis appears to have a greater impact on womens lives and early cardiovascular deaths have been reported in psoriatic patients. Skin problems are generally the most common diseases seen in primary care settings all over the globe and its prevalence ranges from 20-50% in developing countries.

Psoriasis has a bimodal age of disease onset. The first peak is around 20 and the second peak is around 60. Around one-third of patients are under the age of 18 years. It is said that psoriasis has a genetic basis, as 23.4% to 71% of children will have a family history of psoriasis.

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Health Board: Upcoming conferences, talks, campaigns and events – The Irish Times

Posted: at 2:41 pm

1) As part of Brain Tumour Awareness Week 2019, Brain Tumour Ireland, in partnership with The Royal College of Surgeons in Ireland and Trinity College Dublin, are hosting a public lecture on Finding New Ways in the Lab to Tackle Glioblastoma with Dr Kate Connor PhD, RCSI Dept of Physiology and Medical Physics followed by two GLIOTrain Project PhD students who will give an update on their research and Brain Tumours and Epilepsy: Vital Links Provide Valuable Clues? with Prof Mark Cunningham PhD FTCD, Discipline of Physiology, School of Medicine, Trinity College. The event takes place on Wednesday, October 30th at Trinity Biomedical Sciences Institute, Pearse Street, Dublin 2 from 6.30pm to 8pm. It is a free event, but register your attendance by emailing info@braintumourireland.com or at eventbrite.ie

2) The UCD Centre for Arthritis Research second annual Collaborative Approach to Arthritis Research conference will take place on Friday, November 1st in St Andrews Resource Centre, Dublin 2. The theme this year is Transitions; from before to after diagnosis, from child to adult patient, from work to retirement. Attendance is free but registration is required. See eventbrite.ie

3) Returning for a fourth year to Dundrum Town Centre in Dublin, the Psoriasis Shout Out will see consultant dermatologists, dermatology nurses and patient advocates offer free, one-to-one medical advice and support for people living with psoriasis. With waiting lists to see a dermatologist in Ireland in excess of 18 months, the Shout Out is an opportunity to have an initial chat, get some advice and speak to a dermatologist. The free event takes place on Saturday, November 2nd from 9.30am to 4.30pm on the 3rd floor (beside Tesco) in the centre.

4) As Halloween approaches, people are being warned that novelty contact lenses are dangerous and pose a risk to those who wear them. The warning was issued by CORU, Irelands multi-profession health regulator. Novelty contact lenses may look like harmless fun, but the reality can be far more serious, said Ginny Hanrahan, CEO of CORU. Common problems associated with unsupervised use of contact lenses can include red, sore or dry eyes. Poor quality lenses or poor hygiene practises can also lead to far more serious complications including severe infections that in a worst case scenario could cause permanent blindness. We are strongly advising anyone considering novelty contact lenses as part of a Halloween costume not to wear them.

5) Researchers from the School of Psychology at NUI Galway are currently recruiting participants from ages 16-35 in the Galway area to participate in a new psychology therapy study being trialed for individuals who are in the first five years of a diagnosis of psychosis. Early psychosis, which refers to a range of mental health difficulties often associated with experiences of hallucinations or delusions, can result in significant difficulties with social and occupational functioning. The CReST-R study (Cognitive Remediation and Social Recovery in Early Psychosis Study) focuses on helping to improve everyday functioning in young people living with psychosis. The study will involve weekly one-to-one therapy sessions over the course of 10 weeks, with an assessment before and after completion of therapy. This trial is part of a Health Research Board funded programme entitled YOULEAD (Youth Mental Health Research Leadership) as part of a collaboration between mental health researchers at NUI Galway, UCD and RCSI, and health service providers, including the HSE and Jigsaw. To participate in the study and for more information contact Emma Frawley, crestr@nuigalway.ie, 086 8527199. For more information about YOULEAD, see nuigalway.ie/youlead

6) The Irish Hospice Foundation (IHF) is hosting its annual evening of remembrance on Thursday, November 7th. This is a free public information event allowing people to hear about aspects of loss and bereavement which may help them understand aspects of their own loss. Guest speaker, writer Emma Hayes will talk about Living with Loss following the death of her mother Karen. Emma wrote about her personal experience of grief in The Irish Times. The event takes place at the Alex Hotel, on Dublins Fenian Street from 5.30pm to 8pm. All are welcome to attend.

7) Dublin Rape Crisis Centre (DRCC) will host a one-day conference discussing Sexual Violence in Ireland: Past, Present and Future on Thursday, November 7th (9am-4.30pm) in the Royal College of Surgeons to mark their 40th anniversary. The conference will reflect on the origin and role of the centre. Tickets (10-25) are available via eventbrite.ie

8) Diabetes Ireland is hosting a free Health & Wellbeing Event for people living with, and at risk of, developing diabetes. The event will include exhibitors, workshops, diabetes products, the latest technology and free testing, and takes place at Limerick Strand Hotel from noon-5pm on Sunday, November 10th. Registration is not required.

