15 facts about fecal transplants The straight poop – Genetic Literacy Project

I was a little surprised to see Ethical Issues in Fecal Microbiota Transplantation festooning the cover of the May issue of The American Journal of Bioethics not their typical topics of gene editing and testing, stem cells, and medical matters of life or death. But as fecal transplants become more medically accepted, questions of access and quality control are indeed arising. So here are a few scintillating facts about borrowing bowel microbiomes to combat dysbiosis.

1. The only sort-of approved use of FMT is for recurrent infection with Clostridium difficile, which causes severe diarrhea. The infection is usually acquired in a health care facility. A 2013 FDA enforcement discretionruling allows doctors to provide FMT without filing an Investigational New Drug Application but only to treat C. diff infection (CDI). Its 90% effective! The procedure is in clinical trials for other indications, albeit against a backdrop of widespread DIYvariations on the theme.

2. The procedure may become frontline treatment for CDI, not just a last resort when antibiotics have failed to control the terrifying torrents of watery stool. And its needed. Results of a study reported in the Annals of Internal Medicine found that cases of multiply recurrent CDI more than two bouts in a short time period are increasing at more than four times the rate of the infection in general. The numbers are daunting: up to half of the 500,000 people in the US who get CDI annually get it again at least once, for a total cost exceeding $5 billion a year. Drug resistant strains are arising and new drugs are coming on the market, but a fecal transplant may be the way to go from the get-go. CDI, say many whove had it, is far worse than overcoming the ick factor of receiving a bit of foreign poop.

3. Some medical organizations and insurers (including Medicare) cover fecal transplants for CDI.

4. Whats in a bowel movement? From 25 percent to54 percentof the solid portion after removing the 75 percent thats water consists of bacteria. The rest is undigested nutrients, electrolytes, and mucus, with color from bile pigments and odor from bacterial compounds (phenols, indole, skatole, ammonia, and hydrogen sulfide). But stool composition varies daily in individuals, which will complicate standardizing transplants. It also presents an obstacle to using a microbiome profile as a form of identification. One bioethicist mentioned checking stool at airports to see whether travelers have come from countries banned from immigration. Would a passport from a Swede be accepted if her feces harbor bacteria native to Somalia?

5. Fecal transplants may conjure mental images of turkey basters, but the material is delivered via enema, colonoscope, nasogastric tube (a nose hose), or capsule.

6. The technology is at least 1,700 years old. The first recorded use was in4th century China by a physician, Ge Hong, to treat food poisoning and diarrhea. In various times and places, poop has been delivered as yellow soup to humans and other animals (especially cattle) and German soldiers reportedly infused camel feces to treat bacterial diarrhea during World War I.

7. Reductionists attempting to drill down to the good stuff in a turd and then recreate it note that just part of a microbiome need be transferred, akin to a keystone organism in an ecosystem. Seres Therapeutics SER-109a capsule that delivers an ecology of bacterial spores enriched and purified from healthy, screened human donors is in phase 3 clinical trials to treat CDI. More mysterious is SER-262 the first synthetically-derived and designed microbiome therapeutic. It fared well against placebo in a 24-week phase 1 randomized controlled clinical trial.

8. Researchers are hard at work describing the optimal feces donor. Most references cite the Amsterdam protocolin this regard. And the American Gastroenterological Association maintains a National FMT Registrytomonitor adverse events and the details of donors. Will we one day have poop centers much like frozen yogurt shops where a hopeful recipient can order up a particular fecal microbiome? Or even mix flavors?

9. Altering the intestinal microbiome might treat autism, Parkinsons disease, depression, and anxiety, perhaps by affecting serotonin levels, thanks to the gut-brain axis.In an intriguing experiment, stool from people with major depressive disorder had a different effect on depression-like behaviors when transplanted into germ-free mice compared to the rodents more spirited response to stool from happy humans.

10. Should people pay for poop, like they do for sperm? Should we patent exceptionally healing donations? Anyone remember The Repository for Germinal Choice, an ill-fated California sperm bank for Nobel-prizewinners?

11. Delivery. Once feces donations are standardized, how will they be prepared and shipped? Dried out like sea monkeys? Fedex? UPS? Amazon Prime?

12. Should informed consent for a recipient include knowing the donors diet? Would a transplant from a person who ate pork be like implanting pig heart valves into an orthodox Jewish person? Might a recipient request a vegan donor?

13. OpenBiomeis a nonprofit stool bank that sends frozen matter to hospitals. Founded by a relative of someone who fought CDI futilely with seven rounds of vancomycin before a transplant helped, the company pays $40 for donating several times a week for two months. Stool must pass two rounds of screening, and the original owner must be aged 18-50, have a BMI under 30, and live nearCambridge, MA, where donations are deposited. The homepage opens to an image of clean, white bottles countering the ick factor is a big challenge for this emerging industry.

14. Fecal transplantation may have unexpected effects, especially since standardizing it as a medical substance is so challenging. The first noted was obesity, which is sort of obvious, but one man who had alopecia since age 6 had a transplant to treat CDI and grew so much hair that he had to shave!

15. AdvancingBiotreats private payers. Prep costs $115 and delivery depends on the route: esophagogastroduodenoscopy (down the hatch) is $307 and colonoscopy $341 to $591. The become a donor page shows 10 smiling people, most of them millennials. Those willing to sell their excrement must be between the ages of 18 and 65, have a BMI under 35, provide a medical history, and have a blood test for infections, including cholera, E. coli, plague, foodborne Salmonella and Shigella, as well as various eggs and larvae. Presumably the donation must score a healthy type 3 or 4 on the Bristol Stool Chart.

Stay tuned. Scatological jokes aside, fecal transplantation is a valid medical procedure that will likely continue to find new niches.

Ricki Lewis has a PhD in genetics and is a genetics counselor, science writer and author of Human Genetics: The Basics. Follow her at her website or Twitter @rickilewis.

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15 facts about fecal transplants The straight poop - Genetic Literacy Project