9) As darkness sweeps around the globe on Wednesday, November 13th, 25,000 people in 50 cities worldwide will put on their running shoes to complete a 5k or 10k Run in the Dark - the principal fundraising event for the Mark Pollock Trust. Run in the Dark will take place in locations across Ireland - from Dingle to Dublin abd Wexford to Galway For more information go to runinthedark.org/ireland

10) A social singing event called Heres a health to the company: Social singing, health and well-being will take place at the Irish World Academy of Music and Dance, University of Limerick on Friday, November 15th. The special event is focused on the health and well-being benefits of social singing, from the perspectives of music therapy, community music, voice studies, traditional song, social justice and more. November 15th is World Music Therapy Day. To register see eventbrite.ie

11) Fighting Blindness Retina 2019 Public Engagement Day takes place during Science Week Ireland on Saturday, November 16th. The event offers people with sight loss an opportunity to quiz leading eye experts about their conditions, and to hear about the latest advances being made to improve and ultimately cure various types of sight loss. The conference will feature research-focussed breakout sessions on more than 20 rare conditions such as retinitis pigmentosa, diabetic retinopathy, age-related macular degeneration, cataracts, glaucoma and many more. Retina 2019 takes place in the Radisson Blu Hotel, Golden Lane, Dublin 8. For information on registration, visit retina.ie

12) The All Ireland Paediatric Diabetes Health Professional Conference 2019 takes place at Carlton Hotel, Dublin Airport from November 28th-29th. For more details, contact info@diabetes.ie, (01) 842 8118.

13) St Patricks Mental Health Services annual Founders Day conference on Friday, December 6th - at St Patricks University Hospital, Dublin 8 will focus on the theme of anxiety. The plenary lecture comes from Prof David Clark of Oxford University, who will be discussing effective psychological treatments for anxiety and the Improving Access to Psychological Therapies (IAPT) Programme. Prof Mark Freeston of Newcastle University will present on the role of intolerance of uncertainty in understanding, formulating and treating anxiety in anxiety disorders and beyond, while Prof Helen Kennerley of the Oxford Cognitive Therapy Centre will explore anxiety and dissociation. For more information and to book a place, visit stpatricks.ie/media-centre/events

For inclusion in these listings, email health@irishtimes.com with Health Board in the subject line

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Clarify Medical Closes $18M Series A Round to Commercialize its Connected Home Phototherapy System in the U.S. – Business Wire

Posted: at 2:41 pm

SAN DIEGO--(BUSINESS WIRE)--Clarify Medical announced today that it has closed an $18M Series A financing round with participation from H.I.G. BioHealth Partners, 7wire Ventures, SV Health Investors, and Bluestem Capital. The proceeds of the round will be used for the commercialization and further development of the Clarify Home Light Therapy System for the treatment and monitoring of patients with chronic skin conditions.

Michael Wasserman, Managing Director of H.I.G. BioHealth Partners; Robert Garber, Partner at 7wire Ventures; and Paul LaViolette, Managing Partner and Chief Operating Officer of SV Health Investors, will join the companys board of directors, effective immediately.

Clarify Medical has attracted a strong syndicate of leading medical technology and digital health investors to fuel its commercialization efforts, said Dr. Wasserman. The significant technological advances of the Clarify System will enable patients with chronic skin diseases like psoriasis, vitiligo, and eczema to safely and effectively manage their conditions at home, while remaining connected to their physicians via Clarifys cloud connectivity. The approach has tremendous benefit for patients, physicians and healthcare providers.

The Clarify System, which has been cleared by the FDA, is indicated for localized phototherapeutic treatment of dermatologic conditions such as psoriasis, vitiligo, atopic dermatitis (eczema), seborrheic dermatitis, and leukoderma on all skin types (I-VI). It is the first and only connected phototherapy system that uses an app on the patients own smartphone (iOS or Android) to manage the dose, frequency, and duration of targeted narrowband UVB (NB-UVB) light therapy; the System helps to ensure that patients receive the proper doses recommended by the American Academy of Dermatology in its published Guidelines of Care for the Management of Psoriasis and Psoriatic Arthritis and The Vitiligo Working Group Recommendations for NarrowBand Ultraviolet B Light Phototherapy Treatment of Vitiligo.

The treatment regimen is prescribed by the patients physician but monitored and controlled by the Clarify System, enabling patients to administer treatment with clinical precision and achieve clinical efficacy in the convenience of their homes. The connected system monitors dosing, adherence, compliance, patient progress, and satisfaction.

There are 30 million people in the U.S. with psoriasis, vitiligo, and eczema and approximately 5,400 medical dermatologists who help these patients treat and manage their conditions.

We are very pleased to have such high-caliber investors join our board, said George Mahaffey, President & CEO of Clarify Medical. In the brief time the Clarify System has been commercially available, weve established Medicare coverage and have helped many patients self-manage their chronic skin conditions at home. With this funding, we are now poised to fully launch the System in the U.S. by improving market access and building awareness within the medical dermatology community that there is now a home phototherapy option that patients can use safely and effectively.

About Clarify Medical, Inc.

Clarify Medical is a private San Diego-based medical device company focused on developing innovative technology, products, and services that improve care for people with chronic skin conditions. Its Clarify Home Light Therapy System is now available nationally in the U.S. Learn more at http://www.clarifymed.com.

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Clarify Medical Closes $18M Series A Round to Commercialize its Connected Home Phototherapy System in the U.S. - Business Wire

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Durect Corporation: DUR-928 Data In Severe Alcoholic Hepatitis To Be Showcased At Upcoming AASLD Meeting – Seeking Alpha

Posted: at 2:41 pm

DURECT Corporation (DRRX) has a drug, DUR-928, that is being studied in alcoholic hepatitis (AH), non-alcoholic steatohepatitis (NASH) and psoriasis. There will be two presentations on DUR-928, including one oral late breaker, at November's AASLD meeting on AH, which is an important cause of liver-related morbidity leading to the need for a liver transplant and has no approved therapy. Current pharmacological therapies include corticosteroids (for which a significant percentage are contraindicated due to infection or acute kidney injury) and pentoxyphylline, but these have not been shown to be very effective. A 2015 study published in the Journal of Clinical Gastroentrology concluded that there are 325,000 alcoholic hepatitis-related hospitalizations in the US annually, with 65,000 representing a primary diagnosis. The study further suggested that, as it relates to the primary AH hospitalization, the cost was $46,000 and the in-hospital mortality rate was 5.8%. The study also noted that the thirty day mortality rate for severe alcoholic hepatitis has historically been in the 30-50% range. Liver transplant is indicated for patients who are steroid failures, but its cost can approach $600,000.

The Phase 2a data on DUR-928, as discussed in the abstracts, showed that the drug was safe at all IV doses. Treatment responders, defined by a Lille score of less than 0.45 were 89%, and among the severe AH patients it was 87%. It was noted that these response rates were significantly better than comparative published historic data. A larger Phase 2b trial is being planned for 2020.

NASH has become a leading cause of liver disease and liver transplant paralleling the obesity epidemic. It is estimated that 10-20 million Americans have the disease, though this could increase given that, according to the OECD, the adult obesity rate in the US is forecast to increase from 38% in 2014 to 47% in 2030. There are currently no approved medications, and it has been shown that a 10% weight loss can reduce the disease severity. The first drug, Ocaliva, should be on the market in mid-2020, but its benefit as monotherapy was seen in only about 23% of patients. I have long maintained that, given the complexity of the disease, pharmacologic treatment is likely to involve a polydrug regimen, and I expect Novo's (NYSE:NVO) oral semaglutide, Rybelsus, to be a cornerstone. DUR-928, in an oral formulation, would be very complimentary, given the beneficial effects it has shown in animal studies on fibrosis and ballooning, and on inflammation, bilirubin and liver injury in a Phase 1 human study. A larger 28 day, Phase 1b study is currrently ongoing, and it will assess safety, pharmacokinetics and some efficacy parameters, while laying the groundwork for a future Phase 2b study. The US NASH market is expected to exceed $10 billion annually, and, in my opinion, the most advanced drugs will represent "first generation" treatments, much like PEG-Intron for Hepatitis C.

DUR-928 is also being studied in a topical formulation for mild to moderate psoriasis. A multi-center Phase 2a trial is slated to have topline data by year end.

Over the next year, DURECT will be advancing DUR-928 in AH, NASH and psoriasis. Data on AH will be provided at November's AASLD, and topline data on NASH and psoriasis will follow soon thereafter. DUR-928 acts via several mechanisms to regulate inflammation, improve cell survival, improve insulin sensitivity, decrease lipid biosynthesis and reduce fibrosis. There is no approved drug for AH, and this market should exceed $1 billion in the US. Although several drugs should be on the market to treat NASH over the next three years, none seem likely to serve the majority of patients as monotherapy. It needs to be understood that NASH progresses from fibrosis stage one to four over a period exceeding a decade, and patients with stage one and two are more likely to die of cardiovascular disease, given the association with hypertension, obesity and Type 2 diabetes. Ultimately, the NASH drug market will be extremely large, with a combination of therapies directed at weight loss, insulin sensitivity and fibrosis required.

As I look at DURECT's stock, I find it similar to other small caps that I have designated as being priced for "non-success". Its lead drug is being advanced in three indications, and it has recently formed a partnership with a leading biopharmaceutical company relating to its legacy drug delivery technology that has brought in $35 million and could bring in additional milestone payments and royalties. Furthermore, the unique characteristics of DUR-928 make it a very attractive candidate for the indications being pursued.

Disclosure: I am/we are long DRRX. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.

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Durect Corporation: DUR-928 Data In Severe Alcoholic Hepatitis To Be Showcased At Upcoming AASLD Meeting - Seeking Alpha

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Report: PGA Tour will have on-site gambling in 2020 – Golfweek

Posted: October 26, 2019 at 1:49 pm

PGA Tour commissioner Jay Monahan, in an exclusive interview with AFP at the Zozo Championship in Japan, said that there will be on-site gambling options for fans in 2020.

Youll start to see product in the market place next year, Monahan told AFP. Its all about engagement. When done right, it gives fans the opportunity to engage with your sport over a longer period of time and have more interest in whats happening across the entire player field.

Noting that sports wagering is legal in many international markets, Monahan says the Tour has put the right systems in place, both in terms of an integrity and monitoring activity.

Specifics werent revealed but Monahan said the Tour will be working with IMG Arena on building out a gambling platform.

Its estimated that by years end, legalization is possible in a dozen states in the Northeast and Midwest but that many states in the South and far West dont seem to be in a big hurry.

Before the May 2018 Supreme Court ruling that allowed sports books across the country, full-service ones were running legally only in Nevada. In 2019, they opened in seven more states. As of this summer, sports books have been legalized but havent yet begun operating in another five, plus the District of Columbia.

Bills are awaiting signatures from the governors in Illinois, Maine and New Hampshire. Colorado voters will decide the matter for that state in November.

USA TODAY contributed to this report.

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Gambling built baseballand then almost destroyed it – Quartz

Posted: at 1:49 pm

Imagine if, after watching the thrilling victory of the Chicago Cubs in Game 7 of the 2016 World Series over the Cleveland Indiansa game in which the Cubs won their first championship in over a centuryyou learned that the Indians had collaborated with gamblers to intentionally throw the series.

Would you trust the game, its umpires, and its players, ever again?

That was the scope of the crisis that enveloped baseball a century ago, when key members of the 1919 Chicago White Sox, including pitchers Eddie Cicotte and Claude Lefty Williams, conspired to throw the series to their opponents, the Cincinnati Reds.

What became known as the Black Sox Scandal rocked professional baseball. But it wasnt an aberration in a sport that was otherwise clean.

Baseball became Americas national pastime because ofand not in spite ofgambling.

In his book Baseball in the Garden of Eden, historian John Thorn explains how gambling was far from an impediment to the games flowering; instead, it was the vital fertilizer.

In baseballs infancy, the sport was thought of as a boys game. But over the course of the 19th century, gambling deepened adult interest and investment in the sport, attracting cohorts of older fans.

Gamblings popularity was helped along by the spread of statistics, that particular lifeblood of baseball that still keeps fans hooked today. Developed initially to allow the results of a game to be printed onto the page in the form of box scores, statistics also created a pool of data that gamblers could use to inform their betsmany of which were made from the stands, in the middle of games.

In his history of Fenway Park, Glenn Stout describes how, in the ballparks early years, the best seats were quickly taken over by a rabid contingent of gamblers who bet on absolute everything imaginable, ranging from the eventual winnerto ball and strike calls and even such arcane issues as whether the wind would change direction. Fans waving dollar bills and barking out bets resembled brokers on the floor of the stock exchange.

This kind of gambling was so common in the stands that Ernest Lawrence Thayers iconic 1888 poem, Casey at the Bat,captured such a moment in one of its stanzas:

A straggling few got up to go in deep despair.

The rest clung to that hope which springs eternal in the human breast;

They thought, If only Casey could but get a whack at that

Wed put up even money now with Casey at the bat.

Some players also sought to get in on the action.

In 1919, the highest-paid player was Detroit Tigers outfielder Ty Cobb, who earned $20,000which equates to roughly $300,000 today, or less than Major League Baseballs current minimum salary.

Most of Cobbs peers earned far less than the future Hall of Famer. Working with gamblers was an attractive way to supplement their incomesand many of them did.

One of the most notorious was first baseman Hal Chase. Dubbed the Black Prince of Baseball by baseball historians Donald Dewey and Nicholas Acocella, Chase made a veritable career out of throwing games. Playing mostly with the New York Highlanders, Chase, as Charles Fountain noted, threw games for money, he threw games for spite, he threw games as a favor for friends, he threw games apparently for no reason at all other than to stay in practice.

But this wasnt the kind of gambling that brought baseball to the brink of disaster in 1919. That scandal saw the players themselvesworking in tandem with professional gamblers and gangstersfix the World Series.

The 1919 World Series was the best-attended Series at that point in the games history, but the play of the White Sox turned the games into elaborate theatrical performances.

Those in on it had to play to lose, and the statistics are telling.

Shortstop Swede Risberg hit .080not a typowhile committing four fielding errors. Outfielder Happy Felsch didnt do much better, hitting .192, with just five hits in 26 at-bats. He also committed two errors. Pitcher Claude Lefty Williams surrendered 12 runs in 16.1 innings of work.

While the players tried to pull off authentic performances for fans, they werent always successful. Felsch was chided by his fellow cheaters for his blunders in center, which they deemed too obvious.

Fundamentally, however, the games lacked the core drama and appeal of sports: the uncertainty of the outcome.

Sportswriters took notice. Rumors were already flying in the press box before the World Series conclusion that something was wrong. Sports journalist Hugh Fullerton had heard these rumors when he arrived to cover the series, though he tried to convince himselfand his readersthat the story couldnt be true. Still, once the series ended, Fullerton wrote worriedly in the Chicago Herald and Examiner that Yesterdays, in all probability, is the last game that will be played in any World Series.

Fullerton kept pursuing the story and became the first sportswriter to break the details to the public in December 1919, with an article in the New York World entitled, Is Big League Baseball Being Run for Gamblers, with Players In on the Deal?

As more details emerged, the scandal overwhelmed the sport and threatened to destroy it. If the World Series itself, baseballs premiere event, could not be trusted, how would the sport survive?

The new baseball commissioner, Kenesaw Mountain Landis, acted decisively and independently of the courts. Even after the players were acquitted in a trial that ended on Aug. 2, 1921, Landisa former federal judgehad already made his decision.

Regardless of the verdict of juries, he announced, on the morning of Aug. 3, 1921, no player that throws a ball game; no player that undertakes or promises to throw a ball game; no player that sits in a conferencewhere the ways and means of throwing games are discussed and does not promptly tell his club about it, will ever play professional baseball.

The stunned White Sox playersincluding stars like Shoeless Joe Jackson, who had hit .375 in the series but was nonetheless aware of what his teammates were up towere banned from baseball for life.

Seventy years later, commissioner Bart Giamatti acted in a similarly swift and punitive manner when he banned all-time hits leader Pete Rose from baseball in 1989.

Bart Giamatti calls the banishment of Pete Rose the sad end to a sorry episode in a 1989 news conference.

Rose had admitted to gambling on his own games, even as a manager. Some thought Giamatti overreacted, given that Rose never bet against his own team.

That argument, as historian Bruce Kuklick wrote in a 1999 essay, doesnt hold up. Rose, he points out, didnt bet on every game. Its not inconceivable, then, that he would make decisions during games in which he didnt place betssay, not bringing in his best relief pitcher to make sure that reliever would be available for the games he did bet on.

Giamatti surely had 1919 on his mind when he meted out Roses punishment. With the game having barely escaped death once, Giamatti knew that organized baseball couldnt risk skating too close to that edge again.

And yet in August of this year, Major League Baseball made FanDuela daily fantasy sports gambling serviceits official gambling partner.

It may be that baseball hopes that gambling will bring more adults back to the sport, just as it did in its early days. After all, attendance at games is down. Football, meanwhile, has become the most watched sport on television in the US. Six million viewers even tuned in for the 2019 NFL Draft.

Gambling may fuel more interest in the sport. But throwing on more fuel can result in a fire that burns out of control. In 1919, baseball came close to burning its own house down. One hundred years later, journalist Hugh Fullerton would surely be stunned to know that big league baseball has once again made a contract with gamblers, in full view of both players and fans.

Lets hope the story doesnt end in scandal this time around.

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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The Legal Gambling Counsel navigates the week 9 slate for the undefeated – Red Cup Rebellion

Posted: at 1:49 pm

The podcast will be back next week, but until then, we have given you our picks in written form for the second week in a row. Dont pay attention to the overall season record, this week seems like a nice time to make some money with some opportunistic lines and over/unders.

Gamble at your own risk obviously, but the LGC is feeling a turn around here.

Cheers. Crack on!

Season record: 43-52 ATS (45.26%)

Im 0-2-1 when backing Virginia this year which means that Im due for a win with the Hoos. Gamblers fallacy, schmamblers fallacy. Louisville is improving, but their wins have come against Eastern Kentucky, Western Kentucky, a bad Boston College team, and Wake Forest without its starting quarterback. Louisvilles defense is one of the worst in the country (100th in SP+), and Im skeptical about their offense being successful against Virginias 14th ranked defense. The Cavs are better at every position and should suffocate Louisville en route to a double digit win.

Betting overs in service academy games is not a wise long term investment strategy, (Im long on Beanie Babies. Theyre going to bounce back any day now.) - but Air Forces offense is 25th in SP+, and in their last 3 Mountain West games, they have scored 56, 43, and 41. Air Forces defense, however, is ranked 83rd, and they are facing a capable quarterback in Utah States Jordan Love. With a QBR of 106 in Mountain West games, Love and the Aggie offense should be able to move the ball efficiently. I expect both teams to get in to the 30s which puts us comfortably over the number.

Tulane no-showed at Memphis as a popular dog last week, but people should have been prepared to have their money taken near Orange Mound (obligatory: TWO FINGERS ROUND, THREE FINGERS DOWN) Navys option offense is typically tough to prepare for in a week, but Fritz is well versed in the triple option, and Tulane played Army earlier this season. Tulanes starting running back could return to the lineup against Navy, and his back up should be a go after leaving the Memphis game early. The Green Wave is too well coached to play poorly in back to back weeks, and I think they win a close one.

I like the Badgers. I will continue to like the Badgers. Ohio State wins but Wisconsin can run on anybody and will shorten this game and cover the line.

Akron is the only team in the country 0-7 against the spread so why not?

Gophers are for real. This also shows some early reverse line movement.

Charlie Strongs true freshman quarterback is injured and may not play. Past him, theres a walk on left in the quarterback room. The wrong team seems to be favored here and I expect a big win for Mike Houston in his first season in FBS.

Too many points for a team that wants to keep possessions to 10 or fewer. A slow, plodding game at 11am in Manhattan means take the points, especially when its practically four scores.

What am I missing here? Tennessee will have a guy at quarterback that either cant throw or they dont trust. Since Brian Maurer went down, the Vols totals are 30 and 48 with the latter coming against Alabama. The Gamecocks are more than content with shortening the game and that horrible Tennessee offense will do nothing but drain the clock.

This one isnt hard. I dont believe in Shea Patterson and Jim Harbaugh to get it done. Point blank. Ian Book can really spin it (completed 64% of his passes for 275 yards against Georgia) and I expect him to carve up the Wolverine secondary. Brian Kelly might be 0-fer in Ann Arbor but I think he gets a W this weekend.

The Cougs have covered nine straight against the Ducks, including winning each of the past four outright. Justin Herbert and the Ducks are for real but this one always seems to be weird. Oregons No. 8-ranked SP+ defense will test Mike Leachs offense but I expect a Pac-12 dogfight in Eugene here.

This is going to feel like a 90s SEC Saturday afternoon game. Auburns only shot is to run wild on LSUs good-but not-great defense and to keep the explosive LSU offense on the bench, but Im not sure thatll happen. But, I do like the idea of Gus Malzahn playing keep away and the Tigers getting theirs when they can.

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Illinois Casino Maps: Riches and ruin of Pritzkers gambling bill – Chicago Sun-Times

Posted: at 1:49 pm

Casino developers are racing to meet a Monday deadline to submit applications to the Illinois Gaming Board to be considered for one of the states six new casino licenses authorized under Gov. J.B. Pritzkers massive gambling expansion.

Illinois 10 existing gambling meccas have chugged a long way from their riverboat origins nearly three decades ago along Illinois waterways, first docking with lawmakers blessing and gradually creeping onto land as the state has increasingly relied on gambling tax revenue.

Casino operators have stretched that riverboat definition as far as the law will bend, with most still considered barges and a few built over shallow pits of water to meet state requirements.

Eager developers are now painting rosy images of vast new entertainment complexes ones that are now allowed to break ground on land without any aquatic pretenses costing hundreds of millions of dollars in this latest gaming growth, which Pritzker is banking on to help fund his signature $45 billion capital plan for statewide construction projects.

Thats despite the fact casino admissions and revenues have steadily declined in Illinois over the last decade. And anti-gambling activists are preparing for what they say will lead to a surge in addiction.

Take a spin through our map to survey the states current gambling scene and where its expected to grow. Youll also find out which Illinois casino inspired a Wilco song, where one particularly corrupt suburban politician liked to play the slots, how the states first casino ended up in last place and which entertainer wants you to want to go to a casino envisioned for Rockford.

The new law allows for casinos in five specific municipalities Chicago, Waukegan, Rockford, Danville in eastern Illinois and Downstate Williamson County plus another casino pegged for a broader area of southern Cook County. Casino developers need approval from the local government to apply to the Gaming Board.

While officials in Danville, Rockford, and Williamson County have all advanced single-site proposals from handpicked developers, Waukegan has approved three competing bids all earmarked for the same site and will leave it up to the Gaming Board to decide. And six different bidders are duking it out with competing sites for the south suburban Cook County casino license.

Amidst all that forward movement, the fate of the Chicago casino is up in the air as Mayor Lori Lightfoot goes back to the drawing board with Springfield lawmakers to try to salvage a viable plan. A state-hired consultant deemed taxes too onerous for any developer to make a decent profit under the version the Legislature passed in June. The consultant also shot down the five South and West side city sites Lightfoot floated, arguing a downtown location would be more lucrative.

The gambling legislation signed over the summer could eventually more than double the number of places Illinoisans will be able to place a bet. Among other new gambling forays, including yet-to-be-launched legal sports betting, it also allows the states horse racetracks to become racinos with slot machines and table games, and it increases the number of allowable gaming positions for the states 10 existing casinos from 1,200 to 2,000.

The Gaming Board has up to a year to navigate through the casino applications.

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Online gambling and property prices in ASEAN – The ASEAN Post

Posted: at 1:49 pm

Will the end of Chinese involvement in ASEANs online gambling sector see a spiral in property prices?

A stark example of this is playing out in Cambodia, where there have been reports of the property bubble bursting in Sihanoukville a beach town now known for its casinos after Prime Minister Hun Sen announced that the country would stop issuing online gambling permits on 18 August.

In the Philippines, though, President Rodrigo Duterte has remained steadfast in his support for online gambling, and the revenue it earns for the countrys coffers, despite increasingly stern warnings from Beijing.

Gambling is illegal in China and online gambling centreswhich cater to Chinese nationals have sprouted up across ASEAN as a result most notably in Cambodia and the Philippines.

Gambling syndicates hire Chinese to operate these online gambling centres, and the influx of Chinese nationals employed in the online gambling sector in both Cambodia and the Philippines is well documented.

While this has driven up rental prices both for office space which host these centres and premises which house the workers this may soon be a thing of the past.

Cambodia

Bradley Murg, director of Global Development Studies at Seattle Pacific University, told Casino.org that his sources in Sihanoukville estimate that around 10,000 Chinese had left the city by the first week of September as a result of Hun Sens directive.

Those that depart will likely go to China first, with many making their way to the Philippines in light of Manilas decision to keep online gambling open, despite Chinese pressure to close the sector down, Murg told the industry website.

Speaking at a real estate expo earlier this month, Kim Heang, CEO of Khmer Real Estate, told Cambodian media that such departures will take a toll on the property sector in Sihanoukville, Poipet and Bavet.

The buildings in Sihanoukville that used to be rented out for US$20,000 a month, no one is renting them now, not even for US$8,000 a month, he said.

James Hodge, the director of international real estate firm CBRE Cambodia, told Cambodian media that there has been a reduction in land prices in Sihanoukville a backpackers haven which has now been transformed into the Macau of Southeast Asia thanks to Chinese investment and gamblers.

Philippines

While the Filipino government estimates that there are some 130,000 Chinese nationals working for over 50 online gambling companies in the Philippines, insiders say the number is closer to 300,000.

The influx of Chinese workers has driven up property prices, and there are stories of Filipinos moving out of their homes and renting them to Chinese online gambling operators as they stand to make nearly three times the going rate in rent.

They (Chinese online gambling companies) came in and saved the office market, Dom Fredrick Andaya, a director at real estate firm Colliers International Philippines told international media in July. We would have had double-digit vacancy rates by 2017 if they did not come.

Another firm, Leechiu Property Consultants, said in March that strong demand for property by online gambling operators has seen rent in certain areas of Manila spike by as much as 80 percent over the last three years.

Is this sustainable though?

Boo Chanco, a business columnist at the Philippine Star, certainly does not think so writing in June that a crackdown on online gambling will lead to the property market cooling down so fast our stock market may experience an ice age.

Noting that private construction of office buildings and condominiums might slump as well, Chanco stressed that the amount of business and residential floor space turning vacant would bring down rental costs in the capital, especially in popular areas such as the Bay Area, Makati, BGC and Ortigas.

Malaysia

According to international research house ECA International in March, the average rental price for an unfurnished, three-bedroom apartment in the mid-range of the expatriate market in Kuala Lumpur was RM6,632 (US$1,621) per month.

Chinese online gambling syndicates, though, are paying well above market value in Malaysia where online gambling is illegal.

While there are no substantive reports linking Chinese online gambling activities to a rise in real estate prices in Malaysia, a police raid at a 20-bedroom luxury bungalow which netted 117 Chinese nationals revealed that the syndicate rented the mansion for RM30,000 (US$7,200) a month presumably a bargain considering they were raking in RM500,000 (US$120,000) a day.

While it may be difficult to predict the effects of Chinese online gambling on property prices across the region, one thing for sure is that increased pressure by China or another sudden ban such as Hun Sens in August will inevitably lead to the sector collapsing leaving landlords and property developers who depend on them high and dry.

Related articles:

Is China using ASEAN for its gambling fix?

How China changed Sihanoukville

Singapore property prices predicted to increase by 10%

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Online gambling and property prices in ASEAN - The ASEAN Post

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Five Reasons US Online Gambling Will Be Dominated By A Few Brands – OnlinePokerReport.com

Posted: at 1:49 pm

The US online gambling market is still in its infancy, in the process of figuring itself out. So, how many different brands will gamblers have to choose from when the industry settles into its stride?

New Jersey and Nevada have had online gambling for a few years now, giving us an idea of how things might play out elsewhere.

We can also look to the United Kingdom for what to expect. The US online gambling market is expected to be similar in size to the UK within a matter of years. Sports betting is also expected to make up a large portion of US online gambling activity, as it does across the Atlantic.

There are already 22 online casinos in New Jersey, 15 online sportsbooks and four online poker rooms. In the UK, the top 10 brands control about an 80% market share between them.

Looking at those numbers on their own, it seems reasonable to expect a lot of competition in the US market as it expands. However, New Jersey and Nevada are special cases due to their long history of brick-and-mortar gambling. The UK is also very different from the US economically, culturally and from a regulatory perspective.

When the dust begins to settle in the US, its quite likely that the market will be dominated by a relatively small number of brands. Heres why.

The recent string of corporate tie-ups is the biggest sign that competition could be limited. The market hasnt even gotten off the ground yet. Some potential competitors are acquiring or merging with one another.

The biggest and most recent of these is the acquisition of The Stars Group (TSG) by Flutter. If that goes through as planned next year, it will create the worlds largest gaming company by a good margin. TSG also acquired an elite UK brand in Sky Betting & Gaming last year.

Flutter, for its part, was created by a merger between Paddy Power and Betfair. It went on to acquire FanDuel following the fall of the federal sports betting ban in the US in 2018.

This is far from the only example. Another is the GVC acquisition of the bookmakers Ladbrokes and Coral in 2018. These two brands had already merged in 2015.

It would not be surprising to see further consolidation of brands into large conglomerates in the coming years. In fact, it would be somewhat surprising if we didnt.

Where the brands are already established, like the UK, they continue to operate semi-independently. In new markets like the US, however, theres little reason to operate multiple brands under the same vertical. Flutter will likely concentrate on PokerStars, Fox Bet and FanDuel, and GVC on Roar Digital and the Party brand.

It isnt only big deals between gambling companies that we see, either. Operators are scrambling to get smaller deals in place with both media outlets and various sports leagues and teams. Some of these agreements are exclusive.

Just looking at a few of the deals in place for TSG/Flutter, we have:

Other major gaming companies have likewise been working on various sports and media partnerships. These are going to be key to marketing in the US.

Latecomers to market will have a hard time finding such partnerships and may not be able to compete without them.

The amount of money American companies spend on advertising also acts as a barrier to entry for some operators.

Total gambling ad spent in the US this year is projected to be around $735 per capita, compared to around $485 in the UK. Thats more than a 50% difference.

A young marketmeans that companies big and small will be advertising more intensely than they would in an established one.

In 2015, as the US daily fantasy sports market gained traction, FanDuel and DraftKings spent over $200 million on advertising between them. As the US online gambling market opens up, expect a flood of advertising dollars from the likes of Flutter/TSG, GVC, Caesars and so on.

That creates a huge disincentive to smaller international brands eyeing the market, let alone anyone trying to establish a new brand. The cost just to get noticed amidst the noise will be astronomical at first and likely stay that way for several years.

Part of the reason that brands proliferate in Europe is that it consists of a large number of similarly-sized countries. Many of these end up producing their own national brands. And when those national brands reach a certain size, they sometimes spread out into adjacent markets.

Paddy Power was an Irish brand that spread to the UK before merging with Betfair. Swedish company Betsson has similarly become a force in the UK and throughout Europe. And so on.

North America is just starting to see some cross-border brand expansion from Canada to the US.

The sports app theScore, which now has a betting product, is the lone example, so far. With sports betting legal in only a fraction of US states, the size of the Canadian and American markets is similar at the moment.

Once more states legalize betting, though, the US market will be much larger than Canada. Cross-border branding will flow mostly the other way at that point. Its unlikely that the US public will ever have much interest in Mexican brands, either.

In the long-run, the key brands in the US will be either homegrown or owned by major international companies.

There could, in fact, be many brands in the US market eventually. If thats the case, though, many will not be national brands.

The nature of the US market is that its divided because online gambling is being legalized on a state-by-state basis. Each has its regulatory requirements and an individual licensing fee.

Geographic expansion in the US, therefore, comes not only with a marketing cost, but licensing and development costs as well.

The major brands like PokerStars/Fox Bet, Roar Digital, Caesars, etc. will launch wherever they can. Smaller brands, however, might choose to focus on just one or two states in order to keep those costs down.

Furthermore, some states will not allow private companies to operate at all. Some are granting their state lotteries a monopoly, which will keep those brands local. See, for example, Sportsbook Rhode Island.

Other states require online operators to have a land-based partner, such as a casino. Big companies like GVC and The Stars Group have shown a preference for selecting smaller partners, which wont interfere with their branding.

However, popular casinos such as Parx in Pennsylvania are seeking out white label partners to provide their online gaming platforms. Parx has already expanded into neighboring New Jersey because it is almost as well-known there as it is in Pennsylvania.

Its dubious whether the Parx Online brand would fare well elsewhere, however, where the casino doesnt enjoy the same name recognition.

The most likely way things will play out, then, is that there will be in the vicinity of eight major national brands, but the same few companies will own many of these:

Depending on how things go, some other international operators like 888 and Kindred Group may manage to establish a national presence in the US. Kindred is already trying with its Unibet brand in New Jersey.

Beyond that, there will likely be a large number of local brands based on state lotteries, land-based casinos and racetracks. These are unlikely to hold much market share at the national level.

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Five Reasons US Online Gambling Will Be Dominated By A Few Brands - OnlinePokerReport.com

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